Submitted by Etelvina Domingos (etelvina.domingos@ufpe.br) on 2015-04-15T17:53:25Z No. of bitstreams: 2 DISSERTAÇÃO Marcos Antonio Filho.pdf: 14345264 bytes, checksum: 768b2b81f02e6b4c742442a4fcaa1fbc (MD5) license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) / Made available in DSpace on 2015-04-15T17:53:25Z (GMT). No. of bitstreams: 2 DISSERTAÇÃO Marcos Antonio Filho.pdf: 14345264 bytes, checksum: 768b2b81f02e6b4c742442a4fcaa1fbc (MD5) license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) Previous issue date: 2014-07-31 / Esta dissertação explora o design de hiperlivros para tablets e investiga a utilização desta hipermídia como ferramenta educacional. Neste sentido, o estudo colabora para o avanço do estado da arte tecnológico dos livros didáticos ao produzir, como resultado de uma pesquisa baseada na prática, um hiperlivro paradidático. Em 1 ano, o hiperlivro Amazônia foi baixado 5 mil vezes, e sua prática projetual subsidiou construções teóricas necessárias para o desenvolvimento do conhecimento em design. A pesquisa conclui que os hiperlivros são uma proposta inovadora para o design de livros didáticos, pois superam antigas limitações dos livros impressos, tais como a possibilidade de atualizar o conteúdo, a visualidade ampliada, interatividade e acessibilidade. Bem como, validou-se a utilização dos hiperlivros em tablets como recursos didáticos, ao evidenciar que esta hipermídia pode melhorar a aprendizagem, motivar os alunos, facilitar sua compreensão e aumentar seu interesse pela disciplina. O estudo indica quais métodos e recursos de design devem ser aplicados a fim de atingir melhores resultados.!

Ingeniero Civil en Computación / Este trabajo consiste en el desarrollo de una aplicacion para tablets complementaria a la labor educativa en la enseñanza de la lectura. Este informe presenta el diseño, desarrollo y resultados de validación del proyecto. La lectura es algo fundamental en la sociedad, leer otorga a una comunidad más cultura para sus participantes. La enseñanza de este proceso ocurre, generalmente, en edades tempranas, donde los niños deben buscar una motivación que puede ser esquiva o no inducida. La tecnología llama la atención en lo más pequeños, por lo que puede ser usado como método para llegar a ellos de manera lúdica, pero con contenido pedagógico. Se plantea, como hipótesis, que la tecnología sirve de apoyo para la enseñanza de la lectura, facilitando su aprendizaje como incentivo a la motivación. Para esto se desarrolló una aplicación en tablets con sistema operativo Android que permite al usuario interactuar, de distintas formas, con las letras. Cada actividad planteada utiliza los gestos provistos por los dispositivos con pantalla táctil, de manera de diversificar las opciones de juegos. El estudio realizado en niños de entre 4 a 5 años concluyó que la aplicación desarrollada es simple y del gusto de los usuarios, permite aprender y ejercitar las letras del abcedario de manera efectiva, pero el tiempo dedicado a las pruebas de usuarios no es concluyente en la comprobación de un aprendizaje completo, debido al tiempo que demora el proceso de aprender a leer. La aplicación puede ser utilizada como una herramienta de apoyo sin ningún problema.

The present study examined whether the exposure to likeable characters and educational content would affect the attitudes and behaviors of children after playing an educational children's game. The parasocial interaction (PSI) experienced by children was measured between children playing an educational game with interactive characters and those children who watched videos with the same character. This study also investigated the presence of mediated scaffolding provided by the interactive character in the educational game. A three group between subjects experimental design was employed. Subjects were randomly assigned to play an educational game, watch a video, or color on a tablet for 10 minutes. They were asked a series of questions about their experience on the tablet and the interaction with the character and then offered an educational prize or non-educational prize at the end. This study found that children in both the educational game and video condition reported experiencing a PSI with the character Alpha-Pig. Additionally, it was found that when kindergarteners were exposed to the educational game and the educational video, they chose an educational reward more often than the control group. This study also found that with this particular age group and the use of tablets, there were many findings that were impacted by a ceiling effect: children in all groups scored high on the educational worksheet and showed high levels of motivation for current and future learning. These findings support past PSI research, showing that children are experiencing a PSI while interacting with a likeable character in an educational game. Additionally, this study adds to the understanding of scaffolding, extending its effects from only personal interactions to mediated interactions. Ultimately, this study helps parents and teachers to understand the importance of likeable characters in educational games for children.

The 40 kg melt was degassed by two methods: Immersion of a degassing tablet in a melt by an immersion bell and an argon degassing through a lance with a porous plug. Up-gassing tablets were also used during the experiment. The method of double weighing was used for evaluation. No technically significant degassing was achieved using degassing tablets. After degassing with tablets was observed a decrease in DI (Dichte Index) value with increasing residence time. Excessive dosing of the tablet does not ensure a higher degassing effect, it only ensures a higher turbulence of the reaction. Preheating the degassing tablets before use does not affect degassing. By preheating the up-gassing tablets, their reactivity is reduced. Two immersion bells with different proportions were tested. The bells do not ensure a homogeneous dispersion of bubbles in the melt. By argon degassing through the porous plug, the melt was degassed to a value DI = 1,87 %. The consumption of argon for degassing smaller amounts of melt is higher than for degassing larger amounts of melt. Argon refining is more efficient than using tablets.

Drying procedures, like other important unit operations in pharmacy, have received little attention in pharmaceutical literature. Within recent years, however, growing interest in these pharmaceutical engineering areas has become apparent. Fluidization operations, although relatively unexplored in pharmacy, have been firmly established on a broad scale in other industries. Fluidization may be defined as the suspension and agitation of a bed of particulate solids by a vertically rising stream of gas. Each suspended particle is surrounded by the gas. This relative velocity of the gas and solid particles is high, although the gas velocity itself is relatively low. Heat is transferred by by a combination of conduction and convection and by the movement of the solid particles (1). Fluidized bed drying of moist phosphate rock, coal, and many other materials has been discussed in technical literature (1, 2). However, relatively few reports have appeared on the applications of fluidized beds to materials of pharmaceutical interest. These technical studies show that uniform bed temperatures with high heat and mass transfer rates are obtainable in fluidization system. Product temperatures are controllable over narrow limits within the fluidized bed. These reported advantages would appear to have particular importance in processing pharmaceuticals. It is difficult to understand, therefore, why only a few studies on fluidized bed drying have appeared in pharmaceutical literature. Apparently no comprehensive studies dealing with finished tablets, compressed from granulations dried by the fluidization technique, have appeared in pharmaceutical literature. Accordingly, it would seem appropriate that more studies be conducted, in pharmaceutical fields, concerning drying procedures, especially the fluidization process. The present project will consist of conducting a series of tests on identical granule formulations dried by the conventional air drying and oven drying processes as well as the fluidized bed drying technique. The present work will also include the performance of tests on specific physical properties of tablets compressed from the test granulations.

Lactobacilli are dominant bacteria of the vaginal flora. Lactobacillus-containing probiotics products are used for the treatement and profylaxis of bacterial urogenital infections. This work is focused on DNA identification and species identification of probiotic bacteria in 5 different vaginal tablets using molecular-genetic methods. Total DNA isolated from complex matrix of vaginal tablets was used for amplification in polymerase chain reaction. DNA was isolated from crude cell lysates by magnetic particles P(HEMA-co-GMA) and by method of phenol extraction. Identification of species of probiotic bacteria was verified using genus-specific and species-specific PCRs. Results of bacterial identification obtained by PCR were compared with declared specification given by producers. Bacteria of genus Lactobacillus were proved in all tablets whereus species identification was in accordance with the stated composition in 1 tablet only.

Charles University, Faculty of Pharmacy in Hradec Králové Department of: Pharmaceutical Technology Supervisor: Consultants: Assoc. Prof. PharmDr. Zdeňka Šklubalová, Ph.D. Mgr. Jana Brokešová, Mgr. Daniel Pěček Student: Miroslav Ouzký Title of Thesis: Study of excipientsʼ influence on the drug dissolution from tablets The aim of this work was to study the influence of excipients on the dissolution of the high-dose active substance from tablets. The tablets were compressed from the granules prepared by wet-granulation method. 11 batches of tablets which contained two different fillers: either lactose or microcrystalline cellulose, respectively; and extragranularly added disintegrant: either croscarmellose or crospovidone, respectively, in three concentration levels of 2 %, 3,7 % or 5,4 % were prepared. Tablets were packed into aluminium/PVC blisters. The paddle dissolution test was used to determine the release of the active substance into phospate buffer pH 7,2 at the time of preparation (time 0) and at the time points 1.5, 3 and 6 months of stability assay at 40 řC and 75 % relative air humidity. The results show that the drug release from tablets containing microcrystalline celulose was generally faster than from those containing lactose. The same was true for tablets to which croscarmellose was...

Charles University, Faculty of Pharmacy in Hradci Králové Department of: Supervisor: Pharmaceutical Technology doc. PharmDr. Zdeňka Šklubalová, Ph.D. Consultant: Mgr. Jana Brokešová Student: Daniela Ferechová Title of Thesis: Study of the influence of tablet mixture composition on the flow and consolidation properties Good flow properties of a tabletting mixture play an important role in the manufacturing of tablets. Flow behaviour of the commercial (original) tabletting mixture with poor flowability was evaluated in this thesis. The main aim was to find alternative fillers that may improve its flow. The granulometric characteristics and flowability of eight types of lactose and microcrystalline cellulose and their binary mixtures were studied. In comparison to the original tabletting mixture, the proposed modified one with both original fillers were replaced with new ones showed significantly better flow properties with steady state flow through the hopper orifice having a diameter of 10 mm. The results were confirmed using powder rheometer. The lower shear stress necessary to achieve flow under different normal loads as well as approximately 72 times lower cohesion value were detected for the modified tabletting mixture.

Learning in the classroom can occur as a combination of students' personal effort to study class material, the instructor's attempt to present class material, and the interaction that takes place between instructor and students. In a more traditional setting, instructors can lecture by writing notes on a chalkboard or a whiteboard. If instructors want to display prepared lecture slides, they can use the overhead projector and write additional notes on top of these overhead transparencies. With many technological advances, various researchers are advocating towards integration between technology and learning. With the advent of tablet PCs, researchers recognize the potential usefulness of its functions within the classroom. Not only can electronic materials be presented via the computer, tablet PCs allow instructors to handwrite notes on top of the slides, mimicking manual devices such as the overhead. Even though the use of tablet PCs can be advantageous to instructors and students, no research found so far has focused on the issue of how well tablet PC features address varying learning styles of students (e.g. visually oriented vs. text-based learning). According to Felder, "understanding learning style differences is thus an important step in designing balanced instruction that is effective for all students” [22]. Hence, this research explores the correlation between tablet-based presentation systems and learning styles by taking two approaches: performing a pilot study and distributing a survey. The results from these approaches are evaluated to yield statistically significant conclusions on how well tablet-based presentation systems encompass the different learning needs of student.

Pharmaceutical tablets have been the most dominant form for drug delivery and they need to be strong enough to withstand external stresses due to packaging and loading conditions before use. The strength of the produced tablets, which is characterised by their compressibility and compactibility, is usually deter-mined through a physical prototype. This process is sometimes quite expensive and time consuming. Therefore, simulating this process before hand can over-come this problem. A technique for shape modelling of pharmaceutical tablets based on the use of Partial Differential Equations is presented in this thesis. The volume and the sur-face area of the generated parametric tablet in various shapes have been es-timated numerically. This work also presents an extended formulation of the PDE method to a higher dimensional space by increasing the number of pa-rameters responsible for describing the surface in order to generate a solid tab-let. The shape and size of the generated solid tablets can be changed by ex-ploiting the analytic expressions relating the coefficients associated with the PDE method. The solution of the axisymmetric boundary value problem for a finite cylinder subject to a uniform axial load has been utilised in order to model a displace-ment component of a compressed PDE-based representation of a flat-faced round tablet. The simulation results, which are analysed using the Heckel model, show that the developed model is capable of predicting the compressibility of pharmaceutical powders since it fits the experimental data accurately. The opti-mal design of pharmaceutical tablets with particular volume and maximum strength has been obtained using an automatic design optimisation which is performed by combining the PDE method and a standard method for numerical optimisation.