O estado de ansiedade pré-competitiva e seu possível relacionamento com o desempenho esportivo tem se tornado foco de investigação por diversos pesquisadores, principalmente na área da psicologia do esporte. Entretanto, na modalidade futsal, essa relação ainda encontra-se pouco explorada. Assim o objetivo geral do estudo foi verificar a relação entre ansiedade pré-competitiva e o desempenho esportivo em atletas profissionais de futsal durante os playoffs de um campeonato esportivo. Adicionalmente, buscou-se analisar a possível influência entre a condição de jogo (dentro e fora de casa) e fase do campeonato (quartas de final, semifinal e final) sob as respostas de ansiedade e desempenho, além de aplicar a Teoria da Catástrofe para testar a interação entre ansiedade, excitação fisiológica e desempenho. Para tanto o estudo analisou 16 atletas do sexo masculino de futsal, da categoria sub-20, pertencentes a um clube de elite, do estado de São Paulo, Brasil. O estudo foi conduzido durante os playoffs de um campeonato de alta importância para a equipe, sendo as coletadas realizadas nos jogos em casa e fora de casa, nas fases de quartas de final, semifinal e final. Em cada jogo, a coleta ocorreu entre 15 a 30min antes do aquecimento da equipe, sendo avaliados o estado de ansiedade pelo CSAI-2R e a excitação fisiológica pela VFC. O desempenho esportivo foi analisado subjetivamente pelo técnico (questionário em escala Likert). Os tratamentos estatísticos utilizados foram: ANOVA 2x3 para análise da influência da condição e fase do campeonato; a correlação de Pearson para analisar a correlação entre as variáveis analisadas e a regressão linear múltipla que compôs os cálculos da Teoria da Catástrofe. Para todas as análises, foram considerados um alfa de 5%. Como principais resultados destaca-se a relação positiva e significativa da excitação fisiológica e do desempenho entre as diferentes fases da competição. Correlações significativas foram estabelecidas entre as variáveis analisadas, entretanto a maioria delas classificadas como \"moderada\". Através da Teoria da Catástrofe foi possível observar uma positiva interação entre ansiedade, excitação fisiológica e desempenho esportivo. Através dos resultados encontrados, podemos concluir que: o estado de ansiedade pré-competitiva e o desempenho esportivo apresentam uma relação negativa em atletas de futsal. Esta relação pode ser observada com a aplicação da Teoria da Catástrofe, no qual sob altos níveis de ansiedade cognitiva, o desempenho do atleta de futsal tende a diminuir, apenas quando estado de excitação fisiológica estiver elevado. Podemos ainda concluir que a fase da competição pode influenciar significativamente no comportamento dos atletas, através de um aumento no nível de excitação fisiológica conjuntamente com um melhor desempenho com o passar das fases / The pre-competitive state anxiety and it´s possible relationship with the sport performance has become a focus of investigation for many researchers, especially in sport psychology. However in the sport futsal, this relationship is still inconclusive. Thus, the aim of this study was to investigate the relationship between pre-competitive anxiety and performance of professional athletes of futsal during the playoffs of a championship. Furthermore, in this study the possible influence of the phase and game condition on the anxiety and performance responses was analyzed, additionally, the Catastrophe Theory was used to see the interaction amongst cognitive anxiety, arousal and performance responses. To develop this study, 16 male professional futsal athletes were analyzed, belonging to an elite club of São Paulo, Brazil. The study was conducted throughout the playoffs of an important championship on high level for the team. The samples were collected in home and away venue in phases of quarterfinals, semifinals and finals. The data were collected about 15 to 30 minutes before the warm-up in each game, in which the anxiety by CSAI-2R and the physiological arousal by HRV were evaluated. Performance was analyzed subjectively (Likert Scale questionnaire) and objectively (match analysis). The used statistics treatments were: the ANOVA 2x3 for analyzing the influence of phase and game condition; the Pearson\'s correlation for testing the correlation among the variables (state anxiety, physiological arousal and performance) and for the Catastrophe Theory followed specific statistical tests. For all analyzes the alpha was set on 5%. Among the main results we identified a significant influence of the phase of competition for the pre-competitive physiological arousal and the subjective performance. Significant correlations were found among the variables, however, the majority of them was classified as \"moderate\". The Catastrophe Theory presented a positive application on the interaction among anxiety, physiological arousal by HRV indices and performance. Concerning the findings, we can conclude that the pre-competitive state of anxiety and the performance showed a negative relationship in futsal athletes. This relationship can be observed in the Catastrophe Theory, when under high levels of cognitive anxiety, decrease their performance as a function of the increase of physiological arousal. Beyond that, we can conclude that the phase of the game can influence the athlete\'s behavior. When the phase of championship increases, the athletes show a higher level of physical arousal, plus the great subjective performance

O estado de ansiedade pré-competitiva e seu possível relacionamento com o desempenho esportivo tem se tornado foco de investigação por diversos pesquisadores, principalmente na área da psicologia do esporte. Entretanto, na modalidade futsal, essa relação ainda encontra-se pouco explorada. Assim o objetivo geral do estudo foi verificar a relação entre ansiedade pré-competitiva e o desempenho esportivo em atletas profissionais de futsal durante os playoffs de um campeonato esportivo. Adicionalmente, buscou-se analisar a possível influência entre a condição de jogo (dentro e fora de casa) e fase do campeonato (quartas de final, semifinal e final) sob as respostas de ansiedade e desempenho, além de aplicar a Teoria da Catástrofe para testar a interação entre ansiedade, excitação fisiológica e desempenho. Para tanto o estudo analisou 16 atletas do sexo masculino de futsal, da categoria sub-20, pertencentes a um clube de elite, do estado de São Paulo, Brasil. O estudo foi conduzido durante os playoffs de um campeonato de alta importância para a equipe, sendo as coletadas realizadas nos jogos em casa e fora de casa, nas fases de quartas de final, semifinal e final. Em cada jogo, a coleta ocorreu entre 15 a 30min antes do aquecimento da equipe, sendo avaliados o estado de ansiedade pelo CSAI-2R e a excitação fisiológica pela VFC. O desempenho esportivo foi analisado subjetivamente pelo técnico (questionário em escala Likert). Os tratamentos estatísticos utilizados foram: ANOVA 2x3 para análise da influência da condição e fase do campeonato; a correlação de Pearson para analisar a correlação entre as variáveis analisadas e a regressão linear múltipla que compôs os cálculos da Teoria da Catástrofe. Para todas as análises, foram considerados um alfa de 5%. Como principais resultados destaca-se a relação positiva e significativa da excitação fisiológica e do desempenho entre as diferentes fases da competição. Correlações significativas foram estabelecidas entre as variáveis analisadas, entretanto a maioria delas classificadas como \"moderada\". Através da Teoria da Catástrofe foi possível observar uma positiva interação entre ansiedade, excitação fisiológica e desempenho esportivo. Através dos resultados encontrados, podemos concluir que: o estado de ansiedade pré-competitiva e o desempenho esportivo apresentam uma relação negativa em atletas de futsal. Esta relação pode ser observada com a aplicação da Teoria da Catástrofe, no qual sob altos níveis de ansiedade cognitiva, o desempenho do atleta de futsal tende a diminuir, apenas quando estado de excitação fisiológica estiver elevado. Podemos ainda concluir que a fase da competição pode influenciar significativamente no comportamento dos atletas, através de um aumento no nível de excitação fisiológica conjuntamente com um melhor desempenho com o passar das fases / The pre-competitive state anxiety and it´s possible relationship with the sport performance has become a focus of investigation for many researchers, especially in sport psychology. However in the sport futsal, this relationship is still inconclusive. Thus, the aim of this study was to investigate the relationship between pre-competitive anxiety and performance of professional athletes of futsal during the playoffs of a championship. Furthermore, in this study the possible influence of the phase and game condition on the anxiety and performance responses was analyzed, additionally, the Catastrophe Theory was used to see the interaction amongst cognitive anxiety, arousal and performance responses. To develop this study, 16 male professional futsal athletes were analyzed, belonging to an elite club of São Paulo, Brazil. The study was conducted throughout the playoffs of an important championship on high level for the team. The samples were collected in home and away venue in phases of quarterfinals, semifinals and finals. The data were collected about 15 to 30 minutes before the warm-up in each game, in which the anxiety by CSAI-2R and the physiological arousal by HRV were evaluated. Performance was analyzed subjectively (Likert Scale questionnaire) and objectively (match analysis). The used statistics treatments were: the ANOVA 2x3 for analyzing the influence of phase and game condition; the Pearson\'s correlation for testing the correlation among the variables (state anxiety, physiological arousal and performance) and for the Catastrophe Theory followed specific statistical tests. For all analyzes the alpha was set on 5%. Among the main results we identified a significant influence of the phase of competition for the pre-competitive physiological arousal and the subjective performance. Significant correlations were found among the variables, however, the majority of them was classified as \"moderate\". The Catastrophe Theory presented a positive application on the interaction among anxiety, physiological arousal by HRV indices and performance. Concerning the findings, we can conclude that the pre-competitive state of anxiety and the performance showed a negative relationship in futsal athletes. This relationship can be observed in the Catastrophe Theory, when under high levels of cognitive anxiety, decrease their performance as a function of the increase of physiological arousal. Beyond that, we can conclude that the phase of the game can influence the athlete\'s behavior. When the phase of championship increases, the athletes show a higher level of physical arousal, plus the great subjective performance

Les limites rencontrées par les dernières générations de mémoires Flash et DRAM (Dynamic Random Access Memory) nécessitent la recherche de nouvelles variables physiques (autres que la charge et la tension), de nouveaux dispositifs ainsi que de nouvelles architectures de circuits. Plusieurs dispositifs à résistance variable sont très prometteurs. Parmi eux, les OxRRAMs (Oxide Resistive Random Access Memory) et les CBRAMs (Conductive Bridge Random Access Memory) sont de sérieux candidats pour la prochaine génération de mémoire dense. Ce travail se concentre donc sur le rôle des mémoires résistives (OxRRAM et CBRAM) dans les mémoires embarquées et plus particulièrement dans les FPGAs. Pour cela, nous avons développé un modèle compact, outil indispensable à la conception de circuits intégrés. Ensuite, nous avons conçus de nouveaux circuits non volatiles tels que des flips-flops (NVFF), des tables de correspondance (NVLUT), des commutateurs 2x2 ainsi que des SRAMs (NVSRAM). Ces structures ont finalement été simulées dans le cas d’un FPGA, afin de vérifier l’impact de celles-ci sur la surface, le délai ainsi que la puissance. Nous avons comparé les résultats pour un FPGA à base de NVLUTs utilisant une structure 1T-2R composée de CBRAMs par rapport à un FPGA plus classique utilisant des SRAMs. Nous réduisons ainsi la taille de 5%, la consommation de 18% et améliorons la vitesse de fonctionnement de 24%. La thèse aborde la modélisation compacte, la conception des circuits, et l’évaluation de systèmes incluant des mémoires résistives. / The grave challenges to future of traditional memories (flash and DRAM) at 1X nm regime has resulted in increased quest for new physical state variables (other than charge or voltage), new devices and architectures offering memory and logic functions beyond traditional transistors. Many thin film devices with resistance change phenomena have been extensively reported as ’promising candidates’. Among them, Ox- ide Resistive Memory (OxRRAM) and Conductive Bridge Resistive Memory (CBRAM) are leading contenders for the next generation high density memories. In this work, we focus on the role of Resistive Memories in embedded memories and their impact on FPGAs in particular. We begin with the discussion on the compact modeling of resistive memory devices for design enabling, we have designed novel circuits of non- volatile flip-flop (NVFF), non-volatile look-up table (NVLUT), non-volatile 2x2 switch and non-volatile SRAM (NVSRAM) using Resistive Memories. We simulated the impact of these design structures on the FPGA system assessing the performance parameters of area, delay and power. By using the novel 1T-2R memory element concept of CBRAMs in FPGAs to implement Look-up Tables (NVLUT), we would scale down the area impact by 5%, enhance speed by 24% and reduce the power by 18% compared to SRAM based FPGAs. The thesis addresses aspects of compact modeling, circuit design and system evaluation using resistive memories.

Selon l'OMS, les troubles dépressifs majeurs (TDM) seront la 2ème cause d'incapacité dans le monde en 2020 et deviendront la 1ère en 2030. Les antidépresseurs classiques ont des effets thérapeutiques retardés et de nombreux patients sont résistants. La kétamine, antagoniste du récepteur N-methyl-D-aspartate (R-NMDA) du L-glutamate, possède un effet antidépresseur rapide chez les patients résistants à un traitement classique. Le mécanisme de cette activité étonnante n'est pas bien compris. En couplant la microdialyse intracérébrale à un test comportemental prédictif d'une activité antidépressive dans un modèle de souris BALB/cJ de phénotype anxieux, nous montrons que cette activité de la kétamine dépend de la balance excitation-inhibition entre les systèmes glutamate/R-NMDA et R-AMPA, GABA/R-GABAA, sérotonine du circuit cortex préfrontal/noyau du raphé. Nos résultats suggèrent également que ce serait la combinaison [kétamine-(2R,6R)-hydroxynorkétamine, son principal métabolite cérébral] qui porterait l'effet antidépresseur. Mes travaux de thèse contribuent à une meilleure compréhension de l'effet rapide antidépresseur de la kétamine. / According to the WHO, major depressive disorder (MDD) will be the second leading cause of disability in the world in 2020 and will become the first in 2030. Conventional antidepressant drugs have delayed therapeutic effects and many patients are resistant. Ketamine, an N-methyl-D-aspartate (NMDA-R) receptor antagonist of L-glutamate, exerts a rapid antidepressant effect in patients who are resistant to standard therapy. The mechanism of this amazing activity is not well understood. By coupling intracerebral microdialysis to a predictive behavioral test of antidepressant activity in a BALB/cJ mouse model with an anxious phenotype, we show that this ketamine activity is dependent on the excitation-inhibition balance between glutamate/NMDA-R and AMPA-R, GABA/GABAA-R, serotonin systems in the prefrontal cortex/raphe nucleus circuit. Our results also suggest that it would be the combination [ketamine-(2R,6R)-hydroxynorketamine, its main brain metabolite] that would carry the antidepressant effect. My thesis work pave the way for the development of new fast-acting antidepressant drugs.

In this dissertation we present the research findings around two important hot topics of modern and future fiber-optic communication systems: 100 Gbit/s transmission and alloptical processing of received phase-modulated signals. The findings are discussed in the same chronological order they were obtained. Each topic is summarized in two chapters that correspond to one selected journal and one conference publications. The first and second chapters are dedicated to the simulation and numerical analysis of 100 Gbit/s systems. In chapter one, we present a thorough investigation of the best 100 Gbit/s serial modulation format. Seven different modulation formats are considered and are compared in terms of tolerance to dispersion and maximum reach for a 10⁻⁹ bit error rate target. In chapter two, the behavior of chapter one’s best candidate is analyzed in a realistic environment. The influence of the existing lower data rate neighboring channels is discussed in particular. The results of these two chapters were obtained in collaboration with engineers from the Deutsche Telekom Technology Center in Darmstadt, Germany. They served as a theoretical basis for a field trial carried out by this same company. Chapter three and four focus on the use of semiconductor optical amplifiers for all-optical processing applications. Impaired phased-modulated signals are under particular interest in this study. The novelty in this work resides in the counter-propagating configuration that the semiconductor optical amplifier is operated in. In chapter three we give a detailed description of the experimental results. The complete setup is explained and the improvement in Q-factor and bit error rate for the received signal is proven. Furthermore, two novel concepts (Photonic Balancing and Saturated Asymmetric Filtering) that explain the observed improvements are developed and discussed for the first time to the best of our knowledge. Finally, chapter four aims at optimizing numerically the experimental setup for the saturated asymmetric filtering technique. The required detuned filter after the saturated semiconductor optical amplifier is optimized in terms of both off set and bandwidth.

Submitted by Luciana Botelho Ribeiro (lulu_bribeiro@hotmail.com) on 2018-07-23T15:50:13Z No. of bitstreams: 2 PDF tese.pdf: 1175553 bytes, checksum: 67115840596c859b674749ece9bcd291 (MD5) PDF tese.pdf: 1175553 bytes, checksum: 67115840596c859b674749ece9bcd291 (MD5) / Rejected by Adriana Aparecida Puerta null (dripuerta@rc.unesp.br), reason: Prezada Luciana. O documento enviado para a coleção Campus Unesp Rio Claro foi recusado pelo seguinte motivo: Falta a folha de aprovação, que deve ser solicitada à Seção de Pós-Graduação e deve ser inserida após a ficha catalográfica. Em caso de dúvidas entre em contato pelo email repositoriounesp@reitoria.unesp.br. Agradecemos a compreensão e aguardamos o envio do novo arquivo. Atenciosamente, Biblioteca Campus Rio Claro Repositório Institucional UNESP https://repositorio.unesp.br on 2018-07-23T18:02:43Z (GMT) / Submitted by Luciana Botelho Ribeiro (lulu_bribeiro@hotmail.com) on 2018-07-23T19:55:37Z No. of bitstreams: 3 PDF tese.pdf: 1175553 bytes, checksum: 67115840596c859b674749ece9bcd291 (MD5) PDF tese.pdf: 1175553 bytes, checksum: 67115840596c859b674749ece9bcd291 (MD5) Tese FINAL.pdf: 1436444 bytes, checksum: 53443d2d0a8ee81995743c38d52e4150 (MD5) / Approved for entry into archive by Adriana Aparecida Puerta null (dripuerta@rc.unesp.br) on 2018-07-24T13:20:57Z (GMT) No. of bitstreams: 1 ribeiro_lb_dr_rcla.pdf: 1436444 bytes, checksum: 53443d2d0a8ee81995743c38d52e4150 (MD5) / Made available in DSpace on 2018-07-24T13:20:57Z (GMT). No. of bitstreams: 1 ribeiro_lb_dr_rcla.pdf: 1436444 bytes, checksum: 53443d2d0a8ee81995743c38d52e4150 (MD5) Previous issue date: 2018-07-02 / O objetivo deste trabalho foi investigar os níveis de ansiedade pré-competitiva de atletas universitários sob a ótica da Teoria Bioecológica. Participaram 41 atletas universitários de ambos os sexos, praticantes de Handebol, Futsal ou Voleibol. A média de idade foi 22,10 anos. Foram utilizados o questionário de caracterização da amostra e o CSAI-2R. Nas análises entre grupos os atletas de Voleibol apresentam baixa autoconfiança e alta ansiedade comparado aos outros. Os atletas de Futsal apresentam autoconfiança superior aos demais. Intragrupo, os atletas de Futsal também apresentam valores elevados de autoconfiança e no Voleibol apresentam valores superiores de ansiedade e no Handebol apresentam baixa ansiedade somática. Em relação ao sexo os homens apresentam maior autoconfiança e as mulheres maior ansiedade somática. Explicando os valores de ansiedade em relação aos fatores da Teoria Bioecológica, os atletas conseguiram se desenvolver durante o processo do campeonato e mesmo sofrendo influências conseguiram criar situações que promovam o seu desenvolvimento na competição. Conclui-se que não há como pensar o indivíduo isoladamente de suas interações com as pessoas e o ambiente como um todo, o indivíduo deve ser analisado em todos os aspectos de acordo com a teoria Bioecológica pensar o indivíduo no processo, nas pessoas que o mesmo sofre e exerce influência, o contexto que este está inserido ou não e o tempo/período do seu desenvolvimento. / The objective of this study was to investigate the levels of pre - competitive anxiety of university athletes from the perspective of Bioecological Theory. 41 university athletes of both sexes participated, practicing Handball, Futsal or Volleyball. The mean age was 22.10 years. The sample characterization questionnaire and the CSAI - 2R were used. In the between analyzes groups the athletes of Volleyball pres ent low self - confidence and high anxiety compared to the other athletes. Futsal athletes are more confident than others. Intragroup, Futsal athletes also have high values of self - confidence and in Volleyball they present higher values of anxiety and in Handball they present low somatic anxiety. In relation to sex, men have greater self - confidence and women have greater somatic anxiety. Associating the Bioecological Theory, the athletes managed to develop during the process of the championship and even s uffering influences managed to create situations that promote their development in the competition. It is concluded that there is no way to think of the individual isolated from his interactions with people and the environment as a whole, the individual sh ould be analyzed in all aspects according to the Bioecological theory to think the individual in the process, in the people that the same suffers and exerts influence, the context that it is inserted or not and the t ime / period of its development.

Dans ce document, nous présentons une étude des caractéristiques d'absorbants saturables à multi-puits quantiques dopés au fer dans le cadre d'une régénération 2R tout optique de signaux à hauts débits. Après avoir situé le domaine d'application et rappelé les propriétés non-linéaires du matériau qui permettent l'utilisation de ces structures en tant que régénérateurs pour les télécommunications optiques. Nous exposons les méthodes de caractérisation et les résultats expérimentaux concernant ce composant, en s'intéressant plus particulièrement à des absorbants saturables insérés en cavité Fabry-Perot. Puis, nous étudions l'évolution des propriétés (longueur d'onde, contraste, temps de réponse et puissance optique de seuil des effets non-linéaires) en fonction de la polarisation du signal incident et de la température. Enfin, nous proposons les résultats préliminaires des performances de ce composant en configuration système à 10Gbit/s dans une boucle à recirculation de 91 kilomètres.

G-protein coupled receptors (GPCRs) have been shown to act as part of GPCR associated protein complexes (GAPCs) which are required to appropriately transduce downstream signaling pathways leading to specific cellular actions. I hypothesize that there are distinct molecular effectors that couple to the glucagon superfamily of B-class GPCRs (glucagon, GLP-1, GLP-2, GIP receptors) to effect the myriad of reported actions in numerous target cells including regulation of insulin secretion, intestinal growth and appetite suppression. GLP-1R, GIPR, GLP-2R and GCGR were screened using a newly developed membrane-based split-ubiquitin yeast two-hybrid (MYTH) system to reveal 181 novel candidate protein interactors associated with signal transduction, transport, metabolism and cell survival. Each candidate was validated using yeast two-hybrid prey retransformation tests and by co-purification to confirm coupling to each receptors. The present work is the first demonstration of a split-ubiquitin interaction screen using in situ membrane expressed GPCRs of the secretin-like B class.

G-protein coupled receptors (GPCRs) have been shown to act as part of GPCR associated protein complexes (GAPCs) which are required to appropriately transduce downstream signaling pathways leading to specific cellular actions. I hypothesize that there are distinct molecular effectors that couple to the glucagon superfamily of B-class GPCRs (glucagon, GLP-1, GLP-2, GIP receptors) to effect the myriad of reported actions in numerous target cells including regulation of insulin secretion, intestinal growth and appetite suppression. GLP-1R, GIPR, GLP-2R and GCGR were screened using a newly developed membrane-based split-ubiquitin yeast two-hybrid (MYTH) system to reveal 181 novel candidate protein interactors associated with signal transduction, transport, metabolism and cell survival. Each candidate was validated using yeast two-hybrid prey retransformation tests and by co-purification to confirm coupling to each receptors. The present work is the first demonstration of a split-ubiquitin interaction screen using in situ membrane expressed GPCRs of the secretin-like B class.

No description available.