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The Global ETD Search service is a free service for researchers
to find electronic theses and dissertations. This service is
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Networked Digital Library of Theses and Dissertations.
Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
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Showing 141 to 150 of 180 (0.014 seconds)| 141 |
The Role of the Retinal Pigment Epithelium in Sorsby Fundus DystrophyWolk, Alyson M. 26 January 2021 (has links)
No description available.
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Secondary Mineral Coating Formation and Metal Sequestration in Soils Developing from Mine Spoil Pre- and Post-Treatment with LimeCole, Kortney Ann 01 November 2021 (has links)
No description available.
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Transcriptional and Distributional Profiling of Microglia in Retinal Angiomatous ProliferationSchlecht, Anja, Wolf, Julian, Boneva, Stefaniya, Prinz, Gabriele, Braunger, Barbara M., Wieghofer, Peter, Agostini, Hansjürgen, Schlunck, Günther, Lange, Clemens 07 February 2024 (has links)
Macular neovascularization type 3, formerly known as retinal angiomatous proliferation
(RAP), is a hallmark of age-related macular degeneration and is associated with an accumulation of
myeloid cells, such as microglia (MG) and infiltrating blood-derived macrophages (MAC). However,
the contribution of MG and MAC to the myeloid cell pool at RAP sites and their exact functions
remain unknown. In this study, we combined a microglia-specific reporter mouse line with a mouse
model for RAP to identify the contribution of MG and MAC to myeloid cell accumulation at RAP and
determined the transcriptional profile of MG using RNA sequencing. We found that MG are the most
abundant myeloid cell population around RAP, whereas MAC are rarely, if ever, associated with late
stages of RAP. RNA sequencing of RAP-associated MG showed that differentially expressed genes
mainly contribute to immune-associated processes, including chemotaxis and migration in early RAP
and proliferative capacity in late RAP, which was confirmed by immunohistochemistry. Interestingly,
MG upregulated only a few angiomodulatory factors, suggesting a rather low angiogenic potential. In
summary, we showed that MG are the dominant myeloid cell population at RAP sites. Moreover, MG
significantly altered their transcriptional profile during RAP formation, activating immune-associated
processes and exhibiting enhanced proliferation, however, without showing substantial upregulation
of angiomodulatory factors.
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Immunosenescence in Choroidal Neovascularization (CNV): Transcriptional Profiling of Naïve and CNV-Associated Retinal Myeloid Cells during AgingSchlecht, Anja, Thien, Adrian, Wolf, Julian, Prinz, Gabriele, Agostini, Hansjürgen, Schlunck, Günther, Wieghofer, Peter, Boneva, Stefaniya, Lange, Clemens 02 February 2024 (has links)
Immunosenescence is considered a possible factor in the development of age-related macular
degeneration and choroidal neovascularization (CNV). However, age-related changes of myeloid
cells (MCs), such as microglia and macrophages, in the healthy retina or during CNV formation are illdefined.
In this study, Cx3cr1-positive MCs were isolated by fluorescence-activated cell sorting from
six-week (young) and two-year-old (old) Cx3cr1GFP/+ mice, both during physiological aging and
laser-induced CNV development. High-throughput RNA-sequencing was performed to define the
age-dependent transcriptional differences in MCs during physiological aging and CNV development,
complemented by immunohistochemical characterization and the quantification of MCs, as well as
CNV size measurements. These analyses revealed that myeloid cells change their transcriptional
profile during both aging and CNV development. In the steady state, senescent MCs demonstrated
an upregulation of factors contributing to cell proliferation and chemotaxis, such as Cxcl13 and Cxcl14,
as well as the downregulation of microglial signature genes. During CNV formation, aged myeloid
cells revealed a significant upregulation of angiogenic factors such as Arg1 and Lrg1 concomitant
with significantly enlarged CNV and an increased accumulation of MCs in aged mice in comparison
to young mice. Future studies need to clarify whether this observation is an epiphenomenon or a
causal relationship to determine the role of immunosenescence in CNV formation.
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Development of a diatom based index of biotic integrity for acid mine drainage impacted streamsZalack, Jason T. January 2006 (has links)
No description available.
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| 146 |
Sustainable Treatments of Acid Mine DrainageGoetz, Elaine R. January 2015 (has links)
No description available.
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| 147 |
Homéostasie des fluides et pathophysiologies dans la rétine : l’épithélium rétinien pigmentéBenoit-Bélanger, Élodie 08 1900 (has links)
Les altérations de la barrière hémato-rétinienne (BRB) sont associées à des maladies rétiniennes
telles que la rétinopathie diabétique et la dégénérescence maculaire liée à l’âge
(DMLA). L’intégrité de la BRB est cruciale pour maintenir un microenvironnement rétinien
en homéostasie et est étroitement régulé grâce à la régulation du transport transcellulaire et
paracellulaire. Ici, nous décrirons brièvement la BRB interne, en mettant davantage l’accent
sur la structure et la fonction de la BRB externe dans les états sains et malades. Nous avons
hypothétisé que le dysfonctionnement des aquaporines exprimées dans des composantes de la
BRB est suffisant pour générer un oedème diabétique dans une rétine diabétique. Bien que les
résultats indiquent qu’aucune des aquaporines ciblées n’est suffisante pour générer un oedème
cystoïde dans un modèle murin - et ce même en l’exacerbant en augmentant la perméabilité
vasculaire rétinienne, nous mettons à l’avant un outil de segmentation semi-automatisé ainsi
que deux modèles de recherches engageants. Le modèle murin de DT1 induit via STZ a
été étudié de façon longitudinale sur un intervalle de temps modéré et pourra être ajusté
pour des expériences futures en mettant à profit un outil de quantification semi-automatique
performant. D’autre part, le modèle in vitro de la sénescence de l’ÉPR est conceptuellement
établi et partiellement mis sur pied. Finalement, les résultats sont prometteurs et incitent
à approfondir des cibles alternatives dans un modèle conceptuellement similaire, mais soit
exacerbé ou plus anatomiquement près de l’humain. / Alterations in the blood-retina barrier (BRB) are associated with retinal diseases such as
diabetic retinopathy and age-related macular degeneration (AMD). The integrity of the BRB
is crucial for maintaining a tightly regulated and retinal microenvironment in homeostasis
through the regulation of transcellular and paracellular transport. Here, we will briefly describe
the inner BRB, with a greater emphasis on the structure and function of the outer
BRB in both healthy and diseased states. We hypothesized that dysfunction of aquaporins
expressed in components of the BRB is sufficient to generate diabetic edema in a diabetic
retina. Although the results indicate that none of the targeted aquaporin are sufficient to
generate a cystoid edema in a murine model, even when exacerbated by increasing retinal
vascular permeability, we present a semi-automated segmentation tool and two engaging
research models. A murine model and a programmation tool were developped to efficiently
assess semi-automated quantitation of retinal edema. On the other hand, the in vitro model
of RPE senescence is conceptually established and partially implemented. Ultimately, the results
are promising and encourage further exploration of alternative targets in a conceptually
similar model, either exacerbated or more anatomically close to humans.
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| 148 |
OCT (Optical Coherense Tomography) : Teknik och tillämpningLundkvist, Stefan January 2013 (has links)
Before year 1895, the doctors could only make a probable diagnosis based on what the patient could tell and it was hurt and there was no discernable change to the outside of the body. With X-ray, it was possible to see inside the patient without first cutting it, you can say that the X-ray was the starting point for diagnostic imaging.The further development of X-ray gave CT (Computed Tomography), where X-ray tubes and detectors rotate around the patient while the patient table moves. Besides CT also developed MRI (Magnetic Resonance Imaging), PET (Positron Emission Tomography) and Ultrasound. Common to these methods is that the produced 3D images.In 1990 a completely new approach for diagnostic imaging, OCT (optical coherence tomography), by measuring the phase shift and the intensity of reflected light, it provides real-time and non-destructive measurements (in vivo) a resolution of 1 to 15 microns, much higher than all other standard imaging techniques. You could say that OCT machine can be compared to ultrasound, which uses the reflection of sound waves to interpretation.The first OCT machines were of type TD (Time Domain), these had low resolution and low scanning speed. In 2005 came the SD-OCT, they had higher resolution and scanning speed, SD stands for spectral domain, SD-OCT is sometimes called FD-OCT as Fourier transformed signals and operating in the frequency domain.The development of OCT machines are only in their infancy, resolution, scanning speed and accuracy will increase all the time, this allows new uses and ways to diagnose developed. OCT can be used in such Oncology, MSD (Musculoskeletal disorders), cardiovascular medicine, teeth, nerves, but the largest field is the eye and then the back of the eye called the retina (retina).This thesis is limited to the eye, the purpose is to provide input to those who are likely to purchase an OCT-machine, but also show the measurement data OCT-machines are performing and how to use the OCT-machine more than to see age-related macular degeneration. Another aim is to increase understanding of the physics behind an OCT-machine for ease of understanding the output given.The manufacture/model that have selected for evaluation are Zeiss Cirrus 4000, Topcon 3D OCT-2000 and Heidelberg Spectralis, the reason is that there are only these three on the Swedish market and all are SD-OCT. The way to evaluate OCT-machines is to scan performance and what the various analysis programs can handle. Furthermore, each OCT-machine scans the macula and optic disk on a experimental person/ reference eye, in order to get the output of the precision, or if you want to call it repeatability, which is very important if one wants to follow a solitary disease course.The conclusion of this thesis is to OCT machines are quite similar. When it comes to ease of use when doing scans is the Cirrus is lightened by the use of the extra screen where you always look eye (iris camera), which makes it easy to adjust the sharpness and position of the mouse buttons. Topcon and Heidelberg is not difficult to use but requires more experience of the person making the OCT scans. Most measurement functions in the analysis program is Topcon and Heidelberg and best accuracy/repeatability is Heidelberg, both the macula and RFNL.OCT machine is a good tool to use on the anterior segment, but in the case the precision allows the precision used to monitor RNFL thickness changes in those with glaucoma. / <p>Validerat; 20131029 (global_studentproject_submitter)</p>
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Funktionelle Charakterisierung der mit altersabhängiger Makuladegeneration (AMD) assoziierten Komplementfaktor-H-Variante Y402H / Functional characterization of Complement-factor-H-variant Y402H associated with age-related macular degeneration (AMD)Börncke, Florian 05 March 2012 (has links)
No description available.
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Neuartige Wirkmechanismen und Therapiestrategien von Glukokortikoiden in der Behandlung von Multipler Sklerose im Tiermodell / Novel mechanisms and therapeutic strategies of glucocorticoids in the treatment in an animal model of multiple sclerosisSchweingruber, Nils 25 June 2014 (has links)
No description available.
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