La commedia dell'arte is a recognized, vibrant theatrical form that emerged in Italy during the Renaissance. However, while great attention has been given to the particulars of the genre (performance techniques, important troupes, leading players), there lacks a study behind the reasoning for its vast international popularity. In this thesis, I explore why this particular genre was able to cross cultural and linguistic boundaries, finding a dedicated and enthusiastic following in most European countries for over 200 years. After analyzing commedia dell'arte's original development in the Italian peninsula, examining the predominating Carnival ideology and the ability of the troupes to establish both regional and national symbols through the creation of specific stock characters, I will concentrate on the international tours and performances. By looking at the adaptive qualities of the troupes, and specifically their ability to play off of Europe's lack of national identity and Northern European's fascination with their exotic southern neighbor, I will discuss the reaction of Northern Europe with the Italian theatre, with a detailed look into the success of the troupes abroad. The popularity of the troupes will also be explored through the unique adaptation, assimilation and adoption of commedia dell'arte techniques and characters into developing national theatres of the other countries. I will conclude with a look of how commedia dell'arte has been and can continue to be effectively used in today's theatre. The examination of what drew both native and foreign audiences to the commedia dell'arte performances opens up possibilities for modern practitioners who wish to capitalize on the ability of the troupes to successfully play to a wide spectrum of people.

No description available.

Asynchronous multiplexing schemes are efficient than synchronous schemes, in a bursty traffic environment of multiple access local area network (LAN), as fixed bandwidth is not allocated among the users and there is no access delay. Fiber- Optic Code-Division Multiple Access (FO-CDMA) is one such asynchronous multiplexing scheme suitable for high speed LAN networks. While FO-CDMA offers potential benefits it also faces challenges in three diverse areas which are 1) coding algorithms and schemes 2) advanced encoding and decoding hardware and 3) network architecture. In this thesis, as a solution to the first challenge, we propose the design and construction of a new family of codes, wavelength/time multiple-pulses-per-row (W/T MPR) codes. These codes have good cardinality, spectral efficiency and minimal cross-correlation values. Performance analysis of the W/T MPR codes is carried out and found to be superior to other codes. In unipolar 1-D Optical Orthogonal Codes (OOCs) proposed by Salehi et al., the ratio of code length/code weight grows rapidly as the number of users is increased for a reasonable weight. Hence, for a given pulse width, the data rate decreases or in other words for a given data rate very narrow pulses have to be used, because of which dispersion effects will be dominant. To overcome the drawbacks of non-linear effects in large spread sequences of 1-D unipolar codes in FO-CDMA networks, several two-dimensional codes have been proposed. Wavelength-time (W/T) encoding of the two-dimensional codes is practical in FO-CDMA networks. W/T codes reported so far can be classified mainly into two types: 1) hybrid sequences, where one type of sequence is crossed with another to improve the cardinality and correlation properties and 2) matrix codes, 1-D sequences converted to 2-D codes or 2-D codes by construc- tion, to reduce the ’time’ spread of the sequences/codes. Prime-hop and eqc/prime W/T hybrid codes have been proposed where one type of sequence is crossed with another to improve the cardinality and correlation properties. Other constructions deal with conversion of 1-D sequences to 2-D codes either by using Chinese remainder theorem or folding GoLomb rulers. W/T single-pulse-per-row (W/T SPR) codes are 2-D codes constructed using algebraic method Addition Modulo Group operation. Motivation for this work: To design a family of 2-D codes which have the design choice of length of one dimension over the other, and also have better cardinality, spectral efficiency and also low cross-correlation values (thereby have low BER) than that of the reported unipolar 2-D codes. In this thesis, we describe the design principles of W/T MPR codes, for in- coherent FO-CDMA networks, which have good cardinality, spectral efficiency and minimal cross-correlation values. Another feature of the W/T MPR codes is that the aspect ratio can be varied by trade off between wavelength and temporal lengths. We lay down the necessary conditions to be satisfied by W/T MPR codes to have minimal correlation values of unity. We analytically prove the correlation results and also verify by simulation (of the codes) using Matlab software tool. We also discuss the physical implementation of the W/T MPR FO-CDMA network with optical encoding and decoding. We show analytically that when distinct 1-D OOCs of a family are used as the row vectors of a W/T MPR code, it will have off-peak autocorrelation equal to ‘1’. An expression for the upper bound on the cardinality of W/T MPR codes is derived. We also show that 1-D OOCs and W/T SPR codes are the limiting cases of W/T MPR codes. Starting with distinct 1-D OOCs, of a family, as row vectors, we propose a greedy algorithm, for the construction of W/T MPR codes and present the repre- sentations of the results. An entire W/T MPR code family, generated using greedy algorithm, is simulated for various number of interfering users. Performance analysis of the W/T MPR codes and their limiting cases is carried out for various parameter variations such as the dimensions of wavelength, time and weight of the code. We evaluate the performance in terms of BER, capacities of the networks, temporal lengths needed (to achieve a given BER). Multiple access interference (MAI) signal can be reduced, by using a bistable optical hard-limiter device in the W/T MPR code receiver, by eliminating those signal levels which exceed a certain preset level. Performance analysis of the W/T MPR codes and their limiting cases is studied for various parameter variations. For given wavelength × time dimensions, we compare various W/T codes, whose cardinalities are known, and show that W/T MPR family of codes have better cardinality and spectral efficiency than the other (reported) W/T codes. As W/T MPR codes are superior to other W/T codes in terms of cardinality, spectral efficiency, low peak cross-correlation values and at the same time have good performance, makes it a suitable coding scheme for incoherent FO-CDMA access networks.

The subject of this thesis is the generation of spatial temporal structures in living cells. Specifically, we studied the Min-system in the bacterium Escherichia coli. It consists of the MinC, the MinD, and the MinE proteins, which play an important role in the correct selection of the cell division site. The Min-proteins oscillate between the two cell poles and thereby prevent division at these locations. In this way, E. coli divides at the center, producing two daughter cells of equal size, providing them with the complete genetic patrimony. Our goal is to perform a quantitative study, both theoretical and experimental, in order to reveal the mechanism underlying the Min-oscillations. Experimentally, we characterize theMin-system, measuring the temporal period of the oscillations as a function of the cell length, the time-averaged protein distributions, and the in vivo Min-protein mobility by means of different fluorescence microscopy techniques. Theoretically, we discuss a deterministic description based on the exchange of Minproteins between the cytoplasm and the cytoplasmic membrane and on the aggregation current induced by the interaction between membrane-bound proteins. Oscillatory solutions appear via a dynamic instability of the homogenous protein distributions. Moreover, we perform stochastic simulations based on a microscopic description, whereby the probability for each event is calculated according to the corresponding probability in the master equation. Starting from this microscopic description, we derive Langevin equations for the fluctuating protein densities which correspond to the deterministic equations in the limit of vanishing noise. Stochastic simulations justify this deterministic model, showing that oscillations are resistant to the perturbations induced by the stochastic reactions and diffusion. Predictions and assumptions of our theoretical model are compatible with our experimental findings. Altogether, these results enable us to propose further experiments in order to quantitatively compare the different models proposed so far and to test our model with even higher precision. They also point to the necessity of performing such an analysis through single cell measurements.

Les structures en béton armé ou en bois se dégradent sous des actions mécaniques et climatiques. Les propriétés physiques et mécaniques de ces matériaux sont liées aux conditions d'exposition et à leurs variations. L’évaluation non destructive de ces propriétés en amont des dégradations est une nécessité pour les maîtres d'ouvrages afin de prédire la durée de vie des structures dans un contexte de gestion durable du patrimoine bâti. La présence d’eau dans les pores du béton est un facteur qui facilite la pénétration des agents agressifs (dioxyde de carbone, chlorures, etc. responsables de l’initiation de pathologies comme la corrosion des aciers). Pour le cas du matériau bois, les causes les plus fréquentes des détériorations sont souvent d’origine biologiques (champignons et insectes). L’humidité est également reconnue comme une des conditions les plus importantes pour le développement de ces attaques. Il est donc nécessaire d’évaluer et de quantifier la variation spatiale de l’humidité dans ces matériaux de construction pour limiter les actions de réparation. Le système radar (Ground Penetrating Radar, « GPR ») est un outil d’auscultation des matériaux totalement non destructif, rapide, compact et sans contact. Cette technique est basée sur la propagation des ondes électromagnétiques. Cette propagation est fortement liée à la permittivité et la conductivité du matériau qui sont très sensibles aux variations de l’humidité. L’objectif de cette thèse est double : d’une part, modéliser l’effet des variations de l’humidité dans un matériau homogène, multi-couches ou avec gradient, et d’autre part, de quantifier expérimentalement l’effet d’un gradient d’humidité sur le béton et celui de l’anisotropie sur le bois. Pour cela, un modèle analytique a été développé en se basant sur la notion des lois de mélange (ajustées sur des mesures expérimentales de la permittivité en prenant en compte l’effet de la dispersion fréquentielle) et sur la propagation d’une onde plane. Une simulation numérique a permis d’apprécier l’effet d’un gradient et d’un milieu anisotropique sur la vitesse de propagation des ondes radar. La phase expérimentale a été effectuée sur un matériau modèle homogène et isotrope comme le sable pour comparer les différentes méthodes de mesure de la vitesse de l’onde directe. Une analyse fréquentielle de l’atténuation a été également étudiée pour évaluer la dispersion de l’atténuation dans un milieu considéré comme homogène. La deuxième partie de l’expérimentation a consisté à suivre par mesures radar le séchage d’une dalle en béton instrumentée par capteurs d’humidité. Enfin, une campagne expérimentale sur des échantillons en bois de deux essences (Pin et Epicéa) soumis à des humidités variables entre 0 et 50% a été menée. La phase de modélisation et de simulation a montré que la dispersion fréquentielle est significative seulement dans le cas d’un béton humide à forte salinité et que l’anisotropie et le gradient ont un effet significatif sur la propagation. La phase expérimentale a montré que dans le cas d’un matériau homogène, la vitesse est indépendante de la distance émetteur-récepteur, et qu’elle est variable dans le cas d’un béton soumis à un gradient d’humidité. Enfin, les essais sur le bois montrent que la partie réelle de sa permittivité est croissante en fonction de l’humidité. Le contraste de permittivité entre direction longitudinale et transversale (tangentielle ou radiale) est négligeable à l’état sec du matériau et commence à être significatif à partir de la saturation des fibres. Cela permet de privilégier la direction longitudinale à la direction transversale pour évaluer l’humidité des structures en bois. / The reinforced concrete or the timber structures are degraded under mechanical and climatic actions. Physical and mechanical properties of these materials are linked to outdoor exposure conditions and their variations. The early non-destructive evaluation of these properties before the initiation of degradations is a need for masters of structures in order to predict the service life of the structures in a context of sustainable management of the built heritage. The presence of water in the pores of the concrete is a factor which facilitates the penetration of aggressive agents (carbon dioxide, chlorides, etc. responsible of the initiation of pathologies such as steel corrosion). In the case of wood material, the most common causes of damage are often of biological origin (fungi and insects). Moisture is also recognized as one of the most important conditions for the development of these attacks. It is therefore necessary to evaluate and quantify the spatial variation of the humidity in the building materials to limit repair actions. The GPR system (Ground Penetrating Radar) is an auscultation tool of materials which is completely non-destructive, fast, compact, and contactless. This technique is based on the propagation of electromagnetic waves. This propagation is strongly linked to the permittivity and the conductivity of the material that are highly sensitive to changes in humidity. The objective of this thesis is twofold: first, modelling the effect of moisture variation in a homogeneous material, multi-layers or with gradient, and secondly, to experimentally quantify the effect of a moisture gradient on the concrete and the effect of the anisotropy (case of wood material). An analytical model has been developed based on the concept of mixing laws (Fitted on experimental measurements of the permittivity by taking into account the effect of the frequency dispersion) and the propagation of a plane wave. A numerical simulation was used to assess the effects of a gradient and the effect of an anisotropic medium on the propagation velocity of the radar waves. The experimental phase was performed on a homogeneous and isotropic model material such as sand to compare different measurement methods of the velocity of the direct wave. A frequency analysis of the attenuation was also examined to evaluate the dispersion of the attenuation in a considered homogeneous medium. The second part of the experiment was to monitor, by radar measurements, the drying of a concrete slab instrumented by humidity sensors. Finally, an experimental campaign on samples of two species of wood (Pine and Spruce) with different moisture content between 0 and 50% was conducted. The modelling and simulations phase has shown that the frequency dispersion is significant only in the case of wet concrete with a high salinity content. The anisotropy and the gradient have a significant effect on the spread. The experimental phase showed that in the case of a homogeneous material, the speed is independent of the offset (distance between transmitter and receiver), and it varies in the case of concrete with a moisture gradient. Finally, tests on the timber indicate that the real part of its permittivity increases as a function of moisture. The contrast between longitudinal and transverse direction (tangential or radial) is negligible in the dry state of the material and begins to be very significant from the fiber saturation point. It indicates that the longitudinal direction, instead of the transverse direction, is more convenient to measure the moisture of wood structures.

Introduction: No Fixed-Dose Combination (FDC) formulations currently exist for pediatric tuberculosis (TB) treatment. Earlier work implemented, in the software NONMEM, a rational method for optimizing design and individualization of pediatric anti-TB FDC formulations based on patient body weight, but issues with parameter estimation, dosage strata heterogeneity and representative pharmacokinetics remained. Aim: To further develop the rational model-based methodology aiding the selection of appropriate FDC formulation designs and dosage regimens, in pediatric TB treatment. Materials and Methods: Optimization of the method with respect to the estimation of body weight breakpoints was sought. Heterogeneity of dosage groups with respect to treatment efficiency was sought to be improved. Recently published pediatric pharmacokinetic parameters were implemented and the model translated to MATLAB, where also the performance was evaluated by stochastic estimation and graphical visualization. Results: A logistic function was found better suited as an approximation of breakpoints. None of the estimation methods implemented in NONMEM were more suitable than the originally used FO method. Homogenization of dosage group treatment efficiency could not be solved. MATLAB translation was successful but required stochastic estimations and highlighted high densities of local minima. Representative pharmacokinetics were successfully implemented. Conclusions: NONMEM was found suboptimal for the task due to problems with discontinuities and heterogeneity, but a stepwise method with representative pharmacokinetics were successfully implemented. MATLAB showed more promise in the search for a method also addressing the heterogeneity issue.

In der Bachelorarbeit werden im Rahmen des Studium der Kunstpädagogik an der Universität Leipzig auf Grundlage von Recherche, Quellenstudium, Erfahrungswissen und Synthese einige Aspekte zum Spannungsfeld von BNE und Kunstpädagogik vorgestellt, die einem breiten Publikum einen nachvollziehbaren Zugang sowie ein besseres Verständnis zum Themenkomplex „Bildung für nachhaltige Entwicklung“ ermöglichen sollen. Dazu werden Rahmenbedingungen und entscheidende Dokumente im Kontext der UNESCO-Bestrebungen zur kulturellen Bildung identifiziert sowie Defizite und Reserven im Kontext der weiteren Ausprägung von BNE für den Bereich kunstpädagogischer Praxis abgeleitet.:Vorwort „Aspekte zum Spannungsfeld von Bildung für nachhaltige Entwicklung und Kunstpädagogik (2004–2010)“ 1 Zu Grundlagen der Bildung für nachhaltige Entwicklung 1.1 Bildung für nachhaltige Entwicklung (BNE) 1.1.1 Zu Begrifflichkeiten im Kontext von nachhaltiger Entwicklung 1.2 Bildung für nachhaltige Entwicklung – zu den Ausgangsbedingungen im Juli 2010 1.2.1 BNE und das Leitbild nachhaltiger Entwicklung 2 Bildung für nachhaltige Entwicklung und Kunstpädagogik im Projekt der allgemeinen Bildung 2.1 Gestaltungskompetenz und deren Teilkompetenzen aus Sicht der Bildung für nachhaltige Entwicklung 2.1.1 Zwölf Teilkompetenzen der Gestaltungskompetenz 2.1.2 Sechs Bildungsbereiche der Bildung für nachhaltige Entwicklung 2.2 Kulturelle Bildung, Kunstpädagogik und der homo universale 2.2.1 Zum Spannungsfeld von kultureller Bildung im Kontext von Bildung für nachhaltige Entwicklung 2.3 Zum Spannungsfeld von künstlerischer Bildung im Kontext von Bildung für nachhaltige Entwicklung und Kunstpädagogik 2.3.1 Zur Analyse ausgewählter Dekade-Projekte 3 Ausgewählte Instrumentarien zur Gestaltung und Umsetzung von Bildung für nachhaltige Entwicklung 3.1 Die UNESCO und Bildung für nachhaltige Entwicklung 3.1.1 UN-Dekade „Bildung für nachhaltige Entwicklung 2005–2014“ – ein Feld der Kunstpädagogik? 3.1.2 Zweite UNESCO-Weltkonferenz zur kulturellen Bildung in Seoul (2010) 4 Resümee 4.1 Ausblick Quellen- und Literaturverzeichnis Anhang Abkürzungsverzeichnis Selbständigkeitserklärung

The subject of this thesis is the generation of spatial temporal structures in living cells. Specifically, we studied the Min-system in the bacterium Escherichia coli. It consists of the MinC, the MinD, and the MinE proteins, which play an important role in the correct selection of the cell division site. The Min-proteins oscillate between the two cell poles and thereby prevent division at these locations. In this way, E. coli divides at the center, producing two daughter cells of equal size, providing them with the complete genetic patrimony. Our goal is to perform a quantitative study, both theoretical and experimental, in order to reveal the mechanism underlying the Min-oscillations. Experimentally, we characterize theMin-system, measuring the temporal period of the oscillations as a function of the cell length, the time-averaged protein distributions, and the in vivo Min-protein mobility by means of different fluorescence microscopy techniques. Theoretically, we discuss a deterministic description based on the exchange of Minproteins between the cytoplasm and the cytoplasmic membrane and on the aggregation current induced by the interaction between membrane-bound proteins. Oscillatory solutions appear via a dynamic instability of the homogenous protein distributions. Moreover, we perform stochastic simulations based on a microscopic description, whereby the probability for each event is calculated according to the corresponding probability in the master equation. Starting from this microscopic description, we derive Langevin equations for the fluctuating protein densities which correspond to the deterministic equations in the limit of vanishing noise. Stochastic simulations justify this deterministic model, showing that oscillations are resistant to the perturbations induced by the stochastic reactions and diffusion. Predictions and assumptions of our theoretical model are compatible with our experimental findings. Altogether, these results enable us to propose further experiments in order to quantitatively compare the different models proposed so far and to test our model with even higher precision. They also point to the necessity of performing such an analysis through single cell measurements.

A comercialização de produtos florestais não madeireiros (PFNMs) popularizou-se como atividade promotora do desenvolvimento socioeconômico de comunidades florestais com baixo impacto ambiental. Há evidências, contudo, de que a exploração possa produzir efeitos ecológicos e socioeconômicos negativos, sugerindo que é necessário monitorar tais iniciativas. A comercialização frequentemente ocorre em áreas remotas e em contextos de pobreza, como é o caso de muitas daquelas da Amazônia brasileira. Desta forma, é necessário que o monitoramento restrinja-se a avaliar os efeitos evidenciados como mais comuns em estudos anteriores. Este estudo revisa e sintetiza as evidências científicas dos efeitos da exploração de PFNMs sobre parâmetros ecológicos e socioeconômicos e, a partir daí, indica aqueles mais relevantes ao monitoramento. O estudo também levanta até que ponto o monitoramento é implementado no contexto da Amazônia brasileira e avalia quais os parâmetros importantes e viáveis de monitoramento neste caso específico. Para isso, foram realizadas revisões sistemáticas da literatura e a consulta a profissionais da área através do método Delphi. Os resultados indicam que efeitos ecológicos negativos são frequentes, principalmente quando se coletam folhas ou cascas. Alterações em órgãos ou processos fisiológicos e a taxa de sobrevivência dos espécimes explorados são parâmetros que devem ser monitorados, em particular quando se coletam frutos e partes vegetativas. Para todos os tipos de PFNMs, o tamanho e a estrutura populacional são parâmetros prioritários ao monitoramento. A riqueza de espécies da comunidade explorada merece atenção, principalmente quando se coletam frutos. Para os aspectos socioeconômicos, efeitos positivos foram mais frequentes que negativos. A contribuição da renda monetária obtida com o comércio na renda total, a regularidade de ingresso desta renda e o papel dos PFNMs como recursos de salvaguarda são parâmetros do capital financeiro prioritários ao monitoramento. Para o capital social, o empoderamento feminino, a coesão de grupo e o acesso aos benefícios gerados pela comercialização devem ser monitorados. Na Amazônia brasileira são poucas as iniciativas de implementação do monitoramento da comercialização de PFNMs. Embora este seja considerado importante, existem dificuldades que derivam principalmente da falta de apoio institucional, políticas de incentivo e de recursos financeiros. Os profissionais participantes do Delphi consideram que os parâmetros ecológicos mais importantes a monitorar neste contexto são o tamanho e a estrutura populacional do recurso explorado, o aumento da taxa de mortalidade, a quantidade total de recurso extraída e a técnica de coleta utilizada. Para os parâmetros econômicos, aspectos do mercado, como o preço pago ao coletor, a demanda e a qualidade do produto, bem como a renda monetária obtida pelos indivíduos são os parâmetros considerados mais importantes. Por fim, para os aspectos sociais, os efeitos na cultura, na qualidade de vida e na organização interna da comunidade foram priorizados. Os profissionais indicam que é viável estabelecer o monitoramento dos parâmetros levantados. / Amazon, non-timber forest products, ecological effects, socioeconomic effects, monitoring.

A comercialização de produtos florestais não madeireiros (PFNMs) popularizou-se como atividade promotora do desenvolvimento socioeconômico de comunidades florestais com baixo impacto ambiental. Há evidências, contudo, de que a exploração possa produzir efeitos ecológicos e socioeconômicos negativos, sugerindo que é necessário monitorar tais iniciativas. A comercialização frequentemente ocorre em áreas remotas e em contextos de pobreza, como é o caso de muitas daquelas da Amazônia brasileira. Desta forma, é necessário que o monitoramento restrinja-se a avaliar os efeitos evidenciados como mais comuns em estudos anteriores. Este estudo revisa e sintetiza as evidências científicas dos efeitos da exploração de PFNMs sobre parâmetros ecológicos e socioeconômicos e, a partir daí, indica aqueles mais relevantes ao monitoramento. O estudo também levanta até que ponto o monitoramento é implementado no contexto da Amazônia brasileira e avalia quais os parâmetros importantes e viáveis de monitoramento neste caso específico. Para isso, foram realizadas revisões sistemáticas da literatura e a consulta a profissionais da área através do método Delphi. Os resultados indicam que efeitos ecológicos negativos são frequentes, principalmente quando se coletam folhas ou cascas. Alterações em órgãos ou processos fisiológicos e a taxa de sobrevivência dos espécimes explorados são parâmetros que devem ser monitorados, em particular quando se coletam frutos e partes vegetativas. Para todos os tipos de PFNMs, o tamanho e a estrutura populacional são parâmetros prioritários ao monitoramento. A riqueza de espécies da comunidade explorada merece atenção, principalmente quando se coletam frutos. Para os aspectos socioeconômicos, efeitos positivos foram mais frequentes que negativos. A contribuição da renda monetária obtida com o comércio na renda total, a regularidade de ingresso desta renda e o papel dos PFNMs como recursos de salvaguarda são parâmetros do capital financeiro prioritários ao monitoramento. Para o capital social, o empoderamento feminino, a coesão de grupo e o acesso aos benefícios gerados pela comercialização devem ser monitorados. Na Amazônia brasileira são poucas as iniciativas de implementação do monitoramento da comercialização de PFNMs. Embora este seja considerado importante, existem dificuldades que derivam principalmente da falta de apoio institucional, políticas de incentivo e de recursos financeiros. Os profissionais participantes do Delphi consideram que os parâmetros ecológicos mais importantes a monitorar neste contexto são o tamanho e a estrutura populacional do recurso explorado, o aumento da taxa de mortalidade, a quantidade total de recurso extraída e a técnica de coleta utilizada. Para os parâmetros econômicos, aspectos do mercado, como o preço pago ao coletor, a demanda e a qualidade do produto, bem como a renda monetária obtida pelos indivíduos são os parâmetros considerados mais importantes. Por fim, para os aspectos sociais, os efeitos na cultura, na qualidade de vida e na organização interna da comunidade foram priorizados. Os profissionais indicam que é viável estabelecer o monitoramento dos parâmetros levantados. / Amazon, non-timber forest products, ecological effects, socioeconomic effects, monitoring.