FundaÃÃo Cearense de Apoio ao Desenvolvimento Cientifico e TecnolÃgico / A Lippia alba à uma planta medicinal muito utilizada pela populaÃÃo brasileira para o tratamento de diversas doenÃas. A composiÃÃo quÃmica de seu Ãleo essencial apresenta variaÃÃo quantitativa e qualitativa, classificando em quimiotipos. No CearÃ, o quimiotipo II à reconhecido pelo Ãleo essencial de L. alba (OELaII) conter elevados teores de limoneno e citral. A cicatrizaÃÃo de feridas envolve eventos celulares e moleculares que interagem para que ocorra a reconstituiÃÃo do tecido. A contaminaÃÃo bacteriana, principalmente por S. aureus, à um dos principais fatores que afeta a cicatrizaÃÃo. O objetivo desse estudo foi investigar o mecanismo de aÃÃo do OELaII sobre S. aureus e sua atividade cicatrizante. O mecanismo de aÃÃo foi avaliado atravÃs de alteraÃÃes da membrana, na morfologia bacteriana e na inibiÃÃo de fatores de virulÃncia. A aÃÃo cicatrizante foi determinada in vivo em modelo experimental de feridas cutÃneas atravÃs da Ãrea da ferida, da contraÃÃo, da anÃlise clÃnica, histopatolÃgica e microbiolÃgica. O mecanismo de aÃÃo do OELaII sobre S. aureus ocorreu por aÃÃo direta no envoltÃrio celular comprovada pela alteraÃÃo irreversÃvel na permeabilidade da membrana citoplasmÃtica, pois os resultados mostraram aumento da captaÃÃo de cristal violeta, liberaÃÃo de Ãcidos nucleicos e efluxo de potÃssio, bem como danos na parede bacteriana visualizado por Microscopia de ForÃa AtÃmica. Junto a isso, a inibiÃÃo dos fatores de virulÃncia evidenciada nesse estudo, pode estar associada a alteraÃÃes na expressÃo gÃnica, bem como favorecer a hipÃtese que o OELaII modifique o padrÃo de secreÃÃo enzimÃtica, por alteraÃÃo da membrana celular. Nos resultados da cicatrizaÃÃo, os grupos tratados com OELaII e formulaÃÃes a base de OELaII, aceleraram o processo de cicatrizaÃÃo, promovendo um significativo aumento na porcentagem de contraÃÃo das feridas e reepitelizaÃÃo. Os resultados nesses grupos mostraram que ao longo do tratamento, ocorreu uma diminuiÃÃo significativa da populaÃÃo microbiana, fornecendo condiÃÃes locais favorÃveis por meio da terapia tÃpica com vistas aos melhores resultados e o menor tempo possÃvel do processo de cicatrizaÃÃo. Por conseguinte, os dados encontrados neste estudo mostraram que o OELaII à um agente cicatrizante de feridas cutÃneas, com elevada atividade antimicrobiana e que essas atividades biolÃgicas reforÃam o grande potencial do OELaII como candidato ao desenvolvimento de um fÃrmaco de uso tÃpico, eficaz no tratamento de feridas cutÃneas, em diversas situaÃÃes clÃnicas.

Conselho Nacional de Desenvolvimento CientÃfico e TecnolÃgico

Mohandas Karamchand Gandhi contributed both to the Indian civil rights movement in South Africa and India's hind-swaraj (Indian home-rule) movement as a charismatic leader and spiritual warrior. In both cases Gandhi employed satyagraha, often translated as ‘soul force', as his community organizing and mobilizing strategy against the British Empire. Used to great effect this non-violent method of protest accomplished tangible victories in both movements. However, the success enjoyed by Gandhi's social movements varied wildly. In South Africa, Gandhi mobilized Indians against local legislative measures designed to strip them of their voting rights. Throughout this period Gandhi underwent a significant ideological shift, from Aryan supremacist, to humanitarian spiritualist. His appeal spread throughout the Indian world, and soon even English were contributing to his movement. Yet, victories never amounted to the democratization of the colony, let alone equal rights for Indian laborers. In India1 wee see Gandhi’s mobilization of Indians in the name of hind-swaraj lead to the withdrawal of British power from the nation. However, I speculate that this success had as much to do with Indian nationalist Subhas Chandra Bose, as it did Mohandas Gandhi. Bose and Gandhi each led hind-swaraj movements that conflicted deeply on an ideological and strategic basis. While Gandhi focused on the power of nonviolent civil disobedience within a state, Bose focused on diplomacy with Britain's enemies and the use of international pressures. The cumulative pressure of both movements during the British Empire's weakest moment. WWII, resulted in hind-swaraj.

La reflexión crítica y académica sobre las relaciones entre derecho y violencia es esencialmente compleja. Una primera aproximación elemental podría ser partir de la teoría de las fuentes del Derecho, ya sea en términos de fuentes materiales (v.g. la violencia como fenómeno interdisciplinario1), como de fuentes formales (v.g. doctrinarios: los derechos humanos y la violencia; normativos y jurisprudenciales: la sanción penal por las conductas violentas). Desde nuestra perspectiva jus disciplinaria4 esta aproximación nos conduce a consideraciones temáticas como la paz por oposición a la violencia y en ese sentido el imperativo de abordar concepciones relativas al pacifismo y la no violencia, que servirán de sustento para postular expresiones formalizadas (juridificadas) acerca de la violencia y el ambiente5. Al respecto, la cultura de la no violencia se alimenta y encuentra profundamente arraigada en los movimientos ecologistas (ecopacifismo), teniendo entre su mentores a Gandhi, Schumacher, al propio Einstein —añadiríamos al «viejo» Russell— a Vandana Shiva en tiempos recientes, por mencionar algunos.

INTRODUCTION: Idiopathic granulomatous mastitis (IGM) is becoming more commonly recognized and reported more often. Currently, many recommend corticosteroids in its management. PRESENTATION OF CASE: A 34-year-old G3P2 Hispanic female, 28 weeks pregnant, presented with a 19 cm right breast mass. She had a known prolactinoma treated with bromocriptine which was discontinued during her pregnancy. Ultrasound guided core biopsy procedure revealed granulomatous mastitis. The patient was told that the mass would resolve with observation. The patient seen at another institution by an infectious disease specialist who started treatment with amphotericin for presumptive disseminated coccidioidomycosis. Repeated titers were negative for coccidioides antibody. Repeat cultures were negative as well. Due to the persistence of the infectious disease specialist, tissue cultures were performed on fresh tissue specimens, which did not grow bacterial, fungal, nor acid fast organisms. The amphotericin regimen resulted in no improvement of her breast mass after 10 weeks. Within two weeks of stopping the antifungal therapy, however, the mass diminished to 6 cm. The patient delivered at 39 weeks. Bromocriptine was restarted, and within 4 weeks, the lesion was no longer palpable. She had not shown signs of recurrence for 32 months. DISCUSSION: Treatment recommendations for IGM vary widely but antibiotics and antifungal medications are not recommended. Corticosteroid treatment is most commonly recommended, however, outcomes may not be different from management with observation. Prolactin may be involved in the pathophysiology of the process. CONCLUSION: IGM is becoming recognized more frequently. Observation and patience with natural history can be an effective management. (C) 2015 The Authors. Published by Elsevier Ltd. on behalf of Surgical Associates Ltd.

The 2019-2020 Academic Affairs Committee was charged with identifying promising practices in academic-practice partnerships and professional pharmacy organization initiatives that are accelerating the transformation of a workforce prepared to assume responsibility for society’s medication use needs in 2030 and determining the role AACP can plan in supporting these partnerships and initiatives. The committee identified a set of ideal principles, characteristics, and design elements of a high-quality, large-scale workforce development program. The committee also categorized current mechanisms for professional workforce development, in addition to identifying their strengths and weaknesses, with the realization that novel approaches are needed to accomplish the goal of large-scale workforce trans-formation. This report also highlights two existing initiatives aligned with accelerating the transformation of the workforce (ie, the Community Pharmacy Enhanced Services Network (CPESN) ACT (Academia-CPESN Transformation) Pharmacy Collaborative and the American Pharmacists Association ADVANCE platform) and is proposing a policy statement affirming AACP’s support. Further-more, the committee is proposing another policy statement supporting colleges and schools of pharmacy taking an active role in implementing innovative and novel approaches for the development of the current workforce. In order to truly understand the many factors influencing large-scale workforce transformation, the committee is also proposing a stakeholder conference with a wide range of participants and a targeted set of questions focused on current and future needs.

Localism places a special value on the local, and is increasingly prominent as a political doctrine. The literature suggests localism operates in three ways: bottom-up, top down and mutualistic. To assess its impact, localism needs to be seen within the broader context of multi-level governance. Here localism is examined in relation to three major themes: place, public value (PV), and institutional design. Regarding place, a key distinction is drawn between old and new localism. Old localism is about established local government, while new localism highlights the increasing room for manoeuvre that localities have in contemporary politics. This enables them to influence wider power structures, for example through trans-local organizing. With regard to public value, localist thinking makes a key contribution to core PV domains such as sustainability, wellbeing and democracy, as well as to others like territorial cohesion and intergovernmental mutuality. As for institutional design, the study is particularly concerned with ‘sub-continental’ political systems. A set of principles for the overall design of such systems is proposed, together with a framework of desirable policy outcomes at the local level. This can be used to evaluate how effective political systems are at creating public value in local settings. The thesis presents a comparative study of localism in two significant, sub-continental clusters: India/Kerala/Kollam and the EU/UK/England/Cornwall. Both can be seen as contrasting ‘exemplars’ of localism in action. In India, localism was a major factor in the nationwide local self-government reforms of 1993 and their subsequent enactment in the state of Kerala. In the EU, localism has been pursued through an economic federalism based on regions and sub-regions. This is at odds with the top-down tradition in British politics. The tension between the two approaches is being played out currently in the peripheral sub-region of Cornwall/Isles of Scilly. Cornwall’s dilemma has been sharpened by Britain’s recent decision to leave the EU. The thesis considers the wider implications of the case studies, and presents some proposals for policymakers and legislators to consider, together with suggestions for further research.

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This study aims at exploring the connections between nonviolence and sustainability in two cases. The relationship between nonviolence and sustainability is identified and discussed in light of the theories on nonviolence of Johan Galtung and theories of the ethical framework of ecocentrism. The theories are positioned in contrast to the two cases Swedish Muslims for Peace and Justice and The Sámi Parliament that are explored with connections to nonviolence and sustainability. The notion of peace and nonviolence and sustainable development is a relatively unexplored territory. So, through the first analysis of the two cases, I found three concepts of knowledge, cooperation and environment that appeared relevant. Therefore, I did my analysis with focus on these three concepts as helpful tools for the analysis and further discussion. These were used throughout the work in the study, in the light of the theories and vice versa, the material was then accessible. Then I could read between the lines and make the connections between nonviolence and sustainability, more explicit. The first conclusion made from this study is that nonviolence and sustainability are two realms that can and should be understood in terms of each other. Nonviolence and sustainability are both highlighted by understanding them in relationship to each other. There is a need to promote long-lasting peace. We also need to consider both people and nature to reduce our environmental footprints. We need to consider needs for all living beings, including nature. The study also concluded with a need for knowledge and cooperation to fight against structural and cultural violence. Furthermore, there is need to consider the earth and people, everything, and everyone in cooperation in the communal struggle´s, with focus on sustainable peace at every level of society.

In this article, we propose an estimation of the agriculture productivity using micro data forPeru. The method used builds on recent production function’s estimation techniques developed for panel data (e.g., Gandhi et al., 2013) but using cross-section data. Data constraints urge us to impose functional forms for the estimation. In particular, we choose the constant elasticity of substitution function, which is more flexible that other functions used by prior literature in Peru (such as the Cobb-Douglas). We find no evidence of the existence of increasing returns to scale in the Peruvian agriculture, and that the productivity is positively correlated with age, sex, andeducation, and negatively correlated with the farming unit’s acreage and market power. / En este artículo, proponemos la estimación de la productividad agrícola usando datos micro-económicos para el Perú. El método consiste en la estimación de una función de producción agraria, que permite recuperar la productividad como un residuo, y constituye una aplicación directa de desarrollos metodológicos recientes en la estimación de funciones de producción con datos de panel (e.g., Gandhi et al., 2013), pero aplicado en este artículo a datos de sección cru- zada. Debido a la menor información disponible para la estimación con respecto al caso de datos de panel, recurrimos a supuestos de formas funcionales. En particular, se escoge la función de elasticidad de sustitución constante, que permite una mayor flexibilidad que otras formas usadas previamente en la literatura empírica nacional, como la Cobb-Douglas. Encontramos que no hay sustento para la hipótesis de la existencia de retornos crecientes a escala; que la productividad está positivamente correlacionada con la edad, el sexo, y la educación; y negativamente relacionadacon el tamaño de la unidad agropecuaria y el poder de mercado.