This thesis focuses on health among children in the medieval town Old Lödöse (1100-1500 AD) in western Sweden. Through the study of health indicators (enamel hypoplasia, growth retardation and porotic hyperostosis) on adults (45 crania), children (31 complete individuals) and the commingled remains of children from severeal contexts. The results showed 66,7% (N= 30 of 45) of the adults and 67,7% (N= 21 of 31) of the children had presence of stress indicators. Although 61,5% (N=8 of 13) of the children and 37,5% (N=15 of 40) of the adults had presence of cribra orbitalia it manifested mildly on several of the individuals. Enamel hypoplasia was present on 53,8% (N= 7 of 13) of the children and 36,8% (N= 15 av 38) of the adults. The enamel disturbances occurred by the ages of two to five. Growth retardation was minimal and was within the standard deviation for each method. The population suffered from ill health due to varying degrees as a result of the urban environment, parasites and infections. Several of the individuals have experienced periods of stress during childhood. The population sample was compared to material from Skara (1100-1500 AD) and New Lödöse (1473-1624 AD). The comparison showed that there was similar health parameters in all three cities during the Middle Ages. / Syftet med denna studie var att undersöka hälsa respektive ohälsa hos barn i medeltida Gamla Lödöse (1100-1500 e.Kr.) genom att studera frekvensen av stressmarkörer. Materialet bestod av 45 kranier från vuxna individer (både män och kvinnor), 31 individer under 20 år samt  209 enskilda element från omrörda kontexter (barn). MNI för barnen i studien blev totalt 56. De stressmarkörer som studerades var emaljhypoplasier, porotic hyperostosis (cribra orbitalia, cribra cranii, cribra humeralis och cribra femoralis) och tillväxtstörningar. Hos vuxna individer studerades endast cribra orbitalia, cribra cranii och emaljhypoplaiser. Resultatet visade att 66,7% (N= 30 av 45) av de vuxna individerna uppvisade spår av stressmarkörer medan 67,7% (N=21 av 31) av barnen (endast de kompletta individerna) uppvisade spår av stressmarkörer. Cribra orbitalia uppvisades hos 61,5% (N= 8 av 13) av barnen medan hos de vuxna individerna var frekvensen endast 37,5% (N= 15 av 40). Nästintill alla individer hade mild grad av cribra orbitalia, likaså för cribra cranii. Emaljhypoplasier fanns hos 53,8% (N= 7 av 13) av barnen medan hos de vuxna var frekvensen 36,8% (N= 14 av 38). Emaljhypoplasierna uppstod i åldern två till tre hos barnen och åldern tre till fem år för de vuxna individerna. Tillväxtstörningarna hos barnen var minimala och inom standardavvikelserna för respektive metod. Slutsatsen var att den undersökta population led av ohälsa i varierande grad från ung ålder och att flera har upplevt episoder av stress orsakade av bland annat miljömässiga faktorer som ökade risken för infektionssjukdomar och parasiter. I jämförelser med material från Skara (1100-1500 e.Kr.) och Nya Lödöse (1473-1624 e.Kr.) framkom det att frekvensen av stressmarkörer är högre, men att antalet undersökta individer är mindre i Gamla Lödöse. Förutom det tros städerna ha varit lika gällande hälsoparametrar hos barn.

Thesis (Ph. D.)--State University of New York at Binghamton, Department of Anthropology, 2009. / Includes bibliographical references.

No description available.

No / Osteosarcoma is a rare type of malignant neoplasm that is most frequent in adolescents and young adults although it can develop at any age. It can metastasize from a primary site in bone to other bones and soft tissues. Usually the disorder causes a single bone-forming lesion (unicentric) but some cases have multicentric, bone-forming lesions. Some of these lesions develop at different sites at different times. In a second variant of multicentric osteosarcoma, synchronous bone-forming lesions develop at multiple sites. Distinguishing between these two types of multicentric osteosarcoma is challenging in a clinical context and the criteria for doing so are unlikely to be met in an archaeological burial. Wolverhampton burial HB 39 was excavated from an early-nineteenth century cemetery site in England. It consists of the incomplete skeleton of an adult male of at least 45 years of age with multicentric osteosarcoma. The individual represented by this burial also had diffuse idiopathic skeletal hyperostosis (DISH). Three of the bone-forming lesions associated with osteosarcoma developed on the bony outgrowths related to DISH.

Thesis (M. Sc. (Physiology)) --University of Limpopo, 2019 / Introduction: There is an increased trend in the prevalence of hypertension in children and adolescents in African countries. There are complications in diagnosing hypertension in children and adolescents due to the variation of blood pressure (BP) values with age, gender and height. The progression of the health transition with non-communicable diseases (NCDs) adds significantly to the disease burden, despite infectious diseases and undernutrition remaining persistent in both low and middle-income countries. Metabolic syndrome (MetS) is a global problem associated with the clustering of several cardiovascular risk factors. South African evidence suggests an upsurge of NCDs amidst the existence of communicable diseases (CDs) such as HIV/AIDS and tuberculosis. Moreover, NCDs and CDs in the country are influenced by socio-demographic factors; and thus tend to be more prominent in certain segments of the population. Aim and Objectives: The aim of this study was to perform blood pressure to height ratio and to determine lifestyle risk factors associated with metabolic syndrome among the Ellisras rural population aged 6-30 years, who are part of the ELS. Methods and materials: The current study is based on secondary data analysis of the Ellisras Longitudinal Study (ELS) and was conducted in two phases. Phase 1 included data analysis of all the participants in the ELS. This sample included a total number of 9002 children and adolescents (4678 boys and 4324 girls), aged 6-17 years. Parents or guardians provided written informed consent. Phase 2 consisted of biochemical analysis from a subsample of participants in the ELS. The subsample included 624 participants (306 males and 318 females) aged 18-30 years at the time the study was conducted. All participants underwent a series of anthropometric measurements (waist circumference and height) according to the standard of the International Society for the Advancement of Kinanthropometry (ISAK). The waist circumference (WC) measurements were taken to the nearest 0.1 cm, using a soft measuring tape. Metabolic syndrome was defined according to the International Diabetes Federation (IDF) criteria. Metabolic syndrome risk factors included total cholesterol (TCHOL), triglycerides (TG), high-density lipoprotein cholesterol (HDLC), elevated fasting blood glucose (FBG), elevated blood pressure (BP) and high waist circumference (WC). A dietary intake questionnaire was also administered to each participant and self‑administered questionnaire was used to collect data on lifestyle factors, including smoking and alcohol intake. Dietary intake variables used in the linear regression method were log transformed prior to analysis because of their skewed distribution. Receiver-operating characteristic (ROC) curve was used to assess the accuracy of BPHR to screen children with prehypertension and hypertension. The optimal systolic BPHR (SBPHR) and diastolic BPHR (DBPHR) cut-off points for hypertension were determined. Sensitivity/specificity, positive predictive values and negative predictive values were calculated. Results: The optimal thresholds for defining prehypertension was 0.77 in children aged 6-10 years and 0.73 in adolescents aged between 11 and 17 years for systolic BPHR and 0.55 in children and 0.53 in adolescents for diastolic BPHR, respectively. The corresponding values for hypertension stage 1 were 0.76 and 0.73 for SBPHR and 0.50 and 0.58 for DBPHR, respectively. The BPHR is an accurate tool for screening elevated BP in Ellisras children aged 6-17 years. This can help to prevent the misclassification of children and adolescent hypertension. Furthermore, this tool can be used to screen children before the development of prehypertension and hypertension. Moreover, it can be used to manage hypertension in Ellisras children, ultimately reducing the risks of developing hypertension and associated cardiovascular disease in adulthood. Overall, the prevalence of metS was 23.1% (8.6% males and 36.8% females). Females appeared to have higher mean values for WC, FBG, TCHOL and LDL-C than males (82.14, 5.62, 4.62 and 2.97, respectively). The only significant gender difference observed was on WC (p<0.001). Males on the other hand had higher mean values for HDL-C, TG, SBP and DBP than females (1.20, 1.06, 125.91 and 71.44, respectively). The only significant difference observed in this case was on SBP (p<0.001). No significant age group differences were observed in all the metabolic risk factors with the exception of DBP where the older (25-30 years) participants presented with high SBP than the younger age group (18-24 years) (70.96 mmHg vs 68.78 mmHg, p<0.05). While, majority of females had significantly high WC, elevated total cholesterol and LDL-C, and reduced HDL-C; majority of males had elevated BP, SBP and DBP. No significant age and gender differences were observed on dietary intake. However, according to the linear regression analysis, no association between log total energy, log added sugar, log SFA and log MUFA with metabolic risk factors. There was a low and negative significant association between log fibre with SBP and DBP (β:-0.004, p=0.003 and β:-0.004, p=0.046), respectively, crude. After adjusting for the potential confounding factors, log fibre was also associated with FBG (β:-0.028, p=0.046). Log PUFAs was inversely associated with FBG, HDL-C and SBP crude. Log trans fatty acids was inversely associated with WC, HDL-C and SBP crude. Both log PUFAs and log trans fatty acids were not associated with any metabolic risk factors after adjusting for potential cofounding factors. Log protein was inversely associated with SBP both crude and adjusted for potential cofounding factors. On predicting the actual risk using the logistic regression analysis, participants who had high dietary energy intake were significantly less likely to present with larger WC, low HDL-C and high LDL-C (OR: 0.250 95%CI [0.161;0.389], OR: 0.306 95%CI [0.220;0.425] and OR: 0.583 95%CI [0.418;0.812], respectively), but more likely to presents with elevated FBG, high TCHOL, high TG and hypertension (OR: 1.01 95%CI [0.735;1.386], OR: 1.039 95%CI [0.575;1.337], OR: 1.186 95%CI [0.695;2.023], OR: 5.205 95%CI [3.156;8.585], respectively) crude. After adjusting for age, gender, smoking and alcohol status, high energy intake was more likely to increase two times high the large WC and elevated FBG among study participants (OR: 2.766 95%CI [0.863;3.477] and OR: 2.227 95%CI [1.051;3.328], respectively). Furthermore, low dietary fibre intake was nearly four times more likely to increase the low HDL-C, crude (OR: 3.864 95%CI [1.067;13.988]) crude. Those participants who consumed high trans fats were more likely to present with high FBG (OR:1.424 95%CI [0.985;2.060]), but less likely to present with LDL-C (OR: 0.540 95%CI [0.321;0.906]) crude. However, after adding potential cofounding factors, participants with high fatty acid were less likely to present with high FBG (OR: 0.672 95%CI [0.441;1.023]). Conclusions: MetS is prevalent in young adults in Ellisras and is differentiated by age and gender with more females at an increased rate by virtue of their body size status, reduced HDL-C, elevated FBG and high LDL-C and the diet they consume that is in most cases high energy, more carbohydrates, high added sugar and SFA. Therefore, identifying groups that are at an increased risk and those that are in their early stages of MetS will help improve and prevent the increase of the metS in the future. These results have high policy implications. KEY CONCEPTS Metabolic syndrome; risk factors; blood pressure; blood pressure to height ratio; cardiovascular disease; dietary intake; rural South African.

Bab edh-Dhra is the most extensively excavated cemetery from Early Bronze Age, Jordan. Despite thorough study, the social structure and existence of social inequality remain unclear. This was addressed using osteological evidence of physiological stress to compare between family tombs. In societies exhibiting social inequality, individuals of lower status experience higher levels of stress. Evidence of physiological stress (femoral length, LEH, metabolic disorders, periosteal reactions, cribra orbitalia, and porotic hyperostosis) was recorded using standard methods for 250 adults. The artifact counts in this study have been previously published. Differences in the frequency of stress indicators were compared using chi-square tests. The results show no difference in the frequency of stress indicators between tombs and no correlation between artifacts and frequency of stress indicators. This indicates that families at Bab edh-Dhra experienced similar stress levels and low inequality. This may be due to cultural practices, subsistence methods or lack of data.

Diffuse idiopathic skeletal hyperostosis (DISH) is a spondyloarthropathy traditionally defined as having spinal and extra-spinal manifestations. However its diagnostic criteria only allow the identification of advanced DISH and there is little consensus regarding the extra-spinal enthesopathies. In this project, individuals with DISH from the WM Bass Donated Skeletal Collection were analysed to investigate the pathogenesis of DISH and archaeological English and Catalan samples (3rd–18th century AD) were studied to investigate how diet might have influenced the development of DISH. From the individuals from the Bass Collection, isolated vertical lesions representing the early stages of DISH (‘early DISH’) were identified. Both sample sets showed that the presence of extra-spinal manifestations varies significantly between individuals and that discarthrosis and DISH can co-exist in the same individual. In all archaeological samples, the prevalence of DISH was significantly higher in males and older individuals showed a higher prevalence of DISH. In both regions, the prevalence of DISH was the lowest in the Roman samples, the highest in the early medieval ones and intermediate in the late medieval samples. While when using documentary resources and archaeological data, it was hypothesised that the prevalence of DISH in the English and Catalan samples might have been different, the results show no significant differences even if English samples tend to show higher prevalence of DISH than the Catalan samples. This possibly suggests that the development of DISH depends on a combination of dietary habits and, possibly, genetic predisposition might influence the development of DISH. The individuals from the Bass Collection showed high prevalence of metabolic and cardiovascular conditions. In contrast, no association was found between DISH and rich-diet associated conditions (e.g. carious lesions and gout) or deficiency-related conditions (e.g. scurvy, healed rickets). / Institute of Life Sciences Research from the University of Bradford

Fibroblast growth factor-23 (FGF23) is a novel, bone-produced hormone that regulates renal phosphate (Pi) reabsorption and calcitriol metabolism. Disorders of mineral and bone metabolism, such as autosomal dominant hypophosphatemic rickets (ADHR) and hyperostosis-hyperphosphatemia syndrome (HHS), witness the importance of well-balanced serum levels of FGF23. Patients with chronic kidney disease (CKD) are highly morbid due to Pi retention/hyperphosphatemia and calcitriol deficiency, which lead to elevated serum levels of parathyroid hormone (PTH) and secondary hyperparathyroidism (sHPT). As a response to hyperphosphatemia, CKD patients have also remarkably high serum FGF23 levels, which are associated with cardiovascular risk factors and increased mortality in CKD. The overall aim of this dissertation was to discern a possible role of FGF23 in parathyroid biology. Our in vitro experiments on isolated bovine parathyroid cells demonstrate that FGF23 directly and dose-dependently suppresses the PTH production and secretion, while increasing the expression of the 25-hydroxyvitamin D3-activating enzyme 1α-hydroxylase. We investigated possible expressional changes in the FGF23 receptor co-factor Klotho in hyperparathyroid disorders and found that Klotho expression is decreased or absent and inversely correlated to serum calcium (Ca) in adenomas of primary HPT (pHPT). In the hyperplastic parathyroid glands of sHPT, Klotho expression declines in parallel with the kidney function and correlates with the glomerular filtration rate. Moreover, Klotho expression is suppressed by Ca and FGF23, increased by calcitriol, but unaffected by Pi and PTH in vitro. Finally, we identified a novel missense mutation in the gene encoding GALNT3, which is normally involved in the post-translational glycosylation of FGF23, as the cause of aberrant FGF23 processing in a patient with HHS. In summary, we provide evidence for a novel bone/parathyroid axis in which FGF23 functions as a direct, negative regulator of the PTH production. High extracellular Ca is a major determinant of the Klotho expression in pHPT, whereas the Klotho levels in sHPT may be attributed to a combination of the high FGF23 and Ca, and low calcitriol levels associated with CKD. Hence, the decreased Klotho expression in sHPT could explain the concomitantly high FGF23 and PTH levels, as well as the failure of FGF23 to prevent or mitigate the development of sHPT in CKD.

No description available.

Die Homöostase des Knochengewebes wird durch das balancierte Zusammenspiel von Ossifikation und Resorption gewährleistet. Eine in Relation zur Resorption zu starke Ossifikation führt zur Modellierungsstörung, Hyperostose und Sklerose. Knochenerkrankungen mit diesen Merkmalen werden als Sklerosierende Skelettdysplasien erfasst. Gegenstand der vorliegenden Arbeit sind fünf Skelettdysplasien aus dem Formenkreis der Sklerosierenden Skelettdysplasien: (1) Craniometaphysäre Dysplasie, autosomal dominante Form (MIM #123000); (2) Metaphysäre Dysplasie, Typ Braun-Tinschert (MIM *605946); (3) Caffey-Syndrom (MIM *114000); (4) McCune-Albright-Syndrom (MIM #174800); (5) Melorheostose (MIM 155950). Diese werden auf unterschiedlichen pathogenetischen Ebenen charakterisiert, die den Etappen des Weges entsprechen, der mit der Analyse des Phänotyps beginnt und zu einer Aufklärung des Basisdefektes führt. Die Arbeit gliedert sich ein in die Reihe von Bemühungen, zum molekularen Verständnis von Erkrankungen des Skelettsystems beizutragen. / Homeostasis of bone tissue is maintained by the balanced process of bone formation and resorption. Increased ossification in relation to resorption gives rise to conditions with modelling defects, hyperostosis and sclerosis. Skeletal diseases with these signs are classified as sclerosing bone dysplasias. The work presented here focuses on five skeletal dysplasias from the group of sclerosing bone dysplasias: (1) Craniometaphyseal dysplasia, autosomal dominant form (MIM #123000); (2) Metaphyseal dysplasia, Braun-Tinschert type (MIM *605946); (3) Caffey syndrome (MIM *114000); (4) McCune-Albright syndrome (MIM #174800); (5) Melorheostosis (MIM 155950). They were investigated at different pathogenetic levels that represent different steps on the path from phenotypic characterisation to clarification of the respective basic molecular defect. This work has contributed to our understanding of the molecular basis of skeletal diseases.