According to the dominant approach in the theory of vagueness, the nature of the vagueness of an expression ‘F’ consists in its presenting borderline cases in an appropriately ordered series: objects which are neither definitely F nor definitely not F (where the notion of definiteness can be semantic, ontic, epistemic, psychological or primitive). In view of the various problems faced by theories of vagueness adopting the dominant approach, the thesis proposes to reconsider the naive theory of vagueness, according to which the nature of the vagueness of an expression consists in its not drawing boundaries between any neighbouring objects in an appropriately ordered series. It is argued that expressions and concepts which do present this feature play an essential role in our cognitive and practical life, allowing us to conceptualize—in a way which would otherwise be impossible—the typically coarse-grained distinctions we encounter in reality. Despite its strong initial plausibility and ability to explain many phenomena of vagueness, the naive theory is widely rejected because thought to be shown inconsistent by the sorites paradox. In reply, it is first argued that accounts of vagueness based on the dominant approach are themselves subject to higher-order sorites paradoxes. The paradox is then solved on behalf of the naive theory by rejecting the unrestricted transitivity of the consequence relation on a vague language; a family of logics apt for reasoning with vague expressions is proposed and studied (using models with partially ordered values). The characteristic philosophical and logical consequences of this novel solution are developed and defended in detail. In particular, it is shown how the analysis of what happens in the attempt of surveying a sorites series and deciding each case allows the naive theory to recover a "thin" notion of a borderline case.

本論文共分六章九節，全篇計九萬餘言。第一章緒論，敘述在中國東 北地區的韓人社會背景及本論文的研究旨趣。第二章是義兵與獨立軍在中 國東北的發展，分為三節；第一節了解獨立軍的母體，即舊韓末時期的義 兵形成，義兵展開的反日活動、義兵追求的民族精神以及「三一運動」的 爆發與其影響；第二節敘述獨立軍歷史的背景、獨立軍在中國東北發展的 原因、各獨立軍團體的建立及發展過程；第三節主要述及「韓日合併」後 的在中國東北地區義兵活動與義兵對獨立軍團組織產生的作用。第三章是 獨立軍的組織､養成及裝備，分為兩節；第一節由獨立軍內部組織，觀察 主導勢力情況、及其思想及追求的理念、運用軍隊行政方面的事項等；第 二節討論由養成獨立軍的徵兵制度實施、籌備軍費及武器等的問題。第四 章是獨立軍的戰鬥活動，共分兩節；第一節依時間順序敘述，獨立軍的活 動以表和圖來說明獨立軍攻擊韓國境內的活動狀況；第二節由在中國東北 的獨立軍與日軍交戰中，探討獨立軍的對戰爭的態度、戰役經過、及戰役 影響等。第五章是獨立軍的發展與國際關係，共分兩節；第一節分析中國 政府對中國東北獨立軍活動之取締與放任；第二節主要論及在中國東北的 獨立軍活動所帶來的中、日兩國之間的交涉及處理韓民問題。第六章結論 ，綜述本文研究成果，而了解在中國東北地區韓人獨立運動史上的地位。

This research report focuses on the issues for participation in public memory projects, in the light of counter-monument critiques of audiences being ‘rendered passive’. Interviews with people who went on the 2005 March of the Living tour to Holocaust sites in Poland and then to Israel have been analysed in terms of themes and processes of meaningmaking. The written text of some of the material provided to them is also analysed. Meanings in the interviews notably occupied two discursive spaces that seem at odds with each other. The first was the discourse around what is a good way to memorialise – particularly when the memory is one of such enormity as the Holocaust. The second is the discourse around tolerance education – how do we ‘learn lessons’ from the Holocaust? The issues for heritage interpretation and tolerance education are explored.

Made available in DSpace on 2016-04-25T20:21:16Z (GMT). No. of bitstreams: 1 Daniel Lopes Faggiano.pdf: 5844871 bytes, checksum: 78e8a18987a4c12c0dc4afc6d143acf6 (MD5) Previous issue date: 2014-09-11 / Conselho Nacional de Desenvolvimento Científico e Tecnológico / In our transition process to the production and reproduction of capital mode through a colonial via, we plated a particular colonial capitalism in the tropics. Colonial, since it develops itself in atrophy, not completely, keeping and reinforcing Brazil as an subaltern bond of the imperialism. Considering the particularity of each author, I remark the works of Caio Prado Jr., Francisco Oliveira, Florestan Fernandes, José Chasin, Octavio Ianni e Maurício Tragtenberg as fundamentals in the marxist formulation of the Brazilian thoughts. The current work starts from The Brazilian March to West, searching our historical particularity. Moved by a late industrialization of the country, the myth of development takes violently all Brazilian people to be submitted to this cause, while the profits pass to be concentrated, even more, in the hands of farmers, national and international dealers. The domination of value of change by the value of use, contradictory present in the products of capitalist civilization, together with the transformation of lands to capital- private property, reaches the limits of Parque Indígena do Xingu (MT) and, slowly, charmingly penetrates the daily life of the aldeias. Considering the studies made since 1965 by the anthropologist Carmen Junqueira, this work intends to critically analyze the arriving of the goods with its values and of the capital-social relation in the aldeia Kamaiurá from Ipavu, analyzing the way the sociability of capital breaks up the existing collectivity, besides pointing out the arrangements and adjustments made by the Kamaiurá when facing the destructive process of our colonial capitalism. This work, contemporary to the capital s crisis era, searches to confront the Brazilian reality without loosing its human horizon, ontological. At last, it defends that the Kamaiurá s way of life, anchored in the collective element of their land, may be put, humanly, against the capital and open, consciously, free paths among the rubble of the amplified production and reproduction of life under the capital / Em nosso processo de transição ao modo de produção e reprodução do capital através de uma via colonial, forjamos um capitalismo particular nos trópicos. Colonial, sim, pois se desenvolve de maneira atrófica, de modo incompleto, perpetuando e acentuando o Brasil como elo subalterno do imperialismo. Sem apagar as particularidades de cada autor, destaco os estudos de Caio Prado Jr., Francisco Oliveira, Florestan Fernandes, José Chasin, Octavio Ianni e Maurício Tragtenberg como essenciais na formulação marxista do pensamento brasileiro. O presente estudo parte da Marcha para o Oeste brasileiro, buscando adentrar na particularidade histórica brasileira. Impulsionado pela industrialização hiper-tardia do país, o mito do desenvolvimento alça violentamente todo povo brasileiro aos mandos desta causa, enquanto o lucro passa a ser concentrado, ainda mais, nas mãos de fazendeiros e empresários, nacionais ou internacionais. A dominação do valor de troca pelo valor de uso, presente contraditoriamente nas mercadorias da civilização capitalista, junto com a transformação da terra em capital-propriedade privada, chega aos limites do Parque Indígena do Xingu (MT) e, aos poucos, penetra sedutoramente no cotidiano das aldeias. Com base nos estudos realizados desde 1965 pela antropóloga Carmen Junqueira, esta obra pretende analisar criticamente a chegada de mercadorias com seus valores e do capital-relação social na aldeia Kamaiurá de Ipavu, analisando de que modo a sociabilidade do capital fragmenta a coletividade ali existente, além de apontar os arranjos e rearranjos Kamaiurá em frente ao processo desestruturante de nosso capitalismo de extração colonial. Este trabalho, contemporâneo aos tempos de crise do capital em todo globo, procura enfrentar a realidade brasileira sem perder seu horizonte humano societário, ontológico. Por fim, defende-se que o modo de exteriorização da vida Kamaiurá, ancorado no elemento coletivo de suas terras, possa se colocar, humanamente, frente ao capital e abrir, de maneira consciente, caminhos livres por entre os escombros do modo de produção e reprodução ampliada da vida sob o capital

Orientador: Marcelo Carvalho Minhoto Teixeira Filho / Resumo: Gramíneas inoculadas com Azospirillum brasilense apresentam sistema radicular mais desenvolvido o que favorece a maior absorção de nutrientes e água, dessa maneira a extração de nutrientes durante o ciclo do milho, crescimento e produtividade da cultura podem ser maiores. Porém, a resposta a esta inoculação pode variar conforme a afinidade da bactéria com o genótipo da planta. Neste sentido, objetivou-se avaliar o acúmulo de matéria seca, extração de nutrientes e o índice de clorofila foliar (ICF) em diferentes estádios fenológicos, exportação de nutrientes pelos grãos, componentes de produção e produtividade de grãos de híbridos de milho inoculados ou não com A. brasilense. O experimento foi desenvolvido em Selvíria - MS, em um Latossolo Vermelho Distrófico em sistema plantio direto. O delineamento experimental foi em blocos ao acaso com 4 repetições, dispostos em um esquema fatorial 2 x 2, sendo dois híbridos de milho (DKB 390 VT PRO e DKB 350 VT PRO), inoculados ou não com A. brasilense na semente (200 mL ha-1 de inoculante líquido contendo as estirpes AbV5 e AbV6). Procedeu-se também a análise de regressão em esquema de parcela subdividida com 4 repetições, em que as parcelas foram constituídas pelos 4 tratamentos descritos acima, e as subparcelas por 6 épocas de coletas de plantas (V4, V8, R1, R2, R4 e R6), para avaliação do ICF, acúmulo de matéria seca e extração de nutrientes. A inoculação com A. brasilense propiciou maior acúmulo de matéria seca de raízes e total. O m... (Resumo completo, clicar acesso eletrônico abaixo) / Mestre

Made available in DSpace on 2016-04-26T14:54:58Z (GMT). No. of bitstreams: 1 Daniel Lopes Faggiano.pdf: 5844871 bytes, checksum: 78e8a18987a4c12c0dc4afc6d143acf6 (MD5) Previous issue date: 2014-09-11 / Conselho Nacional de Desenvolvimento Científico e Tecnológico / In our transition process to the production and reproduction of capital mode through a colonial via, we plated a particular colonial capitalism in the tropics. Colonial, since it develops itself in atrophy, not completely, keeping and reinforcing Brazil as an subaltern bond of the imperialism. Considering the particularity of each author, I remark the works of Caio Prado Jr., Francisco Oliveira, Florestan Fernandes, José Chasin, Octavio Ianni e Maurício Tragtenberg as fundamentals in the marxist formulation of the Brazilian thoughts. The current work starts from The Brazilian March to West, searching our historical particularity. Moved by a late industrialization of the country, the myth of development takes violently all Brazilian people to be submitted to this cause, while the profits pass to be concentrated, even more, in the hands of farmers, national and international dealers. The domination of value of change by the value of use, contradictory present in the products of capitalist civilization, together with the transformation of lands to capital- private property, reaches the limits of Parque Indígena do Xingu (MT) and, slowly, charmingly penetrates the daily life of the aldeias. Considering the studies made since 1965 by the anthropologist Carmen Junqueira, this work intends to critically analyze the arriving of the goods with its values and of the capital-social relation in the aldeia Kamaiurá from Ipavu, analyzing the way the sociability of capital breaks up the existing collectivity, besides pointing out the arrangements and adjustments made by the Kamaiurá when facing the destructive process of our colonial capitalism. This work, contemporary to the capital s crisis era, searches to confront the Brazilian reality without loosing its human horizon, ontological. At last, it defends that the Kamaiurá s way of life, anchored in the collective element of their land, may be put, humanly, against the capital and open, consciously, free paths among the rubble of the amplified production and reproduction of life under the capital / Em nosso processo de transição ao modo de produção e reprodução do capital através de uma via colonial, forjamos um capitalismo particular nos trópicos. Colonial, sim, pois se desenvolve de maneira atrófica, de modo incompleto, perpetuando e acentuando o Brasil como elo subalterno do imperialismo. Sem apagar as particularidades de cada autor, destaco os estudos de Caio Prado Jr., Francisco Oliveira, Florestan Fernandes, José Chasin, Octavio Ianni e Maurício Tragtenberg como essenciais na formulação marxista do pensamento brasileiro. O presente estudo parte da Marcha para o Oeste brasileiro, buscando adentrar na particularidade histórica brasileira. Impulsionado pela industrialização hiper-tardia do país, o mito do desenvolvimento alça violentamente todo povo brasileiro aos mandos desta causa, enquanto o lucro passa a ser concentrado, ainda mais, nas mãos de fazendeiros e empresários, nacionais ou internacionais. A dominação do valor de troca pelo valor de uso, presente contraditoriamente nas mercadorias da civilização capitalista, junto com a transformação da terra em capital-propriedade privada, chega aos limites do Parque Indígena do Xingu (MT) e, aos poucos, penetra sedutoramente no cotidiano das aldeias. Com base nos estudos realizados desde 1965 pela antropóloga Carmen Junqueira, esta obra pretende analisar criticamente a chegada de mercadorias com seus valores e do capital-relação social na aldeia Kamaiurá de Ipavu, analisando de que modo a sociabilidade do capital fragmenta a coletividade ali existente, além de apontar os arranjos e rearranjos Kamaiurá em frente ao processo desestruturante de nosso capitalismo de extração colonial. Este trabalho, contemporâneo aos tempos de crise do capital em todo globo, procura enfrentar a realidade brasileira sem perder seu horizonte humano societário, ontológico. Por fim, defende-se que o modo de exteriorização da vida Kamaiurá, ancorado no elemento coletivo de suas terras, possa se colocar, humanamente, frente ao capital e abrir, de maneira consciente, caminhos livres por entre os escombros do modo de produção e reprodução ampliada da vida sob o capital

Dans la première partie de ma thèse, nous avons étudié le rôle de la TSLP, une cytokine produite par les kératinocytes, dans la mélanogenèse. Nous avons montré que l'expression de TSLP était induite dans l'épiderme de la peau atteinte de mélanome chez la souris et l'humain. Notre resulats indiquent que la TSLP murine joue un rôle dans la croissance de la tumeur et que ce rôle s'exerçait via les cellules immunitaires. Nos résultats suggèrent l'existence d'un dialogue entre les cellules du mélanome, les kératinocytes et les cellules immunitaires jouant un rôle important dans la croissance et la métastase du mélanome. Dans la seconde partie, nous avons exploré les cytokines produites dans le contexte de la dermatite atopique et leur rôle dans l'initiation de l'asthme. Nous avons trouvé que TSLP est différemment impliquée dans la sensibilisation allergique épicutanée et dermocutanée, et nous avons identifiée l'IL-1β comme un acteur majeur dans la marche atopique. Cette étude expose de nouvelles approches pour le développement de stratégies pour prévenir ou stopper la marche atopique. / My PhD thesis aimed at studying skin inflammatory responses under two pathogenic contexts, melanoma and atopic march. In the first part, we studied the role of keratinocyte-produced cytokine TSLP in melanomagenesis. We showed that TSLP expression was induced in skin epidermis of both mouse and human melanoma. We further provided evidence that TSLP played a tumor-promoting role by ablating or overexpressing TSLP in mouse melanoma, and that such role of TSLP was mediated through immune cells. Our results suggest that a crosstalk between melanoma cells, epidermal keratinocytes and immune cells plays an important role for melanoma growth and metastasis. In the second part, we explored the cytokine factors derived from atopic dermatitis (AD) in driving the asthma. By using an innovative laser-assistant microporation system, we established novel atopic march mouse models. We found that TSLP was differentially implicated in allergen epicutaneous or dermacutaneous sensitization, and further identified IL-1β as an important player in atopic march. This study adds new insight into the development of potential strategies for preventing or stopping the atopic march.

Ph.D. / Molecular Microbiology and Immunology / Both poxviruses and γ2-herpesviruses share the K3-family of viral immune evasion proteins. These proteins are characterized by an amino-terminal RING-CH domain followed by two transmembrane domains. We analyzed several human homologues of the K3-family termed membrane-associated RING-CH (MARCH) proteins. All MARCH proteins localized to subcellular membranes while several reduced surface levels of known K3-family substrates. Thus, MARCH proteins appear to be structurally and functionally homologous to viral K3 proteins. One of the major challenges in determining the function of this family is the identification of their physiological substrates. To overcome this we created a quantitative proteomics approach which can be used to identify novel substrates for both the K3- and MARCH-families. Using stable isotope labeling by amino acids in cell culture, we compared the proteome of plasma membrane, golgi, and endoplasmic reticulum membranes in the presence and absence of K5 and MARCH-VIII. Quantitative mass spectrometric protein identification from these fractions revealed that CD316 (bone marrow stromal antigen 2), CD166 (activated leukocyte cell adhesion molecule) and syntaxin-4 were consistently underrepresented in the plasma membrane of K5 expressing cells, while CD44, CD81 (TAPA-1) and B-cell receptor-associated protein 31kDa (Bap31) were consistently underrepresented in the plasma membrane of MARCH-VIII expressing cells. Furthermore, downregulation of each of these proteins was independently confirmed. Our results both identify and characterize a novel family of human ubiquitin ligase enzymes and elucidate a novel technique which can analyze this family and be easily adapted to the analysis of other cellular enzymes viral immune modulators.

In this thesis I address the following questions: (1) How do dykes take up space in public in contemporary cities? (2) How does the ‘marching dyke’ emerge as a subject and what kind of subject is it? (3) How, in turn, do marching dykes affect space? In order to examine these questions I focus on the Toronto Dyke March to ask how it emerged in this particular time and place. The answer to each of these questions is paradoxical. I argue that the Dyke March is a complex, complicated and contradictory site of politics, protest and identity. Investigating ‘marching dykes’ reveals how the subject of the Dyke March is imagined in multiple and conflicting ways. The Toronto Dyke March is an event which brings together thousands of queer women annually who march together in the streets of Toronto on the Saturday afternoon of Pride weekend. My research examines how the March emerged out of a history of activism and organizing and considers how the March has been made meaningful for queer women’s communities, identities, histories and spaces. My analysis draws together queer and feminist poststructuralism, cultural geography literature on sexuality and space, and the history of sexuality in Canada. I combine a Foucaultian genealogy with visual ethnography, interviews and archival research. I argue that the Dyke March is an event which is intentionally meaningful in its claims to particular spaces and subjectivities. This research draws connections across various bodies of scholarship and offers an interdisciplinary contribution to the literature, contributing to discussions of queer women’s visibility and representation. Although my analysis is focused on Toronto as a particular site, it offers insight into broader queer women’s activist organizing efforts and queer activism in Canada.

In this thesis I address the following questions: (1) How do dykes take up space in public in contemporary cities? (2) How does the ‘marching dyke’ emerge as a subject and what kind of subject is it? (3) How, in turn, do marching dykes affect space? In order to examine these questions I focus on the Toronto Dyke March to ask how it emerged in this particular time and place. The answer to each of these questions is paradoxical. I argue that the Dyke March is a complex, complicated and contradictory site of politics, protest and identity. Investigating ‘marching dykes’ reveals how the subject of the Dyke March is imagined in multiple and conflicting ways. The Toronto Dyke March is an event which brings together thousands of queer women annually who march together in the streets of Toronto on the Saturday afternoon of Pride weekend. My research examines how the March emerged out of a history of activism and organizing and considers how the March has been made meaningful for queer women’s communities, identities, histories and spaces. My analysis draws together queer and feminist poststructuralism, cultural geography literature on sexuality and space, and the history of sexuality in Canada. I combine a Foucaultian genealogy with visual ethnography, interviews and archival research. I argue that the Dyke March is an event which is intentionally meaningful in its claims to particular spaces and subjectivities. This research draws connections across various bodies of scholarship and offers an interdisciplinary contribution to the literature, contributing to discussions of queer women’s visibility and representation. Although my analysis is focused on Toronto as a particular site, it offers insight into broader queer women’s activist organizing efforts and queer activism in Canada.