Thesis (Ph. D.)--University of Pennsylvania, 1931. / Includes bibliographical references.

Thesis (Ph. D.)--University of Pennsylvania, 1931. / Includes bibliographical references.

Discerner les différentes composantes de la religion permettra de saisir la portée de l'analyse que mène Haddâd. Quelle dimension porte sa conception de l'Islam ? Père Youssef Dûrra El-Haddad, surnommé le Maître (al-Ustâdh) est né en 1913 à Yabrûd Kalamûn en Syrie. Au Liban, il s'est consacré à la recherche et à l'écriture. Maître Haddad publiera des articles et écrira des livres jusqu'après sa mort en 1979. Sa consécration aux études coraniques et au rapport islamo-chrétien attire sur lui l'attention depuis les années de formation à Jérusalem, et devient à la base d'une œuvre enrichissante en langue arabe. Maître Haddad réfléchit sur l'Islam selon deux axes : 1. d'abord il cherche une nouvelle "définition" de l'Islam autrement dit il l'aborde d'une façon nouvelle et avec de nouveaux critères. 2. En deuxième lieu il pose l'assise d'une nouvelle stratégie du dialogue islamo-chrétien afin de proposer un credo commun. Le point culminant, de sa recherche est: Comment dialoguer entre musulmans et chrétiens et professer un credo unique ? Comment dire le rapprochement et en quels termes ? Comment considérer le dialogue et sur quelle base ? Pour Haddad, la référence commune et le critère ultime sont textuels. Confrontons donc les deux sources d'Ecrits avant d'aborder les points conflictuels. Mais Comment va-t-il faire pour atteindre ce but ? Comment atteindre la foi musulmane primitive ? Selon Maître Haddad, Les textes interrogés peuvent révéler le point de départ d'un dialogue voire d'un rapprochement entre les deux expressions de la foi. Il est donc bénéfique de se rencontrer sur un terrain d'entente. Haddad interroge donc l'ultime référence, le Coran, afin de mettre en relief l'importance de la Bible, Torah et Evangile, selon les écrits musulmans. Comment ramener l’Islam et le mettre avant le christianisme alors qu’il est historiquement après lui ? Ainsi, l'Islam pourrait-il être reconduit à découvrir ses sources chrétiennes. Ce déplacement des bases du dialogue est un des fondements sur lesquels s'appuie l'œuvre de Haddâd. La question qui se pose est la suivante: Comment situer sa théologie de l'Islam et comment classer sa vision ? Comment considère-t-il l'Islam, et qu'est ce qui différencie sa vision des autres approches de cette religion ? Cette étude analyse sa vision sur l’Islam et sur le dialogue islamo-chrétien telle qu’elle est présentée dans son œuvre. / By distinguishing the different components of Religion, one may be able to better understand the meaning behind Haddad’s analysis. Which dimension does the islamic conception take? Father Haddad, nicknamed the Master, was born in 1913 in Yabrud Kalamun, Syria. In Lebanon, he devoted his life to research and writing. He continued publishing articles and writing books until his death in 1979. His consecration to the Qur'anic studies and the christian-muslim relation attracted his attention since the years of training in Jerusalem; and it becomes at the base of a work rewarding in Arabic language. Master Haddad thinks of Islam from two perspectives: First, he sought a new 'definition' of Islam—addressed in a new way and with new criteria. Secondly, he laid the foundation of a new strategy of the Christian-Muslim dialogue in order to propose a common creed. The essential point of his research: how do we communicate between Muslims and Christians and profess a single creed? How do we define the approximation and in what terms? How do we consider the dialogue and on what basis? According to Haddad, the common reference and the ultimate criterion are textual. Therefore, let’s confront the two written sources before addressing the conflicting points. But how is he going to achieve this goal? How is he going to reach the primitive Muslim faith? According to Master Haddad, the texts surveyed can reveal the starting point of a dialogue or even of a rapprochement between the two expressions of faith. It is therefore beneficial to meet on common ground. Haddad interrogated the ultimate reference, the Qur'an, in order to highlight the importance of the Bible, Torah and Gospel, according to the Muslim writings. How do we bring the Islam and place it before the Christianity when it is historically after it? Thus, could Islam be extended to discover its Christian sources? This movement of the databases of the dialogue is one of the foundations on which Haddâd based his work. The question arises: How does he specify his theology of Islam and how does he classify his vision? How does he consider Islam, and what differentiates his vision from other approaches to this religion? This study analyzes its vision on Islam and on the christian-muslim dialogue as it is presented in his work.

Made available in DSpace on 2014-07-29T15:07:54Z (GMT). No. of bitstreams: 1 dissertacao Filipe ciencia Animal - Clinica e Cirurgia Animal.pdf: 1546193 bytes, checksum: 01b61544014ff3cebd3f43ddb04b8408 (MD5) Previous issue date: 2009-01-30 / The adhesions formation after surgical procedures in the spine is a subject well studied in neurosurgery, according to the discomfort and postoperative pain suffered by patients. Several studies have been performed using anti-inflammatories, autologous grafts, xenografts and xenologer biomaterials and even in film form and gel with the aim of reducing or preventing adhesion formation. The aim of this study was to compare the film based on chitosan with autogenous fat in preventing dural adhesions in rabbits. This technique was compared to the technique used routinely by neurosurgeons who, in most cases, using autogenous fat. We used 24 adult male rabbits of New Zealand, and 15 and 30 days postoperatively (PO) the spinal cords of animals underwent myelography and histological evaluation. The animals were randomly divided equally into two groups (group G and Q), and further subdivided into four subgroups: G15, Q15, G30 and Q30 according to time points and the material used. In the group Q, a laminectomy performed between L1-L2 was occluded with the film based on chitosan and in the Group G the defect was repaired with autogenous free fat graft. In assessing myelography, there was a moderate compression of the column spinal cord both in group G as in group Q. In two rabbits of group Q the compression was attributed to severe disruption of the stabilization made with surgical steel wire. There was no significant difference (p ≤ 0.05) between groups and subgroups. After the pre-established postoperatively, fibrous adhesion from mild to intense between the dura and the implant was noted in animals from both groups, with fibrosis and collagen fibers interspread with the tissue and implant withought, no statistically significant difference (p ≤ 0.05) between groups and subgroups. There were cell infiltrates and giant cells that were more intense in the group Q. At 15 and 30 days postoperatively, the films based on chitosan were coated by inflammatory cells with areas of central necrosis. At 30 days postoperatively, the material had a fibrous capsule surrounding the inflammatory focus and the implant was noticed statistically significant (p ≤ 0.05) of 5% when comparing the groups and subgroups. Based on the results we can conclude that the film based on chitosan, as well as a free autogenous fat reduces the extent of dural adhesions in rabbits, however, the film based on chitosan as well as any foreign body, induces crhonic and intenses inflammatory responses in the rabbit / A formação de aderências após procedimentos cirúrgicos na coluna vertebral é um tema bastante estudado na neurocirurgia, em função do desconforto e dores pós-operatórias sofridas pelos pacientes operados. Diversos estudos já foram realizados utilizando antiinflamatórios, enxertos autólogos, heterólogos e xenólogos e ainda biomateriais na forma de filme e gel com a finalidade de reduzir ou prevenir a formação de aderências. O objetivo deste estudo foi comparar o filme à base de quitosana com a gordura autógena na prevenção de aderências durais em coelhos. Tal técnica foi comparada à técnica realizada rotineiramente pelos neurocirurgiões que, na maioria dos casos, utilizam a gordura autógena. Foram utilizados 24 coelhos da raça Nova Zelândia, machos, adultos, e após 15 e 30 dias de pós-operatório (PO) as medulas espinhais dos animais foram submetidas à avaliação mielográfica e histológica. Os animais foram distribuídos aleatoriamente em dois grupos (grupo G e grupo Q) de igual número, sendo posteriormente subdivididos nos subgrupos G15,Q15, G30 e Q30 de acordo com os momentos de avaliação e o material utilizado. Nos animais do grupo Q, a laminectomia realizada entre L1-L2 foi ocluida com o filme à base de quitosana e no grupo G o defeito foi reparado com enxerto de gordura autógena livre. Na avaliação mielográfica, foi observada compressão moderada na coluna dorsal da medula espinhal tanto nos animais do grupo G quanto nos animais do grupo Q. Em dois coelhos do grupo Q ocorreu compressão grave atribuída à ruptura da estabilização feita com fio de aço cirúrgico. Não foi observada diferença significativa (p≤0,05) entre os grupos e subgrupos. Decorridos os períodos pré-estabelecidos de PO, foi notado nos animais de ambos os grupos, aderência fibrosa de leve a intensa entre a dura-máter e o implante, com fibrose e fibras colágenas entremeadas ao tecido conjuntivo e implante, sem diferença estatística significativa (p≤0,05) entre os grupos e subgrupos. Verificou-se infiltrados celulares e células gigantes, sendo este achado mais intenso nos animais do grupo Q. Aos 15 e 30 dias de PO, os filmes à base de quitosana encontravam-se revestidos por células inflamatórias com áreas de necrose central. Aos 30 dias de PO, o material apresentava cápsula fibrosa circundando o foco inflamatório e o implante, tendo sido notada diferença estatística significância (p≤0,05) de 5%, quando comparados os grupos e os subgrupos entre si. Com base nos resultados pode-se concluir que o filme à base de quitosana, assim como a gordura autógena livre reduz a extensão das aderências durais em coelhos, porém, o filme à base de quitosana assim como todo corpo estranho, induz respostas inflamatórias tissulares crônicas e intensas no coelho

Tesis por compendio / [ES] La criopreservación de semen de peces es una técnica que puede aumentar la eficiencia de la reproducción en cautiverio de especies de peces de agua dulce y marinas. A lo largo de las últimas décadas, se han establecido protocolos para criopreservación de semen de diversas especies de peces. Sin embargo, el foco principal de los pescadores ha sido en tener éxito en el congelamiento y descongelamiento de los espermatozoides, no llevando en cuenta el período en que los gametos se quedan expuestos a la solución crioprotectora en un momento previo a la fertilización. Esta exposición de los espermatozoides a las soluciones crioprotectoras después del descongelamiento puede ser perjudicial a la calidad de los gametos, ya que pueden ser tóxicos. La mayoría de los protocolos establecidos utilizan recipientes de plástico ultrarresistentes para almacenar el semen durante el proceso de criopreservación. Estos recipientes normalmente no se reutilizan, generando residuos altamente contaminantes al medio ambiente. Así, el objetivo principal de la tesis fue crear y probar métodos de bajo costo que potencialicen el uso de los espermatozoides descongelados de peces y torne el proceso de criopreservación de semen menos contaminante al medio ambiente. Los experimentos de los capítulos 1 y 2 se llevaron a cabo en Brasil. Utilizamos el jundiá gris Rhamdia quelen, especie considerada modelo experimental para peces nativos de América del Sur. En el capítulo 1, probamos el uso de la dilución de semen descongelado para disminuir la toxicidad de la solución crioprotectora. La técnica se utiliza comúnmente en protocolos de criopreservación de semen de mamíferos, pero nunca antes se había aplicado al semen descongelado de peces suramericanos. Muestras de semen descongelado de R. quelen se diluyeron en un diluyente salino (NaCl al 1,1% - 325 mOsm kg-1; pH 7,6). Después, observamos que los espermatozoides de muestras diluidas mostraron mayores velocidades, rectitud, progresión y frecuencia de batido flagelar que las muestras no diluidas. La dilución del semen descongelado también proporcionó mayores tasas de fertilización y eclosión que el grupo no diluido. De esta manera, la dilución de semen descongelado de R. quelen resultó ser una metodología sencilla, económica y eficiente que debe incluirse en el protocolo de criopreservación del semen de la especie. En los capítulos 2 y 3 desarrollamos y probamos la metodología para el uso de cápsulas de gelatina biodegradables (colágeno) y cápsulas de hipromelosa biodegradables (HPMC) como recipiente alternativo al uso de pajuelas de plástico en la criopreservación de semen de peces. En el segundo capítulo observamos que las cápsulas biodegradables mantuvieron los parámetros cinéticos y la capacidad reproductiva del esperma de R. quelen así como las pajuelas de plástico.Los procedimientos experimentales del capítulo 3 se llevaron a cabo en España. En este capítulo aplicamos la metodología desarrollada en el capítulo 2 para la criopreservación del semen de anguila europea Anguilla anguilla, dorada Sparus aurata y lubina Dicentrarchus labrax. En estas tres especies, las cápsulas biodegradables conservaron los parámetros cinéticos y la integridad de la membrana de los espermatozoides, así como las pajuelas de plástico. Además, observamos que el daño al ADN en muestras de semen de anguila europea y lubina europea criopreservadas en cápsulas y pajuelas no difirió. Sin embargo, las muestras de semen de dorada mostraron mayor daño en el ADN que las criopreservadas en pajuelas. Aunque, el nivel de daño que observamos en las muestras almacenadas en las cápsulas se considera bajo, por lo que pueden no comprometer el desarrollo embrionario. Evaluamos los resultados y concluimos que las cápsulas de gelatina biodegradables y las cápsulas de HPMC biodegradables pueden utilizarse como recipientes alternativos al uso de pajuelas de plástico para la criopreservación de semen de las cuatro especies de peces. / [CA] La criopreservació de l'esperma de peixos és una tècnica que pot augmentar l'eficiència de la reproducció en captivitat d'espècies de peixos d'aigua dolça i marins. Al llarg de les dècades passades, s'han establert protocols per a la criopreservació de l'esperma de diverses espècies de peixos. No obstant això, el focus principal dels pescadors ha estat tenir èxit en la congelació i descongelació dels espermatozoides, sense tenir en compte el temps en què els gamets queden exposats a la solució crioprotectora abans de la fecundació. Aquesta exposició dels espermatozoides a les solucions crioprotectores després de la descongelació pot ser perjudicial per a la qualitat dels gàmetes, ja que poden ser tòxics. La majoria dels protocols establerts utilitzen recipients de plàstic ultrarresistents per emmagatzemar l'esperma durant el procés de criopreservació. Aquests recipients normalment no es reutilitzen, generant residus altament contaminants per al medi ambient. Així, l'objectiu principal de la tesi va ser criar i provar mètodes de baix cost que potenciïn l'ús dels espermatozoides descongelats de peixos i facin que el procés de criopreservació de l'esperma sigui menys contaminant per al medi ambient. Els experiments dels capítols 1 i 2 es van dur a terme a Brasil. Vam utilitzar el jundia gris Rhamdia quelen, una espècie considerada com a model experimental per a peixos natius d'Amèrica del Sud. En el capítol 1, vam provar l'ús de la dilució de l'esperma descongelat per reduir la toxicitat de la solució crioprotectora. Aquesta tècnica s'utilitza comúment en protocols de criopreservació de l'esperma de mamífers, però mai abans s'havia aplicat a l'esperma descongelat de peixos sud-americans. Mostres d'esperma descongelat de R. quelen es van diluir en un diluent salí (NaCl al 1,1% - 325 mOsm kg-1; pH 7,6). Després, vam observar que els espermatozoides de mostres diluïdes mostraven majors velocitats, rectitud, progressió i freqüència de batuda flagel·lar que les mostres no diluïdes. La dilució de l'esperma descongelat també va proporcionar majors taxes de fecundació i eclosió que el grup no diluït. D'aquesta manera, la dilució de l'esperma descongelat de R. quelen va resultar ser una metodologia senzilla, econòmica i eficient que ha d'incloure's en el protocol de criopreservació de l'esperma de l'espècie. En els capítols 2 i 3 vam desenvolupar i provar la metodologia per a l'ús de càpsules de gelatina biodegradables (col·lagen) i càpsules d'hipromelosa biodegradables (HPMC) com a recipient alternatiu a l'ús de canuts de plàstic en la criopreservació de l'esperma de peixos. En el segon capítol vam observar que les càpsules biodegradables mantenien els paràmetres cinètics i la capacitat reproductiva de l'esperma de R. quelen així com els canuts de plàstic. Els procediments experimentals del capítol 3 es van dur a terme a Espanya. En aquest capítol vam aplicar la metodologia desenvolupada al capítol 2 per a la criopreservació de l'esperma d'anguila europea Anguilla anguilla, daurada Sparus aurata i llobarro Dicentrarchus labrax. En aquestes tres espècies, les càpsules biodegradables van conservar els paràmetres cinètics i la integritat de la membrana dels espermatozoides, així com els canuts de plàstic. A més, vam observar que el dany a l'ADN en mostres d'esperma d'anguila europea i llobarro europeu criopreservades en càpsules i canuts no es va diferir. No obstant això, les mostres d'esperma de daurada van mostrar més dany a l'ADN que les criopreservades en canuts. Tot i això, el nivell de dany que vam observar a les mostres emmagatzemades en càpsules es considera baix, pel que poden no comprometre el desenvolupament embrionari. Vam avaluar els resultats i vam concloure que les càpsules de gelatina biodegradables i les càpsules d'HPMC biodegradables es poden utilitzar com a recipients alternatius a l'ús de canuts de plàstic per a la criopreservació de l'esperma de les quatre espècies de peixos. / [EN] Fish sperm cryopreservation is a technique that can increase the reproduction in captive efficiency of freshwater and marine fishes.Over the last few decades, protocols for sperm cryopreservation from many fishes have been established. However, the researchers' main focus was successfully freezing and thawing sperm, neglecting the period in which the gametes remain in contact with the cryoprotective solution until fertilization. Exposure of sperm to cryoprotectant solutions after thawing can be harmful to the quality of the gametes since they can be toxic. The majority of the established protocols use ultra-resistant plastic containers to store sperm during the cryopreservation process. These containers usually are not reused, generating highly polluting waste for the environment. Furthermore, in some countries, the containers usually used are sold by a few industries, which makes acquisition difficult and increases the product's price. Thus, the main objective of the thesis was to create and test low-cost methodologies that enhance the use of fish post-thaw sperm and make the sperm cryopreservation process more environmentally friendly. The experiments in the Chapters 1 and 2 were developed in Brazil. We used the South American silver catfish Rhamdia quelen, a species considered an experimental model for native South American fishes. In Chapter 1, we tested the use of post-thawing dilution to reduce the toxicity of the cryoprotectant solution. This technique is commonly used in mammalian sperm cryopreservation protocols but has never before been applied to post-thaw sperm of South American fishes. South American silver catfish post-thaw sperm samples were diluted in a saline extender (1.1% NaCl - 325 mOsm kg-1; pH 7.6). The post-thaw sperm diluted samples showed higher velocities, straightness, progression, and flagellar beat frequency than the cells of undiluted samples (control). The post-thawing dilution also provided higher fertilization and hatching rates than the control group. Thus, the post-thawing sperm dilution proved to be a simple, cheap, and efficient methodology that should be included in the silver catfish sperm cryopreservation protocol. In Chapters 2 and 3, we developed, tested, and described the methodology for using biodegradable gelatin (collagen) and hypromellose (HPMC) capsules as an alternative container to plastic straws in the fish sperm cryopreservation. In the second chapter, we observed that the biodegradable capsules maintained the kinetic parameters and reproductive capacity of South American silver catfish sperm just as effectively as plastic straws. The experimental procedures in Chapter 3 were carried out in Spain. We apply the methodology developed in Chapter 2 to the cryopreservation of sperm from European eel Anguilla anguilla, gilthead seabream Sparus aurata, and European sea bass Dicentrarchus labrax. In these three species, biodegradable capsules preserved the sperm kinetic parameters and membrane integrity just as effectively plastic straws. We observed that DNA damage in European eel and European sea bass sperm samples cryopreserved in capsules and straws did not differ. On the other hand, gilthead seabream sperm samples showed higher DNA damage than those cryopreserved in straws. However, the damage level observed in samples stored in capsules is considered low, thus, may not compromise embryonic development. We observed the results and concluded that biodegradable gelatin and HPMC capsules could be used as alternative containers to plastic straws for sperm cryopreservation from the tfour aquaculture fishes. / This study was supported by MICINN with funding from European Union NextGenerationEU (PRTR-C17.I1) and by Generalitat Valenciana (THINKINAZUL/2021/012;THINKINAZUL/2021/024;THINKINAZUL/2021/042) including the contract of FF-G.WAG-L has a Margarita Salas postdoctoral contract (RD 289/2021. UAB) by the Spanish Ministry of Universities. LF has a PhD contract from Generalitat Valenciana (GRISOLIAP/2020/063). TSF (141717/2019-0 and 200285/2021-1) and MPS (200452/2022-3) have fellowships from Brazilian National Council for Scientific and Technological Development (CNPq). / De Souza França, T. (2024). Development and Application of Low-Cost and Environment-Friendly Techniques for Fish Sperm Cryopreservation [Tesis doctoral]. Universitat Politècnica de València. https://doi.org/10.4995/Thesis/10251/204486 / Compendio

Submitted by Sara Ribeiro (sara.ribeiro@ucb.br) on 2017-11-09T12:35:25Z No. of bitstreams: 1 FabyanoAlbertoStalschmidtPrestesDissertacao2017.pdf: 1400128 bytes, checksum: 09760223aaa6e27dd73ff4e19e8dc8e9 (MD5) / Approved for entry into archive by Sara Ribeiro (sara.ribeiro@ucb.br) on 2017-11-09T12:36:23Z (GMT) No. of bitstreams: 1 FabyanoAlbertoStalschmidtPrestesDissertacao2017.pdf: 1400128 bytes, checksum: 09760223aaa6e27dd73ff4e19e8dc8e9 (MD5) / Made available in DSpace on 2017-11-09T12:36:23Z (GMT). No. of bitstreams: 1 FabyanoAlbertoStalschmidtPrestesDissertacao2017.pdf: 1400128 bytes, checksum: 09760223aaa6e27dd73ff4e19e8dc8e9 (MD5) Previous issue date: 2017-11-26 / The discussion that unveils the aspects related to the access to justice is relevant, bearing in mind that a new look to the problems that blur this right is necessary, which must be bequeathed to all citizens. In the light of this conceptions the present work brought as general objective the analyzes of tools to make the judiciary management more efficient. To reach the stablished objective, a work that presented compatible scientific method as elected subject was developed, specially the deductive, to particular issues, from general concepts extracted of the bibliographical research, and the inductive to conclusion making. The data analyzed with the bibliographical research and the statistical data contemplate that the State obligation is not synthesized into a mere jurisdictional response, but yet, to the provision of an effective protection, that respects the guiding principle of all the Brazilian judicial system, which is the free access to justice, but also that serves the constitutional principle of a reasonable length process provided as individual right in the Federal Constitution. Therefore, it demonstrates that the ado in the provision of judicial protection, and the lack of structure of the Judiciary Branch constitute a contemporary problem, capable of generating lengthy process, inefficient and unfair, turning the access to justice a chimera that is not harbored by the celerity, but yet, by the lengthening process. Furthermore, the judicial services made available to the society, must be charged in a reasonable way to respond the aspirations of the user and be viable to the State bear the costs in a rational way. The whole limiting context to justice in Brazil is a triggering event in the delay of the conflict effective resolution, and contemplates the increase in costs of process, reducing the trust that the society has for the Judiciary Branch and in the protection of their rights. It was concluded that the reengineering of judiciary management is a crucial instrument to the improvement of judicial service rendering, specially, as incentive to all means of extrajudicial conflict arbitration. / A discuss??o que descortina os aspectos relacionados ao acesso ?? justi??a se faz pertinente, tendo em vista que ?? necess??rio um novo olhar para os problemas que enevoam este direito, que deve ser legado a todos os cidad??os. A luz destas concep????es o presente estudo trouxe como objetivo geral analisar ferramentas para tornar mais eficaz a gest??o judici??ria. Para o alcance do objetivo tra??ado foi desenvolvido um trabalho que apresentou m??todos cient??ficos compat??veis com o tema eleito, especialmente o dedutivo, para quest??es particulares, a partir de conceitos gerais separados da pesquisa bibliogr??fica, e o indutivo para a tomada de conclus??es. Os dados analisados com a pesquisa bibliogr??fica e dados estat??sticos contemplam que o dever do Estado n??o se resume a uma mera resposta jurisdicional, mas sim, a presta????o de uma tutela efetiva, que respeite o princ??pio norteador de todo o sistema judicial brasileiro, que ?? o livre acesso ?? justi??a, mas tamb??m que atenda ao princ??pio constitucional da razo??vel dura????o do processo previsto como direito individual na Constitui????o Federal. Isto posto, traz-se a lume que a demora na presta????o da tutela jurisdicional e a falta de estrutura do Poder Judici??rio constituem problemas da contemporaneidade, capazes de gerar um processo lento, ineficaz e injusto, tornando o acesso ?? justi??a uma quimera que n??o encontra guarida na celeridade e, sim na morosidade processual. Al??m disso, os servi??os de justi??a colocadas ?? disposi????o da sociedade, devem ser cobrados de forma razo??vel para atender aos anseios dos usu??rios e de forma racional para ser vi??vel para o Estado arcar com estas despesas. Todo o contexto limitador do acesso ?? justi??a no Brasil ?? fato gerador de demora na efetiva resolu????o da lide, e contempla o aumento do custo do processo, reduzindo a confian??a que a sociedade tem no Poder Judici??rio e na prote????o de seus direitos. Concluiu-se que a reengenharia da gest??o judici??ria ?? instrumento fundamental para a melhoria da presta????o dos servi??os de justi??a, especialmente, com o incentivo dos meios de concilia????o de conflitos extrajudiciais.

Introduction: The objective of this study is to investigate the role of osteoblasts in the pathophysiology of premature suture fusion in infants. Methods: Bone and periosteal tissue from fused and patent cranial sutures and adjacent bone were harvested from infants undergoing surgery for craniosynostosis and used to develop primary osteoblast cell cultures. Dural tissue was obtained from neurosurgical procedures in order to generate an osteoblast-dural co-culture. Osteoblast proliferation, differentiation, mineralization, protein expression (Noggin, BMP3 and Runx2) and response to exogenous FGF2 stimulation were assessed. Results: Cell cultures demonstrated significant (p<0.05) regional variations in osteoblast proliferation, differentiation markers and in vitro bone nodule formation. The expression of anti-osteogenic molecules (Noggin and BMP3) was decreased in osteoblasts from fused suture regions. Conclusion: The creation of a pro-osteogenic environment through the decreased expression of anti-osteogenic signalling molecules and increased expression of osteogenic factors may be responsible for premature suture fusion in infants.

Introduction: The objective of this study is to investigate the role of osteoblasts in the pathophysiology of premature suture fusion in infants. Methods: Bone and periosteal tissue from fused and patent cranial sutures and adjacent bone were harvested from infants undergoing surgery for craniosynostosis and used to develop primary osteoblast cell cultures. Dural tissue was obtained from neurosurgical procedures in order to generate an osteoblast-dural co-culture. Osteoblast proliferation, differentiation, mineralization, protein expression (Noggin, BMP3 and Runx2) and response to exogenous FGF2 stimulation were assessed. Results: Cell cultures demonstrated significant (p<0.05) regional variations in osteoblast proliferation, differentiation markers and in vitro bone nodule formation. The expression of anti-osteogenic molecules (Noggin and BMP3) was decreased in osteoblasts from fused suture regions. Conclusion: The creation of a pro-osteogenic environment through the decreased expression of anti-osteogenic signalling molecules and increased expression of osteogenic factors may be responsible for premature suture fusion in infants.

This thesis investigates space through its relationship with society based on the idea of the social production of space. By employing the social concepts of community and institution, and the spatial concepts of shelter space and marker space, it provides a theoretical perspective for the evaluation of space in architectural history. This theoretical frame is supplied with a case study on the evolution of Early Christian community and their meeting place. The historical course of the Early Christianity in the Roman Empire from community formation to become an institution &ndash / Christendom - constitutes the paradigm for the social premise of the thesis. On the other hand, the proposed outline for the spatial evolution is demonstrated on the house-church at Dura-Europos.

Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em Neurociências. / Made available in DSpace on 2012-10-22T00:07:50Z (GMT). No. of bitstreams: 0 / Foi avaliado o efeito da dotarizina (10 mmo/Kg, i.v.), um bloqueador de canais de cálcio, sobre o extravasamento plasmático induzido pela substância P (10 nmol/Kg, i.v.), bradicinina (1 nmol/Kg, i.v.) e serotonina (300 nmol/Kg, i.v.) na dura-máter e sistema nervoso central de ratos (cerebelo e córtex). A substância P, a bradicinina e a serotonina, aumentaram o extravasamento plasmático na dura-máter de modo dose relacionado, sem alterar o extravasamento plasmático basal no cerebelo e córtex. O pré-tratamento com dotarizina bloqueou o extravasamento plasmático induzido por estes mediadores inflamatórios na dura-máter de ratos.