No / More than 1 billion people live in societies where consanguineous marriages are common. When children are born to consanguineous unions, there is an increased probability of the expression of single-gene disorders with a recessive mode of inheritance. There are presumptive social benefits of consanguineous marriages reported in the literature. METHODS: The UK's Born in Bradford birth cohort study recruited 12 453 women at 26-28 weeks' gestation between 2007 and 2010. In all, 11 396 completed a questionnaire, including questions about their relationship to their baby's father. We compared Pakistani and Other ethnic groups in consanguineous relationships and Pakistani, Other and White British groups not in consanguineous relationships, calculating percentages and age-adjusted prevalence ratios (95% confidence intervals). RESULTS: In the Pakistani group, 59.3% of women (n = 3038) were blood relatives of their baby's father. Consanguinity was uncommon in the Other ethnic group (7.3%, n = 127) and rare (n = 5) in the White British group. Compared with non-consanguineous counterparts, mothers in consanguineous relationships were socially and economically disadvantaged (e.g. never employed, less likely to have higher education). The Pakistani consanguineous group's social, economic and health lifestyle circumstances were equivalent to, in some cases better than, women in non-consanguineous relationships (e.g. up-to-date in paying bills, or in disagreeing that they wished for more warmth in their marital relationship). The consanguineous relationship group had less separation/divorce. Rates of cigarette smoking during pregnancy were lower in mothers in consanguineous relationships. CONCLUSION: Debate about consanguinity should balance the potential protective effect of consanguineous relationships with established genetic risk of congenital anomaly in children.

No / Congenital anomalies are a leading cause of infant death and disability and their incidence varies between ethnic groups in the UK. Rates of infant death are highest in children of Pakistani origin, and congenital anomalies are the most common cause of death in children younger than 12 in this ethnic group. We investigated the incidence of congenital anomalies in a large multiethnic birth cohort to identify the causes of the excess of congenital anomalies in this community. Methods: We obtained questionnaire data from the mothers of children with one or more anomalies from the Born in Bradford study, a prospective birth cohort study of 13 776 babies and their families in which recruitment was undertaken between 2007 and 2011. Details of anomalies were prospectively reported to the study and we cross checked these details against medical records. We linked data for anomalies to maternal questionnaire and clinical data gathered as part of the Born in Bradford study. We calculated univariate and multivariate risk ratios (RRs) with 95% CIs for various maternal risk factors. Findings: Of 11 396 babies for whom questionnaire data were available, 386 (3%) had a congenital anomaly. Rates for congenital anomaly were 305·74 per 10 000 livebirths, compared with a national rate of 165·90 per 10 000. The risk was greater for mothers of Pakistani origin than for those of white British origin (univariate RR 1·96, 95% CI 1·56–2·46). Overall, 2013 (18%) babies were the offspring of first-cousin unions. These babies were mainly of Pakistani origin—1922 (37%) of 5127 babies of Pakistani origin had parents in first-cousin unions. Consanguinity was associated with a doubling of risk for congenital anomaly (multivariate RR 2·19, 95% CI 1·67–2·85); we noted no association with increasing deprivation. 31% of all anomalies in children of Pakistani origin could be attributed to consanguinity. We noted a similar increase in risk for mothers of white British origin older than 34 years (multivariate RR 1·83, 95% CI 1·14–3·00). Maternal education to degree level was protective (0·53, 95% CI 0·38–0·75), irrespective of ethnic origin. Interpretation: Consanguinity is a major risk factor for congenital anomaly. The risk remains even after adjustment for deprivation, and accounts for almost a third of anomalies in babies of Pakistani origin. High levels of educational attainment are associated with reduced risk in all ethnic groups. Our findings will be valuable in health promotion and public health, and to those commissioning antenatal, paediatric, and clinical genetic services. Sensitive advice about the risks should be provided to communities at increased risk, and to couples in consanguineous unions, to assist in reproductive decision making. Funding: National Institute for Health Research Collaboration for Leadership in Applied Health Research and Care programme.

No / The present study aimed to explore previously unreported ethnic differences in infant feeding practices during the introduction of solid foods, accounting for maternal and birth factors, and to determine whether these feeding patterns are associated with BMI at 3 years of age. An observational study using Poisson regression was carried out to investigate the relationship between ethnicity and infant feeding practices and linear regression was used to investigate the relationship between feeding practices and BMI at 3 years of age in a subsample of 1327 infants in Bradford. It was found that compared with White British mothers, mothers of Other ethnicities were less likely to replace breast milk with formula milk before introducing solid foods (adjusted relative risk (RR) – Pakistani: 0·76 (95 % CI 0·64, 0·91), Other South Asian: 0·58 (95 % CI 0·39, 0·86), and Other ethnicities: 0·50 (95 % CI 0·34, 0·73)). Pakistani and Other South Asian mothers were less likely to introduce solid foods early ( < 17 weeks) (adjusted RR – Pakistani: 0·92 (95 % CI 0·87, 0·96) and Other South Asian: 0·87 (95 % CI 0·81, 0·93)). Other South Asian mothers and mothers of Other ethnicities were more likely to continue breast-feeding after introducing solid foods (adjusted RR – 1·72 (95 % CI 1·29, 2·29) and 2·12 (95 % CI 1·60, 2·81), respectively). Pakistani and Other South Asian infants were more likely to be fed sweetened foods (adjusted RR – 1·18 (95 % CI 1·13, 1·23) and 1·19 (95 % CI 1·10, 1·28), respectively) and Pakistani infants were more likely to consume sweetened drinks (adjusted RR 1·72 (95 % CI 1·15, 2·57)). No association between infant feeding practices and BMI at 3 years was observed. Although ethnic differences in infant feeding practices were found, there was no association with BMI at 3 years of age. Interventions targeting infant feeding practices need to consider ethnicity to identify which populations are failing to follow recommendations.

Yes / Objectives Preterm birth (PTB) and small for gestational age (SGA) are major causes of perinatal mortality and morbidity. Previous studies indicated a range of risk factors associated with these poor outcomes, including maternal psychosocial and economic wellbeing. This paper will explore a range of psycho-social and economic factors in an ethnically diverse population. Methods The UK’s Born in Bradford cohort study recruited pregnant women attending a routine antenatal appointment at 26–28 weeks’ gestation at the Bradford Royal Infirmary (2007–2010). This analysis includes 9680 women with singleton live births who completed the baseline questionnaire. Data regarding maternal socio-demographic and mental health were recorded. Outcome data were collected prospectively, and analysed using multivariate regression models. The primary outcomes measured were: PTB (<37 weeks’ gestation) and SGA (<10th customised centile). Results After adjustment for socio-demographic and medical factors, financial strain was associated with a 45 % increase in PTB (OR 1.45: 95 % CI 1.06–1.98). Contrary to expectation, maternal distress in Pakistani women was negatively associated with SGA (OR 0.65: CI 0.48–0.88). Obesity in White British women was protective for PTB (OR 0.67: CI 0.45–0.98). Previously recognized risk factors, such as smoking in pregnancy and hypertension, were confirmed. Conclusions This study confirms known risk factors for PTB and SGA, along with a new variable of interest, financial strain. It also reveals a difference in the risk factors between ethnicities. In order to develop appropriate targeted preventative strategies to improve perinatal outcome in disadvantaged groups, a greater understanding of ethno-specific risk factors is required

Yes / Objectives Congenital anomaly (CA) are a leading cause of disease, death and disability for children throughout the world. Many have complex and varying healthcare needs which are not well understood. Our aim was to analyse the healthcare needs of children with CA and examine how that healthcare is delivered. Design Secondary analysis of observational data from the Born in Bradford study, a large prospective birth cohort, linked to primary care data and hospital episode statistics. Negative binomial regression with 95% CIs was performed to predict healthcare use. The authors conducted a subanalysis on referrals to specialists using paper medical records for a sample of 400 children. Setting Primary, secondary and tertiary healthcare services in a large city in the north of England. Participants All children recruited to the birth cohort between March 2007 and December 2011. A total of 706 children with CA and 10 768 without CA were included in the analyses. Primary and secondary outcome measures Healthcare use for children with and without CA aged 0 to <5 years was the primary outcome measure after adjustment for confounders. Results Primary care consultations, use of hospital services and referrals to specialists were higher for children with CA than those without. Children in economically deprived neighbourhoods were more likely to be admitted to hospital than consult primary care. Children with CA had a higher use of hospital services (β 1.48, 95% CI 1.36 to 1.59) than primary care consultations (β 0.24, 95% CI 1.18 to 0.30). Children with higher educated mothers were less likely to consult primary care and hospital services. Conclusions Hospital services are most in demand for children with CA, but also for children who were economically deprived whether they had a CA or not. The complex nature of CA in children requires multidisciplinary management and strengthened coordination between primary and secondary care. / research by a PhD candidate supported by a Bradford University studentship, in conjunction with the White Rose Consortium, and the National Institute for Health Research (NIHR), Collaboration for Leadership in Applied Health Research and Care (CLAHRC) Yorkshire and Humber programme 'Healthy Children Healthy Families Theme', IS-CLA-0113-10020.

Le formalisme des fonctions de Green hors-équilibre (NEGF pour « Non-equilibrium Green’s function) a suscité au cours des dernières décennies un engouement fort pour étudier les propriétés du transport quantique des nanostructures et des nano-dispositifs dans lesquels les interactions inélastiques, comme la diffusion des électrons-phonons, jouent un rôle significatif. L'incorporation d'interactions inélastiques dans le cadre du NEGF s’effectue généralement dans l'approximation auto-cohérente de Born (SCBA pour « Self-consistent Born approximation) qui représente une approche itérative plus exigeante en ressources numériques. Nous proposons dans ce travail de thèse une méthode efficace alternative dite LOA pour (« Lowest Order Approximation. Son principal avantage est de réduire considérablement le temps de calcul et de décrire physiquement la diffusion électron-phonon. Cette approche devrait considérablement étendre l'accessibilité de l'utilisation de codes atomistiques de transport quantique pour étudier des systèmes 3D réalistes sans faire à des ressources numériques importantes. / Non-equilibrium Green’s function (NEGF) formalism during recent decades has attracted numerous interests for studying quantum transport properties of nanostructures and nano-devices in which inelastic interactions like electron-phonon scattering have a significant impact. Incorporation of inelastic interactions in NEGF framework is usually performed within the self-consistent Born approximation (SCBA) which induces a numerically demanding iterative scheme. As an alternative technique, we propose an efficient method, the so-called Lowest Order Approximation (LOA) coupled with the Pade approximants. Its main advantage is to significantly reduce the computational time, and to describe the electron-phonon scattering physically. This approach should then considerably extend the accessibility of using atomistic quantum transport codes to study three-dimensional (3D) realistic systems without requiring numerous numerical resources.

Bakgrund: Idag är det inte enbart stora och internationellt etablerade företag som verkar globalt. Fler och fler små och medelstora företag internationaliseras och är numera av stor betydelse för tillväxten i många länder. Dessa företag har visat förmåga att etablera sig internationellt, trots att tillgången till framförallt finansiella resurser kan tyckas begränsa deras internationaliseringsprocess. Snabbväxande företag finns inom alla sektorer, men givetvis finns en förhållandevis större andel tillväxtföretag i branscher och sektorer där marknaden och efterfrågan växer snabbt. Roxtec AB är ett snabbväxande industriföretag som vänder sig till industriella köpare inom tre stora sektorer, telekom, marin &amp; offshore och industri. Företagets produkt bygger på en ny idé om tätningar som används där extrem täthet behövs. Syfte: Syftet med uppsatsen är att beskriva etableringsprocessen och förklara de strategiska beslut som ligger bakom, då ett snabbväxande tillverkningsföretag ska etablera sig på en ny marknad. Genomförande: Data till den här uppsatsen samlades in genom intervjuer med fyra personer. De intervjuade var nyckelpersoner inblandade inom internationaliseringsprocessen, framförallt när det gäller strategifrågor och själva etableringsprocessen, speciellt i Latinamerika men även i Spanien och Portugal. Resultat: Det visade sig att ett litet, teknikbaserat företags inställning till internationalisering inte påverkades av dess litenhet och begränsade ekonomiska resurser. Företagets storlek påverkar inte snabbheten i internationaliseringsprocessen. Snabbheten berodde främst på företagets interna resurser i form av humankapital och organisatoriska resurser samt ledningens entreprenörskap. Liten hemmamarknad, starkt nischad och standard produkt samt viljan att etablera sig över hela världen var några av orsakerna till denna typ av företags internationalisering. Ett litet industriföretag kan uppnå en snabb internationaliseringsprocess om ledningen har bred erfarenhet i internationell marknadsföring. Roxtecs ledning hade erfarenhet när det gällde marknader som var psykiskt avlägsna, dessa utvecklades med hjälp av personer som kunde språk, affärskultur, samt hade marknadskännedom och kontakter.I Spanien, Portugal och Latinamerika använde Roxtec flera marknadskanaler samtidigt för att få en större marknadstäckning. Ett litet tillverkningsföretag med begränsade finansiella resurser behöver få lönsamhet så snabbt som möjligt för att kunna finansiera sin internationaliseringsprocess.

Syftet med studien är att undersöka vilken affärsmodell som born globals använder vid internationalisering och vilka faktorer som påverkar valet av modell. Studien har använt sig av en kvalitativ forskningsmetod och har genomförts som en fallstudie. Vidare utgörs studien av semistrukturerade intervjuer. Studien kommer fram till att born globals vid internationalisering har en affärsmodell som är freemium och att det resursbaserade synsättet samt bransch är viktiga bakomliggande faktorer till valet av affärsmodell. Faktorerna globalisering och entrepenören har mindre direkt påverkan medan nätverk endast har en begränsad påverkan i valet av affärsmodell för born globals vid internationalisering. / The purpose of this study is to examine the business model that Born Globals use during their internationalization, and the factors that influence the choice of model. The study has used a qualitative research method and has been implemented as a case study. Furthermore, the study consists of semi-structured interviews. The study concluded that the internationalization of born globals has a freemium business model, and that the resource-based approach, and industry are important factors behind the choice of business model. Less direct impact has globalization and entrepreneur while networks have only a limited impact on the choice of business model for internationalization of born globals.

Unemployment amongst Swedish citizens is higher within the group which falls under the designation foreign-born. The aim of this thesis is to examine which municipal factors that can explain the differences in unemployment amongst foreign-born relative to native born.The empirical models are examined with both cross-sectional data for the year of 2010 and panel data for the years of 2002-2012. The examination is implemented through a linear regression analysis of the type Ordinary Least Squares (OLS) and Fixed Effect regressions. A theory section will be presented where the theory on Non-Accelerating Inflation Rate (NAIRU), theories on discrimination and country-specific human capital are illustrated. The result from the cross-sectional data shows that the amount of foreign-born, the level of foreign-born immigrated from Nordic countries have a significant negative effect on unemployment amongst foreign-born. The general unemployment shows a significant positive effect on the unemployment amongst foreign-born. The result from the panel data however shows that the acceptance rate in Swedish for immigrants (SFI) and the highest level for tertiary education also have a significant negative effect on unemployment amongst foreign born. According to the theory of country-specific human capital, an increase in languageskills and education will increase the individual’s human capital and productivity, hencedecrease unemployment amongst foreign-born. This theory also indicates that an increase in the level of foreign-born immigrated from Nordic countries has a lower “cultural distance”,hence easier to integrate into the Swedish labor market. Previous research indicates that an increase of the amount of foreign-born can decrease the unemployment amongst this group through an expansion of social network and employer contacts. According to the theory of NAIRU, the level of equilibrium unemployment is affected by changes in the composition ofthe workforce, hence should affect the unemployment amongst foreign-born in the corresponding direction. This indicates that the integration policy is of importance to bring down the level of NAIRU. / Arbetslöshet är ett omtalat fenomen inom den svenska samhällsdebatten. Arbetslösheten bland Sveriges invånare är högre bland den grupp människor som faller under beteckningen utrikes födda. Syftet med denna uppsats är att undersöka vilka kommunala faktorer som kan förklara skillnaden i arbetslöshet mellan utrikes- och inrikes födda. De empiriska modellerna testas både med tvärsnittsdata för år 2010 samt paneldata för år 2002-2012. Undersökningen genomförs med en linjär regressionsanalys av typen Ordinary Least Squares (OLS) samt Fixed Effect regressioner. Datamaterialet är av sekundär data från Statistiska centralbyrån(SCB). Ett teoriavsnitt kommer att presenteras där teorin om Non-Accelerating Inflation Rate of Unemployment (NAIRU) samt teorier om diskriminering och land-specifikt humankapital belyses. Resultatet av tvärsnittsdata visar att andelen utrikes födda, andelen invandrade från Norden har en signifikant negativ effekt på arbetslöshet bland utrikes födda samt att den allmänna arbetslösheten har en signifikant positiv effekt på arbetslöshet bland utrikes födda. Resultatet av paneldata visar att även andelen godkända i svenska för i invandrare samt högstaeftergymnasiala utbildningsnivå har en signifikant negativ effekt på arbetslöshet bland utrikesfödda. Enligt teorin om land-specifikt humankapital ökar språkkunskaper samt utbildning individens humankapital och således produktivitet vilket minskar arbetslösheten bland utrikesfödda. Denna teori belyser även att andelen invandrade från Norden har ett lägre ”kulturavstånd” och bör således ha lättare att integrera sig på den svenska marknaden. Detta medför att arbetslöshet bland utrikes födda reduceras. Tidigare forskning tyder på att ökad andel utrikes födda kan minska arbetslöshet bland denna grupp genom ökat socialt nätverkoch arbetsgivarkontakter. Enligt teorin om NAIRU, påverkas jämviktsarbetslösheten av förändringar i arbetskraftens sammansättningar vilket bör medföra en påverkan på arbetslöshet bland utrikes födda i motsvarande riktning. Detta indikerar att integrationspolitiken är av betydelse för att få ner nivån på NAIRU.

Ce travail est destiné au développement de méthodes approchées de chimie quantique capables de traiter des systèmes biologiques de grande taille. En particulier, nous réalisons des simulations de dynamique moléculaire dans l'approximation de Born-Oppenheimer, permettant une description quantique de l'Hamiltonien électronique du système dans son entier : SEBOMD (SemiEmpirical Born-Oppenheimer Molecular Dynamics). Notre approche se base sur un Hamiltonien électronique semiempirique (SE). L'une des principales difficultés rencontrées lors d'une simulation SEBOMD de la phase condensée est représentée par le choix de la méthode SE. La plupart des méthodes courantes ne permettant pas une bonne description de certaines interactions fondamentales, nous avons développé une nouvelle approche. Cette méthode, dénommée PM3-PIF3, a été appliquée à l'étude par dynamique moléculaire de molécules organiques dans l'eau. Les résultats obtenus montrent que notre méthode est appropriée pour le traitement de molécules comportant des groupements hydrophobes et/ou hydrophiles en milieu aqueux. L'analyse des propriétés électroniques et vibrationnelles de ces molécules en présence du solvant valide également nos résultats vis-À-Vis d'autres études expérimentales et théoriques présentes dans la littérature. Finalement, nous nous sommes intéressés au processus d'autoprotolyse de l'eau en milieux confinés. Après avoir discuté du choix de l'Hamiltonien SE à utiliser pour cette étude, nous avons caractérisé le transfert de proton dans un agrégat d'eau. Nous avons établi une corrélation entre l'énergie libre associée à la première étape de ce transfert et certaines propriétés physiques collectives / The present work is devoted to the development of approximate quantum chemistry methods that are suitable to treat biological systems of large size. In particular, we run molecular dynamics under the Born-Oppenheimer approximation, allowing a quantum mechanical description of the electronic Hamiltonian of the full system: SEBOMD (SemiEmpirical Born-Oppenheimer Molecular Dynamics). Our method is based on a semiempirical (SE) electronic Hamiltonian. One of the key issues arising in a condensed phase SEBOMD simulation is represented by the choice of the SE method. Since most of the currently available approaches fail in describing some relevant intermolecular interactions, we developed a new correction of SE Hamiltonians. This method, which we named PM3-PIF3, was applied to study the molecular dynamics of organic molecules in water. The results that we obtained showed that our technique is suitable to treat molecules having hydrophobic and/or hydrophilic groups in an aqueous medium. The analysis of the electronic and vibrational properties of these molecules in the presence of the solvent validates our results with respect to experimental and theoretical studies in the literature. Finally, we investigated the water self-Dissociation process in confined environments. After discussing the choice of the SE Hamiltonian to be used for this purpose, we characterized the proton transfer in a water cluster. We established a correlation between the free energy of the first step of this process and some collective physical properties