REIN JR., O. UM MODELO DE INTEGRAÇÃO ENTRE OS PADRÕES IEC 61850 E IEC 61970 (CIM/XML). 2006. 98 p. Dissertação Mestrado – Escola Politécnica, Universidade de São Paulo, São Paulo. A troca de informação entre os vários sistemas de gerenciamento e outros sistemas de informação de uma empresa do setor elétrico não é apenas desejada, mas, na maioria dos casos, necessária. Dois padrões internacionais surgiram, um relacionado à troca de dados nas subestações (IEC 61850) e outro relacionado à troca de informações entre os centros de controle (IEC 61970), sendo ambos publicados pelo comitê técnico 57 (TC57) do IEC, cujo tema é o gerenciamento e a troca de informação associados aos sistemas de potência. Contudo, apesar da similaridade em seu domínio de aplicação, cada um tem seu próprio modelo de objetos. O presente trabalho tem por objetivo investigar como a integração dos dados pertencentes aos sistemas de controle da subestação e do centro de controle pode ser alcançada, de maneira a permitir que a topologia de uma determinada subestação possa ser conhecida pelo EMS/SCADA. Vale, ainda, ter em conta que a verificação de tal análise demanda a implementação de um protótipo simulando a arquitetura de integração proposta. Logo, o estudo contempla as anotações que refletem os passos dessa implementação, bem como o registro dos testes exigidos pelos trabalhos, os quais compreenderam informações sobre a configuração de uma subestação contidos num arquivo SCL, informações de tempo real obtidas a partir de dispositivos eletrônicos inteligentes (IEDs), e a gravação desses dados em uma base de dados relacional modelada de acordo com o Common Information Model (CIM) contido na IEC 61970-301. / REIN JR., O An integration model between the IEC 61850 and IEC 61970 standards. 2006. 98 p. Dissertação Mestrado – Escola Politécnica, Universidade de São Paulo, São Paulo. The exchange of information among several management systems and other information systems of an electric utility company is not only desired but in most cases needed. Two international standards have emerged, one related to the data exchange of substations (IEC 61850) and another related to the exchange of information among control centers (IEC 61970), both published by the IEC technical committee 57 (TC57) that deals with the management and exchange of information on power systems. Nevertheless, in spite of the similarity in its application domain, each standard has its own object model. This work intends to investigate how to achieve the integration of data belonging to the substation control and control center systems, thus allowing a specific substation topology to be known by the EMS/SCADA. It is important to emphasize that the verification of such analysis required the implementation of a prototype to simulate the proposed integration architecture. Therefore, this work includes notes describing the implementation steps, as well as the record of the tests that have been done, encompassing substation configuration information within a SCL file, real-time information obtained from intelligent electronic devices (IEDs) and data recording in a relational database modeled according to the Common Information Mode (CIM) comprised in the IEC 61970-301.

This thesis work primarily focuses on the applicability of sub-threshold source coupled logic (STSCL) for building digital circuits and systems that run at very low voltage and promise to provide desirable performance with excellent energy savings. Sectors like bio-engineering and smart sensors require the energy consumption to be effectively very low for long battery life. Alongside meeting the ultra-low power specification, the system must also be reliable, robust, and perform well under harsh conditions. In this thesis work, logic gates are designed and analyzed, using STSCL. These gates are further used for implementation of digital subsystems in small-sized smart dust sensors which would operate at very low supply voltages and consume extremely low power. For understanding the performance of STSCL with respect to ultra-low power and energy; a seven-stage ring oscillator, a 4-by-4 array multiplier, a fifth-order FIR filter and finally a fifty-fifth-order FIR filter were designed. The subcircuits and systems have been simulated for different supply voltages, scaling down to 0.2 V, at different temperature values (-20oC and 70oC) in both 45 nm and 65 nm process technologies. The chosen architectures for the FIR filters and array multiplier were conventional and essentially taken from traditional CMOS-based designs. The simulated results are studied, analyzed and compared with same CMOS-based digital circuits. The results show on the advantage of STSCL-based digital systems over CMOS. Simulation results provide an energy consumption of 1.1388 nJ for a fifty-fifth-order FIR filter, at low temperatures (-20oC), using STSCL logic, which is comparatively less than for the corresponding CMOS logic implementation.

The main purpose of this thesis is to explore experiences of two different psychological interventions based on art psychotherapy in women with a psychological or physical illness. The two interventions are art psychotherapy and art therapy. The difference between these two interventions is that the art therapist works with the transference in art psychotherapy but not in art therapy. The thesis consists of two studies of art psychotherapy: An art psychotherapy intervention is evaluated in Study 1 (papers III and V) which examines a group of patients diagnosed with depression and Study 2 (paper II) which examines experiences in a group of six patients diagnosed with vulva vestibulitis. An art therapy intervention is evaluated in the third study (papers I and IV); where experiences in patients diagnosed with breast cancer are examined. In Study 1, forty-three (n=43) depressed women were randomly assigned to either an intervention group or a control group (verbal psychotherapy). The aim was to examine the outcome of time limited psychodynamic art therapy compared to time-limited psychodynamic verbal therapy for patients with depressive symptoms. Interviews were performed before, immediately after, and three months after the termination of psychotherapy, and self-rating scales which focus on stress reactions, depression and symptoms as well as an observer rating scale on depression were used. The interviews and the art sessions were video-recorded, and the verbal psychotherapy was tape-recorded. The results showed that the art and verbal psychotherapies were comparable. The conclusion was that short-term psychodynamic art psychotherapy could be a valuable treatment for depressed women. In an in-depth content analysis, the method of scribbling was further investigated and exemplified with the therapies of two participants. In this study, the patients’ pictures and verbal expressions of progress, along with considerations of how to interpret the pictures were in focus. When leaving therapy the two patients took advantage of the paper, made complete forms, symbolised in words what they have expressed in pictures; in pace with psychotherapy the themes alter towards separation, individuation, and attempt to relate in a new way. The conclusion was that limelimited psychodynamic art therapy suggests giving a safer place for the self as the cohesion is firmer with better boundaries. Study 2 is a pilot study, which involved six young patients newly diagnosed with vulva vestibulitis. The aim of the study was to investigate pain at vestibulum, mental health, and self-image after fifteen sessions of art psychotherapy. Five of the patients were judged to have less pain three months after termination of therapy. The conclusion was that art psychotherapy with its openness seemed to affect young women in their experiences of vulva vestibulitis in a positive direction. Study 3 examined the potential benefit of art therapy for women with primary breast cancer. The sample comprised forty-one (n=41) patients who were randomly assigned either to an art therapy group or to a control group. The art therapy was going on during five weeks radiation treatment, one session per week. The aim was to investigate the outcome of art therapy, to quantify and compare the participant coping s, self-image, and the symptoms with the participant in the control group. Interviews were performed before, immediately after, and six month after inclusion. A set of self-rating scales was used: Coping Resources Inventory, the Structural Analysis of Social Behavior, and Symptom Check List – 90. The result showed that the patients in the art therapy group rated their coping s and especially their social s, higher than the control group, and that the average patients in the art therapy group improved in depressive symptoms and symptoms of anxiety, and that the general psychiatric symptoms improved as well. A linear regression analysis showed a tendency that the coping s increased in the art therapy group and decreased in the control group or even stagnated in the social domain. A second report on self-image, symptoms, treatment, and social variables showed that art therapy was related to lower ratings of depression, anxiety, and general symptoms after treatment; chemotherapeutic treatment predicted lower depressive symptoms and general symptoms in contrast to axilliary surgery and hormonal treatment. The results showed that art therapy could be valuable complementary therapy in routine oncology practise. The conclusion is that art therapy can have a positive long-term effect on the crisis following the primary breast cancer and its consequences. Conclusion: The results show that time-limited psychodynamic art psychotherapy is valuable for depressed women; that it is a valuable complement for women with vulva vestibulitis; and that art therapy is a valuable complement in the care and cure of women with primary breast cancer.

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This diploma paper deals with the data bus line I2C and a supportive demonstration tool for the subject Microprocessor technology taught at the Radioelectronics faculty. The data bus line I2C is convenient when short-distance data transmission with restricted spatial possibilities is required but high velocity of data transmission is not necessary. The tool is compiled in such a way that enables it to also perform other tasks apart from those dealing with the I2C data bus line. The data bus line in the tool is utilized for transmission of date, time, temperature, data for the D/A converter, data from and to the EEPROM memory and data to 16 bits expander.

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Le système hématopoïétique est un tissu en constant renouvellement et les cellules souches hématopoïétiques (CSHs) sont indispensables pour soutenir la production des cellules matures du sang. Deux fonctions définissent les CSHs; la propriété d’auto-renouvellement, soit la capacité de préserver l’identité cellulaire suivant une division, et la multipotence, le potentiel de différenciation permettant de générer toutes les lignées hématopoïétiques. Chez l’adulte, la majorité des CSHs sont quiescentes et l’altération de cet état corrèle avec une diminution du potentiel de reconstitution des CSHs, suggérant que la quiescence protège les fonctions des CSHs. La quiescence est un état réversible et dynamique et les réseaux génétiques le contrôlant restent peu connus. Un nombre croissant d’évidences suggère que si à l’état d’homéostasie il y a une certaine redondance entre les gènes impliqués dans ces réseaux de contrôle, leurs rôles spécifiques sont révélés en situation de stress. La famille des bHLHs (basic helix-loop-helix) inclue différentes classes des protéines dont ceux qui sont tissu-spécifiques comme SCL, et les protéines E, comme E12/E47 et HEB. Certains bHLHs sont proposés êtres important pour la fonction des cellules souches, mais cela ne fait pas l’unanimité, car selon le contexte cellulaire, il y a redondance entre ces facteurs. La question reste donc entière, y a-t-il un rôle redondant entre les bHLHs d’une même classe pour la fonction à long-terme des CSHs? Les travaux présentés dans cette thèse visaient dans un premier temps à explorer le lien encore mal compris entre la quiescence et la fonction des CSHs en mesurant leurs facultés suite à un stress prolifératif intense et dans un deuxième temps, investiguer l’importance et la spécificité de trois gènes pour la fonction des CSHs adultes, soit Scl/Tal1, E2a/Tcf3 et Heb/Tcf12. Pour répondre à ces questions, une approche cellulaire (stress prolifératif) a été combinée avec une approche génétique (invalidation génique). Plus précisément, la résistance des CSHs au stress prolifératif a été étudiée en utilisant deux tests fonctionnels quantitatifs optimisés, soit un traitement basé sur le 5-fluorouracil, une drogue de chimiothérapie, et la transplantation sérielle en nombre limite. Dans la mesure où la fonction d’un réseau génique ne peut être révélée que par une perturbation intrinsèque, trois modèles de souris, i.e. Scl+/-, E2a+/- et Heb+/- ont été utilisés. Ceci a permis de révéler que l’adaptation des CSHs au stress prolifératif et le retour à l’équilibre est strictement contrôlé par les niveaux de Scl, lesquels règlent le métabolisme cellulaire des CSHs en maintenant l’expression de gènes ribosomaux à un niveau basal. D’autre part, bien que les composantes du réseau puissent paraître redondants à l’équilibre, mes travaux montrent qu’en situation de stress prolifératif, les niveaux de Heb restreignent la prolifération excessive des CSHs en induisant la sénescence et que cette fonction ne peut pas être compensée par E2a. En conclusion, les résultats présentés dans cette thèse montrent que les CSHs peuvent tolérer un stress prolifératif intense ainsi que des dommages à l’ADN non-réparés, tout en maintenant leur capacité de reconstituer l’hématopoïèse à long-terme. Cela implique cependant que leur métabolisme revienne au niveau de base, soit celui trouvé à l’état d’homéostasie. Par contre, avec l’augmentation du nombre de division cellulaire les CSHs atteignent éventuellement une limite d’expansion et entrent en sénescence. / The hematopoietic system is constantly replenished by hematopoietic stem cells (HSCs) that are essential to sustain mature blood cells production. Two key functions characterize HSCs; their capabilities to self-renew, i.e. maintenance of cellular identity following cell division, and their multipotencies, i.e. their potentials to generate all hematopoietic lineages. In adults, most HSCs are quiescent and alterations to this state correlate with decreased reconstitution potential, thus suggesting that quiescence protects HSC functions. Quiescence is a reversible and dynamic state, and genetic networks controlling these characteristics are poorly described. Recent evidence suggests that during steady-state hematopoiesis, genes controlling HSC functions are highly redundant, whereas stress conditions may reveal their specific roles. Transcription factors of the basic helix-loop-helix (bHLHs) family include tissue-specific subclasses (e.g SCL) and more ubiquitous E proteins (e.g. E12/E47 and HEB). Several bHLH members have been described as important for HSC functions, however this question is still highly debated in the field due to functional redundancies. How different bHLHs from a same subclass can uniquely affect long term HSC functions is still an open question. The work presented in this thesis aimed to address the question how three bHLH transcription factors specifically Scl/Tal1, E2a/Tcf3 and Heb/Tcf12 control HSC functions after an important proliferative stress to eventually re-establish steady state conditions typified by quiescence in adult HSCs. . To this end, we used three converging approaches, at the cellular level, by imposing a proliferative stress on HSCs, a genetic approach, by deleting genes of interest and genome-wide transcriptomics. More precisely, HSC resistance to proliferative stress has been evaluated under two extreme conditions; i.e. by consecutive treatments with the chemotherapeutic drug 5-fluorouracil (5-FU), mimicking a clinical situation in cancer chemotherapy, and by serial transplantation assays with limited cell numbers. Moreover, to test if a genetic network regulates HSCs functions, we also used three mouse models, i.e. Scl+/-, E2a+/- et Heb+/-. Using these tools, we showed that HSC adaptation to proliferative stress and return to steady state is strictly regulated by Scl expression levels that restricts ribosomal gene expression. Moreover, despite some degree of redundancy within this network, Heb expression levels restrain the excessive proliferation of HSC upon stress conditions by inducing senescence, a function that cannot be compensated for by E2a. To conclude, our results show that HSCs can tolerate both proliferative stress and unrepaired DNA damages without affecting their primary function to replenish the hematopoietic system. This is especially true if their metabolism can come back to basal levels. However, with increased numbers of cell divisions, HSC will sooner or later reach their expansion limit and enter senescence.