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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
91

Olfactory communicatiaon : chemical characterization of the interdigital secretion of the black wildebeest, Connochaetes gnou

Slade, Desmond 12 1900 (has links)
Thesis (PhD)--Stellenbosch University, 2000. / ENGLISH ABSTRACT: The black wildebeest, Connochaetes gnou, is a terriorial animal and although it is not generally accepted, it is believed that it defines its territory by scent marking, using interdigital and preorbital secretions, faeces, and urine. The aim of this study was to characterize the chemical constituents of the interdigital secretion. Due to the complexity of the secretion, only one hundred and ten of the approximately 350 compounds could be determined with known techniques. Gas chromatography, low resolution GC-MS and retention-time comparison were the main analytical techniques used. Classes of compounds identified in the interdigital secretion include the following: • Hydrocarbons - Aliphatic (saturated and unsaturated) and aromatic • Alcohols - Aliphatic (saturated, unsaturated, cyclic and diols) • Phenols and Phenylalkanols • Aldehydes - Aliphatic (saturated and unsaturated) and aromatic • Ketones - Aliphatic (saturated, unsaturated, cyclic and diketones) and aromatic • Hydroxy ketones - Aliphatic and cyclic • Carboxylic acids - Aliphatic (saturated, unsaturated and cyclic) and aromatic • An anhydride • Esters - Methyl esters, ethyl and higher esters, unsaturated esters and aromatic esters • Lactams • A steroid Only small qualitative and quantitative differences were found between the male and female interdigital secretions. / AFRIKAANSE OPSOMMING: Die swartwildebees, Connochaetes gnou, is 'n territoriale dier en alhoewel dit nie algemeen aanvaar word nie, word vermoed dat hierdie bokke hul gebied afbaken met behulp van interdigitale en preorbitale afskeidings, en deur faeces en urine. Die doel van hierdie studie was om die chemiese samestelling van die interdigitale afskeiding te karakteriseer. As gevolg van die kompleksiteit van die afskeiding, kon slegs eenhonderd-en-tien van die ongeveer 350 verbindings met bekende bestaande tegnieke geïdentifiseer word. Gaschromatografie, lae resolusie GC-MS en retensietyd-vergelyking was die belangrikste analitiese tegnieke wat gebruik is. Klasse van verbindings wat bepaal is, sluit die volgende in: • Koolwaterstowwe - Alifaties (versadig en onversadig) en aromaties • Alkohole - Alifaties (versadig, onversadig, siklies en diole) • Fenole en Fenielalkanole • Aldehiede - Alifaties (versadig en onversadig) en aromaties • Ketone - Alifaties (versadig, onversadig, siklies en diketone) en aromaties • Hidroksiketone - Alifaties en siklies • Karboksielsure - Alifaties (versadig, onversadig en siklies) en aromaties • 'n Anhidried • Esters - Metiel esters, etiel en hoër esters, onversadigde esters en aromatiese esters • Laktame • 'n Steroïed Slegs klein kwalitatiewe en kwantitatiewe verskille is gevind tussen die bul en koei interdigitale afskeidings.
92

Sinnesstämningens inflytande på olfaktorisk perception / How olfactory perception is influenced by mood

Popucza, Tímea Zsuzsanna January 2017 (has links)
De flesta forskare inom området är överens om att det finns kopplingar mellan luktsinnet och känslor. Däremot finns det mindre forskning och bevis kring hur människors inre tillstånd påverkar olfaktorisk perception, dvs. uppfattningen av dofter. Föreliggande studie hade avsikt att studera sambandet mellan sinnesstämning och uppskattning av behagliga dofter. Den aktuella sinnesstämningen mättes med hjälp av Mood Adjective Checklist (Sjöberg et.al., 1979), ett tillförlitligt och känsligt instrument. För att mäta doftuppskattning användes fem olika dofter på doftstickor. Dofterna valdes ut systematiskt, testades i förväg och bekräftades som behagliga. Resultaten kunde inte visa något signifikant samband mellan sinnesstämning och doftuppskattning (p = .612). Ingen predicerande effekt i sinnesstämning och i de olika dimensionerna av sinnesstämningen på doftuppskattning kunde påvisas (p varierar mellan .293 och .862). Resultaten kan ha påverkats av metodologiska brister och utformningen av dofttestningsinstrumentet som diskuterats.
93

[en] PRIORITIZATION OF CODE ANOMALIES BASED ON ARCHITECTURE SENSITIVENESS / [pt] PRIORIZAÇÃO DE ANOMALIAS DE CÓDIGO SENSÍVEL A ARQUITETURA

ROBERTA LOPES ARCOVERDE 30 January 2015 (has links)
[pt] Um dos principais sintomas de declínio da qualidade arquitetural em projetos de software é a manifestação contínua de anomalias de código. Quando estas anomalias não são detectadas e removidas com antecedência, a capacidade de evoluir e manter estes sistemas pode ser comprometida, e, eventualmente, uma reestruturação completa de suas arquiteturas é inevitável. Apesar da existência de diversas técnicas e ferramentas para detecção automática de anomalias de código, a identificação de anomalias que efetivamente causam problemas arquiteturais é ainda uma tarefa desafiadora e não trivial. Ademais, estudos realizados no contexto desta dissertação ostraram que desenvolvedores tendem a refatorar mais frequentemente anomalias que não causam problemas arquiteturais. Em especial, percebeu-se que desenvolvedores priorizam a refatoração de elementos de código que não afetam a arquitetura dos sistemas, como métodos privados ou módulos internos de um componente arquitetural. Neste contexto, o presente trabalho propõe uma abordagem para priorização de anomalias de código. Esta abordagem é composta por heurísticas que exploram diferentes fatores para identificar e ordenar as anomalias detectadas de acordo com suas relevâncias arquiteturais. Tais fatores compreendem desde a quantidade de mudanças realizadas no código ao longo da evolução dos sistemas, até os papéis arquiteturais por ele desempenhados. Foi ainda implementada uma ferramenta para aplicar tais heurísticas de priorização automaticamente em projetos Java. A abordagem proposta foi avaliada em 4 projetos de software de diferentes domínios. Tal avaliação revelou que mantenedores de software poderiam ser beneficiados pelas recomendações de priorização produzidas pela ferramenta, de modo a investir seus esforços de refatoração na solução de problemas arquiteturalmente relevantes. / [en] The progressive manifestation of code anomalies in a software system is a key symptom of its architecture quality decline. When those anomalies are not detected and removed early, the maintainability of software projects can be compromised irreversibly, and, eventually, a complete redesign is inevitable. Despite the existence of many techniques and tools for code anomaly detection, identifying anomalies that are more likely to cause architecture problems remains a challenging task. In fact, studies performed in the context of this dissertation show that even when there is tool upport for detecting code anomalies, developers seem to invest more time refactoring those that are not related to architectural problems. Moreover, we also found that developers frequently prioritize refactoring of code elements that do not contribute to a better adherence to the intended software architecture. In this context, this dissertation proposes a prioritization approach for identifying which anomalies in a system implementation are more harmful to the architecture. The proposed approach is composed of heuristic strategies that exploit several software project factors to identify and rank code anomalies by their architecture relevance. These factors range from the change characteristics to the potential architecture roles of software modules. Furthermore, we implemented tool support for applying our prioritization approach in Java projects. We also evaluated the prioritization approach on 4 software projects from different application domains. Our evaluation revealed that software maintainers could benefit from the recommended rankings for identifying which code anomalies are harming architecture the most, helping them investing their refactoring efforts into solving the architecturally relevant problems.
94

Avaliação do olfato em pacientes com doença de Wilson / Smell analysis in patients with Wilson\'s disease

Carvalho, Margarete de Jesus 21 January 2016 (has links)
A Doença de Wilson (DW) é uma moléstia hereditária, caracterizada pela deficiência de excreção do cobre pelo fígado devido à mutação do gene A TP7B. O distúrbio do olfato ocorre com frequência em doenças neurodegenerativas como na doença de Parkinson (DP) e na doença de Alzheimer (DA). A análise do olfato tem sido utilizada como um instrumento útil no diagnóstico diferencial das diversas formas de parkinsonismo degenerativo, e, especialmente, na diferenciação entre DP e tremor essencial. O diagnóstico precoce na DW é a chave para o sucesso do tratamento. Na hipótese de haver comprometimento do olfato em fases iniciais da doença, esse poderia ser um dado a mais para auxiliar no diagnóstico. Até o presente, há apenas um estudo relacionando a DW com a disfunção do olfato. O objetivo deste estudo foi avaliar o olfato em um grupo de pacientes com DW e confrontar com grupo- controle. No presente estudo, foram analisados 37 portadores de DW com manifestação neurológica, 24 portadores de DW sem manifestação neurológica e 59 controles. Todos os indivíduos foram analisados com relação à idade, ao gênero, ao grau de escolaridade, ao uso de tabaco e ao miniexame do estado mental (MEEM), e os portadores de DW foram avaliados quanto ao tempo de doença, tratamento medicamentoso e escore neurológico. O olfato foi avaliado por meio do teste de identificação de odor 8niffin\' 8ticks (88-16 canetas numeradas e quatro opções de resposta para cada uma). Vinte e quatro indivíduos eram pacientes da DW sem manifestação neurológica (45,83% do gênero feminino) e 37 pacientes apresentavam manifestações neurológicas (56,76% do gênero masculino). O qrupo-controle foi composto por 59 indivíduos, 35 (59,33%) do gênero masculino. As médias de- idade foram de 33,38 ± 9,79 anos no grupo de portadores de DW com manifestação neurológica; 29 ± 9,61 anos no grupo de portadores de DW sem manifestação neurológica e 33,81 ± 10,67 anos no grupo-controle. Todos os pacientes com DW estavam em tratamento: 47(77%) com penicilamina, 7 (11,5%) com trientine e 7 (11,5%) com sais de zinco. As médias de respostas corretas no teste de identificação do odor 88-16 foram: 12,03 ± 2, 21 no grupo de portadores de DW com manifestação neurológica, 12, 15 ± 2,07 no grupo de portadores de DW com manifestação hepática e 12,70 ± 2,03 para o grupo- controle. Na avaliação objetiva do olfato com o teste de identificação do odor SS-16, não foi evidenciada diferença significativa entre os três grupos analisados, mas observou-se que o MEEM e o grau de escolaridade influenciaram significativamente no escore do 88-16 na comparação do grupo de pacientes com DW com manifestação neurológica com os outros dois grupos (grupo-controle e o grupo de portadores de DW com manifestação hepática). No presente estudo, não foi evidenciada disfunção olfatória nos pacientes com DW, mas foi observada diminuição da percepção do olfato em alguns pacientes com DW (com e sem manifestação neurológica). Em relação à disfunção olfatória evidenciada em alguns pacientes com DW na presente análise, algumas considerações são pertinentes e poderiam ter influenciado na identificação do olfato neste grupo de pacientes com DW. O acúmulo de cobre e a produção de radicais livres no sistema nervoso central (SNC) podem desencadear processos de neurodegeneração em estruturas envolvidas no olfato, alterações metabólicas, acúmulo de substâncias neurotóxicas (amônia e manganês) e alterações de neurotransmissores, e contribuir para o surgimento da disfunção olfatória / Wilson\'s disease (WO) is a hereditary disease due to a mutation in ATP7B gene, characterized by deficiency of copper excretion by the liver. Smell disorders are frequently encountered in neurodegenerative diseases, such as Parkinson\'s disease (PO) and Alzheimer\'s disease (AO). Smell analysis has been a useful tool for the differential diagnosis of several forms of degenerative parkinsonism, and especially for the differentiation between PO and essential tremor. Early diagnosis in WO is the key for a successful treatment. If there were smell impairment in the early stages of the illness, it could be used as another clue to help on its diagnosis. To the present date, there is only one study connecting WO with smell problems, the aim of this study was to evaluate smell function in a group of WO patients and compare them with a control group. We analyzed 37 WO patients with and 24 WO patients without neurologic symptoms, and 59 controls. Ali subjects were evaluated regarding age, gender, schooling, tobacco use, Mini Mental State Examination (MMSE), and the WO patients were also evaluated regarding duration of the illness, medication and neurologic scoring. Smell was analyzed by means of Sniffin\' Sticks smell identification test (SS-16 numbered pens and four options of answer for each pen). Twenty-four subjects with WO had no neurologic symptoms (45.83% female), and 37 patients had neurologic impairment (56,76% male). The control group was composed by 59 individuais, 35 (59,33%) male. Their age average were 33,38 ± 9,79 years for WO neurologic symptoms; 29 ± 9,61 years for WO without neurologic symptoms; and 33,81 ± 10,67 years for the control group. Ali WO patients were on treatment: 47(77%) with penicillamine, 7(11,5%) with trientine, and 7(11,5%) with zinc salt formulations. The average of correct answers in the SS-16 were: 12,03 ± 2,21 for the WO with neurologic symptoms group; 12,15 ± 2,07 for the WO without neurologic symptoms; and 12,70 ± 2,03 for the control group. In the smell testing with SS-16, there was no significant difference among the three groups, but the MMSE scoring and schooling had a significant influence over SS-16 score when comparing WO with neurologic symptoms patients with the other groups (WO patients without neurologic symptoms and control group). There was no smell dysfunction in WO patients in this study, but diminished smell perception was observed in some WO patients (either with or without neurologic impairment). Regarding smell impairment observed in some WO patients in the current analysis, some considerations must be made that could have influenced smell identification in these individuais. Copper accumulation and free radicais production in the central neNOUS system can trigger neurodegeneration processes in structures involved in srnell perception, metabolic impairment, building up of neurotoxic substances (such as ammonia and manganese), and neurotransmitter disorders, contributing to the emergence of srnell dysfunction
95

Odor processing and associative olfactory learning in the moth Manduca sexta. / 烟草天蛾嗅覺系統運作及氣味學習的原理研究 / CUHK electronic theses & dissertations collection / Yan cao tian e xiu jue xi tong yun zuo ji qi wei xue xi de yuan li yan jiu

January 2010 (has links)
Neural representations of odors get associated with other stimuli through experience. Are action potentials the neural representation that directly gets associated with reinforcement during conditioning? In Manduca , I found that odor presentations elicited only one or two spikes at odor onset (and sometimes offset) in each of a small portion of Kenyon cells, a population of neurons known to be crucial for olfactory associative learning. By using a series of odor-taste associative conditioning paradigms with various sucrose presentation timings, I carefully controlled the temporal overlap between Kenyon cell spiking and sucrose reinforcement timing. I found that in paradigms that led to learning, spiking in Kenyon cells ended well before the reinforcement was given. Further, increasing the temporal overlap between Kenyon cell spiking and sucrose reinforcement actually reduced learning efficacy. Therefore, spikes in Kenyon cells are not the neural representation that gets directly reinforced, and Hebbian spike timing--dependent plasticity in Kenyon cells alone cannot underlie this learning. / Two important focuses in neuroscience are to study how animals process sensory stimuli, and how such stimuli get associated with other sensory modalities through experience. Often, sensory stimuli elicit the oscillatory synchronization of neurons in different parts of the brain, and thus may constitute an important stage in sensory processing. Odor-evoked oscillatory synchronization has been observed in a wide variety of animals, including mammals and insects. Despite differences in details of anatomical structure, animals from widely different phyla appear to use similar strategies to encode odors. Here, using the moth Manduca sexta, I examined the factors that cause odor-evoked oscillatory synchronization of olfactory neurons and that determine the frequency of these oscillations. I found that frequency of oscillations decreased from ∼40 Hz to ∼20 Hz during the course of a lengthy odor pulse. This decrease in oscillatory frequency appeared in parallel with a decrease in net olfactory receptor output, suggesting that the intensity of olfactory receptor neuron input to the antennal lobe, the first olfactory relay center, may determine oscillatory frequency. However, I found that changing odor concentration had little effect on oscillatory frequency. Combining the results of recordings made in vivo and computational models, I found that increasing odor concentration recruited additional, but less well-tuned olfactory receptor neurons to respond to the odor. Firing rates of these neurons were tightly constrained by adaptation and saturation. My work established that, in the periphery, odor concentration is mainly encoded by the size of the olfactory receptor neuron population that responded to the odor, whereas oscillatory frequency is determined by the adaptation and saturation of this response. / Ong, Chik Ying Rose. / Advisers: Siu Kai Kong; Mark Stopfer. / Source: Dissertation Abstracts International, Volume: 72-04, Section: B, page: . / Thesis (Ph.D.)--Chinese University of Hong Kong, 2010. / Includes bibliographical references (leaves 132-147). / Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web. / Electronic reproduction. Ann Arbor, MI : ProQuest Information and Learning Company, [200-] System requirements: Adobe Acrobat Reader. Available via World Wide Web. / Abstract also in Chinese.
96

La muséologie olfactive, une actualisation résonante de la muséalité de Stránský par l'odorat / The olfactory museology, a resonant actualization of museality through the sense of smell

Castel, Mathilde 05 July 2019 (has links)
A l’instar d’autres médiums, la muséologie permet de rendre compte d’une manière dont l’homme s’approprie spécifiquement la réalité. Cette dernière consiste à y sélectionner des objets, à les prélever, puis à les agencer dans le cadre d’expérience que constitue le musée afin de créer ce que l’on appelle une réalité muséalisée : addition de savoirs contenus dans les objets, manifestés par l’exposition, puis proposés à l’acquisition par l’intermédiaire de sa visite. Cette relation spécifique de l’homme à la réalité est appelée muséalité et telle que ci-dessus relatée, renvoie aux travaux du muséologue Zbynĕk Zbyslav Stránský pour qui la collection d’objets revêt une place centrale au sein du système muséal. Mais à l’heure du numérique connecté et de la possibilité que nous avons de voir les éléments de la réalité sans se trouver physiquement en leur présence, l’importance accordée à la collection d’objets par Stránský semble rendre sa conception de la muséalité obsolète à penser la muséologie. Prenant par conséquent appui sur les travaux du sociologue et philosophe Hartmut Rosa, et notamment sur leur désignation du rôle joué par la perception olfactive dans la qualité de notre relation au monde, la présente recherche s’attache à démontrer que si inadéquation il y a entre les théories de Stránský et l’actualité de l’appropriation de la réalité par l’homme, elle n’incombe pas tant à la dimension physique des objets de musées, qu’à la mono-sensorialité des moyens dont il nous est permis de les entretenir. Alliant la théorie à la pratique, ce travail argumente le fait qu’actualisé au prisme du concept de résonance proposé par Rosa, les travaux de Stránský jouissent encore d’une légitimité à penser les muséologies d’aujourd’hui et de demain. / Like other mediums, museology shows a way in which man specifically appropriates reality. It consists in selecting objects from it, taking them out and arranging them in the museum's experimental setting in order to create what is called a musealized reality: addition of knowledge contained in objects, manifested by the exhibition, and offered for acquisition through the visit. This specific relation of man to reality is called museality and as mentioned above, refers to the work of the museologist Zbynĕk Zbyslav Stránský for whom the collection of objects is central to the museum system.But in the age of digital and the possibility that we have to see the elements of reality without being physically with them, the importance given to the collection of objects by Stránský seems to make his conception of museality obsolete to think museology.Taking as a result the work of the sociologist and philosopher Hartmut Rosa, and in particular his designation of the role played by olfactory perception in the quality of our relationship with the world, the present research endeavors to demonstrate that if there is a mismatch between Stránský's theories and the actuality of the appropriation of reality by man, it is not so much because of the physical dimension of museum objects than the mono-sensoriality of the means of which we are allowed to maintain them. Combining theory with practice, this work argues that, updated by the concept of resonance proposed by Rosa, Stránský's works still have a legitimacy to think about museologies of today and tomorrow.
97

Scent Marketing: What is the impact on stores in Umeå?

Blondeau, Mathieu, Tran, Amélie January 2009 (has links)
<p><!--[if gte mso 10]> <mce:style><! /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Tableau Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin-top:0cm; mso-para-margin-right:0cm; mso-para-margin-bottom:10.0pt; mso-para-margin-left:0cm; text-align:justify; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin;} > <! [endif] ></p><p>The way of consumption has changed. Now, consumers are not only rational when purchasing. They do not buy just for the functionality of the good or service they are looking for. The consumption is more affective and consumers are considered now as poly-sensorial entities that are looking for more emotional and sensorial stimulation during their purchase process. This evolution of consumption is part of the trend that is called "retailtainnment", a mixed of "Retail" and "Entertainment". It is a concept of distribution that combines both of those two activities. Earlier studies have shown the success of using the Sensory Marketing, a concept based on stimulating the five senses in a strategy view. But, if certain senses are heavily used by companies/brands, as the sight and hearing, some are still underused, as the touch, the taste and particularly the smell. Wherefore a study on scent marketing is considered relevant to measure the potential of it. Even if several studies have already explained the important role of smell in a company's strategy, only few of them are using it. Our paper aims to go further on this subject by understanding the scent marketing in stores through the aims, the obstacles, the techniques used, in Umeå, Sweden.</p><p> </p><p>For our research, we first had to collect knowledge from scientific articles and previous studies on odours, on smells or perfumes and on scent marketing. Then, we constructed three hypothesises that helped us to conduct our research and made conclusions. Those hypotheses will be discussed by conducting a mixed-method, that is to say by combining two types of researches: a quantitative one, mainly to measure how many stores are using smell as a marketing tool, and then a qualitative one to go deeper into the reasons and how those stores are applying it. The quantitative research, based on a deductive approach, was conducted by using questionnaires. The qualitative research, based on an inductive approach was conducted by making semi-constructed interview. Both types of data collected and analyzed enable us to draw conclusions about scent marketing in Umeå. In this paper we identify the stores in Umeå that have odours or perfumes, those that are using smell as a marketing tool and their reasons to use it or not.</p><p><--></p>
98

Scent Marketing: What is the impact on stores in Umeå?

Blondeau, Mathieu, Tran, Amélie January 2009 (has links)
The way of consumption has changed. Now, consumers are not only rational when purchasing. They do not buy just for the functionality of the good or service they are looking for. The consumption is more affective and consumers are considered now as poly-sensorial entities that are looking for more emotional and sensorial stimulation during their purchase process. This evolution of consumption is part of the trend that is called “retailtainnment”, a mixed of “Retail” and “Entertainment”. It is a concept of distribution that combines both of those two activities. Earlier studies have shown the success of using the Sensory Marketing, a concept based on stimulating the five senses in a strategy view. But, if certain senses are heavily used by companies/brands, as the sight and hearing, some are still underused, as the touch, the taste and particularly the smell. Wherefore a study on scent marketing is considered relevant to measure the potential of it. Even if several studies have already explained the important role of smell in a company’s strategy, only few of them are using it. Our paper aims to go further on this subject by understanding the scent marketing in stores through the aims, the obstacles, the techniques used, in Umeå, Sweden. For our research, we first had to collect knowledge from scientific articles and previous studies on odours, on smells or perfumes and on scent marketing. Then, we constructed three hypothesises that helped us to conduct our research and made conclusions. Those hypotheses will be discussed by conducting a mixed-method, that is to say by combining two types of researches: a quantitative one, mainly to measure how many stores are using smell as a marketing tool, and then a qualitative one to go deeper into the reasons and how those stores are applying it. The quantitative research, based on a deductive approach, was conducted by using questionnaires. The qualitative research, based on an inductive approach was conducted by making semi-constructed interview. Both types of data collected and analyzed enable us to draw conclusions about scent marketing in Umeå. In this paper we identify the stores in Umeå that have odours or perfumes, those that are using smell as a marketing tool and their reasons to use it or not.
99

Cellular and Synaptic Organization of the Human Olfactory Bulb

Maresh, Alison 04 March 2008 (has links)
The distribution of cell types and synapses is well characterized in the rodent olfactory bulb (OB), and from that plausible models of odor processing have been constructed. Individual olfactory sensory neurons (OSNs) express only 1 of ~1000 odorant receptors (ORs) and send their axons to specific synaptic targets in the OB glomerular neuropil. Each glomerulus is innervated exclusively by OSN axons expressing the same OR. The distribution of these glomeruli is conserved across animals, as is the numerical relationship between number of expressed ORs and number of glomeruli in the OB. Our objective is to extend such results to the level of the human OB to determine how its cellular and synaptic organization, and more specifically how the number and distribution of its glomeruli, compare to what has been elucidated in mice. As there are ~2,000 glomeruli for ~1,000 ORs in mice, we predicted ~700 glomeruli in humans based on the ~350 intact OR genes identified in the human through genomic studies. Using immunohistochemistry, the organization of cells and synapses in human OBs was evaluated and quantified. While the laminar structure of the OB is broadly conserved between species, in the human OB the laminar organization as well as additional structural features suggest a less rigorously organized OB than in rodents, perhaps suggesting that odor processing in the human OB may be less efficient than in mice. Of particular note, the total number of glomeruli in the human OB differs significantly from predicted and demonstrates a high degree of variability amongst specimens, thus far ranging from approximately 3000 - 9000/OB. These results indicate that the principles of OR-homotypic axon convergence developed from mouse studies may not be readily applicable to the human, and that central processing of odor signals in the human may differ from those characterized in the mouse.
100

Nematomo žymens registravimo prekių ženklu teisinė problematika / Legal problems of registering a trade mark consisting of a non-visible sign

Zmejauskaitė, Rūta 18 April 2013 (has links)
Disertacijoje analizuojama, kokiomis sąlygomis nematomi žymenys atlieka pagrindinę prekių ženklo funkciją, t.y. atskiria vieno asmens prekes ir paslaugas nuo kito asmens prekių ir paslaugų. Atsakant į šį klausimą aptariamos pagrindinės kvapo, skonio ir garso charakteristikos, išskiriamos pagrindinės kvapo, skonio ir garso žymenų rūšys, identifikuojami nematomų žymenų funkcionalumo aspektai, identifikuojami pagrindiniai konkurenciniai aspektai, analizuojami išeikvojimo doktrinos taikymo ypatumai nematomų prekių ženklų atžvilgiu. Taip pat disertacijoje analizuojama nematomo žymens galimybės būti pavaizduotam grafiškai problematika. Aptariama grafinio pavaizdavimo reikalavimo esmė, paskirtis ir vieta absoliučių reikalavimų prekių ženklui sistemoje, analizuojami atskirų tipų nematomų žymenų grafinio pavaizdavimo ypatumai, atskirai aptariant šiuo metu žinomus nematomų žymenų grafinio pavaizdavimo metodus: žodinį žymenų aprašymą, cheminę formulę, nematomų žymenų pavyzdžių (angl. specimen) tinkamumą, atvaizdą, kvapo diagramas, kvepalų radarą, muzikinę penklinę ir garso diagramas. / This dissertation investigates the conditions under which a non-visible sign performs the primary function of a trade mark, i.e. to distinguish the goods or services of one undertaking from those of other undertakings. To answer this question, the dissertation identifies the main characteristics of smell, taste, and sound, the main types of smell, taste and sound signs, the functionality of non-visible signs, the main competitive aspects, and the peculiarities applying the depletion doctrine with respect to non-visible signs. The dissertation deals with the capability of a non-visible sign to be represented graphically. It describes the essence, purpose and role of the graphical representation requirement in the array of absolute requirements for a trade mark, also analyses the peculiarities of representation of different types of non-visible signs, by focusing more on graphical representation methods known today, such as verbal description of signs, chemical formula, relevance of specimen of non-visible signs, image, diagrams of smell, perfume radar, musical staves, and diagrams of sound.

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