No description available.

La barrière hémato-encéphalique (BHE) est une barrière physique qui sépare le sang du parenchyme cérébral. Dues à ses propriétés, la BHE est très sélective et peu perméable. Les cellules qui la composent sont dotées de différents mécanismes de transport adaptés au besoin du système nerveux central (SNC). Jusqu'à présent, l'état de la BHE dans la pathologie Alzheimer a été peu étudié, mais certains indices supposent qu'elle puisse réguler le transport de molécules pathologiques dont le peptide β-amyloïde (Aβ). Nos premiers résultats concernant l'étude de la perméabilité de la BHE suggèrent une diminution du volume vasculaire cérébrale (VvaSc) chez le modèle de souris triple transgéniques (3xTgAD). Notre seconde étude démontre que les protéines ATP-binding cassettes (ABC) pourraient jouer un rôle dans l'efflux du peptide Aβ lors de la maladie d'Alzheimer (MA). Finalement, notre dernière étude suggère que les anticorps monoclonaux (mAb) pourraient servir de vecteurs à la libération de médicament au niveau cérébral

Submitted by Nadir Basilio (nadirsb@uninove.br) on 2018-10-05T14:38:47Z No. of bitstreams: 1 Raquel da Silva Santos.pdf: 5186362 bytes, checksum: 1b02ec8a5495063dd019e582ceddf340 (MD5) / Made available in DSpace on 2018-10-05T14:38:47Z (GMT). No. of bitstreams: 1 Raquel da Silva Santos.pdf: 5186362 bytes, checksum: 1b02ec8a5495063dd019e582ceddf340 (MD5) Previous issue date: 2018-04-27 / Esta investigación se refiere a la presencia de la dimensión internacional en las políticas brasileñas contemporáneas de educación superior, tomando para estudiar la política de internacionalización desarrollada institucionalmente en la Universidad Federal del ABC (UFABC), ubicada en la región metropolitana paulista del Gran ABC, tradicional polo de la industria automovilística y, de organización del sindicalismo obrero. Con un recorte temporal comprendido entre los años 2005, fecha de creación de la institución, a 2017, cuando se realizó la investigación empírica, esta investigación trabajó con la conjetura de que esa universidad forma parte de un conjunto de cambios propuestos por los gobiernos Lula da Sddcilva (2003 -2010) y Dilma Rosseff (2011-2016) que buscaron enfrentar los desafíos y condicionamientos de la formación superior del siglo XXI, marcada por la globalización de mercados, por la idea de sociedad del conocimiento y por la organización y difusión de rankings. El objetivo del trabajo es comprender los fundamentos teórico-políticos que orientan la misión de estos nuevos modelos de universidad en Brasil, con un enfoque particular en la política interna de internacionalización de la UFABC. Las referencias teóricas utilizadas son los investigadores que debaten la educación superior en registro contra hegemónico, en la tensión que se establece entre dos macroestrategias de internacionalización de la educación superior, la cooperativa y la competitiva, y que impactan políticas y sistemas de educación superior en Brasil. Proponemos una investigación de naturaleza cualitativa que utiliza el ciclo de políticas de Ball y Bowe (1992) como enfoque metodológico de análisis de política pública, y la entrevista como procedimiento metodológico de recolección de datos, teniendo como sujetos de investigación formuladores del proyecto institucional de la UFABC , sus gestores y agentes de internacionalización. En el marco del Proyecto "Universidad Popular en Brasil" (Capes-Obeduc), además del recurso a una revisión bibliográfica sobre educación popular e internacionalización universitaria, utilizamos el acervo de testimonios recogidos en universidades del mismo tipo investigadas en el marco del Proyecto "Universidad Popular en Brasil" (Capes-Obeduc), además del recurso a una revisión bibliográfica sobre educación popular e internacionalización universitaria. Los datos recolectados fueron analizados por medio de la técnica de Análisis del Discurso, teniendo Orlandi (2009) como referencia más significativa. Las conclusiones principales de este estudio indican que la política de internacionalización de la UFABC atiende las recomendaciones del Banco Mundial en lo que concierne a la estructura de las World Class Universities, como fundamento teórico político, contribuyendo a la inserción de la UFABC en el escenario internacional por el sesgo de la internacionalización competitiva, las demandas de la globalización del mercado. / This research refers to the presence of the international dimension in contemporary Brazilian policies of higher education, taking to study the internationalization policy developed institutionally at the Federal University of ABC (UFABC), located in the metropolitan region of Grande ABC, a traditional hub of the automobile industry and organization of workers' unionism. With a temporal cut from the year 2005, when the institution was created, to 2017, when the empirical research was carried out, this research worked with the conjecture that this university is part of a set of changes proposed by the governments Lula da Sddcilva (2003) -2010) and Dilma Rosseff (2011-2016) who sought to face the challenges and constraints of 21st century higher education, marked by the globalization of markets, the idea of a knowledge society and the organization and dissemination of rankings. The objective of this work is to understand the theoretical-political foundations that guide the mission of these new university models in Brazil, with a particular focus on the internationalization policy of UFABC. The theoretical references used are the researchers who debate higher education in a counter-hegemonic register, in the tension that is established between two macro strategies of internationalization of higher education, the cooperative and the competitive one, and that impact policies and systems of higher education in Brazil. We propose a research of a qualitative nature that uses Ball and Bowe's policy cycle (1992) as a methodological approach to public policy analysis, and the interview as a methodological procedure for data collection, having as research subjects formulators of the UFABC institutional project , its managers and internationalization agents. We also used the collection of testimonies collected in universities of the same type researched in the scope of the "Popular University in Brazil" Project (Capes-Obeduc), in addition to the bibliographical revision on popular education and university internationalization. The collected data were analyzed through the Discourse Analysis technique, with Orlandi (2009) being the most significant reference. The main conclusions of this study indicate that the internationalization policy of UFABC complies with the recommendations of the World Bank regarding the structure of the World Class Universities, as a theoretical political foundation, contributing to the insertion of UFABC in the international scenario through the competitive internationalization bias, demands of globalization of the market. / Esta pesquisa se refere à presença da dimensão internacional nas políticas brasileiras contemporâneas de educação superior, tomando para estudo a política de internacionalização desenvolvida institucionalmente na Universidade Federal do ABC (UFABC), localizada na região metropolitana paulista do Grande ABC, tradicional polo da indústria automobilística e de organização do sindicalismo operário. Com recorte temporal compreendido entre os anos de 2005, data de criação da instituição, a 2017, quando realizada a investigação empírica, esta pesquisa trabalhou com a conjectura de que essa universidade faz parte de um conjunto de mudanças propostas pelos governos Lula da Silva (2003-2010) e Dilma Rousseff (2011-2016) que buscaram enfrentar os desafios e condicionamentos da formação superior do século XXI, marcada pela globalização de mercados, pela ideia de sociedade do conhecimento e pela organização e difusão de rankings. O objetivo do trabalho é compreender os fundamentos teórico-políticos que orientam a missão desses novos modelos de universidade no Brasil, com foco particular na política interna de internacionalização da UFABC. As referências teóricas utilizadas são os pesquisadores que debatem a educação superior em registro contra hegemônico, na tensão que se estabelece entre duas macroestratégias de internacionalização do setor, a cooperativa e a competitiva, e que impactam políticas e sistemas de educação superior no Brasil. Propomos uma investigação de natureza qualitativa que utiliza o ciclo de políticas de Ball e Bowe (1992) como abordagem metodológica de análise de política pública, e a entrevista como procedimento metodológico de coleta de dados, tendo como sujeitos de pesquisa os gestores e agentes de internacionalização da UFABC. Utilizamos, ainda, o acervo de depoimentos coletados em universidades de mesmo tipo pesquisadas no âmbito do Projeto “Universidade Popular no Brasil” (Capes-Obeduc), além do recurso a uma revisão bibliográfica sobre internacionalização da educação superior brasileira. Os dados coletados foram analisados por meio da técnica de Análise do Discurso, tendo Orlandi (2009) como referência mais significativa. As conclusões principais deste estudo indicam que a política de internacionalização da UFABC atende às recomendações do Banco Mundial e busca a inserção da instituição no cenário internacional a partir dos fundamentos teórico-políticos das chamadas World Class Universities, constituindo, portanto, um processo de internacionalização competitiva que tem os mercados globalizados como foco.

Bakgrund: För företag som håller lager är en viktig faktor för att lyckas öka effektiviteten att arbeta med lagerstyrning. Lagerstyrning handlar om planering och kontroll av lagret för att kunna serva kunderna och produktionen. Inom lagerstyrning är det viktigt att företag fattar beslut gällande vilken orderkvantitet som ska beställas samt när ordern ska läggas för att finnas tillgänglig på lagret vid rätt tidpunkt. Företag kan använda sig av säkerhetslager vid styrning av sitt lager för att försäkra sig om att de kan hantera osäkerheter i efterfrågan och produktion. Syfte: Syftet med studien är att utifrån analys av lagerstyrningsteori utforma en teoretisk lagerstyrningsmodell för att skapa förståelse för hur lageromsättningshastigheten kan öka. Vidare ska den framtagna modellen empiriskt appliceras på Sandviks produktionsavdelning i Svedalas aktuella artiklar för att identifiera möjliga förbättringar. Metod: Studien har genomförts som en fallstudie på Sandviks produktionsavdelning i Svedala baserat på en teoretisk framtagen lagerstyrningsmodell. Teoriinsamlingen till utformandet av den teoretiska lagerstyrningsmodellen har inhämtats via facklitteratur och vetenskapliga artiklar. Empiriinsamlingen har gjorts med hjälp av intervjuer och numerisk data. Både teori och empiri har sedan analyserats utifrån ett kvalitativt tillvägagångssätt. Avslutande kommentarer: Den framtagna teoretiska lagerstyrningsmodellen börjar med att presentera kriterier som påverkar lageromsättningshastigheten, sedan presenteras steg för att genomföra en ABC-klassificering och slutligen presenteras olika lagerstyrningsmetoder för att bestämma hur orderläggningen ska ske samt hur stortivsäkerhetslagret ska vara. Den teoretiska lagerstyrningsmodellen är pedagogisk och tydlig för att skapa förståelse hos företag om hur de kan öka sin lageromsättningshastighet. Lagerstyrningen som formades utifrån den teoretiska lagerstyrningsmodellen för Sandviks produktionsavdelning i Svedala bestod av orderläggningsmetoderna lot-for-lot, uppskattad orderkvantitet och täcktidplanering samt säkerhetslager baserat på manuella bedömningar och baserat på ledtidsförbrukningen. Med hjälp av denna lagerstyrning ska de proaktivt undvika föråldrat och långsamtgående lager i framtiden. / Background: In order to increase the efficiency for companies that keep inventory, they need to work with inventory control. Inventory control regards planning and control of the inventory to increase customer and production service. Within inventory control, it is important that companies make decisions regarding the quantity to be ordered and when the order will be added to be available in the warehouse at the right time. Companies can use safety stock to ensure that they can deal with uncertainties in demand and production. Purpose: The purpose of this study is, based on analysis of inventory control theory, to design a theoretical model of inventory control to create an understanding for how the inventory turnover may increase. Furthermore, the theoretical model will be empirically applied to Sandvik's production department of Svedala's current articles to indicate improvements. Method: The study has been made as a case study at Sandvik´s production department in Svedala, based on a developed theoretical model of inventory control. Theory collection to the design of the theoretical model of inventory control has been obtained through professional literature and scientific articles. Empirical data has been collected through interviews and numerical data. Both theory and empirical data have been analyzed from a qualitative approach. Concluding remarks: The designed theoretical model of inventory includes criteria that affect inventory turnover, the steps to implement an ABC classification and various inventory control methods to determine how the placement of orders should be implemented and the amount of safety stock that should be held. The theoretical model vi of inventory control is pedagogical and clear to create an understanding regarding how companies can increase their inventory turnover. The inventory control that was formed for Sandvik´s production department in Svedala, on the basis of the theoretical model of inventory control, consisted of the ordering methods, lot-for-lot, estimated order quantity and cover-time planning. The methods for safety stock were safety stock based on manual assessments and on lead time consumptions. With this control Sandvik´s production department in Svedala, proactively can avoid obsolete and slow moving inventory in the future

Thesis (M Sport Sc (Sport Science))--University of Stellenbosch, 2005. / The purpose of this study was to determine the effectiveness of a perceptual-motor development programme for children with Developmental Coordination Disorder (DCD), as identified on the Movement Assessment Battery for Children (M-ABC). A pre- and post-test design was employed in the study and data were reported as case studies. The programme included a cognitive approach to perceptual-motor activities, with special attention to visual perception. The intervention programme was implemented over six consecutive weeks, with two 45-minute sessions each week. The motor proficiency of nine of the 12 children who participated in this study improved to the point where they were no longer classified as having DCD. The reasons for this improvement could be attributed to the regular practise provided by the perceptual-motor activities that were the content of the program and to the method of presentation, i.e. the cognitive strategies that were child-centred, which could have helped develop self-confidence in the children. These results are in agreement with the research of Schoemaker and Kalverboer (1994) that many children with DCD may learn to overcome or cope with their movement problems. The three children who performed most poorly on the M-ABC pre-test did not improve over the course of the intervention programme. A thorough examination of their perceptual-motor system could provide more information about the various factors that may contribute to their movement problems. It is also possible that the programme simply was not long enough for these children (they did not get enough practise) and/or they were not able to respond to the child-centred cognitive approach in such a short period of time.

Les acides dicarboxyliques (DCA) sont des composés de base pour la production de polymères, plastiques, lubrifiants, antibiotiques et parfums. Bien que de grand intérêt, les DCA qui comportent une chaîne aliphatique supérieure à douze atomes de carbone sont difficilement synthétisables par la voie chimique. L'objet de cette étude est de développer un procédé biotechnologique pour produire ces composés par bioconversion de matières premières renouvelables (huile de tournesol oléique) via la levure Yarrowia lipolytica. <br />Chez les souches sauvages, les acides gras sont principalement dégradés par la voie de la Β-oxydation. Nous avons bloqué la première étape de la Β-oxydation par disruption séquentielle des six gènes codant les acyl-CoA oxydases permettant ainsi de réorienter le flux d'acides gras vers l'ω-oxydation qui conduit à la production de DCA. L'amélioration de la production des DCA a été obtenue par l'augmentation de l'activité d'hydroxylation, impliquée dans l'ω-oxydation, en surexprimant les gènes codant la NADPH cytochrome P450 réductase et les 12 cytochromes P450. Néanmoins, la moitié du substrat s'accumule dans les corps lipidiques. Ce stockage a été réduit, par disruption de gènes, entraînant ainsi une augmentation du rendement de bioconversion.<br />Enfin, l'étude de mutants d'insertion a révélé l'implication de 5 ABC transporteurs PDR qui confèrent la résistance aux drogues. L'étude fonctionnelle de cette famille a démontré que le transporteur Abc1p serait un exporteur membranaire spécifique des alcanes à longue chaîne carbonée, constituant le premier ABC transporteur PDR responsable de l'export de molécules physiologiques. <br /> Ces travaux ont permis de développer une souche améliorée de Y. lipolytica pour la production de DCA à partir d'huiles végétales.

生技產業乃二十一世紀的十大重要產業之第一位，而台灣雄厚電子產業的發展根基，非常適合發展生物科技領域中之醫療器材產業，而電子醫療器材產品與一般電子產品最大的不同處，在於產品開發期較長，尤其在驗證與確效上的作業最為繁複，往往臨床驗證所花費的資源比實際開發設計工作更多，除少數家用電子醫療器材產品外，皆具少量多樣之產品特性，以台灣在電子產業研發技術的實力，加上業界快速應變能力，公、私部門若能投入更多資源，則產業榮景可期。 基於產業特性之不同，歷年來有許多有關作業基礎成本制產業別適用性之研究，但卻少有對醫療器材產業之適用有深入的研究。因此本研究將經由個案實例，建構與導入作業基礎成本制度，確認作業基礎成本制度是否適用於醫療器材產業，並探討醫療器材產業研發部門導入作業基礎成本制度時之相關事項。 本研究擬以國內某一上市櫃之醫療電子廠商為研究對象，以個案研究之方式，探討以下主題: 1. 作業基礎成本制度是否適用於醫療器材產業。 2. 為個案公司研發管理流程建構作業基礎成本制度。 3. 經由建構與導入作業基礎成本制度嘗試分析找出最佳動因之方法與相關應注意事項。 4. 經由建構與導入作業基礎成本制度分析動因選定與資料收集效率之間的平衡取捨。 / Biotechnology is at the apex of the top-ten industries list of the 21st century. The profound foundation of electronics in Taiwan is suitable for the development of medical equipment industry in the field of biotechnology. Long product development time is the trait that separates electronic medical products from electronics (consumer, IT ,etc) , especially, the complicated and lengthy validation and certification process. The process of clinical testing consumes more resources in comparison to actual product development and design. Except for homecare device, medical equipment is small in volume and big in diversity. In addition to R&D capability and quick response to market, Taiwan’s electronics industry will be able to achieve more if additional resources are invested. Each industry is unique in its own way. There are many studies furnished on activity-based costing system of various industries ,but they are lacking for medical equipment industry. It is the attempt of this research to construct and introduce activity-based costing system with a case study in order to confirm whether the activity-based costing system is applicable for medical equipment industry and what the influences of activity-based costing system on medical equipment industry. 1. Whether the activity-based costing system is applicable for medical equipment industry or not? 2. Construct an activity-based costing system for R&D management procedure of the subject in this research. 3. Try to analyze and seek for the best driver by constructing and introducing an activity-based costing system. 4. Try to analyze the balance between driver selection and data collection efficiency by constructing and introducing an activity-based costing system.

Phytohormone auxin plays an important role in regulating plant development. Directional (polar) cell-to-cell auxin transport creates auxin gradients within plant tissues, which trigger a specific developmental response. The vast majority of available data concerns angiosperms. Lower land plants have been much less explored in this regard, but the important auxin-related mechanisms (including polar auxin transport) are already present in mosses. To uncover the origins of auxin action, one must focus on green algae, especially of clade Streptophyta, which are the direct ancestors of all land plants. In this study, the possible effects of auxins, both native and synthetic, were investigated on two algae: basal, unicellular Chlorella lobophora and advanced, filamentous Spirogyra sp. The latter received comparably more attention, since it belongs to a clade now acknowledged as a sister group to land plants. Chlorella lobophora culture growth was irresponsive to synthetic auxin NAA. The average Spirogyra sp. cell length was, however, changed by auxins at high concentrations. By conducting accumulation assays of radioactively labelled auxins and HPLC analysis, auxin metabolism and transport was investigated in Spirogyra sp. This alga was able to metabolize the plant-native IAA, but not synthetic auxins...

Made available in DSpace on 2016-04-25T18:39:39Z (GMT). No. of bitstreams: 1 Anderson Alvares.pdf: 2247051 bytes, checksum: 0ebe5955afba8838ebd0743301cf478c (MD5) Previous issue date: 2011-05-25 / The knowledge of the customer profitability is important information to define specific policies and actions. The profitability analysis indicates the portion of profit that each customer contributes to the result of the company. Customers have different needs and therefore consume company resources differently. Measuring the Cost to Serve answers to the company how much it costs to serve each customer, distribution channel, region etc. The Activity Based Costing (ABC) came in the late 80s, with the aim of measuring the cost of products, customers and other costing objects with greater accuracy, thus avoiding distortions caused by the use of criteria for apportionment, based on volume, the allocation of indirect costs. However, even with the benefits provided by ABC, many companies withdrew their application in practice, pointing out several difficulties. Kaplan and Anderson (2004) presented as a solution to the difficulties encountered in using the ABC, Activity Based Costing and Time (TDABC), whose purpose is to simplify the costing process, using time as a major driver of costs. In that sense, this paper presents an exploratory case study with a single company in the food industry, located in São Paulo. We analyzed the 248 enterprise customers in order to verify if the TDABC can simplify the measurement of the cost of processing applications and provide relevant information to the analysis of customer profitability. The paper presents as the main objective the use and analysis of TDABC in measuring the cost of processing applications. In general, the study showed that TDABC can simplify the process of costing, however, care is needed to calculate the rate of capacity cost and the development of equations of time. Whereas the findings and results of this study were obtained from a single company, it is suggested to future researchers to apply the subject in companies in other sectors / O conhecimento da lucratividade do cliente é uma informação relevante para a definição de ações e políticas específicas. A análise da lucratividade indica a parcela com que cada cliente contribui para o resultado da empresa. Os clientes apresentam necessidades diversas e, consequentemente, consomem recursos da empresa de forma diferente. A mensuração do Custo para Servir responde à empresa quanto custa servir cada cliente, canal de distribuição, região etc. O Custeio Baseado em Atividade (ABC) surgiu no final dos anos 80, com o objetivo de mensurar o custo dos produtos, clientes e de outros objetos de custeio com maior acurácia, evitando, assim, distorções causadas pela utilização de critérios de rateio, baseados no volume, na alocação dos custos indiretos. Entretanto, mesmo com os benefícios proporcionados pelo ABC, muitas empresas desistiram de sua aplicação na prática, apontando diversas dificuldades. Kaplan e Anderson (2004) apresentaram como solução às dificuldades encontradas na utilização do ABC, o Custeio Baseado em Atividade e Tempo (TDABC), cujo propósito é simplificar o processo de custeio, usando o tempo como principal direcionador de custos. Nesse sentido, esta dissertação apresenta uma pesquisa exploratória com estudo de caso único numa empresa do setor alimentício, localizada no estado de São Paulo. Foram analisados os 248 clientes da empresa no intuito de verificar se o TDABC pode simplificar a mensuração do custo do processamento dos pedidos e proporcionar informações relevantes na análise da lucratividade dos clientes. A dissertação apresenta como objetivo principal a utilização e análise do TDABC na mensuração do custo do processamento dos pedidos. Em linhas gerais, o estudo demonstrou que o TDABC pode simplificar o processo de custeio, entretanto, é necessário cuidado no cálculo da taxa do custo da capacidade e na elaboração das equações de tempo. Considerando que as conclusões do estudo e os resultados desta pesquisa foram obtidos de uma única empresa, sugere-se aos futuros pesquisadores que o tema seja aplicado em empresas de outros setores

Orientadora: Profa. Dra. Neusa Serra / Dissertação (mestrado) - Universidade Federal do ABC, Programa de Pós-Graduação em Ciências Humanas e Sociais, 2013.