När förlossningsprogressen går långsamt fram eller stannar av helt kan barnmorskan använda sig av läkemedlet Oxytocin® för att framkalla tätare och mer intensiva värkar och på så sätt uppnå progress i förlossning. Oxytocin® är ett potent läkemedel som när det används felaktigt kan ge allvarliga komplikationer för mor och barn. I Sverige togs nationella riktlinjer för oxytocinbehandling vid värksvaghet fram år 2011. Barnmorskan har även lokala riktlinjer att förhålla sig till i sitt dagliga arbete. Studier har visat att oxytocinbehandling sker på ett ostrukturerat sätt i Sverige. Syftet med studien var att undersöka Sveriges förlossningsklinikers PM följsamhet till de nationella riktlinjerna framtagna år 2011 gällande oxytocinbehandling vid värksvaghet. Studien utgjordes av en kvantitativ, komparativ metod med en deskriptiv ansats, där urvalet resulterade i insamlade data från 43 av landets 44 förlossningskliniker. Ett instrument för dataanalys framtogs där samtliga PM jämfördes mot den text som var formulerad i de nationella riktlinjernas föreslagna PM och presenterades genom deskriptiv statistik. Resultatet visade på en variation i följsamhet i de lokala PM:en till de nationella riktlinjerna. Fem klinikers PM överensstämde med de nationella riktlinjernas PM på samtliga punkter. Ytterligare fyra klinikers PM överensstämde på alla punkter förutom gällande riktlinjer kring dokumentation. Knappt två tredjedelar av klinikerna överensstämde till 75 procent eller mer av de punkter som jämfördes i instrument för dataanalys. Ett fåtal klinikers följsamhet var 25 procent eller lägre. Vidare ansågs varken de nationella eller lokala riktlinjerna vara reviderade utifrån den senaste forskningen och evidensen. Studiens slutsats var att kliniker bör se över sina riktlinjer gällande oxytocinbehandling vid värksvaghet för att kunna erbjuda födande kvinnor i Sverige en jämlik och patientsäker vård.

Les objectifs de la thèse sont l'a nalyse approfondie d'un système de supervision automatique de la ventilation artificielle des patients hospitalisés en soins intensifs et l'élaboration de solutions pour améliorer et étendre son fonctionnement. Ce système adapte l'assistance en pression de la ventilation spontanée avec aide inspiratoire (AI) par un rétrocontrôle basé sur la fréquence respiratoire du patient et, comme variables de "sécurité", le volume courant et le CO2 de fin d'expiration (etCO2). Il établit ainsi une classification ventilatoire et règle un niveau de pression d'AI.Sur la base d'études publiées rapportant des limitations, d'analyses d'une base de données rétrospectives acquises sur patient, d'études sur banc-test et d'études observationnelles prospectives réalisées chez les patients, nous avons étudié précisément le fonctionnement du système. Pour la plupart des limitations, une solution a été proposée et évaluée sur banc. A partir d'une étude clinique, nous avons proposé une amélioration de la procédure de traitement du signal etCO2 par le système. En nous basant sur les observations de la base de données, nous avons décrit une procédure automatisée de sevrage de la PEP dont un niveau supérieur à 5 mbar entrave le sevrage par le système. Sur le même principe, nous avons souhaité, en amont de l'AI, tenter d'automatiser un changement de mode depuis la ventilation assistée contrôlée. Au travers d'une étude clinique, nous avons déterminé des critères ventilatoires qui pourraient permettre d'automatiser cette procédure. L'ensemble a permis la définition d'une méthodologie d'évaluation et d'amélioration d'un système automatisé de ventilation artificielle / The objectives of the thesis are the detailed analysis of an automated system of management of artificial ventilation for patients in intensive care unit and the elaboration of solutions to improve and upgrade its functioning. This system automatically adapts the level of pressure support ventilation (PSV) through a feedback based on the respiratory rate of the patient and, as “safety” variables, the tidal volume and the end tidal of expired CO2 (etCO2). The system, called “SmartCare”, establishes a ventilatory classification and sets a level of inspiratory pressure.We precisely studied the system functioning on the basis of published studies reporting limitations, on a database analysis compound with retrospective data acquired on patients, of bench-test studies and observational prospective studies performed in patients. For most of the limitations, a solution was proposed and evaluated on bench. Using the results of a clinical study, we proposed an improvement of etCO2 signal processing. From observations of the database, we described a procedure of automated weaning of positive end expiratory pressure level which hinders pressure support weaning if above 5 mbar. On the same principle, upstream to PSV, we wished to automate a change of ventilation mode from assist control ventilation. Through a clinical study, we determined ventilatory criteria which could allow automation of this procedure. The whole project allowed to define a methodology of evaluation and improvement of an automated mechanical ventilation system

Sammanfattning Bakgrund:Preoperativ helkroppstvätt syftar till att förhindra postoperativa infektioner.Forskningen kan idag inte uttala sig om att klorhexidintvål är ett bättre alternativ än vanlig tvål att använda vid den preoperativa helkroppstvätten för att förhindra uppkomsten av postoperativa infektioner. Det ställs krav på att vården ska bedrivas evidensbaserat för att kunna ge en säker vård till patienterna. För att den evidensbaserade vården ska kunna implementeras kliniskt krävs väl utformade riktlinjer. Riktlinjerna kan ge stöd och klara direktiv för vårdandet av patienten. Syfte:Att systematiskt bedöma och jämföra kvaliteten i kliniska riktlinjer som innefattar preoperativ helkroppstvätt utifrån AGREE II.  Metod:En empirisk studie med kvantitativ forskningsansats av icke-experimentell design. Urvalet utgjordes av en region i Mellansverige där 46 riktlinjer inkluderades som beskrev den preoperativa helkroppstvätten. Bedömningen av kvaliteteten i riktlinjerna genomfördes med hjälp av AGREE II och en jämförelse mellan de fyra olika verksamhetsområdena utfördes med analytisk statistik i form av Kruskal-Wallis test.  Resultat: Huvudfynden i studien visar på att det inte fanns någon tydlig information och syfte i riktlinjerna om preoperativ helkroppstvätt samt att det varierade avseende vilket medel som används till duschen. Det fanns en tydlig brist i vad informationen i riktlinjerna baserades på.  Slutsats: Det påvisas tydligt att det som stod i riktlinjerna inte var grundade i evidens. Sverige bör på nationell nivå ta ställning till hur den preoperativa helkroppstvätten ska utföras. Vidare bör forskning bedrivas om preoperativ helkroppstvätt är en del av det preventiva arbetet mot postoperativa infektioner. / Abstract Background: Preoperative bodywash aims to prevent surgical site infections. However, there is no evidence supporting that chlorhexidine soap is a better alternative for preoperative bodywash than plain soap in the prevention of surgical site infections. The requirement is that the care must be conducted evidence-based in order to provide a safe patient care. Well-designed guidelines are required so that the evidence-based care can be implemented clinically.  Aim:To systematically evaluate and compare the quality of clinical guidelines for preoperative bodywash using the AGREE II instrument. Method: A quantitative empirical study with non-experimental design. The sample was made of a province in Central Sweden. 46 guidelines describing the preoperative bodywash were included. Using the AGREE II instrument the assessment of the guidelines where obtained and presented with descriptive statistics. The comparison between the sections within the province was carried out by using the Kruskal-Wallis test.  Results: The main finding in the study shows that there was no clear scope and purpose in the guidelines on preoperative bodywash and it varied in terms of which agent was used for the shower. The development of the guidelines where inadequate in its rigour for development. Conclusion:The gap between what research concludes and what is performed still exists in the guidelines. A national board should take action to developing nationwide guidelines regarding preoperative bodywash. Further research should be conducted if preoperative bodywash is part of the prevention against surgical site infections.

In medicine, data are produced from different sources and continuously stored in data depositories. Examples of these growing databases are quality registries. In Sweden, there are many cancer registries where data on cancer patients are gathered and recorded and are used mainly for reporting survival analyses to high level health authorities. In this thesis, a breast cancer quality registry operating in South-East of Sweden is used as the data source for newer analytical techniques, i.e. data mining as a part of knowledge discovery in databases (KDD) methodology. Analyses are done to sift through these data in order to find interesting information and hidden knowledge. KDD consists of multiple steps, starting with gathering data from different sources and preparing them in data pre-processing stages prior to data mining. Data were cleaned from outliers and noise and missing values were handled. Then a proper subset of the data was chosen by canonical correlation analysis (CCA) in a dimensionality reduction step. This technique was chosen because there were multiple outcomes, and variables had complex relationship to one another. After data were prepared, they were analyzed with a data mining method. Decision tree induction as a simple and efficient method was used to mine the data. To show the benefits of proper data pre-processing, results from data mining with pre-processing of the data were compared with results from data mining without data pre-processing. The comparison showed that data pre-processing results in a more compact model with a better performance in predicting the recurrence of cancer. An important part of knowledge discovery in medicine is to increase the involvement of medical experts in the process. This starts with enquiry about current problems in their field, which leads to finding areas where computer support can be helpful. The experts can suggest potentially important variables and should then approve and validate new patterns or knowledge as predictive or descriptive models. If it can be shown that the performance of a model is comparable to domain experts, it is more probable that the model will be used to support physicians in their daily decision-making. In this thesis, we validated the model by comparing predictions done by data mining and those made by domain experts without finding any significant difference between them. Breast cancer patients who are treated with mastectomy are recommended to receive radiotherapy. This treatment is called postmastectomy radiotherapy (PMRT) and there is a guideline for prescribing it. A history of this treatment is stored in breast cancer registries. We analyzed these datasets using rules from a clinical guideline and identified cases that had not been treated according to the PMRT guideline. Data mining revealed some patterns of non-compliance with the PMRT guideline. Further analysis with data mining revealed some reasons for guideline non-compliance. These patterns were then compared with reasons acquired from manual inspection of patient records. The comparisons showed that patterns resulting from data mining were limited to the stored variables in the registry. A prerequisite for better results is availability of comprehensive datasets. Medicine can take advantage of KDD methodology in different ways. The main advantage is being able to reuse information and explore hidden knowledge that can be obtained using advanced analysis techniques. The results depend on good collaboration between medical informaticians and domain experts and the availability of high quality data.

This research study explored and described a partogram as a clinical practice guideline for monitoring and managing women during labour at Vhembe District of Limpopo province. A qualitative, explorative, descriptive and contextual design was used in order to achieve the study objectives. Purposive sampling was carried out to select three hospitals in order to obtain comprehensive data from the district. The research study was conducted in three phases. Face-to-face semi-structured interviews were conducted with 17 midwives who were selected conveniently from the three hospitals. Document study was also conducted on 24 partograms that were conveniently selected from the three hospitals on the days that interviews were conducted, using a self-designed checklist. Tesch’s eight steps of qualitative data analysis were used to analyse the data, and simple, descriptive statistics using frequencies were used to analyse the data obtained from the document study. Four themes that emerged from the data are: benefits of implementing the partogram, challenges experienced, attitudes of staff and evaluation on how the guideline is being implemented in the wards, including giving feedback. These aspects were indicated as pivotal in the implementation of the guideline in monitoring a woman during labour. The findings on document study revealed gaps in recording, mostly on aspects that needed frequent observations and on aspects in which resources that needed to be used in monitoring were lacking. The strategies to improve the implementation of a guideline were developed based on the research findings, sent to one of the hospitals for review and comments were included in the discussions. It is recommended that in-service training on the implementation of the partogram be conducted regularly for midwives. Hospital management and supervisors need to provide support, enough staff and equipment in order to enable midwives to use the partogram / Health Studies / D. Litt. et Phil. (Health Studies)

La prise d’un supplément d’acide folique en période préconceptionnelle réduit le risque d’une anomalie du tube neural (ATN), une malformation du système nerveux. Dans le but d’en réduire la prévalence, la Société des Obstétriciens et Gynécologues du Canada a émis de nouvelles directives cliniques en 2007 qui tenaient compte de différents facteurs de risque pour les ATN et pour qui la dose recommandée variait selon le profil de risque de la femme, allant de 0,4 à 5,0 mg d’acide folique. Jusqu’à présent, peu de données sont disponibles sur les effets de la prise d’une haute dose d’acide folique. Les objectifs de cette étude étaient: 1) d’évaluer la concordance entre la supplémentation en acide folique chez les femmes enceintes et les nouvelles recommandations canadiennes; 2) d’identifier les déterminants d’une utilisation concordante et 3) d’évaluer si la prise de hautes doses d’acide folique en période périconceptionnelle réduisait le risque de malformations congénitales autre que les ATN. Pour répondre à ces objectifs, une étude transversale et une étude écologique ont été effectuées. La première incluait 361 femmes enceintes recrutées aux cliniques d’obstétriques du CHU Sainte-Justine et la deuxième utilisait le Registre Québécois des Grossesses, issu du jumelage de trois banques de données administratives au Québec (RAMQ, Med-Écho et ISQ), où 152 392 couples mère-enfant ont été identifiés. Seul 27% des femmes enceintes ayant participé à l’étude transversale avaient une supplémentation en acide folique, avec ou sans ordonnance, concordante aux lignes directrices canadiennes. La concordance variait selon leur profil de facteurs de risque pour les ATN. Notre étude écologique montre que la prévalence annuelle de l’utilisation de haute dose d’acide folique (avec ordonnance) en période périconceptionnelle a augmenté de 0,17% à 0,80% (p < 0,0001) entre 1998 et 2008 et que la prévalence des malformations congénitales majeures a augmenté de 15% au cours de la même période (3,35% à 3,87%, p<0,0001). Les résultats de nos deux études montrent que l’acide folique n’est pas largement utilisé par les femmes en âge de procréer et ce, peu importe la dose. De nouvelles campagnes de santé publique devront être mises sur pied, afin d’inciter les femmes à consommer de l’acide folique avant et pendant leur grossesse. Également, la prise de haute dose d’acide folique ne semble pas avoir diminué le risque de malformations congénitales, à l’échelle populationnelle. / The use of folic acid during the preconceptionnal period reduces the risk of neural tube defects (NTD), a malformation of the nervous system. In order to reduce it’s prevalence, the Society of Obstetricians and Gynaecologists of Canada proposed new practice clinical guidelines, in 2007, on the use of pre-conceptional vitamin/folic acid supplementation for the prevention of NTDs, with specific recommendations to prevent recurrences and occurrences among women with intermediate to high health risk factors and for whom the dose was different. The objectives of this study were to evaluate the concordance between the new guidelines and folic acid use in real life; 2) to identify predictors associated with a recommended folic acid supplementation, and 3) to evaluate if the use of folic acid could reduce the risk of congenital malformations other than NTDs. A cross-sectional study and an ecological study have been conducted. 361 women were recruited in obstetrics outpatient clinic at the CHU Ste-Justine for the first study and 152,392 pregnancies and babies were identified in the Quebec Pregnancy Registry, which results from the linkage of three administrative health care databases from Quebec (RAMQ, Med-Echo and ISQ) for the second study. Only 27% of the wowen recruited for the first study had periconceptional folic acid supplementation intake that was concordant with guideline. Concordance varied according to their health risk factors profile for NTD. Our ecological study showed that the annual prevalence of periconceptional folic acid use increased from 0.17% to 0.80% (p < 0,0001) from 1998 to 2008 and birth prevalence of major congenital malformations increased by 15% (3.35% to 3.87%, p < 0,0001) during the same period. Our findings highlight the fact that folic acid is not widely used by women of childbearing age, regardless of the dose. There is a need for new public health programs to encourange women to consume folic acid every day before and during pregnancy. Moreover, the use of high dose folic acid does not seem to be correlated with a decline in the prevalence of major congenital malformations, on a populational level.

This research study explored and described a partogram as a clinical practice guideline for monitoring and managing women during labour at Vhembe District of Limpopo province. A qualitative, explorative, descriptive and contextual design was used in order to achieve the study objectives. Purposive sampling was carried out to select three hospitals in order to obtain comprehensive data from the district. The research study was conducted in three phases. Face-to-face semi-structured interviews were conducted with 17 midwives who were selected conveniently from the three hospitals. Document study was also conducted on 24 partograms that were conveniently selected from the three hospitals on the days that interviews were conducted, using a self-designed checklist. Tesch’s eight steps of qualitative data analysis were used to analyse the data, and simple, descriptive statistics using frequencies were used to analyse the data obtained from the document study. Four themes that emerged from the data are: benefits of implementing the partogram, challenges experienced, attitudes of staff and evaluation on how the guideline is being implemented in the wards, including giving feedback. These aspects were indicated as pivotal in the implementation of the guideline in monitoring a woman during labour. The findings on document study revealed gaps in recording, mostly on aspects that needed frequent observations and on aspects in which resources that needed to be used in monitoring were lacking. The strategies to improve the implementation of a guideline were developed based on the research findings, sent to one of the hospitals for review and comments were included in the discussions. It is recommended that in-service training on the implementation of the partogram be conducted regularly for midwives. Hospital management and supervisors need to provide support, enough staff and equipment in order to enable midwives to use the partogram / Health Studies / D. Litt. et Phil. (Health Studies)

La prise d’un supplément d’acide folique en période préconceptionnelle réduit le risque d’une anomalie du tube neural (ATN), une malformation du système nerveux. Dans le but d’en réduire la prévalence, la Société des Obstétriciens et Gynécologues du Canada a émis de nouvelles directives cliniques en 2007 qui tenaient compte de différents facteurs de risque pour les ATN et pour qui la dose recommandée variait selon le profil de risque de la femme, allant de 0,4 à 5,0 mg d’acide folique. Jusqu’à présent, peu de données sont disponibles sur les effets de la prise d’une haute dose d’acide folique. Les objectifs de cette étude étaient: 1) d’évaluer la concordance entre la supplémentation en acide folique chez les femmes enceintes et les nouvelles recommandations canadiennes; 2) d’identifier les déterminants d’une utilisation concordante et 3) d’évaluer si la prise de hautes doses d’acide folique en période périconceptionnelle réduisait le risque de malformations congénitales autre que les ATN. Pour répondre à ces objectifs, une étude transversale et une étude écologique ont été effectuées. La première incluait 361 femmes enceintes recrutées aux cliniques d’obstétriques du CHU Sainte-Justine et la deuxième utilisait le Registre Québécois des Grossesses, issu du jumelage de trois banques de données administratives au Québec (RAMQ, Med-Écho et ISQ), où 152 392 couples mère-enfant ont été identifiés. Seul 27% des femmes enceintes ayant participé à l’étude transversale avaient une supplémentation en acide folique, avec ou sans ordonnance, concordante aux lignes directrices canadiennes. La concordance variait selon leur profil de facteurs de risque pour les ATN. Notre étude écologique montre que la prévalence annuelle de l’utilisation de haute dose d’acide folique (avec ordonnance) en période périconceptionnelle a augmenté de 0,17% à 0,80% (p < 0,0001) entre 1998 et 2008 et que la prévalence des malformations congénitales majeures a augmenté de 15% au cours de la même période (3,35% à 3,87%, p<0,0001). Les résultats de nos deux études montrent que l’acide folique n’est pas largement utilisé par les femmes en âge de procréer et ce, peu importe la dose. De nouvelles campagnes de santé publique devront être mises sur pied, afin d’inciter les femmes à consommer de l’acide folique avant et pendant leur grossesse. Également, la prise de haute dose d’acide folique ne semble pas avoir diminué le risque de malformations congénitales, à l’échelle populationnelle. / The use of folic acid during the preconceptionnal period reduces the risk of neural tube defects (NTD), a malformation of the nervous system. In order to reduce it’s prevalence, the Society of Obstetricians and Gynaecologists of Canada proposed new practice clinical guidelines, in 2007, on the use of pre-conceptional vitamin/folic acid supplementation for the prevention of NTDs, with specific recommendations to prevent recurrences and occurrences among women with intermediate to high health risk factors and for whom the dose was different. The objectives of this study were to evaluate the concordance between the new guidelines and folic acid use in real life; 2) to identify predictors associated with a recommended folic acid supplementation, and 3) to evaluate if the use of folic acid could reduce the risk of congenital malformations other than NTDs. A cross-sectional study and an ecological study have been conducted. 361 women were recruited in obstetrics outpatient clinic at the CHU Ste-Justine for the first study and 152,392 pregnancies and babies were identified in the Quebec Pregnancy Registry, which results from the linkage of three administrative health care databases from Quebec (RAMQ, Med-Echo and ISQ) for the second study. Only 27% of the wowen recruited for the first study had periconceptional folic acid supplementation intake that was concordant with guideline. Concordance varied according to their health risk factors profile for NTD. Our ecological study showed that the annual prevalence of periconceptional folic acid use increased from 0.17% to 0.80% (p < 0,0001) from 1998 to 2008 and birth prevalence of major congenital malformations increased by 15% (3.35% to 3.87%, p < 0,0001) during the same period. Our findings highlight the fact that folic acid is not widely used by women of childbearing age, regardless of the dose. There is a need for new public health programs to encourange women to consume folic acid every day before and during pregnancy. Moreover, the use of high dose folic acid does not seem to be correlated with a decline in the prevalence of major congenital malformations, on a populational level.

During the last decade, electronic prescribing has been a point of focus in healthcare industry and is rapidly becoming a standard of practice. It has proven as an important element in improving the quality of patient care, mitigating or eliminating the phone calls back and forth from pharmacies to point of care/health centers. Many e-prescribing systems were developed and marketed but these usually were unsuccessful because of the lack of direct electronic connectivity to local pharmacies and the lack of up-to-date formulary information, clinical guidelines, health plans &amp; services among other reasons. Despite their benefits, the adoption and usage of electronic prescribing systems has been low. In some of the developing countries like Uganda, the problem is even worst. Due to lack of essential resources and manpower, healthcare services have significantly impacted on the productivity and quality of patient care.In an effort to improve, promote and maintain the quality of health services in rural settings of developing countries like Uganda, a high level design for e-prescribing system has been proposed. Design specifications for Electronic Prescribing Management System (EPMS) along with functional prototype are built based on ICT4MPOWER project requirements and previous research and publications in this area.Initially research began with Drug and Stock Management System and EPMS emerged as one of its essential components. In order to strengthen and establish connection between ongoing electronic health record system and drug and stock management development, EPMS component came into lime light. Mare prescription management is not enough to serve patient centric needs. Hence, clinical decision support has been introduced into e- prescribing system to improve the quality of prescribing decisions. In order to develop a patient-centric e-prescribing system that is self-evolving and self sustaining, it is important to update the clinical decision-support system, formularies &amp; guidelines on regular basis. In order to make it usable, it is required to formulate effective health plans and increase associations between pharmacies and other health organizational units. The principal benefit of introducing E-prescribing system into Electronic Health Record (EHR) System is to connect open ended systems to form a strong knowledge base for future. / ICT4MPOWER

Bakgrund: I Sverige finns 45 förlossningskliniker. Varje klinik har egna PM/riktlinjer för olika tillstånd och omhändertagande. De är framtagna för att underlätta arbetet och främja jämlik vård. Det finns både risker med att ge oxytocin och att avstå från det. Därför är det viktigt att åtgärden används på ett sätt som minimerar riskerna för mor och barn samt ökar sannolikheten för ett positivt förlossningsutfall.  Syfte:  Att kartlägga svenska förlossningsklinikers riktlinjer för värkstimulering med oxytocin under aktiv förlossning utifrån frågeställningarna: Är förlossningsklinikernas riktlinjer utformade enligt Nationella Mediciniska Indikationer och uppvisar riktlinjerna en god kvalitét enligt bedömningsinstrumentet Apprasial of Guidelines Research and Evaluation II (AGREE II). Metod: En kvantitativ studie med beskrivande och jämförande design. Resultat:  Resultatet grundar sig på samtliga förlossningskliniker riktlinjer för värkstimulering med oxytocin under aktiv förlossning. Jämförelsen mot Nationella Medicinska Indikationer visar på stora skillnader vad gäller innehållet i riktlinjerna. I 25 PM (69 %) saknas en eller flera delar av innehållet. Resultatet utifrån AGREE II visade att endast 20 PM (56%) kunde rekommenderas för användning.  Slutsats: Kvalitén på riktlinjerna varierar och de förlossningskliniker som följt Nationella Mediciniska Indikationer är också de som uppvisar bäst resultat enligt AGREE II. / Background: In Sweden there are 45 delivery wards. Every ward has their own guidelines for different conditions and their management. They are composed to relieve the work and promote equal care. There are risks of both administering oxytocin and to refrain from it. It is therefore important that the course of action taken is used in a way that minimizes the risk for both the mother and the child at the same time increasing the probability for a positive delivery outcome. Purpose: To map the Swedish delivery wards local guidelines in inducing delivery with oxytocin during active delivery in regards to the following issues: are the delivery wards guidelines formed according to National Medical Indication and do they uphold the high quality standard according to the assessment tool Appraisal of Guidelines Research and Evaluation II (AGREE II). Method: A quantitative study with descriptive and comparable design. Results: The result is based on all delivery wards local guidelines for inducing delivery with oxytocin during active delivery. In comparison to NMI there are large differences in the content of the guidelines. In 25 guidelines (69%) there were one or several parts of content missing. The result according to AGREE II showed that only 20 local guidelines (56%) could be recommended for clinical use. Conclusion: The quality of the local guidelines vary and the delivery wards that have followed National Medical Indication recommendations are also the ones that present the best results according to AGREE II.