L’objectif en arrière-plan est de montrer que plusieurs modèles de marches aléatoires en milieux aléatoires (MAMA) sont reliés à un modèle-jouet appelé le modèle de piège de Bouchaud. Le domaine des MAMA est très vaste, mais nous nous intéressons particulièrement à une classe de modèle où la marche est réversible et directionnellement transiente. En particulier, nous verrons pourquoi on pense que ces modèles se ressemblent et quel genre de similarités on s’attend à obtenir, une fois qu’on aura présenté le modèle de Bouchaud. Nous verrons aussi quelques techniques de base utilisés de ce domaine, telles que les temps de régénérations. Comme contribution, nous allons démontrer un théorème central limite pour la marche aléatoire β-biaisée sur un arbre de Galton-Watson. / This Master thesis is part of a larger project of linking the behaviours of a certain type of random walks in random environments (RWRE) with those of a toy model called the Bouchaud’s trap model. The domain of RWRE is very wide but our interest will be on a particular kind of models which are reversible and directionally transient. More specifically, we will see why those models have similar behaviours and what kind of results we could expect once we have reviewed the Bouchaud’s trap model. We will also present some basic technic used in this field, such as regeneration times. As a contribution, we will demonstrate a central limit theorem for the β-biased random walk on a Galton-Watson tree.

Bakgrund: Palliativ sedering avser en avsiktlig sänkning av medvetandegraden hos en patient som befinner sig i livets slutskede och har outhärdliga symtom. Behandlingen ges av ett multiprofessionellt team där sjuksköterskornas uppgift är att iordningställa och administrera ordinerade läkemedel samt utvärdera effekt och upplevelse av behandlingen. Förutom de praktiska kraven som ställs på sjuksköterskorna medför palliativ sedering även krav på förmåga till reflektion och kritiskt såväl som etiskt tänkande. Syfte: Syftet med denna litteraturöversikt var att undersöka sjuksköterskors erfarenheter av palliativ sedering. Metod: En litteraturöversikt genomfördes och tio vetenskapliga artiklar valdes ut till analys efter litteratursökningar i databaserna CINAHL Complete och PubMed. Resultat: Tre teman med underteman identifierades. God palliativ vård inkluderade att ge palliativ sedering för att erbjuda patient, närstående och personal ett fridfullt avslut och för att uppfylla patientens önskningar. Palliativ sedering och eutanasi kunde vara svåra att skilja från varandra och sjuksköterskorna hade en känsla av att palliativ sedering påskyndande patientens död. Att arbeta i team var en viktig faktor för hur sjuksköterskor upplevde arbetet med palliativ sedering. Det underlättade om beslut om sedering togs gemensamt och olika former av stöd från teamet var betydelsefullt för sjuksköterskor under arbetet med palliativ sedering. Diskussion: Resultaten diskuterades utifrån Jean Watsons omvårdnadsteori om mänsklig omsorg och tre av hennes caritasprocesser Ett kärleksfullt och omsorgsfullt sinnelag, Utrymme för känslor och Hjälpsamma och tillitsfulla omsorgsrelationer. / Background: Palliative sedation refers to an intentional lowering of consciousness of a patient in the end of life who is suffering from unbearable symptoms. The care is performed by a multi-professional team where the nurses’ duties are to prepare, administer and evaluate prescribed pharmaceuticals. In addition to the practical skills required by the nurses, this treatment also requires ability to reflect as well as critical and ethical thinking. Aim: The aim of this literature review was to explore nurses’ experiences of palliative sedation. Method: A literature review was conducted and ten scientific articles were chosen for analysis. Literature searches were made in the databases CINAHL Complete and PubMed. Results: Three themes with subthemes were identified. Good palliative care included giving palliative sedation to offer patients, families and the staff a peaceful ending and to meet the patient’s wishes. Palliative sedation and euthanasia could be difficult to separate and there was a sense that palliative sedation hastened the patient’s death. Teamwork was an important factor for how nurses experienced working with palliative sedation. It was easier if the decision to sedate was taken jointly and support within the team was meaningful to nurses during their work with palliative sedation. Discussion: The results were discussed in relation to Jean Watson’s Theory of Human Caring and the three caritas processes The practice of loving kindness and equanimity, Promotion and acceptance of the expression of positive and negative feelings and Developing and sustaining a helping-trusting caring relationship.

Les limites d’échelle de grands arbres aléatoires jouent un rôle central dans cette thèse.Nous nous intéressons plus spécifiquement au comportement asymptotique de plusieurs fonctions codant des arbres de Galton-Watson conditionnés. Nous envisageons plusieurs types de conditionnements faisant intervenir différentes quantités telles que le nombre total de sommets ou le nombre total de feuilles, avec des lois de reproductions différentes.Lorsque la loi de reproduction est critique et appartient au domaine d’attraction d’uneloi stable, un phénomène d’universalité se produit : ces arbres ressemblent à un même arbre aléatoire continu, l’arbre de Lévy stable. En revanche, lorsque la criticalité est brisée, la communauté de physique théorique a remarqué que des phénomènes de condensation peuvent survenir, ce qui signifie qu’avec grande probabilité, un sommet de l’arbre a un degré macroscopique comparable à la taille totale de l’arbre. Une partie de cette thèse consiste à mieux comprendre ce phénomène de condensation. Finalement, nous étudions des configurations non croisées aléatoires, obtenues à partir d’un polygône régulier en traçant des diagonales qui ne s’intersectent pas intérieurement, et remarquons qu’elles sont étroitement reliées à des arbres de Galton-Watson conditionnés à avoir un nombre de feuilles fixé. En particulier, ce lien jette un nouveau pont entre les dissections uniformes et les arbres de Galton-Watson, ce qui permet d’obtenir d’intéressantes conséquences de nature combinatoire. / Scaling limits of large random trees play an important role in this thesis. We are more precisely interested in the asymptotic behavior of several functions coding conditioned Galton-Watson trees. We consider several types of conditioning, involving different quantities such as the total number of vertices or leaves, as well as several types of offspring distributions. When the offspring distribution is critical and belongs to the domainof attraction of a stable law, a universality phenomenon occurs: these trees look like the samecontinuous random tree, the so-called stable Lévy tree. However, when the offspring distributionis not critical, the theoretical physics community has noticed that condensation phenomenamay occur, meaning that with high probability there exists a unique vertex with macroscopicdegree comparable to the total size of the tree. The goal of one of our contributions is to graspa better understanding of this phenomenon. Last but not least, we study random non-crossingconfigurations consisting of diagonals of regular polygons, and notice that they are intimatelyrelated to Galton-Watson trees conditioned on having a fixed number of leaves. In particular,this link sheds new light on uniform dissections and allows us to obtain some interesting resultsof a combinatorial flavor.

Le système immunitaire adaptatif est capable de produire une réponse spécifique contre presque tous le pathogènes qui agressent notre organisme. Ceci est dû aux anticorps qui sont des protéines secrétées par les cellules B. Les molécules qui provoquent cette réaction sont appelées antigènes : pendant une réponse immunitaire, les cellules B sont soumises à un processus d’apprentissage afin d’améliorer leur capacité à reconnaitre un antigène donne. Ce processus est appelé maturation d’affinité des anticorps. Nous établissons un cadre mathématique très flexible dans lequel nous définissons et étudions des modelés évolutionnaires simplifies inspirés par la maturation d’affinité des anticorps. Nous identifions les éléments constitutifs fondamentaux de ce mécanisme d’évolution extrêmement rapide et efficace : mutation, division et sélection. En commençant par une analyse rigoureuse du mécanisme de mutation dans le Chapitre 2, nous procédons à l’enrichissement progressif du modelé en ajoutant et analysant le processus de division dans le Chapitre 3 ,puis des pressions sélectives dépendantes de l’affinité dans le Chapitre 4. Notre objectif n’est pas de construire un modèle mathématique très détaillé et exhaustif de la maturation d’affinité des anticorps, mais plutôt d’enquêter sur les interactions entre mutation, division et sélection dans un contexte théorique simplifie. On cherche à comprendre comment les différents paramètres biologiques influencent la fonctionnalité du système, ainsi qu’à estimer les temps caractéristiques de l’exploration de l’espace d’états des traits des cellules B. Au-delà des motivations biologiques de la modélisation de la maturation d’affinité des anticorps, l’analyse de ce processus d’apprentissage nous a amenée à concevoir un modèle mathématique qui peut également s’appliquer à d’autres systèmes d’évolution, mais aussi à l’étude de la propagation de rumeurs ou de virus. Notre travail théorique s’accompagne de nombreuses simulations numériques qui viennent soit l’illustrer soit montrer que certains résultats demeurent extensibles a des situations plus compliquées. / The adaptive immune system is able to produce a specific response against almost any pathogen that could penetrate our organism and inflict diseases. This task is assured by the production of antigen-specific antibodies secreted by B-cells. The agents which causes this reaction are called antigens: during an immune response B-cells are submitted to a learning process in order to improve their ability to recognize the immunizing antigen. This process is called antibody affinity maturation. We set a highly flexible mathematical environment in which we define and study simplified mathematical evolutionary models inspired by antibody affinity maturation. We identify the fundamental building blocks of this extremely efficient and rapid evolutionary mechanism: mutation, division and selection. Starting by a rigorous analysis of the mutational mechanism in Chapter 2, we proceed by successively enriching the model by adding and analyzing the division process in Chapter 3 and affinity-dependent selection pressures in Chapter 4. Our aim is not to build a very detailed and comprehensive mathematical model of antibody affinity maturation, but rather to investigate interactions between mutation, division and selection in a simplified theoretical context. We want to understand how the different biological parameters affect the system’s functionality, as well as estimate the typical time-scales of the exploration of the state-space of B-cell traits. Beyond the biological motivations of antibody affinity maturation modeling, the analysis of this learning process leads us to build a mathematical model which could be relevant to model other evolutionary systems, but also gossip or virus propagation. Our method is based on the complementarity between probabilistic tools and numerical simulations.

Analisa os objetivos e propostas de organização da informação desenvolvidos pelo Movimento Bibliográfico e indica sua influência na Ciência da Informação. Esta pesquisa de natureza exploratória, realizada através de levantamento, revisão e análise bibliográficos, investiga o pensamento de Paul Otlet, Wilhelm Ostwald, H. G. Wells, John Cotton Dana e Watson Davis, expoentes do Movimento Bibliográfico, no contexto da modernidade. O Movimento Bibliográfico caracterizava-se por sua pluralidade e buscava responder às alterações no mundo informacional decorrentes da modernidade. O movimento atribuía à informação a potencialidade de transformação dos indivíduos e, portanto, transformou o foco dos serviços de informação da preservação para o acesso, procurando organizar acervos em função de seus conteúdos. O desenvolvimento tecnológico contemporâneo ao movimento fez com que seus expoentes enfatizassem a aplicação de novas tecnologias ao processo de disseminação da informação, pois entendiam que este seria facilitado e agilizado. A Ciência da Informação herdou seu papel social parcialmente do Movimento Bibliográfico, objetivando a organização da informação para seu acesso, e compartilha com o movimento a perspectiva de emprego de alta tecnologia na disseminação da informação. O espírito do tempo no qual se originou o Movimento Bibliográfico levou ao aparecimento de um ideário comum que permitiu a elaboração de propostas similares, entretanto, não se descarta a influência mútua entre os indivíduos analisados na pesquisa. Apesar de sua especificidade histórica, o Movimento Bibliográfico compartilha com a Ciência da Informação o ideário informacional moderno e a relação deste com a cultura. Conclui-se que a cultura da informação contemporânea e aquela do movimento pesquisado apresentam diferenças, porém são culturas que se entrelaçam; muitos de seus problemas sendo semelhantes e necessitando soluções similares. / Analyses the objectives and proposals of information organisation developed by the Bibliographic Movement, and indicates its influence in Information Science. This exploratory research, accomplished through bibliographic survey, literature review, and analysis, investigates in the context of modernity the ideas of Bibliographic Movement exponents Paul Otlet, Wilhelm Ostwald, H. G. Wells, John Cotton Dana, and Watson Davis. The Bibliographic Movement was characterized by its plurality, and aimed to respond to modernity\'s effects in the information world. The movement attributed to information the potentiality of individual transformation. Therefore, it changed the focus of information services from preservation to access, and pursued the organisation of collections according to its contents. The development of technology made the Bibliographic Movement exponents emphasise the application of new technologies to the process of information dissemination in order to facilitate and accelerate it. Information Science inherited its social role partially from the Bibliographic Movement, and aims at organising information so that it can be accessed. Information Science also shares with the movement the perspective of employing high technology to disseminate information. The Zeitgeist that gave rise to the Bibliographic Movement led to a common set of ideas and allowed the elaboration of similar proposals for the organisation of information. However, it is not discarded the probability of mutual influence between the individuals analysed. Despite its historical specificity the Bibliographic Movement shares with Information Science modern ideas and its relation to culture. It is concluded that the current information culture and the information culture of the Bibliographic Movement have differences, notwithstanding, they are entwined cultures and many of their problems are similar and need similar solutions

O mercado cinematográfico pode ser caracterizado como uma indústria de entretenimento com a produção de bens de informação que são também bens de experiência, cuja qualidade só é conhecida após o consumo. Deste modo, a revisão crítica se torna importante para induzir seu consumo, fornecendo previamente algum grau de informação sobre a qualidade do bem. Segue-se o trabalho de Reinstein e Snyder (2005) para determinar se as revisões críticas conduzidas por consumidores e por críticos profissionais online afetam o tempo de exibição de filmes no mercado americano de cinema, medido em quantidades de semanas, conforme modelos de duração/sobrevivência na literatura. Para esta finalidade foi gerado, a partir de sites de cinemas americanos (Box Office Mojo e Rotten Tomatoes), um banco de dados extremamente rico com informações semanais de todos os filmes disponíveis no cinema americano de 2004 a 2015. Especificamente, investigou-se os efeitos das revisões críticas de críticos profissionais de primeira linha (Tops) e de consumidores, conforme a média das notas atribuídas na semana de lançamento de cada filme. No que se refere à avaliação dos consumidores foi aplicada a computação afetiva, que reconhece o sentimento e a emoção em suas resenhas online para captar o efeito boca a boca potencializado pelas mídias sociais e fornecendo, portanto, uma análise mais profunda do boca a boca online. O estudo controla por possíveis problemas de endogeneidade decorrente de simultaneidade, usando as críticas somente antes e durante a semana de lançamento dos filmes. Os resultados sugerem que os críticos profissionais exercem grande influência no tempo de duração dos filmes em cartaz, bem como a positividade dos consumidores em relação ao filme. No entanto, o efeito dos críticos profissionais é em média 3 vezes maior do que dos consumidores. Adicionalmente, pode-se observar que algumas emoções afetam a expectativa de vida dos filmes a depender do gênero do mesmo / The movie market may be considered as entertainment industry, which produces experience goods that is also information goods, whose quality is only known only after consumption. Thus, critical reviews becomes important to induce consumption, since it provides some level of information about product quality. We follow Reinstein and Snyder (2005) works in order to determine if experts and consumers online critical reviews affect the survival time of movies at the American movie market, measured by number of weeks, according to survival analysis models in the literature. For this purpose, an extremely rich database with weekly information on all the films available in American cinema from 2004 to 2015 was generated from American movie sites (Box Office Mojo and Rotten Tomatoes). Specifically, we investigate the effects of critical reviews from top professionals and from consumers, according to the average ratings assigned in each movie\'s release week. As far as consumer assessment was concerned, affective computing was applied, which recognizes the sentiment (sentiment analysis) and emotion (emotion mining) in their online reviews to capture the word-of-mouth effect boosted by social media. The study controls for possible problems of endogeneity due to simultaneity, using the criticisms before and during the week of release of the films. The results suggest that the professional critics exert a great influence on the duration of the films in exhibition, as well as the positivity of the consumers in relation to the film. Thus, the effect of professionals are 5 times greater, generally, than the effect of the consumer critics. Additionally, it can be observed that some emotions affect movie life expectancy depending on the its genre

No description available.

Analisa os objetivos e propostas de organização da informação desenvolvidos pelo Movimento Bibliográfico e indica sua influência na Ciência da Informação. Esta pesquisa de natureza exploratória, realizada através de levantamento, revisão e análise bibliográficos, investiga o pensamento de Paul Otlet, Wilhelm Ostwald, H. G. Wells, John Cotton Dana e Watson Davis, expoentes do Movimento Bibliográfico, no contexto da modernidade. O Movimento Bibliográfico caracterizava-se por sua pluralidade e buscava responder às alterações no mundo informacional decorrentes da modernidade. O movimento atribuía à informação a potencialidade de transformação dos indivíduos e, portanto, transformou o foco dos serviços de informação da preservação para o acesso, procurando organizar acervos em função de seus conteúdos. O desenvolvimento tecnológico contemporâneo ao movimento fez com que seus expoentes enfatizassem a aplicação de novas tecnologias ao processo de disseminação da informação, pois entendiam que este seria facilitado e agilizado. A Ciência da Informação herdou seu papel social parcialmente do Movimento Bibliográfico, objetivando a organização da informação para seu acesso, e compartilha com o movimento a perspectiva de emprego de alta tecnologia na disseminação da informação. O espírito do tempo no qual se originou o Movimento Bibliográfico levou ao aparecimento de um ideário comum que permitiu a elaboração de propostas similares, entretanto, não se descarta a influência mútua entre os indivíduos analisados na pesquisa. Apesar de sua especificidade histórica, o Movimento Bibliográfico compartilha com a Ciência da Informação o ideário informacional moderno e a relação deste com a cultura. Conclui-se que a cultura da informação contemporânea e aquela do movimento pesquisado apresentam diferenças, porém são culturas que se entrelaçam; muitos de seus problemas sendo semelhantes e necessitando soluções similares. / Analyses the objectives and proposals of information organisation developed by the Bibliographic Movement, and indicates its influence in Information Science. This exploratory research, accomplished through bibliographic survey, literature review, and analysis, investigates in the context of modernity the ideas of Bibliographic Movement exponents Paul Otlet, Wilhelm Ostwald, H. G. Wells, John Cotton Dana, and Watson Davis. The Bibliographic Movement was characterized by its plurality, and aimed to respond to modernity\'s effects in the information world. The movement attributed to information the potentiality of individual transformation. Therefore, it changed the focus of information services from preservation to access, and pursued the organisation of collections according to its contents. The development of technology made the Bibliographic Movement exponents emphasise the application of new technologies to the process of information dissemination in order to facilitate and accelerate it. Information Science inherited its social role partially from the Bibliographic Movement, and aims at organising information so that it can be accessed. Information Science also shares with the movement the perspective of employing high technology to disseminate information. The Zeitgeist that gave rise to the Bibliographic Movement led to a common set of ideas and allowed the elaboration of similar proposals for the organisation of information. However, it is not discarded the probability of mutual influence between the individuals analysed. Despite its historical specificity the Bibliographic Movement shares with Information Science modern ideas and its relation to culture. It is concluded that the current information culture and the information culture of the Bibliographic Movement have differences, notwithstanding, they are entwined cultures and many of their problems are similar and need similar solutions

O mercado cinematográfico pode ser caracterizado como uma indústria de entretenimento com a produção de bens de informação que são também bens de experiência, cuja qualidade só é conhecida após o consumo. Deste modo, a revisão crítica se torna importante para induzir seu consumo, fornecendo previamente algum grau de informação sobre a qualidade do bem. Segue-se o trabalho de Reinstein e Snyder (2005) para determinar se as revisões críticas conduzidas por consumidores e por críticos profissionais online afetam o tempo de exibição de filmes no mercado americano de cinema, medido em quantidades de semanas, conforme modelos de duração/sobrevivência na literatura. Para esta finalidade foi gerado, a partir de sites de cinemas americanos (Box Office Mojo e Rotten Tomatoes), um banco de dados extremamente rico com informações semanais de todos os filmes disponíveis no cinema americano de 2004 a 2015. Especificamente, investigou-se os efeitos das revisões críticas de críticos profissionais de primeira linha (Tops) e de consumidores, conforme a média das notas atribuídas na semana de lançamento de cada filme. No que se refere à avaliação dos consumidores foi aplicada a computação afetiva, que reconhece o sentimento e a emoção em suas resenhas online para captar o efeito boca a boca potencializado pelas mídias sociais e fornecendo, portanto, uma análise mais profunda do boca a boca online. O estudo controla por possíveis problemas de endogeneidade decorrente de simultaneidade, usando as críticas somente antes e durante a semana de lançamento dos filmes. Os resultados sugerem que os críticos profissionais exercem grande influência no tempo de duração dos filmes em cartaz, bem como a positividade dos consumidores em relação ao filme. No entanto, o efeito dos críticos profissionais é em média 3 vezes maior do que dos consumidores. Adicionalmente, pode-se observar que algumas emoções afetam a expectativa de vida dos filmes a depender do gênero do mesmo / The movie market may be considered as entertainment industry, which produces experience goods that is also information goods, whose quality is only known only after consumption. Thus, critical reviews becomes important to induce consumption, since it provides some level of information about product quality. We follow Reinstein and Snyder (2005) works in order to determine if experts and consumers online critical reviews affect the survival time of movies at the American movie market, measured by number of weeks, according to survival analysis models in the literature. For this purpose, an extremely rich database with weekly information on all the films available in American cinema from 2004 to 2015 was generated from American movie sites (Box Office Mojo and Rotten Tomatoes). Specifically, we investigate the effects of critical reviews from top professionals and from consumers, according to the average ratings assigned in each movie\'s release week. As far as consumer assessment was concerned, affective computing was applied, which recognizes the sentiment (sentiment analysis) and emotion (emotion mining) in their online reviews to capture the word-of-mouth effect boosted by social media. The study controls for possible problems of endogeneity due to simultaneity, using the criticisms before and during the week of release of the films. The results suggest that the professional critics exert a great influence on the duration of the films in exhibition, as well as the positivity of the consumers in relation to the film. Thus, the effect of professionals are 5 times greater, generally, than the effect of the consumer critics. Additionally, it can be observed that some emotions affect movie life expectancy depending on the its genre

Dans cette thèse nous nous sommes intéressés de trois types de problèmes : 1 -Existence et unicité d’une fonction harmonique strictement positive associée à une marche aléatoire inhomogène confinée dans un orthant. 2 -Etude de la convergence en loi des arbres de Galton Watson critiques conditionnés à avoir un nombre assez grand de noeuds protégés. 3 -Etude de la convergence en loi des arbres de Galton Watson conditionnés à avoir une génération anormalement grande. / In this thesis we are interested in three types of problems: 1-Existence and uniqueness of a positive harmonic function associated with an inhomogeneous random walk confined in an orthant. 2-Study of convergence in distribution of critical Galton Watson trees conditioned to have a large enoughnumber of protected nodes. 3-Study of the convergence in distribution of Galton Watson trees conditioned to have a large generation.