Fung Man-yi, Wendy. / Thesis (M.Phil.)--Chinese University of Hong Kong, 2000. / Includes bibliographical references (leaves 84-106). / Text in English; abstracts and appendices in English and Chinese. / Fung Man-yi, Wendy. / Acknowledgments --- p.i / Presentation --- p.iii / Abstract --- p.iv / Table of Contents --- p.viii / List of Tables --- p.x / List of Figures --- p.xi / Chapter CHAPTER ONE --- Introduction --- p.1 / Research Background --- p.1 / Purpose of the Study --- p.5 / Justification of the Study --- p.6 / Hypotheses --- p.6 / Definition of Terms --- p.7 / Assumptions --- p.8 / Delimitations --- p.8 / Limitations --- p.9 / Significance of the Study --- p.9 / Chapter CHAPTER TWO --- Review of Literature --- p.10 / "Engergy Metabolism During Prolonged, Submaximal Exercise" --- p.10 / "Causes of Fatigue During Prolonged, Submaximal Exercise" --- p.16 / Factors Influencing Muscle Glycogen Resynthesis During Recovery --- p.21 / Factors Influencing Rehydration During Recovery --- p.27 / Effect of Muscle Glycogen Replenishment During Recovery on Subsequent Endurance Capacity --- p.30 / Effect of Rehydration During Recovery on Subsequent Endurance Capacity --- p.32 / Effect of Glycemic Index Meals Before Exercise on Exercise Performance --- p.33 / Chapter CHAPTER THREE --- Methodology --- p.37 / Participants --- p.37 / Equipment and Instrumentation --- p.37 / Standardized Experimental Procedures --- p.38 / Collection and Analysis of Blood Samples --- p.42 / Preliminary Measurements --- p.45 / Dietary Analyses and Training Control --- p.50 / Preliminary Testing --- p.51 / Statistical Analysis --- p.54 / Chapter CHAPTER FOUR --- Results --- p.56 / Run Time to Exhaustion --- p.56 / Dietary Analysis --- p.57 / Postprandial Responses of the Test Meals During Screening Session --- p.58 / Postprandial Responses During Recovery --- p.60 / Responses During Exercise and Recovery --- p.62 / Body Mass Changes and Fluid Balance --- p.74 / Changes in Plasma Volume and Urine Volume --- p.75 / Summary of the Results --- p.76 / Chapter CHAPTER FIVE --- Discussion --- p.77 / Recommendations and Applications --- p.83 / References --- p.84 / Appendixes --- p.107

Siu Ming Fai Parco. / Thesis (M.Phil.)--Chinese University of Hong Kong, 2001. / Includes bibliographical references (leaves 101-117). / Text in English; abstracts in English and Chinese. / Siu Ming Fai Parco. / Acknowledgments --- p.i / Abstract --- p.iii / Table of Contents --- p.vii / List of Tables --- p.ix / List of Figures --- p.x / Chapter CHAPTER ONE --- Introduction --- p.1 / Research Background --- p.1 / Purpose of the Study --- p.6 / Hypotheses --- p.6 / Definition of Terms --- p.7 / Assumptions --- p.8 / Delimitations --- p.9 / Limitations --- p.9 / Chapter CHAPTER TWO --- Review of Literature --- p.10 / Importance of Muscle Glycogen Resynthesis During Recovery from Exercise --- p.10 / Factors Affecting Muscle Glycogen Resynthesis --- p.10 / Muscle Glycogen Resynthesis and Subsequent Endurance Capacity --- p.17 / Importance of Rehydration on Recovery from exercise --- p.22 / Factors Affecting Rehydration --- p.22 / Rehydration and Subsequent Endurance Capacity --- p.25 / Glycemic Index Foods and Exercise --- p.26 / Definition of Glycemic Index (GI) --- p.26 / Ingestion of GI Foods Before Exercise --- p.28 / Ingestion of GI Foods During Recovery --- p.33 / Frequency of CHO Ingestion and Exercise --- p.36 / Chapter CHAPTER THREE --- Methodology --- p.39 / Participants --- p.39 / Equipment and Instrumentation --- p.39 / Preliminary Measurements --- p.40 / Dietary Analysis and Training Control --- p.45 / Preliminary Testing --- p.46 / Standardized Experimental Procedure --- p.51 / Collection and Analysis of Blood Sample --- p.57 / Statistical Analysis --- p.61 / Chapter CHAPTER FOUR --- Results --- p.62 / Run Time to Exhaustion --- p.63 / Dietary Analysis --- p.63 / Postprandial Responses of the Prescribed Foods During Screening Test --- p.64 / Postprandial Responses During Recovery of Main Trial --- p.67 / Metabolic and Physiological Responses During Exercise and Recovery --- p.70 / "Body Mass Change, Fluid Balance and Urine Volume" --- p.89 / Changes in Plasma Volume --- p.90 / Summary of the Results --- p.91 / Chapter CHAPTER FIVE --- Discussion --- p.92 / Recommendations and Applications --- p.99 / References --- p.101 / Appendices --- p.118

The present investigation was designed to examine the effects of the positive manipulation of information on self-efficacy and subsequent performance of 180 female subjects. High, moderate, and low self-efficacy subjects were randomly assigned to a treatment condition in a 3 x 4 x 3 (preexisting self-efficacy x efficacy information source x trials) factorial design. Information from the three efficacy sources of performance accomplishments, verbal persuasion, and vicarious experience was manipulated towards success after subjects completed a muscular leg endurance task. The results supported self-efficacy theory with high self-efficacy subjects extending their legs significantly longer than moderate and low self-efficacy subjects. However, subjects did not differentially [sic] respond to the manipulation of the efficacy information. Results are discussed in terms of efficacy as a mediator of performance on an endurance task as well as the lack of differential changes in efficacy based on the source from which that information is derived.

Aortic baroreflex (ABR) control of blood pressure was examined in 7 untrained (UT) and 8 endurance exercise trained (EET) young men. ABR control of blood pressure was determined during a steady state phenylephrine infusion to increase mean arterial pressure 10-15 mmHg, combined with positive neck pressure to counteract the increased carotid sinus transmural pressure, and low levels of lower body negative pressure to counteract the increased central venous pressure. Functioning alone, the ABR was functionally adequate to control blood pressure. However, ABR control of HR was significantly diminished in the EET subjects due solely to the decrease in the ABR sensitivity. The persistent strain from an increased stroke volume resulting from endurance exercise training could be the responsible mechanism.

Submitted by Nara Lays Domingues Viana Oliveira (naradv) on 2015-07-15T12:20:50Z No. of bitstreams: 1 joaoluis.pdf: 570265 bytes, checksum: 551007f1cdfcb2c78b839277563f66bb (MD5) / Made available in DSpace on 2015-07-15T12:20:50Z (GMT). No. of bitstreams: 1 joaoluis.pdf: 570265 bytes, checksum: 551007f1cdfcb2c78b839277563f66bb (MD5) Previous issue date: 2014-08-29 / Nenhuma / O estudo teve como objetivo apresentar uma revisão da literatura na área da suplementação protéica para praticantes de atividades físicas, treinados ou não. Os suplementos alimentares vêm requerendo, já há algum tempo, uma especial atenção, visto que eles estão inseridos em uma vasta recomendação de uso tanto para atletas quanto não atletas. As razões para esse avanço na fabricação e consumo de suplementos são multifatoriais, como exemplo disso, pode-se citar a busca do corpo perfeito, influenciada principalmente pela mídia, e a restrição da alimentação evitando o alto teor energético, mas, principalmente, associada à impossibilidade de seguir uma dieta natural e saudável, seja por falta de tempo, por indisponibilidade de comprar alimentos ou qualquer outro fator que traga dificuldades na manutenção e regularidade desta dieta. A busca foi realizada em bases de dados eletrônicas e lista de referência dos artigos identificados. Os seguintes descritores, nas línguas portuguesa e inglesa, foram utilizados: “exercício”, “resistência”, “força”, “suplemento proteico”, “adultos”, “whey protein”, “creatina”, “BCAAs”. A busca eletrônica inicial resultou em 181 artigos entre whey protein, creatina e aminoácidos de cadeia ramificada (BCAA). Dos 38 artigos encontrados com BCAA, nenhum deles atendeu aos critérios de inclusão adotados nesta revisão, portanto, foram todos excluídos do processo de revisão. O processo de análise dos estudos indica que as duas suplementações estudadas, (whey protein e creatina) realmente são eficazes, no que tange à resistência, à força e ao ganho de massa muscular, principal foco do presente estudo. / The aim of this study is to present a literature review in the area of protein supplementation for practitioners of physical activities, trained or not. Food supplements are requesting, for some time, special attention, since they are embedded in a broad recommendation to use for both, athletes and untrained. The reasons for this increase in the manufacturing and consumption of supplements are multifactorial, as an example, we can mention the pursuit of the perfect body, greatly influenced by the media, and the restriction of supply by avoiding the high energy content, but mainly associated with the impossibility to follow a natural and healthy diet, either for lack of time, unwillingness to buy food or any other factor that brings difficulties in maintaining this diet and regularity. The search was performed in electronic databases and reference lists of identified articles. The following descriptors, in Portuguese and English, were used: "exercise", "strength", "protein supplement", "adults", “whey protein”, “creatine”, “BCAAs”. The initial electronic search yielded 181 articles between proteinuria whey, creatine and branched chain amino acids (BCAA). Of the 38 articles found with BCAA, none of them met the inclusion criteria in this review, so they were all excluded from the review process. The process of analysis of the two studies indicate that supplementation studied (whey protein and creatine) are really effective, in terms of strength, endurance and strength gain, main concern of this study.

O treinamento concorrente (TC) é frequentemente utilizado por praticantes de atividades físicas e atletas com o intuito de desenvolver a força muscular e o condicionamento aeróbio. No entanto, essa estratégia de treinamento pode atenuar os ganhos de força e hipertrofia muscular em longo prazo, efeito este conhecido como fenômeno da interferência. Há indícios na literatura de que a magnitude da interferência pode ser dependente do volume em que o exercício aeróbio é realizado. Assim, o objetivo do presente estudo foi verificar o efeito do exercício aeróbio realizado com diferentes volumes no desempenho agudo de força máxima e de resistência de força dos membros inferiores. Homens fisicamente ativos (n=21) foram submetidos a seis condições experimentais realizadas em ordem aleatória, sendo três sessões de exercício aeróbio com volumes distintos (3km, 5km e 7km) seguidas pelo teste de força dinâmica máxima (1RM) e outras três sessões de exercício aeróbio com os volumes distintos seguidas pelo teste de resistência de força (4 séries de repetições máximas a 80% 1RM). Para o exercício aeróbio foi realizada a corrida contínua em esteira rolante a 90% do limiar anaeróbio (Lan) e os testes de força foram realizados no exercício leg press 45o. Para a comparação dos valores de 1RM, volume total (VT) e número de repetições máximas (NRM) da sessão de treinamento de força (TF) foi realizada uma análise de modelo misto tendo os volumes do exercício aeróbio como fator fixo e sujeitos como fator aleatório. Testes post-hoc com ajustamento de Tukey foram utilizados para comparações múltiplas. O nível de significância adotado foi de 5%. Não foram observadas diferenças nos valores de 1RM entre as condições. O VT e NRM das condições de 5km e 7km foram menores quando comparados com a condição controle. Ao passo que, o VT da condição de 7km foi menor em relação ao VT das condições de 3km e 5km; e o NRM da condição de 7km foi menor em relação ao NRM da condição de 3km. Não foram observadas diferenças no VT e NRM entre as condições de 3km e controle e entre as condições de 3km e 5km. Em conclusão, o desempenho da resistência de força foi prejudicado após a realização do exercício aeróbio e a ocorrência e a magnitude desta interferência dependeram do volume em que o exercício aeróbio foi realizado. Adicionalmente, o desempenho da força dinâmica máxima não foi prejudicado pela realização prévia do exercício aeróbio / Concurrent training (CT) is frequently utilized by physically active individuals and athletes in order to develop muscle strength and aerobic fitness. However, this training strategy may result in attenuation of the gains on strength and muscle hypertrophy in long term. This effect has been referred to as the interference phenomenon. There are indications that the magnitude of this interference may be dependent on the volume that aerobic exercise is performed. Thus, the aim of the present study was to verify the effect of aerobic exercise performed with different volumes on the acute performance of lower limbs maximum strength and strength endurance. Physically active men (n=21) were submitted to six experimental conditions performed in random order, three aerobic exercise sessions with different volumes (3km, 5km and 7km) followed by the maximum dynamic strength (1RM) test and three aerobic exercise sessions with different volumes followed by strength endurance test (4 sets of maximum repetitions at 80% 1RM). The aerobic exercise was a continuous treadmill run at 90% of the anaerobic threshold (AT) and all strength tests were performed in the leg press 45o. A mixed-model analysis with the volumes of aerobic exercise as a fixed factor and subject as a random factor was performed to compare 1RM values, total volume (TV) and maximum number of repetitions (MNR) of the strength training (ST) session. Post-hoc tests with Tukey adjustments were used for multiple comparisons. The significance level adopted was 5%. No differences were observed in 1RM values among conditions. The TV and MNR of the 5km and 7km conditions were lower when compared to the control condition. The TV of the 7km condition was lower than the 3km and 5km conditions; and the MNR of the 7km condition was lower than the 3km condition. No differences were observed in TV and MNR between the 3km and control conditions and between the 3km and 5km conditions. In conclusion, strength endurance performance was impaired when performed after aerobic exercise and the magnitude of this interference depended on the volume of the aerobic exercise. In addition, maximum dynamic strength performance was not affected by prior execution of aerobic exercise

Thesis Title: Enhancing rehabilitation following anterior cruciate ligament reconstruction. Context: Physical training with a neuromuscular focus has been shown to reduce anterior cruciate ligament (ACL) injury. However, ACL injury remains prevalent and often leads to joint instability, which requires surgical reconstruction. Following reconstructive surgery, a minimum of 6 months supervised rehabilitation is recommended with associated with financial cost implications to the National Health Service (NHS), the patient and society. Traditionally rehabilitation is offered in a concurrent format, whereby strength and cardio-vascular endurance exercises are performed in the same session. However, accumulating evidence from healthy populations, suggests that the development of strength might be attenuated by cardio-vascular endurance conditioning performed in close temporal proximity. This thesis comprises an entirely novel investigation of potential attenuation of strength gains in rehabilitating clinical populations that is associated with temporal incompatibility of physiological conditioning stimuli. No study has previously investigated this phenomenon, whether it might compromise the efficacy of treatment or recovery, or its potential influence on objectively-measured and patients’ perception of functional, musculoskeletal and neuromuscular performance capabilities. Objectives: The purpose of this thesis was to assess the effects of reconstruction surgery and 24 weeks of non-concurrent strength and endurance rehabilitation (with 48 week post-operative follow-up) on (a) subjective (IKDC; KOOS; PP [Chapter 4]) and objective measures of function (HOP [Chapter 5]) (primary outcome measures for this thesis), and (b) objective measures of musculoskeletal (ATFD) and neuromuscular performance (PF, EMD, RFD, SMP [Chapter 5]) (secondary outcome measures), in patients with anterior cruciate ligament deficiency. The secondary aim was to evaluate the relationships amongst a subjective outcome of function (IKDC), an objective outcome of function (HOP), and the secondary objective outcomes of musculoskeletal (ATFD) and neuromuscular (PF, RFD, EMD, SMP) performance at pre-surgery and at 24 weeks post-surgery (Chapter 6). Setting: Orthopaedic Hospital NHS Foundation Trust. Design: Prospective random-allocation to group trial involving iso-volume rehabilitative intervention versus contemporary practice, using contralateral limb assessment and clinico-social approbation controls. The design compared the effects of experimental post-surgical rehabilitation comprising non-concurrent strength and endurance conditioning with two conditions of control reflecting contemporary clinical practice (matched versus minimal assessment interaction). Participants: Eighty two patients (69♂, 13♀, age: 35.4 ± 8.6 yr; time from injury to surgery 9.4 ± 6.9 months [mean ± SD]) electing to undergo unilateral ACL reconstructive surgery (semitendinosus and gracilis graft [n = 57]; central third, bone-patella tendon-bone graft [n = 25]); were allocated to groups (2:2:1 purposive sampling ratio, respectively). Nineteen patients were lost to follow-up. Intervention: A standardised traditional concurrent (CON) ACL rehabilitation programme acted as the control versus an experimental non-concurrent (NCON) ACL rehabilitation programme that involved separation of strength and cardio-vascular endurance conditioning. An additional control group (Limited testing CON) matched the CON group rehabilitation applied within contemporary clinical practice. Outcome Measures: Chapter 4: The self-perceived primary outcome measures of function IKDC, KOOS and PP were assessed on five separate occasions (pre-surgery, and at 6, 12, 24 and 48 weeks post-surgery). However, assessment occasions were purposefully reduced to pre-operative and 48 weeks post-operative for the Limited testing CON group. Chapter 5: The primary objective outcome of function was HOP; the secondary outcomes were ATFD, PF, RFD, EMD and SMP associated with the knee extensors and flexors of the injured and non-injured legs. These objective outcomes were assessed on five separate occasions (pre-surgery, and at 6, 12, 24 and 48 weeks post-surgery). However, assessment occasions were purposefully reduced to pre-operative and at 48 weeks post-operative only for the Limited testing CON group. Chapter 6 Self-perceived (IKDC) subjective knee evaluation and the objective outcome of function (HOP), and selected objective outcomes of musculoskeletal and neuromuscular performance including ATFD, PF, RFD, EMD and SMP of the knee extensors and flexors of the injured and non-injured legs where applicable; measured at pre-surgery and at 24 weeks post-surgery were analysed for association, using Pearson product-moment correlation coefficients. A priori alpha levels were set at p<0.05. Results: Chapter 4: Factorial analyses of variance (ANOVAs) with repeated-measures investigating the primary aim showed significant group (NCON; CON) by test occasion (pre-surgery, 6, 12. 24 and 48 weeks post-surgery) interactions for self-perceived outcomes of function IKDC, KOOS and PP confirmed increased clinical effectiveness of NCON conditioning (F(2.0, 82.9)GG = 4.0 p<0.05, F(2.2, 134.7)GG = 5.5 p<0.001, F(1.9, 121.4)GG = 14.6 p<0.001, respectively) and the group mean peak relative difference in improvement for NCON was ~5.9% - 12.7% superior to CON. The greatest interaction effect was found to occur between pre-surgery and the 12 weeks post-operative test occasion for IKDC and KOOS, and between pre-surgery and the 24 week test occasion for PP. Patterns of improvements in self-perceived fitness over time were represented by a relative effect size range of 0.71 to 1.92. Improvement patterns were not significantly different between control groups offering matched or minimised assessor-patient interaction (CON vs. Limited testing CON; pre-surgery vs. 48 weeks post-surgery) indicating that clinical approbation by patients had not contributed to the outcome. Chapter 5: Factorial analyses of variance (ANOVAs) with repeated-measures showed significant group (NCON; CON) by leg (injured/non-injured) by test occasion (pre-surgery, 6, 12, 24 and 48 weeks post-surgery) interactions of the objective measure of function (HOP) together with the secondary outcomes of ATFD, PF, RFD, EMD and SMP. Similar responses were noted for the knee extensors and flexors of the injured and non-injured legs (F(2.1, 248) GG = 4.5 to 6.6; p<0.01) and confirmed increased clinical effectiveness of NCON conditioning (range ~4.7% - 15.3% [10.8%]) better than CON between 12 and 48 weeks. Patterns of improvements in physical fitness capabilities over time were represented by a relative effect size range of 1.92 to 2.89. Improvement patterns were not significantly different between control groups offering matched or minimised assessor-patient interaction (CON vs. Limited testing CON; pre-surgery versus 48 weeks post-surgery) indicating that clinical approbation by patients had not contributed to the outcome. Chapter 6: Two-tailed probabilities were used due to the exploratory nature of this study. A limited number of weak to moderate statistically significant correlations were confirmed (ranging from r = 0.262 – 0.404; p<0.05; n=48 [amalgamated NCON and CON groups] ) between IKDC and most notably, the neuromuscular performance outcome of EMD. Conclusion: Overall, the patterning and extent of changes amongst self-perceived, functional, musculoskeletal and neuromuscular performance scores offer support for the efficacy of using non-concurrent strength and endurance conditioning to enhance post-surgery rehabilitation. The limited robustness of relationships amongst the validated and frequently-used self-perceived outcome of function [IKDC], and objectively-measured outcomes of function and musculoskeletal and neuromuscular performance suggested that each might properly reflect an important but separate aspect of clinical response and should be deployed to detect change.

Introdução: Força, resistência e atividade muscular são uma área importante de pesquisa e avaliação contribuindo para um melhor entendimento de aspectos musculoesqueléticos de mecanismos de dor e lesão. No entanto, a utilização de testes que avaliem a região lombopélvica ainda é controversa, pois apesar de muitos testes clínicos estarem disponíveis na literatura, ainda não estão estabelecidos quais os mais confiáveis na prática clínica. Objetivos: Estabelecer valores de referência, determinar confiabilidade intra e interexaminador e as medidas de erro de um conjunto de testes clínicos que avaliam a região lombopélvica em indivíduos assintomáticos de diferentes gêneros, faixas etárias e níveis de atividade física. Materiais e Métodos: Para os valores de referência, 152 indivíduos (79 homens, 73 mulheres) estratificados por gênero, faixa etária e nível de atividade física realizaram um conjunto de nove testes clínicos: força isométrica máxima de abdutores, extensores, flexores e rotadores laterais de quadril, resistência nas posições de ponte lateral, ponte frontal, flexores e extensores lombares e atividade muscular da região lombopélvica. Para a confiabilidade, 33 indivíduos foram avaliados por dois examinadores em um intervalo de 3 a 7 dias, onde realizaram aleatoriamente o mesmo conjunto de testes. As medidas de confiabilidade foram avaliadas pelo Coeficiente de Correlação Interclasse (CCI2,1) e as medidas de erro definidas pelo Erro Padrão da Medida (EPM) e pela Mínima Mudança Detectável (MMD). Resultados: Foram observadas diferenças significativas (p<0.05) nos testes clínicos para as variáveis: gênero, faixa etária e nível de atividade física e estabelecidos valores de referência para cada grupo. Todos os testes apresentaram valores de confiabilidade excelente com CCI (IC 95%) maior que 0.8 para as confiabilidades intra e interexaminador; os valores da MMD foram superiores à média do EPM em todos os testes. Conclusão: Os resultados do presente estudo apontam valores de referência que contribuem com o estabelecimento de referências para auxiliar na tomada de decisões clínicas. Além disso, este conjunto de 10 testes apresentou confiabilidade intra e interexaminador bem como valores de EPM e MMD, confirmando a possibilidade de seu uso na prática clínica. / Background: The assessment of the lumbopelvic region is useful for many musculoskeletal dysfunctions. Several clinical tests are commonly used to assess this region, however, reference values for clinical assessments and results concerning method, reliability and error measurements of these tests have not been reported. Objectives: To establish reference values and to determine intra and interrater reliability, standard error of measurement (SEM) and minimum detectable change (MDC) of a set of clinical tests used for assessing the lumbopelvic region in asymptomatic volunteers of different gender, age groups and physical activity levels. Methods: For reference values, 152 subjects (79 men, 73 women) divided by gender, age group and physical activity levels, performed nine clinical tests: Maximum voluntary isometric strength of hip abductors, extensors, flexors and lateral rotators, transversus abdominis(TrA) muscle activity (using a Pressure Biofeedback Unit), prone and side bridges, trunk flexor and extensor endurance tests. To measure reliability, 33 individuals performed the same set of tests, in random order within a week period. Intrarater and interrater analysis were assessed using the Intraclass Correlation Coefficient (ICC) and the error measurements were defined by using the SEM and the MDC. Results: Reference values were established for each group and our results showed significant (p<0.05) differences concerning gender, age group and physical activity levels in clinical tests. In general, strength differences were related to gender and physical activity levels and endurance results could be related to interactions between gender, age group and physical activity levels. All tests presented good reliability indices with an ICC (95%CI) higher than 0.8 for the intrarater and interrater reliability; MDC values were greater than mean of SEM in all tests, confirming its usage for clinical practice assessments. Conclusion: Reference values are necessary to help clinicians in the evaluation of subjects and these results can contribute for clinical practice in providing clinical training targets. Also, this set of tests presented good intra and interrater reliability measures of strength, endurance and TrA muscle activity test as well as SEM and MDC values, confirming its use for assessing the lumbopelvic region.

Foi desenvolvido um diafragma de elevada vida útil e biocompatibilidade a ser utilizado em um dispositivo de assistência ventricular esquerda(DAV) eletromecânico de dimensões reduzidas e totalmente implantável. Foi realizado teste de resistência do diafragma de poliuretana com superfície texturizada. O teste avaliou sua resistência para experimentos In Vivo de até quinze dias com o DAV implantado em bezerro. Uma superfície de endotélio natural tem excelente tromboresistência. A quantidade e as características da neointima formada em um DAV são determinadas pela superfície do material, hemodinâmica e condições físico-patológicas. O implante de patch na aorta abdominal de porco isola as variáveis que normalmente estão presentes durante a utilização do DAV e que interferem na hemocompatibilidade do material. A avaliação das características do material foi obtida com o seu implante na parede da aorta descendente em contato com o fluxo sanguíneo. Diferentes tipos de superfície de contato foram avaliadas em sete experimentos In Vivo. Este estudo está voltado para as reações de interface sangue / material. Um estudo histológico foi realizado ao final de cada experimento para analisar as interações entre o sangue e o material, quantificando e qualificando a intima neo formada sobre a superfície de contato, calcificação e deposições de elementos constituintes do sangue / It has been developed a high lifetime and biocompatible diaphragm to be used in a Left Ventricle Assist Device (LVAD) that is a reduced dimension totally implantable electromechanical device. It has been performed an endurance test on a textured diaphragm made of polyurethane. This test has evaluated the diaphragm resistance to be used in In Vivo tests with the LVAD implanted for fifteen days in calves. A natural endothelial cell surface has excellent thromboresistant characteristics. The quantity and the characteristics of the neointima formed into LVAD are determined by the material surface, hemodynamics of the blood through the device, and the physico-pathological conditions. The patch implantation into the abdominal aorta of pigs has isolated some normal variables that usually are present during LVAD utilization and that may interfere on the material biocompatibility. The evaluation of the material’s characteristics has been enhanced through its implantation at the descending aorta wall in contact with blood flow. Different kinds of contact surfaces of specific polyurethane are tested in seven In Vivo experiments. This study is totally focused in the reaction of the blood-material interface. A histogical study is performed in the end of every animal experiment to analyze the interactions between blood and biomaterial. It’s emphasized the quantification and qualification of the neointima over the blood contact surface, calcification, and blood depositions

O objetivo da presente dissertação foi avaliar e comparar as possíveis diferenças nas adaptações cardiovasculares e funcionais ao treinamento concorrente com e sem a execução de séries com repetições até a falha concêntrica em homens idosos. Trinta e dois homens idosos saudáveis (67,4 ± 4,1) foram alocados randomicamente em três grupos diferentes de treinamento concorrente: Treinamento de força utilizando repetições máximas (GRM, n = 12), Treinamento de força com repetições submáximas (GRNM, n = 11) e Treinamento de força com repetições submáximas com volume equalizado ao realizado pelo GRM (GRNMV, n = 9). Os participantes treinavam duas vezes por semana, durante doze semanas, executando o treinamento aeróbico imediatamente após o treinamento de força. Antes e após a intervenção foi avaliado o Vo2pico através de ergoespirometria, o desempenho funcional utilizando os testes timed up and go (TUG), sentar e levantar 5 vezes (SeL) e preensão manual (PM). Coletou-se amostras de sangue para análise da glicemia, colesterol total, HDL, LDL e triglicerídeos. A pressão arterial sistólica (PAS) e pressão arterial diastólica (PAD) foram mensuradas através de método auscultatório, o desempenho de saltos através do salto agachado (SJ) e salto com contra movimento (CMJ) e a composição corporal avaliada a partir de antropometria. Após a intervenção, foi observado um efeito tempo significativo (P<0,05) no Vo2pico, sem diferenças entre os grupos. No desempenho funcional não foram observadas mudanças em nenhum dos testes. A análise sanguínea demonstrou um efeito tempo significativo (p<0,01) no HDL, sem diferenças entre os grupos, enquanto não houve variações para glicemia, LDL e triglicerídeos. Na altura dos saltos, foi verificado um efeito tempo significativo (p<0,01) no SJ e uma tendência a incremento (p<0,056) no CMJ, sem diferenças entre os protocolos de treinamento. A composição corporal foi alterada pelo treinamento, com efeito significativo na massa de gordura relativa (p<0,001), na massa livre de gordura relativa (p<0,001) e no somatório de dobras cutâneas (p<0,001), sem diferenças entre os grupos. Desta forma, foi observado que todos os protocolos de treinamento foram eficazes para promover mudanças na capacidade aeróbica, no perfil lipídico, no desempenho de saltos e na composição corporal, porém, o GRNM foi mais eficiente, pois promoveu tais adaptações com um volume de treino menor. / The aim of this study was to evaluate and compare the possible differences in cardiovascular and functional adaptations to concurrent training with and without the execution of series with repetitions until concentric failure in elderly men. Thirty-two healthy elderly men (67,4 ± 4,1) were randomly assigned to three different groups of concurrent training: strength training using maximal repetitions (GRM, n = 12), Strength training with submaximal repetitions (GRNM, n = 11), and strength training with submaximal repetitions with volume equalized to that performed by GRM (GRNMV, n = 9). Participants trained twice a week for twelve weeks, performing aerobic training immediately after strength training. Before and after the intervention, VO2peak was evaluated using a metabolic cart, functional performance using the timed up and go (TUG), sit and up 5 times (SUp) and handgrip strength (HS) tests. Blood samples were collected for analysis of glycemia, total cholesterol, HDL, LDL, and triglycerides. The systolic blood pressure (SBP) and diastolic blood pressure (DBP) were measured using the auscultatory method, the jump performance determined by squat jump (SJ) and counter-movement jump (CMJ). Body composition are evaluated through anthropometry. After the intervention, a significant time effect (P <0.05) was observed on VO2peak, with no differences between groups. In functional performance, no changes were observed in any of the tests. Blood analysis showed a significant increase (p <0.01) in HDL, with no differences between groups, whereas there were no changes for glycemia, LDL and triglycerides. In the jump performance, a significant time effect (p <0.01) was observed in the SJ and a trend toward significant increase (p <0.057) in the CMJ, without differences between the training protocols. Body composition was changed by training, with a significant time effect on the relative fat mass (p <0.001), relative fat free mass (p <0.001), and on the sum of skinfolds (p <0.001), with no differences between groups. In this way, it was observed that all training protocols were effective to promote changes in aerobic capacity, lipid profile, jumping performance and body composition, but the GRNM was more efficient, as it induced such adaptations with a lower training volume.