[pt] A presente pesquisa se propõe a investigar o modo como o problema do Mal é abordado em grande parte do chamado Catolicismo Midiático brasileiro. Este conceito abarca as expressões do movimento carismático que, nas últimas décadas, começaram a se utilizar dos meios de comunicação para ampliar o raio de alcance da sua ação evangelizadora. A partir desse alcance, essa vertente do catolicismo brasileiro oferece consolo e uma proposta de Salvação diante dos males experimentados por milhões de brasileiros e de brasileiras. Além disso, tendo presente a atual conjuntura eclesial, a pesquisa leva em conta o momento novo vivido pela Igreja Católica com o pontificado do Papa Francisco. Este deseja fomentar uma reforma da Igreja em chave missionária, a fim de que a instituição eclesiástica redescubra, como sua função primordial, o anúncio e o testemunho da Salvação integral em Jesus Cristo. Sendo assim, após uma análise históricosociológica do processo de modernização do campo religioso brasileiro (o que permitiu o surgimento do Catolicismo Midiático), bem como dos textos selecionados produzidos por essa religiosidade e que são objeto da pesquisa, o estudo pretendeu também analisar criticamente o material coletado à luz da teologia do Papa. O objetivo é investigar as contribuições e contradições do Catolicismo Midiático para a proposta de Salvação anunciada pelo Papa Francisco, além de apresentar alternativas que permitam uma maior colaboração com o seu pontificado. / [en] This research focus on investigating the way that the problem of Evil is conducted in the largest part of what is called Brazilian Media Catholicism. This concept embraces the expressions of the charismatic movement that, in the last decades, have begun to use the means of communication to expand the reach of its evangelizing action. From this point of view, this aspect of the Brazilian Catholicism offers comfort and an idea of Salvation against the evils experienced by millions of Brazilians. Furthermore, according to the current ecclesial situation, the research takes into account the new moment experienced by the Catholic Church with the pontificate of Pope Francis. This man wishes to encourage a reform of the Church in a missionary way, so that the ecclesiastical institution can rediscover, as its main role, the proclamation and witness of whole Salvation in Jesus Christ. Therefore, after a historical-sociological analysis of the modernization process of the Brazilian religious field (which allowed the emergence of Media Catholicism), as well as the selected texts produced by this religiosity and which are the object of research, the study also intended to critically analyze the material collected in the light of the pope s theology. The goal is to investigate the contributions and contradictions of Media Catholicism to the Salvation proposal announced by Pope Francis, besides presenting alternatives that allow for greater collaboration with his pontificate.

[pt] O presente trabalho visa analisar o uso de drogas como uma via para regulação do mal estar na contemporaneidade. Para tal realizou se uma pesquisa com proposta interdisciplinar e de cunho teórico, em que são elencados autores de diferentes saberes dentre as Ciências Humanas, como a Psicanálise, Sociologia e Filosofia, e as Ciências da Saúde. Com ênfase na literatura psicanalítica, citamos textos de autores clássicos, como, por exemplo, os freudianos e ferenczianos, para assim, tecermos considerações a respeito do uso de drogas e da contemporaneidade dialogando com autores mais atuais. No primeiro capítulo da pesquisa abordamos a Saúde Pública, discutimos a Redução de Danos como um recurso que auxilia o sujeito a lidar com o mal estar, abordamos o aumento do consumo de drogas durante a pandemia do Covid 19 e consideramos os aspectos sociais, a sociedade do espetáculo e da performance; n o segundo capítulo analisamos os mecanismos da incorporação e introjeção e sua vinculação com o uso de substâncias psicoativas, discorremos sobre a função da droga para o sujeito, diferenciando as modalidades de uso, os tipos de uso não compulsivo do uso compulsivo do toxicômano e de modo mais específico nos detemos a discorrer sobre o fenômeno da Toxicomania no terceiro capítulo, são abordadas as expressões pulsionais contemporâneas das pulsões de Eros e Tânatos o trauma do sujeito e as relações objetais, as quais nos remetem a dinâmica do objeto droga. Reconhecemos os potenciais prejuízos das drogas, sobretudo a depender da forma como ela é utilizada, e percebemos o lugar de importância que ela ocupa na dinâmica psíquica do sujeito. / [en] This work aims to analyze the use of drugs as a way to regulate malaise in contemporary times. To this end, a research was carried out with an interdisciplinary proposal and of a theoretical nature, in which authors of different knowledge among the Human Sciences, such as Psychoanalysis, Sociology and Philosophy, and the Health Sciences are listed. With an emphasis on psychoanalysis, we cite texts by classic authors, such as, for example, the Freudians and Ferenczian s in order to make considerations about drug use and contemporaneity, dialoguing with more current authors. In the first chapter of the research, we address Public Health, we discuss Harm Reduction as a resource that helps the subject to deal with malaise, we address the increase in drug consumption during the Covid 19 pandemic and we consider the social aspects, the society of the spectacle and of performance; in the second chapter, we analyze the mechanisms of incorporation and introjection and their connection with the use of psychoactive substances, we discuss the drug s function for the subject, differentiating the modalities of use, the types of non compulsi ve use of the compulsive use of the drug addict, and more specifically, we stop to discuss the phenomenon of drug addiction in the third chapter, the contemporary instinctual expressions of the impulses of Eros and Tanatos, the subject s trauma and object relations are approached, which refer us to the dynamics of the drug object. We recognize the potential harm caused by drugs, especially depending on how it is used, and we realize the important place it occupies in the subject s psychic dynamics.

Patients with classical vitiligo lose partially their protecting inherited pigment. The cause of the disease is still unknown. Despite massive epidermal oxidative / nitrative stress and signs for DNA-damage in the skin and in the plasma, these patients have no higher prevalence for sun induced non-melanoma skin cancer and increased photo-damage. Protection and DNA-repair have been attributed to a functioning up-regulated wild type p53 / p21 cascade in association with up-regulated p76 MDM2. As some patients with cutaneous melanoma develop depigmentations away from their primary tumour site post surgical excision, it became of our interest, whether this melanoma associated leucoderma (MAL) is the same as classical vitiligo. The purpose of this thesis was two-fold. In part I, we wanted to further substantiate the reasons behind the constantly up-regulated wild-type functioning p53 / p21 cascade in classical vitiligo utilising a panel of proteins with direct and / or indirect action on p53 regulation, including p21, p76MDM2, MDM4/MDM4phospho, SPARC, VEGF-A and TGF-β1. In part II, we wanted to characterize MAL and compare this peculiar leucoderma with classical vitiligo using the same protein panel and methodologies. To achieve our goals, we used in vivo FT-Raman spectroscopy, in vitro cell cultures, in vitro and in situ immuno-fluorescence labelling, Western blot, dot blot and computer modelling techniques. Our data showed distinct differences between classical vitiligo and MAL. Our results in MAL exhibited a concentration dependent protein expression gradient between the basal / suprabasl layers and the upper layers of the epidermal compartment using catalase, ONOO-, p53, p21, MDM4, p76MDM2, TGF-β1 and VEGF-A expression gradient. Moreover, we document for the first time the presence of a nitrated non-fuctional SPARC protein in classical vitiligo which is absent in MAL. Although we show in vivo considerable ROS / RNS- mediated stress in MAL and classical vitiligo documented by FT-Raman spectroscopy, Western blot and in situ immuno-fluorescence, our results prove that MAL and classical vitiligo are two distinct entities.

No description available.

Progression d'un concept, le mal radical, dans trois textes :La Religion dans les limites de la simple raison (Kant), Le système de l'Ethique (Fichte), et Le Traité de 1809 (Schelling). Origine ultime du mal :libre arbitre ou détermination ?Responsabilité et liberté du mal. Mal moral et métaphysique du mal/ Advance of a concept: radical evil, in three readings: Religion within the Limits of Mere Reason (Kant), System of Ethics (Fichte), and Treatise of 1809 (Schelling).Ultimate origin of evil: free will or determination? Responsibility and freedom to evil. Moral evil and metaphysics of evil. / Doctorat en Philosophie / info:eu-repo/semantics/nonPublished

This thesis demonstrates that geological setting, depositional facies, open system flux of hot basinal brines and descending of shallow waters have a strong impact on the distribution of the diagenetic alterations within continental and paralic/shallow marine sandstones which in turn control the quality and heterogeneities of the reservoirs. Geological setting controls the mineralogical and textural maturity of sandstone, whereas depositional facies control the pore water chemistry (marine, brackish or meteoric), sedimentary texture and sand body geometry. Eogenetic alterations in the fluvial deposits are dominated by precipitation of infiltrated clays, kaolinitization of detrital silicates, whereas the shallow marine deposits are dominated by precipitation of early calcite and kaolinite. Conversely mesogenetic alterations are dominated by clay minerals transformation, quartz overgrowths and Ferroan- carbonates, barite and anhydrite. Flux of hot basinal brines is evidenced by precipitation of mesogenetic minerals that lack of internal sources (e.g. barite, anhydrite and ferroan carbonate cements), which is evidenced by: (1) restricted occurrence of these minerals in downthrown blocks. (2) The high fluid inclusion homogenization temperatures (Th) of quartz overgrowths (Th &gt; 110-139°C), and carbonate cements (T &gt; 80-140°C), which also have light δ18OV-PDB(-17.6‰ to -6.7‰). Flux of hot basinal brines is further evidenced by occurrence of saddle Fe-dolomite along stylolites. Fluid inclusion microthermometry further revealed a dramatic shift in pore- water chemistry from NaCl dominated brines during precipitation of quartz overgrowths to NaCl-CaCl2 dominated brines during cementation by Fe-dolomite. Presence of mixed brine (NaCl+CaCl2) systems in the fluid inclusions suggests flux of descending waters, which have circulated in the overlying carbonate-evaporite successions. The restricted occurrence of oil- filled inclusion to quartz overgrowths and methane to Fe-carbonate cements suggest migration of oil during precipitation by quartz and migration of methane during precipitation by Fe- carbonate cements. The extensive mesogenetic cements in the down thrown blocks is attributed to flux of basinal brines along deep seated faults, i.e. open system diagenesis. Integration of fluid inclusion microthermometry, isotopes, Raman spectrometry and thermal tectonic evolution of basins are essential techniques for unraveling the evolution of basinal fluids, cementation conditions and relative timing of hydrocarbons migration. / <p>Errata: Felaktigt disputationsdatum på spikbladet.</p>

Thèse numérisée par la Division de la gestion de documents et des archives de l'Université de Montréal.

Le premier verset de la Genèse raconte qu’au commencement, Dieu créa le ciel et la terre. Le monde, sa forme et sa matière, de même que le temps, soutient Augustin, surgissent alors dans l’être, à partir de rien, en un seul instant, celui de la Création. Censés couronner l’œuvre créatrice, l’homme et la femme, pourtant, ne tardent pas à rompre le lien de confiance qui les unit à leur Créateur, en faisant mauvais usage d’une chose bonne : leur liberté. À cause de sa première transgression, nous dit Augustin, l’humanité portera désormais la marque du péché, que seule la figure rédemptrice du Christ, le Second Adam, pourra effacer, grâce au pardon donné à tous ceux qui choisissent d’emprunter sa voie. Or, en raison de son désir irrépressible de connaître et de faire l’expérience du monde par le biais de son propre être donné, soumis au changement, l’homme semble perpétuellement tenté par la transgression des limites essentielles de sa relativité à Dieu. Pourtant, Dieu, l’unique créateur de l’être des choses créées, crée toute chose bonne, du moins dans une certaine mesure : le mal dont semblent caractérisés l’être même et les actions des hommes, correspond, en vérité, aux multiples degrés de bien qui résultent d’une privation plus ou moins grande du Bien suprême qu’est Dieu. Berbère de culture romaine, témoin et acteur des derniers jours de l’Antiquité, penseur bouillonnant et théologien essentiel, Augustin laissera une œuvre importante et féconde. Nous tenterons ici de comprendre le contexte d’émergence de sa doctrine du péché originel. / The first verse of Genesis says that in the beginning, God created the heavens and the earth. The world, its form and matter, and time, argues Augustin, arose in Being out of nothing, in one single instant, that of the Creation. Conceived as the coronation of Creation, man, however, quickly breaks the trust relationship with his Creator, and does this by making evil use of a good thing: his free will. Because of its first transgression, says Augustine, humanity will, from now on, bear the mark of sin, which only the redemptive figure of Christ, the Second Adam, can erase, for all of those willing to follow his path. Yet, because of his irrepressible desire to acquire knowledge and experience of the world through his own given being, subject to change, man appears to be perpetually tempted by the transgression of his essential relativity to God. God, however, being the sole creator of the very being of created things, creates all things good, but to a certain degree: evil, which seems to characterize the being and actions of men, in reality, corresponds to varying degrees of goodness, which themselves result from more or less privation of the Supreme Good, namely, God. Berber of roman culture, witness and actor of the last days of Antiquity, passionate thinker and essential theologian, Augustine has produced some of humanity’s most important writings. In this work, we will attempt to understand the context which led to the emergence of his doctrine of original sin.

Ce mémoire porte sur la relation de l'œuvre de Sade à la modernité. De Sade qui, en ce qu'il ne s'est pas laissé aveugler, qu’il a su voir l'obscurité immanente aux Lumières, doit être considéré comme un voyant. Ce que d'aucuns appellent sa folie, c'est-à-dire la raison naturelle, bourgeoise par lui chantée et exacerbée, c'est un miroir tourné dans notre direction, un miroir dans lequel nos sociétés refusent de voir leur propre raison instrumentalisée, leur propre raison mise au service de l'égoïsme, de l'autoconservation. Face à ce refus, l'œuvre de Sade apparaît comme le refoulé de notre modernité. Dans un premier temps, ce mémoire examine la filiation esthétique de Sade à Baudelaire et s'attache, par l'entremise d'une étude comparative des figures du libertin et du dandy, à démontrer comment l'esthétique négative de Baudelaire présuppose la conception sadienne du mal comme intimement lié à la nature et à la raison, comment elle la transfigure de sorte que c'est seulement à partir de cette conscience dans le mal que Baudelaire en arrive à penser le bien, qu'elle constitue pour lui la seule possibilité de se réformer, de devenir à la fois humain et lucide. Il faut toujours en revenir à de Sade pour expliquer le mal, écrit Baudelaire, qui fait ainsi de Sade ou du moins de son fantôme, puisque celui-ci n'est que rarement nommé, une figure clé de la conscience dans le Mal, condition sine qua non de la modernité baudelairienne. Dans un second temps, c'est à la notion de petite souveraineté que s'intéresse ce mémoire. Souveraineté par procuration qui interdit la réelle souveraineté, elle est le produit de l'assujettissement du libertin à la nature, à la Raison, cette Raison naturelle et bourgeoise. Et l'éducation naturelle par laquelle le libertin cherche à assujettir l'Autre, lui qui ne peut posséder qu'en soumettant autrui au système auquel lui-même s'est consciemment soumis, lui le possédé-possédant, le fantôme d'homme faiseur de fantômes lui-même, est reproduction à son compte de son propre assujettissement. Cette notion de petite souveraineté s'oppose à une tradition de critiques idéalistes, qui, se méprenant sur la parenté du dandy et du libertin, héroïsant ce dernier, voient en lui un sujet libre, souverain, sans se rendre compte que sa Raison est historiquement lourde de conséquences. / This essay examines the relation of de Sade's works with modernity. De Sade is a visionary: he wasn't blinded by the Enlightment, in which he saw an inherent darkness. What some perceived as his madness — the natural reason, the bourgeois reason which he celebrates and exacerbates — is a mirror of our own, a mirror in which our societies refuse to see themselves and their own utilitarian reason, guided by opportunism and self-conservation. This refusal shows de Sade's works as a part of our modernity which we seek to suppress — de Sade as le refoulé de notre modernité. First, this essay looks at the esthetic filiation from de Sade to Baudelaire and, by comparing de Sade's libertine and Baudelaire's dandy, shows how the negative esthetic of Baudelaire presupposes de Sade's conception of Evil as a product of nature and reason, and how it transfigures this conception in such a way that Good can only proceed of this awareness in Evil, through which lies the only possibility to become at once human and lucid. One must always go back to de Sade to understand Evil, writes Baudelaire, who thus highlights de Sade's — or rather a ghost of de Sade, as his name is seldom mentioned in Baudelaire's — key role in this concept of conscience dans le Mal, making him the sine qua non condition of his modernity. The second part of this essay analyzes the notion of petite souveraineté. This borrowed sovereignty, which forbids the real sovereignty, is the product of the libertine's subjection to nature and to Reason, i.e. to the bourgeois and natural Reason. The natural education by which the libertine — he who can only possess by submitting the other to the system to which he consciously submitted himself, the possessed yearning to possess, the man reduced to a ghost who create ghosts himself — wants to dominate the Other(s) is a reproduction for himself of his own subjection. This notion of petite souveraineté confronts a tradition of idealistic critics who see in the libertine the subject of a total liberty, a sovereign subject – and thus who don't notice that the historical meaning of his Reason is laden with consequences.

Mémoire numérisé par la Division de la gestion de documents et des archives de l'Université de Montréal.