Cheung Ho Yan. / Thesis (M.Phil.)--Chinese University of Hong Kong, 2005. / Includes bibliographical references (leaves 164-175). / Abstracts in English and Chinese. / Abstract --- p.i / Acknowledgements --- p.vi / Publications based on the work in this thesis --- p.vii / Table of content --- p.viii / Abbreviations --- p.xii / Chapter CHAPTER 1 --- INTRODUCTION --- p.1 / Chapter 1.1 --- Traditional Chinese Medicine --- p.1 / Chapter 1.1.1 --- Danshen --- p.2 / Chapter 1.1.2 --- Chemical constituents --- p.5 / Chapter 1.1.3 --- Pharmacological effects --- p.7 / Chapter 1.1.3.1 --- On blood vessels --- p.7 / Chapter 1.1.3.2 --- On blood pressure --- p.8 / Chapter 1.1.3.3 --- On heart --- p.8 / Chapter 1.1.3.4 --- On myocardial ischaemia and reperfusion --- p.9 / Chapter 1.1.3.5 --- On platelet activity --- p.10 / Chapter 1.1.3.6 --- Other actions --- p.11 / Chapter 1.1.4 --- Clinical studies --- p.12 / Chapter 1.2 --- The Vascular System --- p.13 / Chapter 1.2.1 --- The circulation network --- p.13 / Chapter 1.2.2 --- Physiology of blood vessels --- p.13 / Chapter 1.2.3 --- Control of vascular lone --- p.14 / Chapter 1.3 --- Mechanisms of Vasodilatation --- p.16 / Chapter 1.3.1 --- Endothelium derived relaxant factors (EDRFs) --- p.16 / Chapter 1.3.1.1 --- Nitric oxide (NO) --- p.16 / Chapter 1.3.1.2 --- Prostacyclin (PGI：) --- p.17 / Chapter 1.3.1.3 --- Endotheliun-derived hyperpolarization factors (EDHFs) --- p.18 / Chapter 1.3.1.3.1 --- Epoxyeicosatrienoic acids (EETs) --- p.19 / Chapter 1.3.1.3.2 --- Potassium ion (IC) --- p.20 / Chapter 1.3.1.3.3 --- Gap junction --- p.20 / Chapter 1.3.2 --- Signal transduction pathways --- p.21 / Chapter 1.3.2.1 --- Guanylyl cyclase-cGMP pathway --- p.21 / Chapter 1.3.2.2 --- Adenylyl cyclase-cAMP pathway --- p.22 / Chapter 1.3.3 --- Ion channels in vascular smooth muscle cell --- p.24 / Chapter 1.3.3.1 --- Potassium channels (K+ channels) --- p.24 / Chapter 1.3.3.2 --- Calcium channels (Ca2+ channels) --- p.24 / Chapter 1.3.3.3 --- Chloride channel (Cl channel) --- p.25 / Chapter 1.3.4 --- Receptor-operated mechanisms --- p.27 / Chapter 1.3.4.1 --- Muscarinic receptors --- p.27 / Chapter 1.3.4.2 --- Adrenoceptors --- p.27 / Chapter 1.3.4.3 --- Histamine receptors --- p.28 / Chapter 1.3.4.4 --- CGRP receptors --- p.29 / Chapter 1.3.4.5 --- Tachykinin receptors --- p.30 / Chapter 1.4 --- Aims of the studies --- p.31 / Chapter CHAPTER 2 --- MATERIALS AND METHODS --- p.32 / Chapter 2.1 --- Extraction of Water and Lipid-solubie Fractions from Danshen --- p.32 / Chapter 2.1.1 --- Preparation of water-soluble and lipid-soluble fractions --- p.33 / Chapter 2.2 --- Experiments on Rat Knee Joint --- p.35 / Chapter 2.2.1 --- Animals --- p.35 / Chapter 2.2.2 --- Materials --- p.35 / Chapter 2.2.3 --- Preparatory protocols --- p.37 / Chapter 2.2.3.1 --- Anaesthesia of animals --- p.37 / Chapter 2.2.3.2 --- Cannulation of trachea --- p.37 / Chapter 2.2.3.3 --- Cannulation of carotid artery --- p.38 / Chapter 2.2.3.4 --- Blood pressure measurement --- p.38 / Chapter 2.2.4 --- Measurement of knee joint blood flow --- p.39 / Chapter 2.2.4.1 --- Preparation for measurement of knee joint blood flow --- p.41 / Chapter 2.2.5 --- Experimental protocols --- p.41 / Chapter 2.2.5.1 --- Danshen on knee joint blood flow --- p.41 / Chapter 2.2.5.2 --- Antagonists on Danshen --- p.41 / Chapter 2.2.5.3 --- Positive controls --- p.43 / Chapter 2.2.6 --- Image analysis --- p.44 / Chapter 2.2.7 --- Data analysis --- p.44 / Chapter 2.3 --- Experiments on Rat Femoral Artery --- p.45 / Chapter 2.3.1 --- Animals --- p.45 / Chapter 2.3.2 --- Materials --- p.45 / Chapter 2.3.2.1 --- Chemicals --- p.45 / Chapter 2.3.2.2 --- Physiological salt solution --- p.48 / Chapter 2.3.3 --- Preparatory protocols --- p.48 / Chapter 2.3.3.1 --- Small vessel myograph --- p.48 / Chapter 2.3.3.2 --- Isolation and mounting of tissue --- p.49 / Chapter 2.3.4 --- Experimental protocols --- p.50 / Chapter 2.3.4.1 --- Studies on the vasodilator response to Danshen --- p.50 / Chapter 2.3.4.2 --- Studies of antagonists on Danshen --- p.50 / Chapter 2.3.4.2.1 --- Endothelium-dependent mechanisms --- p.51 / Chapter 2.3.4.2.2 --- Endothelium-independent mechanisms --- p.54 / Chapter 2.3.4.2.3 --- K+ channel blockers --- p.54 / Chapter 2.3.4.2.4 --- Positive controls --- p.55 / Chapter 2.3.4.3 --- Danshen on Ca2+-induced contraction --- p.56 / Chapter 2.3.5 --- Data analysis --- p.57 / Chapter CHAPTER 3 --- RESULTS --- p.58 / Chapter 3.1 --- Danshen on Rat Knee Joint Blood Flow --- p.58 / Chapter 3.1.1 --- Topical administration of Danshen --- p.58 / Chapter 3.1.2 --- Antagonists on Danshen --- p.59 / Chapter 3.1.2.1 --- Muscarinic receptor antagonist --- p.59 / Chapter 3.1.2.2 --- β-adrenoceptor antagonist --- p.60 / Chapter 3.1.2.3 --- Histamine receptor antagonists --- p.60 / Chapter 3.1.2.4 --- Nitric oxide synthase inhibitor --- p.61 / Chapter 3.1.2.5 --- Cyclo-oxygenase inhibitors --- p.62 / Chapter 3.1.2.6 --- CGRPi receptor antagonist --- p.62 / Chapter 3.1.2.7 --- NK1 receptor antagonist --- p.63 / Chapter 3.1.2.8 --- Potassium channel inhibitor --- p.64 / Chapter 3.1.2.9 --- "Combination of cyclo-oxygenase inhibitor, nitric oxide synthase inhibitor and CGRP1 receptor antagonist" --- p.64 / Chapter 3.1.3 --- Antagonists on water-soluble fraction of Danshen --- p.91 / Chapter 3.1.3.1 --- Nitric oxide synthase inhibitor --- p.91 / Chapter 3.1.3.2 --- Cyclo-oxygenase inhibitors --- p.91 / Chapter 3.1.3.3 --- CGRP1 receptor antagonist --- p.92 / Chapter 3.1.3.4 --- NK1 receptor antagonist --- p.92 / Chapter 3.1.3.5 --- Potassium channel inhibitor --- p.92 / Chapter 3.2 --- Danshen on Rat Femoral Artery --- p.99 / Chapter 3.2.1 --- Danshen on precontracted arterial ring --- p.99 / Chapter 3.2.2 --- Endothelium-dependent mechanisms --- p.106 / Chapter 3.2.3 --- Endothelium-independent mechanisms --- p.114 / Chapter 3.2.4 --- K+ channel blockers --- p.119 / Chapter 3.2.4.1 --- Effect on Danshen --- p.119 / Chapter 3.2.4.2 --- Effect on water-soluble and lipid-soluble fractions of Danshen --- p.121 / Chapter 3.2.4.3 --- Effect on Danshensu --- p.122 / Chapter 3.2.5 --- Danshen on Ca2+-induced contractions --- p.133 / Chapter CHAPTER 4 --- DISCUSSION --- p.138 / Chapter 4.1 --- In Vivo Studies of Danshen on Rat Knee Joint Blood Flow --- p.139 / Chapter 4.2 --- In Vitro Studies of Danshen on Isolated Rat Femoral Artery --- p.148 / Chapter 4.2.1 --- Comparisons of the use of different precontractors --- p.148 / Chapter 4.2.2 --- Investigations on endothelium-dependent mechanisms --- p.151 / Chapter 4.2.3 --- Investigations on endothelium-independent mechanisms --- p.152 / Chapter 4.2.4 --- Effects of K+ channel blockers --- p.154 / Chapter 4.2.5 --- Inhibition of Ca2+ influx in vascular smooth muscle --- p.157 / Chapter 4.3 --- Comparisons of Results from In Vivo and In Vitro Studies --- p.159 / Chapter 4.4 --- Future Studies --- p.161 / Chapter 4.5 --- Conclusion --- p.162 / REFERENCES --- p.164

INTRODUÇÃO: O tratamento do câncer de mama está associado à morbidade do membro superior, com complicações que têm um impacto significante na qualidade de vida das pacientes. O OBJETIVO deste trabalho foi traçar um protocolo de tratamento fisioterapêutico para prevenir as morbidades após cirurgia de câncer de mama. CASUÍSTICA E MÉTODOS: Este estudo avaliou 132 mulheres com a intervenção da fisioterapia em dois momentos: no primeiro pós-operatório (PO) e entre o 10º - 15º dia do PO. Reavaliações foram feitas nos meses 1, 2, 3, 4, 5, 6 e após um ano do PO. RESULTADOS: O grupo de intervenção precoce mostrou uma recuperação mais rápida da amplitude de movimentos e apresentou menor morbidade em relação ao grupo tardio. CONCLUSÃO: O protocolo fisioterapêutico preconizado, tanto precoce quanto tardio, é eficaz. A recuperação da função do membro superior e o menor índice de morbidades mostram que a fisioterapia deve sempre ser instituída nas pacientes que se submetem à cirurgia de câncer de mama. / INTRODUCTION: The breast cancer treatment is always linked with the morbidity of the upper limb with complications that will have an enormous impact in the quality of life of the patients submitted to breast cancer treatment. Objective : the objective of this study was to develop a physiotherapy protocol in order to prevent morbidities after breast cancer treatment METHODS: This study evaluated 132 patients submitted to physiotherapy sessions in two different moments: 1 st day post surgery and at the 10-15 th day . Follow-ups were made on months 1, 2, 3, 4, 5, 6 and after a year. RESULTS: The earlier group showed a faster recovery of arm range of motion and had less arm morbidity. CONCLUSÃO: O RESULTS: G1 showed a faster flexion and abduction ROM recovery and had less morbidity as compared to the other group. The arm circumferences in the early intervention group had lower values as compared to the late intervention group. CONCLUSION: The physiotherapy protocol used in the study showed its efficacy. The upper arm ROM was recovered and both groups had less arm morbidity.

The purpose of this study was to determine the reliability of two new alternative portable methods for measuring maximal isometric force measures while performing the standard mid-thigh pull. One method, the bar grip method, required the use of the trunk and upper extremity muscles, while the second method, the pelvic belt method, did not. Both methods demonstrated good test-retest reliability via randomized repeated measures over 24-36 hours. Interestingly, the pelvic belt method generally demonstrated average maximal forces up to 65% higher than the bar method. There was a good relationship between both methods. These new alternative methods could provide strength coaches an option for a more efficient, cost-effective, portable means for the mid-thigh pull test.

Work conditions within the public health care sector are physically and psychosocially demanding. This means that balancing work with recovery is essential for employees in order to avoid ill health and stay healthy. This thesis is based on four studies. Study I investigated the prevalence of upper extremity disorders (UED) in female dental personnel. Results showed that 81% reported UED. Consequently, interventions aimed at reducing these risks were called for. Study II investigated the health-related effects of two work-place interventions, physical exercise (PE) and reduced working hours (RWH). Health-improvements were more consistent in the PE group, suggesting that PE may be an appropriate intervention to reduce health-risks. However, there were no effects on recovery from work or fatigue, which may result from other factors, such as overcommitment (OC), that prolong or sustain stress-related activity. Study III showed that high OC was associated with poorer next-day recovery and increased fatigue. Also, OC was a more important predictor of lack of recovery and fatigue than were psychosocial work characteristics. This highlights the importance of considering perseverative cognitions in relation to recovery from work and fatigue, and has implications for interventions targeting work-related ill health. Study IV related lack of recovery and fatigue to cumulative biological risk, allostatic load (AL), and to individual biomarkers. Women with a profile characterized by fatigue, sleep difficulties and lack of short-term recovery had a 2.9 increased risk of AL. This was not shown in analyses of individual biomarkers. In sum, this thesis shows that recovery from work is an important factor in relation to women’s work-related health. Fatigue and recovery should be considered interrelated but distinct concepts and recovery should be assessed as an early risk factor for stress-related disease with early risk being investigated using AL rather than individual biomarkers.

<p>In this project, a number of different clustering algorithms are described and their workings explained. They are compared to each other by implementing them on number of graphs with a known architecture.</p><p>These clustering algorithm, in the order they are implemented, are as follows: Nearest neighbour hillclimbing, Nearest neighbour big step hillclimbing, Best neighbour hillclimbing, Best neighbour big step hillclimbing, Gem 3D, K-means simple, K-means Gem 3D, One cluster and One cluster per node.</p><p>The graphs are Unconnected, Directed KX, Directed Cycle KX and Directed Cycle.</p><p>The results of these clusterings are compared with each other according to three criteria: Time, Quality and Extremity of nodes distribution. This enables us to find out which algorithm is most suitable for which graph. These artificial graphs are then compared with the reference architecture graph to reach the conclusions.</p>

Disertacijoje nagrinėjama pacientų, dėl didelės energijos bukos traumos patyrusių dauginius kūno sužalojimus, kojų ilgųjų kaulų lūžių gydymo įtaka mirčiai. Ištirtas ir su tarptautiniu standartu palygintas pacientų su dauginiais kūno sužalojimais būklės vertinimas ir gaivinimas ikihospitaliniu laikotarpiu. Įvertintas asmenų, patyrusių dauginius kūno sužalojimus, sužalojimų pobūdis, sunkumas, komplikacijos ir baigtis. Įvertinti dauginių kūno sužalojimų gydymo rezultatai, atsižvelgiant į operacinį ar konservatyvų kojų ilgųjų kaulų lūžių gydymą suvienodintose pagal amžių ir sužalojimo sunkumą pacientų grupėse. Nustatyti veiksniai, turintys ���taką pacientų su dauginiais kūno sužalojimais mirčiai. / Influence of lower extremity long bone fracture treatment of severe polytrauma patients after high energy blunt trauma is evaluated. Pre-hospital initial assessment and management of patients with multiple injuries is estimated and compared with the international standard. The nature, injury severity, complications and the outcome of the patients who suffered multiple injuries are evaluated. The treatment results of multiple injuries taking into account lower extremity long bone fractures operative or conservative treatment in pair matching groups of patients are evaluated. The factors that has impact on mortality of the polytrauma patients are determinated.

Tyrimo objektas: asmenų, patyrusių galvos smegenų infarktą, eisenos kokybė. Tyrimo problema. Pagrindiniai eisenos kokybę įtakojantys veiksniai yra liemens funkcija ir kojų raumenų jėga. Patyrus galvos smegenų infarktą sutrinka gebėjimas eiti, eisena tampa asimetrinė, sumažėja ėjimo greitis ir padidėja energijos sąnaudos. Kompensuojant pažeistą kojų raumenų ir liemens funkciją naudojami neoptimalūs ėjimo modeliai. Darbo tikslas: Nustatyti, kokio tipo pratimai – liemens funkcijos lavinimo ar kojų raumenų stiprinimo - turi didesnį poveikį asmenų, patyrusių galvos smegenų infarktą, kokybiniams ėjimo fazių rodikliams. Uždaviniai: 1) įvertinti liemens funkciją lavinančių pratimų poveikį ligonių ėjimo fazių rodikliams; 2) įvertinti kojų raumenų stiprinimo pratimų poveikį ligonių ėjimo fazių rodikliams; 3) palyginti skirtingų kineziterapijos programų poveikį ligonių ėjimo fazių rodikliams. Tyrimo metodika: Penkiasdešimt tiriamųjų – asmenų, prieš 2 savaites patyrusių galvos smegenų infarktą - buvo suskirstyti į dvi grupes po 25 ligonius. Pirmosios grupės ligoniams didžiausią dėmesį kineziterapijos metu skyrėme liemens funkcijos lavinimui, antrosios grupės ligoniams - ėjime dalyvaujančių kojų raumenų stiprinimui. Eisenos rodiklių pokyčius vertinome Brunel pusiausvyros testu (angl. BBA) ir Wiskonsino eisenos skale (angl. WGS). Rezultatai ir išvados. 1. Liemens funkciją lavinantys pratimai statistiškai reikšmingai pagerino asmenų, patyrusių galvos smegenų infarktą, eisenos kokybę. 2... [toliau žr. visą tekstą] / Research object: gait quality of people who sustain the stroke. Research problem. The main factors of gait quality are a trunk control and a force of lower limbs muscular tissues. The stroke affects the ability to walk, the walking becomes asymmetric, and walking speed is slower consequently it increases the expenditure of energy. Non-optimal walking models are used to compensate touched lower limbs muscles and trunk control. The aim of this paper is to determine what kind of training and strenghening exercises after a stroke for a trunk control and lower limbs muscles have more intense influence for qualitative indexes of gait phases. Objectives: 1. to estimate trunk control training exercises effect on a patient’s gait phases; 2. to estimate strengthening exercises of lower limbs muscular tissues effect on a patient’s gait phases; 3. to compare various physical therapy programs effect on a patient’s gait phases. Research methods: fifty patients who had sustained a stroke two weeks ago were divided into two equal groups. During the physical therapy one patients group granted attention to a trunk control training and another group to lower limbs muscular tissues strengthening by some walking exercises. The factors of changed gait were measured by Brunel balance assessment and Wisconsin gait scale. Conclusions. 1. Trunk control training exercises significantly improve patient’s gait quality. 2. Lower limbs muscles strengthening exercises significantly improve patient’s who... [to full text]

Darbo objektas: Fugl – Meyer skalės apatinės galūnės motorinės funkcijos vertinimo dalis ir jos pritaikomumas lietuvių kalba. Darbo problema: pasaulyje galvos smegenų insultas yra viena iš didžiausių visuomenės sveikatos problemų. Dažniausia šios ligos pasekmė – galūnių judesių valdymo sutrikimai. Apie 72 proc. patyrusiųjų GSI yra stebimi kojų judesių valdymo sutrikimai. Siekiant sumažinti galvos smegenų insulto pasekmes, svarbu tinkamai įvertinti reabilitacijos efektyvumą, apimant visas ligos paveiktas sritis. Lietuvoje patyrusiųjų galvos smegenų insultą reabilitacijos efektyvumo įvertinimui oficialiai naudojami instrumentai, kuriais vertinama kasdienė veikla ir pažintinės funkcijos, tačiau nėra oficialiai naudojamo instrumento, tinkamo motorinės funkcijos pažeidimams įvertinti. Fugl – Meyer skalės apatinės galūnės motorinės funkcijos vertinimo dalis, dėl gerų rezultatų įvertinimo kriterijų, yra plačiai naudojama pasaulyje, tačiau Lietuvoje ji nėra pritaikyta. Darbo tikslas: pateikti lietuviškai parengtą Fugl – Meyer judesių atsigavimo po insulto skalės apatinės galūnės motorinės funkcijos vertinimo dalį ir įvertinti jos tinkamumą pritaikomumui lieuvių kalba. Darbo uždaviniai: 1. Išsiaiškinti Lietuvoje pritaikytus instrumentus, skirtus patyrusiųjų galvos smegenų insultą apatinės galūnės motorinės funkcijos vertinimui ir palyginti su kitų šalių praktika. 2. Išsiaiškinti ir įgyvendinti vertinimo instrumento vertimo į gimtąją kalbą procesą. 3. Įvertinti Fugl – Meyer... [toliau žr. visą tekstą] / Object: the Fugl-Meyer assessment scale the part of the lower extremity motor performance and it validation in lithuanian language. Subject: A stroke is a major public health problem. The most frequent result leading stroke is the disorder of the limb motion control. About 72 percent of stroke patients have lower extremity motor function disorders. According The World Health Organization rehabilitation effectiveness assessment must include all areas affected by the disease. It is important to note that the results of stroke rehabilitation outcome measures should be systematically described and classified in an appropriate way. There are two types of instruments for rehabilitation effectiveness assessment for the patients with stroke in Lithuania. One of them assess daily living activities and the other assess psychological functions. However there are no instrument officially applied for evaluation of the motor disfunctions. According to scientific literature articles, one of the most reliable and valid scale of affected lower extremity true recovery, is Fugl – Meyer Assessment scale the part of the lower extremity motor performance. Aim: to present the Fugl-Meyer assessment scale the part of the lower extremity motor performance and assess it validation in lithuanian language. Goals: 1. To investigate the instruments using for assessment of the lower extremity motor function in patients with stroke in Lithuania and to compare with other countries practices. 2. To... [to full text]

Darbo objektas: Fugl – Meyer skalės viršutinės galūnės motorinės funkcijos vertinimo dalis ir jos pritaikomumas lietuvių kalba. Darbo problema: pasaulyje galvos smegenų insultas yra viena iš didžiausių visuomenės sveikatos problemų. Dažniausia šios ligos pasekmė – galūnių judesių valdymo sutrikimai. Po pusės metų nuo įvykusio galvos smegenų insulto net 65 proc. jį patyrusiųjų išlieka rankos parezė arba plegija. Siekiant sumažinti insulto spasekmes, svarbu tinkamai įvertinti reabilitacijos efektyvumą, apimant visas ligos paveiktas sritis. Lietuvoje patyrusiųjų galvos smegenų insultą reabilitacijos efektyvumo įvertinimui oficialiai naudojami instrumentai, kuriais vertinama kasdienė veikla ir pažintinės funkcijos, tačiau nėra oficialiai naudojamo instrumento, tinkamo motorinės funkcijos pažeidimams įvertinti. Fugl – Meyer skalės viršutinės galūnės motorinės funkcijos vertinimo dalis dėl gerų rezultatų įvertinimo kriterijų yra plačiai naudojama pasaulyje, tačiau Lietuvoje ji nėra pritaikyta. Darbo tikslas: pateikti lietuviškai parengtą Fugl – Meyer judesių atsigavimo po insulto skalės viršutinės galūnės motorinės funkcijos vertinimo dalį ir įvertinti jos tinkamumą pritaikomumui lietuvių kalba. Darbo uždaviniai: 1.Išsiaiškinti Lietuvoje pritaikytus instrumentus, skirtus patyrusiųjų galvos smegenų insultą viršutinės galūnės motorinės funkcijos vertinimui ir palyginti su kitų šalių praktika. 2.Išsiaiškinti ir įgyvendinti vertinimo instrumento vertimo į gimtąją kalbą... [toliau žr. visą tekstą] / Object: the Fugl-Meyer assessment scale the part of the upper extremity motor performance and it validation in lithuanian language. Subject: A stroke is a major public health problem. The most frequent result leading stroke is the disorder of the limb motion control. After a half years after the stroke about 65 percent of the patients still have arm paresis or plegija. According The World Health Organization rehabilitation effectiveness assessment must include all areas affected by the disease. It is important to note that the results of stroke rehabilitation outcome measures should be systematically described and classified in an appropriate way. There are two types of instruments for rehabilitation effectiveness assessment for the patients with stroke in Lithuania. One of them assess daily living activities and the other assess cognitive functions. However there are no instrument officially applied for evaluation of the motor disfunctions. According to scientific literature articles, one of the most reliable and valid scale of affected upper extremity true recovery, is Fugl – Meyer assessment scale the part of the upper extremity motor performance. Aim: to present the Fugl – Meyer assessment scale the part of the upper extremity motor performance and assess it validation in lithuanian language. Goals: 1.To investigate the instruments using for assessment of the upper extremity motor function in patients with stroke in Lithuania and to compare with other... [to full text]

Made available in DSpace on 2016-12-12T17:32:55Z (GMT). No. of bitstreams: 1 RESUMO e ABSTRACT Karoliny dos Santos.pdf: 159269 bytes, checksum: 639ce3b27162f2db0c83966f15bedab0 (MD5) Previous issue date: 2014-07-18 / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior / The airflow limitation is the factor that most influences the interruption of activities of daily living (ADLs) in patients with severe chronic obstructive pulmonary disease (COPD). It is common observed the absence of ventilatory reserve, the reduction in inspiratory reserve volume and dynamic hyperinflation. Objective: to investigate ventilatory response and dynamic hyperinflation (DH) induced by three ADL protocols: Glittre-ADL test (TGlittre); an activity test to move objects on a shelf (TEST); and a modified shelf protocol, which isolates upper limbs activities (TEST-M) in patients with COPD (COPDG) and in healthy subjects (CG). This cross-sectional study included 23 patients with COPD (65 ± 6 years old, FEV1 37.2 ± 15.4% pred); and 14 healthy subjects (64 ± 4 years) matched for sex,age and body mass index. Groups performed TGlittre, TEST and TEST-M; the ventilatory response and inspiratory capacity was measured during each test. Ventilatory baseline values were similar between groups (p>0.05). The ventilatory demand (VE/MVV) increased and the inspiratory capacity reduced significantly during the tests in COPDG. VE/MVV and HD were higher (p<0.05) in TEST compared to TEST-M in patients with COPD (p<0.05). In the control group no difference was found in the variation of inspiratory capacity between the tests (p>0.05) and the ventilatory demand increased during the tests (p< 0.05) in smaller magnitude than in the COPDG. In conclusion, TEST and TGlittre induced similar responses in patients with COPD with higher VE/MVV and HD than in healthy subjects. However, the ventilatory response was lower in the TEST-M, suggesting that squatting down and bending the trunk can trigger significant ventilatory overload in TGlittre. / A limitação ventilatória é o fator que mais influencia na interrupção das atividades de vida diária (AVD) em pacientes com doença pulmonar obstrutiva crônica (DPOC) grave, sendo comuns a ausência de reserva ventilatória, a redução do volume de reserva inspiratório e a hiperinsuflação dinâmica. O objetivo deste estudo foi investigar a resposta ventilatória e hiperinsuflação dinâmica induzidas por três protocolos de AVD: teste AVD-Glittre (TGlittre); teste de atividades movimentando objetos em uma estante (TEST); e um protocolo modificado da estante, enfatizando atividade com os membros superiores (TEST-M) em pacientes com DPOC e indivíduos saudáveis. Tratou-se de um estudo transversal no qual foram avaliados 23 pacientes com DPOC (65 ± 6 anos; VEF1 37,2 ± 15,4%prev) e 14 indivíduos saudáveis (64 ± 4 anos), pareados por sexo, idade e IMC. Os grupos realizaram TGlittre, TEST e TEST-M e a resposta ventilatória e capacidade inspiratória foram avaliadas durante cada teste. As variáveis ventilatórias basais foram similares nos grupos (p>0,05). A demanda ventilatória aumentou e a capacidade inspiratória reduziu significantemente durante os testes no grupo de pacientes com DPOC. A demanda ventilatória e a hiperinsuflação dinâmica foram maiores (p<0,05) no TEST comparados ao TEST-M nos pacientes com DPOC (p<0,05). No grupo controle não houve diferença na variação da capacidade inspiratória entre os testes (p>0,05) e a demanda ventilatória aumentou durante os testes (p<0,05) em menor magnitude que no grupo DPOC. Conclui-se que o TGlittre e o TEST induzem respostas similares em pacientes DPOC, com maior demanda ventilatória e hiperinsuflação dinâmica do que em saudáveis. Entretanto no TEST-M a resposta ventilatória foi atenuada, sugerindo que atividades de agachamento e inclinação do tronco podem desencadear sobrecarga ventilatória relevante no TGlittre.