Submitted by Caroline Xavier (caroline.xavier@pucrs.br) on 2017-06-30T17:23:45Z No. of bitstreams: 1 DIS_CYNTHIA_ROCHA_DULLIUS_PARCIAL.pdf: 1616329 bytes, checksum: b78ba61ceee893e19c9a37cda76e7f26 (MD5) / Approved for entry into archive by Caroline Xavier (caroline.xavier@pucrs.br) on 2017-06-30T17:23:52Z (GMT) No. of bitstreams: 1 DIS_CYNTHIA_ROCHA_DULLIUS_PARCIAL.pdf: 1616329 bytes, checksum: b78ba61ceee893e19c9a37cda76e7f26 (MD5) / Made available in DSpace on 2017-06-30T17:23:59Z (GMT). No. of bitstreams: 1 DIS_CYNTHIA_ROCHA_DULLIUS_PARCIAL.pdf: 1616329 bytes, checksum: b78ba61ceee893e19c9a37cda76e7f26 (MD5) Previous issue date: 2017-03-31 / Introduction: Respiratory infections are responsible for high morbidity and mortality in most countries. Streptococcus pneumoniae (pneumococcus) remains the main agent responsible for these infections, whether they are invasive or not. Invasive pneumococcal disease (IPD) is one in which pneumococcus is found in noble liquids, that is, previously sterile material. This study aimed to evaluate the microbiological characteristics of pneumococcus in patients admitted to a terciary hospital. Methods: A cross-sectional study with descriptive and analytical analysis, consisted of patients hospitalized at the S?o Lucas Hospital of PUCRS (HSL /PUCRS, Porto Alegre, RS) who had laboratory identification of Streptococcus pneumoniae in noble liquid from January 2005 to July 2016. Results: The majority of the population was male (58.6%) and had a mean age of 55 years (P25-75 31-71). The most frequent diagnostic was pneumonia and pneumococcus was more frequently recovered from blood culture. More than 25% of the studied population had some degree of known immunosuppression (25.3%). There was no difference in mortality when subdividing the population into having comorbidities and / or need for ICU/MV. The overall mortality of the sample was 31.1%. The most common serotypes were 19A, 3, 12F e 8. The theoretical vaccine coverage in the sample was 34.4% for the PPV23 and 50.5% for PCV13 and PPV23 associated. Conclusions: In this IPD sample, the most common serotypes were 19A, 3, 12F and 8, although it was not possible to relate them to a higher mortality ou need to ICU/MV. / Introdu??o: As infec??es respirat?rias s?o respons?veis por alta morbi-mortalidade na maioria dos pa?ses. O Streptococcus pneumoniae (pneumococo) segue sendo o principal agente destas infec??es, sendo elas invasivas ou n?o. Doen?a pneumoc?cica invasiva (DPI) ? aquela em que o pneumococo ? encontrado em l?quidos nobres, isto ?, material previamente est?ril. Este trabalho teve por objetivo avaliar as caracter?sticas microbiol?gicas do pneumococo em pacientes internados em hospital terci?rio. M?todos: Estudo transversal, com an?lise descritiva e anal?tica, realizado com pacientes internados no Hospital S?o Lucas da PUCRS (HSL/PUCRS, Porto Alegre, RS) que apresentaram identifica??o laboratorial de Streptococcus pneumoniae em l?quido nobre, de janeiro de 2005 at? julho de 2016. Resultados: Foram avaliadas 99 cepas de pneumococo. Os pacientes dos quais foram obtidas essas amostras eram em sua maioria do sexo masculino (58,6%) e com idade mediana de 55 anos (P25-75 31-71). O agravo mais frequente foi pneumonia e o pneumococo foi mais frequentemente recuperado em hemocultura. Mais de 25% da popula??o estudada tinha algum grau de imunossupress?o conhecida (25,3%). N?o houve diferen?a de mortalidade ao se subdividir a popula??o em comorbidades e/ ou necessidade de UTI/VM. A mortalidade global da amostra foi 31,1%. Os sorotipos mais comuns foram o 19A, 3, 12F e 8. A cobertura vacinal te?rica na amostra foi de 34,3% para PPV23 isoladamente e de 50,5% para a PCV13 e PPV23 associadas. Conclus?es: Nesta amostra de DPI, os sorotipos mais frequentes foram 19A, 3, 12F e 8, embora n?o tenha sido poss?vel relacionar com maior mortalidade ou necessidade de UTI/VM.

Submitted by PPG Gerontologia Biom?dica (geronbio@pucrs.br) on 2017-07-14T16:53:09Z No. of bitstreams: 1 NEUSA_MARIA_DE_OLIVIERA_CHARDOSIM_DIS.pdf: 1271158 bytes, checksum: 623f6cdc94a2edddc2c1886237153887 (MD5) / Rejected by Caroline Xavier (caroline.xavier@pucrs.br), reason: Devolvido devido a falta da capa institucional. on 2017-07-28T18:37:05Z (GMT) / Submitted by PPG Gerontologia Biom?dica (geronbio@pucrs.br) on 2017-07-31T16:40:16Z No. of bitstreams: 1 NEUSA_MARIA_DE_OLIVIERA_CHARDOSIM_DIS.pdf: 1323468 bytes, checksum: a556822f2b56df09e333d35a781b8af4 (MD5) / Approved for entry into archive by Caroline Xavier (caroline.xavier@pucrs.br) on 2017-08-03T18:58:25Z (GMT) No. of bitstreams: 1 NEUSA_MARIA_DE_OLIVIERA_CHARDOSIM_DIS.pdf: 1323468 bytes, checksum: a556822f2b56df09e333d35a781b8af4 (MD5) / Made available in DSpace on 2017-08-03T19:06:03Z (GMT). No. of bitstreams: 1 NEUSA_MARIA_DE_OLIVIERA_CHARDOSIM_DIS.pdf: 1323468 bytes, checksum: a556822f2b56df09e333d35a781b8af4 (MD5) Previous issue date: 2017-03-28 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior - CAPES / Parkinson's disease (PD) is a degenerative and progressive disease of the central nervous system, which is characterized by neuronal death in the substantia nigra, with consequent decrease of dopamine, leading to typical motor alterations. In addition to the motor symptoms, cognitive and behavioral changes occur, which have been shown to be a preponderant factor for the worsening of the patients' disease. It is a disease whose prevalence increases with age, reaching 1% in individuals over 60 years. With the increase in life expectancy, it is estimated that millions of people in the world will be carriers of PD. Thus, the main objective of this study was to investigate the relationship between personality factors, cognitive functioning and depressive and anxiety symptoms in the elderly with PD. In addition, it aimed to: a) characterize the cognitive functioning, personality factors and prevalence of depressive and anxiety symptoms in elderly with PD; B) to verify relationships among the factors of personality, age, schooling, depressive symptoms and of anxiety and cognitive performance; C) analyze whether personality factors are predictors of the cognitive functioning of elderly with PD. This study had a cross-sectional, correlational and exploratory design. The sample was recruited for convenience, consisting of 30 elderly people with PD, aged 60-86 years (M = 68.97; SD = 6.35). Participants responded to a Sociodemographic Data Sheet, the NEO-FFI-R, the Montreal Cognitive Assessment (MoCA), the Beta-III (matrix reasoning), the verbal phonemic fluency test (FAS) and semantics (Animals), the subtests digits span of the Wechsler Adult Intelligence Scale (WAIS-III) and the Boston Naming Test and the word list of the CERAD battery, the Geriatric Depression Scale (GDS-15) and the Anxiety Inventory of Beck (BAI). The elderly with PD presented impairments in the functions of verbal episodic memory (immediate recall, late recall and recognition) and executive functions (abstract reasoning and problem solving). Among the elderly evaluated, 43% had depressive symptoms and 27% had anxiety symptoms. Participants demonstrated low levels of neuroticism, extroversion and openness to experience, and high levels ofagreeableness and conscientiousness. The extroversion factor was positively correlated with executive functions (verbal fluency) and the openness to experience factor was positively correlated with verbal episodic memory (late recall). Together, extroversion and aperture factors have been shown to be the strongest predictors of the performance of elderly with PD in verbal episodic memory tasks (late recall). The extroversion factor only contributes to the performance of the elderly with PD in memory tasks (immediate recall and recognition) and executive functions (verbal phonemic and semantic fluency). It is concluded that the elderly with DP present memory impairment and executive functions. The extroversion factor is the factor that contributes most to the performance of the elderly with PD in memory tasks and executive functions. / A Doen?a de Parkinson (DP) ? uma doen?a degenerativa e progressiva do sistema nervoso central, que se caracteriza por morte neuronal na subst?ncia negra, com consequente diminui??o de dopamina, levando a altera??es motoras t?picas. Al?m dos sintomas motores, ocorrem altera??es cognitivas e comportamentais, que t?m se mostrado como um fator preponderante para o agravamento da doen?a dos pacientes. ? uma doen?a cuja preval?ncia aumenta com a idade, chegando a 1% em indiv?duos acima de 60 anos. Com o aumento da expectativa de vida, estima-se que milh?es de pessoas no mundo ser?o portadoras da DP. Assim, o presente estudo teve como principal objetivo investigar a rela??o entre fatores de personalidade, funcionamento cognitivo e sintomas depressivos e de ansiedade em idosos com a DP. Al?m disso, buscou: a) caracterizar o funcionamento cognitivo, os fatores de personalidade e a preval?ncia de sintomas depressivos e de ansiedade em idosos com DP; b) verificar rela??es entre os fatores de personalidade, idade, escolaridade, sintomatologia depressiva e de ansiedade e desempenho cognitivo; c) analisar se os fatores de personalidade s?o preditores do funcionamento cognitivo de idosos com DP. Este estudo teve um delineamento transversal, correlacional e explorat?rio. A amostra foi recrutada por conveni?ncia, sendo composta por 30 idosos com DP,com idades entre 60 a 86 anos (M=68,97; DP=6,35). Os participantes responderam a uma Ficha de dados sociodemogr?ficos,o NEO-FFI-R, o Montreal Cognitive Assessment (MoCA), o subteste racioc?nio matricial do Teste de Intelig?ncia n?o verbal (Beta-III), o Teste de Flu?ncia Verbal Fon?mica (FAS) e Sem?ntica (Animais), o subteste d?gitos da Escala de Intelig?ncia Wechsler para adultos (WAIS-III) e os subtestes lista de palavras e Teste de nomea??o de Boston da bateria CERAD, a Escala de Depress?o Geri?trica (GDS-15) e o Invent?rio de Ansiedade de Beck (BAI). Os idosos com DP apresentaram preju?zos nas fun??es de mem?ria epis?dica verbal (evoca??o imediata, tardia e reconhecimento) e fun??es executivas (racioc?nio abstrato e resolu??o de problemas). Dentre os idosos avaliados, 43% apresentaram sintomas depressivos e 27% sintomas de ansiedade. Os participantes demonstraram baixos n?veis de neuroticismo, de extrovers?o e abertura ? experi?ncia e altos n?veis de amabilidade e conscienciosidade. O fator extrovers?o correlacionou-se de maneira positiva com fun??es executivas (flu?ncia verbal) e o fator abertura a experi?ncia correlacionou-se positivamente com mem?ria epis?dica verbal (evoca??o tardia). Conjuntamente, os fatores extrovers?o e abertura demonstraram-se como os preditores mais fortes do desempenho de idosos com DP em tarefas de mem?ria epis?dica verbal (evoca??o tardia). O fator extrovers?o, unicamente, contribui para o desempenho de idosos com DP em tarefas de mem?ria (evoca??o imediata e reconhecimento) e em fun??es executivas (flu?ncia verbal fon?mica e sem?ntica). Conclui-se que idosos com DP apresentam preju?zos na mem?ria e fun??es executivas. O fator extrovers?o ? o fator que mais contribuiu para o desempenho de idosos com DP em tarefas de mem?ria e em fun??es executivas.

Submitted by PPG Pediatria e Sa?de da Crian?a (pediatria-pg@pucrs.br) on 2017-10-03T19:45:05Z No. of bitstreams: 1 TeseF?timaversaofinal.pdf: 880598 bytes, checksum: 689eb5cf56995aa9a6100e6827f43c4c (MD5) / Approved for entry into archive by Caroline Xavier (caroline.xavier@pucrs.br) on 2017-10-04T13:52:56Z (GMT) No. of bitstreams: 1 TeseF?timaversaofinal.pdf: 880598 bytes, checksum: 689eb5cf56995aa9a6100e6827f43c4c (MD5) / Made available in DSpace on 2017-10-04T13:56:23Z (GMT). No. of bitstreams: 1 TeseF?timaversaofinal.pdf: 880598 bytes, checksum: 689eb5cf56995aa9a6100e6827f43c4c (MD5) Previous issue date: 2017-03-22 / PROBOLSA / Introduction: Acute respiratory tract infections (ARTI) are one of the most important causes of mortality in children under 5 years old. In developed countries ARTI account for 20% of emergency consultations and 75% of antibiotic prescriptions. Children in attending day care are more prone to recurrence of respiratory infections. Bacterial immunostimulants, resulting from the chemical lysis of microorganisms associated with most respiratory tract infections, have been propagated as possibly useful intervention for prevention of recurrent respiratory infections. Objective: To analyze the effectiveness of OM-85 Broncho-vaxom (OM-85 BV) on the prevention of upper respiratory tract infections in healthy children attending preschool during the 6-month period. Methods: A randomized, double-blind, placebo controlled study was conducted in 54 healthy children aged between 6 months to 5 years attending in the School for Early Childhood Education between the months of April and September. Use of OM-85 BV for 3 months and observed for a further 3 months the following outcomes: upper respiratory tract infection, bronchopneumonia, other infections, use of antibiotics, emergency consultations, need for hospital stay, side effects of the medication. Results: Of the 54 children included, 57% were male. All completed the study and there were no significant differences between the groups. Of the 27 patients in group OM-85 BV, 19 (70,4%), attending daycare full-time and 16 (64,85%) half period, morning or evening. Breastfeeding was exclusive until 6 months in 6 patients (22,2%) on the OM-85 BV group and in 7 (25,9%) patients in the control group. Family history of smoking was positive in 11 (40,7%) patients in the OM-85 BV group and in 13 (48,1%) patients in the control group. Regarding the number of respiratory infections, the mean in the OM-85 BV group in the first 3 months was 0,92? 0,87 and in the placebo group was 0,74? 1,02 and in the 6 months was 1,62? 1,47 and 1,03?1,34, respectively. Antibiotic was used in 10 (37%) children of the OM-85BV group in the 3 months of treatment and in 13 (48,1%) of the placebo group, and in the 6 months of follow-up the use was 48,1% in both groups. The mean number of hospitalizations was very low in the period of the study. The mean number of emergency visits during the first 3 months was 0,81?1,21 in the OM-85 BV group and 1,29?1,48 in the placebo group and at 6 months was 1,77?1,80 in the OM-85 BV group and 2,03?1,76 in the placebo group. Conclusions: OM-85 BV was not effective as an intervention in daycare children with no history of IRR. No statistically significant difference was observed between the groups in the use of antibiotics, emergency consultations and hospitalizations. / Introdu??o: As infec??es agudas do trato respirat?rio est?o entre as causas mais importantes de mortalidade na faixa et?ria abaixo dos 5 anos, sendo, em pa?ses desenvolvidos, respons?veis por 20% das consultas nas emerg?ncias e 75% das prescri??es de antibi?ticos. Crian?as que frequentam creche s?o mais propensas ? recorr?ncia das infec??es respirat?rias. Os imunoestimulantes bacterianos, resultantes da lise qu?mica de microrganismos associados com a maioria das infec??es respirat?rias, t?m sido propagados como interven??o possivelmente ?til para a preven??o das infec??es respirat?rias recorrentes (IRR). Objetivo: Analisar a efic?cia do OM-85 Broncho Vaxom (OM-85 BV) na preven??o de infec??es respirat?rias do trato respirat?rio superior em crian?as h?gidas que frequentam pr?-escola, durante o per?odo de 6 meses. M?todos: Desenvolveu-se um estudo randomizado duplo cego placebo controlado em 54 crian?as previamente h?gidas, com idade entre 6 meses e 5 anos, que frequentavam a Escola de Educa??o Infantil entre os meses de abril e setembro. Usado OM-85 BV por 3 meses e observado por mais 3 meses os seguintes desfechos: presen?a de infec??o do trato respirat?rio superior, broncopneumonia, outras infec??es, uso de antibi?ticos, consultas na emerg?ncia, necessidade de interna??o hospitalar, dias de aus?ncia ? creche e efeitos colaterais da medica??o. Resultados: Das 54 crian?as inclu?das, 57% eram do sexo masculino. Todos completaram o estudo e n?o houve diferen?as significativas entre os grupos. Dos 27 pacientes do grupo OM-85 BV, 19 (70,4%), frequentavam a creche em turno integral e dos 27 pacientes do grupo controle, 16 (64,8%). O aleitamento materno, foi exclusivo at? o 6? m?s em 6 (22,2%) pacientes do grupo OM-85 BV em 7 (25,9%) pacientes do grupo controle. Quanto ? hist?ria familiar de fumo, foi positiva em 11 (40,7%) pacientes do grupo OM-85 BV e em 13 (48,1%) pacientes do grupo controle. Em rela??o ao n?mero de infec??es respirat?rias, a m?dia no grupo OM-85 BV nos primeiros 3 meses foi 0,92?0,87 e no grupo placebo foi 0,74?1,02 e nos 6 meses foi 1,62?1,47 e 1,03?1,34, respectivamente. Antibi?tico foi usado em 10 (37%) crian?as do grupo OM-85BV nos 3 meses de tratamento e em 13 (48,1%) do grupo placebo, j? nos 6 meses de acompanhamento o uso foi de 48,1% nos dois grupos. A m?dia de interna??es foi muito baixa no per?odo estudado. A m?dia de consultas na emerg?ncia nos primeiros 3 meses foi de 0,81?1,21 no grupo OM-85 BV e 1,29?1,48 no grupo placebo e nos 6 meses foi de 1,77?1,80 no grupo OM-85 BV e 2,03?1,76 no grupo placebo. Conclus?es: OM-85 BV n?o foi eficaz como interven??o em crian?as que frequentam creche, sem hist?ria de IRR. N?o houve diferen?a estatisticamente significativa no uso de antibi?ticos, consultas na emerg?ncia e interna??es hospitalares

Submitted by PPG Gerontologia Biom?dica (geronbio@pucrs.br) on 2017-10-02T11:32:32Z No. of bitstreams: 1 OLIVEIRA_CHARLENE_BRITO_TESE.pdf: 3750193 bytes, checksum: a5e5b863e98d3354e5af371cd1b063c2 (MD5) / Rejected by Caroline Xavier (caroline.xavier@pucrs.br), reason: Devolvido devido ? falta de capa institucional no arquivo PDF. on 2017-10-02T12:15:52Z (GMT) / Submitted by PPG Gerontologia Biom?dica (geronbio@pucrs.br) on 2017-10-24T16:21:20Z No. of bitstreams: 1 OLIVEIRA_CHARLENE_BRITO_TESE.pdf: 5702628 bytes, checksum: 500180262884e19627b8da8d821de3da (MD5) / Approved for entry into archive by Caroline Xavier (caroline.xavier@pucrs.br) on 2017-10-26T16:20:49Z (GMT) No. of bitstreams: 1 OLIVEIRA_CHARLENE_BRITO_TESE.pdf: 5702628 bytes, checksum: 500180262884e19627b8da8d821de3da (MD5) / Made available in DSpace on 2017-10-26T16:26:50Z (GMT). No. of bitstreams: 1 OLIVEIRA_CHARLENE_BRITO_TESE.pdf: 5702628 bytes, checksum: 500180262884e19627b8da8d821de3da (MD5) Previous issue date: 2017-03-03 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior - CAPES / Importance: The efficacy of combined body suspension with tilting exercises (Chordata Method) in Parkinson?s disease (PD) is unclear. Objective: Design a clinical study to assess the efficacy of body suspension with tilting exercises on functional and quality of life outcomes in PD. Design, Setting, and Participants: This is an assessor-blinded, randomized and controlled clinical trial. A total of 48 subjects with moderate PD were recruited from the Neurological Service of S?o Lucas Hospital, PUCRS, Brazil. Recruitment took place between September 2015 and May 2016. The entire protocol study lasted 16 weeks, with 8 weeks of exercise protocol and 8 weeks of follow-up. Interventions: Subjects were randomly assigned to either body suspension with tilting exercises (intervention group) or stretching exercises (control group). Main Outcomes and Measures: The primary outcome was the Timed Up and Go test at the 8th week. Secondary outcomes were Berg Balance Scale (BBS); Functional Reach Test (FRT); Unified Parkinson?s Disease Rating Scale (UPDRS) and Parkinson?s Disease Questionnaire (PDQ-39). These measures were assessed at baseline (before trial entry) and then at the 8th (end of exercise protocols) and 16th weeks (8 weeks of follow-up) after randomization. Results: Of the 48 subjects randomized in the study 20 received the intervention (71.3?6.3 years old) and 20 were controls (66.7?6.4 years old). Eight of them were lost during the trial (four per group). Analysis of co-variance, with adjustment for baseline measurement, revealed a between-group difference in the Timed Up and Go test at 8th week [CI95% difference of -4.90 (-5.80 a -4.00), p<0.0001] and in the follow-up [CI95% difference of -4.94 sec (-5.82 to -4.06), p<0.0001], which was our primary outcome. Significant between-groups differences were also found for all secondary outcomes (BBS, UPDRS-III, FRT, and PDQ-39) at 8th week and follow-up (16th week) assessments. Conclusions and relevance: We suggest the body suspension with tilting exercises protocol (the Chordata Method) improves functionality and quality of life in subjects with moderate PD. This evidence supports the Chordata method appears to be a new effective therapeutic option to treat Parkinson-related mobility and balance dysfunctions. / Import?ncia: A efic?cia da utiliza??o de exerc?cios de suspens?o e pendula??o corporal (m?todo Chordata) para o tratamento de sujeitos com a Doen?a de Parkinson ainda n?o foi testada. Objetivo: Realizar um estudo cl?nico para avaliar a efic?cia de um programa de exerc?cios de suspens?o e pendula??o corporal sobre a funcionalidade e qualidade de vida de sujeitos portadores da doen?a de Parkinson. Delineamento, M?todo e Participantes: Trata-se de um ensaio cl?nico, controlado e randomizado, com avaliador de desfecho alheio aos grupos experimentais. Um total de 48 sujeitos com diagn?stico m?dico de doen?a de Parkinson, de est?gio leve ? moderado, foram recrutados a partir do Servi?o de Neurologia do Hospital S?o Lucas da PUCRS, Brasil. O recrutamento ocorreu entre Setembro de 2015 e Maio de 2016. O protocol do estudo teve a dura??o de 16 semanas, sendo 8 semanas de pr?tica dos exerc?cios propostos, com iguais 8 semanas de seguimento (follow-up). Interven??o: Os sujeitos foram randomizados nos grupos interven??o (suspens?o e pendula??o corporal) e controle (alongamentos de grandes grupos musculares). Desfechos principais e medidas: O desfecho prim?rio do presente estudo foi o teste do Timed Up and Go ao final do protocolo de treinamento (8 semanas). Os desfechos secund?rios foram a Escala de Equil?brio de Berg (EEB); o teste do Alcance Funcional (TAF); a Escala Unificada da Doen?a de Parkinson, sess?o III (UPDRS-III) e o Question?rio de Qualidade de Vida na Doen?a de Parkinson (PDQ-39). Estes desfechos foram avalaidos nos momentos pr?-interven??o, ap?s, ao t?rmino do protocol de exerc?cios (8 semanas) e no per?odo de seguimento (16 semanas ap?s a randomiza??o). Resultados: De um total de 48 sujeitos randomizados, 20 participaram do grupo interven??o (71,3?6,3 anos de idade) e 20 do grupo controle (66,7?6,4 anos de idade). Oito sujeitos foram perdidos durante a execu??o do estudo (quarto em cada um dos grupos). A An?lise de co-vari?ncia, com ajuste para os dados basais, revelou uma diferen?a entre-grupos no teste do Timed Up and Go ao t?rmino do protocolo de exerc?cios (8 semanas) [diferen?a IC95%: -4,90 (-5,80 a -4,00), p<0,0001] e na avalia??o de seguimento [diferen?a IC95%: -4.94 sec (-5,82 to -4,06), p<0.0001], teste este estabelecido como o desfecho prim?rio. Diferen?as significativas tamb?m foram encontradas para todos os desfechos secund?rios (EEB, UPDRS-III, TAF e PDQ-39) em ambas as avalia??es p?s-interven??o (8 e 16 semanas ap?s a randimiza??o). Conclus?es e relev?ncia: Nossos resultados sugerem que os exerc?cios de suspens?o e pendula??o corporal s?o capazes de melhorar a funcionalidade e a qualidade de vida de sujeitos com a doen?a de Parkinson, em est?gio moderado. Esta evid?ncia suporta que o m?todo Chordata parece ser uma nova e efetiva interven??o terap?utica para o tratamento das desordens de mobilidade e equil?brio associadas ? doen?a de Parkinson.

Submitted by PPG Pediatria e Sa?de da Crian?a (pediatria-pg@pucrs.br) on 2018-01-02T16:51:55Z No. of bitstreams: 1 Disserta??o Mestrado Marilisa.pdf: 905969 bytes, checksum: 348718dad9108301470f73e80e214e5c (MD5) / Approved for entry into archive by Caroline Xavier (caroline.xavier@pucrs.br) on 2018-01-24T12:31:32Z (GMT) No. of bitstreams: 1 Disserta??o Mestrado Marilisa.pdf: 905969 bytes, checksum: 348718dad9108301470f73e80e214e5c (MD5) / Made available in DSpace on 2018-01-24T12:33:57Z (GMT). No. of bitstreams: 1 Disserta??o Mestrado Marilisa.pdf: 905969 bytes, checksum: 348718dad9108301470f73e80e214e5c (MD5) Previous issue date: 2017-03-03 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior - CAPES / Cystic fibrosis (CF) has long been described as a fatal genetic disease. Currently, improvement in the care of these patients contributes to longer survival and thereby allows the observation of other symptoms related to mutations of the cystic fibrosis transmembrane chloride regulator (CFTR) gene, responsible for the disease. Although pulmonary disease continues to be the leading cause of morbidity and mortality, CF also requires that attention be given to manifestations of the disease in other organs, such as liver disease. CF-associated liver disease (CFLD) can be considered an independent risk factor for mortality and lung transplantation. The major challenge is to diagnose CFLD, because the changes may remain asymptomatic until advanced stages of the disease. There is currently no single test that is sensitive and specific enough to assess liver function, and early diagnosis of CFLD requires a combination of regular clinical examination, biochemical tests, and imaging studies. There are high expectations for noninvasive tests that are harmless to patients and can be easily repeated and compared in order to detect changes as early as possible. Imaging techniques have improved significantly over the past decade and new technologies are being incorporated into clinical practice. Ultrasonography (US), computed tomography and magnetic resonance imaging (MRI) are the main imaging modalities currently used for examination, but new MRI-based techniques have acquired great importance. Thus, it would be desirable to develop a more accurate method than US, which is the most widely used routine examination, as well as the ultrasound scoring system described by Williams et al in 1995 and used so far. This study aimed to describe possible MRI abnormalities in children with CF and correlate them with US findings, particularly in relation to parameters of parenchyma, border, and liver fibrosis. Methods: Patients with a diagnosis of CF underwent clinical examination, anthropometric measurements, US, and MRI. MRI was performed without sedation or contrast. The liver was evaluated using the scoring system described by Williams et al on US and MRI images. Other MRI features were also analyzed, including degenerative nodules, atrophy of the right hepatic lobe, and posterior notch sign of the hepatic lobe. Results: The US and MRI findings of 20 patients were analyzed. Patient age ranged from 8 to 19 years. Five patients showed US abnormalities with an ultrasound score greater than 3, 4 patients with a score of 7, and 1 patient with a score of 9. When the Williams scoring criteria were applied to MRI, 5 patients were evaluated as having a score of 9. US did not assess liver fibrosis in the same way as MRI. In the US evaluation, 4 patients received a score of 1 for this parameter, while in the MRI evaluation all patients received the maximum score. MRI revealed 4 patients with atrophy of the right hepatic lobe, 3 patients with degenerative nodules, and 2 patients with esophageal varices. Four patients (80%) showed the posterior notch sign of the hepatic lobe. Conclusion: Although there was a good correlation between US and MRI, MRI performed better than US in the assessment of liver fibrosis. The Williams scoring system can also be applied to hepatic MRI. Thus, MRI stands out as a noninvasive method that can provide further information related to CFLD, contributing to the overall assessment of patients with CF. / A fibrose c?stica (FC) foi por muito tempo descrita como uma doen?a gen?tica fatal. Atualmente, a melhora nos cuidados de sa?de destes pacientes possibilitou uma maior sobrevida e assim a observa??o de outras sintomatologias relacionadas ? muta??o do gene CFTR (cystic fibrosis transmembrane chloride regulator), respons?vel pela doen?a. Apesar da doen?a pulmonar continuar sendo a principal causa de morbidade e mortalidade, a FC exige aten??o tamb?m para manifesta??es de doen?a em outros ?rg?os, como o caso da doen?a hep?tica. A doen?a hep?tica associada ? FC (DHFC) pode ser considerada um fator de risco independente para a mortalidade e transplante pulmonar. O grande desafio ? o seu diagn?stico, pois suas altera??es podem permanecer assintom?ticas at? est?gios avan?ados da doen?a. N?o h? dispon?vel um teste que seja sens?vel e espec?fico para avaliar a fun??o hep?tica, o diagn?stico precoce da DHFC requer o conjunto de exame cl?nico regular, exames de bioqu?mica e de imagem. ? grande a expectativa por exames n?o invasivos que sejam in?cuos para o paciente e possam ser facilmente repetidos e comparados para a busca de altera??es o mais precoce poss?vel. As t?cnicas de imagem t?m melhorado significativamente na ?ltima d?cada e as novas tecnologias est?o come?ando a entrar na pr?tica cl?nica. Ultrassonografia (US), tomografia computadorizada e resson?ncia magn?tica (RM) s?o as principais modalidades usadas atualmente, mas novas t?cnicas baseadas em RM est?o em destaque. Desta forma, seria desej?vel desenvolver uma metodologia mais acurada que a US que ? o exame rotineiramente mais difundido, assim como o escore ultrassonogr?fico descrito por Williams et al em 1995, utilizado at? ent?o. Nosso objetivo ? descrever as poss?veis altera??es encontradas na RM em crian?as com FC e correlacionar com os achados da US, principalmente em rela??o aos par?metros de par?nquima, borda e fibrose hep?tica. M?todos: Pacientes com diagn?stico de fibrose c?stica realizaram avalia??o cl?nica, antropom?trica, exames de ultrassonografia e resson?ncia magn?tica. Os exames de resson?ncia magn?tica foram realizados sem seda??o e sem contraste. O f?gado foi avaliado segundo o escore descrito por Williams et al na ultrassonografia e na resson?ncia magn?tica. Foram analisados ainda outros diferentes aspectos na RM entre eles: n?dulos degenerativos, atrofia do lobo hep?tico direito, o sinal do entalhe posterior do lobo hep?tico. Resultados: Os exames de vinte pacientes foram analisadas, os participantes do estudo tinham idade entre 8 e 19 anos. Cinco pacientes apresentaram exame de US alterado com escore ultrassonogr?fico maior que 3, quatro pacientes com escore 7 e um com escore 9. Ao aplicar os crit?rios do escore de Williams na resson?ncia magn?tica, os 5 pacientes foram avaliados com escore 9. A ultrassonografia n?o pode avaliar a fibrose hep?tica da mesma forma que a resson?ncia, na US quatro pacientes receberam pontua??o 1 para o par?metro, j? na RM todos receberam pontua??o m?xima. Na RM, foram identificados quatro pacientes com atrofia do lobo hep?tico direito, tr?s pacientes com n?dulos degenerativos e 2 pacientes com varizes esof?gicas. Quatro pacientes (80%) apresentaram o sinal do entalhe posterior do lobo hep?tico direito. Conclus?o: Existe uma boa correla??o entre US e RM, por?m a RM teve melhor desempenho na avalia??o da fibrose hep?tica. O escore de Williams tamb?m pode ser aplicado para an?lise hep?tica pela RM. Assim a RM se destaca como um m?todo n?o invasivo que nos fornecer ainda outras informa??es relacionadas com a DHFC que contribuem na avali??o global do paciente com FC.

Submitted by PPG Biologia Celular e Molecular (bcm@pucrs.br) on 2018-04-06T17:32:47Z No. of bitstreams: 1 VANESSA_KAPPEL_DASILVA_TES.pdf: 5900313 bytes, checksum: 98206f797d5710ed04b0cd1d6529092e (MD5) / Approved for entry into archive by Caroline Xavier (caroline.xavier@pucrs.br) on 2018-04-16T19:58:40Z (GMT) No. of bitstreams: 1 VANESSA_KAPPEL_DASILVA_TES.pdf: 5900313 bytes, checksum: 98206f797d5710ed04b0cd1d6529092e (MD5) / Made available in DSpace on 2018-04-16T20:04:27Z (GMT). No. of bitstreams: 1 VANESSA_KAPPEL_DASILVA_TES.pdf: 5900313 bytes, checksum: 98206f797d5710ed04b0cd1d6529092e (MD5) Previous issue date: 2018-03-07 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior - CAPES / Brain iron accumulation has been observed both in normal aging and in many neurodegenerative diseases. In previous studies, we have described that brain iron overload results in persistent memory deficits, accompanied by oxidative stress. The high metabolic rate of the nervous system makes mitochondria essential for nerve cells. These organelles control iron homeostasis in its interior and the management of reactive oxygen species. When deregulation in these activities occurs, mitochondrial functioning is compromised, resulting in failures in the energy supply mainly for the synapses. Inadequate functioning of neural circuits may culminate in the activation of cell death pathways, a feature strongly associated with neurodegenerative diseases. In the present study we analyzed the effects of neonatal iron overload on complex I deletions in the mitochondrial DNA ; on methylation and hydroxymethylation of mitochondrial DNA; on mitochondrial proteins involved on iron homeostasis, on the enzymatic activity of Succinate Dehydrogenase and Creatine Kinase, enzymes involved in the cells energy supply; and on proteins involved in apoptotic pathways, such as Caspase 8, Caspase 9, Caspase 3, Cytochrome c, APAF1, and PARP in the hippocampus of adult rats. In addition, we investigated the effects of cannabidiol (CBD), the main non-psychotropic component of Cannabis sativa, in reversing iron-induced effects on all parameters analyzed. Male rats received vehicle or iron carbonyl (30 mg / kg) from the 12th to the 14th postnatal day and were treated with vehicle or CBD (10mg / kg) for 14 days in adulthood. Iron treatment induced increased deletions of mitochondrial DNA and expression of proteins involved in apoptosis, while induced reductions of methylation and hydroxymethylation, enzymatic activity and mitochondrial ferritin, an iron storage protein. CBD reversed iron-induced effects, recovering hydroxymethylation levels, mitochondrial ferritin, Succinate dehydrogenase activity, apoptotic proteins Caspase 3, Caspase 9, PARP and APAF1 at levels comparable to controls. These results suggest that iron can affect mechanisms of mitochondrial functioning and trigger cell death pathways by apoptosis. The reversal of some of these effects by CBD indicates its neuroprotective potential. / O ac?mulo de ferro no c?rebro tem sido observado tanto no envelhecimento normal quanto em muitas doen?as neurodegenerativas. Nossos estudos anteriores mostraram que a sobrecarga de ferro cerebral resulta em d?ficits de mem?ria persistentes, acompanhados por estresse oxidativo. A elevada taxa metab?lica do sistema nervoso torna as mitoc?ndrias essenciais para c?lulas nervosas. Essas organelas t?m como fun??o o controle da homeostasia do ferro em seu interior e o gerenciamento das esp?cies reativas de oxig?nio. Uma vez que ocorre desregula??o nessas atividades, o funcionamento das mitoc?ndrias fica comprometido, resultando em falhas no aporte energ?tico principalmente para as sinapses. O funcionamento inadequado de circuitos neurais pode culminar na ativa??o de vias de morte celular, uma caracter?stica bastante associada ?s doen?as neurodegenerativas. No presente trabalho analisamos os efeitos da sobrecarga de ferro neonatal sobre as dele??es no complexo I do DNA mitocondrial; sobre os mecanismos de metila??o e hidroximetila??o do DNA mitocondrial; sobre prote?nas envolvidas no metabolismo de ferro mitocondrial (Ferritina mitocondrial e Mitoferrina 2), sobre a atividade enzim?tica da Succinato desidrogenase e Creatina quinase, envolvidas no aporte energ?tico para as c?lulas; e sobre prote?nas envolvidas nas vias apopt?ticas, como a Caspase 8, Caspase 9, Caspase 3, Citocromo c, APAF1 e PARP em hipocampos de ratos adultos. Al?m disso, investigamos os efeitos do canabidiol (CBD), principal componente n?o psicotr?pico da Cannabis sativa, na revers?o dos efeitos induzidos pelo ferro sobre todos os par?metros analisados. Ratos machos receberam ve?culo ou ferro carbonila (30 mg/kg) do 12? ao 14? dia p?s-natal e na idade adulta foram tratados com ve?culo ou CBD (10 mg/kg) durante 14 dias. O tratamento com ferro induziu o aumento das dele??es do DNA mitocondrial e das prote?nas envolvidas na via intr?nseca da apoptose, enquanto induziu a redu??o de metila??o e hidroximetila??o no DNA mitocondrial, bem como da atividade enzim?tica e da ferritina mitocondrial, prote?na de armazenamento de ferro. O CBD reverteu os efeitos induzidos pelo ferro, recuperando os n?veis de hidroximetila??o, de ferritina mitocondrial, da atividade da Succinato dehidrogenase, e das prote?nas apopt?ticas Caspase 3, Caspase 9, PARP e APAF1 a n?veis compar?veis com o controle. Os resultados sugerem que o ferro pode afetar mecanismos de funcionamento mitocondrial e desencadear vias de morte celular por apoptose. A revers?o de alguns desses efeitos pelo CBD indica o seu potencial neuroprotetor.

Submitted by PPG Hist?ria (historia-pg@pucrs.br) on 2018-04-11T18:28:07Z No. of bitstreams: 1 TESE DE DOUTORADO HENRIQUE HELMS - final.pdf: 8241824 bytes, checksum: 9119bc635493fb610f1105e4d59cdce4 (MD5) / Approved for entry into archive by Caroline Xavier (caroline.xavier@pucrs.br) on 2018-04-26T17:08:29Z (GMT) No. of bitstreams: 1 TESE DE DOUTORADO HENRIQUE HELMS - final.pdf: 8241824 bytes, checksum: 9119bc635493fb610f1105e4d59cdce4 (MD5) / Made available in DSpace on 2018-04-26T17:11:21Z (GMT). No. of bitstreams: 1 TESE DE DOUTORADO HENRIQUE HELMS - final.pdf: 8241824 bytes, checksum: 9119bc635493fb610f1105e4d59cdce4 (MD5) Previous issue date: 2018-03-26 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior - CAPES / The air transport model has been consolidated as one of the most important economic markets in the past decades. The growing need for travelling more and more to farther regions around the globe has boosted the aeronautical industry in a significant way. However, the transportation of humans also entails the transportation of undesirable viruses and diseases. This study proposes the analysis of the influence of air transport in the spread of these viruses. In order to do so, we conduct a historical review on the evolution of some of the most impactful outbreaks ever experienced, focusing on the H1N1(2009) and on the Zika (2015-2016) epidemics. Through this analysis, we can clearly demonstrate that the growth in the air market - illustrated by larger aircraft, more locations being linked, and more operational technology, impact on more people flying and, consequently, more diseases being spread. Despite the efforts on behalf of aviation and health authorities and the use of technology, there is the need for more studies and research to develop strategies that can mitigate these consequences. / O transporte a?reo consolidou-se como um dos mercados de maior import?ncia econ?mica nas ?ltimas d?cadas. A necessidade de deslocamentos a pontos mais distantes e em maior frequ?ncia tem impulsionado a ind?stria aeron?utica de forma cont?nua e significativa. No entanto, sabemos que o transporte de seres humanos tamb?m acarreta o transporte de doen?as e v?rus n?o desej?veis. O presente estudo ? uma an?lise historiogr?fica da influ?ncia do transporte a?reo na dissemina??o de doen?as. Para isso, conduzimos uma revis?o hist?rica sobre a evolu??o de algumas das maiores epidemias j? vividas, concentrando um foco maior na gripe A H1N1 (2009) e de Zika (2015-2016). A partir desta an?lise, podemos constatar que o crescimento do transporte aeron?utico ? evidenciado atrav?s de aeronaves maiores, mais localidades sendo acessadas, maior tecnologia operacional, impactam em maior quantidade de pessoas voando e, consequentemente, maior facilidade de dissemina??o de doen?as. Apesar dos esfor?os por parte das autoridades sanit?rias e aeron?uticas e da utiliza??o de tecnologias pertinentes, acredita-se que h? a necessidade de mais estudos e pesquisas para o desenvolvimento de estrat?gias que possam mitigar tais consequ?ncias.

Submitted by PPG Medicina e Ci?ncias da Sa?de (medicina-pg@pucrs.br) on 2018-06-12T14:01:32Z No. of bitstreams: 1 EVANDRA_DURAYSKI.pdf: 1831041 bytes, checksum: 14177d40991ac101fe309c07dd96d0a7 (MD5) / Approved for entry into archive by Sheila Dias (sheila.dias@pucrs.br) on 2018-06-22T18:42:06Z (GMT) No. of bitstreams: 1 EVANDRA_DURAYSKI.pdf: 1831041 bytes, checksum: 14177d40991ac101fe309c07dd96d0a7 (MD5) / Made available in DSpace on 2018-06-22T18:51:12Z (GMT). No. of bitstreams: 1 EVANDRA_DURAYSKI.pdf: 1831041 bytes, checksum: 14177d40991ac101fe309c07dd96d0a7 (MD5) Previous issue date: 2018-03-07 / Conselho Nacional de Pesquisa e Desenvolvimento Cient?fico e Tecnol?gico - CNPq / Introduction: Crohn's disease (CD) is an idiopathic inflammatory bowel disease, which mainly affects the terminal ileum A biopsy colonoscopy with regard to the gold standard in the assessment of disease and the area of education costly and with anesthetic risks. Noninvasive methods of evaluation such as magnetic resonance enterography (MRE) have been developed in the last decade. Evaluation systems such as the magnetic resonance index of activity (MaRIA) and Clermont score are used in clinical studies to quantify inflammation in patients with CD. A diffusion-weighted magnetic resonance imaging (DWI) evaluates a restitution of the water molecules in the tissues. Studies have shown a correlation between a restriction of diffusion on the wall of the intestine with inflammation. However, few studies with MRE of 3 Tesla support analysis a apparent diffusion coefficient (ADC) correlactionan in inflammatory proces in the terminal ileum. Purpose: To determine the applicability of the sequence DWI in 3 Tesla MRE in the identification of inflammatory signs in the distal ileum in patients with Crohn?s disease. Materials and Methods: We retrospectively studied 38 individuals with CD, who underwent MRE between March 2014 to september 2017 and had an anatomopathological and endoscopic evaluation in the distal ileum. The following variables were evaluated: diffusion (DWI), quantitative ADC, wall thickening, intramural edema, ulcerations, stricture, segmental mural hyperenhancement, relativo contrast enchancement (RCE), MaRIA and Clermont score. Results: The mean duration of the disease was 7 ? 5 years, 19 patients (50%) were male. Eighteen patients (47%) had active inflammatory disease and twenthy (53%) had disease in remission in the terminal ileum. Patients with active inflammatory disease in the distal ileum had a greater restriction on DWI, intramural edema, wall thickening, MaRIA and Clermont score, when compared to the group of patients without inflammation. The correlation between MaRIA and Clermont score (r = 0.975) was strong. The Kappa coefficient of interobserver agreement was excellent for the MaRIA, Clermont score and restriction DWI, moderate for ADC and weak for RCE. The best cut-off point in this study for the inflammation identified by the colonoscopy for the ADC was 2.1x103mm2/s, with sensitivity of 88.8% and specificity of 95.0%. The DWI presented accuracy of 89.4%, sensitivity of 88.9% and specificity of 90.0% in relation to inflammation identified by colonoscopy. Conclusion: The quantitative values of ADC have a good sensitivity in detecting inflammation at colonoscopy. Analysis of the diffusion sequence of good accuracy in the detection of ileum inflammmation in patients with Crohn's disease. However, when in association with intramural enhancement, edema and wall thickening it has a strong correlation with severe inflammation identified at colonoscopy. / Introdu??o: A Doen?a de Crohn (DC) ? uma doen?a inflamat?ria intestinal idiop?tica, que acomete principalmente o ?leo terminal. A colonoscopia seguida de bi?psia, apesar de ser considerada o padr?o-ouro na avalia??o de doen?a ativa, ? uma ferramenta de monitoramento onerosa e com riscos anest?sicos. M?todos de avalia??o n?o invasivos, como a enterorresson?ncia (Entero-RM), foram desenvolvidos na ?ltima d?cada. Os sistema de pontua??o como o ?ndice MaRIA e escore de Clermont s?o utilizados em estudos cl?nicos para quantificar a inflama??o em pacientes com DC. A difus?o ? uma sequ?ncia da resson?ncia que avalia a restri??o das m?leculas de ?gua nos tecidos. Estudos demonstraram correla??o entre a restri??o da difus?o na parede do intestino com a inflama??o. Entretanto, poucos estudos com a Entero-RM de 3 Tesla avaliaram se a an?lise quantitativa do ADC (coeficiente de difus?o aparente) teria sensibilidade na avalia??o de processo inflamat?rio no ?leo terminal. Objetivos: Determinar a aplicabilidade da sequ?ncia de Difus?o na Entero-RM de 3 Tesla na identifica??o de sinais inflamat?rios no ?leo distal em pacientes com DC. Materiais e M?todos: Foram estudados retrospectivamente 38 indiv?duos com DC, submetidos a entero-RM no per?odo mar?o de 2014 a setembro de 2017 e que tinham avalia??o anatomopatol?gica e endosc?pica no ?leo distal. Foram avaliadas a seguintes vari?veis: difus?o, ADC quantitativo, espessamento parietal, edema, ulcera??es, estreitamento, realce pelo contraste, realce relativo ao contraste (RCE), ?ndice MaRIA e escore de Clermont. Resultados: A m?dia da dura??o da doen?a foi de 7 ? 5 anos, 19 pacientes (50%) eram do sexo masculino. Dezoito pacientes (47%) tinham doen?a inflamat?ria ativa e 20 (53%) tinham doen?a em remiss?o no ?leo terminal. Os pacientes que apresentavam doen?a inflamat?ria ativa no ?leo distal tiveram maior restri??o a difus?o, edema na mucosa, espessamento parietal, ?ndice de MaRIA e maior valor no escore de Clermont, quando comparados com o grupo de pacientes sem inflama??o. Foi forte a correla??o entre o ?ndice MaRIA com o escore de Clermont (r=0,975). O Coeficiente Kappa de concord?ncia interobservador foi excelente para ?ndice MaRIA, escore de Clermont e restri??o a difus?o, moderada para ADC e fraca para o RCE. O melhor ponto de corte neste estudo para a inflama??o identificada pela colonoscopia para o ADC foi de 2,1x10-3mm2/s, com sensibilidade de 88,8% e especificidade de 95,0%. A sequ?ncia da difus?o apresentou acur?cia de 89,4%, sensibilidade de 88,9% e especificidade de 90,0% em rela??o a inflama??o identificada pela colonoscopia. Conclus?o: Os valores quantitativos do ADC t?m uma boa sensibilidade na detec??o de inflama??o na colonoscopia. A an?lise da sequ?ncia da difus?o tem boa acur?cia na detec??o de segmentos intestinais ileais inflamados em pacientes com doen?a de Crohn. Em suma, quando a restri??o a difus?o tem associa??o com realce, edema e espessura da parede, aumenta a correla??o com a inflama??o severa identificada na colonoscopia.

Submitted by Jadson Francisco de Jesus SILVA (jadson@uefs.br) on 2017-02-21T00:27:53Z No. of bitstreams: 1 Disserta??o Queilite.pdf: 1429874 bytes, checksum: 741a01c64aff635e85c316496786af33 (MD5) / Made available in DSpace on 2017-02-21T00:27:53Z (GMT). No. of bitstreams: 1 Disserta??o Queilite.pdf: 1429874 bytes, checksum: 741a01c64aff635e85c316496786af33 (MD5) Previous issue date: 2016-09-22 / Funda??o de Amparo ? Pesquisa do Estado da Bahia - FAPEB / Actinic cheilitis is a potentially malignant disorder of inflammatory nature, which affects the lip, mostly the lower lip. The lesion is caused by prolonged and excessive exposure to sunlight, occurring mainly in white males that perform activities exposed to the sun. The aim of this study was estimate the prevalence of actinic cheilitis and identify the factors associated with this lesion for construction workers who worked on construction sites in the city of Feira de Santana, Bahia, in the year of 2015. This work is an epidemiological cross-sectional survey. The study sample consisted of 319 construction workers of both genders. For data collection, interviews were conducted to obtain demographic information, professional occupation, lifestyle, and the use of photoprotection measures. In addition, all employees underwent oral examination and procedures for the diagnosis of actinic cheilitis. The workers were mostly male (99.4%), black (48,3%), and mean age of 37 years. Most were from urban areas (51.7%), married (36,7%), and schooling level was incomplete primary education (50,2%). The average monthly income was R$1,139.28.The prevalence of actinic cheilitis among study participants was 13.5% (CI 95%: 10,2 ? 17,7). An association was found between the presence of the lesion and 1) white skin color (PR=5,44; CI 95%: 3,37-8,80), 2) age greater than or equal to 37 years (PR=1,98; CI 95%:1,06-3,69), 3) working time in construction greater than or equal to 10 years (PR = 2,26; CI 95%: 1,29-3,27). A high prevalence of actinic cheilitis was observed in construction workers, indicating the need for educational and preventive measures on occupational risk of solar radiation and other risk factors for oral cancer in this population. / A queilite act?nica ? uma desordem potencialmente maligna de car?ter inflamat?rio, que acomete o l?bio, principalmente inferior. A les?o ? causada pela exposi??o prolongada e excessiva aos raios solares, ocorrendo majoritariamente em indiv?duos do sexo masculino, de cor branca e que exercem atividades expostos ao sol. O objetivo principal deste estudo foi estimar a preval?ncia de queilite act?nica e identificar os fatores associados a esta les?o em trabalhadores da constru??o civil que atuaram em canteiros de obras do Munic?pio de Feira de Santana, Bahia, no ano 2015. Trata-se de uma pesquisa epidemiol?gica do tipo transversal. A amostra do estudo foi composta por 319 trabalhadores da constru??o civil de ambos os sexos. Para a coleta de dados foram realizadas entrevistas para a obten??o de informa??es sociodemogr?ficas, de ocupa??o profissional, de estilo de vida e uso de fatores de prote??o ? exposi??o solar. Adicionalmente, todos os trabalhadores passaram por um exame bucal e procedimentos para o diagn?stico da queilite act?nica. Os trabalhadores na sua maioria eram do sexo masculino (99,4%), apresentavam cor da pele negra (48,3%) e idade m?dia de 37 anos. A maior parte era procedente de zona urbana (51,7%), casado (36,7%) e apresentavam o n?vel de escolaridade de ensino fundamental incompleto (50,2%). A renda mensal m?dia foi de 1.139,28 reais. A preval?ncia de queilite act?nica entre os participantes do estudo foi de 13,5% (IC 95%: 10,2 ? 17,7). Foram encontradas associa??es entre cor da pele branca (RP=5,44; IC 95%: 3,37-8,80), idade maior ou igual a 37 anos (RP=1,98; IC 95%:1,06-3,69), tempo de trabalho na constru??o civil maior ou igual a 10 anos (RP= 2,26; IC 95%: 1,29 ? 3,27) e a presen?a da les?o. Uma preval?ncia alta de queilite act?nica foi observada nos trabalhadores da constru??o civil, o que indica a necessidade de medidas educacionais e preventivas sobre o risco ocupacional da radia??o solar e de outros fatores de risco para o c?ncer oral nesta popula??o.

Made available in DSpace on 2016-04-04T18:27:37Z (GMT). No. of bitstreams: 1 Camila Ribeiro Coelho.pdf: 365313 bytes, checksum: 3ec8f0be6e61422c6dfb5fb485acdfec (MD5) Previous issue date: 2008-02-13 / Pontif?cia Universidade Cat?lica de Campinas / Diabetes Mellitus is a chronic disease, characterized by a complex treatment. The present study was aimed at analyzing the contingencies to which type 2 diabetic patients would be submitted to concerning disease-related treatment conditions. Participants were 8 chronically ill adults under follow-up treatment at a health center in the city of Campinas Sao Paulo. A semi-structured interview questionnaire, and both the identification and the clinic evaluation forms were used for evaluation. Participants were divided into 2 groups by the test results of glicosilated hemoglobin (criterion that determines diabetes control): Group A (control) and Group B (non control). The results showed that Group A presented high compliance regarding instruction following on glucemia measurement, increased self control behaviors and positive reinforcement contingencies, compared to group B. Regarding insulin administration Group A presented greater discrimination of private events than group B. As to diet control there was a prevalence of self-ruled behaviors and self-controlled behaviors by Group A compared to Group B. On physical activity practice Group A demonstrated discrimination of private events and positive reinforcement. These results may be beneficial in directing future intervention programs that focus on promoting treatment enrollment behaviors. / O diabetes mellitus ? uma doen?a cr?nica, caracterizada por um tratamento complexo. O presente estudo teve como objetivo analisar as conting?ncias a que portadores de diabetes tipo 2 estariam submetidos frente as condi??es impostas pelo tratamento da doen?a. Participaram da pesquisa 8 adultos com o diagn?stico da doen?a e que realizavam acompanhamento m?dico em um centro de sa?de da cidade de Campinas. Para a avalia??o foi utilizada ficha de identifica??o, ficha de avalia??o cl?nica e o roteiro de entrevista semi-estruturada. A partir do resultado do exame de hemoglobina glicada (crit?rio que determina o controle do diabetes), os participantes foram divididos em 2 grupos: Grupo A (com controle) e o Grupo B (sem controle). Os resultados obtidos, com rela??o ? mensura??o da glicemia, mostraram que houve um melhor seguimento das orienta??es passadas pela equipe, comportamentos de autocontrole e conting?ncias de refor?amento positivo, do Grupo A em rela??o ao Grupo B. Na administra??o da insulina, o Grupo A apresentou uma melhor discrimina??o de eventos privados do que o Grupo B. No controle da dieta houve a preval?ncia de comportamentos governados por regras e de comportamentos autocontrolados no Grupo A do que no B. A pr?tica de exerc?cio f?sico revelou a presen?a de refor?o positivo e discrimina??o de eventos privados no Grupo A. Os resultados apresentados podem favorecer o direcionamento de poss?veis programas de interven??o que tenham como foco a promo??o de comportamentos de ades?o ao tratamento.