Introdução: O Programa Bolsa Família é a principal estratégia brasileira para amenizar a pobreza e vulnerabilidade social, com diferentes impactos na vida dos beneficiários. O aumento da renda, em função do benefício, poderia trazer resultados positivos na alimentação, uma vez que possibilitam uma maior diversidade da dieta. Porém, poderia trazer resultados negativos como a ingestão excessiva de energia e consequente aumento da adiposidade. As avaliações dos impactos do programa em termos de obesidade e massa gorda de crianças são inexistentes. Objetivo: Avaliar o impacto do Programa Bolsa Família no estado nutricional (IMC/idade) e na composição corporal aos 6 anos de idade entre as crianças da Coorte de Nascimentos de Pelotas (RS), 2004. Métodos: Os dados foram provenientes da integração dos bancos da Coorte de Nascimentos de Pelotas de 2004 e do Cadastro Único do Governo Federal. Foi realizada análise descritiva da cobertura e focalização do programa, com informações do nascimento e dos 6 anos de idade (n=4231). Considerou-se focalização o percentual de elegíveis entre o total de beneficiários e cobertura o percentual de famílias elegíveis que são beneficiárias do programa. Nos modelos de impacto (n=3446), as exposições principais foram o recebimento do benefício: beneficiário em 2010, no período de 2004-2010; o valor médio mensal recebido e o tempo de recebimento. Foram gerados modelos de regressão linear para os desfechos score-Z do índice de massa corporal por idade (IMC/I), percentual e índice de massa gorda (IMG), e percentual e índice de massa livre de gordura (IMLG); e de Poisson, com ajuste robusto, para o desfecho obesidade (score-Z IMC/I 2), todos estratificados por sexo. As informações antropométricas e de composição corporal (BOD POD) foram obtidas do acompanhamento aos 6-7 anos de idade. Potenciais fatores de confusão foram identificados por modelo hierárquico e por um diagrama causal (DAG). Para analisar os impactos foram usadas como medidas de efeito a diferença de médias na regressão linear múltipla (IMC/I, por cento MG, IMG, por cento MLG e IMLG, variáveis contínuas) e a razão de prevalência (obesidade, variável binária). Para permanecer no modelo, considerou-se valor p0,20. A análise dos dados foi realizada por meio do software STATA. Resultados: Entre 2004-2010, a proporção de famílias beneficiárias na coorte aumentou (11 por cento para 34 por cento ) enquanto, de acordo com a renda familiar, a proporção de famílias elegíveis diminui (29 por cento para 16 por cento ). No mesmo período, a cobertura do programa aumentou tanto pela renda familiar quanto pelo IEN. Já a focalização caiu de 78 por cento para 32 por cento de acordo com a renda familiar e, de acordo com o IEN, manteve-se em 37 por cento . A média (não ajustada) de IMC e de MG dos não beneficiários foi superior a dos não beneficiários tanto em meninos quanto em meninas. Meninos do 3º tercil de valor per capita recebido e meninas com menos de 7 meses de benefício em 2010 tiveram IMC maior do que, respectivamente, aqueles dos demais tercis e daquelas com mais de 7 meses de benefício em 2010; esse padrão foi semelhante para obesidade. Meninas não beneficiárias tiveram MG maior do que as beneficiárias e superior também aos meninos, independente de ser beneficiário ou não. Em relação à MLG observou-se um comportamento contrário, no qual meninas beneficiárias tiveram maior MLG, quando comparadas com meninas não beneficiárias e, meninos quando comparados com meninas. Nos modelos de regressão ajustados, não houve diferença significativa entre beneficiários e não beneficiários em nenhum desfecho. Conclusões: De acordo com os resultados, as famílias que receberam maiores valores per capita parecem incluir crianças com maior média de IMC. O programa, nessa análise, parece não ter impacto sobre a composição corporal das crianças, nem em termos de massa gorda, tampouco em termos de massa livre de gordura. / Introduction: the Bolsa Família Program (BFP) is the main Brazilian strategy to alleviate poverty and social vulnerability, with different impacts on the lives of beneficiaries. The increase of income, depending on the benefit, could bring positive results in food consumption, since enable greater dietary diversity. However, it could bring negative results as excessive intake of energy and consequent increased adiposity. The evaluations of the impacts of the program in terms of obesity and fat mass of children are nonexistent. Objective: to evaluate the impact of BFP in nutritional status (BMI/A) and body composition to 6 years of age among children of the Cohort of Births of Pelotas (RS), 2004. Methods: data were obtained from the integration of the banks of the cohort of births of 2004 pellets and Single Record of the Federal Government. Descriptive analysis was performed of the coverage and focus of the program, with information of birth and 6 years of age (n=4231). Effect models (n=3446), the main exhibition were the approaches of the receipt of the benefit: beneficiary in 2010, in the 2004-2010 period; average monthly value and time of receipt. Linear regression models were generated for the Z-score outcomes of the body mass index for age illness (BMI/A), percentage and fat mass index (FMI), and percentage and fat-free mass index (FFMI); and Poisson, with robust adjustment for obesity outcome (score-Z BMI/A 2), all stratified by sex. The information and measurements of body composition (BOD POD) were obtained from monitoring to 6-7 years of age. Potential confounding factors were identified by hierarchical model and a causal diagram (DAG). The measures used were the average difference in multiple linear regressions (BMI/A, FM, FMI, FFM, FFMI, continuous variables) and the ratio of prevalence (obesity, binary variable). To stay at the model considered value p 0.20. Data analysis was performed using STATA software. Results: Between 2004-2010, the proportion of recipient families has increased (11 per cent to 34 per cent ); by family income eligible families number decreases (29 per cent to 16 per cent ). The coverage of the program increased both by family income as by IEN. The focus fell from 78 per cent to 32 per cent (household income) and remained at 37 per cent (IEN). The average (not adjusted) of BMI and FM of non-beneficiaries was higher in boys and girls. Boys of 3 tercil per capita value received and girls under the age of 7 months of 2010 had BMI greater benefit; this pattern was similar for obesity. Non-beneficiary girls had FM larger than the beneficiary and also higher than the boys, regardless of whether or not the beneficiary. Regarding the FFM observed a contrary behavior, in which beneficiaries girls had higher FFM, compared to non-beneficiary girls and boys compared to girls. In adjusted regression models, there was no significant difference between beneficiaries and non-beneficiaries in any outcome. Conclusions: there is evidence that the families who received largest per capita values include children with a higher average BMI. Although children beneficiaries have indexes under fat mass, the generated models showed that the program also has no effect on the fatfree mass.

Malgré leur potentiel important et leur introduction de plus en plus fréquente à différents niveaux politiques, le rôle des outils d’évaluation d’impact dans le processus politique reste questionné. Leur efficacité semble particulièrement limitée dans le cadre des problématiques comme la pauvreté et les inégalités sociales. Au-delà de leur complexité, c’est surtout le caractère controversé de ces phénomènes et le fait qu’il n’existe pas de consensus sur la manière d’aborder la pauvreté et les inégalités sociales, qui posent problème. Dans ce contexte, les connaissances issues d’une évaluation d’impact ne vont pas toujours jouer un rôle direct et instrumental dans la prise de décisions politiques.Dans cette thèse de doctorat, nous avons analysé comment adapter et améliorer le design et la mise en œuvre de l’outil de ‘Social Impact Assessment’ (ou de ‘Test d’impact pauvreté’), afin de mieux exploiter son potentiel d’aide à la décision en matière de lutte contre la pauvreté. Sur base d’une analyse (théorique et pratique) du fonctionnement des processus politique et décisionnels et des mécanismes de policy change, nous nous sommes intéressés aux différentes fonctions d’aide à la décision qu’il peut jouer. Nous avons identifié la fonction d’apprentissage instrumental comme la fonction la plus ‘consensuelle’ et attendue de la part des décideurs politiques, et la fonction d’apprentissage conceptuel comme la fonction potentiellement la plus puissante, mais souvent négligée et donc sous-exploitée.Via la fonction d’apprentissage instrumental, le test d’impact pauvreté doit apporter des informations précises et directement utiles à la décision. Dans cette perspective, l’accent est mis sur l’amélioration et l’optimalisation de la proposition politique, tout en respectant son cadre de référence, et en se concentrant sur ses aspects opérationnels. L’identification d’effets potentiels négatifs peut alors donner lieu à la formulation de propositions d’adaptation permettant d’atténuer voire compenser ces effets, tandis qu’un impact potentiel positif peut être davantage accentué et maximisé.Via la fonction d’apprentissage conceptuel, le test d’impact pauvreté devrait permettre d’introduire de nouvelles idées, perspectives et hypothèses qui contribuent à une compréhension plus élargie de la pauvreté, permettant ainsi de mieux appréhender les effets potentiels d’une politique sur la pauvreté. Dans cette perspective, le test d’impact pauvreté devrait contribuer, à plus long terme, à ce que les politiques publiques, quel que soit leur « secteur », puissent contribuer à une action politique globale efficace, pertinente et durable pour réduire (ou lutter contre) la pauvreté.Notre proposition de design pour le test d’impact pauvreté est guidée par le souci d’exploitation de ce double potentiel. Nous avons suivi une démarche itérative, dans laquelle nous avons développé une première proposition de design sur base (1) d’une revue de la littérature et (2) d’une analyse d’expériences en cours en matière d’évaluation d’impact sur la santé et la pauvreté en Irlande et au Québec (Canada). Cette proposition a été testée et appliquée concrètement dans des contextes de ‘real-world policy-making’. Nous avons effectué deux études de cas dans le contexte bruxellois :la première sur le projet d’ordonnance concernant le parcours d’accueil et d’intégration des primo-arrivants, la deuxième sur le projet d’assurance autonomie. Les observations faites sur le terrain, qui ont été confrontées avec des éléments issus de la littérature scientifique, ont permis d’adapter et affiner notre proposition.La proposition de design pour le test d’impact pauvreté est composée de quatre axes :(1) L’articulation du test d’impact pauvreté au timing et contraintes du processus politique et décisionnel ;(2) la clarification de ce que nous entendons par la ‘pauvreté’ et ‘l’impact sur la pauvreté’ et un schéma d’analyse des déterminants de la pauvreté, permettant d’identifier de quelle manière et à quel niveau une politique impacte la pauvreté ;(3) la proposition d’une démarche méthodologique d’évaluation, inspirée de l’approche de l’évaluation réaliste. Pour cet axe, nous avons défini une série de questions pour un test d’impact pauvreté ;(4) l’intégration des connaissances et de l’expertise des personnes en situation de pauvreté dans le test d’impact pauvreté. / Doctorat en Sciences de la santé Publique / info:eu-repo/semantics/nonPublished

Philosophiae Doctor - PhD / Validation of the OHIP-14 for a South African adult population using CFA resulted in a 12-item scale (OHIP-12) with excellent reliability (α =0.94), but the structural pathway varied across the socio-economic groups. The prevalence of oral pain was 19.4%, and varied significantly only across area-level SEP. Cost of care over the six months was estimated at about one billion Rand. Of those residing in the lowest SEP areas, 20.8% reported that they “did nothing” to relieve their last pain episode. Oral pain resulted in an average of two days lost per person from work/school over a six months period. The prevalence of OHIP was 16.2%. Those who had never visited a dental clinic had significantly better OHRQoL and less pain experience compared to those who previously visited a dental clinic. Both individual-level and area-level SEP were associated with OHRQoL in the bi-variate analysis, but these effects did not remain significant in multivariable-adjusted analysis. In particular, the respondents‟ race completely attenuated the effect of individual-level SEP on OHRQoL, while the experience of oral pain in the past six months completely attenuated the effect of area-level SEP on OHRQoL. Both absolute and relative inequality in oral health among the South African adult population was greater in the highest SEP areas than in the areas of lowest SEP

This thesis presents a case study of an open pit mine proposal in Kamloops, BC. During an integrated Environmental (Impact) Assessment (EA) process mandated by the Provincial and Federal governments, stakeholders addressed the mine’s environmental, social, heritage, economic, and health-related impacts. At the end of a 7-year process, the application was denied. My research sought to examine how health was conceptualized in the EA, and, specifically, had the mine been approved, how would the permit conditions have protected the public from adverse health effects. To that end, I conducted a review of health-related documents incorporated in the EA and studied the results through a Health Impact Assessment (HIA) lens based on guidance from the International Finance Corporation (IFC). As well as reviewing and analyzing the EA documents, I conducted interviews with participants in and outside the formal stakeholder group, as prescribed by the IFC HIA Guidance. Specifically, my analysis was based on the scoping phase of the assessment, and the baseline health profile that was included, using this internationally recognized HIA framework. My results show that the social determinants of health were not factored into the EA as per HIA best practice. Many in the formal stakeholder group, and outside of it, felt that institutional barriers prevented inclusion of the social determinants of health in the assessment. That finding raises questions about the reality of EA processes to protect public health. / Graduate

Cette enquête épidémiologique porte sur l'impact sanitaire de la décharge de Mbeubeuss, réceptacle de l'ensemble des déchets ménagers et industriels de Dakar (Sénégal), sur la population résidant à proximité. Les déchets, stockés sans être recouverts, sont source de pollution atmosphérique et des sols, notamment par le plomb et le cadmium. Les répercussions sanitaires sont d'autant plus préoccupantes que de nombreux riverains de cette décharge sont directement ou indirectement exposés. L'objectif de cette étude était de déterminer, après caractérisation chimique des échantillons de sol et de particules atmosphériques, l'imprégnation de la population (enfants et adultes) à ces deux métaux et de rechercher leur éventuel impact sur la fonction rénale. Nos résultats ont mis en évidence des teneurs atmosphériques et telluriques en plomb et en cadmium plus élevées sur le site de la décharge (teneurs 20 à 80 fois plus élevées que celles de la zone témoin). L'imprégnation saturnine, déterminée au travers des plombémies, plomburies et des marqueurs biologiques d'effet (PPZ, AlaU), de même que les teneurs sanguines et urinaires en cadmium étaient significativement plus importantes chez les individus résidant au voisinage de la décharge. La production excessive d'espèces réactives de l'oxygène induite par cette imprégnation s'est traduit par une diminution du système de défenses antioxydantes (SOD, GPx, Sélénium, GSH) et une peroxydation lipidique (MDA) accrue chez les sujets exposés. En outre, les variations de certains des marqueurs sensibles et spécifiques de néphrotoxicité (concentrations urinaires élevées en protéines totales, en RBP et en CC16 ; et augmentation des activités GSTα et LDH) suggèrent l'apparition de signes discrets et précoces d'altération de la fonction rénale chez les individus résidant à proximité de la décharge. L'exposition aux émissions de la décharge de Mbeubeuss constitue donc une véritable source de risques pour l'environnement et la santé des populations environnantes. Cette étude pourrait sans doute contribuer à conscientiser les acteurs de la santé sur les risques liés à cette décharge et à placer ces problèmes environnementaux, qui constituent un nouveau défi pour les pays pauvres, au cœur des futurs programmes de développement. / This case-control study dealt with adverse health effects on the population living near Mbeubeuss landfill in Dakar (Senegal). All household and industrial waste arising from Dakar are stored in this open landfill without being covered and are therefore possible sources of air pollution and soil contamination by heavy metals, especially Pb and Cd. Health impacts are of particular concern since many of the neighboring residents of this discharge are directly or indirectly exposed. The objective of this study was to determine Pb and Cd concentrations in both environment and humans, and to evaluate possible renal function alteration within the adult and child populations. Our results showed that lead and cadmium concentrations of soils and atmosphere were higher in the landfill (20 to 80 times) than those of the control area. The lead impregnation, evaluated through the blood and urine lead levals, and the biomarkers of exposure (PPZ, ALAU) as well as blood and urine cadmiums levels, were significantly higher in the subjects neighboring the landfill. Excessive production of reactive oxygen species induced by the metal impregnation conducted in exposed subjects to a decrease in antioxidant defense system (SOD, GPx, Selenium, GSH) and an increase in lipid peroxidation (MDA). Moreover, changes in several sensitive and specific markers of nephrotoxicity (high urinary concentrations of total protein, RBP and CC16, as well as GSTα and increased activities) suggested the occurence of discrete and early signs of impaired renal function for the landfill neighboring population. Exposure to emissions from the Mbeubeuss landfill is therefore a source of risk for the environment and the health of people who live and/or work within it. This study could undoubtedly help to raise awareness of landfill-related health risks amoung stakeholders, and to place these environmental problems, wich constitute a new challenge for poor countries, at the heart of future development programs.

En zone urbaine, la pollution atmosphérique représente un enjeu majeur de santé publique. La caractérisation du risque associé dépend fortement de la qualité de l’estimation des expositions. Si les études étiologiques s’appuient maintenant souvent sur des modèles ayant une résolution spatiale fine, les études d’impact sanitaire (EIS) reposent encore généralement sur des approches avec une faible résolution spatiale. Ces contrastes spatiaux pourraient entraîner des inégalités sociales dans la distribution de l’impact sanitaire des polluants atmosphériques. D’autres facteurs, et en particulier le bruit, partagent les mêmes sources et ont potentiellement des effets sur la santé, et devraient aussi être pris en compte dans les études épidémiologiques. Les objectifs étaient : 1. D’étudier la possibilité de modéliser la distribution des particules ultrafines (UFP) en milieu urbain, et d’évaluer la corrélation entre UFP et bruit ; 2. De réaliser une EIS des particules fines avec une résolution spatiale fine, et d’investiguer les inégalités socio-économiques dans le fardeau de maladie généré par les particules ; 3. D’estimer les bénéfices sanitaires de scénarios théoriques de réduction de la pollution de l’air à l’échelle urbaine.Le premier objectif fait partie du projet Tri-tabs, conduit dans les villes de Bâle, Gérone et Grenoble. Des mesures de 20 min du bruit routier et du trafic, mais pas des UFP, étaient fortement reproductibles sur plusieurs mois. Sur des mesures simultanées, la corrélation entre le bruit et les UFP était modérée, ce qui ouvre la possibilité d’un ajustement réciproque pour de futures études épidémiologiques, permettant ainsi de démêler leurs potentiels effets court terme.Le second objectif se focalise sur le long terme. La plupart du temps, les études d’impact sanitaire ne prennent pas en compte les variations spatiales des concentrations en polluants en zone urbaine. Dans les agglomérations de Grenoble et Lyon en 2012, l’exposition aux PM2.5 a été estimée à une échelle de 10×10 m en combinant un modèle de dispersion à des données de densité de population. Les événements de santé retenus étaient la mortalité ainsi que l’incidence du cancer du poumon (Grenoble) et des petits poids des naissances à terme. Les estimations de l’impact sanitaire ont été répétées en considérant les concentrations en polluants de façon homogène au sein de chaque agglomération. La proportion de cas attribuables à la pollution de l’air était de 3–8% pour la mortalité et 9–43% pour les petits poids de naissances à terme. A Grenoble, 6,8% des nouveaux cas de cancer du poumon étaient attribuables à la pollution de l’air. L’impact était sous-estimé de 8 à 20% lorsque les stations de mesure de fond étaient utilisées. Le risque attribuable était plus important dans les quartiers dont le niveau de défaveur sociale était intermédiaire ou légèrement au-delà.Nous avons estimé l’impact de scénarios de réduction des niveaux de particules fines. Les scénarios visant une réduction de ces niveaux de 5% permettraient une réduction d’environ 10% des décès attribuables aux particules, tandis que les actions visant à réduire uniquement la pollution chez les 10% d’habitants les plus exposés ne procureraient qu’un gain sanitaire marginal (environ 1%). En conclusion, nous avons montré que les mesures à court terme ne peuvent pas être utilisées pour modéliser les UFP en zone urbaine ; nous avons été parmi les premiers à réaliser une EIS s’appuyant sur un modèle de dispersion à résolution spatiale fine, et à avoir intégré les petits poids de naissances. Nos estimations ont montré que les stations de fond utilisées couramment en France pour les EIS tendent à sous-estimer les expositions, comparées à un modèle de dispersion. Notre estimation de la réduction des niveaux de particules fines nécessaire pour atteindre une réduction significative de l’impact sanitaire de la pollution de l’air en zone urbaine pourrait servir de guide à des politiques publiques. / In urban areas, atmospheric pollution represents a major threat to human health. The accurate characterization of this threat relies centrally on the quality of exposure assessment. It also requires assessment of other factors sharing the same sources and also possibly impacting health, such as noise. Fine-scale exposure assessment of air pollution levels may allow identifying spatial contrasts. Such spatial variations may lead to social differences in the distribution of the health impact of these pollutants.The general aims of the PhD were: 1. To study the possibility to model ultrafine particles distribution in urban areas and assess the correlation of ultrafine particles levels with road traffic noise; 2. To assess the risk incurred by air pollution exposure with a fine-scale modelling approach and investigate the potential socio-economic disparities in health burden induced by particulate matter; 3. To investigate the health benefits expected from hypothetical scenarios of reduction of air pollution levels at the urban scale.The first aim relies on Tri-tabs project, conducted in three European cities (Basel, Girona, Grenoble). Measurements during 20 minutes of outdoor noise and traffic, but not of UFP, were strongly reproducible over durations of a couple of days or months. In these areas, on the short-term, noise levels and UFP concentrations exhibited relatively moderate correlations, which may allow adjustment for mutual confounding in epidemiological studies, thus allowing to disentangle their possible short-term health effects.The second aim introduces health effects, and focuses on the longer term. Risk assessment studies often ignore within-city spatial variations of air pollutants. In Grenoble and Lyon areas (0.4 and 1.2 million inhabitants, respectively) in 2012, PM2.5 exposure was estimated on a 10×10 m grid by coupling a dispersion model to fine-scale data on population density. Outcomes were mortality, lung cancer and term low birth weight incidences. The numbers of cases attributable to air pollution were estimated overall and stratifying areas according to the European Deprivation Index, a measure of social deprivation. Estimations were repeated assuming spatial homogeneity of air pollutants within city. The proportion of cases attributable to air pollution was in the 3-8% range for mortality and 9–43% range for term low birth weight. In Grenoble, 6.8% (95% CI: 3.1–10.1%) of incident lung cancer cases were attributable to air pollution. The impact was underestimated by 8 to 20% when background monitoring stations were used to assess exposure, compared to fine-scale dispersion modeling. Health impact was highest in neighborhoods with intermediate to higher social deprivation.Several countries across Europe have implemented air pollution regulation policies, or low emission zones, France being an exception. We estimated the health impact of air pollution under different scenarios of reduction of fine particulate matter concentrations. Scenarios targeting a reduction in the PM2.5 annual averages by 5% led to a 10% decrease of the health burden, while actions aiming at only reducing the exposure of the population exposed above the 90th percentile did not yield a significant reduction of the health burden (around 1%).In conclusion, we have shown that short-term measurements cannot be used to model ultrafine particles levels in urban areas; we were among the first to rely on a fine-scale exposure model for estimating the health impact of air pollution, and quantify its impact on term low birth weight. Our estimations showed that background air quality monitoring stations used classically in France for health impact assessment studies tend to underestimate exposure, compared to a spatially-resolved dispersion model. We have provided an estimate of the air pollution decrease required to obtain a significant reduction of the health impact of air pollutants in urban areas.

While there is considerable academic research on the intersection of comprehensive plans, finance policies, zoning policies and how these factors influence real estate developers' choice of what land to develop and what buildings to construct on that land, little is understood about whether these three variables promote or hinder real estate developers' choice of whether to build communities that promote healthy living. Using urban planning theory as the foundation, the purpose of this correlational study was to determine how real estate developers' decisions are made to support healthy New Urbanism development in the United States. Secondary data from the Urban Land Institute were used for this multiple regression study that explored the degree to which comprehensive plans, finance, and zoning policies predict the likelihood that real estate developers will build New Urbanism communities in the United States. Findings indicated that comprehensive plans, finance policies, and zoning policies had a statistically significant influence on real estate developers' decisions on the types of communities to build in the United States by 53.6%, 46.8%, and 71.6% respectively p < .05. The information presented in this study is important to urban planners/designers, health care professionals, and municipal officials because of the intra and interdisciplinary approach of the built environment as a nonmedical determinant of health. Cultivating public and private collaboration to develop public policy could affect social change by directly affect the alterations and improvements in the built environment health that either promote or impede healthy outcomes.

Chemical (gaseous) emissions from wastewater treatment plants (WWTP) are perceived as odour and can generate undesirable health reactions. These could affect the quality of life to those regularly albeit intermittently exposed, although regular exposure may result in tolerance and loss of recognition of the odour. Consequently, research is necessary to establish the role of Environmental Impact Assessment (EIA) in ensuring that facilities such as WWTP do not pose a threat to local communities, particularly in relation to housing developments for poor communities. The aim of this study was to investigate if the EIA regulations were effectively implemented before building of the Residential Development Proiect (RDP) houses at KwaMathukuza, in Newcastle South Africa. Furthermore, the study intended to determine the impact the (WWTP) has on the health of people who reside close to the site and to establish if the families staying close to the WWTP have any common ailments such as handicapped babies, early deaths within families. Findings would also indicate if RDP houses should be built in close proximity to such sites. Data was collected through a survey of 85 residents living within five kilometers and ten residing beyond five kilometers from the WWTP. The participants were selected randomly. Municipality employees who worked with the WWTP were also sampled together with healthcare givers. Data included information about health of the community, their perception of the gases released from the WWTP as well as EIA meetings and processes related to the construction of the RDP houses. The outcome of this study revealed that EIA regulations were not adequately implemented and that this residential site was unsuitable for the construction of RDP houses. It emerged that the residence regularly experience unpleasant odours released from the WWTP. These could be associated with ill-health of the residents as well as v degradation the environment in general. The study also found that the effect of the WWTP affects even those communities who reside beyond five kilometers from the WWTP. The researcher argues for more stringent mechanisms to ensure that EIA regulations are properly implemented to prevent adverse effects on the communities. / Environmental Sciences / M. Sc. (Environmental Management)

Purpose: The purpose of this study was to study the association between Silver Diamine Fluoride (SDF) and Oral Health-Related Quality of Life as assessed by “The Early Childhood Oral Health Impact Scale” questionnaire. Methods: Parents of healthy children (ASA I and II) ages 1-5 with early childhood caries with reversible pulpitis who had application of SDF filled out a questionnaire at baseline and again after one month. The questionnaire was designed to evaluate the child’s behavior, physical abilities, pain, temperament, and how well the child gets along with others. Results: Wilcoxon Signed Rank Test was used to determine if responses to various ECOHIS items and the total scores were different between the two time points. Conclusion: Children with dental caries who had application of SDF reported less dental pain, less eating problems, higher quality of sleep and overall higher quality of life at one-month follow up compared with the baseline.

INTRODUÇÃO: A vacina pneumocócica conjugada 10-valente (VPC10) foi introduzida no calendário de imunização infantil do Programa Nacional de Imunizações em 2010. Este estudo analisou as taxas de incidência de Meningite Pneumocócica (MP) no Brasil, por faixa etária e unidade da federação (UF); a distribuição espacial das taxas de incidência de MP em menores de cinco anos no Brasil, por UF, no período pré (2005-2009) e pós-vacinação (2011-2013); e associações com variáveis socioeconômicas e cobertura vacinal. Foram analisadas a distribuição espacial das taxas de incidência de MP em menores de cinco anos, por município do estado de São Paulo (SP), no período pré e pós-vacinação, e a existência de aglomerados espaciais e espaço-temporais. Através de estatística espacial, foram analisadas associações das taxas de incidência de MP, por microrregiões do estado, com variáveis socioeconômicas e cobertura vacinal. MÉTODOS: Estudo ecológico de base populacional, que utilizou dados do Sistema de Informação de Agravos de Notificação. Cobertura vacinal e o Índice de Desenvolvimento Humano (IDH) foram utilizados na análise do Brasil. Na análise de SP, as unidades ecológicas foram municípios e microrregiões, e a variável socioeconômica foi o Índice Paulista de Responsabilidade Social (IPRS) da Fundação Sistema Estadual de Análise de Dados. Foram construídos mapas temáticos para as taxas de incidência de MP em menores de cinco anos, nos períodos pré e pós vacinação, cobertura vacinal e IDH, por UF. Também foram construídos mapas temáticos das taxas de incidência de MP em menores de cinco anos, por microrregião de SP, nos períodos pré e pós-vacinação, cobertura vacinal e IPRS, utilizando o software QGis 2.6.1. Para SP, foi utilizada a técnica de varredura (software SatScan 9.2) para analisar aglomerados. O modelo Gaussiano latente Bayesiano com modelos inflados de zeros de Poisson, através da aproximação de Laplace aninhada e integrada (INLA), foi utilizado na análise espacial para avaliar associações entre taxa de incidência de MP, cobertura vacinal e variáveis socioeconômicas. RESULTADOS: De 2005 a 2013, foram notificados 10.769 casos de MP. Crianças menores de cinco anos foram as mais acometidas. No período pós-vacinação (2011-2013), a taxa de incidência de MP diminuiu nos menores de cinco anos, especialmente nos menores de um ano (de 10,42/100.000, em 2005, para 4,13/100.000, em 2013). No Brasil, maiores taxas de incidência de MP ocorreram nos estados com maior IDH. Em SP ocorreu o mesmo, sendo encontrados, no período pré-vacinação, dois aglomerados de municípios - um de baixo risco para MP, no noroeste do estado (RR, 0,45, p=0,00025), e outro de alto risco no sudeste, englobando a capital do estado, (RR, 1,62, p=0,0000051). No período pós-vacinação, apenas um aglomerado de maior risco se manteve na mesma região (RR, 1,97, p=0,057). Na análise Bayesiana, riqueza foi identificada como fator de risco para MP (RR, 1,026, IC: 1,002-1,052) no período pré-vacinação. Cobertura vacinal, longevidade e escolaridade não foram significativas. CONCLUSÕES: Maior IDH e maior riqueza foram fatores de risco para MP, sugerindo necessidade de maior investimento na capacidade diagnóstica de MP nas áreas estudadas, avanços na qualificação da vigilância e notificação da doença / INTRODUCTION: The 10-Valent pneumococcal conjugate vaccine (PCV10) was introduced into the childhood immunization schedule of the Brazilian National Immunization Program in 2010. This study analyzed Pneumococcal Meningitis (PM) incidence rates in Brazil, by age group and federation unit (FU), the spatial distribution of PM incidence rates in under-5 children in Brazil, by FU, in the pre (2005-2009) and post-vaccination (2011-2013) periods, and associations with socioeconomic variables and vaccination coverage. We conducted spatial analysis of PM incidence rates in under-5 children, by municipality in SP, in pre and post-vaccination periods, and evaluated the existence of spatial and spatial-temporal clusters. Spatial statistics was used to test associations of PM incidence rates with socioeconomic variables and vaccine coverage, by state micro regions. METHODS: This is a population-based ecological study using data from the Sistema de Informação de Agravos de Notificação. Vaccine coverage and the Human Development Index (HDI) were used in the Brazilian analysis. In SP analysis, the ecological units were municipalities and micro regions, and the socio-economic variable was the Índice Paulista de Responsabilidade Social (IPRS) of the Fundação Sistema Estadual de Análise de Dados. Thematic maps were built for PM incidence rates in under-5 children, in the pre- and post-vaccination periods, vaccine coverage and HDI, by FU. Thematic maps were also built for PM incidence rates in under-5 children by SP micro regions, in the pre- and post-vaccination periods, vaccination coverage and IPRS using QGis 2.6.1 software. The scanning technique (SatScan 9.2 software) was used to analyze spatial and spatiotemporal clusters in SP. A Bayesian latent Gaussian model with zero-inflated Poisson model through the integrated nested Laplace approximation (INLA) was used in the spatial analysis to evaluate associations of PM incidence rates with vaccine coverage and socioeconomic variables. RESULTS: From 2005 to 2013, 10,769 PM cases were reported. Under-5 children were the most affected in the whole period. In the post-vaccination period (2011-2013), PM incidence rates decreased among under-5 children, especially among infants (from 10.42/100,000, in 2005, to 4.13/100,000, in 2013). Higher PM incidence rates occurred in states with higher HDI. The same occurred in SP, where two municipalities clusters were found in the pre-vaccination period - one of low risk for PM in the northwest of the state (OR, 0.45, p=0.00025), and another of high risk in the southeast, including the state capital (OR, 1.62, p=0.0000051). In the post-vaccination period, only one cluster of higher risk remained in the same area (RR, 1.97, p=0.057). In Bayesian analysis, wealth was identified as a risk factor for PM (RR, 1.026, CI: 1.002-1.052). Vaccination coverage, longevity and education were not important. CONCLUSIONS: A higher HDI as well as greater wealth were risk factors for PM. This result highlights the need to improve the diagnostic capacity of PM in studied areas, advancing in the surveillance quality and disease notification