Submitted by Caroline Xavier (caroline.xavier@pucrs.br) on 2017-06-30T18:25:54Z No. of bitstreams: 1 DIS_LIVIA_NORA_BRANDALISE_PARCIAL.pdf: 6570989 bytes, checksum: b62ad256dd548bf41239e556f8d77cc1 (MD5) / Approved for entry into archive by Caroline Xavier (caroline.xavier@pucrs.br) on 2017-06-30T18:26:01Z (GMT) No. of bitstreams: 1 DIS_LIVIA_NORA_BRANDALISE_PARCIAL.pdf: 6570989 bytes, checksum: b62ad256dd548bf41239e556f8d77cc1 (MD5) / Made available in DSpace on 2017-06-30T18:26:08Z (GMT). No. of bitstreams: 1 DIS_LIVIA_NORA_BRANDALISE_PARCIAL.pdf: 6570989 bytes, checksum: b62ad256dd548bf41239e556f8d77cc1 (MD5) Previous issue date: 2017-03-20 / Background: Personality traits are an important construct in the study of obesity, both to understand its influence on this condition?s origins and to evaluate its role in responses to treatments, such as bariatric surgery. The main models used so far, are based on dimensions of normal personality traits, bringing conflicting results. Hence, there is a demand for instruments that can give more accuracy and improve the study of the personality in this population capturing more dysfunctional traits. In a special section for emerging measures, the new edition of the Diagnostic Statistical Manual of Psychiatric Disorders (DSM-5) proposed an instrument to measure personality mal-adaptive traits: the Personality Inventory for DSM-5 (PID-5), whose psychometric properties have been tested in several samples and localities. Despite promising results, PID-5 has not yet been evaluated psychometrically in other clinical populations where the "personality" construct can have an important impact (in etiologic and prognostic ways), such as obese candidates for bariatric surgery. Objective: The aim of this study is to investigate the psychometric properties of the PID-5 in the evaluation of pathological personality traits in obese candidates for bariatric surgery. This constitutes a fundamental step to assess whether the instrument keeps its original technical features allowing its use and correct interpretation in this population. Setting: Centro da Obesidade e S?ndrome Metab?lica, Pontif?cia Universidade Cat?lica do Rio Grande do Sul (COM-PUCRS), Porto Alegre, Brazil Methods: Cross-sectional study involving 312 medical records of patients who applied for bariatric surgery. We collected demographic data and scores from instruments applied in the psychiatric evaluation routine. The reliability of facets and domains was evaluated through internal consistency indices and the unidimensionality of facets was verified through factorial methods. Exploratory Structural Equations Modeling was performed to test the higher order structure of the model. To investigate convergent validity, linear correlations were calculated between PID-5 scales and instrument scores of correlated constructs (depression, anxiety, defensive styles, and quality of life). Given the characteristic of the sample, we also correlated PID-5 with body mass index (BMI) and binge eating symptoms. Data was analyzed by Factor and Mplus softwares. Results: Facets were unidimensional, with the exception of Risk Taking, better explained by two factors. We replicate the higher order structure of 5 factors of the original model, with good congruence coefficients. The internal consistency of the domains was satisfactory, however, some facets showed fragility of internal consistency, mainly when calculated with more robust methods. In general, the domains and facets correlated as expected with correlated constructs. Conclusion: This study found evidences of adequate psychometric properties of PID-5 for a sample of obese candidates for bariatric surgery. Our results indicate that the instrument is appropriate to be applied in this population, consistently evaluating personality domains and facets of the DSM-5 model. More studies in other centers are needed to replicate and reinforce our findings. / Introdu??o: Tra?os de personalidade s?o um construto importante no estudo da obesidade, tanto para entender sua influ?ncia na g?nese desta condi??o, quanto para avaliar o papel que desempenham nas respostas aos tratamentos, como a cirurgia bari?trica. At? o momento, os principais instrumentos utilizados para o estudo desta rela??o baseiam-se em modelos que avaliam dimens?es de tra?os normais da personalidade, trazendo resultados conflitantes. Existe portanto, uma demanda por instrumentos que possam fornecer maior acur?cia e aperfei?oar o estudo da personalidade nesta popula??o, captando tra?os mais disfuncionais. Em uma se??o especial para medidas emergentes, a nova edi??o do Manual Estat?stico Diagn?stico dos Transtornos Psiqui?tricos (DSM-5) prop?s um instrumento para mensurar tra?os mal-adaptativos de personalidade: o Personality Inventory for DSM-5 (PID-5), cujas propriedades psicom?tricas vem sendo testadas em diversas amostras e localidades. A despeito de promissores resultados, o PID-5 ainda n?o foi avaliado psicometricamente em outras popula??es cl?nicas onde o construto ?personalidade? pode ter um impacto importante (em termos etiol?gicos e progn?sticos), como a constitu?da por obesos candidatos a cirurgia bari?trica. Objetivo: Investigar as propriedades psicom?tricas do PID-5 na avalia??o dos tra?os patol?gicos de personalidade em pacientes obesos candidatos a cirurgia bari?trica. Esta ? uma etapa metodol?gica fundamental para verificar se o instrumento mant?m suas caracter?sticas t?cnicas originais viabilizando seu uso e correta interpreta??o nesta popula??o. Local: Centro da Obesidade e S?ndrome Metab?lica, Pontif?cia Universidade Cat?lica do Rio Grande do Sul (COM-PUCRS), Porto Alegre, Brasil M?todos: Estudo transversal envolvendo 312 prontu?rios de pacientes candidatos a cirurgia bari?trica. Foram coletados dados demogr?ficos e escores de instrumentos aplicados na rotina de avalia??o psiqui?trica pr?-operat?ria. A fidedignidade das facetas e dom?nios do PID-5 foi avaliada atrav?s de ?ndices de consist?ncia interna e a unidimensionalidade das facetas atrav?s de m?todos fatoriais. O teste da estrutura de ordem superior foi realizado por meio do Modelagem de Equa??es Estruturais Explorat?rias. Para investigar a validade convergente, foram calculadas correla??es lineares entre as escalas do PID-5 e os escores de instrumentos de construtos correlatos (depress?o, ansiedade, estilos defensivos e qualidade de vida). Dada a caracter?stica da amostra, tamb?m correlacionamos o instrumento com o ?ndice de massa corporal (IMC) e sintomas compulsivos alimentares. Os dados foram analisados pelos softwares Factor e Mplus. Resultados: As facetas de personalidade apresentaram-se de forma unidimensional, ? ?nica exce??o de Exposi??o a Riscos, melhor explicada por dois fatores. Replicamos a estrutura de ordem superior de 5 fatores do modelo original, com bons coeficientes de congru?ncia. A consist?ncia interna dos dom?nios foi satisfat?ria, entretanto algumas facetas demonstraram fragilidades de consist?ncia interna, sobretudo calculados com m?todos mais robustos. De forma geral, os dom?nios e facetas correlacionaram-se de forma esperada com os construtos correlatos. Conclus?o: Este estudo encontrou evid?ncias de propriedades psicom?tricas adequadas do PID-5 para uma amostra de obesos graves candidatos a cirurgia bari?trica. Nossos resultados indicam que o instrumento ? apropriado para ser aplicado nesta popula??o, avaliando coerentemente os dom?nios e facetas da personalidade do modelo DSM-5. Mais estudos em outros centros s?o necess?rios para replicar e refor?ar nossos achado.

Submitted by Caroline Xavier (caroline.xavier@pucrs.br) on 2017-06-30T18:27:46Z No. of bitstreams: 1 TES_EDNA_THAIS_JEREMIAS_MARTINS_PARCIAL.pdf: 836849 bytes, checksum: 33e168f477805280676d4d2bea60a938 (MD5) / Approved for entry into archive by Caroline Xavier (caroline.xavier@pucrs.br) on 2017-06-30T18:27:54Z (GMT) No. of bitstreams: 1 TES_EDNA_THAIS_JEREMIAS_MARTINS_PARCIAL.pdf: 836849 bytes, checksum: 33e168f477805280676d4d2bea60a938 (MD5) / Made available in DSpace on 2017-06-30T18:28:01Z (GMT). No. of bitstreams: 1 TES_EDNA_THAIS_JEREMIAS_MARTINS_PARCIAL.pdf: 836849 bytes, checksum: 33e168f477805280676d4d2bea60a938 (MD5) Previous issue date: 2016-12-13 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior - CAPES / Introduction: Weight gain is a major concern in patients seeking smoking cessation, being an important barrier for both starting an attempt to stop smoking and maintaining long abstinence. Objective: To evaluate the weight changes after 12 months of smoking abstinence. We also intended to identify risk factors for weight changes. Methods: This study was conducted at the Smoking Cessation Clinic, Hospital S?o Lucas, in Porto Alegre, Brazil, from June 2007 to June 2016. In a real life cohort design, smokers submitted to cognitive-behavior therapy and pharmacotherapies for smoking cessation were included. The baseline and final weights were measured and the smoking cessation was confirmed by exhaled CO <10ppm and patient's confirmation of being abstinent. Results: From the 348 included volunteers, 187(53.7%) subjects failed to stop smoking but 161 patients quit smoking and maintained abstinence for 12 months. Regarding weight change, 104(64.6%) subjects maintained their initial weight or had a shift up or down of less than 5%. Another group increased their weight more than 5% (n=57; 35.4%). Only 18 patients (11.2%) increased >10% of their initial weight. We detected no risk factor associated with weight increase greater than 5%. The number needed to harm associated to smoking cessation was 3.4(95%CI 2.6-5.2). Conclusion: Our results show that weight gain not necessarily associates to smoking cessation and a high percentage of quitters maintain or even lose weight. This information may be useful to address to the still undecided smoker concerned about possible weight gain. This strategy will be probably useful in every level of clinical attendance, but especially in Primary Care Units. / Introdu??o: O ganho de peso ? uma grande preocupa??o para os pacientes que tentam parar de fumar, tornando-se uma barreira tanto para iniciar uma tentativa de cessa??o quanto para manter a abstin?ncia em longo prazo. No entanto, alguns dos que conseguem manter-se em abstin?ncia n?o engordam e outros at? perdem algum peso. Objetivo: Avaliar as altera??es de peso ap?s 12 meses de abstin?ncia tab?gica confirmada. Tamb?m pretende-se identificar fatores de risco para ganho de peso. M?todos: Foi realizado estudo de coorte no Ambulat?rio de Cessa??o do Tabagismo, Hospital S?o Lucas, em Porto Alegre, Brasil, de junho de 2007 a junho de 2016 nos pacientes que buscaram ajuda para cessa??o do tabagismo. Foram inclu?dos fumantes submetidos ? terapia cognitivocomportamental combinada com farmacoterapia para cessa??o tab?gica. O peso no in?cio e no final foi registrado e a cessa??o do tabagismo foi confirmada pelo COex <10ppm e pela confirma??o dos pacientes de serem abstinentes. Resultados: Foram inclu?dos 348 volunt?rios no estudo, dos quais, 187(53,7%) falharam em cessar o tabagismo, mas 161 (46,3%) pacientes conseguiram manter abstin?ncia de no m?nimo 12 meses. Em rela??o ? altera??o ponderal, 104(64,6%) ex-fumantes mantiveram o peso ou apresentaram altera??o para mais ou para menos de at? 5% do peso inicial. Outro grupo teve aumento de peso maior de 5% (n=57; 35.4%). Apenas 18 (11,2%) pacientes aumentaram mais de 10% de seu peso inicial. N?o foi detectado nenhum fator de risco com signific?ncia estat?stica associado com aumento de peso maior que 5%. O n?mero necess?rio para causar dano (NNH) associado ? cessa??o tab?gica foi 3.4 (IC 95% 2,6-5,2). Conclus?o: Estes resultados mostram que o ganho de peso n?o est? necessariamente associado ? cessa??o do tabagismo e que um percentual n?o negligenci?vel de ex-fumantes mant?m ou mesmo perde peso ao parar de fumar. Esta informa??o pode ser ?til para o fumante ainda indeciso por estar preocupado com o poss?vel ganho de peso. Esta estrat?gia ser? provavelmente ?til em todos os n?veis de atendimento cl?nico, mas especialmente nas Unidades de Aten??o B?sica.

Submitted by Caroline Xavier (caroline.xavier@pucrs.br) on 2017-06-30T18:39:27Z No. of bitstreams: 1 DIS_LORENA_EVELYN_SILVA_CAVALCANTE_PARCIAL.pdf: 843706 bytes, checksum: 9e28b91e2d08f5204a5e3b2293c8a063 (MD5) / Approved for entry into archive by Caroline Xavier (caroline.xavier@pucrs.br) on 2017-06-30T18:39:35Z (GMT) No. of bitstreams: 1 DIS_LORENA_EVELYN_SILVA_CAVALCANTE_PARCIAL.pdf: 843706 bytes, checksum: 9e28b91e2d08f5204a5e3b2293c8a063 (MD5) / Made available in DSpace on 2017-06-30T18:39:41Z (GMT). No. of bitstreams: 1 DIS_LORENA_EVELYN_SILVA_CAVALCANTE_PARCIAL.pdf: 843706 bytes, checksum: 9e28b91e2d08f5204a5e3b2293c8a063 (MD5) Previous issue date: 2017-03-10 / Conselho Nacional de Pesquisa e Desenvolvimento Cient?fico e Tecnol?gico - CNPq / The insular cortex (IC) receives afferent projections from prefrontal cortex, cingulate gyrus, olfactory bulb, basal nuclei and forms reciprocal connections with important limbic areas: amygdala and entorhinal cortex. These different connections indicate a possible involvement of the insular cortex in the process of learning and memory. Social recognition memory (SRM) is essential for forming social groups, establishing hierarchies and social and affective ties. Despite its importance, the knowledge about the brain structures and the cellular and molecular mechanisms involved in its processing is still scarce. Thus, the present study aimed to verify the participation of NMDA-glutamatergic, D1/D5-dopaminergic, H2-histaminergic, ?-adrenergic and 5-HT1A serotoninergic receptors, of the IC, in the consolidation of SRM. For this, male Wistar adult rats (300-330 g) were submitted to stereotaxic surgery for implantation of bilateral cannulae in the IC and, later, to the task of social discrimination. The task consists of 4 consecutive days of habituation to the experimental apparatus, which is an open-field box containing 2 acrilic cilinders, for 20 min. Twenty four hours after the last habituation session, the animals were placed in the open field in the presence of a juvenile (22 days postnatal) for 1 hour (sample phase). After 24 hours, the retention test occurred, for 5 min, in the presence of a juvenile previously met (familiar) and a new juvenile. Animals that received the intra-IC infusion of the antagonist D1/D5, ?-adrenergic or 5-HT1A receptor, immediately after the sample phase, impairs the consolidation of SRM. However, this effect was blocked by the concomitant intra-IC infusion of the agonist and the antagonist of the respective receptors. In addition, animals that received intra-IC infusion of the antagonists NMDA and H2 receptors, immediately after the sample phase, were able to consolidate the SRM. The results obtained in the present study suggest that the dopaminergic D1/D5, ?-adrenergic and serotonergic 5-HT1A receptors, but not the glutamatergic NMDA and the histaminergic H2 receptors, of the IC, participates in the consolidation of the SRM. / O c?rtex insular (CI) recebe proje??es aferentes do c?rtex pr?-frontal, giro cingulado, bulbo olfat?rio, n?cleos da base, al?m de formar conex?es rec?procas com importantes ?reas l?mbicas: am?gdala e c?rtex entorrinal. Estas diferentes conex?es indicam um poss?vel envolvimento do c?rtex insular no processo de aprendizado e mem?ria. A mem?ria de reconhecimento social (MRS) ? essencial para formar grupos sociais, estabelecer hierarquias e v?nculos sociais e afetivos. Apesar de sua import?ncia, ainda ? escasso o conhecimento sobre o papel das estruturas cerebrais e os mecanismos celulares e moleculares envolvidos em seu processamento e armazenamento. Assim, o presente trabalho teve como objetivo verificar a participa??o dos receptores glutamat?rgicos do tipo NMDA, dopamin?rgicos D1/D5, histamin?rgico H2, ?-adren?rgico e serotonin?rgico 5-HT1A, do c?rtex insular, no processo de consolida??o da MRS. Para isso, ratos Wistar machos adultos foram submetidos a uma cirurgia estereot?xica para implanta??o de c?nulas bilaterais no CI e, posteriormente, ? tarefa de discrimina??o social. Esta tarefa consiste de 4 sess?es di?rias de 20 min de habitua??o ao aparato experimental, que ? constitu?do de uma caixa de campo aberto contendo dois cilindros de acr?lico. Vinte e quatro horas ap?s a ?ltima sess?o de habitua??o os animais foram recolocados no aparato, na presen?a de um coespec?fico juvenil (22 dias p?s-natal) dentro de um dos cilindros, por 1 hora (sess?o de treino). Ap?s 24 horas os animais foram submetidos a uma sess?o de teste, de 5 min, na presen?a de um juvenil desconhecido e do juvenil previamente encontrado (familiar). Verificou-se que, os animais que receberam a infus?o intra-CI do antagonista dos receptores D1/D5, ?-adren?rgico ou 5-HT1A imediatamente ap?s a sess?o de treino, tiveram um preju?zo na consolida??o da MRS. Contudo, esse efeito foi bloqueado pela infus?o intra-CI concomitante do agonista e do antagonista dos respectivos receptores. Ainda, os animais que receberam a infus?o intra-CI do antagonista dos receptores NMDA ou H2 imediatamente ap?s a sess?o de treino, foram capazes de consolidar a MRS. Os resultados obtidos no presente trabalho sugerem que os receptores dopamin?rgicos D1/D5, ?-adren?rgicos e serotonin?rgicos 5-HT1A, mas n?o os glutamat?rgicos NMDA e os histamin?rgicos H2, do c?rtex insular participam da consolida??o da MRS.

Submitted by Caroline Xavier (caroline.xavier@pucrs.br) on 2017-07-03T14:05:15Z No. of bitstreams: 1 DIS_CAROLINA_LUFT_PARCIAL.pdf: 1363434 bytes, checksum: d818669691f31ae3818b9580af4ca189 (MD5) / Approved for entry into archive by Caroline Xavier (caroline.xavier@pucrs.br) on 2017-07-03T14:05:24Z (GMT) No. of bitstreams: 1 DIS_CAROLINA_LUFT_PARCIAL.pdf: 1363434 bytes, checksum: d818669691f31ae3818b9580af4ca189 (MD5) / Made available in DSpace on 2017-07-03T14:05:32Z (GMT). No. of bitstreams: 1 DIS_CAROLINA_LUFT_PARCIAL.pdf: 1363434 bytes, checksum: d818669691f31ae3818b9580af4ca189 (MD5) Previous issue date: 2017-03-03 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior - CAPES / Conselho Nacional de Pesquisa e Desenvolvimento Cient?fico e Tecnol?gico - CNPq / INTRODUCTION: Potential threats to homeostasis may occur during the in utero period, promoting programming effects on both neurological development and hypothalamic-pituitary-adrenal (HPA) axis function. The HPA axis acts as a control and regulatory center of the body that connects the central nervous system to the hormonal system. The axis responds to the stressor stimulus and assists the body to maintain homeostasis, as well as being essential to the normal regulatory physiological functioning. Physically fit and physically active individuals exhibit a lower rate of health problems, especially when faced with stressful situations, contributing to reduced levels of anxiety and depression. OBJECTIVE: To evaluate the effects of physical exercise before the gestational period on changes due to prenatal stress in adult mice. METHODS: Balb/c female and male mice were divided into three groups: control (CTLE), prenatal restraint stress (PNS) and physical exercise before the gestational period and prenatal restraint stress (EX+PNS). The weight of the animals was evaluated during gestation, days 1, 10 and 21 of life and also as adults. Animals were then maintained until adulthood (60 days of life) when fear/anxiety behaviors were evaluated in the elevated plus maze, and depression was evaluated using the preference for sucrose and the ingestion of sucrose test. In addition, real-time PCR gene expression of corticotrophin releasing hormone (CRHR1) type 1 receptor in the prefrontal cortex, glucocorticoid receptor (GR) and mineralocorticoid (MR) receptor in the hippocampus, as well as plasmatic concentrations of corticosterone were evaluated. RESULTS: During gestation, females of the EX+PNS group presented greater weight in relation to the CTLE group. Regarding the offspring weight, animals of the EX+PNS group showed an increase in weight on days 1, 10 and 21 of life, compared to the PNS group. During the adult life, animals stressed in the prenatal period presented lower weight, while the pregestational exercise promoted an increase in the offspring weight in relation to the CTLE group. In relation to behavioral tests, there was a significant decrease in the time spent in the open arms of the elevated plus maze in the PNS and EX+PNS groups, in both sexes, demonstrating an increase in fear/anxiety behavior. Prenatal stress increased the preference for sucrose in females and sucrose intake in both sexes. However, exercise promoted a significant decrease in sucrose intake in males and females. CRHR1 expression decreased in the prefrontal cortex of EX+PNS females compared to the PNS group. On the other hand, pregestational exercise was not able to reverse the significant decrease in basal GR concentrations caused by prenatal stress in adult females. There were no significant differences between groups in GR gene expression in males, as well as in MR and corticosterone in both females and males. CONCLUSION: Physical exercise on the treadmill before the gestational period seems to be able to reduce the effects of prenatal stress on important markers of the HPA axis response in a sex-dependent manner. / INTRODU??O: Potenciais amea?as para a homeostasia podem ocorrer durante a vida in utero, promovendo efeitos de programa??o tanto no desenvolvimento neurol?gico quanto na fun??o do eixo hipot?lamo-pituit?ria-adrenal (HPA). O eixo HPA ? o centro controlador e regulador do organismo que conecta o sistema nervoso central com o sistema hormonal. Este eixo responde ao est?mulo estressor e auxilia o organismo a manter a homeostasia, al?m de ser essencial para auxiliar no funcionamento fisiol?gico normal. Indiv?duos fisicamente aptos e que praticam frequentemente atividades f?sicas exibem um menor ?ndice de problemas de sa?de, especialmente quando se deparam com situa??es de estresse, contribuindo na redu??o dos n?veis de ansiedade e depress?o. OBJETIVO: Avaliar os efeitos do exerc?cio f?sico antes do per?odo gestacional sobre altera??es decorrentes do estresse pr?-natal em camundongos adultos. METODOLOGIA: F?meas e machos Balb/c foram divididos em tr?s grupos: controle (CTLE), estresse pr?-natal por conten??o (PNS) e exerc?cio f?sico antes do per?odo gestacional e estresse pr?-natal por conten??o (EX+PNS). O peso dos animais foi avaliado durante a gesta??o, e nos dias 1, 10 e 21 de vida e na vida adulta. Esses animais foram mantidos at? a idade adulta (60 dias de vida) quando foram avaliados os comportamentos de medo/ansiedade, no aparato de labirinto em cruz elevada, e depress?o, por meio do teste de prefer?ncia e ingest?o de sacarose. Al?m disso, foi avaliada a express?o g?nica, atrav?s da t?cnica de PCR em tempo real, do receptor tipo 1 do horm?nio liberador de corticotrofina (CRHR1) no c?rtex pr?-frontal, do receptor de glicocorticoide (GR) e do receptor de mineralocorticoide (MR) no hipocampo e as concentra??es plasm?ticas de corticosterona foram avaliadas. RESULTADOS: Durante a gesta??o, as f?meas do grupo EX+PNS apresentaram maior peso em rela??o ao grupo CTLE. Em rela??o ao peso da prole, os animais do grupo EX+PNS exibiram um aumento no peso nos dias 1, 10 e 21 de vida, comparados com o grupo PNS. Durante a vida adulta, os animais estressados no per?odo pr?-natal apresentaram menor peso, enquanto o exerc?cio pr?-gestacional promoveu um aumento no peso da prole, em rela??o ao grupo CTLE. Em rela??o aos testes comportamentais, houve uma diminui??o significativa no tempo gasto no bra?o aberto do aparato de labirinto em cruz elevada nos animais dos grupos PNS e EX+PNS, em ambos os sexos, demonstrando um aumento no comportamento de medo/ansiedade. O estresse pr?-natal aumentou a prefer?ncia por sacarose em f?meas e a ingest?o de sacarose em ambos os sexos. No entanto, o exerc?cio promoveu uma diminui??o significativa na ingest?o de sacarose, em machos e f?meas. A express?o de CRHR1 diminuiu no c?rtex pr?-frontal de f?meas do grupo EX+PNS em rela??o ao grupo PNS. Por outro lado, o exerc?cio antes da gesta??o n?o foi capaz de reverter a diminui??o significativa nas concentra??es basais de GR provocadas pelo estresse pr?-natal em f?meas adultas. N?o houve diferen?as significativas entre os grupos na express?o g?nica de GR em machos e de MR e corticosterona em f?meas e machos. CONCLUS?O: O exerc?cio f?sico em esteira antes do per?odo gestacional parece ser capaz de reduzir os efeitos do estresse pr?-natal em marcadores importantes da resposta do eixo HPA de uma maneira dependente do sexo.

Submitted by Caroline Xavier (caroline.xavier@pucrs.br) on 2017-07-04T13:04:54Z No. of bitstreams: 1 DIS_PAULA_ROSALES_ZUBIAURRE_PARCIAL.pdf: 543543 bytes, checksum: 6d5071c3ac2beb85a152586328ec9cea (MD5) / Approved for entry into archive by Caroline Xavier (caroline.xavier@pucrs.br) on 2017-07-04T13:05:03Z (GMT) No. of bitstreams: 1 DIS_PAULA_ROSALES_ZUBIAURRE_PARCIAL.pdf: 543543 bytes, checksum: 6d5071c3ac2beb85a152586328ec9cea (MD5) / Made available in DSpace on 2017-07-04T13:05:14Z (GMT). No. of bitstreams: 1 DIS_PAULA_ROSALES_ZUBIAURRE_PARCIAL.pdf: 543543 bytes, checksum: 6d5071c3ac2beb85a152586328ec9cea (MD5) Previous issue date: 2017-03-10 / Introduction: The prevalence of obesity has tripled in the last four decades in the world, from 4.8% in 1975 to 12.8% in 2014. In Brazil, there was an increase of 6.3% in the prevalence of obesity from 2006 to 2014. The Brazilian Unified Health System had an annual cost of US$ 2.1 billion with outpatient procedures and hospitalizations. Ten percent of this cost was exclusively spent to treat obesity. The aim of this study was to compare the costs of medical and surgical treatment of severe obesity at centers of excellence for the treatment of obesity funded by the Brazilian Unified Health System. We also intended to estimate the direct and indirect costs. Methods: We conducted an observational, population-based, multicenter study estimating the costs and loss of productivity during 12 months related to obese patients treated at public centers of excellence for obesity. Results: Our sample included 274 patients, 140 patients were allocated to the surgical group and 134 patients were in medical group, with a female predominance in both groups. The surgical group had a higher morbidity rate than the medical group. The surgical group had a lower direct cost (Int$ 1,671.38 vs. Int$ 1,763.71). Three years after the surgery, the indirect cost of medical treatment was higher than the surgical treatment. Conclusion: This study showed that the total costs were higher in the surgical group in the first 2 years after surgery; however, from the third year on there was a significant decrease in costs, reaching lower costs than the medical group. Around 80% of the population studied in the female gender, which reflects a worldwide reality of gender distribution. Indirect costs, which reflect obesity impacts on the labor market, accounted for around 20% of total costs. / Introdu??o: A preval?ncia de obesidade triplicou nas ?ltimas quatro d?cadas em termos mundiais, passando de 4,8% em 1975 para 12,8% em 2014. No Brasil houve um incremento de 6,3% na preval?ncia de obesidade de 2006 para 2014. O sistema p?blico de sa?de brasileiro demonstrou um custo anual com procedimentos ambulatoriais e hospitaliza??es de US$2,1 bilh?es, dado que 10% seria a fra??o atribu?vel exclusivamente ? obesidade. O objetivo do presente estudo foi comparar os custos do tratamento cl?nico e cir?rgico da obesidade grave em centros de refer?ncia para o tratamento da obesidade do Sistema ?nico de Sa?de Brasileiro e estimar os custos diretos e indiretos. M?todos: Estudo observacional, de base populacional, multic?ntrico, que estimou a utiliza??o de recursos de sa?de e a perda de produtividade no per?odo de 12 meses de indiv?duos obesos em acompanhamento em centros de refer?ncia para o tratamento da obesidade no SUS. Resultados: Foi inclu?do um total de 274 pacientes, sendo 140 pacientes no grupo cir?rgico e 134 pacientes no grupo cl?nico, com predom?nio do sexo feminino em ambos os grupos. Mostrou-se que o grupo cir?rgico possui uma carga de morbidade maior que o grupo cl?nico. O grupo cir?rgico apresentou um custo direto menor (R$ 2.785,64 versus R$ 2.939,70). Ap?s o terceiro ano de p?s-operat?rio o custo indireto do tratamento cl?nico j? ? superior ao tratamento cir?rgico. Conclus?o: O presente estudo evidenciou que os custos totais foram maiores no grupo cir?rgico nos primeiros 2 anos de p?s-operat?rio, por?m a partir do terceiro ano houve uma diminui??o significativa, atingindo n?veis inferiores ao do grupo cl?nico. Em torno de 80% da popula??o estudada ? do g?nero feminino, o que reflete a realidade mundial da distribui??o de g?neros. Os custos indiretos, que refletem impactos da obesidade no mercado de trabalho, representaram em torno de 20% dos custos totais.

Submitted by Caroline Xavier (caroline.xavier@pucrs.br) on 2017-07-04T13:40:39Z No. of bitstreams: 1 DIS_VERONICA_JOCASTA_CASAROTTO_PARCIAL.pdf: 1185142 bytes, checksum: 4a97fd7d94d929bdf5e964947d8da152 (MD5) / Approved for entry into archive by Caroline Xavier (caroline.xavier@pucrs.br) on 2017-07-04T13:40:52Z (GMT) No. of bitstreams: 1 DIS_VERONICA_JOCASTA_CASAROTTO_PARCIAL.pdf: 1185142 bytes, checksum: 4a97fd7d94d929bdf5e964947d8da152 (MD5) / Made available in DSpace on 2017-07-04T13:41:03Z (GMT). No. of bitstreams: 1 DIS_VERONICA_JOCASTA_CASAROTTO_PARCIAL.pdf: 1185142 bytes, checksum: 4a97fd7d94d929bdf5e964947d8da152 (MD5) Previous issue date: 2017-03-22 / Conselho Nacional de Pesquisa e Desenvolvimento Cient?fico e Tecnol?gico - CNPq / Aging is defined as a dynamic and progressive process, characterized by physiological, biochemical, psychological and others. This research aims to analyze the relationship between physical activity, the depressive symptoms and the ageing self-perception in elderly women socially active in Porto Alegre City/RS. This is a cross-sectional study. The instruments used were: General Survey (HQ), Geriatric Depression Scale (GDS), Self-perception of aging questionnaire (APQ) and international physical activity Questionnaire (IPAQ). The study had approval of the Scientific Committee and the Research Ethics Committee of the Institute of Geriatrics and Gerontology of PUCRS (CAAE: CEP 52097115.8.0000.5336-PUC-RS), and all the participants signed an informed consent. The statistical analyses used average, standard deviation, median, Kolmogorov-Smirnov test, analysis of variance (ANOVA), Tukey test, Kruskal-Wallis test, Pearson's Chi-square test and Spearman correlation. The significance level adopted was 5% (p < 0.05), and the analyses were performed in the version 21.0 of SPSS program. The results present a sample composed of 167 elderly women, at an average age of 70.0 (? 7.3), being the minimum age 60 and maximum 95. The age groups were divided into three groups, with the 60 to 69 year- old Group of (n = 91 54.5%), followed by the 70 to 79 year- old Group of (n = 54 32.3%) and the last group at the age of 80 or older (n = 22 13.2%). Regarding the schooling level, the incomplete elementary prevailed with 34.7% (n = 58), and complete high school with 31.7% (n = 53). On the civil status, the majority (68.3% n = 114) were declared as divorced, single or widowed. The four most prevalent diseases in the sample were, respectively, hypertension (68.9% n = 115), diabetes mellitus (17.4%, n = 29), osteoporosis (16.2% n = 27) and Dyslipidemia (15.6%, n = 26). The APQ, the positive control and positive consequence subscales presented the highest averages in the whole sample. On the scale of depression, 22.2% (n = 37) of the elderly women showed depressive symptomatology. However, this prevalence had no relationship with the age group (p = 0.693). The IPAQ questionnaire, the domain which has the greatest number of elderly women practicing more than 150 minutes a week, is the household chores (85.6% n = 143). Significant inverse associations were the physical activity practice on issues related to the work of the IPAQ with the scores of negative consequences and negative control of APQ; another relationship of physical activity with the means of transport of the IPAQ, with scores of negative control of the APQ and scores of depressive symptoms of GDS; and the association of physical activity in leisure-related issues with the scores of negative consequence of the APQ and depressive symptoms of the GDS. / O envelhecimento ? definido como um processo din?mico e progressivo, caracterizado por altera??es fisiol?gicas, bioqu?micas, psicol?gicas, dentre outras. O objetivo desta pesquisa ? analisar a rela??o entre a atividade f?sica, a sintomatologia depressiva e a autopercep??o do envelhecimento em idosas socialmente ativas do munic?pio de Porto Alegre/RS. Trata-se de um estudo transversal. Os instrumentos utilizados foram: Question?rio Geral (QG), Escala Geri?trica de Depress?o (GDS), Question?rio de Autopercep??o do Envelhecimento (APQ) e Question?rio Internacional de Atividade F?sica (IPAQ). O estudo teve aprova??o da Comiss?o Cient?fica e do Comit? de ?tica em Pesquisa do Instituto de Geriatria e Gerontologia da PUCRS (CAAE: 52097115.8.0000.5336 do CEP-PUC-RS), e todos os participantes assinaram o Termo de Consentimento Livre e Esclarecido. As an?lises estat?sticas utilizaram m?dia, desvio padr?o, mediana, teste de Kolmogorov-Smirnov, an?lise de vari?ncia (ANOVA), teste de Tukey, teste de Kruskal-Wallis, teste qui-quadrado de Pearson e correla??o de Spearman. O n?vel de signific?ncia adotado foi de 5% (p<0,05), e as an?lises foram realizadas no programa SPSS vers?o 21.0. Os resultados apresentam uma amostra composta por 167 idosas, com m?dia de idade de 70,0 (? 7,3) anos, sendo a idade m?nima 60 anos e a m?xima 95 anos. As faixas et?rias foram divididas em tr?s grupos, predominando o grupo de 60 a 69 anos (n=91? 54,5%), seguido do grupo de 70 a 79 anos (n=54? 32,3%) e o ?ltimo grupo de 80 anos ou mais (n=22? 13,2%). Em rela??o ao n?vel de escolaridade, prevaleceram o Ensino Fundamental incompleto, com 34,7% (n=58), e Ensino M?dio completo, com 31,7% (n=53). Sobre o estado civil, a maioria (68,3%? n=114) se declara separado, solteiro ou vi?vo. As quatro doen?as mais prevalentes na amostra foram, respectivamente, hipertens?o (68,9%? n=115), diabetes melito (17,4%? n=29), osteoporose (16,2%? n=27) e dislipidemia (15,6%? n=26). A APQ, as subescalas controle positivo e consequ?ncia positiva apresentaram as maiores m?dias na amostra total. Na escala de depress?o, 22,2% (n=37) das idosas apresentaram sintomatologia depressiva. No entanto, essa preval?ncia n?o teve rela??o com a faixa et?ria (p=0,693). No question?rio IPAQ, o dom?nio que possui mais idosas praticando mais de 150 min./sem. ? o de tarefas dom?sticas (85,6%? n=143). As associa??es significativas inversas foram a pr?tica de atividade f?sica nas quest?es relacionadas ao trabalho do IPAQ com os escores de consequ?ncia negativa e controle negativo da APQ; outra rela??o foi da atividade f?sica com o meio de transporte do IPAQ, com os escores de controle negativo da APQ e os escores de sintomas depressivos da GDS; e a associa??o da pr?tica de atividade f?sica nas quest?es relacionadas ao lazer com os escores de consequ?ncia negativa da APQ e os sintomas depressivos do GDS.

Submitted by PPG Gerontologia Biom?dica (geronbio@pucrs.br) on 2017-07-11T14:20:34Z No. of bitstreams: 1 LUFIEGO_CLAUDIA_ ADRIANA_ FACCO_ TESE.pdf: 1697607 bytes, checksum: 2c33c844db30bf8a9cb9a7315dba9439 (MD5) / Approved for entry into archive by Caroline Xavier (caroline.xavier@pucrs.br) on 2017-07-12T19:35:13Z (GMT) No. of bitstreams: 1 LUFIEGO_CLAUDIA_ ADRIANA_ FACCO_ TESE.pdf: 1697607 bytes, checksum: 2c33c844db30bf8a9cb9a7315dba9439 (MD5) / Made available in DSpace on 2017-07-12T19:40:47Z (GMT). No. of bitstreams: 1 LUFIEGO_CLAUDIA_ ADRIANA_ FACCO_ TESE.pdf: 1697607 bytes, checksum: 2c33c844db30bf8a9cb9a7315dba9439 (MD5) Previous issue date: 2017-03-31 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior - CAPES / To evaluate the efficacy of the guided imaging relaxation technique in cancer patients submitted to chemotherapy in relation to decreasing levels of depression, anxiety and stress. Methods: Non-randomized clinical trial type study. The sample consisted of participants of both sexes, and aged 30 years or more starting chemotherapy treatment in a university hospital in Porto Alegre. The patients were divided into two groups: Experimental Group, in which the relaxation technique was applied, and Control Group, without the intervention. The relaxation sessions with the guided imaging technique had a duration of 12 minutes and were performed during a period of 16 weeks, always during the chemotherapy procedure. In order to evaluate the levels of depression, anxiety and stress were applied the instruments Beck Depression Inventory, Beck Anxiety Inventory and Distress Thermometer respectively, in the initial and final period of the study. Data were analyzed in the EpiInfo7.0 statistical software using Student's t-tests, Wilcoxon-Mann-Whitney and Pearson's Chi-square. Values of p <0.05 were considered significant. Results: Onehundred thirteen participants were included, with a mean age of 51.3 years, 62.8% were female and 72.6% married. The most prevalent types of neoplasia were breast, lung and intestine cancers. Fifty-seven patients participated in the Experimental Group and 56 patients in the Control Group. There was a decrease in depression, anxiety and stress levels in the Experimental Group, with a range of depression scores ranging from 17.3 ? 9.04 to 14.5 ? 7.47 (p<0.0001), anxiety of 15.1 ? 8.84 to 12.9 ? 7.58 (p<0.0001) and for stress 5.1228 ? 1.8905 for 4.4386 ? 1.6905 (p<0.0001). In the Control Group, no significant difference was observed between the initial and final evaluation. Conclusions: the intervention through the relaxation technique with guided imagery showed efficacy in reducing the levels of depression, anxiety and stress in this sample of cancer patients undergoing chemotherapy. / avaliar a efic?cia da t?cnica de relaxamento com imagem guiada em pacientes oncol?gicos submetidos a tratamento quimioter?pico em rela??o ? diminui??o dos n?veis de depress?o, ansiedade e estresse. M?todos: Estudo do tipo ensaio cl?nico n?o randomizado. A amostra foi constitu?da de participantes de ambos os sexos, com idade igual ou superior a 30 anos e que estavam iniciando tratamento quimioter?pico em um hospital universit?rio de Porto Alegre. Os pacientes foram divididos em dois grupos: Grupo Experimental, no qual foi aplicada a t?cnica de relaxamento, e Grupo Controle, sem a interven??o. As sess?es de relaxamento com a t?cnica de imagem guiada tiveram dura??o de 12 minutos e foram realizadas durante um per?odo de 16 semanas, sempre durante o procedimento quimioter?pico. Para avaliar os n?veis de depress?o, ansiedade e estresse foram aplicados os instrumentos Invent?rio de Depress?o de Beck, Invent?rio de Ansiedade de Beck e Term?metro de Distress respectivamente, no per?odo inicial e final do estudo. Os dados foram analisados no software estat?stico EpiInfo7.0 utilizando os testes t de Student,Wilcoxon-Mann-Whitney e Qui-quadrado de Pearson. Foram considerados significativos valores de p<0,05. Resultados: Foram inclu?dos 113 participantes, com m?dia de idade de 51,3 anos, sendo 62,8% do sexo feminino e 72,6% casados. Os tipos de neoplasia mais prevalentes foram c?ncer de mama, pulm?o e intestino. Foram alocados 57 pacientes no Grupo Experimental e 56 pacientes no Grupo Controle. Houve diminui??o dos n?veis de depress?o, ansiedade e estresse nos pacientes do Grupo Experimental, com varia??o dos escores de depress?o de 17,3?9,04 para 14,5?7,47 (p<0,0001), de ansiedade de 15,1?8,84 para 12,9?7,58 (p<0,0001) e de estresse 5.1228?1.8905 para 4.4386?1.6905 (p<0,0001). No Grupo Controle n?o foi observada diferen?a significativa entre a avalia??o inicial e final. Conclus?es: A interven??o atrav?s da t?cnica de relaxamento com imagem guiada mostrou efic?cia em reduzir os n?veis dos sintomas de depress?o, ansiedade e estresse nesta amostra de pacientes oncol?gicos em vig?ncia de quimioterapia.

Submitted by Caroline Xavier (caroline.xavier@pucrs.br) on 2017-08-02T13:38:03Z No. of bitstreams: 1 DIS_SORAIA_LEMOS_DE_SIQUEIRA_COMPLETO.pdf: 1770308 bytes, checksum: 4220afcfa71b4f29b7880a79649bc375 (MD5) / Approved for entry into archive by Caroline Xavier (caroline.xavier@pucrs.br) on 2017-08-02T13:38:32Z (GMT) No. of bitstreams: 1 DIS_SORAIA_LEMOS_DE_SIQUEIRA_COMPLETO.pdf: 1770308 bytes, checksum: 4220afcfa71b4f29b7880a79649bc375 (MD5) / Made available in DSpace on 2017-08-02T13:39:14Z (GMT). No. of bitstreams: 1 DIS_SORAIA_LEMOS_DE_SIQUEIRA_COMPLETO.pdf: 1770308 bytes, checksum: 4220afcfa71b4f29b7880a79649bc375 (MD5) Previous issue date: 2012-08-29 / Hand hygiene is an important procedure in preventing peritoneal dialysis-related infections. OBJECTIVE: To compare the effectiveness of two distinct techniques for hand hygiene in reducing the number of colony-forming units in patients on peritoneal dialysis. PATIENTS AND METHOD: Observational study. Twenty-two patients underwent two collections of microbiological flora from the hands in two different instances: after hand washing with non-antimicrobial soap and water followed by rubbing with 70% ethyl alcohol, gel presentation, after application of 70% ethyl alcohol, presentation gel. Cultures were obtained by applying the fingers surface directly on agar-blood plates. RESULTS: The comparison between groups showed a significant difference (p <0.01) in colony-forming units in the right hands and left hands, mean 59.6 ? 43.1 in the group not antimicrobial soap and water, proved higher than in group 70% ethyl alcohol, presentation gel (31.8 ? 39.9). This difference is characterized by the presence of colonies of Staphylococcus coagulase-negative, and this was predominant in the seed crops. CONCLUSION: Hand rubbing with gel-alcohol was more effective in reducing the number of colonies recovered than the other methods. / INTRODU??O: A higieniza??o das m?os ? um importante procedimento para a preven??o de infec??es relacionadas a di?lise peritoneal. OBJETIVO: comparar a efic?cia de duas t?cnicas de higieniza??o das m?os, na redu??o do n?mero de unidades formadoras de col?nia em pacientes em programa de di?lise peritoneal. MATERIAIS E M?TODO: Estudo observacional, transversal. Vinte e dois indiv?duos submetidos a duas coletas da flora microbiol?gica das m?os, em dois momentos distintos: ap?s higieniza??o das m?os com ?gua e sab?o n?o antimicrobiano seguida de fric??o com ?lcool et?lico 70%, apresenta??o gel; ap?s aplica??o de ?lcool et?lico 70%, apresenta??o gel. Culturas obtidas da superf?cie dos dedos das m?os, diretamente em placas de Agar Sangue de Carneiro. RESULTADOS: A compara??o entre grupos mostrou uma diferen?a significativa (p<0,01), nas unidades formadoras de col?nia nas m?os direitas e m?os esquerdas, a m?dia 59,6?43,1 do grupo ?gua e sab?o n?o antimicrobiano; mostrou-se mais elevada que no grupo ?lcool et?lico 70%, apresenta??o gel (31,8?39,9). Esta diferen?a ? caracterizada pela presen?a de col?nias de Staphyloccocus coagulasenegativa, sendo que este foi o germe prevalente nas culturas. CONCLUS?O: A higieniza??o com ?lcool et?lico 70%, apresenta??o gel produziu maior redu??o no n?mero de unidades formadoras de col?nia.

Submitted by PPG Gerontologia Biom?dica (geronbio@pucrs.br) on 2017-07-19T13:29:23Z No. of bitstreams: 1 SILVA_PATRICIA_ZAMBONE_DA_TESE.pdf: 2537968 bytes, checksum: 818511856a7e650015c59ec1bcccaedc (MD5) / Rejected by Caroline Xavier (caroline.xavier@pucrs.br), reason: Devolvido devido a falta de capa institucional. on 2017-07-28T20:35:05Z (GMT) / Submitted by PPG Gerontologia Biom?dica (geronbio@pucrs.br) on 2017-07-31T13:19:01Z No. of bitstreams: 1 SILVA_PATRICIA_ZAMBONE_DA_TESE.pdf: 2589449 bytes, checksum: 9286601e1e2732bceedf78741bb0d87a (MD5) / Approved for entry into archive by Caroline Xavier (caroline.xavier@pucrs.br) on 2017-08-03T17:49:44Z (GMT) No. of bitstreams: 1 SILVA_PATRICIA_ZAMBONE_DA_TESE.pdf: 2589449 bytes, checksum: 9286601e1e2732bceedf78741bb0d87a (MD5) / Made available in DSpace on 2017-08-03T18:05:42Z (GMT). No. of bitstreams: 1 SILVA_PATRICIA_ZAMBONE_DA_TESE.pdf: 2589449 bytes, checksum: 9286601e1e2732bceedf78741bb0d87a (MD5) Previous issue date: 2017-04-27 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior - CAPES / Organic changes caused by aging cause clinical manifestations in several situations common to elderly patients. Among them, the aging process is associated with a decline in muscle mass and strength. Several factors are involved in this mechanism, among them low D vitamin. OBJECTIVES: verify the effect of D vitamin supplementation on handgrip strength and body composition in elderly women. METHODS: A longitudinal, interventional, uncontrolled study with 54 elderly women at community who do not have severe disabling diseases and do not take D vitamin supplementation. Serum (25 (OH) D) below 30 ng / mL were inclusion criteria in the study. The elderly women performed handgrip strength test (FM), body composition examination by DXA and laboratory tests (parathyroid hormone (PTH), urea (Ur), creatinine (Cr), serum calcium (Ca++) and interleukin-6)). Participants with serum vitamin D levels between 20-29.9 ng/mL were supplemented with 2000 IU per day of cholecalciferol for twelve weeks and those with levels below 20 ng/mL received 10000 IU per day of cholecalciferol for the same period. All had concomitant taking of calcium carbonate 1 g per day. At the end, handgrip strength test, biochemical evaluation and body composition were repeated. For the description of the sample, mean, standard deviation and percentage were used. For data correlation with normal distribution were used Pearson correlation test, and for comparison, Student's T test and for data with non-normal distribution, median, Spearman, Mann-Whitney U and Wilcoxon correlation test. RESULTS: Of the 54 elderly women included in the study, 52 concluded. The mean age was 72 ? 9 years. The mean value before and after supplementation were 25 (OH) D 18.9 ? 6.65 and 38.15 (24.4 ? 126.2) (p= 0,000), PTH 87.15 ? 40.08 and 67.55 ? 30.04 (p = 0,000), IL-6 3.6 (1.5 ? 15.8) and 2.25 (1.5 ? 45.9) (p = 0.04), FM 42.17 ? 14.12 and 42.55 ? 12.78 (p = 0,733), MM 38663 ? 5546 and 38159 ? 6186 (p = 0,132), Ca++ 9,56 ? 0,4 and 9,4 ? 0,35 (p = 0,004). The correlation analysis between variables after the intervention showed an inverse correlation between 25 (OH) D and PTH, FM and IL-6 and between Ca++ and IL-6. Direct correlations occurred between FM and MM and between FM and Ca++. CONCLUSION: Vitamin D supplementation increased serum levels of 25 (OH) D significantly, as well as reduced serum PTH and IL-6 levels, without changes in handgrip strength and total body lean mass. / Mudan?as org?nicas provocadas pelo envelhecimento originam manifesta??es cl?nicas em v?rias situa??es habituais aos pacientes idosos. Dentre elas, o processo de envelhecimento est? associado a um decl?nio na massa e for?a muscular. V?rios fatores est?o envolvidos nesse mecanismo, dentre eles, destaca-se a defici?ncia da vitamina D. OBJETIVO: verificar o efeito da suplementa??o de vitamina D na for?a de preens?o palmar e composi??o corporal em idosas. M?TODOS: Estudo longitudinal, intervencionista, n?o controlado com 54 idosas da comunidade que n?o possuam doen?as incapacitantes graves e que n?o utilizem reposi??o de vitamina D. N?veis s?ricos de vitamina D (25(OH)D) inferiores a 30 ng/mL foram crit?rios de inclus?o no estudo. As idosas realizaram teste de for?a de preens?o manual (FM), exame de composi??o corporal por DXA e exames laboratoriais (paratorm?nio (PTH), ureia (Ur), creatinina (Cr), c?lcio s?rico (Ca++) e interleucina-6 (IL-6)). As participantes com n?veis s?ricos de vitamina D entre 20 ? 29,9 ng/mL foram suplementadas com 2000 UI ao dia de colecalciferol durante dozes semanas e as com n?veis inferiores a 20 ng/mL receberam 10000 UI ao dia de colecalciferol pelo mesmo per?odo. Todas fizeram uso concomitante de carbonato de c?lcio 1 g ao dia. Ao final do per?odo de reposi??o, foram repetidos os testes de for?a manual, avalia??o bioqu?mica e composi??o corporal. Para a descri??o da amostra, foram utilizados m?dia, desvio-padr?o e percentual. Para a correla??o dos dados com distribui??o normal foi utilizado o teste de correla??o de Pearson, e para compara??o, teste T de Student e para os dados com distribui??o n?o-normal, utilizou-se o teste de correla??o de Spearman, Mann-Whitney U e Wilcoxon. RESULTADOS: Das 54 participantes, 52 idosas aderiram ao estudo, com idade m?dia de 72 ? 9 anos. Os valores m?dios antes e depois da interven??o foram 25(OH)D 18,9 ? 6,65 e 38,15 (24,4 ? 126,2) (p= 0,000), PTH 87,15 ? 40,08 e 67,55 ? 30,04 (p = 0,000), IL-6 3,6 (1,5 ? 15,8) e 2,25 (1,5 ? 45,9) (p = 0,04), FM 42,17 ? 14,12 e 42,55 ? 12,78 (p = 0,733) , Massa Magra (MM) 38663 ? 5546 e 38159 ? 6186 (p = 0,132), Ca++ 9,56 ? 0,4 e 9,4 ? 0,35 (p = 0,004). A an?lise de correla??o entre as vari?veis ap?s a interven??o demonstrou rela??o inversa entre 25(OH)D e PTH, FM e IL -6 e entre Ca++ e IL-6. Correla??es diretas ocorreram entre FM e MM e entre FM e Ca++ CONCLUS?O: A suplementa??o de vitamina D aumentou os n?veis s?ricos de 25(OH)D, bem como reduziu os valores de PTH e IL-6, n?o havendo modifica??es na for?a de preens?o palmar e massa magra corporal total.

Submitted by PPG Gerontologia Biom?dica (geronbio@pucrs.br) on 2017-07-14T16:53:09Z No. of bitstreams: 1 NEUSA_MARIA_DE_OLIVIERA_CHARDOSIM_DIS.pdf: 1271158 bytes, checksum: 623f6cdc94a2edddc2c1886237153887 (MD5) / Rejected by Caroline Xavier (caroline.xavier@pucrs.br), reason: Devolvido devido a falta da capa institucional. on 2017-07-28T18:37:05Z (GMT) / Submitted by PPG Gerontologia Biom?dica (geronbio@pucrs.br) on 2017-07-31T16:40:16Z No. of bitstreams: 1 NEUSA_MARIA_DE_OLIVIERA_CHARDOSIM_DIS.pdf: 1323468 bytes, checksum: a556822f2b56df09e333d35a781b8af4 (MD5) / Approved for entry into archive by Caroline Xavier (caroline.xavier@pucrs.br) on 2017-08-03T18:58:25Z (GMT) No. of bitstreams: 1 NEUSA_MARIA_DE_OLIVIERA_CHARDOSIM_DIS.pdf: 1323468 bytes, checksum: a556822f2b56df09e333d35a781b8af4 (MD5) / Made available in DSpace on 2017-08-03T19:06:03Z (GMT). No. of bitstreams: 1 NEUSA_MARIA_DE_OLIVIERA_CHARDOSIM_DIS.pdf: 1323468 bytes, checksum: a556822f2b56df09e333d35a781b8af4 (MD5) Previous issue date: 2017-03-28 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior - CAPES / Parkinson's disease (PD) is a degenerative and progressive disease of the central nervous system, which is characterized by neuronal death in the substantia nigra, with consequent decrease of dopamine, leading to typical motor alterations. In addition to the motor symptoms, cognitive and behavioral changes occur, which have been shown to be a preponderant factor for the worsening of the patients' disease. It is a disease whose prevalence increases with age, reaching 1% in individuals over 60 years. With the increase in life expectancy, it is estimated that millions of people in the world will be carriers of PD. Thus, the main objective of this study was to investigate the relationship between personality factors, cognitive functioning and depressive and anxiety symptoms in the elderly with PD. In addition, it aimed to: a) characterize the cognitive functioning, personality factors and prevalence of depressive and anxiety symptoms in elderly with PD; B) to verify relationships among the factors of personality, age, schooling, depressive symptoms and of anxiety and cognitive performance; C) analyze whether personality factors are predictors of the cognitive functioning of elderly with PD. This study had a cross-sectional, correlational and exploratory design. The sample was recruited for convenience, consisting of 30 elderly people with PD, aged 60-86 years (M = 68.97; SD = 6.35). Participants responded to a Sociodemographic Data Sheet, the NEO-FFI-R, the Montreal Cognitive Assessment (MoCA), the Beta-III (matrix reasoning), the verbal phonemic fluency test (FAS) and semantics (Animals), the subtests digits span of the Wechsler Adult Intelligence Scale (WAIS-III) and the Boston Naming Test and the word list of the CERAD battery, the Geriatric Depression Scale (GDS-15) and the Anxiety Inventory of Beck (BAI). The elderly with PD presented impairments in the functions of verbal episodic memory (immediate recall, late recall and recognition) and executive functions (abstract reasoning and problem solving). Among the elderly evaluated, 43% had depressive symptoms and 27% had anxiety symptoms. Participants demonstrated low levels of neuroticism, extroversion and openness to experience, and high levels ofagreeableness and conscientiousness. The extroversion factor was positively correlated with executive functions (verbal fluency) and the openness to experience factor was positively correlated with verbal episodic memory (late recall). Together, extroversion and aperture factors have been shown to be the strongest predictors of the performance of elderly with PD in verbal episodic memory tasks (late recall). The extroversion factor only contributes to the performance of the elderly with PD in memory tasks (immediate recall and recognition) and executive functions (verbal phonemic and semantic fluency). It is concluded that the elderly with DP present memory impairment and executive functions. The extroversion factor is the factor that contributes most to the performance of the elderly with PD in memory tasks and executive functions. / A Doen?a de Parkinson (DP) ? uma doen?a degenerativa e progressiva do sistema nervoso central, que se caracteriza por morte neuronal na subst?ncia negra, com consequente diminui??o de dopamina, levando a altera??es motoras t?picas. Al?m dos sintomas motores, ocorrem altera??es cognitivas e comportamentais, que t?m se mostrado como um fator preponderante para o agravamento da doen?a dos pacientes. ? uma doen?a cuja preval?ncia aumenta com a idade, chegando a 1% em indiv?duos acima de 60 anos. Com o aumento da expectativa de vida, estima-se que milh?es de pessoas no mundo ser?o portadoras da DP. Assim, o presente estudo teve como principal objetivo investigar a rela??o entre fatores de personalidade, funcionamento cognitivo e sintomas depressivos e de ansiedade em idosos com a DP. Al?m disso, buscou: a) caracterizar o funcionamento cognitivo, os fatores de personalidade e a preval?ncia de sintomas depressivos e de ansiedade em idosos com DP; b) verificar rela??es entre os fatores de personalidade, idade, escolaridade, sintomatologia depressiva e de ansiedade e desempenho cognitivo; c) analisar se os fatores de personalidade s?o preditores do funcionamento cognitivo de idosos com DP. Este estudo teve um delineamento transversal, correlacional e explorat?rio. A amostra foi recrutada por conveni?ncia, sendo composta por 30 idosos com DP,com idades entre 60 a 86 anos (M=68,97; DP=6,35). Os participantes responderam a uma Ficha de dados sociodemogr?ficos,o NEO-FFI-R, o Montreal Cognitive Assessment (MoCA), o subteste racioc?nio matricial do Teste de Intelig?ncia n?o verbal (Beta-III), o Teste de Flu?ncia Verbal Fon?mica (FAS) e Sem?ntica (Animais), o subteste d?gitos da Escala de Intelig?ncia Wechsler para adultos (WAIS-III) e os subtestes lista de palavras e Teste de nomea??o de Boston da bateria CERAD, a Escala de Depress?o Geri?trica (GDS-15) e o Invent?rio de Ansiedade de Beck (BAI). Os idosos com DP apresentaram preju?zos nas fun??es de mem?ria epis?dica verbal (evoca??o imediata, tardia e reconhecimento) e fun??es executivas (racioc?nio abstrato e resolu??o de problemas). Dentre os idosos avaliados, 43% apresentaram sintomas depressivos e 27% sintomas de ansiedade. Os participantes demonstraram baixos n?veis de neuroticismo, de extrovers?o e abertura ? experi?ncia e altos n?veis de amabilidade e conscienciosidade. O fator extrovers?o correlacionou-se de maneira positiva com fun??es executivas (flu?ncia verbal) e o fator abertura a experi?ncia correlacionou-se positivamente com mem?ria epis?dica verbal (evoca??o tardia). Conjuntamente, os fatores extrovers?o e abertura demonstraram-se como os preditores mais fortes do desempenho de idosos com DP em tarefas de mem?ria epis?dica verbal (evoca??o tardia). O fator extrovers?o, unicamente, contribui para o desempenho de idosos com DP em tarefas de mem?ria (evoca??o imediata e reconhecimento) e em fun??es executivas (flu?ncia verbal fon?mica e sem?ntica). Conclui-se que idosos com DP apresentam preju?zos na mem?ria e fun??es executivas. O fator extrovers?o ? o fator que mais contribuiu para o desempenho de idosos com DP em tarefas de mem?ria e em fun??es executivas.