The Agile method has since it got published, of many been regarded as the universal solution to increased flexibility in software development. Scrum is, without a doubt, the most widely used Agile method among software development teams. Nonetheless, there are many challenges with the Scrum method, and therefore, success factors need to be identified to make up for its weaknesses. Lack of enthusiasm or events being time-consuming is some of the challenges the team faces with the framework, which can result in its members only using Scrum partially. For that reason, the main objective of this thesis is to identify which parts of Scrum are most commonly skipped by the members of an Agile development team for software, and why. In the initial study, a content analysis was conducted to examine how people in forums and on social media express themselves regarding Scrum, to identify the most common objections to the framework. The conclusion of the work was that the sprint review was identified as the most common event to skip, and the number one reason for skipping an event was that it felt unnecessary. Sprint planning was the step seen as giving the most negative consequences when skipped, and some of the risks of skipping a step were that it could give less oversight, a low feedback cycle, and a lack of communication, and collaboration. A positive outcome of skipping an event was that it allowed for more time to work, to get an uninterrupted flow and less overhead. To get an even better insight into the Scrum team’s daily work, the future study would be to perform a case study for an in-depth, detailed examination of the challenges with Scrum.

Introduction: Bivalirudin and heparin are the two most commonly used anticoagulants used during Percutaneous Coronary Intervention (PCI). The results of Randomized Controlled Trials (RCTs) comparing bivalirudin versus heparin monotherapy in the era of radial access are controversial, questioning the positive impact of bivalirudin on bleeding. The purpose of this systematic review is to summarize the results of RCTs comparing the efficacy and safety of bivalirudin versus heparin with or without Glycoprotein IIb/IIIa Inhibitors (GPI). Methods: This systematic review was performed in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses PRISMA statements for reporting systematic reviews. We searched the National Library of Medicine PubMed, Clinicaltrial.gov and the Cochrane Central Register of Controlled Trials to include clinical studies comparing bivalirudin with heparin in patients undergoing PCI. Sixteen studies met inclusion criteria and were reviewed for the summary. Findings: Several RCTs and meta-analyses have demonstrated the superiority of bivalirudin over heparin plus routine GPI use in terms of preventing bleeding complications but at the expense of increased risk of ischemic complications such as stent thrombosis. The hypothesis of post-PCI bivalirudin infusion to mitigate the risk of acute stent thrombosis has been tested in various RCTs with conflicting results. In comparison, heparin offers the advantage of having a reversible agent, of lower cost and reduced incidence of ischemic complications. Conclusion: Bivalirudin demonstrates its superiority over heparin plus GPI with better clinical outcomes in terms of less bleeding complications, thus making it as anticoagulation of choice particularly in patients at high risk of bleeding. Further studies are warranted for head to head comparison of bivalirudin to heparin monotherapy to establish an optimal heparin dosing regimen and post-PCI bivalirudin infusion to affirm its beneficial effect in reducing acute stent thrombosis.

Analysis of spontaneous adverse events reports of Infanrix hexa vaccine Author: Klára Kovaříková Supervisor: PharmDr. Eva Zimčíková, Ph.D. Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Introduction: Infanrix hexa vaccine is used for vaccination of infants and toddlers against diphtheria, tetanus, pertussis, hepatitis B, poliomyelitis and disease caused by Haemophilus influenzae type b. Analysis of spontaneous adverse drug reactions (ADRs) reports is one of the most important sources of information to evaluate drug-related risks. Objective: The aim of this study was to analyse spontaneous ADRs reports of Infanrix hexa vaccine, which were sent to the State Institute for Drug Control (SÚKL) database in the period from 2004 to 2017. Methods: The data was analysed using descriptive statistic in MS Excel. ADRs were classified according to the MedDRA. Seriousness and expectedness of ADRs were evaluated. Results: Overall 1288 reports were obtained containing 4334 ADRs, approximately 3.4 ADRs per report. Infanrix hexa vaccine was the only suspected drug in most of the reports (75.9%). Physicians were the most frequent reporters (70.2%). Serious ADRs were found in 84.3% of reports. The most frequent ADRs were general disorders and administration site...

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Introduction: Statements of commitment to change are commonly used to evaluate continuing medical education. However, this approach is new to evaluating the continuing professional development (CPD) of other health care practitioners such as audiology, speech-language therapy, occupational therapy, and physiotherapy in low- and middle-income countries. This study explored the use of Personal Commitment (to change) Statements (PCSs) as an evaluation tool of continuing education for health professionals in low- and middle-income countries, and its impact on the integration of new knowledge and skills with previous knowledge and clinical practice. Methods: PCSs were used in a case study conducted at a 1-day interprofessional CPD event held for health practitioners in South Africa. A qualitative thematic analysis was made of these PCSs, and results were synthesized into main themes. Results: Thirty-two participants turned in a PCS at the end of the CPD event with a total of 71 text statements. Three main domains were identified: (1) applying new knowledge in practice (61.97%); (2) increasing training-related content knowledge (21.12%); and (3) sharing information, skill, and resources (16.9%). Discussion: This study demonstrated that personal commitment statements can be used to describe the outcomes of CPD events for audiologists, speech-language, occupational, and physiotherapists. Participants engaged in reflection generated by the personal commitment statement, which contained no guiding statements, yet elicited responses showing that participants were more aware of the assessment tools and how they could use them in practice. Further study is warranted into the process and the role of follow-up regarding health practitioners' commitment to change in clinical practice.

These four stories are stories about life. The central characters are at a time in their lives when decisions become crucial and they have to act or become lost. Each of the dominant characters has experienced something in life that was beyond their control and they haven't recovered. These stories bring out and explore their recoveries. They are stories of rediscoveries of the self. In the story Gray, Margaret, is not in control of her life. She has had the trauma of losing her only daughter, and there is the intervention of a family friend who has only greed at heart. Margaret and her husband cannot cope and their situation is rapidly moving out of their control. Margaret discovers inner strength, and in her own subtle way, conveys this to her husband. She rebounds from the death of her daughter by becoming stronger herself. In the end, she has found peace within herself and the grief will take a more natural course. The characters in Revenge, parody people in repressed situations. The three women, a farce on three fairy tales, are out for revenge. They comically plot the deaths of the men who have repressed them. Their feminist attitudes lead them through adventures until, at last, they are free. Red Hood, Locks, and Beauty represent women who when bonded together become strong. They gain support from one another and then have the courage to act out their plans. Monica in A Strangled Cry, is not quite so strong. She has a history of problems. These problems are being compounded without her knowledge. She is repressed and controlled by Jeff, her doctor. She finally reaches a point where she knows that she either has to break free of the downward spiral of her life or give in to it forever. She cannot do it alone, however, and she has the help of her brother zack for her final escape. Finally, in Nine Lives, Katherine is in a relationship which is keeping her repressed. She tries to escape but cannot seem to. Finally she relies on help from her mother and her mother's attorney to help her flee from her abusive husband. She achieves her freedom after a long and trying escape. All four of the stories are a brief outlook on a side of life. The main characters have to make decisions which will affect the rest of their lives. The decisions are not always completely conscious or deliberate, but the results are consequential.

Markov chains are a fundamental subject of study in mathematical probability and have found wide application in nearly every branch of science. Of particular interest are finite-state Markov chains; the representation of finite-state Markov chains by a transition matrix facilitates detailed analysis by linear algebraic methods. Previous methods of analyzing finite-state Markov chains have emphasized state events. In this thesis we develop the concept of a transition event and define two types of transition events: cumulative events and time-average events. Transition events generalize state events and provide a more flexible framework for analysis. We derive computable, closed-form expressions for the expectation of these two events, characterize the conditioning of transition events, provide an algorithm for computing the expectation of these events, and analyze the complexity and stability of the algorithm. As an application, we derive a construction of composite Markov chains, which we use to study competitive dynamics.

Residents are main actors in the context of publicly funded sport events due to their role as taxpayers, and the importance of their support in an event’s success. The use of taxpayer dollars for hosting sport events is typically justified by event proponents (e.g., the local government) by highlighting purported positive event outcomes for the community. The extent to which such outcomes are attained may therefore influence the relationship between residents and their local government. Thus, the purpose of this dissertation was to investigate the long-term outcomes of publicly funded, non-mega sport events, and to examine the role of trust, knowledge, and power in the public/government relationship and event support in relation to these outcomes. To achieve this purpose, I focused on two publicly funded non-mega sport events, specifically the 2011 and 2019 Canada Winter Games, and drew on agency theory. The project progressed through three phases of research, each culminating in a research article. The first phase involved outlining the theoretical approach taken for this project. Next, I investigated the event objectives and long-term outcomes from resident and event provider perspectives. Finally, I investigated the public/government relationship by determining factors that predict general political trust and event support. The first article explains how agency theory, and the concepts of power, knowledge, and trust can be used to investigate political implications of publicly funded sport events. The second article suggests that while most residents evaluated their respective event positively, the interests of residents and event providers regarding event objectives and outcomes diverge. The final article revealed that event experiences positively predicted event support three- and 11-years following the event, and that residents’ power (i.e., ability to influence) negatively predicted political trust, while knowledge (i.e., understanding) positively impacted political trust in the event context. The three articles are preceded by a general introduction and are wrapped-up by a concluding chapter. Cumulatively, the results demonstrate that actors within the context of a publicly funded non-mega sport event may act as principals and agents in various moments of the event hosting process. Further, findings suggest that ensuring host residents are informed of the event will foster trust in the local government, and that community-focused tangible outcomes in particular will foster event support. This dissertation contributes conceptually and empirically to sport event management literature by taking a long-term post-event perspective on publicly funded, non-mega sport events. Practically, event providers should ensure that residents are fully informed of the event hosting process, and should ensure that tangible, and sustainable event outcomes occur as these seem to impact the most residents in a host community even from a long-term perspective. Finally, this work outlines the need for future research addressing methodological challenges in non-mega sport event research, investigating opportunism and monitoring in principal-agent relationships, and determining appropriate public engagement strategies for sustainable event outcomes.

Using scantling codes such as DNV or ISO for designing high speed craft has been a routine for many constructors. However, the validity of these design methods are to be questioned, especially when dealing with modern material concepts and structural layouts, since they are based on data from ships designed in the 1960ies and 1970ies using semi-empirical methods containing substantial uncertainties and limitations. For direct assessment of loading conditions, modern methods such as CFD are appreciated. But they consume lots of time and resources in the design stage, which makes efficiency worse. A simulation approach making detailed assessment of loading conditions and structural behavior for high speed craft in waves has been developed at KTH Royal Institute of Technology in Sweden, with parts of the method still in need of further validation. In the here presented project an experimental setup has been developed for detailed validation of simulated local structural responses for high-speed craft in waves. The experimental setup consists of a model structure instrumented with strain gauges and pressure sensors that is integrated into a high speed craft model. Experimental data has been generated through experiments in regular and irregular waves in the towing tank at University of Naples “Federico II”. The model structure and generated data are concluded to be feasible for the intended validation.

Data conversion for evolving events in an Event Sourcing System is a complex issue and needs to be maintainable. There are suggested ways handling data conversion today which combine different methods into a framework. However, there is a lack of exploration of different and alternative methods to handle the complicated matter.This thesis explores data conversion with fine-grained events. The purpose is to explore methods and broaden knowledge for handling data conversion while using attribute driven events called fine-grained events. The goal was to build a proof-of-concept that preserves the attributes reliability and availability and can handle data conversion of these specific events.The results found by using fine-grained events are a decrease in terms of system complexity and a proof-of-concept that maintains the desired attributes. / Datakonvertering för utvecklande händelser i ett Event Sourcing System är en komplex fråga som kräver att systemet är enkelt underhållning. Det finns förslag på sätt att hantera datakonvertering idag, vilket kombinerar olika metoder i ett ramverk. Det finns emellertid en brist på undersökning av olika och alternativa metoder för att hantera den komplexa orsaken.Denna avhandling undersöker datakonvertering med finkorniga händelser. Syftet är att utforska metoder och utvidga kunskap för hantering av datakonvertering genom att använda attributdrivna händelser som kallas finkorniga händelser. Målet var att bygga ett proof-of-concept som bevarar egenskaperpålitlighet och tillgängligt och som dessa specifika händelser.även hanterar datakonvertering förResultaten som hittas genom att använda finkorniga händelser är en minskning av systemkomplexiteten och ett bevis på koncept som upprätthåller de önskade egenskaperna.