Made available in DSpace on 2016-04-28T14:59:45Z (GMT). No. of bitstreams: 1 2008 - Jamil Monte Braz.pdf: 328071 bytes, checksum: 176c3f850beea04e09748a13beaf240f (MD5) Previous issue date: 2008-04-10 / The present work was conducted in the Swine Experimental Unity of the UFRRJ Animal Science Institute, from august to november, 2005, to evaluate different levels of barley bagasse included in diets for swines in growing phase, from 35 to 60 kg of live weight. It was used 20 crossbreed gilts, with 35 kg on average of live weight, in a randomized blocks experimental design with five treatments, and four blocks. The five levels of barley bagasse inclusion were 0, 12.5, 25, 37.5 and 50%, replacing the ration based on the dry matter of the reference ration (0% of inclusion). The performance variables ration intake (RI), barley bagasse intake (BBI), total feed intake (TFI), daily ration intake (DRI), daily barley bagasse intake (DBBI), daily feed intake (DFI), total body weight gain (TWG), daily body weight gain (DWG) and feed conversion (FC), also carcass characteristics and weights of organs and visceras were submitted to variance and polynomial regression analysis. It was observed linear reduction on RI and quadratic effect on all the other performance parameters evaluated. The BBI increased with the BB increasing level while TFI increased until 14.91% then decreasing after this level of inclusion. A quadratic effect was observed on DRI and DBBI while DFI increased until the level of 15.00% then decreasing after this level of inclusion. TWG and DWG increased until levels of 12.89 and 14.00% respectively, then decreasing after this level of inclusion. The FC improved progressively until 13.34% of inclusion then getting worse after this level of inclusion. Were evaluated: hot carcass weight (HCW), cold carcass weight (CCW), carcass length (CL) and carcass yields (CY), backfat thickness (BT), ham weight (HW) and ham yield (HY), palette weight (PW) and palette yield (PY), lomb weight (LW) and lomb yield (LY), and loin eye area (LEA). It was observed a quadratic effect on HCW and a linear reduction effect on PW and PY, as the level of barley bagasse inclusion was increased in the swines diets, with none influence on the other carcass characteristics. The Weights of gastro-intestinal tracts (GIT), viscera (VISC), stomach (SW) and liver (LW) were evaluated. There was not any influence on the weights of these last variables due to the level of BB in the growing phase diet. It was observed linear reduction in the feeding cost (FCT) and quadratic effect in the cost per unit of gain (CPUG), which decreased until 22.72% and increasing after this level of BB inclusion. The best level of BB inclusion in diets for swines in growing phase would be 14.91% for higher total DM intake, 12.89% for higher bodyweight gain and 13.34% for the best feed conversion. BB can be included in the growing diet up to 17,36%, without compromising the carcass quality of swines slaughtered at 100 kg of liveweight. BB can be included up to 22.72% in diets of swines in growing phase for reduction of the feeding costs. / O presente trabalho foi realizado no Setor de Suinocultura do Instituto de Zootecnia da Universidade Federal Rural do Rio de Janeiro (FAIZ/UFRRJ), durante o per?odo de agosto a novembro de 2005, com o objetivo de avaliar diferentes n?veis de inclus?o de baga?o de cevada na dieta de su?nos em fase de crescimento, dos 35 aos 60 kg de peso vivo. Foram utilizados 20 animais mesti?os das ra?as Large White, Duroc e Landrace, f?meas com peso m?dio de 35 kg, distribu?dos em delineamento de blocos ao acaso com cinco tratamentos e quatro blocos. Os cinco n?veis de inclus?o de baga?o de cevada na dieta foram: 0%; 12,5%; 25%; 37,5% e 50%, substituindo a ra??o com base na mat?ria seca da ra??o refer?ncia (0% de inclus?o). Os par?metros de desempenho consumo de ra??o (CR), consumo de baga?o de cevada (CBC), consumo total (CT), consumo di?rio de ra??o (CDR), consumo di?rio de baga?o de cevada (CDBC), consumo di?rio (CD), ganho de peso total (GP), ganho de peso di?rio (GPD) e convers?o alimentar (CA), assim como caracter?sticas de carca?a e pesos dos ?rg?os e das v?sceras foram submetidos ? an?lise de vari?ncia e de regress?o. Observou-se redu??o linear no CR, e efeito quadr?tico sobre os demais par?metros de desempenho estudados. Observou-se efeito quadr?tico sobre o CBC com o aumento do n?vel de inclus?o, enquanto o CT aumentou at? o n?vel de 14,91% e reduziu ap?s esse n?vel de inclus?o. Observou-se efeito quadr?tico no CDR e no CDBC enquanto o CD aumentou at? o n?vel de 15,00% passando a diminuir ap?s esse n?vel de inclus?o. O GP e o GPD aumentaram at? o n?vel de 12,89 e 14,00% respectivamente, apresentando redu??o ap?s esse n?vel de inclus?o. A CA melhorou gradativamente com a inclus?o at? o n?vel de 13,34% passando a piorar ap?s esse n?vel de inclus?o. Foram avaliados: peso de carca?a quente (PCQ), peso de carca?a resfriada (PCR), comprimento de carca?a (CC) e rendimento de carca?a (RC), espessura de toucinho (ET), peso de pernil (PP) e rendimento de pernil (RP), peso de paleta (PPL) e rendimento de paleta (RPPL), peso de lombo (PL) e rendimento de lombo (RL), e ?rea de olho de lombo (AOL). Observou-se efeito quadr?tico no PCQ e efeito linear no PPL e no RPPL, ? medida que se aumentou o n?vel de baga?o de cevada na dieta dos su?nos, n?o tendo sido observado influ?ncia sobre os demais par?metros de carca?a. Foram avaliados os pesos de trato gastro-intestinal (TGI), das v?sceras (VISC), de est?mago (EST) e de f?gado (FIG). N?o houve influ?ncia do n?vel de baga?o de cevada na dieta dos su?nos em crescimento sobre esses par?metros. Observou-se redu??o linear no custo de alimenta??o (CAL) e efeito quadr?tico no custo por unidade de ganho (CPUG), observando-se redu??o em at? 22,72% no CPUG e aumento ap?s esse n?vel. O melhor n?vel de inclus?o de baga?o de cevada em dietas para su?nos em crescimento seria de 14,91%, para maior consumo total de MS, 12,89% para m?ximo ganho de peso e 13,34% para a melhor CA. O baga?o de cevada pode ser inclu?do na dieta de su?nos em fase de crescimento em n?veis de at? 17,36%, sem comprometer a qualidade de carca?a de su?nos abatidos aos 100 kg de peso vivo. O baga?o de cevada pode ser inclu?do na dieta de su?nos em fase de crescimento em n?veis de at? 22,72% para redu??o dos custos de alimenta??o.

<p>During the past two decades research has shown that brands are among a company’s most valuable assets. However, in today’s competitive landscape, it is not enough to just create strong brands. The focus lies rather in managing a range of brand lever-age strategies within complex brand portfolios. Moreover, the majority of today’s established brand concepts do not represent the reality of contemporary brand man-agement. Instead, they tend to be based on dichotomies and simplifications. In addi-tion, there is a lack of criticism towards many of the established brand concepts resulting in the reduction of brand management to a number of static categories and stagnated definitions – thereby missing out on the analysis of important intersec-tional issues between the various categories. This book explores the somewhat for-gotten area of intersection, investigating the territory in-between brands.</p><p>The methods used consist of a literature review covering some of the most influ-ential brand models within the area of brand portfolio and brand leverage as well as an empirical case study including the following seven brands: Adidas, Bang & Oluf-sen, Electrolux, H&M, Microsoft, Peak Performance and W. L. Gore & Associates.</p><p>The findings show that conventional brand management models and terminology do not fully explain common marketplace strategies and practice. As a result, this research introduces a more realistic viewpoint and dynamic framework that is based on convergence and that allows migration and iteration rather than today’s static approach. The framework, named the brand leverage palette, introduces various nuances between different leverage strategies, both adding clarity and offering guid-ance by explaining different migration movements among today’s brand portfolios.</p>

During the past two decades research has shown that brands are among a company’s most valuable assets. However, in today’s competitive landscape, it is not enough to just create strong brands. The focus lies rather in managing a range of brand lever-age strategies within complex brand portfolios. Moreover, the majority of today’s established brand concepts do not represent the reality of contemporary brand man-agement. Instead, they tend to be based on dichotomies and simplifications. In addi-tion, there is a lack of criticism towards many of the established brand concepts resulting in the reduction of brand management to a number of static categories and stagnated definitions – thereby missing out on the analysis of important intersec-tional issues between the various categories. This book explores the somewhat for-gotten area of intersection, investigating the territory in-between brands. The methods used consist of a literature review covering some of the most influ-ential brand models within the area of brand portfolio and brand leverage as well as an empirical case study including the following seven brands: Adidas, Bang &amp; Oluf-sen, Electrolux, H&amp;M, Microsoft, Peak Performance and W. L. Gore &amp; Associates. The findings show that conventional brand management models and terminology do not fully explain common marketplace strategies and practice. As a result, this research introduces a more realistic viewpoint and dynamic framework that is based on convergence and that allows migration and iteration rather than today’s static approach. The framework, named the brand leverage palette, introduces various nuances between different leverage strategies, both adding clarity and offering guid-ance by explaining different migration movements among today’s brand portfolios.

As organisations try to emerge from the recent economic downturn, they attempt to enter different markets to decrease their dependency on their core market. Due to high costs in R&amp;D and the risk of failure, organisations try to sell the core components of their products to business partners who can incorporate these components into their own offering. Using a qualitative research method, we studied the case of TACHI as a player in the construction equipment industry. The purpose of the research was to find factors for maintaining successful business partnerships within this industry and also the role of co- branding in these business partnerships. After analysing the results of our study and reflecting on the theoretical framework, we concluded that operational compatibility, and commitment and trust were considered as the key factors that were most important in making business partnerships work successfully. Interestingly, players in the construction equipment industry do not consider co-branding as a strategy for entering new markets. However, we discovered a new phenomenon, which is informal branding, and we recommend this as a topic for future research.

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior / The aim of this study was to evaluate the effect of cadusafos and Fluensulfone nematicides applied at three different depths and positions in the soybean planting in furrow, in order to control Meloidogyne javanica, Pratylenchus brachyurus end Heterodera glycines. The experiments were cared out in the field naturally infested by nematodes, Júlio de Castilhos city - RS. It was nine treatments and five replications in a randomized block design, totaling 45 experimental units per experiment. The treatments were: 1 check treatment; 2 - position 1 (nozzle installed on the upper furrower); 3 - Position 2 (nozzle installed at the bottom of the open furrow); 4 - Position 3 (nozzle installed in the distribution disc of seeds); 5 - Positions 1 and 2 associates; 6 - The positions 2 and 3 associates; 7 - Positions 1 and 3 associates; 8 Full seed treatment by Avicta completo (abamectin (30 g ai.ha-1) + thiamethoxam (42 g ai.ha-1) + fludioxonil (1.5 g ai.ha-1) + metalaxyl-M (1.2 g ai.ha-1 ) + thiabendazole (9 g ai.ha-1) and 9 - position 1 and Avicta completo treatment seeds associated. The variables measured in the experiment were: number of nematodes in the soil, number of nematodes on the roots, shoot dry weight, plant height (pre-harvest); number of pods per plant and Yield. The results showed significant reduction in the population of nematodes in the both soil and the roots, regardless of the nematicide. For the deposition positions in soil, the responses were vary according to the species of nematodes in the soil. / O objetivo do presente trabalho foi avaliar o efeito dos nematicidas Fluensulfone e Cadusafós aplicados no sulco de semeadura da soja, em três diferentes profundidades no solo para o controle de Meloidogyne javanica, Pratylenchus brachyurus e Heterodera glycines. Os experimentos foram conduzidos a campo, no município de Júlio de Castilhos RS, em área comercial de soja naturalmente infestada. Os tratamentos foram dispostos no delineamento de blocos ao acaso, contendo nove tratamentos e cinco repetições, totalizando 45 unidades experimentais por experimentos. Os tratamentos foram: 1 - Testemunha sem produto; 2 - Posição 1 (Ponta instalada na parte superior do sulcador); 3 - Posição 2 (Ponta instalada na parte inferior do sulcador); 4 - Posição 3 (Ponta instalada na haste do disco de distribuição das sementes) 5 - As pontas 1 e 2 associadas; 6 - As pontas 2 e 3 associadas; 7 - As pontas 1 e 3 associadas; 8 - Tratamento de semente com Avicta completo (abamectina + tiametoxam + fludioxonil + metalaxil-M + tiabendazol - 30 + 42 + 1,5 + 1,2 + 9 g de i.a./ha) e 9 - A ponta 1 associada ao tratamento de semente com Avicta completo. As variáveis resposta medidas no experimento foram: número de nematoides presentes no solo, aos 30 dias após a emergência (D.A.E.); número de nematoides nas raízes (30 D.A.E.); massa seca de parte aérea (MSPA), aos 30 DAE; estatura de plantas (Pré-colheita); número de legumes por planta e produtividade. Os resultados mostraram que houve redução significativa na população dos nematoides, tanto no solo quanto nas raízes, independente do nematicida aplicado. No entanto, foram observadas diferentes respostas de controle em função dos pontos de deposição dos nematicidas no solo.

Made available in DSpace on 2015-08-19T13:52:55Z (GMT). No. of bitstreams: 2 13.pdf: 7121518 bytes, checksum: a7c8e7a7bd443ccd7df30b5090abf1e0 (MD5) license.txt: 1748 bytes, checksum: 8a4605be74aa9ea9d79846c1fba20a33 (MD5) Previous issue date: 2013 / Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos/Farmanguinhos. Rio de Janeiro, RJ, Brasil. / O presente estudo teve por objetivo investigar e avaliar a possível contribuição que a obrigatoriedade do registro de Insumos Farmacêuticos Ativos (IFAs), estabelecida pela Resolução da Diretoria Colegiada da ANVISA (RDC) n° 57/2009, a partir de 2010, teve no estabelecimento da isonomia regulatória entre o fabricante do IFA no Brasil e o fabricante internacional e que efetividade essa isonomia teve no restabelecimento da produção local de IFAs quando aliada à implementação de outras ações demandadas pela indústria farmoquímica brasileira, como a isonomia tributária, os incentivos fiscais, as parcerias para o desenvolvimento produtivo e o poder de compra do Estado. A pesquisa foi do tipo bibliográfica, documental e longitudinal. Constatou-se que, passados dois anos desde o início da exigência do registro de IFA, esta se mostrou efetiva na obtenção da isonomia regulatória. Porém, o tempo de análise não foi suficientemente longo para assegurar que a mesma, conjugada com outras ações do governo para o incentivo à produção local de IFAs, tenha sido capaz de promover o aumento, via substituição das importações desses produtos, apesar de haver sinalizações de que isso acontecerá. Como consequência espera-se que traga um aumento da produção do IFA e a redução da dependência do Brasil ao fornecimento externo, possibilitando o aumento da oferta interna desses insumos aos laboratórios farmacêuticos instalados no país, sejam eles públicos ou privados, além de melhorar a qualidade e o acesso dos medicamentos disponibilizados à sociedade brasileira. / The present study had as objectives to investigate and evaluate the possible contribution that the requirement of registration of Active Pharmaceutical Ingredients (APIs), established by the Resolução da Diretoria Colegiada of ANVISA Nr. 57/2009, as of 2010, had on the establishment of the regulatory isonomy between the producer of the API in Brazil and the international producer as well as the effectiveness this isonomy had in the reestablishment of the local production of APIs, when applied in parallel with the implementation of other actions demanded by the Brazilian pharmochemical industry, like the tax isonomy, the fiscal incentives, the partnerships for the productive development and the State buying power. The investigation involved bibliographic, documental and longitudinal analysis of the material available. It was concluded that, after two years since the beginning of the registration requirement, it turned out to be effective in bringing up the desired regulatory isonomy. However, the space of time used for the analysis was not sufficiently long to ensure that the registration, coupled with other governmental actions to promote the local production of APIs, could have been capable to promote the increase, via substitution of importations, of these products, although there are some signs that this will happen. As a consequence it is expected that it will bring an increase of the API production and the reduction of the Brazilian dependence of external supply, giving space to the internal offer of these products to the pharmaceutical laboratories located in Brazil, either public or private, besides improving the quality and the access of the medicines made available to the Brazilian society.

Made available in DSpace on 2014-06-11T19:31:11Z (GMT). No. of bitstreams: 0 Previous issue date: 2008-03-28Bitstream added on 2014-06-13T20:41:33Z : No. of bitstreams: 1 pontieri_cff_dr_jabo.pdf: 434346 bytes, checksum: 3659c2a974a779de37127ac0f26affc1 (MD5) / Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) / Os poucos estudos disponíveis na literatura indicam que os gatos têm uma alta capacidade digestiva de gorduras, mas que pode haver declínio desta função com o avançar da idade. Foram conduzidos dois experimentos, o primeiro teve como objetivo determinar na espécie a energia metabolizável (EM) e a digestibilidade da gordura e dos ácidos graxos do óleo de soja (OS), óleo de vísceras de frango (OVF) e sebo bovino (SB). Foram utilizados 60 gatos, divididos em dez dietas, uma dieta referência (DR) e nove dietas testes. As dietas testes eram a DR adicionadas de 5%, 10% ou 15% do ingrediente em estudo. O OS e o OVF apresentaram digestibilidade superiores ao SB, que também apresentou menor digestibiliade de ácidos graxos. Para os três ingredientes, os ácidos graxos poliinsaturados tiveram digestibilidade superior aos ácidos graxos monoinsaturados e saturados. Os ácidos graxos C20:2 e C20:4 tiveram digestibilidade de 100%. O OVF teve a maior EM (9088 kcal/kg), seguido do OS (8850 kcal/kg) e do SB (8032 kcal/kg). O segundo experimento estudou os efeitos da substituição de 3,5% ou 7% do extrato etéreo ácido de uma dieta por lecitina de soja sobre a digestibilidade de nutrientes e EM em um grupo de gatos adultos (AD) e outro de idosos (ID). O ID apresentou menores digestibilidade da matéria seca, matéria orgânica, proteína bruta e energia bruta, bem como menor EM das dietas. Não foi encontrado efeito de idade ou da adição de lecitina na digestibilidade do extrato etéreo ácido. O ID apresentou menor digestibilidade do C18:0 e maior dos C14:0 e C17:0. Os dois grupos apresentaram digestão aparente de 100% para os C20:4, C20:5, C22:3. A adição de lecitina de soja diminuiu a digestibilidade do C20:3n3 no grupo ID, mas não alterou a digestibilidade do AD. / There are few studies on fat digestibility by cats. These animals have a high ability of digesting fat, but fat digestibility might decline with age. This paper report two experiments, the first studied the metabolizable energy (ME) and digestibility of fat and fatty acids from soybean oil (SO), poultry fat (PF) and tallow (T). Sixty cats were used, distributed in 10 foods, one reference diet (RD) and 9 test diets. Test diets were composed by the addition of 5%, 10% or 15% of the ingredient in study to a RD. Results show that SO and PF have higher fat and fatty acids digestibilities than tallow. For all three ingredients polyunsaturated fatty acids showed higher digestibility than saturated and monounsaturated ones. The fatty acids C20:2 and C20:4 showed 100% digestibility. The PF showed the highest ME (9088 kcal/kg), followed by OS (8850 kcal/kg) and tallow (8032 kcal/kg). The second experiment analyzed the effects of the substitution of 3.5% and 7% of the diet’s acid hydrolyzed fat (AHF) for soybean lecithin on food digestibility and ME by adult and senior cats. The senior cats showed lower digestibility of dry matter, organic matter, crude protein and crude energy. They have also exhibited lower diet ME. AHF digestibility were similar between diets and ages, showing no effect of lecithin. The senior cats showed lower digestibility of C18:0 and higher digestibility of C14:0 and C17:0 than adult ones. Both groups showed an apparent digestibility of 100% for C20:4, C20:5, C22:3 fatty acids. The addition of lecithin reduced the digestibility of C20:3n3 to senior cats, but did not alter the digestibility for adult ones.

Made available in DSpace on 2014-06-11T19:28:22Z (GMT). No. of bitstreams: 0 Previous issue date: 2009-12-04Bitstream added on 2014-06-13T18:57:28Z : No. of bitstreams: 1 martins_ms_me_jabo.pdf: 1334577 bytes, checksum: 558ffb190a2980722ebcf5da43d4c243 (MD5) / Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) / O objetivo do presente estudo foi determinar por meio dos métodos de substituição, os coeficientes de digestibilidade aparente (CDA) das leveduras de cerveja e de cana-de-açúcar autolisada e íntegra, e de inclusão de teores crescentes das leveduras de cana-de-açúcar em dietas extrusadas para cães adultos. Dois ensaios foram conduzidos; no primeiro foi utilizado o método de substituição e 4 dietas experimentais, uma dieta referência isenta de levedura e outras três compostas pela substituição de 15% da dieta basal por leveduras de cerveja e de cana-de-açúcar autolisada e íntegra, respectivamente. Para o segundo ensaio foram utilizados 35 cães adultos distribuídos em 5 tratamentos e 7 repetições por dieta, estas sendo: 0 (basal), 7,5 e 15% de levedura de cana-de-açúcar autolisada e 7,5 e 15% de íntegra. No primeiro ensaio, os CDA da PB são 96,47, 62,98 e 74,70% e da EB 84,01, 68,43 e 75,95%, respectivos as leveduras; havendo diferença entre as leveduras avaliadas apenas para o CDA da PB (p<0,05). No segundo ensaio, os tratamentos não se mostraram diferentes quanto a digestibilidade para os nutrientes MS, MO, EEA, FDN e EB (p>0,05). As energias das dietas acima são respectivamente (Kcal/Kg MS): ED (4107,74; 3995,23, 3922,53; 4066,7; 3921,15) e EM (3714,96; 3749,46; 3667,53; 3876,23; 3673,16) e os CDA (%): MS (81,95; 82,13; 79,14; 80,79; 80,59), MO (86,56; 85,88; 83,68; 85,09; 85,07), PB (84,68; 85,20; 81,90; 83,31; 82,89), EEA (83,68; 83,58; 81,28; 83,82; 82,69), FB (44,99; 33,10; 30,14; 37,33; 22,37), FDN (47,40; 54,20; 45,36; 46,70, 50,99) e EB (86,03; 85,09; 82,54; 84,81; 84,13). A utilização da levedura de cana-de-açúcar não influenciou o CDA das dietas para MS, MO, PB, EEA, FDN, EB e EM das dietas (p<0,05), porém prejudicou linearmente, conforme aumento na inclusão das leveduras de cana-de-açúcar, o CDA da FB e ED (p>0,05). Conforme aumento na... / The present study aimed to determine, for dogs, the digestibility of the brewer’s yeast and sugar cane yeast, autolyzed and integral, and the diets’ nutrients that used the sugar cane yeast in increasing inclusions. Two metabolism assays were performed, the first one had used the substitution method to define the digestibility of the ingredients tests, being made one without yeast (control) and others 3 tests diets (15% brewer’s yeast, sugar cane autolyzed and integral + 85% control diet). In the second assay, it was used 35 adult dogs distributed in 5 treatments with 7 replications for each diet. These were: 0 (control), 7,5 and 15% sugar cane yeast autolyzed and 7.5 and 15% of integral yeast. In the first assay, the coefficients of apparent digestibility (CAD) of the CP were 96.47, 62.98 and 74.70%, and CE 84.01, 68.43 and 75.95%, respectively from yeasts; just the CP was different between the yeast evaluated (p<0,05). In the second assay, the treatments weren’t difference for the dry matter (DM), organic matter (OM), acid ether extract (AEE), neutral detergent fiber (NDF) and crude energy (CE) between the ingredients. The energies from diets were respectively (Kcal/Kg CM): digestible energy (DE) (4,107.74; 3,995.23; 3,922.53; 4,066.7; 3,921.15) and metabolizable energy (ME) (3,714.96; 3,749.46; 3,667.53; 3,876.23; 3,673.16) and the CAD (%): DM (81.95; 82.13; 79.14; 80.79; 80.59), OM (86.56; 85.88; 83.68; 85.09; 85.07), CP (84.68; 85.20; 81.90; 83.31; 82.89), AEE (83.68; 83.58; 81.28; 83.82; 82.69), crude fiber (CF) (44.99; 33.10; 30.14; 37.33; 22.37), NDF (47.40; 54.20; 45.36; 46.70, 50.99) and CE (86.03; 85.09; 82.54; 84.81; 84.13). The sugar cane yeast did not affect the diets’ CAD of DM, OM, AEE, NDF and ME of the diets (p<0.05); but, the CDA had a linear reduction in CP, CF, CE and DE (p>0.05) with the increasing inclusions. Therefore, the brewer’s yeast presented ... (Complete abstract click electronic access below)

Made available in DSpace on 2016-06-02T19:51:22Z (GMT). No. of bitstreams: 1 DissMMO.pdf: 1788461 bytes, checksum: c91e5052b5a23718a605943ed35a8163 (MD5) Previous issue date: 2006-08-09 / Universidade Federal de Minas Gerais / The capacity of introducing new products in the market has been considered as an important factor for companies competitiveness. This is the reality of the food industry that adopts technological and organizational changes in their productive processes, the materials supply and the products distribution, mainly for products differentiation. These changes evidence the suppliers and distributors growing to the food processed supply chain. Then, the importance of this study: its contribution for the understanding of the supplier s paper in the new beverage development process. Besides, the researched theme has relevance considering the shortage of works that analyze the relationship of ingredients suppliers in the food chain. It is had as presupposition, based on the literature, that the supplier involvement in the product development process propitiates time and cost reduction in the product development, quality improvement of the acquired materials and larger access facility and technology application. The analysis of the suppliers involvement in the supply chain focused in their participation in the buyer s new product development process, narrowing to the ingredients suppliers. This work was developed with multiple cases studies in four companies of the segments of no alcoholic drinks (fresh juice and powdered soft drinks) and drunk milky and a common ingredient supplier to those companies. Those segments were chosen due to the great growth of the demand by these products, given the appeal of their functional (health) and convenience (comfort). It was observed, mainly, that the responsibility degree of the supplier in the product development is function of its technical competence (knowledge and experience). It was also verified that the supplier s participation that happens in the initial phases of the new beverage process development, facilitates the access and technology application in the food product development process. / A capacidade de introduzir novos produtos no mercado tem sido considerada como importante fator de competitividade das empresas. Esta é a realidade da indústria de alimentos que adota mudanças tecnológicas e organizacionais em seus processos produtivos, no suprimento de seus materiais e na distribuição de seus produtos, principalmente para diferenciação de produtos. Estas mudanças evidenciam a crescente integração dos fornecedores (a montante) e de distribuidores (a jusante) à cadeia de suprimentos de processadoras de alimentos. Daí importância deste estudo: sua contribuição para a compreensão do papel do fornecedor no processo de desenvolvimento de novas bebidas. Além disso, o tema pesquisado tem relevância considerando a escassez de trabalhos que analisam a relação de fornecedores de ingredientes na cadeia de alimentos. Tem-se como pressuposto, baseado na literatura, que o envolvimento do fornecedor no processo de desenvolvimento de produto propicia redução de tempo e de custos no desenvolvimento de produtos, melhora da qualidade dos materiais adquiridos e maior facilidade de acesso e aplicação de tecnologia. A análise do envolvimento de fornecedores na cadeia de suprimento focou na sua participação no processo de desenvolvimento de novos produtos junto ao cliente industrial, restringindo-se aos fornecedores de ingredientes. Este trabalho foi desenvolvido com estudo de múltiplos casos em quatro empresas dos segmentos de bebidas não alcoólicas (sucos pronto para beber e refresco em pó) e bebidas lácteas e um fornecedor de ingrediente comum às empresas. Esses segmentos foram escolhidos devido ao grande crescimento da demanda por estes produtos, dado o apelo de serem funcionais (saúde) e de conveniência (comodidade). Observou-se, principalmente, que o grau de responsabilidade do fornecedor no desenvolvimento de produto é função de sua competência técnica (conhecimento e experiência). Constatou-se também que a participação do fornecedor que ocorre nas fases iniciais do processo de desenvolvimento de novas bebidas, facilita o acesso e aplicação de tecnologia no processo de desenvolvimento de produtos alimentícios.

A epilepsia é uma patologia que afeta 50 milhões de pessoas, sendo que cerca de 30% dos pacientes apresentam epilepsia refratária, ou seja, não respondem a terapia medicamentosa disponível. Portanto, é necessária a busca contínua de novos fármacos. Os complexos organometálicos vêm ao encontro a esta necessidade conjugando moléculas já aplicadas na terapia (como o ácido valproico), a metais essenciais e outros ligantes a fim de aprimorar os efeitos farmacológicos. Neste trabalho foram testados quatro complexos derivados do ácido valproico: [Cu(Valp)2Fen] , [Cu(Valp)2Bipi], [Zn(Valp)2Fen] e [Zn(Valp)2Bipi], através do screening toxicológico embrionário e atividade anticonvulsivante em zebrafish induzidos por pentilenotetrazol (PTZ). O complexo [Cu(Valp)2Bipi] apresentou maior toxicidade embrionária (CL50=0.12 μM), seguido pelo [Zn(Valp)2Bipi] (CL50 = 10μM). Estes mesmo complexos nas doses de 10 mM/Kg, 30 mM/Kg e 100 mM/Kg para derivado contendo zinco a intensidade das convulsões em relação ao valproato de sódio (175 mM/Kg) em peixes adultos, demonstrando ação superior ao fármaco tradicional. Devido a baixa toxicidade aliada a ação anticonvulsivante evidente selecionamos o derivado [Zn(Valp)2Bipi] para estudos futuros em modelos complexos de epilepsia. / Submitted by Ana Guimarães Pereira (agpereir@ucs.br) on 2016-04-29T13:43:16Z No. of bitstreams: 1 Dissertacao Lauren Dockhorn Grunspan.pdf: 2281256 bytes, checksum: 5ed8d708e6f55d2418086df48fc4f6ac (MD5) / Made available in DSpace on 2016-04-29T13:43:16Z (GMT). No. of bitstreams: 1 Dissertacao Lauren Dockhorn Grunspan.pdf: 2281256 bytes, checksum: 5ed8d708e6f55d2418086df48fc4f6ac (MD5) Previous issue date: 2016-04-27 / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, CAPES / The most important determinant of quality of life in patients with epilepsy is complete seizure control, and therefore this should be the ultimate goal of pharmacological therapy. Unfortunately, around 30% of epileptic patients still suffer with refractory epilepsy. Metal ions have been frequently incorporated into pharmaceuticals for therapeutic or diagnostic purposes and the research. In this study, we access the embryo toxicity and anticonvulsant activity of 4 novel metallodrugs, with Zn+2 and Cu+2, derivative with valproic acid and the N-donor ligand in adult zebrafish pentylenetetrazole epileptic seizure model. [Cu(Valp)2Bipy] LC50 in 48 Hours Post Fertilization (hpf) was 0.22 μM and 0.12 μM in 96 hpf followed by [Zn(Valp)2Bipy] (LC50 = 10 μM). This same metallodrugs ([CuValp)2Bipi] 10 mM/Kg and [Zn(Valp)2Bipi] 30 mM and 100 mM/Kg) displayed a superior activity reducing the seizure intensity compared to Sodium Valproate (175 mM/Kg). As conclusion, among all, the [Cu(Valp)2Bipi] showed the best anticonvulsant effects, but due to its toxic effects on embryos and larvae, the [Zn(Valp)2Bipi] should be considered the most promising for future studies as anticonvulsant drug.