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71	”Vill du ha plusmeny till det samhällsansvaret?” : - En språkvetenskaplig och filmanalytisk studie om effekten av Covid-19 på svenska hamburgerkedjors marknadsföring / “Would you like to supersize that social responsibility?” : – A linguistic and film analytic study about the effects of Covid-19 on the marketing of Swedish hamburger restaurants Lindqvist, Wilhelm January 2020 (has links) Denna studie syftar till att undersöka hur Sveriges tre största hamburgerkedjor tagit sig an Covid-19- krisens utmaningar i sina reklamfilmer. Förhoppningen är att resultatet ska kunna bidra med kunskap om hur kriser av det här slaget kan hanteras när det handlar om marknadsföring samt hur marknadsföringen i sig kan uppfattas, både av mottagare och av de som står bakom den. Studien har analyserat åtta reklamfilmer, hälften från 2019 och hälften från 2020 för att kartlägga dels vad som kännetecknar de olika hamburgerkedjornas reklam under dessa år men också hur kedjorna vill framställa sig i sina mottagares ögon och om det har förändrats i och med Covid-19. Detta har gjorts med filmanalyser för de visuella och semiotiska resurserna i reklamfilmerna men också textanalyser med hjälp av den systemisk-funktionella lingvistikens metafunktioner för en bredare förståelse av de övergripande budskapen. Resultaten visar på likheter i kedjornas sätt att bygga upp sina reklamfilmer 2020 runt det övergripande budskapet att man tar Covid-19-viruset på allvar och prioriterar kundsäkerhet och samhällsansvar. Alla tre verksamheter är också noga med att framstå som givande och inte krävande. Det finns dock också skillnader i hur man förmedlar detta, exempelvis när det gäller distans till mottagaren, kampanjer och rollen som respektive kedja ämnar ta på sig i relation till mottagaren. Vidare går det även att identifiera återkommande mönster i resultaten från både tidigare forskning och reklamfilmerna från 2019 i alla tre kedjors Covid-19-anpassning där framförallt lättsamhet kontra allvar är tydligt. Commercial hamburger restaurants fast food marketing film clip analysis sociosemiotics systemic functional linguistics covid-19 Reklamfilm hamburgerrestauranger snabbmat marknadsföring filmanalys sociosemiotik systemisk funktionell lingvistik covid-19 General Language Studies and Linguistics
72	Optimalizace indikací chirurgického a endovaskulárního ošetření intrakraniálních aneurysmat. / Optimalised indications for microsurgical and endovascular treatment of intracranial aneurysms. Štekláčová, Anna January 2018 (has links) Univerzita Karlova v Praze 1. lékařská fakulta Autoreferát disertační práce Optimalizace indikací chirurgického a endovaskulárního ošetření intrakraniálních aneurysmat Anna Štekláčová 2018 2 Doktorské studijní programy v biomedicíně Univerzita Karlova v Praze a Akademie věd České republiky Obor: Neurovědy Předseda oborové rady: Prof. MUDr. Karel Šonka, DrSc. Školicí pracoviště: Neurochirurgická a neuroonkologická klinika 1. LF UK a ÚVN, Praha Školitel: Prof. MUDr. Vladimír Beneš, DrSc. Disertační práce bude nejméně pět pracovních dnů před konáním obhajoby zveřejněna k nahlížení veřejnosti v tištěné podobě na Oddělení pro vědeckou činnost a zahraniční styky Děkanátu 1. lékařské fakulty. 3 Obsah Abstrakt - Česky ..................................................................................... 4 Abstract - English ................................................................................... 5 Úvod........................................................................................................ 6 Hypotézy a cíle studie............................................................................. 6 Materiál a metody ................................................................................... 7 Výsledky...
73	STUDIES ON THE SIZE AND NON-PLANARITY OF AROMATIC STACKING MOIETY ON CONFORMATION SELECTIVITY AND THERMAL STABILIZATION OF G-QUADRUPLEXES Singh, Mandeep 01 January 2020 (has links) (PDF) Targeting DNA has the advantage over proteins for cancer remediation because of the fewer copies of the ligands required for the desired therapeutic effect. Traditionally, covalent DNA binders like alkylating agents have been used to induce genetic instability through the formation of DNA lesions and strand breaks, leading to cellular apoptosis. The primary drawback of this treatment is the non-specific binding that affects both cancerous and non-cancerous cells. G-quadruplexes are the DNA secondary structures that are present in abundance near the promoter regions of the oncogenes and are involved in the regulation of their activities. A ligand-mediated stabilization of G-quadruplexes in the promoter regions and down-regulation of the associated oncogenes have been validated. In contrast to alkylating agents, G-quadruplex ligands induce genetic stabilization through non-covalent interactions. They can be designed to interact specifically with G-quadruplex DNA over duplex DNA, which reduce side effects arising from the off-targeting. G-quadruplex ligands invariably have the large planar aromatic moiety to interact with G-quadruplexes through π- π stacking interactions. For determining the size effect of the aromatic moiety on stabilization of G-quadruplexes, a series of ligands were synthesized by conjugating nucleobases or 1,10-phenanthroline with an aminoglycoside, neomycin. The resulting conjugates increased the binding affinity synergistically and enabled us to study the effect of the stacking moiety required for G-quadruplex stabilization. Nucleobase-neomycin conjugates did not show stabilization stabilize of human telomeric G-quadruplex. 1,10-Phenanthroline-neomycin conjugate (7b) on the other hand binds to human telomeric G-quadruplex with a Ka of (8.92.4)×108 M-1 and inhibits telomerase activity at 1.56 µM probably through G-quadruplex stabilization. Moving forward, we further enlarged the aromatic moiety by tethering two 1,10-phenantholine molecules together through a five-atom linker. The resulting molecule (2-Clip-phen) was conjugated with various amino-containing side chains. 2-Clip-phen derivatives showed at least 30 times weaker binding to duplex DNA over G-quadruplex DNA. In addition, compounds showed a preference for the antiparallel G-quadruplex conformation over parallel and hybrid G-quadruplex conformations, as shown in the CD spectroscopy studies. Ligands 11 and 13 induced the formation of an antiparallel G-quadruplex from random coils and stabilize it to 60 oC (Tm) in a salt-free condition. Mass spectrometry study showed the formation of a two-tetrad G-quadruplex with the 2-Clip-phen ligand. Docking study showed that the ligand interacts most favorably with antiparallel G-quadruplex conformation, which is supported further by the larger thermal stabilization effect on antiparallel G-quadruplex compared with other G-quadruplex conformations. Our study suggests that 2-Clip-phen can be used as a scaffold for designing G-quadruplex binding ligands that preferentially bind to antiparallel G-quadruplexes, which has never been reported before. 2-CP = 2-Clip-phen CD = Circular dichroism G4 = G-quadruplex ITC = Isothermal titration calorimetry Organic chemistry Pharmaceutical sciences Chemistry Medicinal and Pharmaceutical Chemistry Medicinal-Pharmaceutical Chemistry Medicine and Health Sciences Organic Chemistry Pharmacy and Pharmaceutical Sciences Physical Sciences and Mathematics
74	Exploring Determinants of Self-Regulatory Behavior and Schedules of Extended Care Contact for Weight Loss Maintenance: Results of the Randomized Controlled Collaborative Lifestyle Intervention Program in Knee Osteoarthritis Expansion Pilot Trial Chaplow, Zachary L. 11 August 2022 (has links) No description available. Kinesiology Social Psychology Health Sciences Experiments Cognitive Psychology Behavioral Sciences Aging CLIP-OA overweight obesity weight loss weight loss maintenance osteoarthritis older adult lifestyle exercise diet intervention behavioral weight management social cognitive theory health action process approach HAPA group mediated cognitive behavioral GMCB counseling extended care mobility disability videoconferencing Zoom
75	Mecanismes de regulació en l'activitat biològica del factor de transcripció Snail Domínguez Solà, David 03 April 2003 (has links) Els factors de transcripció de la família Snail són fonamentals en la "transició epiteli-mesènquima", procés morfogènic essencial en el desenvolupament embrionari i en els fenòmens metastàsics tumorals.En els mamífers l'activitat d'Snail és modulada per dos mecanismes. (i) En el promotor humà es troben regions definides de resposta a factors repressors, predominants en les cèl·lules epitelials, i elements diferenciats de resposta a inductors de la "transició epiteli-mesènquima". (ii) L'activitat d'Snail és condicionada també per la seva localització subcel·lular, modulada per mecanismes no transcripcionals: la fosforilació d'Snail determina si és o no exclós del nucli. Al citosol no pot actuar com a repressor transcripcional però pot interaccionar amb la xarxa microtubular, que estabilitza i en condiciona el dinamisme. Això coincideix amb l'activació de la GTPasa RhoA i la reorientació dels filaments de vimentina, fets associats a l'adquisició de capacitat migratòria. L'efecte com a repressor transcripcional i la modulació del dinamisme microtubular són possiblement esdeveniments coordinats necessaris per al rol biològic d'Snail en mamífers. / Snail family of transcription factors is fundamental to the "epithelial-mesenchymal transition", morphogenic process essential to embryonic development and metastatic phenomena in tumors.Snail's activity is modulated in two ways in mammals. (i) The human promoter harbors definite regions that respond to repressor factors, which prevail in epithelial cells; and differentiated elements that respond to known inducers of the "epithelial-mesenchymal transition". (ii) Snail's activity is also conditioned by its subcellular localization, mechanism not dependent on its transcriptional control: Snail phosphorylation determines whether Snail is excluded or not from the nucleus. When in the cytosol, Snail is unable to act as a transcriptional repressor, but however binds to the microtubular meshwork, which becomes stabilized and whose dynamism is conditioned as a result. This fact coincides with the activation of the RhoA GTPase and reorientation of vimentin filaments, both phenomena being related to the acquisition of cell motility. The transcriptional repressor and the microtubule dynamics effects are probably two coordinated events necessary to Snail's biological role in mammals. Polimerització in vitro PKCzeta PKC atípica (Protein Kinase C) P65 Promotor Nocodazol NF-kB/Dorsal (Nuclear Factor Kappa-B) NES (seqüència d'export nuclear) Microtúbuls detirosinats Microtúbuls Metàstasi Invasió Adenocarcinoma ARNm Beta-catenina Centrosoma CLIP-170 Cancer Cresta neural CRM1 (Chromosome Region Maintenance 1) Despolimerització microtúbuls Dit de Zenc atípic Dit de Zenc Domini ric en Serines Ebox E-cadherina Espais intercromatínics Estabilització microtúbuls Export nuclear Filaments intermediaris Fosforilació Gastrulació GFP (Green Fluorescent Protein) Heterocarions ILK (Integrin Linked Kinase) Promotor Reconstrucció fronts invasius Regulació Retrogen RhoA GTPasa SC35 Slug SNAG (domini) SNAI1L Snail Speckles nuclears Time-lapse Èster de forbol Transició Epiteli-Mesènquima Transcripció / Transcripcional U2AF65 Vimentina 57

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