Thesis (Ph. D.)--Ohio State University, 2006. / Title from first page of PDF file. Includes bibliographical references (p. 209-217).

O diagnóstico precoce e o tratamento são imprescindíveis para o controle da hanseníase, pois visam eliminar o mais precocemente possível as fontes de transmissão. O principal critério de cura da doença é o tempo de tratamento, relacionado às doses fixas da poliquimioterapia. O tempo de tratamento dos pacientes multibacilares foi reduzido de 24 para 12 doses em até 18 meses em 1998. Os objetivos desta tese foram: avaliar a detecção de casos de hanseníase entre os contatos dos pacientes e avaliar fatores de risco associados à piora das incapacidades físicas nos pacientes após a alta do tratamento poliquimioterápico com as 12 doses mensais. Dois artigos foram elaborados. O primeiro artigo avaliou características dos pacientes com hanseníase e de seus contatos associadas ao risco de adoecimento entre os contatos. O segundo artigo avaliou fatores de risco relacionados à piora das incapacidades físicas dos pacientes com hanseníase multibacilar, submetidos ao tratamento com 12 doses fixas da poliquimioterapia. Os resultados mostraram que o risco para hanseníase, relacionado aos contatos foi o tipo de convivência com o caso índice. Entre os fatores dos casos índices, a carga bacilar foi o único associado ao adoecimento dos contatos. Além desses fatores, os contatos que apresentam relação de consangüinidade com o caso índice e os contatos dos pacientes com menor nível de escolaridade mostraram maior chance de se apresentarem doentes no momento do diagnóstico do caso índice. A cicatriz BGC e a vacina recebida após o diagnóstico do caso índice contribuíram independentemente como fatores de proteção. A neuropatia piorou em 40% dos pacientes durante o período de 10 anos após a alta do tratamento. Esta piora foi associada à presença de incapacidades físicas e ao número de lesões cutâneas no momento do diagnóstico assim como à presença de neurite durante o acompanhamento. / Early diagnosis and treatment are essential for the control of leprosy disease, since they aim to eliminate as soon as possible sources of transmission. The main criterion for cure of the disease is the treatment time, related to fixed doses of multidrug therapy. The duration of treatment of multibacillary patients was reduced from 24 to 12 doses up to 18 months in 1998. The aim of this thesis is to evaluate the detection of leprosy among contacts of patients and to evaluate risk factors associated with worsening of physical disability in patients after discharge from the treatment with 12 monthly doses. Two articles have been prepared. The first article evaluated characteristics of leprosy patients and their contacts related to risk of disease among the contacts. The second article evaluated risk factors related to the worsening of the physical disabilities of patients with multibacillary leprosy, undergoing treatment with fixed doses of 12 multidrug therapy. The results showed that the risk for leprosy among contacts was related to the type of relationship with the index case. Among the factors of the index cases, the bacterial load was the only factor associated with the disease among contacts. Besides these factors, the contacts that are related to consanguinity with the index case and contacts of patients with lower education level showed a greater chance of presenting patients at diagnosis of the index case. The scar and the BGC vaccine received after the diagnosis of the index case contributed independently as protective factors. Neuropathy worsened in 40% of patients during the 10 years after the discharge of treatment. This worsening was associated with the presence of physical disabilities and number of lesions at time of diagnosis as well as the presence of neuritis during monitoring.

Taking as its subject the Russo-Ottoman borderland during the period between the Treaty of Berlin (1878) and the start of the First World War (1914), and making extensive use of Ottoman archival documents covering this period, this thesis focuses on the ways in which the Ottoman state attempted to establish two types of boundary in order to ensure sovereignty over its territory. Firstly, there was a new geo-political border, the line dividing the Russian and Ottoman Empires at the juncture of north-eastern Anatolia and the southern Caucasus, created by the Treaty of Berlin. Secondly, there was what can be called a citizenship boundary, shaped by various laws and regulations defining the Ottoman citizenry. The main issues examined in respect of the first boundary are various types of human movement across this border and their control by the Ottoman state. Primary concerns regarding the second boundary revolve around the inclusion in and exclusion from the Ottoman citizenship of ethno-religious groups as a result of the Ottoman state's enforcement of the border. Our approach to studying how the citizenship boundary was established is two-fold, reflecting both local and state perspectives. The local perspective shows the actions of the inhabitants and travellers passing through this border region as shaped by their own day-to-day needs, livelihood patterns and pre-existing socio-economic relations; these resisted limitation by the logic of the sovereign state. The state perspective reflects the Ottoman view of Russia as the main threat to its border territories; this view led the Ottoman central authorities to perceive the entanglements and overlapping positions of its subjects in and with Russia as the cause of their ambiguous loyalties to the Ottoman state. In focusing on the specific policies and practices that the Ottoman state applied in order to deal with this ambiguity, two groups of people, Muslims and Armenians, are singled out. Notwithstanding the all-embracing state laws and discourse of legal equality, Ottoman border policy in respect of its Muslim subjects is shown to have differed greatly from that designed for its Armenian subjects. Therefore, the thesis offers a nuanced framework with which to understand Ottoman citizenship in the Russo-Ottoman border context, by revealing the normative and practical measures the Ottoman state employed to classify its Muslim and Armenian populations, thereby differentiating their status as subjects. This thesis - the first English-language work on the Russo-Ottoman border region during the late nineteenth century and pre-WWI period- offers a range of original insights into this borderland in particular and related issues more generally. It unfolds the details of everyday life and represents the local people as active agents - active, moreover, in relation both to the changing nature and effectiveness of the state's assertion of territorial authority and also to the differences between the two empires' policies and practices. Overall, the thesis focuses on the end-of-empire border politics and the issue of Ottoman citizenship not only from the perspective of macro-level political developments and central state power but also in terms of the peripheral specificities of administration and the movements and subjecthood choices of villagers. Thus, this thesis presents a new type of multi-faceted account of borderland development in which ethno-religious considerations came to inform a somewhat messy production of sovereignty in the context of the modernizing transition between empire and nation-state.

Dans cette thèse, nous proposons une mise en lumière des aspects linguistiques relatifs aux phénomènes de contacts entre locuteurs arabophones et locuteurs appartenant à la communauté sicilienne de Tunisie à travers l’étude d’une chronique particulière, éditée dans le journal italien Simpaticuni (1911-1933). L’un des objectifs de cette recherche est l’analyse du tissu linguistique du corpus dans le but de déterminer la nature véritable de cette langue. Cela se traduit par l’identification des particularités phono-graphiques, morphologiques, syntaxiques et lexicologiques de la langue employée, et par la recherche de la sicilianité des textes en déterminant le degré de dialectalité. Puis, nous examinons les mots empruntés à l’arabe tunisien afin d’en analyser le fonctionnement et la modalité d’insertion dans le tissu syntaxique des chroniques et d’en définir la typologie. S’agit-il de référents à des objets quotidiens ? D’insertions pragmatiques? Quelle est la signification de ces choix ? Enfin, étant donné la nature dialogale de nos textes, nous étudions les variétés en interaction, travail qui permettra d’interpréter la présence des emprunts à l’arabe dans le discours. La numérisation exhaustive d’une rubrique particulière du Simpaticuni a pour objectif d’élargir la quête lexicologique des auteurs qui ont travaillé sur ce journal. / In this thesis, we propose to highlight the linguistic aspects relating to languages in contact, more particularly between Arabic and Sicilian speakers of Tunisia, through the study of a particular column, published in the Italian newspaper Simpaticuni (1911-1933). One of the issues of this research is to analyses the linguistic base of the corpus, aiming at determining the real nature of this language. In this respect we describe the phonographic, morphological, syntactical and vocabulary features of this language, and measure in what extent the given texts are of a Sicilian nature according to their dialectal degree. We then gather the words borrowed from Tunisian Arabic in order to study their function and the way they occur inside the syntactic structure of the columns, and therefore define their typology. Would they refer to daily objects? Or to pragmatic inclusions? What do these choices mean? Finally, given the speech nature of our texts, we study the varieties in interaction, which will enable us to understand why some words have been borrowed from Arabic. Digitising the whole particular column of the Simpaticuni will enhance the glossary collection undertaken by other scholars who previously worked on this newspaper.

L’adrénomédulline (AM) est un des principaux facteurs de croissance impliqués dans la formations de nouveaux vaisseaux. L’AM est responsable de la formation de jonctions adhérentes stables entre cellules endothéliales vasculaires via le maintien d’un état déphosphorylé du complexe d’adhésion VE-cadhérine/caténines. La phosphorylation de tyrosines est un évènement régulé par un équilibre entre protéine tyrosine kinases et protéine tyrosine phosphatases (PTP). Peu de choses sont encore connues sur le rôle des PTPs dans les voies de signalisation de l’AM au niveau des cellules endothéliales. La SHP2 a été décrite comme étant capable de déphosphoryler le complexe d’adhésion. Son association avec la β-caténine lui permet de contrôler le niveau de phosphorylation du complexe et de maintenir l’association entre VE-cadhérine et caténines. Nous avons ainsi émis l’hypothèse selon laquelle l’AM puisse agir sur la SHP2 permettant ainsi le contrôle de la formation du complexe d’adhésion VE-cadhérine-β-caténine. Nos travaux ont mis en évidence une augmentation de l’activation de la SHP2 induite par l’AM dans les cellules endothéliales entrainant sa localisation au niveau de la membrane et la stabilisation de l'adhésion cellulaire induite par la VE-cadhérine en réduisant le niveau de phosphorylation de cette dernière. Le blocage de la SHP2 entraine des effets opposés avec une inhibition de la déphosphorylation induite par l’AM de la VE-cadhérine sur les tyrosines 731 et 658. En résumé, l’AM régule l’activité de la SHP2 via sa phosphorylation sur la tyrosine 542 ce qui entraine une stabilisation des contacts cellules-cellules via une diminution de la phosphorylation de la VE-cadhérine. / Adrenomedullin (AM) is one of the main factors in the formation of tumor neo-vessels. It's responsible for stable adherent junction formation between vascular endothelial (VE) cells by maintaining VE-cadherin/catenins adhesion complex in a dephosphorylated status. Indeed, AM blockade induces phosphorylation of VE-cadherin in tyrosine 731, which is followed by disruption of VE-cadherin-mediated cell-cell contacts of endothelial cells (ECs), thereby leading to EC adhesion loss and tumor vessels disruption. Tyrosine phosphorylation events are controlled by the balance of activation of protein tyrosine kinases and protein tyrosine phosphatases (PTPs). Little is known about the role of endogenous PTPs in AM signaling in ECs. SHP2 is capable of dephosphorylating the complex. Its association with β-catenin allows it to control the dephosphorylated steady state of the complex and to maintain the VE-cadherin/β-catenin association. To study the mechanism of AM on the inter-endothelial junction stabilization, we hypothesized that AM may act on SHP2 allowing a control upon formation of VE-cadherin-β-catenin complex. In this study, we found that SHP2 activity is markedly increased by AM. In ECs, AM-induced phospho-SHP2 Y542 activity to localize at the human umbilical vein endothelial cell membrane and stabilizes VE-cadherin-mediated cell-cell adhesions by reducing VE-cadherin tyrosine phosphorylation. SHP2 inhibition causes opposite effects with inhibiting AM-induced dephosphorylation of VE-cadherin at Y731 and Y658. In summary, AM regulates SHP2 activity through phosphorylation of Y542, which stabilizes cell-cell adhesions through reducing tyrosine phosphorylation of VE-cadherin.

Quelle sont les points communs entre un robot humanoïde et un quadrimoteur ? Et bien, pas grand-chose… Cette thèse est donc dédiée au développement d’algorithmes permettant de contrôler un robot de manière dynamique tout en restant générique par rapport au model du robot et à la tâche que l’on cherche à résoudre. Le contrôle optimal numérique est pour cela un bon candidat. Cependant il souffre de plusieurs difficultés comme un nombre important de paramètres à ajuster et des temps de calcul relativement élevés. Ce document présente alors plusieurs améliorations permettant d’atténuer ces difficultés. D’un côté, l’ordonnancement des différentes tâches sous la forme d’une hiérarchie et sa résolution avec un algorithme adapté permet de réduire le nombre de paramètres à ajuster. D’un autre côté, l’utilisation de l’apprentissage automatique afin d’initialiser l’algorithme d’optimisation ou de générer un modèle simplifié du robot permet de fortement diminuer les temps de calcul. / What are the common characteristics of humanoid robots and quadrotors? Well, not many… Therefore, this thesis focuses on the development of algorithms allowing to dynamically control a robot while staying generic with respect to the model of the robot and the task that needs to be solved. Numerical optimal control is good candidate to achieve such objective. However, it suffers from several difficulties such as a high number of parameters to tune and a relatively important computation time. This document presents several ameliorations allowing to reduce these problems. On one hand, the tasks can be ordered according to a hierarchy and solved with an appropriate algorithm to lower the number of parameters to tune. On the other hand, machine learning can be used to initialize the optimization solver or to generate a simplified model of the robot, and therefore can be used to decrease the computation time.

A presente Tese perscruta a influência do contato linguístico entre afrodescendentes, nomeadamente quilombolas, e comunidades de fala presentes em seu entorno em diferentes áreas sócio-geográficas do Rio Grande do Sul (RS). Seu objetivo central é realizar uma macroanálise pluridimensional da variação do português nessas comunidades afro-brasileiras, dando especial atenção aos fenômenos que remontam, de um lado, a uma origem africana ou que, de outro lado, sinalizam uma mudança na direção do português contemporâneo. Este estudo busca contribuir, neste sentido, para integrar os estudos de línguas africanas e de seu contato com a língua portuguesa no Brasil, ampliando o conhecimento da língua falada por afro-brasileiros (PESSOA DE CASTRO, 1990; VOGT; FRY, 1996; CARENO, 1997; PETTER, 2001 e 2002; PETTER; FIORIN, 2009; LUCCHESI, 2009). O RS conta, atualmente, com 155 comunidades afro-brasileiras que englobam 3831 famílias. As comunidades selecionadas para esta Tese foram: RS01 Morro Alto (Osório) - Região do Litoral/Lagunas; RS02 Família Fidelix (Porto Alegre) – Região Metropolitana; RS03 Maçambique (Canguçu) - Região das Antigas Charqueadas; RS04 Palmas (Bagé) – Região dos Pampas; RS05 Cerro Formigueiro (Formigueiro) – Região da Depressão Central; RS06 São Roque (Arroio do Meio) – Serrana/Imigração e RS07 Comunidade Quilombola Correa (Giruá) – Região das Missões. As localidades selecionadas diferenciam-se por uma série de fatores, seja de ordem sócio-histórica, política ou geográfico, que podem influenciar a língua (portuguesa) falada nessas comunidades. Trata-se, em termos dialetológicos, de espaços descontínuos que lembram ilhas linguísticas, ocupadas por determinada população caracterizada por traços como origem étnica e língua particular, em que é possível identificar a comunidade afro-brasileira como um grupo minoritário diferente de outros. Para investigar a variedade do português falado nessas comunidades, nos baseamos na perspectiva teórica da dialetologia pluridimensional, conforme Thun (1998), Radtke e Thun (1996), a qual inclui nas pesquisas linguísticas diferentes dimensões espaciais e sociais em comunidades de fala distintas. Segundo Thun (1998), a “dialetologia pluridimensional” pode ser compreendida como a ciência geral da variação linguística e das relações entre variantes e variedades de um lado e de falantes de outro. À dimensão diatópica ou areal da geolinguística tradicional se incorporam outras dimensões, tais como a idade (dimensão diageracional) e o sexo (dimensão diassexual) etc. Através desse modelo de macroanálise da variação e dos contatos linguísticos, foi possível identificar no comportamento linguístico variável das sete comunidades afro-brasileiras alguns fatores determinantes da variação e mudança do português, apontados pelos dados dos diferentes pontos de pesquisa (dimensão diatópica), grupos etários GII e GI (dimensão diageracional) e falantes homens e mulheres (dimensão diassexual). A cartografia dos dados levantados por meio de um Questionário Fonético-fonológico - QFF (22 mapas) e de um Questionário Semântico-lexical - QSL (54 mapas) permitiu observar e comprovar empiricamente algumas tendências, entre as quais se destacam as seguintes: a) o comportamento linguístico dos membros dessas comunidades com respeito à manutenção ou perda das marcas de africanidade no português varia entre 1) uma variedade mais conservadora, mais presente entre os falantes mais velhos, 2) uma adequação ao português regional ou geral falado no entorno dessas comunidades e, por fim, 3) uma reintegração de marcas de africanidade em virtude de uma consciência étnica e identitária crescente que pode ser associada à própria constituição e reconhecimento dessas comunidades quilombolas; b) na dimensão diageracional, observou-se, portanto, uma mudança em curso geral, em toda a rede de pontos da pesquisa, na direção tanto da perda quanto da reintegração de marcas de africanidade nesses contextos; c) na dimensão diassexual, as mulheres parecem apresentar uma tendência maior de adesão às inovações ou às variantes do português do entorno, já os homens se mostram como os mais conservadores; d) no plano diatópico, o conjunto dos pontos de pesquisa se distingue entre uma adesão maior ou menor a determinadas variantes [+/- afro], sendo que se pode visualizar as seguintes tendências nos mapas: 1) o comportamento linguístico dos afro-brasileiros nos pontos RS01 e RS02 parece refletir uma consciência étnica e identitária maior, provavelmente como reflexo de ações do movimento negro. Estes pontos do litoral e metropolitano são os que mais conhecem formas [+afro]. 2) RS02, RS03 e RS05 como pontos mais próximos de grandes centros urbanos (Porto Alegre, Pelotas e Santa Maria) compartilham, ao mesmo tempo, influências que sugerem uma aproximação ao português brasileiro mais geral. Essa tendência, no entanto, carece de uma descrição mais clara. 3) RS05 (de Depressão Central) e RS07 (das Missões) são os pontos que apresentam mais perdas de marcas [+afro] no português. São, ao mesmo tempo, os pontos mais distantes do litoral. 4) RS06 e RS07 são os pontos que, ao menos na variação fonética, apresentam mais influências do português de contato com línguas de imigração (alemã e italiana). RS07 se destaca, aliás, pela resistência a formas inovadoras do português brasileiro. 5) os pontos mais ao norte – RS01, RS06, RS07 e, em parte, RS05 apresentam variantes que sugerem a influência do português paulista, sobretudo na fonética, provavelmente reflexo do contato linguístico que se deu por meio das rotas de tropeiros, no séc. XIX. 6) RS04, ao contrário, reflete fortemente o português fronteiriço, já entre falantes da GII, o que pode sugerir uma perda, já bem cedo, de marcas [+afro] em favor do português dominante no entorno, falado pelos luso-brasileiros. Esta tendência é compartilhada, em parte, pelo ponto RS03, que no entanto apresenta um comportamento mais variável (não tão estável como na Região dos Pampas) que oscila entre uma influência anterior regional e uma influência recente mais geral do português brasileiro. Em suma, os comportamentos linguísticos dos membros das comunidades afro-brasileiras pesquisadas, no Rio Grande do Sul, convergem de modo geral para uma orientação centrífuga, que se contrapõe à noção de isolamento que tradicionalmente se associa a esse tipo de contexto, visto que a perda de marcas de africanidade e adoção de marcas da variedade do português brasileiro e regional do entorno é uma constante. / This thesis investigates the influence of language contact between African descent, including Quilombolas, and speech communities present in your surroundings at different socio-geographical areas of Rio Grande do Sul (RS). Its main objective is to perform a multidimensional macro analysis of the variation of these african Portuguese-Brazilian communities, with special attention to phenomena that go back on the one hand, an african origin or, on the other hand, indicate a change in the direction of contemporary portuguese. This study seeks to contribute in this sense to integrate the study of african languages and their contact with the portuguese in Brazil, expanding the knowledge of the language spoken by afro-brazilians (CASTRO PERSON, 1990; VOGT; FRY, 1996; CARENO 1997; Petter, 2001 and 2002; Petter; FIORIN, 2009; LUCCHESI, 2009). The RS currently has 155 afro-brazilian communities that include 3831 families. The communities selected for this thesis were: RS01 Morro Alto (Osório) – Litoral/Lagunas Region; RS02 Família Fidelix (Porto Alegre) - Metropolitana Area; RS03 Maçambique (Canguçu) - Region of the Antigas Charqueadas; RS04 Palmas (Bagé) - Region of the Pampas; RS05 Cerro Formigueiro (Formigueiro) - Region of Depressão Central; RS06 São Roque (Arroio do Meio) - Serrana/Imigração and RS07 Comunidade Quilombo Correa (Giruá) - Region of Missões. The selected locations are distinguished by a number of factors, whether socio-historical, political or geographical, that may influence the language (Portuguese) spoken in those communities. Certain population characterized by traits like ethnicity and particular language in dialetologics terms of discontinuous spaces that resemble linguistic islands, occupies it, it is possible to identify the afro-brazilian community as a different minority group of others. To investigate the variety of Portuguese spoken in those communities, we rely on the theoretical perspective of multidimensional dialectology as Thun (1998), Radtke and Thun (1996), which includes the linguistic research different spatial and social dimensions in different speech communities. According Thun (1998), “multidimensional dialectology” can be understood as the general science of language variation and relations between variants and varieties on one side and the other speakers. To diatopical dimension or areal of the traditional geolinguistic incorporate other dimensions, such as age (diageracional dimension) and sex (diassexual dimension) etc. Through this macro analysis model of variation and language contacts, it was possible to identify the variable linguistic behavior of the seven afro-brazilian communities some determinants of variation and change in portuguese, indicated by data from different points of research (diatopical dimension), age groups GII and GI (diageracional dimension) and talking men and women (diassexual dimension). The mapping of data collected through a phonetic-phonological Questionnaire - QFF (22 maps) and a Semantic-lexical Questionnaire - QSL (54 maps) allowed to observe and empirically demonstrate some trends, among which the following stand out: a) the linguistic behavior of members of these communities with respect to the maintenance or loss of Africanity marks in portuguese varies between 1) a more conservative range, more present among older speakers, 2) an adjustment to regional or general portuguese spoken around these communities and, finally, 3) reintegration African identity marks due to a growing ethnic consciousness and identity that can be associated with own constitution and recognition of these quilombolas communities; b) in diageracional dimension, it was observed, so a change in the general course, throughout the network of research points toward both the loss and the reintegration of africanity marks in these contexts; c) in diassexual dimension, women appear to be more likely to join the innovations or of the portuguese surrounding variants, since men are shown as the most conservative; d) in diatopic plan, the research points of the set is distinguished from a greater or lesser adherence to certain variants [+/- afro], and you can view the following trends in maps: 1) the linguistic behavior of afro-brazilian RS01 and RS02 in points seems to reflect a more ethnically and identity awareness, probably as a result of actions of the black movement. These points of the Litoral and Metropolitana are the most known forms [+ afro]. 2) RS02, RS03 and RS05 as closest points of large cities (Porto Alegre, Pelotas and Santa Maria) share at the same time, influences that suggest an approach to the broader brazilian portuguese. This trend, however, lacks a clearer description. 3) RS05 (Depressão Central) and RS07 (Missões) are the points that have more losses brands [+ afro] in portuguese. Are at the same time, the farthest points of the coast. 4) RS06 and RS07 are the points that, at least in phonetic variation, have more influences of portuguese contact with immigration languages (german and italian). RS07 stands out, moreover, by the resistance to innovative forms of brazilian portuguese. 5) points further north - RS01, RS06, RS07 and partly RS05 feature variations that suggest the influence of São Paulo portuguese, especially in phonetics, probably reflecting the language contact that occurred through the drovers routes, in the 19th century. 6) RS04, by contrast, strongly reflects the portuguese border, already among speakers of the GII, which may suggest a loss since early, marks [+ afro] in favor of the portuguese dominant in the surroundings, spoken by the luso-brazilians. This trend is shared in part by the RS03 point, which however has a more variable behavior (not as stable as in the region of the Pampas) dangling from a previous regional influence and a more general influence of recent brazilian portuguese. In short, the linguistic behavior of members of the surveyed afro-brazilian communities in Rio Grande do Sul, converge generally to a centrifugal direction, which goes against the notion of isolation that traditionally associated with this kind of context, as the loss of africanity marks and adoption marks of the variety of brazilian portuguese and surrounding regional brands is a constant.

Ce travail de thèse Cifre, réalisé dans le cadre de la collaboration avec la société Elbi, porte sur la modélisation de la géométrie et de la cinématique du système vis à rouleaux. Ce travail analyse la cinématique et la géométrie du mécanisme de vis à rouleaux satellites (RSM) pour fournir une base fondamentale pour soutenir ses diverses applications. Un modèle 3D du système vis à rouleaux est développé. Un code numérique a été développé en fonction de la géométrie et la cinématique du système de vis à rouleaux. Le champ d’effort et le champ de pression en fonction des défauts de forme et de la géométrie sont obtenus dans ce travail. Ensuite, un modèle 3D du moment de frottement dans le contact entre les surfaces de la vis à rouleaux est développé. La vitesse de glissement et la force de frottement se produisant entre vis/rouleau et entre rouleau/écrou a été calculé conformément à la cinématique, la géométrie et les erreurs de forme. L’efficacité, les pertes par frottement et la durée de vie du mécanisme de la vis à rouleaux en fonction des défauts de forme, de la cinématique et de la géométrie sont obtenues. Ces résultats numériques montrent le rendement important du système de vis à rouleaux en fonction des défauts de forme (autour de 97%). Par ailleurs, une partie expérimentale a été faite sur un banc d’essais électromécanique en collaboration avec le laboratoire Ampère d’Insa de Lyon afin de comparer les résultats expérimentaux avec les résultats théoriques. Ces expériences nous permettent de découvrir plusieurs sources de pertes de frottement dans l’ensemble du banc d’essais, ce qui confirme le faible rendement obtenu expérimentalement (autour de 50 %) pour tout l’ensemble (vérin électromécanique, réducteur). Quelques optimisations ont été effectuées pour améliorer l’efficacité de l’ensemble. Mais il reste difficile de quantifier l’efficacité de système (vis-rouleaux-écrou) expérimentalement. Pour cela, des essais manuels effectués en utilisant le système vis à rouleaux seul confirme les résultats numériques. Une autre partie expérimentale (en utilisant les machines MTM et HFRR) a été faite afin d’obtenir l’influence du lubrifiant sur le coefficient de frottement. Quatre huiles de différentes caractéristiques ont été utilisées. Ces huiles ont été utilisées sur le banc d’essais, mais l’influence du lubrifiant sur le rendement de l’assemblage n’est pas obtenue à cause de la rugosité importante des surfaces de contact du système vis à rouleaux. / This PhD work, carried out in collaboration with the Elbi company concerns the modeling of the geometry and the kinematics of the roller screw system. This work analyzes the ki- VII Résumé nematics and the geometry of the planetary roller screw mechanism (RSM) to provide a fundamental basis to support its various applications. A 3D model of the roller screw system is developed. A numerical code has been developed as a function of the geometry and the kinematics of the roller screw system. The force and the contact pressure distribution as a function of form errors and geometry are obtained in this work. Then, a 3D model of the frictional moment was developed. The sliding speed and the frictional force (between screw/roller and roller/nut) was calculated as a function of the kinematics, the geometry and the form error. Efficiency, frictional losses and the lifetime of the roller screw mechanism as a function of the form errors, the kinematics and geometry are obtained. These numerical results show the high efficiency of the roller screw system (around 97 %). Furthermore, experiments were performed on an electromechanical bench in collaboration with the laboratory Ampére of INSA Lyon, to compare these results with theoretical predictions. These experiments reveal several sources of friction losses, which confirms the low efficiency obtained experimentally (around 50 %) for the complete system (electromechanical actuator and gearbox). Some optimizations have been made to improve the efficiency of the assembly. But it remains difficult to quantify the efficiency of the set (screw-roller-nut) experimentally because of the presence of many sources of friction. To attain this goal, manual tests using the single roller screw system confirm the numerical results. Furthermore, another experimental part (using the HFRR and MTM Machines) was carried out to obtain the influence of the lubricant on the friction coefficient. Four oils of different characteristics were used. These four oils were used on the test bench, but the influence of the lubricant on the performance of the system was not obtained due to the high roughness of the contact surfaces of the roller screw system.

Die vorliegende Untersuchung befasst sich mit der Variation des gesprochenen Deutsch von Nachfahren böhmischer Einwanderer in der Gemeinde von Linha Brasil in Paverama, Rio Grande do Sul, Südbrasilien, auch Eestreich (vgl. Hdt. Österreich) von der lokalen Bevölkerung genannt. Diese Gruppe von Einwanderern siedelte sich um 1873 in der Gegend an, und zwar in einem Gebiet, in dem bereits Hunsrücker sowie auch andere Gruppen angesiedelt waren. Als Böhmer bezeichnet man im Folgenden eine Gruppe deutschsprachiger Einwanderer, die aus der Ausgangsmatrix Böhmen stammt, das heute ein Teil der Tschechischen Republik ist, zum Zeitpunkt der Auswanderung aber zur ehemaligen Österreichisch-Ungarischen Monarchie gehörte (1867-1918). In Brasilien kamen diese Immigranten nicht nur in Kontakt mit dem Portugiesischen, sondern auch mit anderen deutschen Varietäten, besonders mit dem Hunsrückischen in der Nachbarsiedlung Santa Manoela (auf Deutsch auch Russland genannt). Das zentrale Ziel dieser Studie besteht darin, die Konstitution und Merkmale der deutschen Varietät dieser böhmischen Einwanderergruppe im Kontakt mit dem Hunsrückischen als dominierende Koine und dem Portugiesischen als Amtssprache Brasiliens zu erkennen. Diese Sprachkontakte spielen eine zentrale Rolle in der Dynamik der Variation; sie werden in einem Sprachkontinuum zwischen standardsprachlichen Merkmalen und dem Substandard beschrieben Es wird daher insbesondere 1. nach linguistischen Merkmalen gesucht, die mit dem ursprünglichen Repertoire der böhmischen Einwanderer verbunden sind. Man geht hinsichtlich dieses Repertoires von einer Diglossie aus, zwischen der Standardnorm für schriftliche und formelle Funktionen und einer basilektalen Varietät für die familiären und informellen Funktionen. 2. Hinsichtlich der Weiterentwicklung des Deutschen bei dieser böhmischen Gruppe werden ergänzend die Folgen des Kontakts mit der Hunsrückischen Koine beschrieben. 3. Durch den Vergleich mit dieser Koine wird der Grad der Präsenz von böhmischen Dialektmerkmalen in den verschiedenen sozialen Segmenten (diastratische und diagenerationelle Dimension) genauer erschlossen, sowie auch die sozialen Faktoren, die diese Entwicklung beeinflussen. Zum Schluss werden zur Kontrolle perzeptuelle Aspekte der Kennzeichnung der böhmischen Varietät im Kontakt zwischen den Sprechern beider Sprachgemeinschaften erfasst (diarreferentielle Dimension). Um die gesprochene Variation und sprachliche Gestaltung des Deutschen der böhmischen Gruppe zu analysieren, orientiert sich die vorliegende Untersuchung an den theoretischen und methodischen Prinzipien der pluridimensionalen und relationalen Dialektologie (THUN, 1998), wie im ALMA-H Projekt (Sprachkontaktatlas der deutschen Minderheiten im La Plata-Becken: Hunsrückisch, koordiniert von C. Altenhofen / UFRGS und H. Thun / Universität Kiel) durchgeführt Diese Perspektive versucht die Daten der sprachlichen Variation der Forschungsobjektsprache („deutschböhmische Varietät“) in verschiedenen Dimensionen der Analyse zu konfrontieren. Die diatopisch-kinetische Dimension enthält die Variation der Sprache zwischen der Ursprungsmatrix (Böhmen) und dem heutigen geographischen Gebiet (Brasilien), in der sich Einwanderer im Jahre 1873 niederließen. Die diagenerationelle Dimension konzentriert sich auf die Variation zwischen der älteren Generation (GII) und der jüngeren Generation (GI). Schließlich wird in der diastratischen Dimension auf der Basis kontrastierender Daten von Ca (mit Hochschulbildung) und Cb (bis zur Sekundarschule) die Rolle der Schulbildung näher präzisiert. Für die Datenerhebungen wurde einen Fragebogen verwendet, der auf dem Fragebogen des ALMA-H basiert und ausgewählte Variablen spezifisch für die Ziele der Untersuchung umfasst. Es wurden insofern Interviews mit vier Gruppen von Informanten durchgeführt (CaGII, CbGII, CaGI und CbGI), vier in Linha Brasil (als böhmisches Ort) und vier in Santa Manoela (als Hunsrückisches Vergleichsort). Dabei wurden nur wenige böhmische Merkmale erkannt und mit den verschiedenen Dimensionen korreliert Die Ergebnisse bestätigen die Hypothese, dass diese böhmischen Migranten zwar mit einer Diglossie kamen, in dem sie eine Varietät [+dialektal] für informelle Beziehungen und eine Varietät des Standarddeutschen [+Standard] für formale Funktionen verwendet haben, aber nach fast 145 Jahren einen starken Koineizierungsprozess nachweisen, durch diese Einwanderer ihr Deutsch an die hunsrückische Koine angepasst haben und praktisch durch sie ersetzt haben. Es überleben lediglich vereinzelte basilektale Formen der Ursprungsmatrix (Böhmen), obwohl überwiegend als passive Kenntnisse (die nur zum Teil in Erinnerung kommen) und fast ausschließlich in der älteren Generation (CbGII). Dieser Verlust verschärft sich im Gegensatz dazu immer mehr bei Sprechern der jüngeren Generation (GI), die zunehmend zur Hunsrückischen Varietät übergeht, sowie auch des Portugiesischen als herrschende Amtssprache. / A presente pesquisa ocupa-se com a variação do alemão falado por descendentes de imigrantes boêmios na comunidade de Linha Brasil, autodenominada ‘Eestreich’ (Hdt: Österreich), em Paverama, no Rio Grande do Sul (RS), Brasil. Esse grupo de imigrantes instalou-se na localidade por volta de 1873, em uma área em que já estavam hunsriqueanos (Hunsrückisch) e outros grupos. O conceito de boêmio refere-se à matriz de partida dos imigrantes alemães na Boêmia (parte da atual República Tcheca), que na época da emigração pertencia ao antigo Império Austro-Húngaro (1867-1918). No Brasil estes imigrantes entraram em contato não somente com o português, mas também com outras variedades do alemão, em especial com o Hunsrückisch falado na comunidade vizinha de Santa Manoela (autodenominada de ‘Russland’) e demais comunidades do entorno. O objetivo central deste estudo é identificar como se formou o alemão falado pelos boêmios. Para isso, consideram-se os contatos linguísticos presentes na comunidade, entre as variedades da matriz de origem (possivelmente a norma local do Hochdeutsch e uma variedade dialetal de uso familiar) e as variedades do novo meio, especialmente o português e o hunsriqueano como coiné dominante. Assim sendo, este estudo envolve os seguintes objetivos específicos: 1) descrever as marcas linguísticas associadas à variedade dos imigrantes boêmios na sua comparação com a variedade da coiné hunsriqueana; 2) verificar o grau de presença de marcas mais dialetais do boêmio nos diferentes segmentos sociais (dimensão diastrática e dimensão diageracional), identificando os fatores sociais que atuam na conservação ou perda dessas marcas; e 3) analisar a percepção dos falantes e o significado social dessas marcas no contato com as demais variedades (dimensão diarreferencial) Para analisar a variação e configuração linguística do alemão falado pelo grupo boêmio, este estudo se orienta pelos pressupostos teórico-metodológicos da Dialetologia Pluridimensional e Relacional (THUN, 1998), como vem sendo praticada pelo projeto ALMA-H (Atlas Linguístico-Contatual das Minorias Alemãs na Bacia do Prata: Hunsrückisch), coordenado por C. Altenhofen (UFRGS) e H. Thun (Univ. Kiel, Alemanha). Essa perspectiva busca confrontar os dados da variação linguística da língua-objeto da pesquisa (o “alemão dos boêmios”) em diferentes dimensões de análise. Na dimensão diatópico-cinética considera-se a variação da língua entre a matriz de origem (Böhmen) e a área geográfica atual (RS), onde os imigrantes se fixaram em 1873. A dimensão diageracional se foca na variação entre a geração mais velha (GII) e a mais jovem (GI). Por fim, na dimensão diastrática analisa-se o papel da escolaridade, contrastando os dados da Ca (com a escolaridade superior) e da Cb (até segundo grau). Para a coleta de dados foi utilizado um questionário reduzido, a partir do questionário-base do Projeto ALMA-H, e adaptado no sentido de selecionar variáveis relevantes para atingir os objetivos deste estudo. Deste modo, foram realizadas entrevistas e observações de campo com quatro grupos de informantes (CaGII, CbGII, CaGI e CbGI) em Linha Brasil (como núcleo boêmio) e em Santa Manoela (como ponto de comparação hunsriqueano), a fim de identificar as marcas distintivas do boêmio e sua correlação (perda ou manutenção) conforme as diferentes dimensões de análise Os resultados confirmam a hipótese de que estes imigrantes boêmios vieram com uma diglossia, em que usavam uma variedade [+dialetal] para as relações informais e uma variedade [+standard] do Hochdeutsch para funções formais, mas também confirmam um forte processo de coineização que levou os boêmios a acomodarem sua fala à coiné do Hunsrückisch. No entanto, algumas formas basiletais da matriz de origem (Böhmen) resistiram a esse processo, embora sobrevivam predominantemente como conhecimento passivo, especialmente de falantes da geração mais velha (GII). Por outro lado, a geração jovem (GI) ainda possui o conhecimento ativo do hunsriqueano, contudo tende a substituir cada vez mais esta variedade de imigração pelo frequente uso do português. / The current research investigates the variation of the German language spoken by descendants of Bohemian immigrants in the community of Linha Brasil, self-named 'Eestreich' (standard German: Österreich), in Paverama, Rio Grande do Sul (RS), Brazil. This group of immigrants settled in the locality around 1873, in an area in which there were already Hunsrückisch speakers and other groups. The concept of Bohemian refers to the starting matrix of German immigrants in Bohemia (part of the present Czech Republic), which at the time of emigration belonged to the former Austro-Hungarian Empire (1867-1918). In Brazil, these immigrants had contact not only with Portuguese, but also with other varieties of German, especially the Hunsrückisch, spoken in the neighboring community of Santa Manoela (self-named 'Russland') and other surrounding communities. The main purpose of this study is to identify the German spoken by Bohemian immigrants, considering all the linguistic contacts present in this community. There are language varieties from the matrix of origin, possibly the local standard German and a dialectal variety of family use, besides the varieties of the new environment, especially the Portuguese and the Hunsrückisch as dominant koine. Therefore, this study involves the following specific objectives: 1) to describe the linguistic marks associated with the variety of Bohemian immigrants, comparing them with the variety of the Hunsrückisch's koine; 2) to verify the presence the degree of more dialectal Bohemian marks in the different social segments (diastratic dimension and diagenerational dimension), identifying the factors that contributed for conserving or losing these marks; and 3) to analyze the perception and social meaning of these marks by the speakers, in the contact with the other varieties (diarreferential dimension) To analyze the variation and linguistic configuration of German spoken by the Bohemian group, the study is guided by the theoretical and methodological principles of Pluridimensional and Relational Dialectology (THUN, 1998), as it has been practiced by the ALMA-H project (Linguistic Contact Atlas of German Minorities in Río de La Plata Basin: Hunsrückisch), coordinated by C. Altenhofen (UFRGS) and H. Thun (University of Kiel, Germany). This perspective tries to confront the data of the linguistic variation of the research-object language (the "Bohemian German dialect") in different dimensions of analysis. The variation of the language between the origin matrix (Böhmen/Bohemia) and the current geographical area (Brazil) is considered under the diatopic-kinetic dimension, where immigrants settled in 1873. The diagenerational dimension focuses on the variation between the older generation (GII) and the younger generation (GI). Ultimately, in the diastratic dimension, the sholarity role is analyzed by comparing the data from Ca (from secondary school to university) against the Cb (from the illiterate to those who finished nine years of school). For data collection, a reduced questionnaire was used based on the ALMA-H questionnaire and adapted to select relevant variables to achieve the purposes of this study. Thus, interviews and field observations were carried out with four informants groups (CaGII, CbGII, CaGI e CbGI) in Linha Brasil (as a bohemian nucleus) and in Santa Manoela (as a point of Hunsrückisch comparison) in order to identify the distinctive marks of the Bohemian and their correlation (loss or maintenance) according to the different dimensions of analysis The results confirm the hypothesis that these Bohemian immigrants came with a diglossia, in which they used a variety [+ dialect] for informal relationships and a variety [+ standard] of the standard German for formal functions. They also confirm a strong koineisation process that led the Bohemians to accommodate their speech to the Hunsrückisch's koine. However, some basilect forms of the origin matrix (Bohemia) resisted this process, although they survive predominantly as passive knowledge, especially of speakers of the older generation (GII). On the other hand, although the young generation (GI) still has the active knowledge of the Hunsrückisch, they tend to replace this variety of immigration more and more by the frequent use of Portuguese.

In my Diploma Thesis, I focused on quality and quantity of the social contacts of elderly persons above 70 years of age. This Diploma Thesis is divided into two parts. Part one is a theoretical application of terms age and aging, demographical aging of the current population, age conditioned changes, needs of elderly, socio-psychological aspects of age, social substance of age and the important meaning of elderly life. And last but not least is elderly welfare and social security scheme. The second part is practical. Another target of my thesis is to ascertain elderly above 70 years of age suppositions to establish social contacts and relationships, and what are the contact?s quantity and quality in their surroundings and how are they satisfied with those contacts. I have compared results in three different environments in which the elderly live. To achieve set targets I chose qualitative research. This research had three sections: identification questions, questions in accordance with WHO DAS II scale and open questioning. Elemental company made a group of thirty elderly persons between 70 ? 85 years of age. I approached those seniors in their common environment, in a nursing home or home for the elderly. The research results showed that social contacts are fully dependent on family functionality and friendly contacts. A senior who has lost his or her life partner often loses even many social contacts. This fact may even contribute to social isolation, which significantly affects the individual's state of health. Elderly are also insufficiently informed about opportunities to establish social contacts. This fact also negatively affects their socialization.