L'objectif de cette thèse est de développer des techniques de modélisation et de simulation multi-échelle avancées et efficaces pour étudier les phénomènes d'instabilité dans trois structures d'ingénierie courantes: membrane, film/substrat et structures sandwich, en combinant la technique des coefficients de Fourier lentement variables (TSVFC) et la méthode numérique asymptotique (ANM). À cette fin, basée sur les équations de la plaque de Von Karman, la TSVFC été utilisée pour développer un modèle de Fourier à bidimensionnel (2D) qui a également été implémenté dans ABAQUS via sa sous-routine UEL. Ensuite, un 2D modèle de Fourier est construit pour le film/substrat. En outre, en utilisant leurs caractéristiques de déformation, un 1D modèle de Fourier est développé en utilisant à la fois le TSVFC et le CUF. Par la suite, sur la base d'une cinématique Zig-Zag d'ordre supérieur, un 2D modèle de Fourier est déduit pour une plaque sandwich. Les équations directrices pour les modèles ci-dessus sont discrétisées par la méthode des éléments finis, et les systèmes non linéaires résultants sont résolus par le solveur non linéaire efficace et robuste ANM. Ces modèles sont ensuite adoptés pour étudier les instabilités dans ces structures. Les résultats montrent que les modèles établis peuvent simuler avec précision et efficacité divers phénomènes d'instabilité. En outre, on constate que l'instabilité membranaire est sensible aux conditions aux limites et qu'il existe un paramètre sans dimension presque constant près du point de bifurcation pour différents cas de charge et paramètres géométriques, ce qui peut être utile pour prédire rapidement l'apparition des rides / The main aim of this thesis is to develop advanced and efficient multi-scale modeling and simulation techniques to study instability phenomena in three common engineering structures, i.e., membrane, film/substrate and sandwich structures, by combining the Technique of Slowly Variable Fourier Coefficients (TSVFC) and the Asymptotic Numerical Method (ANM). Towards this end, based on the Von Karman plate equations, the TSVFC has been firstly used to develop a two-dimensional (2D) Fourier double-scale model for membrane, which has also been implemented into ABAQUS via its subroutine UEL. Then a 2D Fourier model is constructed for film/substrate. Further, making use of deformation features of the film/substrate, a 1D Fourier model is developed by using both the TSVFC and the Carrera’s Unified Formulation (CUF). Subsequently, based on high-order kinematics belonging to Zig-Zag theory, a 2D Fourier model is deduced for sandwich plate. The governing equations for the above models are discretized by the Finite Element Method, and the resulting nonlinear systems are solved by the efficient and robust nonlinear solver ANM. These models are then adopted to study instabilities in these structures. Results show that the established models could accurately and efficiently simulate various instability phenomena. Besides, it’s found that the membrane instability is very sensitive to boundary conditions, and there exists a dimensionless parameter that is almost constant near bifurcation point for various loading cases and geometric parameters, which may be helpful for fast predicting the occurrence of wrinkles

La conception sur-mesure de matériaux architecturés à l'échelle du milli/centimètre est une stratégie pour développer des matériaux de structure plus performants vis-à-vis de cahiers des charges multifonctionels. Ce travail de thèse s'intéresse en particulier à la conception optimale de panneaux architecturés périodiques, dans le but de combiner des exigences mécaniques de flexion et de cisaillement, ainsi que de conductivité thermique. Le comportement élastique peut être prédit grâce à l'identification sur la cellule périodique des coefficients de la matrice des souplesses équivalente. Ces calculs d'homogénéisation ont été mis en oeuvre par éléments finis pour estimer en particulier les souplesses en flexion et en cisaillement transverse. Après validation expérimentale, cette méthode de calcul constitue un outil d'évaluation des performances mécaniques pour chaque géométrie de cellule périodique (2D ou 3D). À titre d'exemple, et dans un contexte de développement de solutions matériaux architecturés pour l'automobile, la conception de tôles "texturées" est proposée en menant une étude paramétrique à l'aide de cet outil. L'implémentation d'un algorithme d'optimisation topologique couplé à la procédure d'homogénéisation permet d'enrichir les méthodes de conception sur-mesure en élargissant l'espace de recherche des "architectures". Après l'étude modèle du compromis entre flexion et cisaillement, le cas industriel d'un panneau sandwich isolant est traité. Dans ce cas, l'optimisation fournit plusieurs compromis prometteurs entre rigidité en cisaillement et isolation thermique. Ces géométries ont été réalisées et testées, et une nouvelle version améliorée du panneau sandwich a été sélectionnée. / The "material by design" strategy consists in tailoring architectured materials in order to fulfill multi-functional specifications. This PhD study focuses more specifically on designing architectured panels in regards with mechanical compliances (bending and transverse shear), as well as thermal conductivity. Recent advances on periodic homogenization of plates are integrated into a finite elements tool that enables to identify the Reissner-Mindlin effective compliance from the unit cell geometry. The comparison with four-point bending tests illustrates a discussion on the shear loading for homogenization, and its contribution to the global bending stiffness. In a context of architectured steel solutions for automotive, a parametric study is treated on "embossed" steel sheets using this homogenization tool. As a try to enlarge the space of available "architectures", a topological optimization algorithm (using the level-set method) is coupled to the homogenization procedure. The influence of each parameters of the method are studied on the optimization problem of compromising flexural and shear compliances. Finally, the industrial case of an insulation sandwich panel is treated. Few optimized geometries, with a high combination of shear stiffness and thermal insulation, are built, produced and tested. An improved design is highlighted and proposed as next version of this product.

Une étude détaillée a été effectuée sur des composés organométalliques de carbènes N-hétérocycliques (NHC) de nickel(II), et plus particulièrement sur des complexes demi-sandwich nickel(II)−NHC. Ces complexes ont montré des activités sans précédent en catalyse homogène, notamment en α-arylation de cétones acycliques, où des charges en pré-catalyseur de seulement 1 mol% ont pu être utilisées. L' étude mécanistique de cette réaction tend à montrer l'implication d'intermédiaires radicalaires. De plus, ces complexes demi-sandwich se sont révélés être des pré-catalyseurs performants en hydrosilylation de dérivés carbonylés et d'imines. Les méthodologies qui en découlent fournissent de façon efficace et sélective les produits de réduction correspondants, dans des conditions réactionnelles douces. Un intermédiaire réactionnel demi-sandwich de type nickel−hydrure, agissant probablement comme le véritable précurseur catalytique, a en outre pu être isolé. D'autre part, la synthèse de nouveaux complexes Ni−NHC a remarquablement mené à une nouvelle méthodologie de substitution du ligand cyclopentadienyl dans des dérivés demi-sandwich alkyl,NHC−Ni. Enfin, l'utilisation de NHCs moins classiques, comme les NHCs possédant un squelette malonate, ou encore les carbènes (alkyl)(amine) cycliques, a mené à l'isolement de nouveaux complexes carbéniques de nickel(II), dont les premiers résultats catalytiques sont encourageants. / A detailed study has been conducted on organometallic compounds of N-heterocyclic carbenes (NHC) of nickel(II), in particular on half-sandwich nickel(II)−NHC complexes. These complexes showed unprecedented catalytic activity in homogeneous catalysis, especially in the α-arylation of acyclic ketones, where catalyst loadings as low as 1 mol% could be used. Mechanistic experiments suggest that radicals are implied. Furthermore, these half-sandwich complexes proved to be efficient pre-catalysts in the hydrosilylation of carbonyl compounds and imines, allowing the reduction processes to proceed under mild reaction conditions. During the course of these studies, a half-sandwich nickel−hydride intermediate that probably acts as the true pre-catalyst was isolated. Remarkably, the synthesis of new Ni−NHC complexes led to a methodology for cyclopentadienyl ligand substitution in stable 18-electron alkyl,NHC−Ni derivatives. Finally, the use of less common NHC ligands, such as NHCs possessing a malonate backbone, or else, the use of cyclic (alkyl)(amino) carbenes, led to the isolation of new nickel−carbene complexes, which gave encouraging preliminary catalytic results.

Disertační práce začíná rešerší výpočtů pro návrh sendvičových nosníků, desek a složitějších konstrukcí, kde zaujímá významnou roli MKP. Dále jsou popsány optimalizační metody pro ujasnění široké oblasti matematického programování a základních principů topologické optimalizace až po její implementaci na kompozitní konstrukce jinými autory. Pro názornost jsou zmíněny jak analytické, tak i numerické přístupy k optimalizaci sendvičů, kde numerické přístupy umožňují řešit daleko širší oblast úkolů. Cíl disertační práce je stanoven jako implementace zautomatizovaného algoritmu pro optimalizaci za účelem vylepšení návrhového procesu sendvičů s ohledem na napjatost a únosnost. Cíle je dosaženo prostřednictvím vlastní implementace gradientní optimalizace založené na principech topologické optimalizace, známé jako diskrétní optimalizace materiálu (Discrete Material Optimization - DMO) a jejích variant, které pomáhají najít optimální vrstvení. Přístup k materiálové interpolaci a interpolaci poruchový omezujících podmínek je vyvinut a naprogramován v pythonu za použití teorie smykových deformací prvního řádu (First Order Shear Deformation Theory - FSDT) pro vyhodnocení napětí na elementech na základě zatížení daného MKP řešičem Nastran. Gradientní optimalizér hledá nejlepší materiály pro každou vrstvu potahu sendviče a jádra z definovaných kandidátů. Program je odzkoušený na příkladech různé složitosti od nosníku tvořeného jedním elementem, kde je skutečné optimum známé, až po praktickou úlohu sendvičové kuchyňky z dopravního letadla. Výsledky ukázaly, že algoritmus je schopen dosáhnout diskrétního řešení bez (významného) narušení omezujících podmínek a může tedy být prakticky využit ke zefektivnění koncepčního návrhu sendvičů.

Introduction: There is a housing shortage in Sweden and the green space factor must be taken into account when building. The green space factor includes living façades that have a positive effect on people and society. The company Butong, in which the work has been done in collaboration, has patented solutions within living façades. The company currently mounts the façade solutions on a prefabricated concrete sandwich wall, but lacks a solution for mounting on a half sandwich wall. The purpose of a solution with a half sandwich wall was to avoid unnecessary material consumption, reduce environmental impact, and reduce the thickness of the wall. The work examined a half sandwich wall with three insulation materials: cellular plastic, PIR and Kooltherm. Method: The chosen method for the study was design research methodology, which contains a total of seven steps. The first two steps were used in this study. The first step consisted of a literature study. The second step was supplemented with empirical data in form of interviews and further literature studies. Calculations for carbon dioxide equivalents were performed by calculating the footprint of each material. The calculations were based on the material thickness of 1 m2 wall area. Data were obtained from environmental product declarations for construction products (EPDs) based on factors A1-A3.   Results and Analysis: For all half sandwich walls, a roofboard in stone wool was chosen as the utmost layer. This was based on conditions for fire safety for the materials cellular plastic and PIR, and based on attachment for the material Kooltherm. The use of a polypropylene plastic mat to obtain an air gap was decided for all materials based on moisture safety. Furthermore, the results showed three possible fastening methods for mounting Butong's façade solution on a half-sandwich walls: cast plastic profiles (SFS-profiles), vertically cast L-profiles and horizontally cast L-profiles. The result also reported that replacing a full sandwich wall with a half sandwich wall reduces material consumption, and reduces emissions of carbon dioxide equivalents by up to 31%. This is based on the EPD factors A1-A3 where a comparison of the half sandwich wall was made with a full sandwich wall.  Discussion: The thickness of the walls could be reduced by 60-80 mm when a full sandwich wall was replaced with a half sandwich wall. The variation depended on insulation material. The insulation material Kooltherm resulted in the thinnest wall. The material PIR varied in fire classification. The reason was discussed to be the difference in supply of products in different countries. The choice of attachment method was reported to be dependent on the situation. Cellulose showed the lowest emissions of carbon dioxide equivalents. Both with regard to the production phase, and with regard to the percentage reduction when comparing full sandwich walls and half sandwich walls. In conclusion, the choice of insulation material depends on individual preferences. Cellular plastic should be used when prioritizing at least emissions of carbon dioxide equivalents. Kooltherm is suitable when prioritizing the degree of utilization, considering that the wall is thinnest. / Introduktion och syfte: Det är bostadsbrist i Sverige och det måste tas hänsyn till grönytefaktorn vid bebyggelse. I grönytefaktorn ingår levande fasader som påverkar människor samt samhälle positivt. Företaget Butong, som arbetet har skett i samarbete med, har patenterade lösningar för levande fasader. Företaget monterar idag fasadlösningarna på ett helsandwichelement, men saknar lösning för att montera på ett halvsandwichelement. Syftet med halvsandwichelement var att undvika onödig materialåtgång, minska miljöpåverkan, samt erhålla en tunnare tjocklek på elementet. Arbetet undersökte ett halvsandwichelement utifrån tre ingående isoleringsmaterial: cellplast, PIR och Kooltherm. Metod: Vald metod för arbetet var design research methodology som totalt innehåller sju steg. De två första stegen användes i studien. Första steget bestod av en litteraturstudie. Det andra steget kompletterades med hjälp av empiri i form av intervjuer och fortsatta litteraturstudier. Beräkningar för koldioxidekvivalenter utfördes genom att beräkna respektive materials avtryck. Beräkningarna utgick från materialets tjocklek på 1 m2 väggyta. Data hämtades från miljövarudeklarationer för byggprodukter (EPD:er) utifrån faktorerna A1-A3. Resultat och Analys: För samtliga halvsandwichelement valdes en takboard av stenull som yttersta skikt. Detta utifrån brandsäkerhet för materialen cellplast och PIR respektive utifrån infästning för materialet Kooltherm. Användning av platonmatta för att erhålla en luftspalt bestämdes för samtliga material utifrån fuktsäkerhet. Vidare visade resultatet tre möjliga infästningsmetoder för att montera Butongs fasadlösning på ett halvsandwichelement: ingjutna plastprofiler (SFS-fästen), vertikalt ingjutna L-profiler samt horisontellt ingjutna L-profiler. Resultatet redovisade även att ersätta helsandwichelement med halvsandwichelementet minskar materialåtgång, samt minskar utsläpp av koldioxidekvivalenter med upp till 31%. Detta utifrån EPD-faktorerna A1-A3 där en jämförelse av halvsandwichelementet gjordes med ett helsandwichelement utifrån samma funktionsvärde.  Diskussion: Tjockleken på elementen kunde minskas med 60-80 mm med den nya lösningen. Variationen var beroende av isoleringsmaterial. Isoleringsmaterialet Kooltherm resulterade i tunnast element. Materialet PIR varierade i brandklassning. Anledningen diskuterades vara skillnaden i utbud av produkter i olika länder. Val av infästningsmetod redovisades vara beroende av situation. Cellplast visade lägst utsläpp av koldioxidekvivalenter. Både avseende produktionsfasen, samt med hänsyn till procentuell minskning vid jämförelse av helsandwichelement och halvsandwichelement. Avslutningsvis kunde slutsatsen konstateras att val av isoleringsmaterial beror på individuella preferenser. Cellplast bör användas vid prioritering inom minst utsläpp av koldioxidekvivalenter. Respektive Kooltherm är lämpligt vid prioritering av utnyttjandegrad, då elementet är tunnast.

Edgewise crushing responses of composite aluminum honeycomb sandwich structures were predicted using finite element analysis (FEA) software LS-DYNA by modeling the honeycomb as a material with anisotropic properties. The goal of the project was to develop a process for modeling the sandwich structure to rapidly iterate possible solutions for a safer workstation train table. Current workstation tables are too rigid and may cause injury or death in a head-on collision. Experimental compression tests were used to calibrate the aluminum honeycomb core with material type 26 (MAT 26, honeycomb). A published composite tensile test was used to validate the use of material type 22 (MAT 22, composite damage) for laminates. Finally, a model was made to recreate the results of a published compression test of an aluminum honeycomb sandwich structure with aluminum sheet metal face sheets to confirm contact types. With each component of the model verified separately, three plain weave composite aluminum honeycomb sandwich structures were modeled, one with [0/90] composite sheets completely bonded to the core, one with [0/90] composite sheets partially bonded to the core, and one with [±45] composite sheets partially bonded to the core. The failure modes for each sandwich structure were previously shown through research and the elastic region of the response was checked for accuracy using a simple beam theory. The analysis suggests that incorporating unbonded zones into the sandwich structure will change the failure mode from general buckling to face wrinkling, which effectively lowers the failure strength while not sacrificing energy absorption throughout loading. The analysis also indicates that using an angled ply orientation will lower the initial stiffness and the failure load. Future work is recommended such as performing compression tests with composite aluminum honeycomb sandwich structures and integrating delamination failure modes into the model using cohesive elements.

As the aging population is increasing worldwide, so is the prevalence of neurodegenerativediseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD), frontotemporal dementia(FTD) and amyotrophic lateral sclerosis (ALS). Reliable biomarkers able to aid the diagnosis anddifferentiation of these diseases are needed in order to start the right treatment as early as possible.Due to its representative state of the central nervous system, cerebrospinal fluid (CSF) is afavorable sample material for biomarker discovery within neurodegenerative diseases. Alteredprotein levels of this body fluid might serve as a biomarker, but further validation of earlierfindings is needed. The aim of this project was to validate earlier studies suggesting potentialprotein biomarkers in CSF. From a list of 80 potential biomarkers in the CSF of patient samples,eight were chosen to be included in this validation effort. By utilizing a suspension bead array ina sandwich assay setup, 21 antibodies were tested in an initial screening. Antibody pairs that couldmeasure the protein levels in a dilution dependent manner was further optimized before individualpatient samples were analyzed. Sandwich assays targeting the three proteins Amphiphysin(AMPH), Chitotriosidase-1 (CHIT1) and Beta-synuclein (SNCB) were successfully developed andcorrelated to earlier generated data using a suspension bead array with a single binder setup.Therefore, the earlier findings of elevated levels of AMPH and SNCB in AD patients and CHIT1in ALS patients were successfully validated. / Prevalensen av neurodegenerativa sjukdomar såsom Alzheimers sjukdom (AD), Parkinsonssjukdom (PD), frontallobsdemens (FTD) och amyotrofisk lateralskleros (ALS) ökar i takt med denåldrande populationen. Pålitliga biomarkörer som kan hjälpa till vid diagnostiseringen av dessasjukdomar behövs för att starta rätt behandling så tidigt som möjligt. Ryggmärgsvätska, enkroppsvätska tillhörande det centrala nervsystemet, kan ge en inblick i det centrala nervsystemetstillstånd. Förändrade proteinnivåer i denna kroppsvätska skulle därför kunna fungera sombiomarkörer. Målet i detta projekt var att validera tidigare föreslagna proteinbiomarkörer iryggmärgsvätska. Utifrån en lista av 80 tidigare analyserade proteiner i ryggmärgsvätska hospatienter, inkluderades åtta proteiner i detta valideringsförsök. En antikroppsbaserad så kalladsandwich assay användes i en suspension bead array för att testa 21 stycken antikroppar i ett initialtscreeningsförsök. Antikroppspar som kunde mäta proteinnivåer på ett spädningsberoende vis i detinitiala screeningsförsöket optimerades vidare innan den utvecklade sandwich assayn användes föratt analysera proteinnivåer i individuella prover. Sandwich assays gentemot Amphiphysin(AMPH), Chitotriosidase-1 (CHIT1) och Beta-synuclein (SNCB) kunde bli framtagna ochkorrelerade gentemot tidigare genererat data från en single binder assay på ett framgångsrikt sätt.Projektet kunde därmed validera tidigare fynd som indikerat förhöjda nivåer av AMPH och SNCBi AD patienter, samt förhöjda nivåer av CHIT1 i ALS patienter.

This thesis helps develop a material model for a novel Fiber Core SandwichSheet construction. A test method was used to determine the mechanicalproperties of the sandwich material. Standard three point bendingtests coupled with digital image correlation was used. Results wereextracted from the digital image data. These results supplemented thedevelopment and tuning of an FE model of the sandwich material. Conclusionswere drawn about the feasibility of the method in studying sucha material. / Denna avhandling genomfördes mot utvecklingen av en homogeniseradmaterialmodell för en ny sandwich-konstruktion med fiberkärna. En testmetodanvändes för att bestämma de mekaniska egenskaperna hos sandwichmaterialet.Testmetoden involverade trepunkts i kombination meddigital bildkorrelation. Resultaten extraherades från den digitala bilddatanvid genomförande av trepunkts. Dessa resultat användes utvecklingenav en FE-modell av sandwichmaterialet. Slutsatser drogs om tillämplighetenav metoden för att studera ett sådant material.

Betondecken sind materialintensive Biegetragwerke, wenn sie, wie derzeit üblich, eben und aus einer Betonsorte hergestellt werden. Die Materialien sind dadurch nur an wenigen Stellen maximal und effizient ausgenutzt. Die vorliegende Dissertation greift ein daraus resultierendes Optimierungspotential auf. Eine verbesserte Ausnutzung der Baustoffe Beton und Stahl gelingt durch einen dreischichtigen Querschnittsaufbau. Dabei nehmen die beiden äußeren Betonschichten mit der eingebrachten Stahlbewehrung vor allem die Beanspruchungen aus Biegung und die Kernschicht aus Schub auf. Als Kernschichtmaterial kommen dabei Leichtbetone zur Anwendung. Der Fokus liegt auf der Untersuchung von schlaff bewehrten, einachsig gespannten, einfeldrigen Flachdecken des gewöhnlichen Wohnungs- und Bürobaus. In der Arbeit wird ein Überblick über den aktuellen Entwicklungsstand und die bereits vorliegenden Forschungsarbeiten zu geschichteten, sandwichartigen Betondecken gegeben. Sie geht auf die Eigenschaften von Beton, Stahl und Stahlbeton und ausführlich auf den Verbund zwischen Betonschichten ein, der die Tragfähigkeit geschichteter Betondecken besonders beeinflusst. Anschließend werden verschiedene Bauteilzustände erläutert und die Versagensarten, die bei geschichteten Elementen auftreten können, vorgestellt. Dazu gehören maßgeblich das Biegezug- und Biegedruckversagen sowie das Biegeschub- und Fugenversagen. Es werden sowohl Formeln zur Berechnung von Durchbiegungen im Gebrauchszustand als auch von Bruchlasten in Abhängigkeit der Versagensart bereitgestellt. Auch sind Rechenansätze zur Beurteilung des Bauteilzustandes infolge des unterschiedlichen Schwindens der Betone aufgeführt.

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