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The Global ETD Search service is a free service for researchers
to find electronic theses and dissertations. This service is
provided by the
Networked Digital Library of Theses and Dissertations.
Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
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Showing 41 to 50 of 60 (0.011 seconds)| 41 |
Untersuchungen zur Wirksamkeit von Dacarbazin und Temozolomid bei der Behandlung des kutanen Melanoms in Assoziation mit DNA-Reparatur / Assessment of the Efficacy of Dacarbazine and Temozolomide in Melanoma Treatment in Association with DNA-RepairBöckmann, Lars 15 January 2010 (has links)
No description available.
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Entwicklung und Einsatz der Immun-SERS-Mikroskopie zur Gewebe-basierten TumordiagnostikSalehi, Mohammad 09 September 2013 (has links)
Surface-enhanced Raman scattering (SERS) microscopy is a novel method of optical imaging for the localization and quantification of target molecules in cells and tissue specimens. The major advantages of SERS over fluorescence are quantification and spectral multiplexing due to the small line width of vibrational Raman bands. The position of the plasmon band of both hollow gold/silver nanoshells and silica-encapsulated gold nanoclusters can be tuned for maximum SERS enhancement upon red laser excitation, which is optimal for minimizing the disturbing autofluorescence of tissue. In this work, silica-encapsulated and non-encapsulated SERS particles were used for the localization of target proteins in prostate tissue specimens. Two different biofunctionalization methods were established for each type of SERS particles. The cross-linking method based on s-NHS/EDC chemistry was modified for covalently conjugating proteins to hollow gold/silver nanoshells and gold nanostars in order to minimize the aggregation of SERS nanoparticles during and after cross-linking. As an alternative to covalent conjugation chemistry, the noncovalent binding of antibodies to the SERS particles via an adapter protein (protein A/G) was established. The influence of several factors that determine the quality of results obtained by SERS imaging, such as the number of immuno-SERS conjugates, incubation time, antigen retrieval and blocking buffer, were investigated. Rapid SERS microscopy with 30 msec acquisition time per pixel was enabled by using silica-encapsulated gold nanoclusters for the localization of p63 proteins on prostate tissue specimens from healthy donors. Two-color SERS experiments for the parallel localization of PSA and p63 were performed with silica-encapsulated and non-encapsulated nanoshells. The quality of the results depends less on the nature of the surface chemistry of the nanoparticles (with or without silica encapsulation), but more on the blocking buffer and the antigen retrieval method. Silica-encapsulated gold nanoclusters were also used for the simultaneous quantification of three cytokines (IL1, IL8 and TNF- α) in a SERS-based sandwich immunoassay with a detection limit of ca. 0.3 pM.
Keywords: Raman, SERS microscopy, biocompatibility of nanoparticles, cross-linking, antigen unmasking methods, antigen detection, immunohistochemistry, immunoassay.
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"Eine vergleichende Genexpressionsanalyse von Gap- Junction- Strukturproteinen in oralen Plattenepithelkarzinomen und gesunder Schleimhaut" / A comparative gene expression study of gap-junction proteins in oral squamous cell carcinomas and normal mucosaBrodmann, Tobias 23 April 2012 (has links)
No description available.
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Onkogenomische Aspekte Zytokin-assoziierter Signaltransduktion / Oncogenomic aspects of cytokine-associated signal transductionSchoof, Nils 21 October 2008 (has links)
No description available.
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Die Bedeutung von Stanniocalcin 2 im humanen Neuroblastom / Relevance of Stanniocalcin 2 in human NeuroblastomaVolland, Sonja 21 January 2009 (has links)
No description available.
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| 46 |
Mechanismen der Durchbrechung der sekundären Antiöstrogenresistenz durch GnRH-Analoga in Mammakarzinomzellen / Mechanisms of breaking the secondary antiestrogen resistance with GnRH analogs in breast cancer cellsBlock, Martin 23 October 2009 (has links)
No description available.
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Einfluss von GnRH Analoga auf die Metastasierung humaner Mammakarzinomzellen in vitro und in vivo / Effect of GnRH analogs on the metastasis of human breast cancer cells in vitro and in vivoSchubert, Antje 25 October 2010 (has links)
No description available.
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Wirkung schwerer Ionen auf strahlenresistente und strahlensensitive Tumorzellen / Effect of heavy ions upon radioresistant and radiosensitive tumor cellsHofman-Hüther, Hana 31 October 2001 (has links)
No description available.
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Platelet surface receptors and melanoma metastasis / Plättchen-Oberflächenrezeptoren und Melanom-MetastasierungErpenbeck, Luise 18 May 2011 (has links)
No description available.
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Expression von Peptidyl-prolyl cis/trans isomerase NIMA-interacting 1 (PIN1) in Blasten von Patienten mit akuter myeloischer Leukämie / Expression of peptidyl-prolyl cis/trans isomerase NIMA-interacting 1 (PIN1) in blasts of patients with acute myeloid leukemiaHangen, Hanne 05 July 2011 (has links)
No description available.
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