The intent of diploma thesis is to propose the optimization of current logistic processes with utilization of modern information technology. The work will propose the tool for stock classiffication, further evaluates the options of the warehouse management system implementation, including on-line connection to SAP Business One ERP system, and proposes its utilization in optimization of company’s business processes. The result of this work is the recommended proposal of the best and as well as cost friendly solution for company ARKOV, Ltd.

This diploma thesis focuses on stock management and related issues in the automotive industry. The thesis is divided into a theoretical and a practical part. The theoretical part discusses general concepts of logistics and stock management. There are described patterns of production and its connection to the warehouse and logistics issues and more. The practical part focuses on a specific environment of companies operating in the automotive industry and describes its parts and logistics processes that are somehow related to the stock management. The practical part is also more elaborated on Aftermarket issues.

The diploma thesis focuses on problems related to the low turnover of stocks in IMI International, s.r.o. The thesis is divided into three parts – theoretical, analytical and design part. In the first part there is presented a basic theoretical knowledge of logistics for this work. The second part analyses the causes of high stock holdings in relation to low turnover. Based on the analyses there are finally proposed the solutions in order to reduce the value of held stocks by reducing the quantity which then leads to increased turnover.

Vga(A)LC and Msr(A) are clinically significant resistant proteins in staphylococci that confer resistance to translational inhibitors. They belong to ARE ABC-F protein subfamily, which is part of ABC transporters. Unlike typical ABC transporters, ABC-F proteins do not have transmembrane domains that are responsible for the transport of substances through the membrane. Therefore, they do not have characteristic transport function but regulatory or resistance function. Their mechanism of action on the ribosome has been described only recently, where these proteins displace the antibiotic from the ribosome. However, some aspects of their function are still unclear. For example, what is the function of the Vga(A) location on a membrane that has been detected in the membrane fraction but not in the ribosomal. In this work, using fluorescence microscopy, I observed subcellular localization of the Vga(A)LC-mEos2, Vga(A)LC-GFP and Msr(A)-eqFP650 resistant fusion proteins in live cells of S. aureus under different culture conditions . It has been shown that Vga(A)LC-GFP and Msr(A)-eqFP650 occur in a foci near the membrane. Depending on ATPase activity or the presence of an antibiotic, the localization of Msr(A)-eqFP650 in the cell changes from focal to diffuse, presumably on ribosomes, suggesting a...

El objetivo de la investigación está enfocado hacia el análisis de la correcta asignación del sistema de costeo ABC y la forma cómo influye en la toma de decisiones gerenciales en las empresas del sector servicios de publicidad. Para tal efecto, se situó el estudio en la población de las empresas publicitarias en Lima Metropolitana, de donde se tomó como muestra diez empresas, perteneciente al distrito de Miraflores, jurisdicción con mayor número de empresas de este sector. Con estos participantes se realizó un análisis sobre la viabilidad de la metodología de costeo ABC en el rubro publicitario, para luego, con la información brindada, fortalecer la aplicación de esta metodología a la empresa LUCYMARK S.A.C., en donde se realizará el estudio a profundidad. La investigación es de tipo no experimental, con un diseño transaccional correlacional. La primera variable de investigación es el sistema de costeo ABC, la cual se midió de acuerdo a los recursos, actividades y la cadena de valor. La segunda variable es la toma de decisiones gerenciales, basado en la medición de los indicadores, decisiones estratégicas, rentabilidad y ventaja competitiva. Por otro lado las técnicas de estudio utilizadas es la entrevista y luego la encuesta en ese orden; Por ultimo y en base al objetivo principal de la investigación se determinó que la correcta implementación del sistema de costeo ABC influye positivamente en la toma de decisiones gerenciales; esto de acuerdo a dos puntos clave que las empresas del sector deben desarrollar, que es la optimización de las actividades implementadas y el correcto desarrollo de la cadena de valor, este último por reflejar los procesos establecidos, las actividades primarias y de apoyo. / The objective of the research is focused on the analysis of the correct assignment of the ABC costing system and the way it influences management decision-making in companies in the advertising services sector. For this purpose, the study was placed on the population of advertising companies in Metropolitan Lima, from which ten companies were taken as a sample, belonging to the district of Miraflores, the jurisdiction with the largest number of companies in this sector. With these participants, an analysis was carried out on the viability feasibility of the ABC costing methodology in the advertising sector, and then, with the information provided, strengthen the application of this methodology to the company LUCYMARK S.A.C., where the in-depth study will be carried out. The research is non-experimental, with a transactional correlational design. The first research variable is the ABC costing system, which was measured according to resources, activities and the value chain; The second variable is managerial decision-making, based on the measurement of indicators, strategic decisions, profitability and competitive advantage. On the other hand, the study techniques used is the interview and then the survey in. Finally, and based on the main objective of the research, it was determined that the correct implementation of the ABC costing system positively influences management decision-making; This according to two key points that companies in the sector must develop, which is the optimization of the activities implemented and the correct development of the value chain, the latter reflecting the established processes, the primary activities and the support. / Tesis

This study examines how a reader in the Swedish subject can be used in the younger ages ofSwedish schools to meet the requirements of equal education in Sweden. The reader is a partof a teaching material called the ABC-klubben and is based on the same story but available inthree different levels of textbooks.The Study analyses how the different books differ between each other and how the techingmaterial can be used in its whole to increase the equal education. The study shows that in itswhole and if the material are used to create a shared reading experience between everyone inclass, it do contribute to equal education for students. The material has some difficulties andthe teacher needs to be aware he or she may need to compensate for some parts of thematerial.

Syfte – Syftet med studien är att identifiera enskilda parametrar på artiklar för att möjliggöra optimerad lagerstyrning i ett tillverkande företag med kundorderstyrd produktion. För att besvara syftet har tre frågeställningar formulerats. Vilka parametrar behöver tas hänsyn till för att optimera lagerstyrningen? Vilka parametrar kan identifieras i ett tillverkande företag med kundorderstyrd produktion? Hur kan identifierade artiklar användas inom lagerstyrning? Metod – Studien initierades med en förstudie för att belysa problematiken kring ämnet och dess kontext. Förstudien i kombination med en litteraturstudie bidrog till skapandet av syftet och formuleringen av studiens tre frågeställningar. Vidare är studien utformad enligt typen enfallsdesign där intervju användes som datainsamlingsmetod. Intervjun bidrog till kvalitativa primärdata där syftet var att åskådliggöra nyckelpersoners kunskap om det studerade ämnet. Resultat – Identifiering av viktiga parametrar för att optimera lönsamhet och lagerstyrning i ett företag är utmanande. Problematiken kring detta ligger i att identifiera rätt parametrar anpassade för ett företags produktionssätt samt belysa hur dessa ska implementeras. Denna studie behandlar parametrar, vilka är viktiga i kundorderstyrd miljö med hänsyn till olika funktioner i ett företag. Resultatet beskriver dessa parametrar samt påvisar hur parametrarna med fördel används i en ABC-klassificering för att styra lagret effektivt och lönsamt. Implikationer – Ämnesområdet kring lagerstyrning är väl utforskat inom existerande litteratur vilket bidrar till mindre utrymme att generera ny kunskap inom området. Trots detta bidrar denna studie till ny kunskap vilket stärker nuvarande forskning beträffande lagerstyrning i kundorderstyrd miljö. Detta då insamlad teori i kombination med empiri öppnar upp till nya fakta att ta i beaktande. Begränsningar – Studien omfattar enbart ett fallföretag vilket därtill påverkar studiens generaliserbarhet. Då studien fokuserar på lagerstyrning utifrån fem funktioner på fallföretaget kan inte studien generaliseras fullständigt mot andra likande företag. Vidare kan begränsningar återfinnas inom datainsamlingen där bara specifikt utvalda personer intervjuats vilket kan påverkat studiens resultat. / Purpose – The purpose of the study is to identify individual parameters on articles to enable optimized inventory management in a company with customer-controlled production. Three questions have been formulated to answer the purpose. Which parameters need to be considered to optimize inventory control? Which parameters can be identified in a company with customer order driven production? How can identified items be used in inventory management? Method – The study was initiated with a feasibility study to elucidate the problem of the subject and its context. The preliminary study in combination with a literature study contributed to the creation of the purpose and formulation of the study's three issues. Furthermore, the study is designed according to the type of one-case design where the interview was used as a data collection method. The interview contributed to qualitative primary data where the purpose was to illustrate key people's knowledge of the subject studied.  Findings – Identifying parameters that are important for optimizing profitability and inventory management in a company is challenging. The problem with this lies in identifying the right parameters adapted for a company's production method and elucidating how these should be implemented. This study addresses important parameters for customer order controlled environment regarding various functions of a company. The result describes these parameters and shows how the parameters are advantageously used in an ABC classification to control the layer effectively. Implications – The subject area of inventory management is well explored in existing literature, which contributes to less space to generate new knowledge in the area. Despite this, this study contributes to new knowledge, which strengthens current research on inventory management in customer-order-driven environments. This then-collected theory in combination with empirics opens up new facts to take into account. Limitations – The study comprises only one case company, which in addition affects the generalizability of the study. As the study focuses on inventory management based on five functions of the fall company, the study cannot be fully generalized to other similar companies. Furthermore, limitations can be found in the data collection where only specifically selected persons were interviewed which may have influenced the study's results.

Swedish retail industry is facing a challenging future in terms of creating positive customer experiences due to an increasingly digitized world. The market and shopping patterns have changed drastically, and customers expect a higher level of customer service while retail staff spend a lot of time receiving deliveries and handling goods. Successful work with Lean has long helped other industries to streamline their tasks. The question remains whether Lean can help create enabling conditions for the retailer to streamline product and inventory management and be able to allocate time to customer experiences instead. The purpose of this work is therefore to identify opportunities with methods such as ABC-analysis and 5S for improvement in goods and inventory management in retail in favour of increased customer satisfaction. The study was conducted as a case study at a retail store with an internal warehouse. To respond to the purpose, the delivery of goods was examined through observations as well as interviews were conducted with the store manager and two employees. The study was further supplemented by an interview with the logistics department at the company headquarters. The result shows that a frequency placement according to the picking frequency at the warehouse saves both time when delivering goods but also when picking out, this as the A-products are closest to the entrance. Improvement opportunities such as standardization of work tasks, visualization in store warehouses, focus on inventory turnover and structure in warehousing according to 5S were significant for the efficiency of the warehousing. The study is expected to contribute with understanding that methods developed for other industries can also be applied within the retail. Lean in retail is a recently explored area and our study gives an indication that warehouse efficiency is important for improved customer service. To make the study possible it is limited to streamlining storage of goods and handling of goods in the store warehouse.

(EN) Analogously to normal stem cells within the tissues, cancer stem cells (CSCs) have been proposed to be responsible for maintenance and growth of tumours. CSCs represent a small fraction of cells within the tumour, which is characterised by self-renewal capacity and ability to give rise to a tumour when grafted into immunocompromised mice. Cells with increased stemness properties are believed to be responsible for tumour resistance, metastases formation and relapse after tumour treatment. The first part of this work concentrates on resistance of the tumours, which is often associated with increased expression of ATP-binding cassete (ABC) transporters pumping chemotherapeutics out of the cells. For the purposes of this study, we utilized an in vitro model of CSCs, based on cultivation of cells as 3D "spheres". Expression profiling demonstrates that our model of CSCs derived from breast and prostate cancer cell lines express higher mRNA level of ABC transporters, particularly ABCA1, ABCA3, ABCA5, ABCA12, ABCA13, ABCB7, ABCB9, ABCB10, ABCC1, ABCC2, ABCC3, ABCC5, ABCC8, ABCC10, ABCC11 and ABCG2 among the cell lines tested. The protein level of ABC transporters tested in breast CSCs showed higher expression of ABCB8, ABCC1, ABCC2, ABCC10 and ABCG2 but downregulation of ABCB10 and ABCF2 proteins....

Title: Inventory management as prerequisite for an efficient warehousing managementstrategy during expansive growth Authors: Oskar Siggesson, Mattias Hedendahl, Anton Olsson & Max Sandstedt Examinator: Hana HulthénTutor: Petra Andersson Background: The company is in a period of strong growth and is suffering from growingpains. The company is moving to a new location with a larger storage space in 2024 butsomething has to be done before the move. Because of high storage levels there is a lack offree storage space and the warehouse is soon reaching its breaking point. Objective: The report investigates how a change in warehousing strategies can helpMicropower cope with the growth in production until 2024. A forecast is created for thefuture need for storage space on a selection of products in a portion of the warehouse. Methods: This study is a case study of Micropower Group. The study uses secondary data inthe form of quantitative data from the company's business system, but to some extent also theauthor’s own observations. The data is used to perform an ABC/XYZ-analysis on thecompany's incoming inventory that forms the basis for segmentation of the articles. The studyalso conducts a sensitivity analysis of the company's storage space needs. Conclusions: By segmenting articles based on the ABC/XYZ-analysis, appropriateinstruments can be presented for the company's articles. The analysis forms a framework forMicropower's inventory management strategy but also for companies in similar situations.Based on the segmentation, information about the article's characteristics and appropriateinstruments. The study's sensitivity analysis of the forecast for storage space requirementsgives the company an indication of what increase in inventory turnover rate is required tomanage production growth. The study finds that in order to manage production growth therewill need to be an equally large increase in inventory turnover rate. Key words: ABC/XYZ-analysis, item management, inventory management strategy,differentiation, classification, forecast, sensitivity analysis, storage space