Com o objetivo de estudar os possíveis efeitos da administração sistêmica de glutamina ou da associação de hidrocortisona, dimetilsulfóxido, ácido ascórbico e pentoxifilina nas lesões de isquemia e reperfusão no cólon maior, foram utilizados dezoito equinos. Sob anestesia geral e controle da oximetria de pulso e pressão arterial, os equinos foram submetidos a laparotomia e em um segmento do cólon maior foi induzida isquemia venosa total. Após uma hora de isquemia, seis equinos do Grupo G receberam glutamina (25mg/Kg IV), seis equinos do Grupo A receberam uma associação de hidrocortisona (4mg/Kg IV), dimetilsulfóxido (20mg/Kg IV), ácido ascórbico (50mg/Kg IV), e pentoxifilina (10mg/Kg IV) e os seis equinos do Grupo C receberam apenas solução de Ringer com lactato e constituíram o Grupo controle. Após duas horas de isquemia o fluxo sanguíneo local foi restabelecido. Decorridas duas horas de reperfusão foi realizada a laparorrafia e permitiu-se a recuperação anestésica. Seis horas após o início da reperfusão os equinos do Grupo G receberam novamente 25mg/Kg de glutamina, enquanto os equinos dos Grupos A e C receberam apenas solução de Ringer com lactato. Doze horas após o início da reperfusão os equinos foram eutanasiados. Foram colhidas amostras de cólon antes da indução da isquemia, após duas horas de isquemia e após duas e doze horas de reperfusão, que foram submetidas a avaliação histomorfológica, ultra-estrutural e determinação da atividade de mieloperoxidase. Os resultados para todas as variáveis estudadas foram semelhantes entre os grupos, permitindo concluir que os tratamentos, nas condições em que foram empregados neste estudo, não foram eficazes em atenuar as alterações decorrentes de isquemia e reperfusão no cólon maior de equinos. / This study was designed to evaluate the effects of intravenous administration of glutamine or the association of hydrocortisone, dimethyl sulphoxide, ascorbic acid and pentoxifylline on ischemia reperfusion lesions of the large colon. A segment of the large colon was isolated in 18 horses under inhalant general anesthesia and total venous ischemia was induced. One hour after the onset of ischemia, glutamine (25mg/Kg IV) was administered to six horses (G group), an association of hydrocortisone (4mg/Kg IV), dimethyl sulphoxide (20mg/Kg IV), ascorbic acid (50mg/Kg IV) and pentoxifylline (10mg/Kg IV) was administered to six horses, and the others received only isotonic fluids and remained as the control group (C). After 2 hours of ischemia and 2 hours of reperfusion the abdomen was closed and the horses were allowed to recover from anesthesia. After 6 hours of reperfusion, horses of group G received another dose of glutamine (25mg/Kg IV) whereas groups A and C received only isotonic fluids. Horses were euthanatized 12 hours after reperfusion. Biopsies were taken from the large colon before and after 2 hours of ischemia and after 2 and 12 hours of reperfusion. Alterations were evaluated under light and scanning electronic microscopy and scored. Additionally, mieloperoxidase (MPO) activity was measured. Results showed that scores for mucosal lesion, edema, hemorrhage, neutrophil infiltration and MPO activity during IR were similar between groups G, A and C. It was concluded that treatments were not effective in attenuating effects of ischemia and reperfusion in the equine large colon.

Submitted by Edisangela Bastos (edisangela@ufpa.br) on 2013-04-03T21:04:13Z No. of bitstreams: 2 license_rdf: 23898 bytes, checksum: e363e809996cf46ada20da1accfcd9c7 (MD5) Dissertacao_TeoresTiocianatoUrinario.pdf: 24078223 bytes, checksum: 97f7ef975d2cd8d85efcdebf5c846a16 (MD5) / Approved for entry into archive by Ana Rosa Silva(arosa@ufpa.br) on 2013-04-05T14:03:09Z (GMT) No. of bitstreams: 2 license_rdf: 23898 bytes, checksum: e363e809996cf46ada20da1accfcd9c7 (MD5) Dissertacao_TeoresTiocianatoUrinario.pdf: 24078223 bytes, checksum: 97f7ef975d2cd8d85efcdebf5c846a16 (MD5) / Made available in DSpace on 2013-04-05T14:03:09Z (GMT). No. of bitstreams: 2 license_rdf: 23898 bytes, checksum: e363e809996cf46ada20da1accfcd9c7 (MD5) Dissertacao_TeoresTiocianatoUrinario.pdf: 24078223 bytes, checksum: 97f7ef975d2cd8d85efcdebf5c846a16 (MD5) Previous issue date: 2003 / A etiopatia da úlcera péptica apresenta diversos fatores que contribuem para a agressão à mucosa gastroduodenal, sendo que o hábito alimentar pode ser um fator desencadeante, a população paraense apresenta relevante característica quanto ao hábito alimentar, em decorrência da ingestão de alimentos derivados da mandioca contendo glicosídeos ciangênicos, sendo que este trabalho tem o objetivo de determinar os teores de tiocianato urinário em portadores de úlcera péptica considerando-se a presença de Helicobacter pylori e comparando com indivíduos sadios de acordo com o nível de ingestão destes alimentos. Para a determinação dos teores de tiocianato foi empregado o método espectrofotométrico (UV), sendo que os resultados obtidos apresentaram valores médios de 0.7619 ± 0.4859 mg SCN-/L, 0.9258 ± 0.5701 mg SCN-/L e 1.2467 ± 0.8236 mg SCN-/L naqueles com baixa, moderada e elevada ingestão de glicosídeos cianogênicos respectivamente, concluindo-se que o método empregado na culinária paraense é eficaz, os indivíduos portadores de úlcera péptica H. pylori (positivo) apresentaram teores de tiocianato médios de 0.4913 ± 0.3841 mg SCN-/L, enquanto que os H. pylory (negativo) valores de 0.2463 ± 0.2922 mg SCN-/L, portanto, a ingestão de glicosídeos cianogênicos não interferiu no crescimento da bactéria no trato gastrintestinal. / The ethyopathogeny of the peptic ulcer presents diverse factors that contribute for the aggression to the gastroduodenal mucosa, being that the alimentary habit can be an unleash factor, the paraense population presents excellent characteristic how much to the alimentary habit, in result of the food ingestion derived from the cassava contends cyanogenic glycosides, being that this work has the objective to determine of urinary thiocyanate concentration in carriers of peptic ulcer being considered the presence of Helicobacter pylori and comparing with healthy individuals in accordance with the level of ingestion of these foods. The used analytical method was spectrophotometry (UV), being that the gotten results had presented average values of 0.7619 ± 0,4859 mg SCN-/L, 0,9258 ± 0,5701 mg SCN-/L and 1,2467 ± 0,8236 mg SCN-/L in those with low, moderate and hide ingestion of cyanogenic glycosides respectively, concluding itself that the method used in the paraense food is efficient, the carrying individuals of peptic ulcer H. pylori (positive) had presented average texts of thiocianate of 0.4913 ± 0.3841mg SCN-/L, while that the H.pylori (negative) values of 0.2463 ± 0,2922 mg SCN-/L, therefore, the ingestion of cyanogenic glycosides did not intervene with the growth of the bacterium in the gastrintestinal treatment.

Made available in DSpace on 2016-04-28T20:15:26Z (GMT). No. of bitstreams: 1 2007-Tiago Marques dos Santos.pdf: 2575604 bytes, checksum: e88af70c2740e40f39ed1fb8bd423ec5 (MD5) Previous issue date: 2007-02-26 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior / This work aimed to evaluate gastrointestinal and systemic disturbances, and mucosa and gut contents of gastrointestinal tract of horses subjected to overload carbohydrate. Eight crossbreed mature horses were used with body weight (BW) average of 364kg, geldings, adapted to diet composed by grass hay and concentrate, in a 60:40 proportion. A complete randomized design was used with horses allocated in three treatments. Treatment I: (Control) (n=2) horses were slaughtered without overload carbohydrate; Treatment II (n=3) and III (n=3), horses subjected to overload carbohydrate, with gastric infusion of 17.6 g starch/kg BW, and slaughtered after 24 and 36 hours, respectively. Horses were subjected to clinical, hematological and fecal evaluations before the overload and 2, 4, 8, 12, 16, 20, 24, 28, 32 and 36 hours after overload. Four hours after overload horses became depressed and keeping until the end of evaluation, and one horse presented lameness 36 hours after overload. Any difference (P>0.05) were observed in heart rate, respiratory rate, body temperature and hoof temperature. Increase in packed cell volume and plasma protein concentration were observed 24 hours after overload, varying from 26.7 to 32.0% and 7.1 to 8.1 g/dL, respectively (P<0.05). Differences were observed (P<0.05) in plasmatic lactate concentration in zero, 20 and 28 hours after overload, with values of 0.7, 1.04 and 1.22 mmol/L, respectively. Plasma endotoxin concentration didn't cross 0.1000 EU/mL and may be not present. There were any difference (P>0.05) in fecal and digesta water content, however, fecal pH reduced along 36 hours post-overload (P <0.01), varying from 6.09 to 4.46. Content of large intestine in horses subjected to overload presented whitish-green color, milk aspect, with gas bubbles and acid odor. There weren t difference (P>0.05) in water content of feces and digesta, however, fecal pH reduced along 36 hours post-overload (P <0.01), varying from 6.09 to 4.46. Buffering capacity of ceco-colon digesta and feces were reduced in horses subjected to overload. Right dorsal colon, transverse colon and descendent colon were segments, except stomach, that presented lower pH values, varying from 4.49 to 4.56. Eosinophils infiltration were presented in mucosa and submucosa of all horses, however, only horses submitted to overload presented neutrophils and eosinophils leucocitoestase with neutrophils predominance restricted to large intestine. Tract gastrointestinal circulatory alterations observed were congestion, edema and lymphatic vessels dilatation, more evident in submucosa, with larger inflammatory cells infiltration in horses subjected to overload. Intestinal mucosa 36 hours after overload presented larger degree of imunorreactivity anti-myeloperoxidase, followed by horses evaluated at 24 hours after overload and control horses, varying from 2.7 to 4.0, 1.0 to 3.7 and 1.0 to 2.5, respectively. Overload carbohydrate in horses promoted intensive fermentation in ceco-colon, predisposing clinical disturbances, digesta alterations and mucosa and submucosa lesions at gastrointestinal tract of horses with light to moderate degree,36 hours after overload. / Este trabalho teve como objetivo avaliar as altera??es sist?micas, da mucosa e conte?do do trato gastrointestinal de eq?inos submetidos ? sobrecarga diet?tica com amido. Foram utilizados oito eq?inos adultos castrados, com peso vivo m?dio de 364 kg, adaptados a dieta composta por feno de Coastcross e concentrado, na propor??o de 60:40. Foi utilizado um delineamento experimental com tr?s tratamentos: Tratamento I (Controle) (n=2), eutan?sia dos animais sem sobrecarga com amido; Tratamentos II (n=3) e III (n=3), animais submetidos ? sobrecarga com amido, com infus?o g?strica de 17,6 g amido/kg de peso corporal e eutan?sia ap?s 24 e 36 horas, respectivamente. Os eq?inos foram submetidos a avalia??es cl?nicas, hematol?gicas e f?sico-qu?micas das fezes antes da sobrecarga e 2, 4, 8, 12, 16, 20, 24, 28, 32 e 36 horas p?s-sobrecarga. Os animais apresentaram-se ap?ticos quatro horas ap?s a sobrecarga permanecendo assim at? o final da avalia??o e apenas um animal apresentou claudica??o, 36 horas p?s-sobrecarga. N?o houve diferen?a (P>0,05) na freq??ncia card?aca, freq??ncia respirat?ria, temperatura corporal e temperatura dos cascos. Houve aumento (P<0,05) no volume globular e prote?na plasm?tica total, 24 horas p?s-sobrecarga, variando de 26,7 a 32,0% e de 7,1 e 8,1 g/dL, respectivamente. Houve diferen?a (P<0,05) na concentra??o plasm?tica de lactato no tempo zero, 20 e 28 horas p?s-sobrecarga, com valores de 0,7, 1,04 e 1,22 mmol/L, respectivamente. A concentra??o plasm?tica de endotoxinas n?o ultrapassou 0,1000 EU/mL, podendo estar at? mesmo ausente. O conte?do do intestino grosso nos eq?inos submetidos ? sobrecarga apresentou cor verde esbranqui?ada, aspecto leitoso, com bolhas de g?s e odor ?cido. N?o houve diferen?a (P>0,05) no teor de ?gua das fezes e do conte?do da digesta, no entanto, o pH fecal reduziu ao longo de 36 horas p?s-sobrecarga (P<0,01), variando de 6,09 a 4,46. Houve redu??o na capacidade de tamponamento das fezes nos eq?inos submetidos ? sobrecarga e, de forma similar, ocorreu no conte?do do ceco-c?lon. O c?lon dorsal direito, c?lon transverso e c?lon descendente foram os segmentos, com exce??o do est?mago, que apresentaram a digesta com menores valores de pH, variando de 4,49 a 4,56. ? histopatologia, a infiltra??o de eosin?filos esteve presente na mucosa e submucosa de todos os eq?inos, no entanto, somente em dois eq?inos submetidos ? sobrecarga, observou-se leucocitoestase de neutr?filos e eosin?filos, com predomin?ncia de neutr?filos no intestino grosso. As altera??es circulat?rias observadas no trato gastrointestinal foram congest?o, edema e dilata??o de vasos linf?ticos, sendo mais evidentes na submucosa, local de maior infiltra??o de c?lulas inflamat?rias nos eq?inos submetidos ? sobrecarga. A mucosa dos segmentos do trato gastrointestinal dos eq?inos eutanasiados 36 horas p?ssobrecarga apresentou maior grau de imunorreatividade anti-mieloperoxidase, seguido dos eq?inos avaliados 24 horas p?s-sobrecarga e dos eq?inos do tratamento controle, variando de 2,7 a 4,0, 1,0 a 3,7 e 1,0 a 2,5, respectivamente. A sobrecarga diet?tica com amido em eq?inos promove fermenta??o intensa no ceco-c?lon, predispondo ao aparecimento de dist?rbios cl?nicos, altera??es do conte?do da digesta e les?es de leve a moderada na mucosa e submucosa do trato gastrointestinal dos eq?inos, ap?s 36 horas da sobrecarga.

Submitted by Maria Aparecida (cidazen@gmail.com) on 2017-11-13T14:21:15Z No. of bitstreams: 1 Fábio Gomes Teixeira.pdf: 415617 bytes, checksum: 372db933a02a007f513b9a2d77a17362 (MD5) / Made available in DSpace on 2017-11-13T14:21:15Z (GMT). No. of bitstreams: 1 Fábio Gomes Teixeira.pdf: 415617 bytes, checksum: 372db933a02a007f513b9a2d77a17362 (MD5) Previous issue date: 2011-10-18 / Cohort study using retrospective data to evaluate the effectiveness of the treatment program for chronic hepatitis C in users of Farmácia Estadual de Medicamentos Excepcionais do Maranhão (FEME) to determine the rate of sustained virologic response (SVR) and correlate it with demographic, clinical, laboratory, histological and virological features of patients and to identify the rates of discontinuation of treatment. We analyzed data from 256 patients treated for chronic hepatitis C in FEME for the period January 2005 to July 2009, being an SVR by intention to treat 57%. Males predominated (66%). The mean age was 52.5 years, with a predominance of non-white individuals in relation to whites. Genotype 1 was the most common (77%) and 150 (58.6%) patients had viral load above 400,000 UI/ml. With respect to the treatment regimen, pegylated interferon associated with ribavirin was used by 80.5% of patients, the rate of discontinuation of treatment of 13,3%. They were identified as factors independently associated with SVR: white, non-cirrhotic, have not a genotype 1 and viral load below 400,000 IU / ml. These findings demonstrate the effectiveness of treatment provided by FEME, which makes it possible to cure most patients, preventing progression to end-stage liver disease and its disastrous consequences. The factors associated with SVR have seen in other studies, leads us to believe that the results are reliable and that the program is fulfilling the role it has set itself. / Estudo de coorte com dados retrospectivos com o objetivo de avaliar a efetividade do programa de tratamento da hepatite C crônica em usuários da Farmácia Estadual de Medicamentos Excepcionais do Maranhão (FEME), determinar a taxa de resposta virológica sustentada (RVS) e correlacioná-la com características demográficas, clínicas, laboratoriais, histológicas e virológicas dos pacientes, além de identificar as taxas de interrupção do tratamento. Foram analisados os dados de 256 pacientes, tratados para hepatite C crônica na FEME no período de Janeiro de 2005 a Julho de 2009, encontrando-se uma RVS por intenção de tratar de 57%. O sexo masculino foi predominante (66%). A média de idade encontrada foi de 52,5 anos, havendo predomínio de indivíduos não brancos em relação aos brancos. O genótipo 1 foi o mais comum (77%) e 150 (58,6%) pacientes apresentaram carga viral superior a 400.000 UI/ml. Com relação ao esquema de tratamento, o interferon peguilado associado ribavirina foi utilizado por 80,5% dos pacientes, sendo a taxa de interrupção do tratamento de 13,3%. Foram identificados como fatores independentemente associados à RVS : cor branca, não cirróticos, ter genótipo não 1 e carga viral abaixo de 400.000 UI/ml. Estes achados demonstram a efetividade do tratamento fornecido pela FEME, que possibilita a cura da maioria dos pacientes, prevenindo a progressão para doença hepática terminal e suas consequências desastrosas. A RVS associada a fatores já vistos em outros estudos, nos faz acreditar que os resultados são confiáveis e que o programa está cumprindo o papel a que se propôs.

Background and rationale for the study. This study investigated whether human immunodeficiency virus (HIV) infection adversely affects the prognosis of patients diagnosed with hepatocellular carcinoma (HCC).Thirty-four HIV-positive patients with chronic liver disease, consecutively diagnosed with HCC from 1998 to 2007 were one-to-one matched with 34 HIV negative controls for: sex, liver function (Child-Turcotte-Pugh class [CTP]), cancer stage (BCLC model) and, whenever possible, age, etiology of liver disease and modality of cancer diagnosis. Survival in the two groups and independent prognostic predictors were assessed. Results. Among HIV patients 88% were receiving HAART. HIV-RNA was undetectable in 65% of cases; median lymphocyte CD4+ count was 368.5/mmc. Etiology of liver disease was mostly related to HCV infection. CTP class was: A in 38%, B in 41%, C in 21% of cases. BCLC cancer stage was: early in 50%, intermediate in 23.5%, advanced in 5.9%, end-stage in 20.6% of cases. HCC treatments and death causes did not differ between the two groups. Median survival did not differ, being 16 months (95% CI: 6-26) in HIV positive and 23 months (95% CI: 5-41) in HIV negative patients (P=0.391). BCLC cancer stage and HCC treatment proved to be independent predictors of survival both in the whole population and in HIV patients. Conclusions. Survival of HIV infected patients receiving antiretroviral therapy and diagnosed with HCC is similar to that of HIV negative patients bearing this tumor. Prognosis is determined by the cancer bulk and its treatment.

No description available.

En la presente tesis se ha analizado la actividad hepática de una enzima (prolilhidroxilasa) que interviene en la síntesis del colágeno y la concentración sérica de un péptido (péptido aminoterminal del procolágeno tipo III) que se origina durante el proceso de síntesis del mismo en un grupo de pacientes con una hepatopatía alcohólica de diversa severidad diagnosticados por biopsia hepática y se ha observado una relación entre los niveles de actividad hepática de la prolil-hidroxilasa y la concentración sérica del péptido aminoterminal del procolágeno tipo III con la intensidad de la fibrosis hepática. También se ha hallado una relación lineal directa entre ambos parámetros lo que sugiere que ambos marcadores son índices de fibrosis y fibrogénesis hepatica en la hepatopatía alcohólica y podrían ser de utilidad en el control evolutivo de estos pacientes.

En trasplante hepático (TH), la lesión por isquemia-reperfusión (I/R) es la causa principal tanto del mal funcionamiento como del fallo primario del injerto hepático. Y si esto ocurre en hígados sanos, aun son mayores los casos de mal función o fallo primario cuando el injerto es esteatósico, ya que estos hígados toleran peor que los normales la lesión por I/R. Además, la esteatosis es la causa del mayor número de hígados no aptos para el trasplante, acentuando la problemática de la falta de injertos para TH. Por ello, es evidente la necesidad de desarrollar estrategias protectoras para minimizar los efectos adversos de la lesión por I/R en hígados esteatósicos. Los efectos perjudiciales del Sistema Renina-Angiotensina (RAS) y de la proteína transportadora de retinol tipo 4 (RBP4) en varias patologías están bien documentados pero no se sabe si estarían implicados en la lesión por I/R en TH. Por otro lado, el precondicionamiento isquémico (PCI) basado en la inducción de breves periodos de I/R, reduce la lesión por I/R asociada a TH, pero se desconocen en gran parte sus mecanismos protectores. En la presente tesis se investigó el papel del RAS y del RBP4 en la lesión por I/R en injertos esteatósicos y no esteatósicos sometidos a TH, así como su implicación en los beneficios del PCI. Además de esto, se evaluaron los mecanismos de protección de estrategias farmacológicas o quirúrgicas, como el PCI capaces de modular el RAS y el RBP4 en ambos tipos de injertos. Para alcanzar estos objetivos, se utilizó el modelo experimental de TH ortotópico utilizando ratas de la cepa Zucker. Los resultados obtenidos indicaron que la Angiotensina II, principal efectora del RAS, está implicada en la lesión por I/R en injertos hepáticos no esteatósicos, pero no en los beneficios del PCI. Asimismo se demostró que los antagonistas de los receptores de la Angiotensina II protegieron a los injertos no esteatósicos a través de la sobrerregulación de la ERK1/2. Estas estrategias no fueron de utilidad en presencia de esteatosis. En el caso de los injertos hepáticos esteatósicos se ha señalado por primera vez la implicación de la Angiotensina 1-7 (Ang 1-7), otro potente efector del RAS, en la lesión por I/R, demostrando propiedades perjudiciales de la Ang 1-7 no conocidas anteriormente. Además se describió un nuevo mecanismo protector del PCI, en el cual el PCI, a través de AMPK, induce la generación de RBP4, que a su vez reduce la sobre-expresión del PPARγ, protegiendo así a los injertos esteatósicos. Esto señaló por primera vez un efecto beneficioso del RBP4 que no había sido descrito anteriormente en ninguna patología. Adicionalmente, se describieron las siguientes estrategias terapéuticas específicas para los injertos esteatósicos: el antagonista del receptor de la Ang 1-7 redujo el daño trasplante, reduciendo asÍ la lista de espera en TH. Estos hallazgos también podrían contribuir a nuevas aplicaciones del PCI en la práctica clínica en TH, ya que los mecanismos protectores descritos del PCI refuerzan su papel como estrategia protectora y muestran al PCI como una estrategia quirúrgica sencilla que puede ejercer los mismos efectos beneficiosos que varias de las estrategias farmacológicas propuestas. / Numerous steatotic livers are discarded as unsuitable for transplantation because of their poor tolerance of ischemia-reperfusion (I/R). The injurious effects of renin-angiotensin system (RAS) and retinol-binding protein 4 (RBP4) in various pathologies are well documented. Ischemic preconditioning (PC) based on brief periods of I/R protects steatotic liver grafts against I/R injury, but the responsible mechanism is poorly understood. The aims of this doctoral thesis were: a) to investigate the role of RAS and RBP4 in I/R injury associated with non-steatotic and steatotic liver transplantation and the benefits of PC in such situations, and b) to examine protective mechanisms of pharmacological or surgical strategies such as PC, able to modulate RAS and RBP4 in both type of grafts. For this, Zucker rats were submitted to liver transplantation with or without preconditioning. Our results showed that Angiotensin II, the main effector of RAS, is involved in I/R injury in non-steatotic grafts, but not in the benefits of PC. Thus, Angiotensin II receptor antagonists protected non-steatotic grafts against damage and this protection was associated with ERK 1/2 over-expression. These strategies were ineffective in steatotic grafts. In the presence of steatosis, Angiotensin 1-7 (Ang 1-7), another effector of RAS, played a role in I/R injury in steatotic grafts. Additionally, it has been described that PC through AMPK, induced RBP4 and this in turn reduced PPARγ, thus protecting steatotic grafts against I/R injury. Results obtained herein also led to describe the following therapeutic strategies specific for steatotic grafts: Ang 1-7 receptor antagonists reduced hepatic damage through reduction of peroxynitrite formation; and therapies that induce RBP4, such as PCI of pretreatment with RBP4, as well as PPARγ antagonists, also protected steatotic grafts against I/R injury in liver transplantation. In terms of clinical application, these therapies might open new avenues for steatotic liver transplantation and improve the initial conditions of donor livers with low steatosis that are available for transplantation. Such therapies could also increase the use of numerous steatotic livers currently discarded for transplantation, thus reducing the risk of death of those patients on liver transplant waiting lists.

Resumo não disponível.

Dissertação (Mestrado) - Pontificícia Universidade Católicia do Paraná, Curitiba, 2009. / Bibliografia: f. 105-120 / Dentre as afecções gastrintestinais com implicações imunogenéticas destacam-se a doença celíaca (Dc) e a doença de Crohn (DC). Objetivos: Identificar e comparar o painel de autoanticorpos em portadores de Dc e DC e associá-los com doenças autoimunes (DAI´ / Celiac disease (Ced) and Crohn's disease (CD) and are good examples of diseases with genetic and immunological implications. There is a link between these diseases and other autoimmune disorders. Thus, it is interesting to determine a panel of autoantibod