<p>Gravitational waves and electromagnetic waves are important as carriers of energy and information. This thesis is devoted to the study of the propagation and interaction of these waves in plasmas, with emphasis on nonlinear effects and applications within astrophysics.</p><p>The physical systems are described by the Einstein-Maxwell-fluid equations or Einstein-Maxwell-Vlasov equations, when a kinetic treatment is required. The small amplitude and high-frequency approximation is employed for the gravitational waves, such that perturbative techniques can be applied and space-time can be considered locally flat, with a gravitational radiation field superimposed on it. The gravitational waves give rise to coupling terms that have the structure of effective currents in the Maxwell equations and an effective gravitational force in the equation of motion for the plasma. The Einstein field equations describe the evolution of the gravitational waves, with the perturbed energy-momentum density of the plasma and the electromagnetic field as a source.</p><p>The processes that are investigated are gravitational waves exciting electromagnetic waves in plasmas, altering the optical properties of plasmas and accelerating charged particles. The thesis also deals with the propagation propertities of gravitational and electromagnetic waves, e.g. effects due to resonant wave-particle interactions, plasma inhomogeneties and nonlinear self-interactions. It is also shown that plasmas that are not in thermodynamical equilibrium may release their free energy by emitting gravitational waves.</p>

<p>Networks are all around us, all the time. From the biochemistry of our cells to the web of friendships across the planet. From the circuitry of modern electronics to chains of historical events. A network is the result of the forces that shaped it. Thus the principles of network formation can be, to some extent, deciphered from the network itself. All such information comprises the structure of the network. The study of network structure is the core of modern network science. This thesis centres around three aspects of network structure: What kinds of network structures are there and how can they be measured? How can we build models for network formation that give the structure of networks in the real world? How does the network structure affect dynamical systems confined to the networks? These questions are discussed using a variety of statistical, analytical and modelling techniques developed by physicists, mathematicians, biologists, chemists, psychologists, sociologists and anthropologists. My own research touches all three questions. In this thesis I present works trying to answer: What is the best way to protect a network against sinister attacks? How do groups form in friendship networks? Where do traffic jams appear in a communication network? How is cellular metabolism organised? How do Swedes flirt on the Internet? . . . and many other questions.</p>

<p>The overall aim of this thesis is to compare different methods for calculation of Core-Level shifts in metallic alloys. The methods compared are the Initial State model, the Complete screening and the Transition state model. Core-level shifts can give information of chemical bonding and about the electronic structure in solids.</p><p>The basic theory used is the so-called Density-Functional-Theory, in conjunction with the Local-Density Approximation and the Coherent-Potential- Approximation. The metallic alloys used are Silver-Palladium, Copper-Palladium, Copper-Gold and Copper-Platinum, all inface-centered-cubic configuration.</p><p>The complete screening- and the transition-state model are found to be in better agreement with experimental results than those calculated with the initial state model. This is mainly due to the fact that the two former models includes final-state effects, whereas the last one do not. The screening parameters within the Coherent-Potential approximation are also investigated. It is found that the Screened-Impurity Model can extend the validity of the Coherent-Potential-Approximation and increase it's accuracy.</p>

<p>Denna uppsats undersöker den kvantitativa och den kvalitativa forskningsmetoden ur ett kunskapsteoretiskt och ett vetenskapsteoretiskt perspektiv. I fråga om kvalitativ forskning har metoderna hermeneutik och fenomenologi studerats särskilt grundligt. Uppsatsen argumenterar för att kunskapsteoretiska och vetenskapsteoretiska antaganden måste vara gemensamma för de båda typerna av metod, om man anser att båda typerna ska betraktas som vetenskapliga. Vidare hävdas att de kvalitativa metoderna är sammankopplade med en rad problem beträffande objektivitet, generaliserbarhet, rättfärdigande av kunskap och teoriers empiriska stöd. I många fall utger sig dessa metoder för att leva upp till de krav man ställer på vetenskaplig forskning i dessa avseenden i lika hög grad som kvantitativ metod, men en av uppsatsens teser är att de misslyckas med detta. I uppsatsen hävdas att vetenskapens mål är att generera generaliserbar kunskap. På grund av de kunskapsteoretiska problem kvalitativ forskning stöter på, kan sådan forskning inte ensam nå detta mål och således inte ha någon självständig plats i vetenskapen, utan kan endast tjäna ett förvetenskapligt syfte, genom att, i vissa fall, formulera frågor och hypoteser som sedan besvaras respektive testas av kvantitativ forskning.</p> / <p>This paper examines the quantitative and the qualitative research methods with respect to both epistemology and the philosophy of science. With regards to qualitative research, the paper takes a closer look at the hermeneutic and the phenomenological methods in particular. The paper argues that the different types of method must have the same epistemological assumptions, if it is held that both types ought to be considered scientific. It is further claimed that the qualitative methods are connected to several problems concerning objectivity, generalizability, the justification of knowledge and the empirical support of theories. In many cases, these methods purport to live up to the requirements that are made on scientific research in these respects to the same degree as the quantitative method, but one of the theses of this paper is that they fail to do this. In the paper, it is maintained that the goal of science is to generate generalizable knowledge. Due to the epistemological problems qualitative research are faced with, such research cannot reach that goal alone and thus cannot hold an independent position in science, but can only serve a prescientific purpose, by, in some cases, drawing up questions and hypotheses which are then answered and tested respectively, by quantitative research.</p>

<p>This thesis describes some aspects of noncommutative geometry and conformal field theory. The motivation for the investigations made comes to a large extent from string theory. This theory is today considered to be the most promising way to find a solution to the problem of unifying the four fundamental interactions in one single theory. The thesis gives a short background presentation of string theory and points out how noncommutative geometry and conformal field theory are of relevance within the string theoretical framework. There is also given some further information on noncommutative geometry and conformal field theory. The results from the three papers on which the thesis is based are presented in the text. It is shown in Paper 1 that, for a gauge theory in a flat noncommutative background only the gauge groups <i>U(N)</i> can be used in a straightforward way. These theories can arise as low energy limits of string theory. Paper 2 concerns boundary conformal field theory, which can be used to describe open strings in various backgrounds. Here different orbifold theories which are described using simple currents of the chiral algebra are investigated. The formalism is applied to ``branes´´ in <b>Z</b>₂<b> </b>orbifolds of the <i>SU(2)</i> WZW-model and to the <i>D</i>-series of unitary minimal models. In Paper 3 two different descriptions of an invariant star-product on <i>S²</i> are compared and the characteristic class that classifies the star-product is calculated. The Fedosov-Nest-Tsygan index theorem is used to compute the characteristic class.</p>

The extensions of vague predicates like ‘is bald’, ‘is tall’, and ‘is a heap’ apparently lack sharp boundaries, and this makes such predicates susceptible to soritical reasoning, i.e. reasoning that leads to some version of the notorious sorites paradox. This essay is concerned with a certain kind of theory of vagueness, according to which the symptoms and puzzles of vagueness should be accounted for in terms of a particular species of context sensitivity exhibited by vague expressions. The basic idea is that the extensions of vague predicates vary with certain contextual factors, and that this fact can explain why they appear to lack sharp boundaries. This kind of view is referred to as contextualism about vagueness. A detailed characterisation of contextualism about vagueness is given in chapter two and three. In chapter two, a generic version of contextualism about vagueness is developed, and some alternative forms of context sensitivity are introduced. In chapter three, the specific contextual factors appealed to by different contextualists are discussed. In chapter four, different contextualist diagnoses of the sorites paradox are considered, and found to be problematic in various ways. It is argued that contrary to what some of its proponents have claimed, contextualism about vagueness is not superior to other comparable theories of vagueness when it comes to explaining the appeal of soritical reasoning. In chapter five, a certain version of the sorites paradox, known as the forced march sorites, is discussed. It is argued that “data” about how speakers would behave in the forced march cannot lend any firm support to contextualism about vagueness. In chapter six, some problems concerning the instability of the contextual factors are considered. One problem is that contextualist diagnoses of the sorites which locate a fallacy of equivocation in the reasoning seem to render non-soritical reasoning fallacious as well. A model for treating this problem is suggested, but on closer consideration, it turns out to be problematic. Moreover, this model is of no help in solving the more general problem that even if classical logic remains valid for vague language on some contextualist views, the instability of the extensions of vague predicates makes it difficult to know when a certain piece of reasoning instantiates a valid argument form. Other difficulties arise with respect to speech reports and belief contents. Chapter seven concludes with a summary and some methodological remarks.

The increased use of the diesel engine in the passenger car, truck and bus market is due to high efficiency and lower fuel costs. This growing market share has brought with it several environmental issues for instance soot particle emission. Different technologies to remove the soot have been developed and are normally based on some kind of soot trap. In particular for automobiles the use of diesel particulate traps or filters (DPF:s) based on ceramic monolithic honeycombs are becoming a standard. This new exhaust system component will affect the acoustics and also work as a muffler. To properly design exhaust systems acoustic models for diesel particulate traps are needed. The first part of this thesis considers the modelling of sound transmission and attenuation for traps that consist of narrow channels separated by porous walls. This work has resulted in two new models an approximate 1-D model and a more complete model based on the governing equations for a visco-thermal fluid. Both models are expressed as acoustic 2-ports which makes them suitable for implementation in acoustic software for exhaust systems analysis. The models have been validated by experiments on clean filters at room temperature with flow and the agreement is good. In addition the developed filter models have been used to set up a model for a complete After Treatment Device (ATD) for a passenger car. The unit consisted of a chamber which contained both a diesel trap and a Catalytic Converter (CC). This complete model was also validated by experiments at room temperature. The second part of the thesis focuses on experimental techniques for plane wave decomposition in ducts with flow. Measurements in ducts with flow are difficult since flow noise (turbulence) can strongly influence the data. The difficulties are also evident from the lack of good published in-duct measurement data, e.g., muffler transmission loss data, for Mach-numbers above 0.1-0.2. The first paper in this part of the thesis investigates the effect of different microphone mountings and signal processing techniques for suppressing flow noise. The second paper investigates in particular flow noise suppression techniques in connection with the measurement of acoustic 2-ports. Finally, the third paper suggests a general wave decomposition procedure using microphone arrays and over-determination. This procedure can be used to determine the full plane wave data, e.g., the wave amplitudes and complex wave numbers k+ and k-. The new procedure has been applied to accurately measure the sound radiation from an unflanged pipe with flow. This problem is of interest for correctly determining the radiated power from an engine exhaust outlet. The measured data for the reflection coefficient and end correction have been compared with the theory of Munt [33] and the agreement is excellent. The measurements also produced data for the damping value (imaginary part of the wavenumber) which were compared to a model suggested by Howe [13]. The agreement is good for a normalized boundary layer thickness less than 30-40

Though generally recognized as a formative force in his philosophy, Thomas Reid’s Newtonianism and his philosophy of science has not received due attention among scholars. My aim is to inaugurate a detailed survey. In ch. 1 it is shown that Reid demarcates physics as against metaphysics and theology, making his brand of Newtonianism different from first generation moral and religious Newtonianism. In ch. 2 it is argued that "Newtonian" is not an apt label on Reid’s call for a Science of the human mind. Neither his practice within the field, nor his methodological views, make lawlike connections the central kind of truth to be discovered. Ch. 3 is devoted to Reid’s account of the 1st and 2nd of Newton’s Regulae Philosophandi, and an ensuing notion of explanation which approaches the deductive-nomological model. It is shown that Reid’s account is very much his own, though presented as an explication of Newton’s intentions. Reid’s dismissive view towards simplicity as a guide in scientific reasoning leans on Bacon’s theory of idols and Reid’s theory of first principles of common sense. Ch 4 concerns hypotheses in connection with Newton’s phrase Hypotheses non fingo. It is argued that Reid does not mind speculation about unobservable or theoretical entities, and that his objections to particular ether theories are scientific rather than principled. Nonetheless, since Reid does not explain the difference between powerful conjecture and established truth, his notion of scientific reasoning remains elusive. Ch 5 concerns Reid’s views on the concept and ontology of forces of attraction. It is argued that Reid takes forces to be physical entities open for empirical enquiry, and that forces are neither active, nor efficient. Finally, Reid’s view of metaphysics is considered, and further differences with early Newtonians emphasised.

Gravitational waves and electromagnetic waves are important as carriers of energy and information. This thesis is devoted to the study of the propagation and interaction of these waves in plasmas, with emphasis on nonlinear effects and applications within astrophysics. The physical systems are described by the Einstein-Maxwell-fluid equations or Einstein-Maxwell-Vlasov equations, when a kinetic treatment is required. The small amplitude and high-frequency approximation is employed for the gravitational waves, such that perturbative techniques can be applied and space-time can be considered locally flat, with a gravitational radiation field superimposed on it. The gravitational waves give rise to coupling terms that have the structure of effective currents in the Maxwell equations and an effective gravitational force in the equation of motion for the plasma. The Einstein field equations describe the evolution of the gravitational waves, with the perturbed energy-momentum density of the plasma and the electromagnetic field as a source. The processes that are investigated are gravitational waves exciting electromagnetic waves in plasmas, altering the optical properties of plasmas and accelerating charged particles. The thesis also deals with the propagation propertities of gravitational and electromagnetic waves, e.g. effects due to resonant wave-particle interactions, plasma inhomogeneties and nonlinear self-interactions. It is also shown that plasmas that are not in thermodynamical equilibrium may release their free energy by emitting gravitational waves.

The reaction mechanisms for the hemoglobin degrading enzymes in the Plasmodium falciparum malaria parasite, plasmepsin II (Plm II) and histo-aspartic protease (HAP), have been analyzed by molecular simulations. The reaction free energy profiles, calculated by the empirical valence bond (EVB) method in combination with molecular dynamics (MD) and free energy perturbation (FEP) simulations are in good agreement with experimental data. Additional computational methods, such as homology modelling and automated substrate docking, were necessary to generate a 3D model and a reactive substrate conformation before the reaction mechanism in HAP could be investigated. HAP is found to be an aspartic protease with a peptide cleaving mechanism similar to plasmepsin II. The major difference between these enzymes is that the negatively charged tetrahedral intermediate is stabilized by the charged histidine in HAP while in Plm II it is a neutral aspartic acid. Also the reaction mechanism for two other aspartic proteases, cathepsin D and HIV-1 protease, was simulated. These enzymes are relevant both for the inhibitor selectivity and for obtaining a general picture of catalysis in aspartic proteases. Another project involves inhibitor design towards plasmepsins. In particular, Plm II directed inhibitors based on the dihydroxyethylene scaffold have been characterized computationally. Molecular dynamics (MD) simulations were used to propagate the investigated system through time and to generate ensembles used for the calculation of free energies. The ligand binding affinities were calculated with the linear interaction energy (LIE) method. The most potent inhibitor had a Ki value of 6 nM and showed 78 % parasite inhibition when tested on red blood cells infected by malaria parasite P. falciparum. Citrate synthase is part of the citric acid cycle and is present in organisms that live in cold sea water as well as hot springs. The temperature adaptation of citrate synthase to cold and heat was investigated in terms of the difference in transition state stabilization between the psychrophilic, mesophilic and hyperthermophilic homologues. The EVB, FEP and MD methods were used to generate reaction free energy profiles. The investigated energetics points toward the electrostatic stabilization during the reaction as the major difference between the different citrate synthase homologues. The electrostatic stabilization of the transition state is most effective in the following order of the citrate synthase homologues: hyperthermophile, mesophile, psycrophile. This could be a general rule for temperature adaptation of enzyme catalysis.