Please read the abstract in the section 00front of this document / Thesis (PhD (New Testament Studies))--University of Pretoria, 2007. / New Testament Studies / unrestricted

This diploma thesis deals with the development of the institutional safeguarding of environmental protection in the Czech Republic during the last 30 years, mainly protection of environmental media. The beginning of the diploma thesis is dedicated to the development of the environmental policy of the state. I focused mainly on targets of environmental policy, which deals with institutional assurance. Next chapter describes the development of the constitutional framework of environmental protection. Moreover describes the basic features of environmental law. Following chapter deals with the development of the system of public authorities which participates in environmental protection. Chapter is divided into three subchapters by time period: 80's, years 1990- 1992 and after 1993. Subchapter is divided from national public authorities to regional and local public authorities and public guards. The final chapter describes the development in the field of environmental media's protection, including institutional assurance of the offence liability. Moreover describes the development in waste management. Chapter focuses mainly on the development of the public administration in environmental protection. Each subchapter is dedicated to one environmental medium and divided by time period: 80's, 90's and...

Les entérovirus (EV) sont des agents étiologiques de nombreuses pathologies chez les adultes et les enfants, y compris la poliomyélite qui a été éradiquée en France. Aujourd’hui, la surveillance d’EV se déroule dans le cadre de la vigilance post-éradication, et fournit des données épidémiologiques importants sur des entérovirus non polio.A Marseille, la surveillance a amené à l’analyse de 654 souches isolées entre 1985 et 2005. Les EV de l'espèce B étaient prédominants, parmi lesquels l’echovirus 30 (E30) a été le plus fréquemment isolé et l’E13 a émergé lors de l’épidémie en 2000. Notre analyse des souches cliniques sur 20 ans renforce la stratégie de sérotypage par la VP1. L'analyse phylogénétique a identifié des souches de différents sérotypes, avec des régions nonstructurales génétiquement proches associées aux VP1 divergents. Ceci contredit le modèle actuel de la recombinaison et pourrait être à l’origine de l'émergence d’E13 épidémique.Deux épidémies majeures d’E30 ont été décrites en 2000 et 2005. Entre elles, le protocole de diagnostic d’EV a été modifié: en 2000, la détection s’est fait par la culture cellulaire et la RT-PCR classique; en 2005, la technique de la RT-PCR en temps réel a été utilisée. Ainsi, l’épidémie de 2005 a été caractérisée par une réduction significative du délai nécessaire de livrer les résultats du diagnostic et de la durée du séjour hospitalier.Nous avons également adapté un système moléculaire pour la détection d'EV71. EV71 est associé à des épidémies du syndrome pied, main, bouche en Asie, mais peut aussi engendrer des complications neurologiques fatales. Nous avons testé 365 échantillons positifs pour l’EV. 3 cas d'EV71 du génogroupe C2 ont été détectés entre 2009 et 2011 chez les enfants sans histoires de voyage récent, ce qui confirme la circulation actuelle de ce génogroupe en France.Les entérovirus ont le potentiel de provoquer des épidémies fréquentes, à cause de leur diversité génétique importante et de leur capacité de réémergence. Il est nécessaire de maintenir la surveillance d'EV par la détection et l'analyse des virus en circulation, et de développer d’autres techniques rapides de détection et d’identification. / Enteroviruses are single-stranded RNA viruses associated with a myriad of pathologies in adult and paediatric populations, the most notable of which, poliomyelitis, has been eradicated in France. Today, enterovirus surveillance is carried out in the context of post-eradication monitoring, and provides important epidemiological data for nonpolio enteroviruses.In Marseille, surveillance efforts culminated in the compilation and analysis of 654 strains isolated between 1985 and 2005. Predominant serotypes belonged to the B species: Echovirus 30 (E30) was the most frequently isolated serotype and E13 emerged during the 2000 epidemic. Our analysis of clinical strains over 20 years lends credence to the VP1 serotyping strategy. Phylogenetic analysis identified strains of different serotypes which were genetically similar in the nonstructural regions despite distinct VP1 regions. This observation contradicts the current model of recombination and could explain the emergence of epidemic E13.Two large outbreaks of E30 were described in 2000 and 2005, in between which EV diagnostic protocol was changed: in 2000, detection was performed using cell culture and classic RT-PCR techniques; in 2005, this was done via real-time RT-PCR. As a result, the 2005 outbreak was characterised by a significant decrease in the time needed to deliver diagnostic results, as well as in the length of hospital stay.We also adapted a real-time molecular assay for the detection of EV71. EV71 is associated with major outbreaks of hand, foot and mouth disease in the Asia-Pacific region, but can also cause fatal neurological complications. We screened 356 EV-positive samples and detected three cases of genogroup C2 EV71 infection between 2009 and 2011 in young children with no history of travel, confirming the current circulation of EV71 in France.Enteroviruses have the potential to cause frequent epidemics, due to their great genetic diversity and their propensity for re-emergence. This underscores the need to maintain EV surveillance by analysing past and present circulating viruses, as well as to develop more rapid detection and identification techniques.

This thesis examines the nature of New Testament church worship and seeks to understand the concept of worship among first-century Christians. Chapter 1 describes the misconceptions held by present-day worshipers and presents unusual scholarly positions. Chapter 2 analyzes the eight Greek words that are translated "worship" in the New Testament. Two words, [Special characters omitted.]<math> <f> <g>p</g><g>r</g>o<g>s</g><g>k</g><g>u</g><g>n</g><a><ac><g>e</g> </ac><ac>&d12;</ac></a><g>w</g></f> </math> and [Special characters omitted.]<math> <f> <g>l</g><g>a</g><g>t</g><g>r</g><g>e</g><a><ac><g>u</g></ac><ac>&d12;</ac></a> <g>w</g></f> </math> , stand out in both frequency of use and importance of meaning. Chapter 3 examines six passages that deal specifically with worship. Portions of Matthew 2, John 4, Romans 12, 1 Corinthians 14, Hebrews 9, and Revelation 7 are analyzed in order to understand the contextual setting of worship. Chapter 4 offers conclusions based on chapters 2 and 3. First-century worship is understood to focus on God primarily, with congregational ministries being of subsequent importance. / This item is only available to students and faculty of the Southern Baptist Theological Seminary. If you are not associated with SBTS, this dissertation may be purchased from <a href="http://disexpress.umi.com/dxweb">http://disexpress.umi.com/dxweb</a> or downloaded through ProQuest's Dissertation and Theses database if your institution subscribes to that service.

Esta tese trata da produção em disco e teatro de revista do cantor carioca Francisco Alves entre 1920 e 1932, período que marcou sua consagração como intérprete. Procura mapear através de sua carreira, a trajetória e o papel do disco e do teatro de revista enquanto seus mediadores, comparando-os como meio de circulação e fixação das músicas gravadas e interpretadas por Alves. Através de uma pesquisa realizada em jornais e revistas da época, na primeira parte do trabalho foi feito um levantamento das peças em que atuou e nos arquivos da companhia teatral recuperados trechos e falas dos personagens que representou. Essa primeira parte engloba de 1920 e 1926, período que atuou como ator secundário no Teatro São José e gravou sem sucesso alguns discos nas gravadoras Popular e Casa Edison. A maneira como estas canções circularam nas festas populares e no teatro de revista foi abordada assim como uma comparação dos modos de produção do teatro e da indústria fonográfica. A segunda parte engloba de 1927 e 1932 e marca uma inversão quantitativa na produção de peças de teatro e de discos na trajetória de Francisco Alves, quando foi consolidada sua consagração. Foi enfocada a maneira como as músicas gravadas por ele passaram a se redimensionar nos palcos e ele a se definir como cantor, se articulando com a gravadora, compositores e outros cantores através de seu posicionamento enquanto agente nas diferentes instâncias de mediação. Neste período a ascensão de Francisco Alves coincidiu com a de vários gêneros musicais urbanos e a tese mostrará o caminho deles para o disco e o teatro e entre um e outro meio. / This thesis focuses on the artistic record and musical revue production by Rio de Janiro (carioca) singer Francisco Alves between 1920 and 1932. Such period is known for bringing the artist\'s consecration as a performer. By recovering his career we try to map the trajectory and role of record and theater production in Brazil as mediator compared to the means of circulation and establishment of the songs recorded and performed by Alves. Through extensive research recovering newspapers and magazines of the time, the first part of our work brings the history of the plays Francisco Alves participated in, also searching the archives of the theater companies he worked for and the lines of the characters he impersonated. Thus, the first part of the thesis recovers from 1920 to 1926, period in which Alves was still a secondary performing actor working in the Theater São José and would release a few songs trough the recording companies Popular and Casa Edison. The way such songs have circulated in national popular parties and in the musical revue tradition was taken into account, pointing to the specific means of production of the theater and the music industry. The second part of the thesis ranges from 1927 e 1932 and it marks a quantitative turn in the production of songs and plays in the trajectory of Francisco Alves, consolidating his achievements. We are interested in the way the songs he recorded were staged and how the artist started to be defined as a true singer, articulated with recording companies, composers and other singers. We also consider his role as an agent in many instances of cultural mediation during that time. Finally, the emergence of Francisco Alves has coincided with that of many urban musical genres. This work intends to show the path recovered by those genres in order to be recorded and/or gain the theater, caught in the middle of one and other medium.

O presente trabalho propõe avaliar a habilidade do Modelo Regional Climático, versão 4, (RegCM4) em simular a variabilidade temporal e espacial do sinal associado à propagação da Oscilação de Madden-Julian (OMJ) nos trópicos. A avaliação foi feita através da comparação dos dados observados obtidos do conjunto da Reanálise do ERA-Interim e dos dados simulados pelo RegCM4, para o período de 2005 a 2009. Foram utilizados dados globais diários de precipitação, Radiação de Onda Longa Emergente e componentes zonal do vento em 850 e 200 hPa, provenientes da Reanálise do ERA-Interim, tanto na simulação, quanto nos dados observados. Como condição inicial do modelo, optou-se pela utilização da banda tropical, cujo principal aspecto é o de simular características tanto da circulação quanto dos padrões de precipitação tropicais. Para a validação do modelo, foi utilizada a precipitação diária do Global Precipitation Climatology Project (GPCP). Todos os dados foram filtrados na escala de 30-60 dias a fim de se observar o sinal referente à OMJ. A análise dos padrões globais de precipitação e Radiação de Onda Longa (ROL), após filtragem, permitiu a seleção de cinco áreas, com sinais associados à OMJ, sendo elas: África (AFR), Indonésia (IND), Norte da América do Sul (NAS), Nordeste brasileiro (NEB) e Sudeste brasileiro (SEB). A área NEB, apresentou valores de correlação linear de 0,63 e 0,32 para a anomalia e anomalia de ROL filtrada, respectivamente. Já a área SEB, apresentou valores de correlação linear de 0,30 e 0,54, para a anomalia e anomalia de ROL filtrada. O BIAS calculado entre o modelo e a precipitação do GPCP, para as estações secas (MAI-OUT) e chuvosas (NOV-ABR) mostrou que para a América do Sul, Sul do continente Africano e Índico, o modelo superestima os valores de precipitação do GPCP nas duas estações do ano. Quanto à análise multivariada entre a ROL, vento zonal em 850 e 200 hpa a comparação com o obtido para os dados do Era-Interim, a Empirical Orthogonal Function (EOF1) aplicada aos dados do RegCM4 apresenta convecção e inibição da convecção em áreas distintas da faixa longitudinal entre 15º N e 15º S. Enquanto os valores mínimos de EOF1 para ROL (intensificação da convecção) do Era-Interim são observados próximo a 90º L, os valores mínimos de ROL para os dados do RegCM4 são observados próximos à 120º O, com defasagem longitudinal de 30º. L, enquanto os valores máximos da EOF1 para ROL (inibição de convecção) do Era-Interim são observados próximo a 150º L, os valores máximos para os dados simulados pelo RegCM4 são observados próximos à 60º L, com uma defasagem longitudinal de 90°. / The present work proposes to evaluate the ability of the Regional Climatic Model (RegCM4) to simulate the temporal and spatial variability of the signal associated with the propagation of the Madden-Julian Oscillation in the tropics. The evaluation was done by comparing the observed data obtained from the Reanalysis of the ERA-Interim and the data simulated by RegCM4, for the period from 2005 to 2009. Daily global data were used for precipitation, Emergent Long Wave Radiation and zonal wind components at 850 and 200 hPa from the ERA-Interim Reanalysis, both in the simulation and in the observed data. As initial conditions of the model, we chose to use the tropical band, whose main characteristic is to simulate the circulation and the tropical precipitation patterns. The validation of the model was performed with the daily precipitation of the Global Precipitation Climatology Project (GPCP). All data were filtered in the 30-60 day scale in order to observe the signal concerning the MJO. The analysis of the global precipitation and Outgoing Longwave Radiation (OLR) patterns, after filtration, allowed the selection of five areas, with signs associated to the MJO, being: Africa (AFR), Indonesia (IND), North of South America (NAS), Northeast Brazil (NEB) e Southeast Brazil (SEB). The NEB area presented linear correlation values of 0,63 and 0,32 for the anomaly and filtered anomaly of OLR, respectively. The SEB area presented linear correlation values of 0.30 and 0.54 for the anomaly and anomaly of filtered OLR. The BIAS calculated between the model and GPCP precipitation for the dry (MAY-OCT) and rainy seasons (NOV-APR) showed that for South America, South Africa and Indian continent, the model overestimates precipitation values of GPCP in the two seasons. The multivariate analysis between OLR, zonal wind at 850 and 200 hp compared to that obtained for Era-Interim data, the EOF1 applied to RegCM4 data presents convection and convection inhibition in different areas between 15º N and 15º S. While the minimum Empirical Orthogonal Function (EOF1) values for OLR (convection enhancement) of the Era-Interim are observed close to 90º E, the minimum OLR values for the RegCM4 data are observed close to 120º O, with a longitudinal lag of 30º. And while maximum EOF1 values for OLR (convection inhibition) of the ERA-Interim are observed close to 150º E, the maximum values for the simulated data by RegCM4 are observed close to 60º E, with a longitudinal lag of 90º.

O objetivo da presente dissertação de mestrado é propor uma análise de parte das crônicas humorísticas de Benedito Bastos Barreto, o Belmonte. A análise desta produção literária, escrita entre 1932 e 1935, tem como eixo as temáticas mais constantes na escrita de Belmonte: a rejeição do governo de Getúlio Vargas e do Nazi-fascismo e as severas críticas à modernidade técnica. Em suas críticas ao Nazi-fascismo, elaboradas na primeira metade da década de trinta do século passado, o cronista demonstrou precocidade e ineditismo frente aos jornalistas e jornais paulistas da época, sendo que estes tendiam a se calar ou a demonstrar simpatia perante a ascensão dos governos Fascistas de Hitler e Mussolini. E, ao elaborar críticas à modernidade técnica, sugerimos que Belmonte não apenas repudiava o incrível potencial bélico demonstrado com ineditismo na Primeira Guerra Mundial , como também apontava para a complexa e problemática modernização da cidade de São Paulo, assim como a aspectos atribulados da sua história recente. / The purpose of the present dissertation is to propose an analysis of some humoristic chronicles of Benedito Bastos Barreto, the Belmonte. The analysis of this literary work, written between 1932 and 1935, has the most often thematics on Belmontes writing as main point: the rejection of Getúlios Vargas government and of the Nazi-fascism, as well as the severe critics to the technical modernity. In his critics against the Nazi-fascism, elaborated during the first half of the thirties of the last century, the chronist demonstrates to be precoce and unheard of when compared to the jornalists and the newspapers of his time, for those used to keep quiet or demonstrate appreciation for the rising of Hitlers and Mussolinis fascist governments. And, as he elaborates critics to the techincal modernity, we sugest that Belmonte did not just repudiate the amazing warlike potencial that was demonstrated for the first time on the First World War , as well as he also indicates the complex and problematic modernization of São Paulo city, and the troubled aspects of its recent history.

Made available in DSpace on 2016-04-28T20:39:08Z (GMT). No. of bitstreams: 1 Bruna Tokunaga Dias.pdf: 1127970 bytes, checksum: 25ad06ff934e50244c2bc7eb1c5136b1 (MD5) Previous issue date: 2015-09-04 / This research seeks to identify and understand the career transition issues in the 30 years period between 28 and 33 years. We conducted a qualitative study of Jungian theoretical base with 4 participants between 28 and 31 years. We use semistructured interview and a job with figures. Considering career as possible satisfaction and dissatisfaction field, we tried to understand the issues in young adults in contemporary times, the reasons for dissatisfaction and the projection of an ideal that participants want for their lives and careers. The analysis suggests that the main reasons related to dissatisfaction are related to routine and demands of the workplace and lack of quality of life. The participants wish to build a family, to evolve spiritually, balance and tranquility. It stands out as contribution of this research to understand the people of career questions which consider themselves dissatisfied during the transition of 30 years / A presente pesquisa visa identificar e compreender as questões de carreira na transição dos 30 anos, período compreendido entre os 28 e os 33 anos . Para tanto, realizamos uma pesquisa qualitativa de base teórica junguiana com 4 participantes entre 28 e 31 anos. Utilizamos entrevista semidirigida e um trabalho com figuras. Considerando-se a carreira como possível campo de satisfação e insatisfação, procurou-se compreender os questionamentos de carreira de adultos jovens na contemporaneidade, motivos de insatisfação e a projeção de um ideal do que os participantes desejam para suas vidas e carreiras. A análise sugere que os principais motivos relacionados à insatisfação estão relacionados à rotina e exigências do ambiente de trabalho e falta de qualidade de vida. Os participantes desejam construir uma família, evoluir espiritualmente, equilíbrio e tranquilidade. Destaca-se como contribuição desta pesquisa a compreensão dos questionamentos de carreira de pessoas as quais se consideram insatisfeitas, durante a Transição dos 30 anos

Une sous population de cellules au sein des tumeurs mammaires présente une capacité accrue de se renouveler et de reproduire l’hétérogénéité du cancer du sein. Maintenant il est bien connu que les cellules souches présomptives du cancer du sein possèdent des programmes d’expression des gènes qui correspondent à leurs caractéristiques biologiques uniques. Notre groupe a été impliqué dans la caractérisation épigénétique des cellules souches présomptives du cancer du sein et l’importance de la dérégulation des mécanismes épigénétiques comme la méthylation de l’ADN et le microARN au cours de la carcinogenèse. Plus spécifiquement cette étude détaille l’idée que la survie des cellules souches du cancer du sein peut être due à une signalisation via des circuits spécifiques de régulation, y compris la voie d’inflammation IL6-JAK-STAT. Ces cellules présentent une activation constitutive de cette voie associée à une configuration particulière de la chromatine. Une autre part de cette étude est d’explorer l’idée que des changements dans l’expression des microARN sont fondamentaux pour la maintenance des principales caractéristiques de ces cellules, et leur ciblage peut représenter une nouvelle approche de thérapie contre le cancer du sein. De plus, en testant directement les conséquences in vivo de la régulation de miR30a nous ouvrons la voie pour la recherche et la validation de l’utilisation potentielle des microARN comme thérapie anti cancéreuse. Ensemble, nos résultats apportent une nouvelle compréhension du rôle des modifications épigénétiques dans la maintenance des cellules souches du cancer du sein. De façon importante ces découvertes intègrent l’idée que des mécanismes de régulations différents mais coordonnés ont un rôle dans la survie des cellules souches du cancer du sien et donnent une perspective élargie pour la découverte de nouvelles cibles thérapeutiques / A subpopulation of cells within breast tumors is known to display an increased ability to self-renew and reproduce breast cancer cell heterogeneity. It is now known that putative breast cancer stem cells (CSCs) display distinct programs of gene expression that correlate with their unique biological characteristics. Our group has been involved in the epigenetic characterization of putative breast CSCs and the importance of the deregulation of epigenetic mechanisms such as DNA methylation and microRNA during carcinogenesis. More specifically, this study is detailing the idea that the survival of breast CSC may be dependent on signaling through specific regulatory circuits, including the well known inflammatory IL6-JAK-STAT pathway. These cells display a constitutive activation of this pathway associated with a distinct chromatin configuration. Another part of the study is exploring the idea that changes in microRNA expression are fundamental in sustaining the main attributes of these cells, and their targeting may represent a novel approach for breast cancer therapy. In addition, by directly testing the in vivo consequences of miR30a regulation, we open a window of opportunity for testing and validating the potential use of microRNAs in anti-neoplastic therapy. Together our results bring a new understanding of the role of epigenetic modifications in the maintenance of breast CSC. Importantly, these findings integrate the idea that different but coordinated regulation mechanisms play a role in the survival of CSC and give a larger perspective for finding novel therapeutic targets

O objetivo da presente dissertação de mestrado é propor uma análise de parte das crônicas humorísticas de Benedito Bastos Barreto, o Belmonte. A análise desta produção literária, escrita entre 1932 e 1935, tem como eixo as temáticas mais constantes na escrita de Belmonte: a rejeição do governo de Getúlio Vargas e do Nazi-fascismo e as severas críticas à modernidade técnica. Em suas críticas ao Nazi-fascismo, elaboradas na primeira metade da década de trinta do século passado, o cronista demonstrou precocidade e ineditismo frente aos jornalistas e jornais paulistas da época, sendo que estes tendiam a se calar ou a demonstrar simpatia perante a ascensão dos governos Fascistas de Hitler e Mussolini. E, ao elaborar críticas à modernidade técnica, sugerimos que Belmonte não apenas repudiava o incrível potencial bélico demonstrado com ineditismo na Primeira Guerra Mundial , como também apontava para a complexa e problemática modernização da cidade de São Paulo, assim como a aspectos atribulados da sua história recente. / The purpose of the present dissertation is to propose an analysis of some humoristic chronicles of Benedito Bastos Barreto, the Belmonte. The analysis of this literary work, written between 1932 and 1935, has the most often thematics on Belmontes writing as main point: the rejection of Getúlios Vargas government and of the Nazi-fascism, as well as the severe critics to the technical modernity. In his critics against the Nazi-fascism, elaborated during the first half of the thirties of the last century, the chronist demonstrates to be precoce and unheard of when compared to the jornalists and the newspapers of his time, for those used to keep quiet or demonstrate appreciation for the rising of Hitlers and Mussolinis fascist governments. And, as he elaborates critics to the techincal modernity, we sugest that Belmonte did not just repudiate the amazing warlike potencial that was demonstrated for the first time on the First World War , as well as he also indicates the complex and problematic modernization of São Paulo city, and the troubled aspects of its recent history.