Disaster risk reduction (DRR) is an important strategy for preventing the consequences of climate change. The Sendai Framework states that all countries need to implement national strategies for DRR, which Sweden has not yet done. The scientific problem is partly that there is a lack of research on DRR in welfare countries, and partly that Sweden's municipalities' strategies to control risk reduction are relatively unexplored. The purpose of the paper is therefore to contribute to filling these knowledge gaps, and to map and evaluate Sweden's municipalities' governance work with DRR, to examine whether the municipalities follow the same guidelines or whether the work is carried out completely differently in all municipalities. The study is conducted with a theoretical framework based on the Sendai framework, polycentric governance and disaster risk governance. The method used is qualitative thematic content analysis, where Arjeplog, Gävle, Gothenburg, Helsingborg and Ljusdal's governance documents are analysed based on the theoretical framework. The results showed that the five municipalities internally govern DRR relatively well, where the main shortcoming, however, is that no municipality uses DRR as a concept. The conclusions are therefore that municipalities need to include DRR more in their governance documents, to make beneficial and deficient factors visible. Governance between municipalities and at different levels is also in need of further development and research.

京都大学 / 新制・課程博士 / 博士(医学) / 甲第23812号 / 医博第4858号 / 新制||医||1059(附属図書館) / 京都大学大学院医学研究科医学専攻 / (主査)教授 金子 新, 教授 山下 潤, 教授 朝長 啓造 / 学位規則第4条第1項該当 / Doctor of Medical Science / Kyoto University / DFAM

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Le Saccharopolyspora rectivirgula (SR) est le principal agent responsable du Poumon du fermier, une forme d'alvéolite allergique extrinsèque. Des modèles expérimentaux ont permis de mieux comprendre cette maladie qui est caractérisée par une réponse immune exacerbée et une lymphocytose pulmonaire marquée. Des cofacteurs, tels l'infection virale, sont probablement nécessaires au développement de la maladie puisque la majorité des sujets exposés demeurent asymptomatiques. Par contre, les mécanismes expliquant le maintient de la tolérance à l'antigène chez ces individus ou le développement de la maladie chez les patients sont inconnus. L'objectif premier de ce projet de doctorat était donc d'examiner le rôle potentiel des cellules T régulatrices (Trég) dans le contrôle de la réponse immune dans l'alvéolite chez la souris et chez l'humain. Chez la souris, nos résultats démontrent que, des expositions répétées à une préparation antigénique de SR induisent des Trég capables de supprimer la prolifération de cellules T activées. Des données similaires ont été obtenues chez les sujets asymptomatiques ce qui pourrait expliquer la réponse tolérante retrouvée chez ces individus. Notre modèle murin démontre également qu'une infection virale altère cette tolérance à l'antigène. À la suite d'une infection au virus Sendai, les Trég ne peuvent inhiber la prolifération de cellules T activées et ne contrôlent plus l'inflammation causée par des expositions subséquentes au SR. Des Trég non-fonctionnelles sont également observées chez les patients. Au cours de nos recherches, nous avons remarqué que la stimulation de la réponse immune par un lysat de SR protège contre une infection mortelle au virus Sendai. Nous avons caractérisé cet effet antiviral et démontré qu'une seule instillation d'une préparation antigénique de SR (200 pg) administrée de 24 à 120 heures avant l'infection virale protège efficacement le système pulmonaire en diminuant le nombre de cellules inflammatoires. Cette protection est efficace pendant une semaine. Cette thèse a donc permis de constater que l'inhalation de SR, selon l'historique des expositions et des co-infections, peut soit induire l'alvéolite ou générée une protection efficace contre l'infection virale.

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In 2020, the world and foremost vulnerable groups are facing “new” challenges. Dual crises of coexisting hazards like natural hazards occurring amid the COVID-19 pandemic has become more than a prediction. Hence, this thesis is a case study of dual crises and of how organisations and actors act upon those crises. With the aim to examine how the United Nations Office for Disaster Risk Reduction (UNDRR) includes vulnerable groups in disaster risk reduction related matters amid the COVID-19 pandemic, a qualitative text analysis has been performed on the selection of five of UNDRR’s publications. Developed from the Sendai Framework for Disaster Risk Reduction’s four ‘Priorities for Action’ guidelines, four analytical questions were asked to the material. The findings suggest that UNDRR does include vulnerable groups by mainly addressing the lack of resilience among vulnerable groups. However, a lack of concrete suggestions on how to strengthen vulnerable groups resilience and effective responses in the long term was noted. Due to the short time frame in which COVID-19 has existed, the research on vulnerable groups in dual crises of various hazards are still scarce, but nevertheless very much needed as to develop responses adapted towards both biological hazard and natural hazard impacts.

Occurrences of extreme weather events are increasing due to the ongoing climate change driven by human actions. In parallel, this triggers a growing need for humanitarian action in the future to help those impacted by disasters. Disaster risk reduction and management has hereby become a central element of today's national and global governance in the aim of preventing and reducing humanitarian crises and minimizing economic loss often resulting from the impacts of natural hazards. The now more global effects from these events has resulted in a collective vision that is constantly concerned with the future and how to reduce the disaster risks it withholds. Due to climate change and a great number of other risks to our societies having been generated through humanity’s own actions, the possible indication of the global society attempting to gain control over uncontrollable risks through collective disaster risk reduction strategies between countries draws attention. This thesis provides a qualitative content analysis of the Sendai Framework for Disaster Risk Reduction 2015-2030, which is the most current international disaster risk reduction policy adopted by the United Nations. The risk society theory by German sociologist Ulrich Beck is applied to this study to examine how the Sendai Framework can be seen as an outcome of a risk society that attempts to gain control over risks from the natural environment, which can be perceived as uncontrollable. The results of this study uncover that the Sendai Framework can be regarded as a product of a risk society through several different aspects, and that it generates an illusion of gaining control over uncontrollable risks.

Die für die Vermehrung der Paramyxoviren notwendige Freisetzung des Virusgenoms in die Wirtszelle findet nach einer Verschmelzung der Virushülle mit der Zellmembran statt. Die Membranfusion wird durch eine Konformationsänderung des membranständigen Fusionsproteins (F-Protein) der Paramyxoviren vermittelt. Der Auslöser der Strukturumwandlung des F-Proteins ist bislang unbekannt. Man nimmt an, daß eine Wechselwirkung mit dem zweiten membranständigen Protein der Hämagglutinin-Neuraminidase (HN-Protein) die Strukturumwandlung des F-Proteins induziert. Das F-Protein kann jedoch auch in Abwesenheit des HN-Proteins eine Membranfusion vermitteln. Für das Verständnis des Mechanismus der F-proteinvermittelten Fusion ist die Kenntnis der dreidimensionalen Struktur des F-Proteins notwendig. In der vorliegenden Arbeit wurden die F-Proteine der Paramyxoviren, Sendaivirus und Simianvirus 5, in fusionskompetenter Form isoliert und in kleine Lipidvesikel rekonstituiert, um deren Struktur mittels Kryoelektronenmikroskopie und Einzelpartikelanalyse aufzuklären. Die 3D-Struktur des Sendaivirus-F-Proteins konnte mit einer Auflösung von 16 Angström aufgeklärt werden. Es ist die erste 3D-Struktur des F-Proteins eines Paramyxovirus in der fusionskompetenten Form. Um geeignete Bedingungen herauszufinden, die das Auslösen der Konformationsänderung der F-Proteine bzw. das "Einfangen" von Strukturintermediaten während der Fusion ermöglichen, wurde das Fusionsverhalten von Sendaivirus und Simianvirus 5 bei unterschiedlichen Temperatur- und pH-Werten sowie in Anwesenheit von Lysolipiden mittels Fluoreszenzdequenchingassays untersucht. Ein signifikanter Anstieg der Fusionsaktivität der untersuchten Viren konnte durch eine Erhöhung der Temperatur erreicht werden. Mittels ESR-Spektroskopie unter Einsatz von spinmarkierten Lysolipiden konnte gezeigt werden, daß Lysolipide die proteinvermittelte Fusion von Hüllviren in einem späten lipidabhängigen Schritt hemmen. Diese Untersuchungen bilden damit eine Grundlage zur Aufklärung der 3D-Struktur des F-Proteins im fusionsaktiven Zustand. Desweiteren wurde die Rolle der transmembranalen und zytoplasmatischen Domäne des F-Proteins bei der Membranfusion und der Wechselwirkung mit dem HN-Protein mittels Fluoreszenzmikroskopie untersucht. Die Befunde der 3D-Strukturaufklärung und der fluoreszenzmikroskopischen Studien wurden unter anderem in Hinblick auf die Bedeutung der Wechselwirkung zwischen den F- und HN-Proteinen für die Fusion diskutiert. / Paramyxoviruses infect their host cells by fusion of the viral envelope with the cell membrane. The membrane fusion is mediated by a confomational change of a viral envelope glycoprotein called the fusion (F) protein. The trigger of the F protein conformational change is still unknown. It is suggested, that an interaction of the F protein with the second envelope glycoprotein hemagglutinin-neuraminase (HN) induces its conformational change. However the F protein can mediate membrane fusion in absense of HN. The knowledge of the three dimensional structure of the F protein is reqiured to understand the F mediated membrane fusion. In the present work the fusion competent form of the fusion proteins of the paramyxoviruses Sendai virus and Simian virus 5 were isolated and incorporated each of them into small lipid vesicles. The 3D-structure of the entire ectodomain of the Sendai virus F protein has been determined in fusion potential conformation by cryo electron microscopy of single molecules and 3D-reconstruction at a resolution of 16 Angström. To detect usefull conditions for triggering the conformational change of F, the fusion of Sendai virus and Simian virus 5 have been studied at different temperature and pH, respectively, using a fluorescence dequenching assay. A significant increase of virus fusion activity has been found due to temperature enhancement. Using ESR-spectroscopy and spin-labeled lysolipids it has been shown that lysolipids inhibit the protein mediated fusion of enveloped viruses at a late lipid-dependent intermediate. Thus lysolipids are capable to freeze a conformational intermediate of the F protein during fusion. Furthermore the role of the transmembrane and the cytoplasmic domain of the Sendai virus F protein for membrane fusion was investigated using fluorescence microscopy. The results of the fluorescence microscopy study and the detection of the 3D-structure have been discussed in view of the relevance of F-HN-interaction for membrane fusion.

In this thesis I offer a brief overview of the current legislative, regulatory and treaty frameworks impacting emergency management in British Columbia, with a particular emphasis on Crown-identified First Nation roles. I show that the regime overwhelmingly positions non-First Nation governments, contractors and other organizations to manage emergencies on behalf of First Nations. I explore emergency management as a manifold process that includes protracted planning, mitigation and recovery phases, which, unlike emergency response, are carried out with lower levels of urgency. I consider Canadian Constitution Act, 1982 (s. 35) Aboriginal rights in light of the lack of statutorily prescribed inclusion of First Nations in off-reserve emergency management, particularly at the planning, mitigation and recovery phases concluding that the jurisprudence to date (including the duty to consult and Aboriginal title) does not appear to have revolutionized the regime. While the constitutional status of Aboriginal rights should operate to insure adequate First Nation direction in each stage of emergency management, the regime continues to restrictively prioritize other constitutional priorities, such as division of powers and civil liberties. To better understand the omission, I theorize the lack of Crown implementation of s. 35 Aboriginal rights generally as an ‘obligation gap’, highlighting how an analysis of s. 35 Aboriginal rights as ‘negative rights’ fails to compel implementation of the full scope of Crown obligations implicit within the jurisprudence to date. I then offer a new framework for s. 35 as justiciable ‘recognition rights’ and juxtapose ‘recognition rights’ with the idea of justiciability of government inaction through a brief comparative analysis of socioeconomic rights in South Africa’s constitution and Canada’s constitutional Aboriginal rights. With a decided emphasis on the obligations of the Crown, this thesis attempts to offer fodder to First Nations and legal practitioners seeking to challenge the emergency management landscape where First Nations seek an enhanced role in protecting and restoring their respective territories in anticipation of, and in the wake of, disaster. For convenience and clarity, contemporary geographical and jurisdictional references to the areas now known as Canada and British Columbia are used throughout the thesis without intention to detract from the integrity of First Nation claims to their traditional and ancestral territories.

While early relocation is not makeable, disaster risk reduction seems to be the most effective tool to decrease the impact of a disaster. This case study focuses on three UNDRR frameworks as they appear to be the greatest instance of international documents referring to disaster risk reduction (DRR). Especially, this research examines the representation of women within these frameworks and how their portrayal in DRR has changed over the last two decades. To do so, a critical discourse analysis of the three UNDRR frameworks is conducted. This study benefits from a social vulnerability approach and further engages with the Feminist Political Ecology theory. The analysis finds that even though women are increasingly represented in the frameworks, their roles as active participants remain negligible. Their knowledge and interest are still not recognised as valuable in DRR. Rather, women seem to be employed as tools to include more gender-sensitive programmes. This study recommends a greater and more complex emphasis on women in future DRR policies.