To offer customisable software, there are two main concepts yet: software product lines that allow the product customisation based on a fixed set of variability and software ecosystems, allowing an open product customisation based on a common platform. Offering a software family that enables external developers to supply software artefacts means to offer a common platform as part of an ecosystem and to sacrifice variability control. Keeping full variability control means to offer a customisable product as a product line, but without the support for external contributors. This thesis proposes a third concept of variable software: partly open software families. They combine a customisable platform similar to product lines with controlled openness similar to ecosystems. As a major contribution of this thesis a variability modelling concept is proposed which is part of a variability management for these partly open software families. This modelling concept is based on feature models and extends them to support open variability modelling by means of interfaces, structural interface specifications and the inclusion of semantic information. Additionally, the introduction of a rights management allows multiple contributors to work with the model. This is required to enable external developers to use the model for the concrete extension development. The feasibility of the proposed model is evaluated using a prototypically developed modelling tool and by means of a case study based on a car infotainment system.

Submitted by Fabiano Vassallo (fabianovassallo2127@gmail.com) on 2017-05-02T18:14:18Z No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Ana Cristina M Pessoa - Uma experiencia a cançao de Elomar Figueira Mello PDF.pdf: 3144810 bytes, checksum: 7649b6c98e08de4962dee0f8684190df (MD5) / Approved for entry into archive by Josimara Dias Brumatti (bcgdigital@ndc.uff.br) on 2017-05-10T18:50:08Z (GMT) No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Ana Cristina M Pessoa - Uma experiencia a cançao de Elomar Figueira Mello PDF.pdf: 3144810 bytes, checksum: 7649b6c98e08de4962dee0f8684190df (MD5) / Made available in DSpace on 2017-05-10T18:50:08Z (GMT). No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Ana Cristina M Pessoa - Uma experiencia a cançao de Elomar Figueira Mello PDF.pdf: 3144810 bytes, checksum: 7649b6c98e08de4962dee0f8684190df (MD5) / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior / A presente dissertação tem como objeto central a análise do álbum Fantasia leiga para um rio seco (1981), de Elomar Figueira Mello, colocando em diálogo as diferentes linguagens de que é composto — unidades textuais, sonoras e visuais. A fim de realizar a análise crítica da obra, propõe-se uma metodologia que parte da experiência para, então, chegar a discussões mais gerais. Nesse sentido, são utilizadas análises teóricas acerca das noções de experiência, saber de experiência e experiência estética, a partir das quais são realizadas leituras-fruições do álbum. Por meio da perspectiva trazida pelas reflexões teóricas, a leitura-audição é vista como uma oscilação entre efeitos de presença e efeitos de sentido, sensorialidade e cognição, que dependerá sempre de um momento específico de intensidade, de um fruidor, uma memória, um corpo. Desse modo, o conhecimento que se busca em torno de Fantasia leiga é dinâmico, estará sempre entre o legível e o ilegível, não pretendendo, então, recuperar um significado único e estável na obra. Trata-se de um lugar do “entre”, próprio do saber da experiência aqui delimitado, o lugar do indivíduo, do sujeito, do humano. Assim, o saber procurado nesse trabalho se baseia em uma performance específica, um movimento a entrelaçar vibrações de fruidor e obra, desenhando imagens sensoriais e dinâmicas / This work has as its object the analysis of the album Fantasia leiga para um rio seco (1981), of Elomar Figueira Mello, putting in dialogue the different languages that it consists - textual units, sound and visual. In order to achieve a critical analysis of the work, we propose a methodology that begins with experience to then reach more general discussions. Therefore, we use theoretical analyzes and notions about the experience, knowledge of experience and aesthetic experience, from which the albumfruitions readings are held. Through perspective brought by theoretical considerations, the read-hearing is seen as an oscillation between presence effects and effects sense, sensuousness and cognition, which always depend on a specific moment of intensity, a spectator, a memory, a body . Thus, the knowledge that is sought about Fantasia leiga is dynamic, is always among the readable and unreadable, not intending then retrieve a unique and stable meaning. It is the place of "between" and belongs to the knowledge of experience, the place of the individual, the subject, the human. Thus, the knowledge sought in this work is based on a specific performance, a movement to connect vibrations of spectator and work, drawing sensory and dynamic images

L’étude chimique de l’exsudat glutineux recouvrant les bourgeons et la base des feuilles de Gardenia urvillei Montrouz. et Gardenia oudiepe Vieill., Rubiaceae endémiques de Nouvelle-Calédonie, a conduit à la détermination structurale de douze cycloartanes, neuf seco-cycloartanes, huit dammaranes et sept flavonoïdes. Parmi ces métabolites secondaires, six cycloartanes, quatre seco-cycloartanes et deux dammaranes sont des composés originaux. Les évaluations biologiques sur différentes cibles, notamment la recherche de propriétés anti-angiogéniques par déplacement du VEGF de son récepteur VEGF-R1 ou par inhibition de la polymérisation de la tubuline, ayant montré des résultats encourageants, une chimiothèque d’analogues a été hémisynthétisée. A cette fin, les composés majoritaires en séries cycloartane, dammarane, et flavonoïde, respectivement l’oudiépone A, l’hydroxydammarénone II, la santine, la 5,7-dihydroxy-3,3’,4’,5’,6-pentaméthoxyflavone et le kaempférol ont servi de points de départ à des modifications structurales ayant permis d’accéder à douze cycloartanes, deux seco-cycloartanes, trois dammaranes, un seco-dammarane et huit flavonoïdes supplémentaires. Un début de relation structure-activité a ainsi pu être décrit dans les domaines mentionnés précédemment. / Phytochemical studies of glutinous exudate covering the buds et the leaf base of Gardenia urvillei Montrouz. et Gardenia oudiepe Vieill., Rubiaceaeous species endemic to New Caledonia, have led to the identification of twelve cycloartanes, nine seco-cycloartanes, eight dammaranes et seven flavonoids. Among these secondary metabolites, six cycloartanes, four seco-cycloartanes et two dammaranes are original natural products. Biological evaluations, such as search for anti-angiogenic properties or inhibition of tubulin polymerization, have shown promising results. In order to establish the structure-activity relationships for these activities, twenty-six analogs were semisynthesized from the major isolated compounds, oudiépone A, hydroxydammarénone II, santin, 5,7-dihydroxy-3,3’,4’,5’,6-pentamethoxyflavone et kaempferol.

Software Product Lines (SPLs) and Software Ecosystems (SECOs) are approaches to capturing families of closely related software systems in terms of common and variable functionality (variability in space). SPLs and especially SECOs are subject to software evolution to adapt to new or changed requirements resulting in different versions of the software family and its variable assets (variability in time). Both dimensions may be interconnected (e.g., through version incompatibilities) and, thus, have to be handled simultaneously as not all customers upgrade their respective products immediately or completely. However, there currently is no integrated approach allowing variant derivation of features in different version combinations. In this thesis, remedy is provided in the form of an integrated approach making contributions in three areas: (1) As variability model, Hyper-Feature Models (HFMs) and a version-aware constraint language are introduced to conceptually capture variability in time as features and feature versions. (2) As variability realization mechanism, delta modeling is extended for variability in time, and a language creation infrastructure is provided to devise suitable delta languages. (3) For the variant derivation procedure, an automatic version selection mechanism is presented as well as a procedure to derive large parts of the application order for delta modules from the structure of the HFM. The presented integrated approach enables derivation of concrete software systems from an SPL or a SECO where both features and feature versions may be configured.

To offer customisable software, there are two main concepts yet: software product lines that allow the product customisation based on a fixed set of variability and software ecosystems, allowing an open product customisation based on a common platform. Offering a software family that enables external developers to supply software artefacts means to offer a common platform as part of an ecosystem and to sacrifice variability control. Keeping full variability control means to offer a customisable product as a product line, but without the support for external contributors. This thesis proposes a third concept of variable software: partly open software families. They combine a customisable platform similar to product lines with controlled openness similar to ecosystems. As a major contribution of this thesis a variability modelling concept is proposed which is part of a variability management for these partly open software families. This modelling concept is based on feature models and extends them to support open variability modelling by means of interfaces, structural interface specifications and the inclusion of semantic information. Additionally, the introduction of a rights management allows multiple contributors to work with the model. This is required to enable external developers to use the model for the concrete extension development. The feasibility of the proposed model is evaluated using a prototypically developed modelling tool and by means of a case study based on a car infotainment system.

Software Product Lines (SPLs) and Software Ecosystems (SECOs) are approaches to capturing families of closely related software systems in terms of common and variable functionality (variability in space). SPLs and especially SECOs are subject to software evolution to adapt to new or changed requirements resulting in different versions of the software family and its variable assets (variability in time). Both dimensions may be interconnected (e.g., through version incompatibilities) and, thus, have to be handled simultaneously as not all customers upgrade their respective products immediately or completely. However, there currently is no integrated approach allowing variant derivation of features in different version combinations. In this thesis, remedy is provided in the form of an integrated approach making contributions in three areas: (1) As variability model, Hyper-Feature Models (HFMs) and a version-aware constraint language are introduced to conceptually capture variability in time as features and feature versions. (2) As variability realization mechanism, delta modeling is extended for variability in time, and a language creation infrastructure is provided to devise suitable delta languages. (3) For the variant derivation procedure, an automatic version selection mechanism is presented as well as a procedure to derive large parts of the application order for delta modules from the structure of the HFM. The presented integrated approach enables derivation of concrete software systems from an SPL or a SECO where both features and feature versions may be configured.:I. Context and Preliminaries 1. The Configurable TurtleBot Driver as Running Example 1.1. TurtleBot: A Domestic Service Robot 1.2. Configurable Driver Functionality 1.3. Software Realization Artifacts 1.4. Development History of the Driver Software 2. Families of Variable Software Systems 2.1. Variability 2.1.1. Variability in Space and Time 2.1.2. Internal and External Variability 2.2. Manifestations of Configuration Knowledge 2.2.1. Variability Models 2.2.2. Variability Realization Mechanisms 2.2.3. Variability in Realization Assets 2.3. Types of Software Families 2.3.1. Software Product Lines 2.3.2. Software Ecosystems 2.3.3. Comparison of Software Product Lines and Software Ecosystems 3. Fundamental Approaches and Technologies of the Thesis 3.1. Model-Driven Software Development 3.1.1. Metamodeling Levels 3.1.2. Utilizing Models in Generative Approaches 3.1.3. Representation of Languages using Metamodels 3.1.4. Changing the Model-Representation of Artifacts 3.1.5. Suitability of Model-Driven Software Development 3.2. Fundamental Variability Management Techniques of the Thesis 3.2.1. Feature Models as Variability Models 3.2.2. Delta Modeling as Variability Realization Mechanism 3.2.3. Variant Derivation Process of Delta Modeling with Feature Models 3.3. Constraint Satisfaction Problems 3.4. Scope 3.4.1. Problem Statement 3.4.2. Requirements 3.4.3. Assumptions and Boundaries II. Integrated Management of Variability in Space and Time 4. Capturing Variability in Space and Time with Hyper-Feature Models 4.1. Feature Models Cannot Capture Variability in Time 4.2. Formal Definition of Feature Models 4.3. Definition of Hyper-Feature Models 4.4. Creation of Hyper-Feature Model Versions 4.5. Version-Aware Constraints to Represent Version Dependencies and Incompatibilities 4.6. Hyper-Feature Models are a True Extension to Feature Models 4.7. Case Study 4.8. Demarcation from Related Work 4.9. Chapter Summary 5. Creating Delta Languages Suitable for Variability in Space and Time 5.1. Current Delta Languages are not Suitable for Variability in Time 5.2. Software Fault Trees as Example of a Source Language 5.3. Evolution Delta Modules as Manifestation of Variability in Time 5.4. Automating Delta Language Generation 5.4.1. Standard Delta Operations Realize Usual Functionality 5.4.2. Custom Delta Operations Realize Specialized Functionality 5.5. Delta Language Creation Infrastructure 5.5.1. The Common Base Delta Language Provides Shared Functionality for all Delta Languages 5.5.2. Delta Dialects Define Delta Operations for Custom Delta Languages 5.5.3. Custom Delta Languages Enable Variability in Source Languages 5.6. Case Study 5.7. Demarcation from Related Work 5.8. Chapter Summary 6. Deriving Variants with Variability in Space and Time 6.1. Variant Derivation Cannot Handle Variability in Time 6.2. Associating Features and Feature Versions with Delta Modules 6.3. Automatically Select Versions to Ease Configuration 6.4. Application Order and Implicitly Required Delta Modules 6.4.1. Determining Relevant Delta Modules 6.4.2. Forming a Dependency Graph of Delta Modules 6.4.3. Performing a Topological Sorting of Delta Modules 6.5. Generating Variants with Versions of Variable Assets 6.6. Case Study 6.7. Demarcation from Related Work 6.8. Chapter Summary III. Realization and Application 7. Realization as Tool Suite DeltaEcore 7.1. Creating Delta Languages 7.1.1. Shared Base Metamodel 7.1.2. Common Base Delta Language 7.1.3. Delta Dialects 7.2. Specifying a Software Family with Variability in Space and Time 7.2.1. Hyper-Feature Models 7.2.2. Version-Aware Constraints 7.2.3. Delta Modules 7.2.4. Application-Order Constraints 7.2.5. Mapping Models 7.3. Deriving Variants 7.3.1. Creating a Configuration 7.3.2. Collecting Delta Modules 7.3.3. Ordering Delta Modules 7.3.4. Applying Delta Modules 8. Evaluation 8.1. Configurable TurtleBot Driver Software 8.1.1. Variability in Space 8.1.2. Variability in Time 8.1.3. Integrated Management of Variability in Space and Time 8.2. Metamodel Family for Role-Based Modeling and Programming Languages 8.2.1. Variability in Space 8.2.2. Variability in Time 8.2.3. Integrated Management of Variability in Space and Time 8.3. A Software Product Line of Feature Modeling Notations and Constraint Languages 8.3.1. Variability in Space 8.3.2. Variability in Time 8.3.3. Integrated Management of Variability in Space and Time 8.4. Results and Discussion 8.4.1. Results and Discussion of RQ1: Variability Model 8.4.2. Results and Discussion of RQ2: Variability Realization Mechanism 8.4.3. Results and Discussion of RQ3: Variant Derivation Procedure 9. Conclusion 9.1. Discussion 9.1.1. Supported Evolutionary Changes 9.1.2. Conceptual Representation of Variability in Time 9.1.3. Perception of Versions as Incremental 9.1.4. Version Numbering Schemes 9.1.5. Created Delta Languages 9.1.6. Scalability of Approach 9.2. Possible Future Application Areas 9.2.1. Extend to Full Software Ecosystem Feature Model 9.2.2. Model Software Ecosystems 9.2.3. Extract Hyper-Feature Model Versions and Record Delta Modules 9.2.4. Introduce Metaevolution Delta Modules 9.2.5. Support Incremental Reconfiguration 9.2.6. Apply for Evolution Analysis and Planning 9.2.7. Enable Evolution of Variable Safety-Critical Systems 9.3. Contribution 9.3.1. Individual Contributions 9.3.2. Handling Updater Stereotypes IV. Appendix A. Delta Operation Generation Algorithm B. Delta Dialects B.1. Delta Dialect for Java B.2. Delta Dialect for Eclipse Projects B.3. Delta Dialect for DocBook Markup B.4. Delta Dialect for Software Fault Trees B.5. Delta Dialect for Component Fault Diagrams B.6. Delta Dialect for Checklists B.7. Delta Dialect for the Goal Structuring Notation B.8. Delta Dialect for EMF Ecore B.9. Delta Dialect for EMFText Concrete Syntax Files

Orientador: Guilherme de Paula Nogueira / Resumo: O objetivo desse estudo foi comparar as concentrações séricas de cálcio, progesterona e fator de crescimento semelhante à insulina tipo 1 (IGF-I) e a ocorrência de crescimento microbiano no leite e de retenção de placenta antes da secagem e após o parto de vacas de alta produção tratadas ou não com cabergolina. Foram utilizadas 48 vacas multíparas, das raças holandesas, girolandas ou jersolandas no final da lactação (aproximadamente 60 dias antes do parto), com produção acima de 14 L/dia. Os animais foram divididos em grupo controle e grupo tratado, recebendo 5,6 mg de cabergolina via I.M. As coletas de sangue para mensuração das concentrações de progesterona, IGF-I e de cálcio sérico foram realizadas no dia da secagem (antes da aplicação da cabergolina), um dia após a secagem, sete dias após a secagem, de quinze a sete dias antes do parto e sete dias após o parto; no dia do parto e um dia após o parto foi feita apenas a dosagem de cálcio. Para análise microbiológica foi coletado leite sete dias antes da secagem, no dia da secagem e no dia do parto e foi observada a ocorência de retenção de placenta. Não foi observada diferença significativa entre os grupos (p > 0,05) na ocorrência de infecção da glândula mamária, nas concentrações séricas de cálcio e hormônios, exceto nas amostras coletadas uma semana após o parto, quando a concentração de cálcio foi superior no grupo tratado quando comparado ao controle (11,10 ± 1,751 vs. 9,610 ± 2,212 mg/dL, p = 0,03). A ocorrência de rete... (Resumo completo, clicar acesso eletrônico abaixo) / Abstract: The objective of this study was to compare the serum concentrations of calcium, progesterone, insulin-like growth factor-1 (IGF-I), occurrence of milk microbiological growth and of retained placenta before drying off and after parturition in high production dairy cows treated or not with cabergoline. A total of 48 multiparous Holstein, Gyr x Holstein and Jersey x Holstein cows at the end of lactation period (approximately 60 days before partum) were used, with production above 14L/day and sorted into control and treated group receiving 5.6 mg of cabergoline via I.M. Blood samples for serum concentrations of progesterone, IGF-I and calcium were drawn on the day of drying off (before cabergoline injection), one day after drying off, seven days after drying off, between fifteen and seven days before partum and seven days postpartum; on the day of parturition and one day postpartum only calcium was measured. For microbiological analysis, milk samples were collected seven days before drying off, on the day of drying off and on the day of partum. In addition, occurrence of retained placenta were recorded. No significant difference was observed between the groups (p > 0.05) in the occurrence of mammary gland infection, calcium and hormones serum concentrations, except in the samples collected one week after calving, when the calcium concentration was higher in the treated group compared to the control group (11.10 ± 1.751 vs. 9.610 ± 2.212 mg/dL, p = 0.03). The occurrence of placent... (Complete abstract click electronic access below) / Mestre

Este trabalho apresenta o desenvolvimento de uma metodologia experimental visando à produção de extrato seco padronizado de Bauhinia forficata Link. Um planejamento experimental de três fatores e três níveis tipo Box-Behnken e análise multi-resposta foram empregados na otimização do processo de extração. Dois processos distintos de secagem foram investigados: o processo leito de jorro e a secagem por nebulização (ou spray-drying). O objetivo foi avaliar a viabilidade e desempenho de ambos secadores para a produção de extrato seco. As variáveis estudadas foram a razão percentual entre a vazão mássica da solução extrativa alimentada ao sistema pela capacidade de evaporação, (Ws/Wmáx), a temperatura de entrada do gás de secagem, (Tge), a posição do sistema de atomização no leito de jorro (top spray e bottom spray) e a vazão do gás de secagem utilizada no spray-dryer, (Wg). O desempenho operacional dos secadores foi avaliado principalmente através da produtividade, da eficiência térmica do processo, da taxa de evaporação volumétrica, da razão entre a massa de ar usada/massa de água evaporada e da taxa de recuperação do produto. O produto seco foi caracterizado quanto a distribuição granulométrica, morfologia das partículas, teor de umidade residual, taxa de degradação dos flavonóides (marcadores químicos) e características farmacotécnicas. Os resultados reportados mostram que o leito de jorro apresentou significativa superioridade em todos os parâmetros estudados em relação ao processo spray-dryer, para as configurações e condições operacionais investigadas. Isso permite concluir que o secador de leito de jorro é uma alternativa tecnologicamente viável para a produção de extratos secos de plantas medicinais brasileiras apresentando maior eficiência e produtividade, fornecendo um produto de alta qualidade e valor comercial. / This work presents the development of an experimental methodology aiming to the production of standardized dried extracts of Bauhinia forficata Link. An experimental planning of three factors and three levels type Box-Behnken and multi-response analysis were used in the optimization of the extraction process. Two different drying processes were studied: the spouted bed and the spraydrying processes. The objective was the evaluation of the viability and of the performance of both dryers for the production of dry extract. The investigated parameters were the percentile ratio between the mass feed flow rate of extractive solution to the system by the evaporation capacity of the dryer, (Ws/Wmáx), the inlet temperature of the drying gas, (Tge), the position of the atomization system in the spouted bed (top spray and bottom spray) and the mass flow rate of the drying gas used in the spray-dryer, (Wg). The operational performance of the dryers was evaluated mainly by the productivity, thermal efficiency of the process, rate of volumetric evaporation, ratio between the mass of air used by the mass of evaporated water and by the product recovery rate. The dried product was characterized by the particle size distribution, particles morphology, moisture content, flavonoid degradation rate (chemical marker), and by evaluation of pharmacotechnical properties. The results reported show that the spouted bed process presented a significant superiority in all parameters evaluated relative to the spray-drying process, for the configurations and operational conditions investigated. These results lead to the conclusion that the spouted bed process is an alternative technologically viable for the production of dry extracts of medicinal Brazilian plants, presenting high thermal efficiency and productivity, yielding a product of high quality and commercial value.

Alimentos submetidos a processos tecnológicos que requerem altas temperaturas apresentam um grande potencial para a produção de óxidos de colesterol (OsC). Inúmeras evidências indicaram que os óxidos de colesterol são potencialmente citotóxicos, aterogênicos, mutagênicos e carcinogênicos. Em pescados, a oxidação do colesterol está favorecida pela presença de ácidos graxos poliinsaturados e altos níveis de colesterol. O camarão salgado-seco é particularmente suscetível à formação de óxidos de colesterol devido a sua composição lipídica, ao seu processamento e as condições de estocagem. O objetivo deste trabalho foi determinar a ocorrência de produtos da oxidação do colesterol e analisar o perfil lipídico em camarão salgado-seco. Analisou-se cinqüenta amostras de camarão salgado-seco por cromatografia líquida de alta eficiência (HPLC), através da qual foram determinados os teores de óxidos de colesterol. O colesterol e os óxidos de colesterol (7ß-OH, 7?-OH, 7-Ceto e 25-OH) foram analisados simultaneamente. O perfil de ácidos graxos foi determinado por cromatografia gasosa e para a avaliação da oxidação lipídica foi empregado o teste de TBARS. Os resultados indicaram que as amostras examinadas continham: 7ß-OH (34,63-72,56 µg/g), 7?-OH (5,02-12,12 µg/g), 7-Ceto (7,44-32,68 µg/g) e 25-OH (2,37-22,88 µg/g), sendo o 7ß-OH o óxido predominante. A quantidade de (OsC) nas amostras analisadas variou consideravelmente (4,52 a 77,30 µg/g). Quanto ao teor de colesterol total e a concentração média de TBARS, os resultados variaram de 73,88 a 247,69 mg/100g e 0,023 a 1,30 mgMA/Kg respectivamente. O perfil de ácidos graxos encontrado foi de 27,48 % saturados, 43,90% monoiinsaturados e 28,61% poliinsaturados. Este estudo indicou que as amostras estavam oxidadas, tanto pela presença de produtos da oxidação do colesterol como pelos valores de TBARS. Tal oxidação foi, provavelmente, iniciada no processamento e em condições inadequadas de armazenamento. Os resultados reforçaram a importância da reavaliação dos procedimentos que envolvem o manuseio de pescados, particularmente do camarão salgado-seco, desde a captura até a determinação do tempo de prateleira, no sentido de minimizar as reações oxidativas. / Foods submitted to technological processes that require high temperature present a great potential for production of cholesterol oxides (COPs). Several evidences have indicated that COPs are potentially cytotoxic, atherogenic, mutagenic, and carcinogenic. In sea food, the cholesterol oxidation is favored by the presence of unsaturated fatty acids and high cholesterol levels. The salted-dried shrimp is particularly susceptible to the formation of COPs due to its lipidic composition, the processing and storage conditions. The objective of this work was to determine the occurrence of cholesterol oxidation products and to analyze the lipidic profile in salted-dried shrimp. Fifty samples of salted-dried shrimp were evaluated, and the cholesterol oxides were quantified by high-performance liquid chromatography (HPLC). Cholesterol and COPs (7ß-hydroxycholesterol, 7?- hydroxycholesterol, 7-Ketocholesterol and 25- hydroxycholesterol) were simultaneously analyzed. The fatty acids profile was determined by gas chromatography, and for the evaluation of lipidic oxidation the TBARS method was used. The results indicated that the samples contained: 7ß-OH (34.63-72,56 µg/g), 7?-OH (5.02-12.12µg/g), 7-Keto (7.44-32.68 µg/g) and 25-OH (2.37-22.88 µg/g). These data indicated that 7?-OH was the predominant product. The amount of COPs in the samples varied considerably, ranging from 4.52 to 77.30 µg/g. Regarding to the total cholesterol content and the average concentration of TBARS, the results varied from 73.88 to 247.69 mg/100g, and 0.023 to 1.30 mgMA/Kg, respectively. The fatty acids profile was: 27.48% saturated, 43.90% monounsaturated and 28.61% polyunsaturated. This study indicated that the samples were oxidized, by the presence of COPs and the values of TBARS as well. Such oxidation was probably initiated under inadequate conditions of processing and storage. These results reinforced the need of revaluation of the fishing handling procedures, particularly the salted-dried shrimp, including all the stages - from the capture to the de shelf-life determination, in order to minimize the oxidative reactions.

Orientador: Elenice Deffune / Resumo: Introdução: A Síndrome do Olho Seco (SOS) é uma doença multifatorial das lágrimas e da superfície ocular que resulta em desconforto, distúrbios visuais e instabilidade do filme lacrimal e afeta principalmente adultos com mais de 50 anos e mulheres. É uma doença que pode ter grande impacto negativo na qualidade de vida dos pacientes. A abordagem terapêutica com soro autólogo tem sido preconizada desde 1986 com prós e contras na literatura. Esta pesquisa teve como objetivo realizar uma revisão sistemática e metanálise para analisar a efetiva contribuição do Soro Autólogo segundo os protocolos, ensaios terapêuticos publicados nos últimos 10 anos e o atendimento dos pacientes portadores de Síndrome do olho seco (SOS) no Hospital das Clínicas da Faculdade de Medicina de Botucatu .Objetivos: 1) realizar revisão sistemática e metanálise para avaliar a eficácia do uso do soro autólogo em comparação com lágrimas artificiais comerciais no tratamento para adultos com olho seco. 2) realizar um trabalho retrospectivo da contribuição do soro autólogo de uso ocular no tratamento da SOS nos pacientes do ambulatório do Hospital das Clínicas de 2014-2018 comparando com o período anterior (2008-2013). Materiais e Métodos: Para a revisão sistemática e metanálise foi pesquisado na base de dados do Pubmed não usando restrições de língua, apenas trabalhos dos últimos 10 anos. Para os desfechos primários e secundários foi utilizado um intervalo de confiança de 95%. O levantamento de dados dos pacien... (Resumo completo, clicar acesso eletrônico abaixo) / Abstract: Introduction: Dry Eye Syndrome is a multifactorial disease of tears and ocular surface that results into discomfort, visual disturbances and tear film instability and affects mainly female adults, over 50 years. It is a disease which may cause a great negative impact on the patients’ quality of life. The therapeutic approach employing autologous serum has been advocated in 1986, with pros and cons in the literature. This study aimed to perform a systematic review and a meta-analysis to investigate the effective contribution of Autologus Serum according to the protocols and clinical trials published in the last 10 years, and the SOS patients care at Hospital das Clínicas, during two periods: 2008-2013 and 2014- 2018.Objectives: 1) to perform a systematic review and meta-analysis to evaluate the efficacy of the autologous serum, in comparison to commercial artificial tears for the treatment of dry eye in adults. 2) to carry out a retrospective study of the ocular autologous serum contribution for SOS out patients’ treatment, at Hospital das Clínicas (2014 to 2018), comparing with the previous period (2008-2013).Materials and Methods: For the systematic review and meta-analysis, searches were realized in Pubmed databases, with no language restrictions, for papers published in the last 10 years, with full text availability, for researches dated until 10/12/2018. For the primary and secondary outcomes, a 95% confidence interval was used. For the outpatients’ data collection, each ... (Complete abstract click electronic access below) / Mestre