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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
111

Interpretace výskytu ztrát míče v basketbalu mládeže v České republice / Interpretation of violations and offesive fouls in the youth basketbal

Musil, Jan January 2019 (has links)
Title: Interpretation of the occurence turnovers in youth basketbal in Czech republic. Objectives: Our goal is to assess the degree forced and unforced turnovers in basketball matches in two age categories. Our assumption is that the in the higher category, the occurrance of unforced turnovers is lower. Methods: Method of work is indirect observation of videos, analysis and creation of quantitative research on teams category U15 and U19, then a detailed analysis of the number and type of turnovers of individual categories and matches follows. Results: We found that younger category reached a larger number of unforced turnovers and forced turnovers too. Turnovers were caused primarily from the mistakes of the players.Both categories reached more forced turnovers. The possible solution is emphasis on the development of individual game performance in practice. Keywords: youth basketball, team game performance, quantitative analysis, turnovers
112

Biodiversidade de mosca-das-frutas do gênero Anastrepha (Diptera, Tephritidae) no campus Luiz de Queiroz, Piracicaba, São Paulo. / Biodiversity of anastrepha fruit flies (dip., tephritidae) on the luizde queirozcampus, Piracicaba, São Paulo.

Uramoto, Keiko 12 July 2002 (has links)
Este trabalho foi conduzido na área abrangida pelo campus Luiz de Queiroz/Universidade de São Paulo, no município de Piracicaba, Estado de São Paulo. Teve como objetivos, determinar a composição do gênero Anastrepha Schiner, sua distribuição e a análise quantitativa da população. Além disso, verificou-se a relação da flutuação populacional com variáveis bióticas e abióticas e a associação das espécies de plantas hospedeiras, estabelecidas na área, com as espécies de Anastrepha.Foram examinadas 23.263 fêmeas de Anastrepha coletadas em armadilhas McPhail e 18 espécies pertencentes a 9 grupos infragenéricos foram assinaladas. A distribuição das fêmeas por armadilha foi fortemente agregada, com 5 armadilhas (6%) capturando 50% do total de fêmeas. Apenas A. fraterculus (Wiedemann) e A. obliqua (Macquart) foram dominantes. A. fraterculus foi a espécie mais freqüente, representando 80,2% do total de fêmeas capturadas no campus e a mais constante ocorrendo em 98,04% das amostras. Em ordem decrescente de freqüência, seguiram-se A. obliqua (12,6%), A. pseudoparallela (Loew) (3,1%) e A. bistrigata Bezzi (2,1%). As demais espécies apresentaram freqüência menor que 1%. O valor elevado do índice de Simpson (0,66) e os valores baixos do índice de Shannon (0,7521) e de eqüitatividade (0,459) resultaram da alta freqüência de A. fraterculus. Um aumento no nível populacional das espécies de Anastrepha ocorreu de agosto a novembro com um pico máximo em setembro. A disponibilidade de frutos hospedeiros foi mais determinante na variação do tamanho da população das espécies mais abundantes de Anastrepha que as variáveis climáticas. Um total de 565 amostras de frutos pertencentes a 11 famílias e, pelo menos, 25 espécies botânicas foi coletado em 47 estações de capturas. Foram identificadas 10.290 fêmeas e das 18 espécies de Anastrepha capturadas em armadilhas somente 6 emergiram das amostras de frutos: A. bistrigata Bezzi, A. fraterculus (Wiedemann), A. obliqua (Macquart), A. pseudoparallela (Loew), A. serpentina (Wiedemann) e A. sororcula Zucchi. A. fraterculus foi a espécie que infestou maior diversidade de frutos. Os hospedeiros preferidos de A. obliqua foram as espécies da família Anacardiaceae. A. pseudoparallela e A. serpentina infestaram exclusivamente Passifloraceae e Sapotaceae, respectivamente. Uma nova associação de mosca-das-frutas com planta hospedeira foi constatada: A. fraterculus em Syagrus romanzoffiana (Cham.) Glassman (coquinho). Foi reportado o primeiro registro da associação de A. fraterculus em Manilkara zapota L. (sapoti) no Brasil. / This study was conducted in the Luiz de Queiroz campus of the Universidade de São Paulo, in Piracicaba, state of São Paulo. The aim of this study was to determine the number of species in the genus Anastrepha Schiner on campus, their distribution and the quantitative analysis of the population. Moreover, this study correlated populational fluctuations with biotic and abiotic factors as well as the association between host plant species and the Anastrepha species in that area. A total of 23,263 females of Anastrepha collected in MacPhail traps was examined, and 18 species belonging to nine infrageneric groups were registered. The distribution of females per trap was strongly clustered, with 5 traps (6%) capturing 50% of the total of females. Only A. fraterculus (Wiedemann) and A. obliqua (Macquart) were considered dominant species. A. fraterculus was by far the most frequent species, representing 80.2% of the total of females captured on campus, and the most constant, occurring in 98.04% of the analyzed samples. In decreasing order of frequency, A. obliqua (12.6%), A. pseudoparallela (Loew) (3.1%), and A. bistrigata Bezzi (2.1%) comprised the other major species. The remaining species showed frequency lower than 1%. The high value of the Simpson’s index (0.66) as wel as the low values of Shannon’s index (0.7521) and the equitability index (0.459) resulted from the high frequency of A. fraterculus. The populational level of Anastrepha increased from August to November with the highest peak in September. The availability of host fruit, more than climatic parameters determined most of the variation of population size in the most abundant species of Anastrepha. A total of 565 fruit samples representing at least 25 plant species from 11 families was collected in 47 capture sites. 10,290 females were identified. Of the 18 Anastrepha species captured in traps, only 6 also emerged from fruit samples: A. bistrigata Bezzi, A. fraterculus (Wiedemann), A. obliqua (Macquart), A. pseudoparallela (Loew), A. serpentina (Wiedemann) e A. sororcula Zucchi. A. fraterculus infested the greatest diversity of hosts. The preferred hosts of A. obliqua were plant species in the family Anacardiaceae. A. pseudoparallela and A. serpentina infested only species in the families Passifloraceae and Sapotaceae, respectively. A new fruit fly and host plant association was registered: A. fraterculus with Syagrus romanzoffiana (Cham.) Glassman (queen palm). The association of A. fraterculus with Manilkara zapota L. (sapodilla) was reported here for the first time in Brazil.
113

Gestão de design : uma análise quantitativa em empresas brasileiras listadas no ranking If Design

Moura, Janine Barbosa. 03 September 2009 (has links)
Submitted by Silvana Teresinha Dornelles Studzinski (sstudzinski) on 2015-03-21T00:34:54Z No. of bitstreams: 1 00000740.pdf: 1980084 bytes, checksum: 225c934ee7c428947b520fc116b828fd (MD5) / Made available in DSpace on 2015-03-21T00:34:54Z (GMT). No. of bitstreams: 1 00000740.pdf: 1980084 bytes, checksum: 225c934ee7c428947b520fc116b828fd (MD5) Previous issue date: 2009-09-03 / Nenhuma / A Gestão de Design tem recebido atenção da academia e vem sendo delineada como uma nova área de atuação em ambientes de produção, como meio para sustentar inovações, diferenciar produtos em relação à concorrência e gerar oportunidades de ganhos, contribuindo para melhorar o desempenho empresarial. A Gestão de Design explora a integração de diferentes atividades em um processo interdisciplinar que influencia a estratégia da organização, pensando e concebendo formas alternativas para gerar soluções inovadoras e sustentáveis. O objetivo desta pesquisa é analisar a Gestão de Design nas empresas brasileiras embasado em uma análise quantitativa a partir de um a população de 43 empresas brasileiras identificadas por excelência em design. Para dar suporte à pesquisa os principais aspectos que envolvem a Gestão de Design foram identificados por meio de uma revisão teórica dos conceitos associados a essa temática. A revisão permitiu elencar hipóteses a serem testadas, associadas a constructos representativos da Gestão de Design. O método utilizado foi o levantamento (survey) e os dados coletados foram submetidos a análises estatísticas, que permitiram a validação das hipóteses construídas para a população estudada. O estudo indica que as empresas que têm se destacado em design alcançaram um nível de maturidade em relação ao tema e percebem a importância da Gestão de Design para a empresa não necessariamente em função de seu porte ou tempo de mercado. / The Design Management has received attention from academia and has been outlined as a new area in production environments as a means to support innovation, differentiate products from competitors and generate revenue opportunities, contributing to improve business performance. The Design Management explores the integration of different activities in an interdisciplinary process that influences the organization's strategy, creating and developing alternative ways to generate innovative and sustainable solutions. The objective of this research is to analyze the Design Management in Brazilian companies based on aquantitative analysis from a population of 43 Brazilian companies identified for the excellence in design. To support the research the main aspects involved in the Design Management were identified through a review of theoretical concepts associated with this theme. The review helped to identify hypotheses to be tested, associated with constructs representative of Design Management. The method use dwas a survey and the data collected were subjected to statistical analysis, which allowed the validation of the hypotheses for this population. The study indicates that companies that have gained notoriety in design have achieved a level of maturity over the issue and have realized that the importance of Design Management for the company is not necessarily a function of size or time in the market.
114

Caracterização clínica, laboratorial e da composição de urólitos em felinos domésticos / Clinical, laboratory characterization and composition of uroliths in domestic felines

Gomes, Veridiane da Rosa 19 February 2018 (has links)
Submitted by Erika Demachki (erikademachki@gmail.com) on 2018-03-29T19:21:32Z No. of bitstreams: 2 Dissertação - Veridiane da Rosa Gomes - 2018.pdf: 2765105 bytes, checksum: c057139a9b5403263960909e06b08a8b (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) / Approved for entry into archive by Erika Demachki (erikademachki@gmail.com) on 2018-03-29T19:23:56Z (GMT) No. of bitstreams: 2 Dissertação - Veridiane da Rosa Gomes - 2018.pdf: 2765105 bytes, checksum: c057139a9b5403263960909e06b08a8b (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) / Made available in DSpace on 2018-03-29T19:23:56Z (GMT). No. of bitstreams: 2 Dissertação - Veridiane da Rosa Gomes - 2018.pdf: 2765105 bytes, checksum: c057139a9b5403263960909e06b08a8b (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Previous issue date: 2018-02-19 / Conselho Nacional de Pesquisa e Desenvolvimento Científico e Tecnológico - CNPq / The dissertation is divided into two chapters, the first one is a bibliographical review about urinary lithiasis in felines and the second chapter a scientific article reporting epidemiological, clinical and laboratory characterization of urolithiasis in felines. Urinay calculi of 42 felines attended in Veterinary teaching Hospital of Federal University of Goias (HV/EVZ/UFG) and other private veterinary clinics and hospitals were assessed using chemical analysis and energy dispersive spectroscopy (EDS). The most observed mineral was struvite (38,1%), followed by ammonium urate (35,7%) and calcium oxalate (26,2%). The males were more affected (26/42), as well mixedbreed animals (36/42). Animals aged between 25 and 72 months old were the most affected (27/42). In 33 cases (78,6%) the stones were recovered of bladder. The clinical signs with most occurrence were dysuria (65,0%), hematuria (50,0%), vomiting (17,5%) and anorexia (12,5%). Of the 42 felines studied, 39 (92.8%) were neutered. Regarding feeding, 26 (61.9%) cats received dry rations exclusively, while 13 (38.1%) received dry and wet rations. Despite the higher occurrence of struvite uroliths, a significant presence of ammonium urate uroliths was observed, which highlights the importance of studies on feline disease. The urolithiasis in cats is little studied in our country and the present work is a pioneer in the analysis of calculations in felines in Brazil, mainly due to the use of techniques of quantitative analysis, such as the dispersive energy spectroscopy. / A dissertação está dividida em dois capítulos, sendo o primeiro uma revisão bibliográfica sobre a litíase urinária em felinos e o segundo capítulo um artigo científico onde objetivou-se caracterizar epidemiológica, clínica e laboratorialmente a urolitíase em felinos. Cálculos urinários de 42 gatos atendidos no Hospital Veterinário da Escola de Veterinária e Zootecnia da Universidade Federal de Goiás (HV/EVZ/UFG) e em clínicas e hospitais veterinários de diferentes regiões do país foram analisados por meio de técnica de análise química, e espectroscopia de energia dispersiva (EDS). A estruvita foi o mineral mais observado (38,1%), seguido de urato amônio (35,7%) e oxalato de cálcio (26,2%). Os machos foram mais acometidos (26/42), bem como os animais sem raça definida (36/42). Animais com idade entre 25 e 72 meses tiveram maior representação (27/42). Em 33 casos (78,6%) os cálculos foram recuperados da bexiga. Os sinais clínicos de maior ocorrência foram disúria (65,0%), hematúria (50,0%), vômito (17,5%) e anorexia (12,5%). Dos 42 felinos estudados, 39 (92,8%) eram castrados. Quanto a alimentação, 26 (61,9%) gatos recebiam exclusivamente ração seca, enquanto que 13 (38,1%) recebiam associação de ração seca e úmida. Apesar da maior ocorrência de urólitos de estruvita, foi observada significativa presença de urólitos de urato amônio o que ressalta a importância de estudos sobre a enfermidade na espécie felina. A urolitíase em gatos é pouco estudada em nosso país e o presente trabalho é pioneiro na análise de cálculos em felinos no Brasil, especialmente pelo uso de técnicas de análise quantitativa, como a espectroscopia de energia dispersiva.
115

Développement d'un dispositif de LIBS pour l'analyse quantitative en ligne des procédés de purification du silicium fondu / Development of a LIBS device for inline quantitative analysis during silicon melt purification

Patatut, Loïc 15 December 2015 (has links)
L’objectif de ce travail de thèse a été de développer et de valider une méthode d’analyse quantitative du silicium liquide par la technique LIBS (Laser Induced Breakdown Spectroscopy). Pour cela, le dispositif utilisé consiste en une mesure intrusive sur la surface de bulles gazeuses, générées au cœur du métal fondu par soufflage d’un gaz inerte au travers d’un tube. Dans un premier temps, les conditions d’acquisition du signal ont été optimisées pour permettre la répétabilité et la reproductibilité du signal LIBS en dépit des fluctuations paramétriques induites par le bullage. Dans un second temps, les paramètres expérimentaux affectant les propriétés physiques des plasmas produits ont été évalués pour maximiser la sensibilité de la mesure et réduire les limites de détection. Les deux paramètres clefs qui ont été identifiés sont la densité de puissance apportées par l’impulsion laser et la nature du gaz de bullage : l’intensité du signal et donc le nombre d’émetteurs dans les plasmas sont favorisés par les hautes énergies laser et par une atmosphère d’argon plutôt que d’hélium. Le diagnostic spectroscopique des plasmas générés en fonction de ces paramètres a permis de montrer qu’ils n’ont pas d’effet significatif sur la température des électrons, des ions et des espèces neutres. L’augmentation de masse ablatée par le laser et la modification des conditions de relaxation du plasma par le milieu ambiant sont les mécanismes majoritaires à considérer. Finalement un modèle d’analyse quantitatif a été construit dans les conditions optimisées pour les impuretés B, Al, Fe, Cu et Ti du silicium. Il permet d’atteindre des limites de détection qui vont de quelques ppmw pour les éléments B, Fe et Al jusqu’à moins de 0,5 ppmw pour le Cu et le Ti. Les concentrations prédites par LIBS présentent un très bon accord avec celles déterminées par une méthode ex-situ conventionnelle, l’ICP-OES, avec des écarts relatifs inférieurs en moyenne à 10 %. Ceci démontre l’intérêt de la technique LIBS pour contrôler in-situ et en temps réel un procédé d’élaboration du silicium photovoltaïque. / The aim of this PhD research work was to develop and to validate a quantitative method to measure the composition of molten silicon by Laser Induced Breakdown Spectroscopy (LIBS). The device used consists in an intrusive measurement on the surface of gas bubbles which are produced by blowing an inert gas through a pipe inserted into the melt. First, the signal acquisition conditions were optimized to ensure LIBS signal repeatability and reproducibility to overcome experimental fluctuations due to the bubbling. Second, the experimental parameters affecting plasma physics were evaluated to maximize the measurement sensitivity and to lower the limits of detection. The two key parameters identified are the laser power density and the ambient gas: the signal intensity and then the number of emitters inside the plasma are promoted by higher laser energy and an Ar atmosphere rather than a He one. The plasma spectroscopic diagnosis as a function of these parameters showed that they don’t have significant effect on the temperature of electrons, ions and neutral species. The only mechanisms to be considered are then the increase of the mass ablated by the laser and the modification of the plasma relaxation conditions by the ambient atmosphere. Third, calibration curves were established for B, Al, Fe, Cu and Ti impurities under the optimized conditions. Limits of detections from few ppmw for B, Fe and Al to less than 0,5 ppmw for Ti and Cu have been achieved. The predicted concentrations by LIBS are in very good agreement with the ones measured by the conventional ex-situ method, ICP-OES. The mean relative discrepancy is lower than 10 %. These results demonstrate the LIBS benefits for in-situ and in-line monitoring of photovoltaic silicon production processes.
116

Quantitative analysis of multi-phase systems -steels with mixture of ferrite and austenite

Fawad, Salman Kohar January 2004 (has links)
<p>The goal of this work has been to evaluate the different experimental techniques used for quantitative analysis of multi-phase materials systems. </p><p>Powder based specimens containing two-phases, austenite and ferrite , were fabricated and quantified. The volume fraction of ferrite varied from 2 Vol% to 50 Vol%. </p><p>X ray powder diffraction (XRD) measurements were based on two peak analysis. Computer based software Topas was used for quantitative analysis, which is believed to be the most advanced in this field. XRD results were found within the absolute limit of +/- 4% of given ferrite volume fraction. Volume fraction as low as 2 Vol% was successfully detected and quantified using XRD. However, high statistical error was observed in case of low volume fraction, such as 2 Vol% and 5 Vol% ferrite volume fraction. </p><p>Magnetic balance (MB) measurements were performed to determine the volume fraction of magnetic phase, ferrite. MB results were found in good agreement with given volume fractions. As low as 2 Vol% volume fraction was detected and quantified with MB. MB results were within the absolute limit of +/- 4% of given ferrite volume fraction. </p><p>Image analysis (IA) was performed after proper sample preparation as required by electron backscatter diffraction (EBSD) mode of Scanning electron microscopy (SEM). IM results were found within the absolute limit of +/- 2 % of given ferrite volume fraction. However, high statistical error was observed in case of 2 Vol% volume fraction.</p>
117

Var är brudarna? : En innehållsanalytisk studie om kvinnliga idrottsutövare i Sportbladet / Where are the chicks? : A content analytic study about female athletes in Sportbladet

Carlén, Fredrik, Dillenz, Mikael January 2009 (has links)
<p>The goal with our research has been to describe how often and in what way female athletes are represented in the sport section in Sweden’s biggest evening newspaper Aftonbladet. The material we’ve used are the newspapers that we collected during two weeks in 2008, the 3<sup>rd</sup> of November to the 9<sup>th</sup> of November and the 11<sup>th</sup> of November to the 17<sup>th</sup> of November. We’ve conduced two qualitative researches – a text analysis and an image analysis – and one quantitative analysis on our material. We’ve based our analysis on, among others, theories on the sportmediacomplex, critique feministic analysis and normative theory.</p><p>       In these articles women are designed into four different stereotypes. We’ve chosen to call them the star, the victim, the sensation and the absent. On the basis on our theories we believe that these four stereotypes are creating more sexism and in that way they are contributing to the suppressing of women as a whole.</p><p>       Our quantitative analysis shows that men occur more frequent on the sport pages than women. Almost nine of ten of the articles in Sportbladet are about men and male athletes. We believe that in this way Sportbladet contributes to the invisibilisation of female athletes and further more to the discrimination of women.</p>
118

Quantitative analysis of multi-phase systems -steels with mixture of ferrite and austenite

Fawad, Salman Kohar January 2004 (has links)
The goal of this work has been to evaluate the different experimental techniques used for quantitative analysis of multi-phase materials systems. Powder based specimens containing two-phases, austenite and ferrite , were fabricated and quantified. The volume fraction of ferrite varied from 2 Vol% to 50 Vol%. X ray powder diffraction (XRD) measurements were based on two peak analysis. Computer based software Topas was used for quantitative analysis, which is believed to be the most advanced in this field. XRD results were found within the absolute limit of +/- 4% of given ferrite volume fraction. Volume fraction as low as 2 Vol% was successfully detected and quantified using XRD. However, high statistical error was observed in case of low volume fraction, such as 2 Vol% and 5 Vol% ferrite volume fraction. Magnetic balance (MB) measurements were performed to determine the volume fraction of magnetic phase, ferrite. MB results were found in good agreement with given volume fractions. As low as 2 Vol% volume fraction was detected and quantified with MB. MB results were within the absolute limit of +/- 4% of given ferrite volume fraction. Image analysis (IA) was performed after proper sample preparation as required by electron backscatter diffraction (EBSD) mode of Scanning electron microscopy (SEM). IM results were found within the absolute limit of +/- 2 % of given ferrite volume fraction. However, high statistical error was observed in case of 2 Vol% volume fraction.
119

Is opacity-induced minor metal market volatility a threat to promising green technologies? : A study of the tellurium market

Söderqvist, Fredrik January 2013 (has links)
Tellurium is one of the rarest metals in the earth’s crust. Increased demand for cadmium telluride photovoltaic cells along with an opaque pricing and quantity-reporting system, have recently caused high price volatility and a speculative bubble in the tellurium market, resulting in overstocking and depressed prices. In a longer perspective this may be a threat to cadmium telluride photovoltaics as a power-generating technology. This master thesis compares how actors may perceive news innovation in the opaque tellurium market compared to the more transparent molybdenum market. A quantitative analysis of industry news reporting on the two metals, combined with a SVAR impulse response analysis, helps me determine which actors and factors exert most influence on spot market prices. In the opaque tellurium market, relatively unreliable proxies of supply and demand are most frequent in the news reporting while having a big impact on prices, whereas the transparent molybdenum market uses more reliable variables – such as futures prices – and transparent supply information, whilst also relying on a frequent stream of dependable proxies to scope market sentiments. My findings lead me to recommend policy makers to implement measures to increase market transparency, which may be accomplished by extending the data-sharing regime of the REACH database to minor metal markets. Attempting to limit speculation in minor metal markets is perhaps too blunt a tool to fix an inherent problem of a free exchange-pricing mechanism. / Tellur är en av de mest sällsynta metallerna på Jorden. Ökad efterfrågan av kadmiumtelluridsolpaneler har nyligen orsakat stor volatilitet på tellurmarknaden. Ett opakt prissättnings-och kvantitetsrapporteringssystem har bidragit till att en prisbubbla bildats och spruckit, vilket resulterat i att marknadsaktörer köpt på sig stora lager till höga priser som de sedan inte kunnat sälja vidare. I ett längre perspektiv kan detta innebära begränsningar vid tillverkning av solcellsteknologi baserad på kadmiumtellurid, då ett volatilt pris kan göra nya tellurgruvprojekt alltför riskabla. Denna masteruppsats jämför hur en typisk marknadsaktör kan reagera på prisinnovationer i den opaka tellurmarkanden och den mer transparenta molybdenmarknaden. Metoden består av en kvantitativ analys av facknyheter rörande de två metallerna, varifrån variabler väljs till en SVAR modell med impuls-responsanalys. Urvalet av variabler är få och volatila på den opaka tellurmarknaden, medan den mer transparenta molybdenmarknaden har ett större utbud av variabler som kännetecknas av god transparens och relativ förutsägbarhet. Mina slutsatser leder mig till att rekommendera beslutsfattare att vidta åtgärder för att öka tellurmarknadens transparens genom EU-samarbetet, förslagsvis genom att göra anonymiserad data från REACH databasen tillgänglig för allmänheten. Samtidigt avråder jag från åtgärder som syftar till att minska spekulation, då implementering av en sådan policy kan bli både dyr och komplicerad.
120

Quantitative analysis of cellular networks: cell cycle entry

Lee, Tae J. January 2010 (has links)
<p>Cellular dynamics arise from intricate interactions among diverse components, such as metabolites, RNAs, and proteins. An in-depth understanding of these interactions requires an integrated approach to the investigation of biological systems. This task can benefit from a combination of mathematical modeling and experimental validations, which is becoming increasingly indispensable for basic and applied biological research. </p> <p>Utilizing a combination of modeling and experimentation, we investigate mammalian cell cycle entry. We begin our investigation by making predictions with a mathematical model, which is constructed based on the current knowledge of biology. To test these predictions, we develop experimental platforms for validations, which in turn can be used to further refine the model. Such iteration of model predictions and experimental validations has allowed us to gain an in-depth understanding of the cell cycle entry dynamics. </p> <p>In this dissertation, we have focused on the Myc-Rb-E2F signaling pathway and its associated pathways, dysregulation of which is associated with virtually all cancers. Our analyses of these signaling pathways provide insights into three questions in biology: 1) regulation of the restriction point (R-point) in cell cycle entry, 2) regulation of the temporal dynamics in cell cycle entry, and 3) post-translational regulation of Myc by its upstream signaling pathways. The well-studied pathways can serve as a foundation for perturbations and tight control of cell cycle entry dynamics, which may be useful in developing cancer therapeutics. </p> <p>We conclude by demonstrating how a combination of mathematical modeling and experimental validations provide mechanistic insights into the regulatory networks in cell cycle entry.</p> / Dissertation

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