Orientador: Francisco Jose´[UNESP] Teixeira Neto / Resumo: Girotto, C.H. Avaliação da máscara laríngea como alternativa a sonda endotraqueal para manutenção da anestesia inalatória sob ventilação espontânea em capivaras (Hydrochoerus hydrochaeris). 47 p. Dissertação (Mestrado) – Faculdade de Medicina, Universidade Estadual Paulista, Botucatu, 2018. A intubação orotraqueal roedores é um procedimento de maior dificuldade que em outras espécies. Este estudo comparou o uso máscara laríngea humana (ML) com a sonda endotraqueal (Sonda-ET) para manter a patência da via aérea em capivaras anestesiadas sob ventilação espontânea. Seis capivaras (24-54 kg) foram contidas quimicamente com cetamina (7,2 ± 1,1 mg/kg), midazolam (0,16 ± 0,04 mg/kg) e acepromazina (0,03 ± 0,01 mg/kg) em duas ocasiões (intervalos ≥ 7 dias entre procedimentos). A anestesia foi mantida com isoflurano diluído em oxigênio durante 90-120 minutos sob ventilação espontânea. Durante cada anestesia, a patência da via aérea foi mantida aleatoriamente com a Sonda-ET ou ML. Tomografia computadorizada (TC) da faringe/laringe foi realizada em 3/6 animais com a ML e 2/6 animais com a Sonda-ET. A ANOVA de duas vias para medidas repetidas, teste t pareado ou de Wilcoxon foram utilizados para análise estatística (P < 0,05). A concentração de isoflurano expirado (ETiso), freqüência cardíaca (FC), pressão arterial média invasiva (PAM), pH arterial, pressão parcial de dióxido de carbono arterial (PaCO2) e pressão parcial de oxigênio arterial (PaO2) não diferiram entre os tratamentos. Os ... (Resumo completo, clicar acesso eletrônico abaixo) / Abstract: Abstract Girotto, C.H. Evaluation of a laryngeal mask as an alternative to orotracheal intubation for maintenance of inhalant anesthesia under spontaneous ventilation in capybaras (Hydrochoerus hydrochaeris). 47 p. Dissertation (MSc) – School of Medicine, São Paulo State University, Botucatu, 2018. Orotracheal intubation carries greater difficulty in rodents than in most domestic species. This study compared the human laryngeal mask (LMA) with an endotracheal tube (ETtube) for maintaining airway patency in anesthetized capybaras (Hydrochoerus hydrochaeris). Six capybaras (24–54 kg) were remote darted with ketamine (7.2 ± 1.1 mg/kg), midazolam (0.16 ± 0.04 mg/kg) and acepromazine (0.03 ± 0.01 mg/kg) in two occasions (≥ seven-day intervals). Anesthesia was maintained with isoflurane in oxygen for 90–120 min under spontaneous ventilation. During each anesthetic, the airway was randomly maintained with an ETtube or LMA. Computed tomography of the pharynx/larynx was performed in 3/6 animals and 2/6 animals with the LMA and ETtube, respectively. Data was analyzed with a two-way ANOVA for repeated measures, paired t-test or Wilcoxon´s signed-rank test. End-tidal isoflurane (ETiso), heart rate (HR), invasive mean arterial pressure (MAP), arterial pH, arterial carbon dioxide partial pressure (PaCO2), and arterial oxygen partial pressure (PaO2) did not differ between treatments. Median (lower–upper range) of ETiso values were 0.6 (0.5–1.5)% and 0.6 (0.4-0.9)% with the ETtube and LMA, r... (Complete abstract click electronic access below) / Mestre

Made available in DSpace on 2014-06-11T19:30:29Z (GMT). No. of bitstreams: 0 Previous issue date: 2001Bitstream added on 2014-06-13T18:40:40Z : No. of bitstreams: 1 abud_tmv_dr_botfm.pdf: 265309 bytes, checksum: e3b637e472f866c08307b35491fa04cb (MD5) / Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) / Justificativa: a hiperinsuflação do balonete do tubo traqueal, causada pela rápida difusão do óxido nitroso (N2O), pode determinar lesões traqueais. Objetivos: comparar as pressões de balonetes de tubos traqueais, contendo ou não válvula reguladora de pressão, durante anestesia com N2O e estudar as eventuais lesões da mucosa do segmento traqueal em contato com o balonete do tubo traqueal. Método: dezesseis cães foram submetidos à anestesia venosa com pentobarbital sódico e anestesia inalatória com N2O (1,5 L.min-1) e O2 (1,0 L.min -1). Os cães foram distribuídos aleatoriamente em dois grupos de acordo com o tubo traqueal utilizado: G1 (n=8) tubo traqueal convencional com balonete de baixa pressão (Portex Blue-Line, Inglaterra); G2 (n=8) tubo traqueal dotado de válvula reguladora de pressão de Lanz (Mallincrodt, EUA). Em ambos os grupos, a insuflação do balonete foi feita com ar até a pressão de 30 cm H2O. A medida da pressão do balonete foi realizada através de manômetro (Mallincrodt, EUA), antes e após 60, 120 e 180 minutos do início da... / Background: High endotracheal tube intracuff pressure caused by fast diffusion of nitrous oxide (N2O) may cause mucosal tracheal lesions. Objectives: We have studied the effects of endotracheal tubes intracuff pressures with or without pressure regulating valve on tracheal mucosa during anesthesia with N2O. Methods: Sixteen dogs were submitted to intravenous anesthesia with pentobarbital and inhalational anesthesia with N2O (1.5 L.min-¹) and O2 (1.0 L.min-¹). The dogs were randomly allocated to two groups according to the endotracheal tube: G1 (n=8) conventional endotracheal tube with low-pressure cuff (Portex Blue-line, England); G2 (n=8) endotracheal tube with pressure regulating valve of Lanz from Mallincrodt (USA). In both groups the cuff insufflation was done with air to adjust cuff pressure to 30 cm H2O. Intracuff pressure was measured using a manometer at zero (control) and 60, 120 and 180 minutes after inhation of the N2O. The animals were sacrificed and biopsy specimens from areas of the trachea in contact with the endotracheal cuff were... (Complete abstract, click electronic address below)

Bakgrund: På intensivvårdsavdelningar finns olika rutiner kring huruvida endotrakealtubens position hos intuberade skall skiftas eller bibehållas i samma mungipa, då sidbyten kan leda till allvarliga komplikationer. Rutinen vid CIVA har varit att byta endotrakealtubens position på alla intuberade patienter en gång per dygn. Varken rutinen med skifte samt bibehållen position har utvärderats. Syftet med studien är att undersöka oralt intuberade patienters munhälsa vid bibehållen position av endotrakealtub under vårdtiden. Metod: Studien är en kvantitativ deskriptiv tvärsnittsstudie. Ett protokoll utformades för att undersöka hur stor andel av patienterna som får tryckskador i munnen med bibehållen tublägesposition. Resultat: Av totalt 85 oralt intuberade patienter utvecklade 10 rodnad och 7 sår medan 68 hade helt intakt slemhinna. Flest nyupptäckta sår uppkom efter 3-4 dagars intubering medan rodnader var jämnt fördelat. Slutsats: Endast ett fåtal patienter utvecklade tryckskador. Rutinen att bibehålla endotrakealtuben i samma position lämpar sig på patientkategorin på CIVA eftersom medelvårdtiden för intuberade är 3,2 dagar och flertalet extuberas under de 3 första dagarna. Klinisk betydelse: Studien ligger till grund för CIVA:s ändrade rutin att bibehålla endotrakealtubspositionen i samma mungipa och skulle på sikt kunna bidra till att minska samhällskostnaderna genom att reducera förekomsten av VAP och därmed patientvårdtiden / Background: Intensive care units have different routines whether the endotracheal tube position should be shifted or maintained in the same corner of the mouth. Repositioning of the tube can lead to serious complications. The routine at CIVA has been to change the endotracheal tube position in all intubated patients once per day. None of the routines have been evaluated. The objective of this study is to examine the oral health of intubated patients with maintained tube position. Method: The study is a quantitative descriptive cross-sectional study. A protocol was designed to examine the proportion of patients receiving pressure sores in the mouth. Results: Of a total of 85 orally intubated patients, 10 developed redness and 7 wounds while 68 had intact mucosa. The majority of the newly discovered sores occurred after 3-4 days of intubation. Conclusion: Only a few patients developed pressure sores. The routine to maintain the endotracheal tube in the same position is suitable for the patient category at CIVA since the average length of stay for intubated is 3.2 days and the majority were extubated during the first 3 days . Clinical significance: This study is the basis for CIVA's changed routine to maintain the endotracheal tube position in the same corner of the mouth and could eventually help to reduce the costs for society by reducing the incidence of VAP and thus patient care period.

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Bakgrund Vid ett prehospitalt hjärtstopp krävs utöver hjärt- och lungräddning med bröstkompressioner och defibrillering med hjärtstartare, även avancerad luftvägshantering för att skapa en fri luftväg vilket ambulanssjuksköterskan ansvarar för. Det finns en mängd olika luftvägshjälpmedel som ambulanssjuksköterskan kan använda sig av. För en del sjuksköterskor inom ambulanssjukvården kan en viss osäkerhet kring användningen av luftvägshjälpmedel finnas då de kan sakna rätt kompetens, utbildning eller ej fått tillräcklig träning i användandet för att utföra det på ett patientsäkert sätt.   Syfte Syftet med denna studie var att jämföra prehospitala luftvägshjälpmedel vid hjärtstopp utanför sjukhus i förhållande till överlevnad.   Metod Studien är en litteraturöversikt med kvantitativ ansats. Studien genomfördes genom en systematisk sökning av vetenskapliga artiklar vilka har jämfört olika luftvägshjälpmedel vid prehospitala hjärtstopp. Databaser som PubMed och CINAHL har främst använts. De utvalda artiklarna har kvalitetsgranskat.   Resultat Två huvudfynd framkom där mask- och blåsa var korrelerad till högre prevalens av överlevnad och där endotracheal intubering var korrelerad till högre prevalens att uppnå återkomst av spontan cirkulation.   Slutsats Av de inkluderade artiklarna visar resultatet på att mask- och blåsa är bästa alternativet för överlevnad och att endotracheal intubering är bästa alternativet för att uppnå återkomst av spontan cirkulation under ett prehospitalt hjärtstopp. Dock bör slutsatsen tas med försiktighet då resultaten kan skilja sig och bero på en mängd olika faktorer som skiljer sig åt i de olika studierna. / Background In addition to cardiac and pulmonary rescue with chest compressions and defibrillation with defibrillator, pre-hospital cardiac arrest also requires advanced airway management to create a clear airway for which the ambulance nurse is responsible. There are a variety of respiratory aids that the ambulance nurse can use. For some nurses in ambulance care, there may be some uncertainty about the use of respiratory aids as they may lack the right skills, education or have not received sufficient training in the use of it to perform it in a patient-safe manner.   Aim The purpose of this study was to compare prehospital airway aids in cardiac arrest outside of hospital in relation to survival.   Method The study is a literature review with a quantitative approach. The study was conducted through a systematic search of scientific articles comparing different respiratory aids at prehospital cardiac arrest. Databases such as PubMed and CINAHL have mainly been used. The selected articles have been quality checked.   Results Two main findings emerged where bag valve mask was correlated to higher prevalence to survival and where endotracheal intubation was correlated to higher prevalence to achieve return of spontaneous circulation.    Conclusion Of the included articles, the results indicate that bag valve mask is the best option for survival and that endotracheal intubation is the best option for achieving return of spontaneous circulation during a prehospital cardiac arrest. However, the conclusion should be taken with caution as the results may differ and depend on a variety of factors that differ in the different studies.

Este estudo trata-se de uma revisão sistemática da literatura e tem como referencial teórico a prática baseada em evidência. Buscou-se identificar e analisar na literatura evidências oriundas de ensaios clínicos controlados e randomizados sobre os cuidados relacionados à aspiração de secreções endotraqueais em pacientes adultos, em estado crítico, intubados e sob ventilação mecânica. Os passos metodológicos desta revisão foram guiados pelas recomendações da Colaboração Cochrane. A busca foi realizada nas bases de dados PUBMED, EMBASE, CENTRAL, CINAHL e LILACS. Das 631 referências encontradas, 17 estudos foram selecionados após a análise dos títulos e resumos. Foi realizada a extração dos dados e análise do risco de viés por dois revisores, para cada estudo selecionado. Os 17 estudos foram publicados no período de 1987 à 2009. Ao todo, foram investigados 2.890 pacientes adultos, intubados e sob ventilação mecânica. Foram encontradas evidências quanto a seis categorias de intervenções relacionadas à aspiração endotraqueal: aspiração endotraqueal baseada em pesquisa x aspiração endotraqueal usual, em um estudo; aspiração endotraqueal de rotina x aspiração endotraqueal minimamente invasiva, em dois estudos; aspiração endotraqueal de sistema aberto x aspiração endotraqueal de sistema fechado, em oito estudos; troca do sistema fechado em 24 horas x 48 horas, em dois estudos; troca diária do sistema fechado x troca não rotineira, em um estudo; e instilação de soro fisiológico x não instilação de soro fisiológico, em três estudos. As intervenções foram realizadas analisando desfechos referentes a alterações hemodinâmicas, alterações dos gases sanguíneos, colonização microbiana e infecção nosocomial, e outros desfechos. Foram encontradas evidências relevantes quanto à prática da aspiração endotraqueal, entretanto, as limitações metodológicas e riscos de viés encontrados nos estudos selecionados reduzem a confiabilidade de tais evidências, demonstrando a necessidade de estudos futuros. Também, foi observada a necessidade da realização de ECCRs que contemplem os demais passos da aspiração endotraqueal e desfechos. / This systematic review of literature used the evidence-based practice as the theoretical framework. This study aimed to identify and analyze in the literature the evidence of randomized controlled trials on care related to the endotracheal secretions suctioning in critically ill adult patients who were intubated and undergoing mechanical ventilation. The methodological steps were guided by the recommendations of the Cochrane Collaboration. The search was conducted in the PUBMED, EMBASE, CENTRAL, CINAHL and LILACS databases. Of the 631 found references, 17 studies were selected after the analysis of titles and abstracts. The data extraction and the analysis of the risk of bias by two reviewers for each selected study were performed. The 17 studies were published in the period from 1987 to 2009. In the total, 2,890 adult patients who were intubated and undergoing mechanical ventilation were investigated. Evidences for six categories of interventions related to endotracheal suction were found: research-based endotracheal suction x usual endotracheal suction, in one study; routine endotracheal suction x minimally invasive endotracheal suction, in two studies; open endotracheal suction system x closed endotracheal suction system, in eight studies; change of closed system in 24 hours x 48 hours, in two studies; daily change of closed system x non-routine change, in one study; and instillation of saline x non-instillation of saline, in three studies. The interventions were performed through the analysis of outcomes related to hemodynamic alterations, blood gas alterations, microbial colonization and nosocomial infection, and other outcomes. Relevant evidences related to the practice of endotracheal suction were found; however, methodological limitations and risks of bias found in selected studies reduce the reliability of such evidences, demonstrating the need for further studies. Also, the need for the realization of ECCRs that address the remaining steps of endotracheal suction and outcomes were observed.

Syfte: Att undersöka huruvida patienterna upplever det postoperativa förloppet avseende smärta i hals, heshet, smärta vid sväljning samt generellt obehag beroende på om endotrakealtub (ETT) eller i-gel supraglottic airway device (SAD) använts i samband med generell anestesi vid elektiv kirurgi. Metod: I denna kvantitativa tvärsnittsstudie samlades informationen in på formulär. Parametrarna skattades av patienterna med hjälp av visuell analog skala (VAS). 60 patienter tillfrågades konsekutivt till studien och 13 föll bort vilket resulterade i 47 patienter som fullföljde studien. Resultat: Gällande graden av smärta i hals, heshet, sväljsvårigheter och allmänt obehag postoperativt så skattade sammanlagt sju deltagare i grupperna med ETT och i-gel ett VAS värde över 3. Patienter som haft ETT upplevde signifikant mer heshet, och sväljsvårigheter än patienter som haft i-gel. Slutsats: Denna studie visar att patienter som får ETT eller i-gel skattar sina besvär avseende smärta i hals, heshet, sväljsvårigheter och allmänt obehag i en låg frekvens. Dessutom påvisas att majoriteten av de som skattar besvär gör detta i de lägre segmenten av VAS skalan. / Aim: To examine how patients perceive the postoperative recovery in regards of pain in the throat, hoarseness, dysphagia, and general discomfort due to the endotracheal tube (ETT) or the i-gel supraglottic airway device (SAD) used in general anaesthesia during elective surgery. Method: This quantitative cross-sectional study gathered information on forms. The parameters were estimated by patients using visual analogue scale (VAS). 60 patients were asked consecutively to the study and 47 patients completed. Results: The level of pain in the throat, hoarseness, dysphagia and general discomfort post-operatively were estimated by a total of seven participants in the group with ETT and i-gel as higher VAS values than 3. Patients with ETT perceived significantly more hoarseness and dysphagia than patients with i-gel. Conclusion: This study shows that patients with ETT or i-gel estimates their complaint regarding pain in the throat, hoarseness, dysphagia and general discomfort in a low frequency. It also demonstrates that the majority of those who estimate these parameters do so in the lower segments of the VAS scale.