Thesis (Ph.D.) -- University of Adelaide, Dept. of Clinical and Experimental Pharmacology, 2001. / Bibliography: leaves 234-257.

Thesis (M.A.)--Ball State University, 2009. / Title from PDF t.p. (viewed on Mar. 25, 2010). Research paper (M.A.), 3 hrs. Includes bibliographical references (p. [49]-53).

Mergers are a fact of life in the private sector and are increasingly becoming a factor in the public sector. Organisations seek to merge in order to survive or grow by accruing benefits of scale, better or cheaper access to resources or by overcoming barriers to entry into existing or new markets. Financial shocks can play a part in increasing merger activity (Andrade et al., 2001; Harford, 2004) and the tertiary education sector in Scotland has witnessed a number of mergers in the last two decades, the most recent of which have been at least in part driven by the need to reduce public expenditure. This study considered the guidance afforded to tertiary education institutions in Scotland and highlighted the paucity of support offered in the important area of bringing human resources (of potentially disparate organisations) together in a merger situation. The cultures of organisations were a primary focus, since they are the embodiment of the assumptions, values and behaviours which form the ‘soul' of an organisation. The study acknowledged the prevalence of financial and legal due diligence in the pre-merger phase, arguing that there should also be an explicit consideration of 'cultural due diligence' (CDD). An exploratory case study method was used to examine whether cultural aspects were investigated in a particular merger involving two Scottish colleges. A number of respondents, drawn from the governance, executive, management and supervisory strata were interviewed in order to ascertain the level to which cultural issues had been addressed at the pre- and post-merger stages. The research identified some activity pertaining to culture identification in the pre-merger stage but found little evidence that values and behaviours had been a specific focus, thereby suggesting that detailed cultural issues were not a priority at that stage in the process. The post-merger phase was characterised by a breakdown in interaction between the college executive and the remainder of the organisation precisely at a time where increased leadership and communications and the rebuilding of trust were called for. Based on the research findings, CDD is explicitly defined and a set of principles to guide the conduct of a CDD exercise are offered as a contribution to existing practice. Enhancements to the existing merger guidance are made relating to CDD, continuous monitoring of progress towards a new culture by both governors and the executive and the selection and profile of leaders in a merger. Finally, a number of suggestions for future research are made in support of the premise that organisational culture and CDD in particular are important elements of any merger.

Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde. Programa de Pós-Graduação em Ciências Médicas. / Made available in DSpace on 2012-10-22T22:46:04Z (GMT). No. of bitstreams: 1 235242.pdf: 663338 bytes, checksum: eeaf08a18f8ac5465bab02755126cfc5 (MD5) / Introdução: O tacrolimus é um agente imunossupressor isolado do Streptomyces tsukubaensis e é utilizado principalmente na prevenção de rejeição de órgãos. Além disso, muitos trabalhos têm demonstrado o uso do tacrolimus em doenças de caráter inflamatório crônico como à asma brônquica e artrite reumatóide.

Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde. Programa de Pós-Graduação em Farmácia. / Made available in DSpace on 2012-10-23T23:45:16Z (GMT). No. of bitstreams: 1 251003.pdf: 562113 bytes, checksum: 2e6d39d6a93c258d38f3f5ad1667ebfc (MD5) / Introdução: Tacrolimus é um imunossupressor da classe dos macrolídeos utilizado na clínica para evitar a regeição em transplantes de órgãos e no tratamento da dermatite atópica. Objetivo: O objetivo do presente estudo foi elucidar a atividade antiinflamatória do tacrolimus na inflamação induzida pela carragenina, no modelo da bolsa de ar, em camundongos. Metodologia: Camundongos albinos Swiss receberam injeção de 1,5 ml de ar no dorso, durante três dias alternados, para formação da bolsa de ar. No sexto dia, os animais receberam carragenina (Cg, 1%, s.c.) e 24 h após foram sacrificados e a bolsa foi aberta e lavada com 1 ml de salina estéril. Os parâmetros inflamatórios observados foram: acúmulo de leucócitos, exsudação, atividade da mieloperoxidase (MPO) e da adenosina-deaminase (ADA), concentração de nitrato/nitrito (NOx) e níveis de fator de necrose tumoral alfa (TNF- ), interleucina-1 beta (IL-1 ) e quimiocina para neutrófilo (KC) foram avaliados 24 h depois. Para avaliar a exsudação, 1 h antes da Cg foi administrado 0,2 ml de azul de Evans (25 mg/kg, i.v.). Para determinação da curva dose e tempo resposta, inicialmente diferentes grupos de animais receberam diferentes doses de tacrolimus (1 a 10 mg/kg, v.o.) 0,5 h antes da injeção de carragenina e a migração celular e a exsudação foram avaliadas 24 h após. Em outros experimentos, diferentes grupos receberam uma única dose de tacrolimus (2 mg/kg, v.o.) em diferentes períodos de tempo (0,5 - 4 h) e os parâmetros inflamatórios foram avaliados 24 h após. De acordo com este protocolo, tacrolimus (2 mg/kg, v.o.) administrado 0,5 h antes da Cg, foi utilizado para analisar o seu efeito sobre a atividade de MPO e ADA e níveis de NOx, TNF- , IL-1 e KC. A indometacina (5 mg/kg, i.p.) e a dexametasona (0,5 mg/kg, i.p.) foram utilizadas como fármacos de referência. Os resultados foram expressos como média ± erro padrão da média. As diferenças estatísticas foram determinadas pela análise de variância (ANOVA), seguido de teste de Dunnett ou teste t de Student. Valores de P < 0,05 foram considerados significantes. Resultados: O tacrolimus (Tac: 2 mg/kg, v.o.) inibiu o acúmulo de leucócitos e de neutrófilos e reduziu a exsudação, os níveis de TNF- , IL-1, KC e óxido nítrico, além da atividade da MPO e da ADA (P < 0,05). Conclusão: Estes resultados demonstram que o tacrolimus apresenta importante atividade antiinflamatória, similar a da indometacina e da dexametasona. A inibição de citocinas pró-inflamatórias (TNF- , IL-1, KC), enzimas (MPO e ADA) e liberação de mediadores inflamatórios (NOx) parecem fazer parte da atividade antiinflamatória do tacrolimus.

Die Standortnotwendigkeit ist Problem und Chance für Unternehmen (Standortsuche) und Standorte (Standortmarketing) gleichermaßen. Unternehmen sind dabei dem Einfluss durch die Gewichtung von Shareholder- und/oder Stakeholderinteressen unterworfen und der Wirkung harter wie weicher Standortfaktoren ausgesetzt. Die klassische Standortlehre allein stellt dabei nur einen unzureichenden Handlungsablauf dar. Ihr gegenüber ist die Annahme eines Standortfaktorenmix mit objektiven wie subjektiven Kriterien sinnvoller. Die Standortanalyse klassischer Ansätze kann durch verhaltens- und strukturorientierte Vorgehensweisen sinnvoll erweitert werden, um dem Situationsgemenge aus ökonomischem Ziel, unternehmerischer Situation und subjetiver Standortentscheidung besser gerecht zu werden. Die Annahme vollständiger Produktionsverlagerung weicht der Verlagerung einzelner Wertschöpfungsstufen innerhalb einer Wertschöpfungskette. Ein vernünftiger Analyse- und Entscheidungprozess muss daher ganzheitlicher erfolgen und führt dann zu besser abgesicherten Antworten auf die Fragen nach dem "was" wird "weshalb" notwendigerweise "wohin" verlagert.:Einleitung . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 1 Das Unternehmen . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 1.1 Beziehungen zur Umwelt . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 1.2 Einflussfaktoren . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 1.3 Shareholder oder der eigentu¨merbezogene Standpunkt. . . . . . . . . . . . . . . . . . 6 1.4 Stakeholder oder der gesellschaftspolitische Standpunkt . . . . . . . . . . . . . . . . . 7 1.5 Unternehmerische Verantwortung und Standortwahl. . . . . . . . . . . . . . . . . . . . 7 1.6 Standortstrategien . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10 2 Der Standort. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11 2.1 Standortlehre . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11 2.1.1 Klassischen Ansatze . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11 2.1.2 Neue Konzepte . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12 2.2 Standortfaktoren . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13 2.2.1 Begriff . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13 2.2.2 Harte Standortfaktoren . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 14 2.2.3 Weiche Standortfaktoren . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15 2.2.4 Bedeutung der Standortfaktoren fu¨r die Standortwahl . . . . . . . . . . . . . . . . 15 2.3 Standortwettbewerb . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 17 2.3.1 Drei Ebenen . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 17 2.3.2 Kanale des Standortwettbewerbes . . . . . . . . . . . . . . . . . . . . . . . . . . 19 2.4 Standortmarketing . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 20 2.4.1 Bedeutung . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 20 2.4.2 Standortmarketing am Beispiel des Regionalen Wachstumskerns Spremberg . . . 23 3 Das Problem . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 26 3.1 Bedeutung der Standortwahl . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 26 3.2 Standortanalyse . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 28 3.2.1 Klassische, normative Ansatze. . . . . . . . . . . . . . . . . . . . . . . . . . 28 3.2.2 Behavioristischer Ansatz bzw. Modell von Pred . . . . . . . . . . . . . . . . . . . . 33 3.2.3 Struktureller Ansatz . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 35 3.3 Standortentscheidung und Verlagerung . . . . . . . . . . . . . . . . . . . . . . . . . . 37 3.3.1 Prozess der Standortentscheidung . . . . . . . . . . . . . . . . . . . . . . . . . . 37 3.3.2 Prozess der Verlagerung . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 39 4 Zusammenfassung . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 42 Literaturverzeichnis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 46

Bibliography: leaves 234-257. Three separate clinical studies in organ transplant recipients are presented. The aims are to examine fundamental questions regarding the clinically and economically important pharmokinetic interaction between diltiazem and cyclosporin, an interaction widely utilised in organ transplantation. The data contained should assist the development of soundly based policies that will ensure a benefit exists before a sparing agent is coprescribed, and that the lowest effective dose of sparing agent is used.

In this study photocatalytic antibacterial and self-cleaning activities of TiO2-SiO2 thin films as a function of TiO2/SiO2 ratios were investigated. TiO2-SiO2 mixed oxides were synthesized by sol-gel method and coated over soda-lime glass plates by dip coating technique. Escherichia coli was used as a model microorganism for the photocatalytic antibacterial tests. Degradation rate of methylene blue (MB) molecules was used to characterize photocatalytic self-cleaning activities of thin film surfaces. The maximum antibacterial activity was achieved over 92 wt% SiO2 containing thin films. However, when the SiO2 content exceeds 92 wt%, photocatalytic antibacterial activity decreased considerably, which was explained by the dilution of TiO2 phase and inaccessibility of TiO2. Increase in photocatalytic antibacterial activity was attributed to increases in the relative surface area, roughness, hydroxyl (OH-) groups and bacterial adhesion. The favored bacterial adhesion enhanced direct contact of bacteria with TiO2 particles and surface reactive oxygen species. The highest initial decomposition rate of MB was obtained for 60 wt% SiO2 and the activity decreases as SiO2 concentration increases. The increase in photocatalytic activity by the SiO2 addition can be explained by the increase of the amount of MB per unit area of TiO2-SiO2 thin films. Different adsorption capability of thin films against MB molecule and E. coli cell was explained as the first reason why the antibacterial and self-cleaning activities reached their maximum values at different SiO2 ratios. The second reason could be related with the different control mechanisms of self-cleaning and antibacterial activities by different textural and surface properties.

Discharge estimations at certain cross sections of streams are very important for hydrologic studies especially for designs. In this study, it is aimed to determine regional mathematical equations that represent annual and monthly average discharges at desired locations using basin characteristics obtained with Geographical Information Systems (GIS) techniques and regression analysis. Study area covers three river basins, which are Gediz, K&uuml / &ccedil / &uuml / k Menderes and B&uuml / y&uuml / k Menderes. The data used are Digital Elevation Model (DEM), monthly average discharges observed at stream gauging stations and monthly total precipitation data from the precipitation observation stations in the study area. Stream networks are delineated from DEM using a GIS software. The basin parameters obtained from DEM are drainage area, total river length, main channel slope, main channel length and mean basin slope. Precipitation amount is also included in the analyses as the sixth parameter to improve the results. Using these parameters annual and monthly average discharge equations are determined and the best equation for each month is found based on the adjusted coefficient of determination values and stepwise regression analysis. Three models, each representing a different basin and a general model that represents the whole study area are developed. The verification of the models is made using the discharges at the additionally chosen stations that are not included in the model development. An interface that acquires the drainage area for a certain cross section and estimates the discharge according to the desired regression equation is written using arc objects and visual basic programming language. At the end, regression analysis results of the models are assessed and interpreted.

In this work, slurries of powder catalysts are washcoated on 22 mm diameter and 13 mm height cordierite monoliths. CeO2-ZrO2 (CZO) and CeO2-ZrO2- Al2O3 (CZAO) mixed oxides are synthesized by co-precipitation and sol-gel methods respectively, to be used as support materials of Pd and Rh metals. Metal loaded CZO is mixed with gamma phase alumina. Powder catalysts and their slurries are characterized by XRD, BET, ICP-MS and the monolithic catalysts are imaged by SEM. Catalytic activities of monolithic catalysts are tested in dynamic test system which is computerized and basically composed of gas flow control and conditioning units, split furnace, quartz reactor, mass spectrometer and CO analyzer. Gas mixture containing CO, C3H6, C3H8, NO, H2, O2, CO2, SO2, H2O and N2 is used to simulate the exhaust gas of gasoline vehicles. O2 is oscillated at 1 Hz frequency around the stoichiometric condition. Monolithic catalyst in the reactor is heated and cooled between 150 &ordm / C and 600 &ordm / C. Gas composition data from massspectrometer and CO analyzer and temperature data from thermocouple at the monolith entrance, are converted to conversion versus temperature graphs. Results of 26 activity tests are compared. Catalyst containing coimpregnated CZO support material with metals, showed the lowest loss of catalytic performance after exposure to SO2 during activity tests. Catalyst containing separately impregnated CZO support material, showed the highest resistance against thermal aging at 900 &ordm / C and 1000 &ordm / C, and even improved catalytic activity after aging. These catalysts showed higher resistances against the applied procedures than the commercial catalyst.