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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
171

Aplica??o da metodologia seis sigma em uma empresa de m?dio porte do setor t?xtil / Application of Six Sigma methology in a medium-sizes textile enterprize

Feitor, Carlos David Cequeira 21 July 2008 (has links)
Made available in DSpace on 2014-12-17T14:52:45Z (GMT). No. of bitstreams: 1 CarlosDCF.pdf: 2847363 bytes, checksum: b2246e198dec7f41fa36de8369078e4b (MD5) Previous issue date: 2008-07-21 / The Six Sigma methodology has received considerable attention in the last two decades. This is due to its great potencial to reduce processes variability, through the use of accurate data, facts and statistical techniques. The methodology seeks to improve the quality of products and services, maximizing the company s financial performance. Specifically, its implementation and results in medium-sized textile enterprises is unknow, although there are signs that the methodology can be applied with success. Considering this scenario, the goal of this research is to describe the application of the Six Sigma methodology in a m?dium-sized textile company specialized in the production of male shirts in the satate of Rio Grande do Norte, Brazil. First, we present a literature review, seeking to highlight the themes of quality, Six Sigma and its methodology for improvement. Then, we show the implementation of the project selected, depicting the steps and procedures that must be performed. The results confirm the efficiency of Six Sigma in providing significant gains to companies. It is observed substantial improvements in the speed of product development and the flexibility of the parts produced, reducing the process lead time from 12.5 to 6.2 days, which means a performance improvement of over 50%. This leads also to cultural and behaviour change, creating motivation for implementation of new projects and a continuous search for knowledge / O programa Seis Sigma tem recebido bastante aten??o nas ?ltimas duas d?cadas, em fun??o de sua grande capacidade em reduzir a variabilidade dos processos, por meio do uso rigoroso de dados, fatos e t?cnicas estat?sticas que buscam melhorar a qualidade dos produtos e servi?os, impulsionando e maximizando os resultados financeiros da empresa. Contudo, a sua aplica??o e resultados em empresas de m?dio porte do setor t?xtil ? desconhecido, todavia h? ind?cios de que possa ser implantado com o mesmo sucesso verificado em outros setores industriais. Diante disso, o objetivo desta disserta??o de mestrado ? apresentar e desenvolver um estudo aplicado para a introdu??o do Seis Sigma em uma empresa de confec??o de camisaria masculina no Rio Grande do Norte. Para tanto, inicialmente foi realizada uma revis?o bibliogr?fica, procurando destacar os temas da qualidade, Seis Sigma e a sua metodologia para melhoria. Em seguida, ? apresentada a aplica??o do projeto selecionado, demonstrando os passos e procedimentos que devem ser trilhados para condu??o do projeto. Na seq??ncia, os resultados s?o relacionados, confirmando a efici?ncia do Seis Sigma em trazer ganhos significativos para as empresas. Os resultados da pesquisam apontam melhorias substanciais na rapidez do desenvolvimento do produto e na flexibilidade das pe?as elaboradas, reduzindo o Lead Time do processo de 12,5 para 6,2 dias, ou seja, uma melhoria no desempenho superior a 50%. Destaca-se, tamb?m, a mudan?a cultural e de comportamento dos colaboradores ap?s a compreens?o do programa e a implanta??o do mesmo, gerando motiva??o para aplica??o de novos projetos e pela procura cont?nua do conhecimento no intuito de avan?ar em pr?ticas e ferramentas mais avan?adas
172

Diagn?stico Socioambiental da disposi??o final dos res?duos s?lidos no distrito de Guajiru S?o Gon?alo do Amarante/RN, ressaltando a situa??o socioecon?mica dos catadores

Santos, Kelly Cristina Dantas dos 09 April 2010 (has links)
Made available in DSpace on 2014-12-17T14:52:53Z (GMT). No. of bitstreams: 1 KellyCDS_DISSERT.pdf: 5631714 bytes, checksum: a290ca2f92ef1eb6c155792a1a6b25bf (MD5) Previous issue date: 2010-04-09 / One of the concerns of this century is with the handling and the final destination of urban solid waste (RSU), where depending on the form as they will be made use, they can cause diverse problems, they are of ambient or social order, being able to generate the loss of the quality of life and illnesses to the population, of direct or indirect form. The objective of the present work was to diagnosis the environmental partner situation of the Final Destination of the urban solid residues in the District of Guajiru, city of S?o Gon?alo do Amarante/RN, standing out the partner-economic situation of the scavengers. The research was carried through in the period of March of 2008 the October of 2009, with a methodology developed through analyzes them of documents made available for the state ambient agency, the Air base of Christmas and managing agencies of the city. For collection of the date, it was used directly application of the questionnaire with 20 existing scavengers in points of destination of residues, evaluation of the old place of final destination through the use of the spread sheet of the IQR (Index of Quality of the Residues), developed for the CETESB, identification of the matter dump and photographic register. For effect of treatment of the data, a descriptive analysis with regard to the answers of the interviewed scavengers was carried through. The acquired date, Scale had been according to tabulated and analyzed in Excel 2003, where they had been generated graphical to observe the behavior of the data. The results show that of the twenty interviewed scavengers, 35% possess age between 20 and 30 years; 75% possess incomplete basic education; 60% inhabit in houses of waal or huts (cardboard or wood); 55% do not make use of system of water supply and system of sanitary exhaustion; with regard to income monthly for scavengers, 35% had presented income between R$ 200,00 and R$300,00 and 20% possess income above of R$ 500,00 for possessing another source of income; 80% of the interviewed ones, use some type of equipment of individual protection; In the year of 2009, confirming what it was informed by the State agency of Environment, during the field visit, we evidence that the city of Is Gon?alo do Amarante, currently, destines its residues in Sanitary landfill of S?o Region Metropolitan of Natal in the District of Massaranduba in the city of Cear?-Mirim, after some interventions of the State Public prosecution service. However, in the district of Guajiru some diggings still exist that today are used as final destination of RCD' s (Residues of Construction and Demolition) of the cities of Natal and S?o Gon?alo do Amarante, as well as private dumps that are used by scavengers that deviate the final destination (Sanitary landfill) of the residues of the great generators (supermarkets, shopping Center and hotels), with presence of urubus, generating a new ambient problem for the city and the aeroportu?ria security. Ahead of this scene, the study it suggests viable alternatives for the elimination of the private dumps and for the social situation of the escavengers, aiming at to improve its quality of life and 10 to minimize the ambient impacts caused by the inadequate destination of the solid waste in the community of Guajiru, S?o Gon?alo do Amarante/RN, being able to contribute so that the public managers carry through action in the handling and the control of the final destination of the urban solid waste / Uma das preocupa??es deste s?culo ? com o manejo e a destina??o final dos Res?duos S?lidos Urbanos (RSU), onde dependendo da forma como forem dispostos, podem ocasionar diversos problemas, sejam de ordem ambiental ou social, podendo gerar a perda da qualidade de vida e doen?as ? popula??o, de forma direta ou indireta. O objetivo do presente trabalho foi diagnosticar a situa??o socioambiental do Destino Final dos res?duos s?lidos urbanos no Distrito de Guajiru, munic?pio de S?o Gon?alo do Amarante/RN, ressaltando a situa??o s?cio-econ?mica dos catadores. A pesquisa foi realizada no per?odo de mar?o de 2008 a outubro de 2009, com uma metodologia desenvolvida atrav?s das an?lises de documentos disponibilizados pelo ?rg?o ambiental estadual, pela Base A?rea de Natal e por ?rg?os gestores do munic?pio. Para coleta dos dados, utilizou-se a aplica??o do question?rio diretamente com 20 catadores existentes em pontos de destina??o de res?duos, avalia??o do antigo local de destina??o final atrav?s da utiliza??o da planilha do IQR (?ndice de Qualidade dos Res?duos), desenvolvido pela CETESB, identifica??o dos lix?es particulares e registro fotogr?fico. Para efeito de tratamento dos dados, foi realizada uma an?lise descritiva com rela??o as respostas do catadores entrevistados. Os dados adquiridos, segundo a Escala foram tabulados e analisados no Excel 2003, onde foram gerados gr?ficos para observar o comportamento dos dados. Os resultados mostraram que dos vinte catadores entrevistados, 35% possuem idade entre 20 e 30 anos; 75% possuem Ensino Fundamental incompleto; 60% residem em casas de taipa ou barracos (papel?o ou madeira); 55% n?o disp?em de sistema de abastecimento d ?gua e sistema de esgotamento sanit?rio; com rela??o ? renda mensal por catadores, 35% apresentaram renda entre R$ 200,00 e R$300,00 e 20% possuem renda acima de R$ 500,00 por possu?rem outra fonte de renda; 80% dos entrevistados utilizam algum tipo de equipamento de prote??o individual. No ano de 2009, confirmando o que foi informado pelo ?rg?o Estadual de Meio Ambiente, durante a visita de campo, constatamos que o munic?pio de S?o Gon?alo do Amarante, atualmente, destina seus res?duos no Aterro Sanit?rio da Regi?o Metropolitana do Natal no Distrito de Massaranduba no munic?pio de Cear?-Mirim, ap?s v?rias interven??es do Minist?rio P?blico Estadual. Contudo, no distrito de Guajiru existem ainda algumas cavas que hoje s?o utilizadas como destino final de RCD s (Res?duos de Constru??o e Demoli??o) dos munic?pios de Natal e S?o Gon?alo do Amarante, assim como lix?es particulares que s?o utilizados por catadores que desviam o destino final (Aterro Sanit?rio) dos res?duos dos grandes geradores (supermercados, shopping Center e 8 hot?is), com presen?a de urubus, gerando um novo problema ambiental para o munic?pio e para a seguran?a aeroportu?ria. Diante deste cen?rio, o estudo sugere alternativas vi?veis para a elimina??o dos lix?es particulares e para a situa??o social dos catadores, visando melhorar a sua qualidade de vida e minimizar os impactos ambientais causados pela destina??o inadequada dos res?duos s?lidos na comunidade de Guajiru, S?o Gon?alo do Amarante/RN, podendo contribuir para que os gestores p?blicos realizem a??es no manejo e no controle do destino final dos res?duos s?lidos urbanos
173

Estudos dos aspectos qualitativos e quantitativos da ?gua e do sedimento no baixo curso do Rio Pitimbu (RN)

Kobayashi, Rafael Takeshi 11 September 2009 (has links)
Made available in DSpace on 2014-12-17T15:03:23Z (GMT). No. of bitstreams: 1 RafaelTK.pdf: 4947639 bytes, checksum: b0c9b4c48d718068bc5e78a7565840ba (MD5) Previous issue date: 2009-09-11 / Urban growth of metropolitan areas has produced impacts of considerable importance on environment and water resources. Such impacts are in general associated with human activities, such as basin area uncontrolled development. In this context, Pitimbu river watershed, located at Natal metropolitan area, has been affected by uncontrolled development caused by urban expansion. Indeed, such effects have been reflected on water quantity and quality, which may produce social consequences. Pitimbu river is an important water supplier for human consumption, actually supplying a 2600 m3/h water discharge. This study aims to analyze the qualitative and quantitative aspects of water and sediment on Pitimbu river lowland portion. For this purpose, physical-chemical water properties were analyzed, and sediment macro invertebrates benthonic were monitored in two cross sections in a period between November 8th, 2007 and October 3rd, 2008. Monitoring methodology consisted of water and sediment sampling for laboratory analysis. Water quality analysis included Dissolved Oxygen, Oxygen Biochemical Demand, Nitrate, pH and Alkalinity, Suspended and Total Solids. The analysis of heavy metals in the sediment included Cadmium, Cobalt, Copper, Chrome, Silver and Nickel. Dry season water discharge data were measured and used to adjust recession function parameters, whose values reveal quick recession and strong river-aquifer unconfined interaction. Water quality analysis revealed the absence of degradation by organic composites. However, DO and BOD levels indicate that more consistent results could be provided if sampling time interval were reduced. Biomonitoring showed signs of aquatic ecosystem degradation by the absence of sensitive and abundance of resistant benthic organisms. Obtained results demonstrate the urgent need of effective management measures to provide environmental protection. The increase of environmental degradation will certainly make impracticable the use of water for human consumption / A expans?o urbana das regi?es metropolitanas tem produzido impactos negativos de grande import?ncia no meio ambiente e nos recursos h?dricos. Esses impactos est?o relacionados com as atividades antr?picas na bacia hidrogr?fica, refletidas no descontrole do uso e ocupa??o do solo. Nesse contexto, a Bacia Hidrogr?fica do rio Pitimbu, situada na regi?o metropolitana de Natal, tem sido objeto de ocupa??o desordenada, motivada pela expans?o urbana. Os efeitos dessa ocupa??o tem se refletido na qualidade e quantidade da ?gua desse rio, com conseq??ncias sociais importantes. O rio Pitimbu ? manancial de abastecimento, suprindo atualmente uma vaz?o de 2600 m3/h. Este estudo tem como objetivo analisar aspectos quali-quantitativos da ?gua e do sedimento no baixo curso do rio Pitimbu. Para isso, foram realizadas an?lises f?sico-qu?micas da ?gua e biomonitoramento envolvendo macro-invertebrados bent?nicos em duas se??es transversais no per?odo de 8/11/2007 a 3/10/2008. O monitoramento consistiu na coleta de amostras da ?gua e do sedimento fluvial e posterior analise em laborat?rio. Foram analisados Oxig?nio Dissolvido, Demanda Bioqu?mica de Oxig?nio, Nitrato, pH, Alcalinidade, S?lidos Suspensos e Totais, al?m dos teores de C?dmio, Cobalto, Cobre, Cromo, Prata e N?quel. O monitoramento da descarga l?quida no per?odo seco permitiu o ajuste dos par?metros da fun??o de recess?o, demonstrando recess?o r?pida com forte intera??o rio-aqu?fero n?o confinado. A an?lise da qualidade da ?gua revelou aus?ncia de degrada??o por subst?ncias org?nicas. Apesar disso, os n?veis de OD e DBO indicam que resultados mais conclusivos poderiam ser obtidos se o intervalo entre coletas fosse reduzido. O biomonitoramento revelou sinais de degrada??o do ecossistema aqu?tico pela aus?ncia de bent?nicos sens?veis e abund?ncia de resistentes. Os resultados obtidos demonstram a necessidade de que sejam adotadas medidas eficientes de gerenciamento que resultem na prote??o ambiental na bacia. O aumento do n?vel de degrada??o inviabilizar? o uso da ?gua para consumo humano no futuro
174

Express?o Imuno-histoqu?mica das prote?nas GLUT-1 e HIF-1? em les?es vasculares de mucosa oral

Oliveira, Denise H?len Imaculada Pereira de 16 February 2012 (has links)
Made available in DSpace on 2014-12-17T15:32:20Z (GMT). No. of bitstreams: 1 DeniseHIPO_DISSERT.pdf: 4556175 bytes, checksum: 89c325ea02bf77fa8472508c05c7634d (MD5) Previous issue date: 2012-02-16 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior / The correct histological diagnosis of vascular lesions in the oral mucosa is critical, especially in defining the treatment and prognosis, as some vascular lesions show spontaneous involution and others do not show such behavior. This study analyzed the expression immunohistochemistry of human glucose transporter protein (GLUT-1), in oral benign vascular tumors and to reclassify such lesions according to with his immunoexpression. In addition, we evaluated the immunohistochemical expression of hypoxia-inducible factor 1 alpha (HIF-1?), the main transcription factor involved in cellular adaptation to hypoxia. We analyzed 60 cases of benign oral vascular tumors: 30 cases with histological diagnosis of HEM and 30 cases of oral pyogenic granuloma (PG). The results of this research showed that of the 30 lesions initially classified as HEM, only 7 showed immuno-positivity for GLUT-1, remaining with the initial diagnosis. The remaining 23 were reclassified as vascular malformation (VM) (13 cases) and PG (10 cases). All cases in the sample with an initial diagnosis of PG were negative for GLUT-1, demonstrating the accuracy of histological diagnosis of these lesions. Concerning to the immunoexpression of HIF-1?, the Mann-Whitney test revealed a statistically significant difference between the cases of GP and MV (p = 0.002), where the median of GP (m=78) was higher than the MV (m=53). Based on these results, this study showed that a histological diagnosis alone is not always sufficient for the correct diagnosis of oral HEM and that HIF-1? participates in the pathogenesis of vascular lesions / O correto diagn?stico histol?gico de les?es vasculares em mucosa oral ? fundamental, sobretudo na hora de definir o tratamento e progn?stico, visto que algumas dessas les?es apresentam involu??o. Este trabalho analisou a express?o imunohistoqu?mica da prote?na humana transportadora de glicose (GLUT-1), em tumores vasculares benignos orais e reclassificou tais les?es de acordo com sua imunoexpress?o. Al?m disso, avaliou a express?o imuno-histoqu?mica do fator 1 induz?vel por hip?xia (HIF-1?), principal fator de transcri??o envolvido na adapta??o celular ? hip?xia. Foram analisados 60 casos de tumores vasculares benignos orais, sendo 30 casos com diagn?stico histol?gico de HEM e 30 casos de granulomas piog?nicos orais (GP). Os resultados desta pesquisa demonstraram que das 30 les?es inicialmente classificadas como HEM, apenas 7 apresentaram imuno-positividade para GLUT-1, permanecendo com o diagn?stico inicial. As 23 restantes foram reclassificadas em malforma??o vascular (MV) 13 casos e GP 10 casos . Todos os casos da amostra com diagn?stico inicial de GP apresentaram-se negativos para GLUT-1. Quanto ? imunoexpress?o do HIF-1?, o teste de Mann-Whitney revelou diferen?a estatisticamente significativa entre os casos de GP e MV(p=0,002), onde a mediana do GP (m=78) foi superior a da MV (m=53). Com base nesses resultados, este estudo mostrou que o diagn?stico histol?gico por si s? nem sempre ? suficiente para o diagn?stico correto do HEM oral e que o HIF- 1? participa da patog?nese das les?es vasculares
175

Monitoramento da sobreviv?ncia de portadores de c?ncer de boca e orofaringe no RN via gr?fico Rast Cusum

Euflausino, Waleska Cristina 16 December 2016 (has links)
Submitted by Automa??o e Estat?stica (sst@bczm.ufrn.br) on 2018-03-12T14:16:55Z No. of bitstreams: 1 WaleskaCristinaEuflausino_DISSERT.pdf: 2155309 bytes, checksum: 4d1605e644787439d12a4dd235990b92 (MD5) / Approved for entry into archive by Arlan Eloi Leite Silva (eloihistoriador@yahoo.com.br) on 2018-03-14T19:58:05Z (GMT) No. of bitstreams: 1 WaleskaCristinaEuflausino_DISSERT.pdf: 2155309 bytes, checksum: 4d1605e644787439d12a4dd235990b92 (MD5) / Made available in DSpace on 2018-03-14T19:58:05Z (GMT). No. of bitstreams: 1 WaleskaCristinaEuflausino_DISSERT.pdf: 2155309 bytes, checksum: 4d1605e644787439d12a4dd235990b92 (MD5) Previous issue date: 2016-12-16 / T?cnicas de controle estat?stico de processos (CEP), comumente usadas em problemas industriais, podem tamb?m ser aplicadas na ?rea da sa?de, tendo em vista que a qualidade em procedimentos m?dicos faz parte integrante do dia a dia nas estruturas hospitalares. Contudo, neste caso, a popula??o em estudo n?o pode ser considerada homog?nea como mercadorias em uma linha de produ??o. A aplica??o do CEP na ?rea de sa?de precisa admitir a exist?ncia de heterogeneidade, levando em considera??o caracter?sticas particulares de cada paciente como, por exemplo, sexo, idade, al?m de medidas que reflitam as condi??es gerais de sa?de. Neste sentido, alguns autores prop?em o monitoramento do tempo de sobreviv?ncia de pacientes, atrav?s de um gr?fico de controle de Somas Acumuladas - CUSUM (Cumulative Sum), ajustado para incorporar o risco de cada indiv?duo por meio de um modelo param?trico de regress?o. Este gr?fico ? chamado pelos autores de Gr?fico de Controle CUSUM Ajustado ao Risco (RAST CUSUM), e os resultados te?ricos foram desenvolvidos para monitorar tempos at? a ocorr?ncia de um evento, mesmo quando estes est?o sujeito a informa??es incompletas (censura ? direita), atrav?s do modelo Weibull, muito comum na modelagem de dados de sobreviv?ncia. Neste trabalho o gr?fico RAST CUSUM Weibull foi empregado com o objetivo geral de monitorar, em um estudo retrospectivo, os tempos de sobreviv?ncia dos pacientes diagnosticados com c?ncer de boca e orofaringe da Liga Norte Riograndense Contra o C?ncer no per?odo de 2001 a 2013. Os dados deste trabalho s?o oriundos da base de dados da Liga sendo registradas al?m das datas do diagn?stico e da ?ltima consulta na institui??o, caracter?sticas s?cio demogr?ficas e cl?nicas dos pacientes, consideradas como potenciais fatores de risco para redu??o no tempo m?dio de sobreviv?ncia desses indiv?duos. Como resultado do monitoramento, que levou em considera??o os fatores localiza??o e tamanho do tumor, tipo do primeiro tratamento adotado e hist?rico familiar, foi detectado um aumento de 20 % no tempo m?dio de sobreviv?ncia dos pacientes a partir do ano 2005. / Statistical process control techniques are commonly used in industrials problems and can also be applied in the health area, since quality in medical procedures are an integral part of day-to-day hospital structures. However, in this case, the population can not be regarded as homogeneous as goods in a production line. The application of the CEP in the health area must admit the existence of heterogeneity, taking into account particular characteristics of each patient with, for example, gender, age, and measures that reflect the general health conditions. In this sense, some authors propose monitoring survival time of patients, through a CUSUM (Cumulative Sum) chart, adjusted to incorporate the risk of each individual by a parametric regression model. This chart is called by the authors of RAST CUSUM, and the theoretical results were developed to monitor times until the occurrence of an event, even when they are subject to incomplete information (right censoring), considering for that the Weibull model, which is very used to model survival data. In this work the RAST CUSUM Weibull graph was used in a retrospective study, to monitoring the survival of patients with oral and oropharyngeal cancer, treated on the Northern Riograndense League of the c?ncer, from 2001 to 2013. The data of this work come from the data base of the hospital being registered beyond the dates of diagnosis and last visit to the institution, socio-demographic characteristics and clinics of patients, considered as potential risk factors for mean survival time of these individuals. As a result of the monitoring that considered the location and size of the tumor, type of the first treatment adopted and family history as risk factors, an increase of 20% in the mean survival time of the patients from 2005 was detected.
176

Estaniocalcina 2 modula eventos importantes para a tumorig?nese oral e ? um marcador progn?stico para pacientes com carcinoma de c?lulas escamosas oral

Carmo, Andr?ia Ferreira do 15 December 2017 (has links)
Submitted by Automa??o e Estat?stica (sst@bczm.ufrn.br) on 2018-03-21T11:50:05Z No. of bitstreams: 1 AndreiaFerreiraDoCarmo_TESE.pdf: 2170675 bytes, checksum: 49a8001d1651a77b1ebea9cb5d0cc766 (MD5) / Approved for entry into archive by Arlan Eloi Leite Silva (eloihistoriador@yahoo.com.br) on 2018-03-23T11:55:44Z (GMT) No. of bitstreams: 1 AndreiaFerreiraDoCarmo_TESE.pdf: 2170675 bytes, checksum: 49a8001d1651a77b1ebea9cb5d0cc766 (MD5) / Made available in DSpace on 2018-03-23T11:55:44Z (GMT). No. of bitstreams: 1 AndreiaFerreiraDoCarmo_TESE.pdf: 2170675 bytes, checksum: 49a8001d1651a77b1ebea9cb5d0cc766 (MD5) Previous issue date: 2017-12-15 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior (CAPES) / O horm?nio glicoproteico estaniocalcina 2 (STC2) est? envolvido na carcinog?nese e progress?o de muitos tipos de c?ncer. No entanto, seu significado cl?nico e mecanismos moleculares no carcinoma de c?lulas escamosas oral (CCEO) foram pouco estudados e permanecem incertos. O presente estudo investigou associa??es da express?o da STC2 com par?metros clinicopatol?gicos e de sobrevida em pacientes com CCEO. Al?m disso, foram avaliados os efeitos biol?gicos causados pela redu??o dos n?veis de STC2 em linhagens celulares de CCEO e fibroblastos associados ao c?ncer (do ingl?s CAF ? carcinoma associated fibroblasts). A an?lise imunoistoqu?mica em 100 casos de CCEOs prim?rios indicou que a superexpress?o da STC2 foi associada com o par?metro N do sistema TNM e foi um fator de risco independente para sobrevida espec?fica da doen?a e sobrevida livre de doen?a em pacientes com CCEO. Usando ensaios in vitro, foi demonstrado que o silenciamento da STC2 em linhagens de CCEO promoveu a apoptose e reduziu a prolifera??o celular, migra??o, invas?o e transi??o epit?lio-mesenquimal. An?lises adicionais revelaram que o CAF expressa maiores n?veis de STC2 do que as c?lulas de CCEO. O silenciamento da STC2 no CAF reduziu a invas?o celular do CCEO, sugerindo que a STC2 liberada por CAFs contribui para um fen?tipo mais invasivo no CCEO. Esses resultados sugerem que a STC2 modula eventos importantes para a tumorig?nese oral e pode ser um biomarcador progn?stico para pacientes com CCEO. / The glycoprotein hormone stanniocalcin 2 (STC2) is involved in carcinogenesis and progression of several cancer types. However, its clinical significance and molecular mechanisms in oral squamous cell carcinoma (OSCC) have been partially studied and remain uncertain. In the present study, we investigated associations of STC2 expression with clinicopathological and survival parameters of OSCCs patients. We also determined the biological effects caused by STC2 downregulation in OSCC and cancer associated fibroblasts (CAF) cell lines. Immunohistochemical analysis in 100 cases of primary OSCC indicated that STC2 overexpression was associated with N stage (TNM staging) and was an independent risk factor for disease-specific survival and disease-free survival in patients with OSCC. Using in vitro assays, we demonstrated that STC2 knockdown in OSCC cell lines promoted apoptosis, and reduced cell proliferation, migration, invasion and epithelial-mesenchymal transition. Further analysis revealed that CAF expresses higher levels of STC2 than OSCC cells. Knockdown of STC2 in CAF reduced OSCC cell invasion, suggesting that STC2 released by CAF contributes to a more invasive phenotype in OSCC. These results suggest that STC2 modulates important events for oral tumorigenesis and can be a prognostic biomarker for OSCC.
177

Banco de termos da linguagem especial de enfermagem para pacientes com les?o por press?o / Bank of terms of the special nursing language for patients with pressure injury

Duarte, Fernando Hiago da Silva 18 December 2017 (has links)
Submitted by Automa??o e Estat?stica (sst@bczm.ufrn.br) on 2018-04-02T14:01:59Z No. of bitstreams: 1 FernandoHiagoDaSilvaDuarte_DISSERT.pdf: 1579770 bytes, checksum: 4bdbf99e4d88319fa3b83e83ac96e609 (MD5) / Approved for entry into archive by Arlan Eloi Leite Silva (eloihistoriador@yahoo.com.br) on 2018-04-05T11:53:40Z (GMT) No. of bitstreams: 1 FernandoHiagoDaSilvaDuarte_DISSERT.pdf: 1579770 bytes, checksum: 4bdbf99e4d88319fa3b83e83ac96e609 (MD5) / Made available in DSpace on 2018-04-05T11:53:40Z (GMT). No. of bitstreams: 1 FernandoHiagoDaSilvaDuarte_DISSERT.pdf: 1579770 bytes, checksum: 4bdbf99e4d88319fa3b83e83ac96e609 (MD5) Previous issue date: 2017-12-18 / A les?o por press?o ? o resultado da press?o prolongada sobre uma ?rea do corpo do paciente diminuindo a circula??o sangu?nea minimizando a distribui??o de sangue, nutrientes e oxig?nio nesta ?rea desencadeando destrui??o e morte tecidual, pois o tecido mole ? comprimido entre uma proemin?ncia ?ssea e uma superf?cie r?gida durante um per?odo de tempo prolongado. O banco de termos da linguagem especial de enfermagem identifica conceitos que contribuem com a constru??o de diagn?sticos, resultados e interven??es de enfermagem. A utiliza??o desse banco direcionada a pacientes com les?o por press?o permite desenvolver de forma piramidal a identifica??o de um vocabul?rio pr?prio direcionado ao cuidado de enfermagem. O estudo teve por objetivo construir um banco de termos da linguagem especial da enfermagem para pacientes com les?o por press?o utilizando a CIPE? vers?o 2017, com base na Teoria das Necessidades Humanas B?sicas. Trata-se de um estudo terminol?gico em um hospital privado na capital do nordeste do Brasil desenvolvida em seis etapas: 1) Identifica??o e coleta dos termos relevantes ? pr?tica da Enfermagem relacionada ? les?o por press?o; 2) Extra??o dos termos dos prontu?rios e elimina??o das repeti??es; 3) Normaliza??o dos termos; 4) Mapeamento cruzado entre termos extra?dos e os termos constantes na CIPE? vers?o 2017; 5) Refinamento dos termos; 6) Valida??o das afirmativas do banco de termos. Obteve-se aprova??o do Comit? de ?tica em Pesquisa da Universidade Federal do Rio Grande do Norte, sob parecer n? 2.356.736 e Certificado de Apresenta??o para Aprecia??o ?tica n? 76777017.20000.5537. Identificaram-se 391 termos que foram submetidos ao processo de mapeamento cruzado e valida??o de especialistas que resultou em 370 termos, sendo 225 termos constantes e 145 termos n?o constantes na Classifica??o Internacional para a Pr?tica de Enfermagem, vers?o 2017. O estudo permitiu explorar e conhecer os termos utilizados pelos enfermeiros na assist?ncia prestada ao paciente com les?o por press?o, possibilitando o desenvolvimento futuro dos enunciados de diagn?sticos / resultados e interven??es de enfermagem e tamb?m a unifica??o da linguagem profissional do enfermeiro. / Pressure injury is the result of prolonged pressure on an area of the patient's body by decreasing blood circulation, minimizing the distribution of blood, nutrients, and oxygen in this area, triggering destruction and tissue death, as the soft tissue is compressed between a bone prominence and a hard surface for an extended period of time. The terms bank of the special nursing language identifies concepts that contribute to the construction of nursing diagnoses, results and interventions. The use of this bank aimed at patients with pressure lesions allows the development of a pyramidal identification of an own vocabulary directed to nursing care. The aim of the study was to construct a bank of terms of the special nursing language for patients with pressure injury, using the International Classification for Nursing Practice version 2017. This is a terminological study in a private hospital in the northeast capital of the Brazil developed in six steps: 1) Identification and collection of terms relevant to the practice of Nursing related to pressure injury; 2) Extraction of the terms of the medical records and elimination of repetitions; 3) Standardization of terms; 4) Cross-mapping between extracted terms and the terms in CIPE? version 2017; 5) Refinement of terms; 6) Validation of the terms bank statements. Approval was obtained from the Research Ethics Committee of the Federal University of Rio Grande do Norte, under opinion no. 2.356.736 and Certificate of Presentation for Ethical Appreciation n? 76777017.20000.5537. It was identified 391 terms that were submitted to the process of cross-mapping and validation of specialists that resulted in 370 terms, being 225 constant terms and 145 terms not included in the International Classification for Nursing Practice, version 2017. The study allowed to explore and to know the terms used by nurses in the care provided to the patient with pressure injury, allowing the development of statements of diagnosis/results and nursing interventions and also the unification of nurses' professional language.
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Valida??o do diagn?stico de enfermagem: risco de ?lcera por press?o / Validation of the nursing diagnosis of pressure ulcer risk

Medeiros, Ana Beatriz de Almeida 08 August 2016 (has links)
Submitted by Automa??o e Estat?stica (sst@bczm.ufrn.br) on 2017-01-27T13:30:49Z No. of bitstreams: 1 AnaBeatrizDeAlmeidaMedeiros_TESE.pdf: 2411384 bytes, checksum: 92c650f6680920b2f593c10ef84b8ed7 (MD5) / Approved for entry into archive by Arlan Eloi Leite Silva (eloihistoriador@yahoo.com.br) on 2017-01-31T13:24:12Z (GMT) No. of bitstreams: 1 AnaBeatrizDeAlmeidaMedeiros_TESE.pdf: 2411384 bytes, checksum: 92c650f6680920b2f593c10ef84b8ed7 (MD5) / Made available in DSpace on 2017-01-31T13:24:12Z (GMT). No. of bitstreams: 1 AnaBeatrizDeAlmeidaMedeiros_TESE.pdf: 2411384 bytes, checksum: 92c650f6680920b2f593c10ef84b8ed7 (MD5) Previous issue date: 2016-08-08 / Este estudo objetivou validar o diagn?stico de enfermagem Risco de ?lcera por press?o em pacientes internados na unidade de terapia intensiva. Diante da gravidade, complexidade e grau de depend?ncia dos pacientes cr?ticos, surge a necessidade da enfermagem avaliar a presen?a desse diagn?stico para atuar na preven??o dos fatores de risco e na manuten??o da qualidade nos servi?os ofertados. Tratou-se de um estudo metodol?gico, desenvolvido em tr?s etapas: an?lise de conceito, an?lise do conte?do por especialistas e valida??o cl?nica. A primeira etapa foi baseada no modelo de Walker e Avant e operacionalizada atrav?s de revis?o da literatura, que aconteceu nos meses de fevereiro e mar?o de 2015. Utilizaram-se as bases de dados: Scopus, Literatura Latino-Americana e do Caribe em Ci?ncias da Sa?de, Cumulative Index to Nursing and Allied Health Literature, National Library of Medicine and Nattional Institutes of Health e Web of Science, e os descritores: ?lcera por press?o, fatores de risco e unidades de terapia intensiva e suas respectivas sinon?mias em ingl?s. Obteve-se uma amostra de 22 artigos. Ap?s a an?lise do conceito, identificaram-se 42 antecedentes e os seguintes atributos essenciais: Press?o; Press?o em combina??o com cisalhamento; e Isquemia tecidual. Na segunda etapa, foram solicitadas as opini?es dos especialistas com rela??o ? an?lise de conceito e de conte?do, por meio de grupo focal, composto por sete enfermeiras, em quatro encontros, durante os meses de maio a julho de 2015. Ap?s a discuss?o no grupo focal, resultou-se um total de 29 antecedentes e na seguinte defini??o conceitual para o diagn?stico estudado: Vulnerabilidade de rompimento da integridade da pele como resultado da isquemia tecidual ocasionada por press?o ou press?o em combina??o com cisalhamento. Na terceira etapa, foi realizado um estudo de caso-controle, com intuito de avaliar, na pr?tica cl?nica, a precis?o dos fatores de risco do diagn?stico de enfermagem identificados e validados nas etapas anteriores. Esta etapa ocorreu na unidade de terapia intensiva do Hospital Universit?rio Onofre Lopes, atrav?s de um formul?rio. A amostra consistiu de 180 participantes, sendo 90 no grupo caso e 90 no grupo controle. O projeto de pesquisa foi submetido e aprovado pelo Comit? de ?tica em Pesquisa do referido hospital, sob n?mero de protocolo 848.997 e Certificado de Apresenta??o para Aprecia??o ?tica 36883714.5.0000.5292. Os resultados mostram que, atrav?s da aplica??o do modelo de regress?o log?stica hier?rquica, um conjunto de cinco fatores de risco e um aspecto cl?nico deve ser visto como um forte indicativo do aumento do risco para ?lcera por press?o. Os fatores de risco foram: Hist?ria de ?lcera por press?o, Tempo prolongado de perman?ncia na UTI; Fric??o, Desidrata??o e Temperatura elevada da pele em torno de 1 a 2 ?C. E o aspecto cl?nico foi: Tratamento das comorbidades. Conclui-se que o diagn?stico de enfermagem Risco de ?lcera por press?o p?de ser validado em seus aspectos de conceito, de conte?do e cl?nicos e que existe um conjunto de vari?veis que aumentam a chance da ocorr?ncia do diagn?stico de enfermagem Risco de ?lcera por press?o em pacientes internados em unidade de terapia intensiva. Assim, acredita-se que o estudo contribuiu para o aperfei?oamento da linguagem diagn?stica, com vistas a ado??o de medidas preventivas, aplica??o de interven??es mais eficazes, alcance de resultados positivos e melhoria da qualidade do cuidado prestado pelo enfermeiro. / The objective of this study was to validate the nursing diagnosis ?Pressure ulcer risk? in patients admitted to the intensive care unit. Faced with the severity, complexity and degree of dependence of the critical patients, nursing needs to assess the presence of this diagnosis to act in the prevention of risk factors and maintenance of quality in the services offered. This was a methodological study, conducted in three steps: concept analysis, content analysis by experts and clinical validation. The first step was based on the model of Walker and Avant and performed through literature review, which occurred in the months of February and March 2015. We used the databases: Scopus, Latin American and Caribbean Health Sciences Literature, Cumulative Index to Nursing and Allied Health Literature, National Library of Medicine and National Institutes of Health, and Web of Science, and the descriptors: pressure ulcer, risk factors and intensive care units, and their respective synonyms in the English language. We obtained a sample of 22 papers. After completing the concept and content analysis, we identified 42 backgrounds and the following essential attributes: Pressure; Pressure combined with shearing; and Tissue ischemia. In the second step, we asked the experts to give opinions about the concept analysis, by means of a focus group, composed of seven nurses, in four meetings, which were held from May to July 2015. After finishing the discussion in the focus group, we had a total of 29 backgrounds, besides the following conceptual definition for the diagnosis under study: Vulnerability of rupture of the skin integrity as a result of the tissue ischemia provoked by pressure or pressure combined with shearing. In the third step, we conducted a case-control study with the aim of assessing, in clinical practice, the accuracy of the risk factors of the nursing diagnosis identified and validated in the preceding steps. This step took place in the intensive care unit of the Onofre Lopes University Hospital, through a form. The sample was composed of 180 participants, with 90 in the case group and 90 in the control group. The research project was submitted and approved by the Research Ethics Committee of the aforementioned hospital, under Protocol number 848.997 and Presentation Certificate for Ethics Assessment number 36883714.5.0000.5292. The results show that, through the application of the hierarchical logistic regression model, a set of five risk factors and one clinical aspect must be regarded as a strong indicator of the increased risk for pressure ulcer. The risk factors were: History of pressure ulcer; Extended period of stay in the ICU; Friction, Dehydration and High skin temperature around 1 to 2 ? C. As for the clinical aspect, it was: Treatment of comorbidities. We conclude that the nursing diagnosis of pressure ulcer risk could be validated in aspects of concept, content and clinical and that there is a set of variables that increase the chance of occurrence of the nursing diagnosis ?Pressure ulcer risk? in patients admitted to the intensive care unit. Accordingly, we believe that this study has contributed to the improvement of the diagnostic parlance, with regard to adopting preventive measures, applying more effective interventions, achieving positive results and improving the quality of the health care provided by the nursing professional.
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Diagn?stico de enfermagem risco de olho seco e ressecamento ocular em pacientes adultos internados em unidade de terapia intensiva / Nursing diagnosis risk of dry eye and ocular dryness in hospitalized adult patients in Intensive care unit

Ara?jo, J?ssica Naiara de Medeiros 04 October 2016 (has links)
Submitted by Automa??o e Estat?stica (sst@bczm.ufrn.br) on 2017-02-20T23:42:57Z No. of bitstreams: 1 JessicaNaiaraDeMedeirosAraujo_DISSERT.pdf: 1314685 bytes, checksum: 5277073c7a6b748dee41a1e611c029c5 (MD5) / Approved for entry into archive by Arlan Eloi Leite Silva (eloihistoriador@yahoo.com.br) on 2017-03-02T21:24:47Z (GMT) No. of bitstreams: 1 JessicaNaiaraDeMedeirosAraujo_DISSERT.pdf: 1314685 bytes, checksum: 5277073c7a6b748dee41a1e611c029c5 (MD5) / Made available in DSpace on 2017-03-02T21:24:47Z (GMT). No. of bitstreams: 1 JessicaNaiaraDeMedeirosAraujo_DISSERT.pdf: 1314685 bytes, checksum: 5277073c7a6b748dee41a1e611c029c5 (MD5) Previous issue date: 2016-10-04 / Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico (CNPq) / Objetivou-se avaliar o Diagn?stico de Enfermagem (DE) Risco de olho seco da NANDA-Internacional em pacientes internados em Unidade de Terapia Intensiva (UTI). Trata-se de um estudo transversal realizado na UTI de adultos do Hospital Universit?rio Onofre Lopes. A amostra final foi constitu?da de 206 pacientes. Para coleta de dados utilizou-se um instrumento composto por vari?veis pertinentes aos dados sociodemogr?ficos, cl?nicos e fatores de risco do DE em estudo. A infer?ncia quanto ? presen?a do diagn?stico nos pacientes avaliados foi realizada por um par de enfermeiros diagnosticadores com experi?ncia em julgamento diagn?stico e em assist?ncia de enfermagem em UTI. Todos os dados coletados foram organizados e armazenados em um banco de dados constru?do no programa Statistical Package for Social Science (SPSS) vers?o 22.0 para teste. Para a an?lise descritiva, foram consideradas as frequ?ncias, medidas do centro da distribui??o e suas variabilidades. Para comparar m?dias, aplicou-se o teste t de Student para amostras independentes. Em caso de assimetria, o teste de Mann-Whitney foi utilizado. Para medidas associativas, utilizou-se o teste Qui-quadrado de Pearson e quando as frequ?ncias esperadas foram menores que cinco, foi aplicado o teste de Fisher. A magnitude da associa??o foi verificada por meio da raz?o de preval?ncia. Este estudo obteve parecer favor?vel do Comit? de ?tica em Pesquisa da Universidade Federal do Rio Grande do Norte e ? financiado pelo Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico - CNPq, processo n? 444290/2014-1. Dos 206 pacientes, 52,4% eram do sexo masculino, idade m?dia de 58,41 anos e 57,6% residiam no interior do Rio Grande do Norte. Em rela??o ? escolaridade, a maioria (40,3%) tinha ensino fundamental incompleto e 43,3% eram aposentados. De acordo com o tipo de interna??o, 49% foram cl?nicas, 29,1% cirurgias de urg?ncia/emerg?ncia e 21,8% cirurgias eletivas. Das comorbidades, 59,7% apresentavam hipertens?o arterial sist?mica e 31,6% diabetes mellitus. 47,6% dos pacientes apresentaram o DE em estudo. Desta forma, 52,4% j? apresentaram o diagn?stico cl?nico de ressecamento ocular. Na an?lise por olho, 56,8% apresentaram o DE, j? o ressecamento ocular esteve presente em 43,2% dos olhos. Os fatores de risco mais prevalentes foram: fatores ambientais e regime de tratamento (100%), terapia com ventila??o mec?nica (52,4%), envelhecimento (51%), les?es neurol?gicas com perda sensorial reflexo motora (50%), sexo feminino (47,6%) e estilo de vida (36,4%). Apresentaram associa??o estatisticamente significante com a presen?a do DE estudado no olho direito (OD) a aus?ncia das seguintes caracter?sticas cl?nicas: motivo de interna??o por dist?rbio gastrointestinal, lagoftalmia no OD, lagoftalmia no olho esquerdo (OE), hiperemia do OE, secre??o mucosa OD, edema palpebral OD, proptose OD e uso de anti-inflamat?rio. A presen?a da hiperemia no OD foi significativa para aus?ncia do DE no OD. A diferen?a de m?dias do schirmer no OD e OE entre a presen?a e aus?ncia do DE no OD tamb?m apresentaram signific?ncia. Em rela??o ao OE, existiu associa??o estatisticamente significante entre o reflexo c?rneo-palpebral do OD e DE risco de olho seco do OD com a presen?a do DE no OE. Al?m disso, as aus?ncias de outras caracter?sticas cl?nicas apresentaram-se significativas com a presen?a do DE no OE: hiperemia OD e OE, edema palpebral OD e OE, secre??o mucosa OE, uso de bloqueadores neuromusculares e ressecamento ocular no OD e OE. Ainda, o schirmer do OD e OE apresentaram diferen?as de m?dias significativas entre a presen?a e aus?ncia do DE no OE. Em rela??o ? an?lise do ressecamento ocular no OD,a aus?ncia de determinadas caracter?sticas cl?nicas foram estatisticamente significantes para a aus?ncia do ressecamento no OD, a saber: motivo de interna??o por dist?rbio gastrointestinal, lagoftalmia no OD e OE e ressecamento ocular no OE. A presen?a de hiperemia no OD apresentou signific?ncia com a presen?a no ressecamento no OD. Contudo, a aus?ncia da hiperemia no OE mostrou associa??o com a aus?ncia do ressecamento ocular no OD, assim como a secre??o mucosa no OD, edema palpebral OD, proptose OD e uso de anti-inflamat?rio. A presen?a do DE no OD e OE demonstraram associa??o com a aus?ncia do ressecamento ocular no OD. A diferen?a de m?dias do schirmer do OD apresentou rela??o significativa entre a presen?a e aus?ncia do ressecamento ocular no OD, assim como a diferen?a de m?dias dos postos do schirmer do OE. No que concerne ao ressecamento ocular no OE, a presen?a do reflexo c?rneo-palpebral no OD e DE no OD e OE apresentaram rela??o estatisticamente significativa com a aus?ncia do ressecamento ocular no OE. A hiperemia ocular presente no OD e o ressecamento do OE tamb?m demonstraram associa??o. No entanto, a aus?ncia de hiperemia ocular no OE, secre??o mucosa no OE, edema palpebral no OD e OE e o n?o uso de bloqueadores neuromusculares associaram-se significativamente com a aus?ncia do ressecamento ocular no OE. Al?m do mais, como nos demais desfechos existiram diferen?as de m?dias significativas do schirmer OD e OE entre quem apresenta ou n?o ressecamento ocular no OE. Destarte, o conhecimento obtido apresenta estimada relev?ncia no sentido de garantir uma a??o direcionada para a preven??o do ressecamento ocular em pacientes internados em UTI. / This study aimed to identify the Nursing Diagnosis (ND) Dry Eye Risk NANDA-International and ocular dryness in adult patients admitted into the Intensive Care Unit (ICU). This is a cross-sectional study done into the adult ICU of the University Hospital Onofre Lopes. The final sample consisted of 206 patients. An instrument composed of related variables to the sociodemographic data, clinical and risk factors in the study was used for data collection. Inference for the presence of the diagnosis in the patients was performed by nurse diagnosticians. All data collected were organized and stored in a database built by the Statistical Package for Social Sciences (SPSS) version 22.0 for testing. For the discriptive analysis, frequency, measures of the destribution center and it?s variabilities were considered. To compare means, the Student t test was applied for independent samples. In the case of asymmetry, the Mann-Whitney test was used. For associative measurements, Pearson's chi-squared test was used, and when the expected frequencies were lower than five, Fisher's test was applied. The magnitude of the association was verified by the prevalence ratio. This study was approved by the Ethics Committee of the Federal University of Rio Grande do Norte and is funded by the National Scientific and Technological Development Council - CNPq, process n ? 444290 / 2014-1. Of the 206 patients, 52.4% were male, the mean age was 58.41 years and 57.6% lived in the countryside of Rio Grande do Norte. According to the type of hospitalization, 50.5% were surgical (27.7% emergency surgery / emergency and elective surgery 22.8%) and 49.5% were clinics. About comorbidities, 59.7% had hypertension and 31.6% diabetes mellitus. Of the total sample, 47.6% of patients showed the ND in the study. Thus, 52.4% have had a clinical diagnosis of ocular dryness. In the analysis by eye, 56.8% had the ND, while ocular dryness was present in 43.2% of the eyes. The most prevalent risk factors were: environmental factors and treatment regimen (100%), mechanical ventilation therapy (52.4%), aging (51.0%), neurological lesions with sensory motor reflex loss (50.0%), female gender (47.6%) and lifestyle (36.4%). The absence of the following clinical features showed statistically significant association with the presence of ND studied in the right eye (RE): gastrointestinal disorder as the main reason for the hospitalization, lagophthalmos in the RE, lagophthalmos in the left eye (LE), LE hyperemia, RE mucous secretion, RE eyelid edema, RE proptosis and use of anti-inflammatory. The presence of hyperemia in the RE was significant for the absence of ND in the RE. Regarding the LE, there was a statistically significant association between corneal-palpebral reflex RE with the ND's presence in the LE. Moreover, the absence of other clinical characteristics was significant to the ND's presence in the LE: LE hyperemia, RE and LE eyelid edema, LE mucous secretion and use of neuromuscular blockers. Still, there was a significant relationship between the presence of hyperemia in the RE, and the absence of ND in the LE. Regarding the analysis of ocular dryness in the RE, the absence of certain clinical characteristics was statistically significant for the absence of dryness in the RE like gastrointestinal disorder as the reason for the hospitalization, lagophthalmos in the RE and LE, hyperemia in LE, mucous secretion in RE, RE eyelid edema, RE proptosis and use of anti-inflammatory. However, the presence of hyperemia in the RE showed meaning to the presence in the dryness of the RE. Concerning ocular dryness in the LE, the presence of corneal-palpebral reflex in RE showed a statistically significant relationship with the absence of ocular dryness in LE. Ocular hyperemia present in RE and dryness in the LE also showed association. Nevertheless, the absence of ocular hyperemia in LE, mucous secretion in the LE, eyelid edema in RE and LE and the non use of neuromuscular blockers were significantly associated with the absence of ocular dryness in LE. The difference among Schirmers posts? means in the RE and LE showed significant relation between the presence and the ausence of the ND and ocular dryness in the RE and LE. The magnitude of the association demonstrates that the presence of ND in the RE is almost four times greater for the presence of ND in the LE. Thus, the knowledge gained has valued relevance when it comes to ensure an action directed to the prevention of ocular dryness in ICU patients.
180

Aspectos t?cnico-interpretativos nas ?Tr?s Tocatas Armoriais? para viol?o solo de Danilo Guanais: novos caminhos da m?sica armorial

Pereira, Jos? Paulo 13 December 2016 (has links)
Submitted by Automa??o e Estat?stica (sst@bczm.ufrn.br) on 2017-03-14T23:45:33Z No. of bitstreams: 1 JosePauloPereira_DISSERT.pdf: 8755492 bytes, checksum: 72b01ef3023ef3d9a52f1298b6542b50 (MD5) / Approved for entry into archive by Arlan Eloi Leite Silva (eloihistoriador@yahoo.com.br) on 2017-03-16T22:40:28Z (GMT) No. of bitstreams: 1 JosePauloPereira_DISSERT.pdf: 8755492 bytes, checksum: 72b01ef3023ef3d9a52f1298b6542b50 (MD5) / Made available in DSpace on 2017-03-16T22:40:28Z (GMT). No. of bitstreams: 1 JosePauloPereira_DISSERT.pdf: 8755492 bytes, checksum: 72b01ef3023ef3d9a52f1298b6542b50 (MD5) Previous issue date: 2016-12-13 / Este trabalho trata de um estudo dos aspectos t?cnico-interpretativos da obra ?Tr?s Tocatas Armoriais?, do compositor potiguar Danilo Guanais (1965- ). As ?Tr?s Tocatas Armoriais? ? uma obra para viol?o solo dividida em tr?s movimentos, O Romance do Boi da M?o de Pau, Poema Negro e O Admir?vel V?o do Pav?o Misterioso, constru?da, segundo Guanais, sob uma concep??o atualizada da M?sica Armorial. Objetivando entender o que seria a ?vers?o atualizada da M?sica Armorial?, como afirma o compositor, procuramos apresentar uma contextualiza??o da M?sica Armorial que vai desde sua produ??o inicial, com os prim?rdios do Movimento Armorial, at? a produ??o dessa m?sica por compositores atuais que se prop?e compor M?sica Armorial utilizando elementos e procedimentos da m?sica do s?culo XX e XXI. No presente trabalho apresentamos, tamb?m, uma breve discuss?o sobre a dicotomia de concep??o instaurado por Ariano Suassuna e Cussy de Almeida e a contribui??o gerada, atrav?s dessa dualidade de pensamentos, para a produ??o posterior da M?sica Armorial. Foram utilizadas na metodologia entrevista com o compositor, an?lise e estudo da obra, bem como referenciais te?ricos como Santos (2009), Marinho (2010), Queiroz (2014), e outros. Tem-se como objetivo apresentar elementos que propiciem ao int?rprete execut?-la o mais pr?ximo poss?vel da concep??o do compositor a partir das ideias expostas pelo mesmo. Como resultados apresentamos informa??es sobre a concep??o apresentada pelo compositor, n?o propondo uma discuss?o aprofundada da quest?o, onde o mesmo afirma produzir suas obras a partir de elementos que se caracterizam como uma ?vers?o atualizada da M?sica Armorial?. Apresentamos, no ?ltimo cap?tulo, os materiais que foram utilizados para a constru??o da obra, como por exemplo as literaturas que o motivaram na produ??o das pe?as; os elementos filos?ficos presentes na obra ?Tr?s Tocatas Armoriais?, principalmente no ?ltimo movimento, O V?o Admir?vel do Pav?o Misterioso, que sugere a imag?tica de uma m?quina tentando al?ar v?o. Apresentamos, tamb?m, a an?lise do material mel?dico, utiliza??o da nota pedal, caracter?stica presente na m?sica dos violeiros utilizados na M?sica Armorial, bem como sugest?es t?cnico-interpretativas da obra. / This paper is a study about the technical-interpretative aspects in ?Tr?s Tocatas Armoriais,? whose author is the Potiguar Danilo Guanais (1965 ?). ?Tr?s Tocatas Armoriais? is a work for solo guitar and is divided into three movements: Romance do Boi da M?o de Pau, Poema Negro and O Admir?vel V?o do Pav?o Misterioso. It was made, according to Guanais, under the updated conception of Armorial Music. In order to understand what is the "updated version of Armorial Music", as the composer says, we tried to present a contextualization of Armorial Music, since its initial production, with the beginnings of the Armorial Movement, until the production of the song by current composers who proposed to compose Armorial Music using elements and procedures of 20th and 21st century music. We also present a brief discussion about the dichotomy of conception established by Ariano Suassuna and Cussy de Almeida, and its contribution, with the duality of thoughts, for the later production of Armorial Music. In methodology it was used an interview with de composer, analysis and study of the work, and some references as Santos (2009), Marinho (2010) and Queiroz (2014). The aim of this paper is to show elements that enable the interpreter to perform it as close as possible to the composer's conception. As results we present information about the conception presented by the composer, without in-depth discussion, in which the author affirms to produce his works from elements that are characterized as an "updated version of Armorial Music.? The materials used for the construction of the work are presented at the last chapter and were the literatures that motivated the coposer in the production of the plays; the philosophical elements present in ?Tr?s Tocatas Armoriais?, especially in the last movement, O V?o Admir?vel do Pav?o Misterioso, which suggests the imagery of a machine trying to fly. It was also presented an analysis of the melodic material, the application of the pedal note, which is a characteristic of the music of the guitar players used in Armorial Music, and some technical-interpretative suggestions of the work.

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