Depression is a serious mental health concern affecting nearly 20% of the population (Kessler, 2002). A hallmark feature of depression is a prolonged period (i.e., 2 weeks or more) of sad mood. Because of this, recent conceptualizations have described Major Depressive Disorder as a dysfunction of emotion regulation (e.g., Kring & Bachorowski, 1999). However, the nature of this emotion regulation dysfunction in MDD is not well understood. The current study examined whether experimentally manipulating emotion regulation during a stressful task would help depressed individuals more effectively regulate subjective and physiological emotional responses. Although theorists have speculated that depression may potentiate certain emotional states, few empirical studies have been completed. One study found that depressed individuals reacted with significantly greater anger in response to a distressing and frustrating task than non-depressed individuals (Ellis, Fischer & Beevers, 2010). That study suggested that emotion regulation difficulties may contribute to the potentiation of some negative emotions, such as anger, among depressed individuals. Altering the emotion regulation strategies typically used by depressed individuals could therefore attenuate emotional reactivity to stressful experiences. Gross (1998) posits that emotion regulation can occur at two distinct points--either manipulating the input or the output of the emotional process. He refers to these as antecedent-focused (e.g., reappraisal of cognitions) or response-focused (e.g., acceptance of experience) emotion regulation. This theoretical framework provides a model through which to examine strategies to reduce distress and anger in depression. Specifically, the current dissertation examined the differential effects of manipulating an emotional response before generated (reappraisal; antecedent-focused) and after elicited (acceptance; response-focused). Depressed and non-depressed individuals were randomized to an emotion regulation strategy: reappraisal, acceptance or no strategy. They then completed a standardized, distressing task previously shown to potentiate anger (Ellis et al., 2010) and affect physiological responding (Matthews & Stoney, 1988). Subjective (i.e., anger, anxiety) and physiological (i.e., heart rate, galvanic skin response, respiration) emotional responses were collected to determine whether manipulating emotion regulation attenuates emotional reactivity to the distressing task. Results indicated that depressed individuals responded with greater anger, had lower galvanic skin conductance response, and persisted for shorter duration on the task than non-depressed individuals. Results also indicated that instructions to accept emotions increased anger during the task compared to reappraisal or no strategy. However, depression status and emotion regulation strategy did not interact, suggesting the effect of emotion regulation strategy did not differ across depression groups. Further, there were no differences between strategies for task persistence or skin conductance. Results suggest that acceptance is not an effective strategy for the acute reduction of anger. Results also emphasize the importance of anger potentiation and distress intolerance and highlight the need for continued work that identifies more effective strategies for emotion dysregulation in depression. / text

As technology continues to scale to smaller geometries and newer dimensions (3-D), with increasingly complex manufacturing processes, the ability to reliably manufacture 100% defect-free circuitry becomes a significant challenge. While implementing additional circuitry to improve yield is economically justifiable, this thesis addresses the cost of defect tolerance by providing lower cost solutions or alternatively more defect tolerance for the same cost in state-of-the-art ICs, including three-dimensional ICs (3-D ICs). Conventional defect tolerance techniques involve incorporating redundancy into the design. This thesis introduces novel designs to maximize the utility of spare elements with minimal circuitry overhead, thereby improving the yield. One idea proposed is Selective Row Partitioning (SRP), a technique which allows a single spare column to be used to repair multiple defective cells in multiple columns. This is done by selectively decoding the row address bits when generating the select signals for the column multiplexers. This logically segments the spare column allowing it to replace different columns in different partitions of the row address space. All the chips are identical, but fuses are used to customize the row decoding circuitry on a chip-by-chip basis. An implementation procedure and results are presented which show improvement in overall yield at a minimal overhead cost. Moreover, new yield-enhancing design techniques for 3-D ICs are introduced. When assembling a 3-D IC, there are several degrees of freedom including which die are stacked together, in what order, and with what rotational symmetry. This thesis describes strategies for exploiting these degrees of freedom to reduce the cost and complexity of implementing defect tolerance. One strategy is to enable asymmetric repair capability within a 3-D memory stack by exploiting the degree of freedom that the order of the die in the stack can be selected. This technique optimizes the number of fuses, and in some cases, the number of spares as well, required to implement defect tolerance. Another innovative technique is to exploit rotational symmetry of the dies to do implicit reconfiguration to implement defect tolerance. Results show that leakage power and performance overhead for defect tolerance can be significantly reduced by this technique. / text

Standard recovery solution on a failed task in Hadoop systems is to execute the task again. After retrying for a configured number of times, it is marked as failure. With significant amount of data, complicated Map and Reduce functions, recovering corrupted or unfinished data from a failed job can be more efficient than re-executing the same job. This paper is an extension of [1] by applying fusion-based technique [7][8] in Hadoop MapReduce tasks execution to enhance its fault tolerance. Multiple data sets are executed through Hadoop MapReduce with and without fusion in various pre-defined failure scenarios for comparison. As the complexity of the Map and Reduce function relative to the Recover function increases, it becomes more efficient to utilize fusion and users can tolerate faults by incurring less than ten percent of extra execution time. / text

Tolerance to anesthetic drugs is mediated partially by homeostatic mechanisms that attempt to restore normal neural excitability. The BK-type Ca2+-activated K+ channel, encoded by the slo gene, plays an important role in this neural adaptation. In Drosophila, a single sedative dose of the organic solvent anesthetic benzyl alcohol induces dynamic spatiotemporal changes in histone H4 acetylation across the slo regulatory region and leads to slo induction and tolerance. Mutations ablating the expression of slo also block the acquisition of tolerance, whereas activating the expression of a slo transgene results in resistance to drug sedation. Moreover, artificially inducing histone acetylation with the histone deacetylase inhibitor causes similar acetylation changes, slo induction, and functional tolerance to the drug. Histone acetylation changes occur over two highly conserved non-coding DNA elements, 6b and 55b, of the slo control region. To investigate the function of these two elements, I generated individual knockout mutants by gene targeting. Both knockout alleles are backcrossed into the CS wild type background. The 6b element seems to repress slo induction after drug sedation, because the 6b knockout allele overreacts to the drug. Compared to the wild type, 6b knockout allele shows a much greater slo message induction after drug sedation, it also displays stronger enhancements in seizure susceptibility and following frequency. In addition, the 6b deletion causes a persistent tolerance for at least a month, while tolerance only lasts about 10 days in wild type flies. My investigation also indicates that the 55b element limits basal slo expression in muscle. Finally, to investigate if the particular histone acetylation spikes are required for drug-induced slo induction and tolerance, I tether the histone-modifying enzymes, HDAC or HAT, to the 6b and 55b DNA elements, respectively. I observe that the positioning of an HDAC on these two elements blocks drug-induced slo induction and the development of tolerance. Therefore, histone acetylation across slo control region is required for the activation of slo and the acquisition of tolerance. / text

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When designing a lens, cost and manufacturing concerns are extremely challenging, especially with radical optical designs. The tolerance process is the bridge between design and manufacturing. Three techniques which improve the interaction between lens design and engineers are successfully shown in this thesis along with implementation of these techniques. First, a method to accurately model optomechanical components within lens design is developed and implemented. Yield improvements are shown to increase by approximately 3% by modeling optomechanical components. Second, a method utilizing aberration theory is applied to discover potential tolerance sensitivity of an optical system through the design process. The use of aberration theory gives an engineer ways to compensate for errors. Third, a method using tolerance grade mapping is applied to error values of an optical system. This mapping creates a simplified comparison method between individual tolerances and lens designs.

We compared water deficit responses of 'Tifsport', 'Tifway 419', 'Tifgreen 328', and 'MidIron' bermudagrass (Cynodon dactylon x Cynodon transvaalensis), and 'SeaSpray', 'SeaDwarf', and 'Sea Isle 1' seashore paspalum (Paspalum vaginatum Swartz) under a linear gradient irrigation system in the desert Southwest. Target irrigation levels were 100, 80, 60, and 40% (2009) and 100, 80, 70, 60, and 40% (2010) of standard reference evapotranspiration (ETo). Actual water applied (including rainfall) was 100%, 83%, 66%, and 49% of ETo (2009) and 100%, 83%, 75%, 66%, and 49% (2010). Canopy temperatures increased, and quality and dry matter production declined with reduced irrigation. For optimum turfgrass quality, 75 to 83% ETo replacement was required; for acceptable quality turfgrass, 66 to 75% ETo replacement was needed for bermudagrass, and 75 to 80% ETo for seashore paspalum. Spring green-up was delayed by drought. Bermudagrasses, particularly 'MidIron', performed better than seashore paspalums under water stress conditions.

Šio darbo tema pasirinkta siekiant pažinti socialinę realybę Lietuvoje, užimti tam tikrą, savo, kaip tyrėjo, poziciją, t.y. praplėsti nuomonę apie gana komplikuotą reiškinį, įvairių kultūrų tarpusavio sąveiką, jų santykius, kylančius konfliktus ir sprendimo būdus, t.y. išsiaiškinti ar šiuolaikinėje visuomenėje egzistuoja tolerancija. / A tolerance is a universal moral principal with its terms used in such areas as social, cultural and religious. It helps to find out more about our attitude towards discrimination. The term named “tolerance” is very applicable for the acceptance and respect. Using tolerance as a term in our lives help us to show how we appreciate other people. Mostly, that means our acceptance and respect. The tolerance presumes comprehensible and respectful treatment towards other people. If we are talking about the situation in Lithuania, so the tolerance level is not high enough, because the majority does not tolerate other people unless they are their friends or relatives. On the other hand, the history of Lithuania speaks a lot about the whole situation which is in our country at this moment. Russian and polish people had been occupied Lithuania in past, that is why Lithuanian people do not want to respect or to tolerate them at all unless, as it was mentioned already, they would be their relatives or friends. The only one solution would be just to get some experience from the past, but do not take it with you at the present moment. Think of the past, but learn something from it, do not think of the bad things happened to you or to your relatives in the past, this is how we could be more tolerance to each other. This is how all Lithuanian people, does not matter are they Lithuanians or Russians or Polish or Belorussians, could achieve harmony of their relationship in our native country... [to full text]

Soil salinity is a serious environmental stress threatening productivity of major crops worldwide. Among the various biotic and abiotic strategies that exist, transgenic technologies provide a promising avenue to reduce yield losses in crops under saline environments. Recently, transgenic technology involving the TMT gene encoding thiol methyltransferase enzyme has been suggested as an effective solution for engineering a chloride detoxification capability into a high value crops to improve tolerance against chloride ion toxicity under saline environments. This proposed mechanism, however, results in the emission of methyl chloride (CH3Cl) from plants, which has deleterious effects on stratospheric ozone. This study was performed to examine the relationship between salt tolerance and chloride volatilizing capacity of transgenic plants containing TMT gene as well as to explore the possibility of generating transgenic rice crop containing TMT gene for salinity tolerance. To achieve these objectives, transgenic tobacco plants containing TMT gene were grown in comparison with wild type tobacco plants under three levels of sodium chloride (NaCl) salinity (0, 100 and 200 mM), three levels of soil water content (40%, 60% and 80% of the field capacity) and their tolerance to NaCl and water stress was studied. Plant growth parameters recorded included plant height, number of leaves, leaf area, stem dry weight, leaf dry weight, root dry weight, plant dry biomass and root/shoot ratio. Similarly, both types of plants were exposed to five levels of NaCl concentrations (0, 50, 100, 150 and 200 mM) and three levels of soil water content (40%, 60% and 80% of the field capacity), and the quantity of CH3Cl emitted was recorded. Significant decrease in plants growth parameters of both types of plants were recorded upon exposure to salinity and water stress. Under 100 mM NaCl, however, transgenic plants showed better tolerance to salinity by suffering less reduction in growth parameters compared to wild type plants. Under 200 mM NaCl, growth of both types of plants was completely inhibited. The interactive effects of salinity and water stress were more pronounced in wild type plants than in transgenic plants. Results also showed that all engineered plants acquired an ability to efficiently transform chloride ion to CH3Cl, and the rate of such transformation was higher under greater NaCl and soil water content compared to lower NaCl concentrations and soil water content. In order to explore the possibility of generating a transgenic food crop using TMT gene, a hypothetical transgenic rice crop was grown over 27 million hectares of the saline coastal areas of south and southeast Asia and the possible emission of CH3Cl from such ecosystem was inferred based on the CH3Cl emission data obtained from transgenic tobacco plants. The estimates showed that the possible CH3Cl emission from such ecosystem would be 219.21 Gg which is equivalent to 5.36 % of the global atmospheric emissions of CH3Cl.