In the traditional agenda-setting theory, the agenda-setters were the news media and the public has a minimal role in the process of agenda-setting, which makes the public a passive receiver located at the bottom in the top-down agenda-setting dynamics. This study claims that with the development of Information communication technologies, primarily social media, the networked public may be able to set their own agendas through connective actions, outside the influence of the news media agenda. There is little empirical research focused on development and dynamics of public agenda-setting through social media platforms. Understanding the development and dynamics of public agenda-setting may be key to accounting for and overcoming conflicting findings in previous reverse agenda-setting research. This study examined the public agenda-setting dynamics through a case of gun violence prevention activism Twitter network, the #MarchForOurLives Twitter network. This study determined that the agenda setters of the #MarchForOurLives Twitter network are the key Never Again MSD student leaders and the March For Our Lives. The weekly reflected important events and issues and the identified topics were highly co-related with the themes examined in the tweets created by the agenda setters. The amplifiers comprised the vast majority of the tweets. The advocates and the supporters consisted of 0.44% and 4.43% respectively. The tweets made by the agenda setters accounted for 0.03%. The young activists and the like-minded and participatory public could continuously make changes taking advantage of technologies, and they could be the hope in the current and future society.

This thesis sets out to demonstrate the role of Western missionaries and Korean Christians, especially Protestants, on Korean nationalism. The first significant introduction of Protestantism into Korea came in 1884. Within just over thirty years, the Protestant Church in Korea expanded and many of the nationalist leaders took active roles in the Korean nationalist movement against Japanese imperialism. This thesis consults both Western and Korean primary sources including period newspapers. Some of the Korean primary sources were translated from Korean into English and others were originally written in English by Koreans. Also consulted are many valuable secondary sources which help further shed light on the subject at hand and give credence to the thesis. Chapters 2-4 show the direct contributions of Western missionaries to Korean nationalism and Chapters 5-7 show the indirect contributions of Western missionaries by the direct involvement of Korean Christians in their fight for independence against the old Korean order and Japan.

Splines are a common mixed-initiative technique for road generation. A designer draws the shape of the curve but the mesh can be procedurally generated along the spline. This relationship improves the workflow of building roads in virtual environments and video games without taking away all of the control of the designer. Whilst this technique is useful when building single roads such as race tracks, it unfortunately struggles when dealing with more complex road networks that feature intersections. These intersections struggle with overlapping meshes and flickering textures without a straightforward solution. This problem significantly limits the usefulness of spline tools when generating roads. This paper aims to solve part of this problem by suggesting a method for detecting intersections in splines that support procedural mesh generation.

Although the Council House Fight is well written about in the annals of early Texas history, this all-encompassing study will reveal a whole new picture. Unlike previous works that maintained one point of view, multiple perspectives were analyzed and explored to allow a more comprehensive view of the Council House Fight to emerge. Primary focus on social and cultural misunderstandings, as well as the mounting hostility between the Penateka Comanche and Texians across the frontier, will demonstrate their general distrust and hatred of the other. Detailing their complicated relationship will prove that neither the Texians nor the Comanche were without blame, and both shared responsibility for the deterioration of events on and before March 19, 1840.

No description available.

<p><strong>ABSTRACT </strong> Approximating the kinetic energy as a functional of the electron density is a daunting, but important, task. For molecules in equilibrium geometries, the kinetic energy is equal in magnitude to the total electronic energy, so achieving the exquisite accuracy in the total energy that is needed for chemical applications requires similar accuracy for the kinetic energy functional. For this reason, most density functional theory (DFT) calculations use the Kohn-Sham method, which provides a good estimate for the kinetic energy. But the computational cost of Kohn-Sham DFT calculations has a direct dependence on the total number of electrons because the Kohn-Sham method is based on the orbital picture, with one orbital per electron. Explicit density functionals, where the kinetic energy is written explicitly in terms of the density, and not in terms of orbitals, are much faster to compute. Unfortunately, the explicit density functionals in the literature had disappointing accuracy. This dissertation introduces several new approaches for orbital-free density functional methods. One can try to include information about the Pauli principle using the exchange hole. In the weighted density approximation (WDA), a model for the exchange hole is used to approximate the one-electron density matrix, which is then used to compute the kinetic energy. This thesis introduces a symmetric, normalized, weighted density approximation using the exchange hole of the uniform electron gas. Though the key results on kinetic energy are not accurate enough, an efficient algorithm is introduced which, with a more sophisticated hole model, might give better results. The effects of electron correlation on the kinetic energy can be modeled by moving beyond the one-electron distribution function (the electron density) to higherorder electron distributions (k-electron DFT). For example, one can model electron correlation directly using the pair electron density. In this thesis, we investigated two different functionals of the pair density, the Weizsäcker functional and the March-Santamaria functional. The Weizsäcker functional badly fails to describe the accurate kinetic energy due to the N-representability problem. The March-Santamaria functional is exact for a single Slater determinant, but fails to adequately model the effects of electron correlation on the kinetic energy. Finally, we established a relation between Fisher information and Weizsäcker kinetic energy functional. This allowed us to propose generalisations of the Weizsäcker kinetic energy density functional. It is hoped that the link between information theory and kinetic energy might provide a new approach to deriving improved kinetic energy functionals. <strong> Keywords: </strong><em>Kinetic energy functional, Density functional theory (DFT), von-Weizsäcker</em> <em> functional, March-Santamaria functional, Thomas-Fermi model, density matrix, Twopoint normalization, Pair-density functional theory (PDFT). </em></p> / Doctor of Science (PhD)

This diploma thesis compares impact of various high-energy grinding technologies on crystallographic and granulometric properties of portland cement. It also observes the influence of the conventional and high-speed grinding technology on the resulting physical and mechanical properties of portland cement, depending on the storage time.

Le règne de Charles le Chauve fut une période de transformations politiques et idéologiques pour la royauté carolingienne. Les conflits de la marche de Bretagne et d’Espagne ainsi que les incursions externes sont les troubles ayant probablement le plus retenu l’attention des médiévistes. La prétendue quête émancipatrice des Armoricains ou encore les ambitions personnelles et familiales des magnats aristocratiques septimaniens et ibériques sont encore citées comme preuves de l’affaiblissement du pouvoir royal carolingien, suite au traité de Verdun de 843. En s’attardant sur les politiques de résolution de conflit du roi dans ces deux territoires, à priori hostiles à son pouvoir, ce mémoire veut établir si les tensions dans les marches étaient aussi complexes et insurmontables que les sources primaires le laissent entendre. En comparant les politiques de terrain visibles dans les actes royaux, nous remarquons que ces troubles n’étaient pas fondamentalement différents de ceux présents ailleurs dans le royaume. Les stratégies employées par le souverain montrent que la royauté détenait les moyens de venir à bout des obstacles à sa suprématie politique. Visiblement, ces dissidences ne semblent pas aussi particulières. Les enjeux politiques et économiques qu’elles impliquaient étaient, de toute évidence, à l’image des principales préoccupations politiques des rois carolingiens suite à la guerre civile de 840-843. Il importait d’argumenter leur légitimité divine ainsi que d’apparaître comme le seul choix politique. / Charles the Bald’s reign was a period of political and ideological transformations for the carolingian royalty. The troubles with the Breton and Spanish march along with the external raids are probably the sources of tension which have captured the most attention from medievalists. The so-called armorican emancipatory quest or the personal and familial ambitions of the septimanian and iberian magnates are still cited as evidences of the weakening of Carolingian political power following the 843 treaty of Verdun. By focusing on the king’s conflict resolution policies in these two territories, apparently hostile to his power, this study wants to establish wheter the tensions in the marches were as complex and irremediable as the primary sources suggested. By comparing the field policies visible in the royal charters, we noticed that theses troubles were not fundamentally different from those present elsewhere in the kingdom. The strategies employed by the king shows that the royalty had the means to overcome these obstacles and to affirm his political supremacy. Noticeably, these oppositions do not seem to be so particular. The political and economic issues that they were impliying were reflecting the main political concerns of the Carolingian kings following the 840-843 civil war. It was important to them to promote their divine legitimacy as well as appearing as the only political choice for the kingdom’s elites.

La chaîne invariante forme un complexe nonamérique avec les molécules classiques du CMH de classe II. HLA-DM et HLA-DO, des molécules non-classiques de classe II, sont aussi impliquées dans la présentation des peptides antigéniques aux lymphocytes T. Ces molécules chaperones de la présentation antigénique modulent la capacité d’une cellule à présenter des antigènes par les moloécules classiques du CMH de classe II. La régulation transcriptionnelle des molécules chaperones, tout comme celle des autres molécules du CMH de classe II, est assurée par le transactivateur CIITA. La molécule HLA-DR peut être régulée négativement de manière post-traductionnelle par ubiquitination grâce à l’enzyme E3 ubiquitine ligase MARCH1. Celle-ci est induite par l’interleukine-10 dans les monocytes. L’objectif de ce projet était de déterminer si l’ubiquitination par MARCH1 peut aussi réguler l’expression des molécules chaperones de la présentation antigénique. Les expériences furent réalisées dans le contexte de co-transfections en cellules HEK293T. L’expression des molécules fut évaluée par immunomarquages et cytométrie de flux. Il a été montré que l’isoforme p33 de la chaîne invariante est régulé négativement en présence de MARCH1 à partir de la surface cellulaire, causant ainsi sa dégradation. Tel que démontré par l’utilisation d’un mutant dépourvu de queue cytoplasmique, cette dernière région n’est pas indispensable à ce phénomène. Une hypothèse est qu’une molécule non-identifiée, associée à Ii, serait ubiquitinée par MARCH1, l’entraînant dans sa régulation négative. Il fut déterminer que cette molécule n’était pas CXCR2, un récepteur pouvant être impliqué, avec la chaîne invariante et CD44, en tant que récepteur de MIF (Macrophage Inhibitory Factor). Il fut aussi montré que HLA-DO peut être ciblé par MARCH1 mais ceci ne semble pas être un phénomène dominant; l’expression des complexes DO/DM n’étant pas affectée bien qu’ils entrent en interaction avec MARCH1. L’expression de HLA-DM n’est pas affectée par MARCH1. Il n’a toutefois pas été déterminé hors de tout doute si MARCH1 peut modifier DM; des résultats obtenus avec une queue cytoplasmique de DM possédant une lysine laissant suggérer qu’il est possible que MARCH1 interagisse avec DM. Dans l’ensemble, les travaux démontrent que l’ubiquitination par MARCH1 joue un rôle dans la régulation post-transcriptionnelle de la chaîne invariante p33 mais pas HLA-DO et HLA-DM. / The invariant chain, which form a nonameric complex with the classical MHC class II molecules. HLA-DM and HLA-DO (non-classical class II molecules) are involved in the presentation of antigens to T lymphocytes. The chaperons molecules of the antigenic presentation can modulate the capacity of the cells to present antigens. The transcriptional regulation of the chaperons and all of the other molecules linked to the MHC is assured by the CIITA transactivator. Little is know of the post-transcriptional mechanisms, other than the fact that HLA-DR molecule can be down-regulated by ubiquitination due to E3 ubiquitin ligase MARCH1. MARCH1 is induce by interleukin-10 in monocytes. The goal of this project is to figure out if ubiquitination by MARCH1 can also regulate the expression of the antigenic presentation chaperons. The experiences were performed in the context of co-transfections in HEK293T cells and the expression of the diverses molecules was evaluated by cell stainings and FACS analysis. The p33 isoform of the invariant chain was found to be down-regulated and degraded in the presence of MARCH1. The invariant chain cytoplasmic tail is not completely essential to this phenomenon; a non-identified molecule, associated with Ii, is probably ubiquitinated by MARCH1 and is then down-regulated, together with Ii. It was shown tha CXCR2, a reeptor involved with the invariant chain and CD44 in the reception of the MIF signal, is not that molecule. HLA-DO can ben targetd by MARCH1 but this does not seem to be a general phenomenon; the expression of the DO/DM complexes remaning unaffected even with the interaction of those complexes with MARCH1. Therefore, a certain protection seem to be provided by HLA-DM to HLA-DO. The expression of HLA-DM itself is not affected by the presence of MARCH1. However, it was not cleary demonstrated if MARCH1 can modify DM. Some results obtained with a cytoplasmic tail of DM comprising an additional lysine suggest that there is a possibility that MARCH1 interact with DM. Generally, the work presented here show that ubiquitination by MARCH1 is involved in post-transcriptionnal regulation of the p33 isoform of the invariant chain but not in the regulation of HLA-DO and HLA-DM.

Approved for public release; distribution in unlimited. / Since the end of the Cold War the Alliance's transformation has erased doubts about its survival. NATO continues to adapt to new threat environments by expanding its mission scope to out-of-area operations and by assuming new security missions. For the 2004 Summer Olympics in Athens, Greece, the 11 September 2001 terrorist attacks against the United States and subsequent 11 March 2004 Madrid bombings in Spain complicated an already robust Greek security plan. Greece's extensive security planning, in addition to coordinating NATO support, highlighted the challenges and readiness requirements for the Alliance in the 21st century. Terrorist concerns, burden-sharing, recognition of Greek sovereignty, political limitations in deploying NATO's CBR Defense team and NRF utilization were all elements of the challenges faced in security preparation for the Games. In assessing the dynamics behind NATO's history and its security participation in the 2004 Summer Olympics, this thesis serves as a case study in the continuing transformational role and adaptability of NATO. Overall, the Alliance's willingness to assume security support to a major international sporting event represented its long-time relationship with Greece, its ability to perform significant security missions and its commitment to and solidarity with its allied members. / Lieutenant, United States Navy