Contexte :Le conditionnement précédant la greffe de cellules souches hématopoïétiques (CSH) a été associé avec des taux élevés de malnutrition meme à 100 jours après la greffe. Objectif: Cette étude évalua l'impact du conseil nutritionel fournie à la sortie de l'hôpital sur l'état nutritionnel,100 jours après la greffe de CSH (dit T4).Conception: Il s'agissait d'un essai contrôlé randomisé monocentrique. Les patients adultes étaient randomisés à un groupe témoin (GT) recevant des soins habituels et un groupe d'intervention (GI) recevant des conseils nutritionnels mensuels après la sortie de l’hôpital. Le résultat principal était le score de l'évaluation globale subjective générée par le patient (PGSGA) à T4. La malnutrition était évalué aussi par le score de la société américaine de nutrition parentérale et entérale/Académie de nutrition et diététique (AND-ASPEN).Résultats: 52 participants ont été randomisés (août 2016 jusqu'en août 2017) et 46 ont été analysés [65% d'hommes, 63% de greffes autologues, GI (n = 22), GT (n = 24)]. Les deux groupes etaient comparable au moment de randomization.A T4, le pourcentage de patients bien nourris n'était pas significativement différent entre les groupes selon le PGSGA (72% GI vs 43% GT, p = 0,063). Le pourcentage de patients bien nourris selon AND-ASPEN s'est améliorré à T4 dans le GI (50% vs 14%, p = 0,02) et non pas dans le GT par rapport aux valeurs d'admission. A T4, le GI avait un apport de protéines et de calories plus élevé que le GT(p<0.05).Conclusion:Le conseil nutritionnel après la greffe de CSH a amélioré l’apport en protéines et calories ainsi que le score AND-ASPEN mais non pas le score PGSGA. / Background: Conditioning preceding Hematopoietic Stem Cell Transplantation (HSCT) has been associated with elevated rates of malnutrition until 100 days post HSCT.Objective: This study aimed to assess the impact of nutritional counseling provided at hospital discharge on nutritional status 100 days post HSCT (defined as T4). Design: This was a single center randomized controlled trial among adult HSCT patients. Around discharge from the hospital, recruited patients were randomized to a Control Group (CG) receiving usual care and to an Intervention Group (IG) receiving nutritional counseling on a monthly basis post discharge.The primary outcome was the Patient Generated Subjective Global Assessment (PGSGA) scores at T4. Malnutrition was also assessed though the American Society for Parenteral and Enteral Nutrition/ Academy of Nutrition and Dietetics malnutrition score.Results: 52 participants were randomized (August 2016 until August 2017) and 46 were analyzed [65% males, 63% autologous HSCT, IG (n=22), CG (n=24)]. Groups were comparable at randomization. At T4, the percent of well-nourished patients was not significantly different between groups when assessed via PGSGA (72% IG vs. 43% CG, p=0.063).The percent of wellnourished patients as per AND-ASPEN criteria improved in IG at T4 (14% vs. 50%, p=0.02) and remained the same in CG (48% vs. 50%, p=1) compared to admission values. IG had higher protein and caloric intake (p<0.05). Conclusion:Nutritional counseling post HSCT improved patients’ protein and caloric intake and AND-ASPEN score but did not significantly improve PGSGA score.

Innebandy är en växande idrott, som framför allt utövas i Sverige, Finland och Schweiz, men där väldigt lite forskning ännu finns publicerad. Tidigare studier inom ishockey och baseboll har visat att träning med viktmanipulerad utrustning förbättrat bland annat greppstyrka och svinghastigheten av slagträ i baseboll. Annan forskning har visat på att det är en förbättring i det neuromuskulära samspelet snarare än ökad muskelmassa som förbättrat prestationen vid dynamisk motståndsträning. Skotthastigheten anses vara en viktig faktor inom innebandy för prestationen och eftersom det inom baseboll har visats att viktmanipulerad utrustning kan förbättra svinghastigheten så vore det intressant att se om samma resultat kan uppnås inom innebandy. Syftet med studien var att undersöka effekten av innebandyträning med en viktmanipulerad innebandyklubba med avseende på dragskottshastighet och greppstyrka hos manliga innebandyspelare samt undersöka korrelationen mellan dragskottshastighet och greppstyrka. Även testpersonernas subjektiva uppfattning av träningen med den viktmanipuleradeutrustningen undersöktes. Testgruppen bestod av 13 stycken 17-åriga manliga innebandyspelare. Under en sex veckors period genomförde testpersonerna 30 minuter av sin vanliga innebandyträning med den viktmanipulerade klubban (40 gram tyngre) tre gånger i veckan. Dragskotten filmades med en höghastighetskamera (Casio Exilim EX-FH25) med 250 fps och analyserades sedan i Dartfish för att mäta hastigheten. För att fastställa greppstyrkan användes en handdynamometer (Jamar – Baseline Hydraulic Hand Dynamometer). Träningen resulterade i en signifikant skillnad hos testpersonernas greppstyrka i den nedre handen på klubban (p&lt;0,05). Däremot hittades ingen signifikant skillnad för den övre handens greppstyrka eller dragskottshastigheten. Studien visade heller inte på någon korrelation mellan dragskottshastighet och greppstyrka hos testpersonerna. Testpersonerna hade olika åsikter kring hur den extra tyngden påverkade innebandytekniken.De funna resultaten indikerar att träning med viktmanipulerad utrustning i innebandy signifikant förbättrar spelarnas greppstyrka i den nedre handen. Den ökade kraftutvecklingen kan eventuellt förklaras av ett ökat neuromuskulärt samspel. Studien ger en ökad förståelse för hur dynamisk motståndsträning kan implementeras i den dagliga innebandyträningen, vilket kan tillämpas vid planeringen av träningsprogram. / Floorball is a sport with increasing number of participants, which has not been studied extensively according to the literature. Previous studies on ice hockey and baseball have shown that training with weight manipulated equipment improved grip strength and swing speed. Other research has shown that the increased performance with dynamic resistance training rather occurs from the improvements in the neuromuscular facilitation than an increase in muscle mass. In floorball shooting velocity is considered to be an important factor of the performance. Since it has been shown in baseball that training with weight manipulated equipment can improve the bat velocity, it would be interesting to see if the same results can be found in floorball. The purpose of this study was to investigate the effect of grip strength and drag shot velocity in floorball training with a weight manipulated floorball stick. The study also investigated the relationship between grip strength and drag shot velocity. The test subjects’ subjective perception about the training method was also investigated. Thirteen 17-year-old male floorball players participated in the study. During a six weeks period the subjects used the weight manipulated equipment during 30 minutes, three times per week during their regular team practice. 40 grams lead tape was attached to the player's equipment to increase the resistance. The drag shots were filmed with a high speed camera (Casio Exilim EX-FH25) at 250 fps. The drag shot velocity was analyzed in Dartfish. To assess grip strength a hand dynamometer (Jamar - Baseline Hydraulic Hand Dynamometer)was used. The training resulted in a significant increase for the subjects’ grip strength in the lower hand on the stick (p &lt;0,05). The study found no significant difference for the upper hand grip strength or drag shot velocity. No correlation between drag shot velocity and handgripstrength among the subjects were found. Conclusion: The results found in this study indicate that training with weight manipulated equipment can significantly improve the player’s lower hand grip strength. The results can eventually be explained by more effective fiber recruitment in the muscles. Studying floorball can contribute to increase the interest in research on floorball and increase the understanding for how dynamic resistance training can be incorporated in daily floorball practice.

No description available.

Human ageing is accompanied by characteristic metabolic and endocrine changes, including altered hormone profiles, insulin resistance and deterioration of skeletal muscle. Obesity and diabetes may themselves drive an accelerated ageing phenotype. Untangling the causal web between ageing, obesity and diabetes is a priority in order to understand their aetiology and improve prevention and management. The role of biological ageing in determining the risk of obesity and associated conditions has often been examined using mean leukocyte telomere length (LTL), a marker of replicative fatigue and senescence. However, considering phenotypes which represent different domains of biological and functional ageing as exposures for obesity and related traits could allow the elucidation of new understudied phenotypes relevant to cardio-metabolic risk in the wider population. This PhD considers the causal role of (1) hand grip strength (HGS), a marker of overall strength and physical functioning, and (2) resting energy expenditure, an indicator of overall energy metabolism and the major component of daily energy expenditure, in cardio-metabolic risk. I also characterise a new and readily-quantifiable marker of age-related genomic instability, mosaic loss of the Y chromosome (mLOY). Observational evidence implicates each of these phenotypes in cardio-metabolic conditions and intermediate phenotypes. However, it is not possible to infer causality from these observational associations due to confounding and reverse-causality. Mendelian randomisation offers a solution to these limitations and can allow the causal nature of these relationships to be investigated. Using population-based data including UK Biobank, this thesis presents the first large-scale genetic discovery effort for each trait and provides new biological insight into their shared and separate aetiology. I used identified variants to investigate the bidirectional causal associations of each trait with cardio-metabolic outcomes, intermediate phenotypes and other related traits such as frailty and mortality. In total I identified 16 loci for hand grip strength, 19 for mLOY, and one signal for REE. I have shown that HGS is likely to be causally linked to fracture risk, and I have identified the important shared genetic architecture between mLOY, glycaemic traits and cancer. I have also demonstrated that at least one known genetic variant contributing to obesity risk acts partially via reduced REE. Overall the findings of my PhD contribute to our wider understanding of the aetiological role of ageing processes in metabolic dysfunction, and have implications for both basic science and translational applications.

A morbidade por doenças cardiovasculares (DCV) é uma preocupação crescente em Saúde Pública. Um aumento na carga das DCV tem sido recentemente observado, principalmente em países de baixa e média renda, reflexo do aumento da expectativa de vida e do maior tempo de exposição aos fatores risco para as doenças crônicas. O aumento no número de anos vividos com alguma doença crônica tem se tornado uma das principais preocupações em saúde pública, destacando-se, nesse contexto, as doenças cardiovasculares, principal responsável por anos de vida perdidos ajustados por incapacidade em idosos. Dessa forma, a avaliação da carga das doenças crônicas na população, bem como o conhecimento de seus determinantes, representa um importante campo de estudo em Saúde Pública e no planejamento da atenção em saúde. Entretanto, estudos que analisaram tanto a mudança na prevalência de DCV na última década, como os determinantes individuais e contextuais das doenças cardiovasculares em idosos ainda são escassos no Brasil. Esta tese será apresentada sob a forma de três artigos científicos. O primeiro analisou o efeito dos determinantes individuais e contextuais na morbidade por DCV em idosos residentes do município de São Paulo em 2010. Foi observada uma maior presença de DCV entre os idosos que residiam em áreas com desigualdade de renda média-baixa (OR=1,35 IC95 por cento=1,15-1,59), média-alta (OR=2,71 IC95 por cento=2,18-3,36) e alta (OR=1,43 IC95 por cento=1,14-1,79), comparada ao nível mais baixo de desigualdade. Em relação às áreas com menor área verde por habitante, viver em áreas com maior cobertura vegetal esteve significantemente associado a uma menor chance de presença de DCV, mesmo após o ajuste estatístico para os fatores individuais e contextuais. O segundo artigo analisou a mudança na prevalência de DCV entre 2000 e 2010 e sua associação com os fatores socioeconômicos e fatores de risco em idosos. A prevalência de DCV em idosos foi igual a 17,9 por cento em 2000, 22,2 por cento em 2006 e 22,9 por cento em 2010. Em relação ao ano 2000, foi observado um aumento significativo da presença de DCV em 2006 (OR=3,20 IC95 por cento=1,93-5,31) e 2010 (OR=2,98 IC95 por cento=1,51-5,89). A presença de DCV também apresentou associação com maior faixa etária, histórico de tabagismo e presença de diabetes e hipertensão arterial, sendo observada uma associação inversa entre a presença de DCV e a ingestão de álcool. O terceiro artigo analisou a associação entre a força de preensão manual e a morbidade por doença cardiovascular em idosos. Foi observado que uma maior força de preensão manual esteve significativamente associada a uma menor presença de DCV em idosos (OR=0,47 IC95 por cento = 0,24 0,91), mesmo após o controle para as características individuais. / Cardiovascular disease morbidity (CVD) is a growing concern in Public Health. An increase in the burden of CVD has been recently observed, especially in low- and middle-income countries, due to increases in life expectancy and the longer exposure period to risk factors of chronic diseases. The increase of total years lived with a chronic disease is now considered as one of the main public health concerns, especially regarding cardiovascular diseases, the highest contributor to disability-adjusted life years among the elderly. Therefore, the assessment of the total burden of chronic diseases in the population and the identification of its determinants represents an important area of concern in Public Health and healthcare policies. However, studies that have analyzed both the evolution of the CVD prevalence in the last decade and the individual and contextual determinants of cardiovascular diseases among the elderly are still scarce in Brazil. This thesis is presented in the form of three papers. The first one analyzed the effect of individual and contextual determinants of morbidity of CVD in elderly residents of Sao Paulo, Brazil, in 2010. In comparison to elderly residents in areas with the lowest level of income inequality, higher odds of CVD presence was observed among those living in areas in the mediumlow (OR=1.35, 95 per cent CI 1.15 to 1.59), mediumhigh (OR=2.71, 95 per cent CI 2.18 to 3.36) and high (OR=1.43, 95 per cent CI 1.14 to 1.79) quartiles of income inequality. Regarding green spaces, those who live in areas with highest levels of vegetation coverage had a significantly lower risk of CVD, even after controlling for individual and contextual factors. The second paper analyzed the differences in the prevalence of CVD between 2000 and 2010 and its association with socioeconomic factors and risk factors among the elderly. The prevalence of CVD in the elderly was estimated to be 17.9 per cent in 2000, 22.2 per cent in 2006 and 22.9 per cent in 2010. Regarding the prevalence observed in 2000, there was a significant increase in presence of CVD in 2006 (OR = 3.20 95 per centCI = 1.93 to 5.31) and 2010 (OR = 2.98 95 per centCI = 1.51 to 5.89). The presence of CVD was also associated with older age, smoking history, presence of diabetes and hypertension, and an inverse association was observed between CVD presence and alcohol intake. The third paper analyzed the association between grip strength and cardiovascular disease morbidity in the elderly. A significantly lower presence of CVD was observed among the elderly with higher grip strength (OR = 0.47 95 per centCI = 0.24 to 0.91), even after controlling for individual characteristics.

Background: Knowledge of the relationship between fat free mass (FFM) and strength capacity is not only useful in athlete coaching, but may also be important in developing clinical strategies for evaluating health in general populations. Sufficient skeletal muscle mass and strength are important factors for health and physical function. Bioelectrical impedance analysis (BIA) is a popular and clinically useful tool for assessing body composition. However, being able to simultaneously estimate whole body muscle strength without having to perform additional tests may prove useful in evaluating an individual’s health and physical function. Aim: The primary purpose of this study was to quantify the association between total body fat free mass percentage (TBFFM%) and relative strength in the isometric midthigh pull test (IMTP) and grip strength (GS) test in a healthy general young Swedish population. A secondary purpose was to investigate if there are any sex differences.  Methods: The design for this study was cross-sectional. The studied sample represented a general Swedish population of healthy young adults. Participants were asked to participate in testing on one occasion. Three tests were used for collecting data: BIA for data on FFM and both IMTP and hand dynamometer grip strength test for data on maximal force production. All tests were performed in the movement lab on Halmstad University campus. Statistical analyses were done using Pearson’s correlation and linear regression analysis. Results: Participants for this study consisted of healthy females (n=18) and males (n=17) aged 19-39. The primary findings of this study are that there are strong correlations between TBFFM% and relative strength (r = 0.621) in the IMTP test as well as relative GS (r = 0.705) on a whole-group level. The correlation between TBFFM% and relative GS was slightly stronger. Categorized by sex, we found strong positive correlations between TBFFM% and relative IMTP (r = 0.551) and relative GS (r = 0.596) for the female group and moderately strong correlations for the male group (relative IMTP r = 0.411; relative GS  r = 0.422).On a whole-group level, every unit increase in TBFFM% increases relative strength in the IMTP by 0.538N/kgBW (β = 0.538) and relative GS by 0.015 kg/kgBW (β = 0.015). Conclusion: TBFFM% was strongly associated with both relative IMTP strength and relative GS where the association was stronger for females than for males. TBFFM% values may be indicative of an individual's strength, which could be of value in a research setting.

In this bachelor’s thesis, the development and construction of a soft exoskeleton for a human hand is described.The purpose of the project includes evaluating what type of exoskeleton that is most suitable for aiding the user inactivities of daily living and how this exoskeleton can be constructed in order to increase grip strength in the human hand. In addition, the prototype should be portable and not inflict any harm on the user. The necessary theoretical research is thoroughly conducted followed by the construction of the final prototype. The purpose of the project is achieved, resulting in a flexible, portable and safe exoskeleton which with satisfaction can aid the user in its activities of daily living. However, this prototype is limited to exclusively include the thumb and index finger, and in further work the prototype can be developed to include all five fingers of the human hand. / I detta kandidatexamensarbete behandlas utvecklingen och konstruktionen av ett mjukt exoskelett för den mänskliga handen. Syftet med projektet är att undersöka vilken typ av exoskelett som passar bäst för att hjälpa användaren med aktiviteter i det dagliga livet, samt hur detta exoskelett kan konstrueras för att förstärka greppet i handen. Prototypen ska även vara bärbar och inte skada användaren. Den nödvändiga teorin presenteras, följt av konstruktionen av den slutgiltiga prototypen. Syftet med projektet uppfylls och resulterar i ett flexibelt, portabelt och säkert exoskelett som kan hjälpa användaren med aktiviteter i det dagligalivet. Dock är denna prototyp begränsad till att endast inkludera styrning av tummen och pekfingret, och prototypenkan således i framtida arbeten utvecklas till att inkludera samtliga fem fingrar på den mänskliga handen.

Introdução: A sarcopenia é caracterizada pela redução da força e massa muscular (MM), e acompanhada pelo declínio da capacidade funcional, em idosos, e sua associação com dependência para realização das atividades básicas da vida diária (ABVD) tem sido relatada na literatura internacional, entretanto, há escassez de informações sobre o tema no Brasil. Objetivo: Estimar a associação entre sarcopenia e dependência para a realização das ABVD, em idosos domiciliados no município de São Paulo, segundo sexo. Casuística e métodos: Foram analisados idosos ( 60 anos), de ambos os sexos, do Estudo SABE, longitudinal, epidemiológico e de base domiciliar, realizado no município de São Paulo, em 2000 e 2006, e que, em 2000, não apresentaram dependência. A variável sarcopenia foi definida por meio de três componentes: desempenho no teste de sentar e levantar de uma cadeira (SeL), categorizado em baixo (tempo percentil 75, segundo sexo), e normal (< percentil 75); pela força de preensão manual (FPM), categorizada em baixa (força percentil 25, segundo índice de massa corporal e sexo) e normal (> percentil 25); e massa muscular (MM), categorizada em baixa ( percentil 20, segundo sexo) e normal (> percentil 20), sendo diagnosticados sarcopênicos, idosos que apresentaram, simultaneamente, baixo desempenho e baixa MM, ou, então, desempenho normal, mas, baixas FPM e MM. A dependência para a realização das ABVD foi referidas pelos idosos, em 2006, sendo considerando dependentes, aqueles que responderam positivamente, para, pelo menos uma questão referente à dependência. As variáveis de controle foram sexo, grupos etários (60-74 e 75 anos), etnia (caucasianos, asiáticos, outros), número de doenças referidas (1 ou > 1). Resultados: Dos idosos sobreviventes, 799 apresentaram todos os dados necessários ao estudo (60,3 por cento mulheres, 85,6 por cento < 75 anos). Foram identificados como sarcopênicos, em 2000, 8,9 por cento dos idosos (homens = 8,3 por cento ; mulheres = 9,3 por cento ), e dependentes para a realização das ABVD, em 2006, 7 por cento (homens = 6,5 por cento ; mulheres = 7,3 por cento ). Idosos sarcopênicos apresentaram chance 3,13 vezes maior, para dependência (IC 95 por cento 1,67-5,87), em 2006, ajustado pelas demais variáveis, em relação aos não sarcopênicos. Quanto ao sexo, os homens sarcopênicos apresentaram chance 4,12 vezes maior (IC 95 por cento 1,28-13,30), para dependência, em 2006, enquanto as mulheres sarcopênicas apresentaram chance 2,77 vezes maior (IC 95 por cento 1,23-6,24). Conclusão: Aproximadamente 9 por cento dos idosos do município de São Paulo foram identificados como sarcopênicos, em 2000. Idosos sarcopênicos apresentaram chance maior de dependência para a realização das ABVD, em 2006, em particular, os homens / Introduction: Sarcopenia is characterized by reduced muscle mass (MM) and strength, and it is accompanied by a decline in functional capacity in elderly. Its association with dependence to perform activities of daily living (ADL) has been reported in international literature, however,there is limited information about the theme, in Brazil. Purpose: To estimate the association between sarcopenia and dependence to perform ADL, in elderly domiciled in the city of São Paulo, according to gender. Methodology: Elderly ( 60 anos) of both genders, who were not dependent in 2000, from the SABE Survey, a home-based, longitudinal and epidemiologic study, performed in the city of São Paulo, in 2000 and 2006, were analyzed. Sarcopenia was defined by three components: performance in the sit and rise from a chair test (S&R), categorized as low (time 75th percentile according to sex) and normal (<75th percentile); by handgrip strength (HS), categorized as low (strength 25 percentile, according to body mass index and gender) and normal (> 25th percentile); and muscle mass (MM), categorized as low ( 20th percentile, by sex) and normal (> 20th percentile); where diagnosed sarcopenic elderly who had both poor performance and low MM , or normal performance, but low HS and MM. Dependence to perform ADL, referred by the elderly, in 2006, being considered dependents those who answered, positively, for at least, one question related to dependence. Control variables were: sex, age groups (60-74 e 75 anos), ethnicity (caucasian, asian, others), number of referred diseases (1 ou > 1). Results: Of the survivors, 799 presented all data for the study (60.3 per cent women, 85.6 per cent < 75 years old). It was identified as sarcopenic, in 2000, 8.9 per cent of the elderly (men = 8.3 per cent ; women = 9.3 per cent ), and dependents to perform ADL, in 2006, 7 per cent (men = 6.5 per cent ; women = 7.3 per cent ). Those diagnosed with sarcopenia, in 2000, presented an odds ratio 3.13 times higher, for dependence (CI 95 per cent 1.67-5.87), in 2006, adjusted for other variables. According to gender, sarcopenic men presented an odds ratio 4.12 times higher (CI 95 per cent 1.28-13.30), for dependence, in 2006, while sarcopenic women present odds ratio 2.77 times higher (CI 95 per cent 1.23-6.24). Conclusion: Approximately 9 per cent of the elderly in São Paulo were identified as sarcopenic, in 2000. Sarcopenic elderly presented higher chance of dependency to perform ADL in 2006, particularly men

Introdução: A sarcopenia é caracterizada pela redução da força e massa muscular (MM), e acompanhada pelo declínio da capacidade funcional, em idosos, e sua associação com dependência para realização das atividades básicas da vida diária (ABVD) tem sido relatada na literatura internacional, entretanto, há escassez de informações sobre o tema no Brasil. Objetivo: Estimar a associação entre sarcopenia e dependência para a realização das ABVD, em idosos domiciliados no município de São Paulo, segundo sexo. Casuística e métodos: Foram analisados idosos ( 60 anos), de ambos os sexos, do Estudo SABE, longitudinal, epidemiológico e de base domiciliar, realizado no município de São Paulo, em 2000 e 2006, e que, em 2000, não apresentaram dependência. A variável sarcopenia foi definida por meio de três componentes: desempenho no teste de sentar e levantar de uma cadeira (SeL), categorizado em baixo (tempo percentil 75, segundo sexo), e normal (< percentil 75); pela força de preensão manual (FPM), categorizada em baixa (força percentil 25, segundo índice de massa corporal e sexo) e normal (> percentil 25); e massa muscular (MM), categorizada em baixa ( percentil 20, segundo sexo) e normal (> percentil 20), sendo diagnosticados sarcopênicos, idosos que apresentaram, simultaneamente, baixo desempenho e baixa MM, ou, então, desempenho normal, mas, baixas FPM e MM. A dependência para a realização das ABVD foi referidas pelos idosos, em 2006, sendo considerando dependentes, aqueles que responderam positivamente, para, pelo menos uma questão referente à dependência. As variáveis de controle foram sexo, grupos etários (60-74 e 75 anos), etnia (caucasianos, asiáticos, outros), número de doenças referidas (1 ou > 1). Resultados: Dos idosos sobreviventes, 799 apresentaram todos os dados necessários ao estudo (60,3 por cento mulheres, 85,6 por cento < 75 anos). Foram identificados como sarcopênicos, em 2000, 8,9 por cento dos idosos (homens = 8,3 por cento ; mulheres = 9,3 por cento ), e dependentes para a realização das ABVD, em 2006, 7 por cento (homens = 6,5 por cento ; mulheres = 7,3 por cento ). Idosos sarcopênicos apresentaram chance 3,13 vezes maior, para dependência (IC 95 por cento 1,67-5,87), em 2006, ajustado pelas demais variáveis, em relação aos não sarcopênicos. Quanto ao sexo, os homens sarcopênicos apresentaram chance 4,12 vezes maior (IC 95 por cento 1,28-13,30), para dependência, em 2006, enquanto as mulheres sarcopênicas apresentaram chance 2,77 vezes maior (IC 95 por cento 1,23-6,24). Conclusão: Aproximadamente 9 por cento dos idosos do município de São Paulo foram identificados como sarcopênicos, em 2000. Idosos sarcopênicos apresentaram chance maior de dependência para a realização das ABVD, em 2006, em particular, os homens / Introduction: Sarcopenia is characterized by reduced muscle mass (MM) and strength, and it is accompanied by a decline in functional capacity in elderly. Its association with dependence to perform activities of daily living (ADL) has been reported in international literature, however,there is limited information about the theme, in Brazil. Purpose: To estimate the association between sarcopenia and dependence to perform ADL, in elderly domiciled in the city of São Paulo, according to gender. Methodology: Elderly ( 60 anos) of both genders, who were not dependent in 2000, from the SABE Survey, a home-based, longitudinal and epidemiologic study, performed in the city of São Paulo, in 2000 and 2006, were analyzed. Sarcopenia was defined by three components: performance in the sit and rise from a chair test (S&R), categorized as low (time 75th percentile according to sex) and normal (<75th percentile); by handgrip strength (HS), categorized as low (strength 25 percentile, according to body mass index and gender) and normal (> 25th percentile); and muscle mass (MM), categorized as low ( 20th percentile, by sex) and normal (> 20th percentile); where diagnosed sarcopenic elderly who had both poor performance and low MM , or normal performance, but low HS and MM. Dependence to perform ADL, referred by the elderly, in 2006, being considered dependents those who answered, positively, for at least, one question related to dependence. Control variables were: sex, age groups (60-74 e 75 anos), ethnicity (caucasian, asian, others), number of referred diseases (1 ou > 1). Results: Of the survivors, 799 presented all data for the study (60.3 per cent women, 85.6 per cent < 75 years old). It was identified as sarcopenic, in 2000, 8.9 per cent of the elderly (men = 8.3 per cent ; women = 9.3 per cent ), and dependents to perform ADL, in 2006, 7 per cent (men = 6.5 per cent ; women = 7.3 per cent ). Those diagnosed with sarcopenia, in 2000, presented an odds ratio 3.13 times higher, for dependence (CI 95 per cent 1.67-5.87), in 2006, adjusted for other variables. According to gender, sarcopenic men presented an odds ratio 4.12 times higher (CI 95 per cent 1.28-13.30), for dependence, in 2006, while sarcopenic women present odds ratio 2.77 times higher (CI 95 per cent 1.23-6.24). Conclusion: Approximately 9 per cent of the elderly in São Paulo were identified as sarcopenic, in 2000. Sarcopenic elderly presented higher chance of dependency to perform ADL in 2006, particularly men

Syfte Syftet med föreliggande studie var att försöka klargöra om stötvågsbehandling har någon effekt på smärta och handgreppstyrka hos patienter med lateral epikondylalgia. Frågeställningar 1. Har stötvågsbehandling någon effekt på smärta hos patienter med lateral epikondylalgia, i så fall vilken? 2. Har stötvågsbehandling någon effekt på handgreppsstyrka hos patienter med lateral epikondylalgia, i så fall vilken? Metod Sökning av litteratur utfördes i PubMed, Cochrane, Cinahl och PEDro. Detta resulterade i 14 artiklar, som granskades och bedömdes enligt PEDro Scale. Poängbedömningen utifrån PEDro Scale omsattes till Statens Beredning för medicinsk Utrednings (SBU) mall för bevisvärde. Utifrån artiklarnas sammantagna bevisvärde bestämdes evidensnivån enligt SBU:s fyra nivåer. Resultat Enligt GRADE-systemet förelåg det ett starkt vetenskapligt belägg för att stötvågsbehandling har en smärtlindrande effekt vid lateral epikondylalgia. Studier av likartad vetenskaplig kvalitet påvisar motsägande resultat avseende om stötvågsbehandling är bättre än placebo, kortison eller tenotomi. Detta innebär att det vetenskapliga underlaget är otillräckligt och att mer forskning behövs. Enligt GRADE-systemet förelåg det ett starkt vetenskapligt belägg för att stötvågsbehandling leder till förbättrad handgreppsstyrka vid lateral epikondylalgia. Vidare förelåg det ett starkt vetenskapligt belägg för att stötvågsbehandling inte är bättre än någon annan behandling gällande ökning av handgreppsstyrka vid lateral epikondylalgia. Slutsats Stötvågsbehandling har en smärtlindrande effekt hos patienter med lateral epikondylalgia. Det finns dock ingen evidens för att stötvågsbehandling är bättre ur smärthänseende än någon annan behandling såsom placebo, kortison eller tenotomi. Stötvågsbehandling leder till förbättrad handgreppsstyrka men är inte bättre än placebo, kortison eller tenotomi på att öka handgreppsstyrkan hos patienter med lateral epikondylalgia. / Aim The aim of the present study was to try to find out whether shock wave therapy has any effect on pain and grip strength in patients with lateral epicondylitis. Objectives 1. Does shock wave therapy reduce pain in patients with lateral epicondylitis? 2. Does shock wave therapy improve grip strength in patients with lateral epicondylitis? Method A literature review was performed in the databases PubMed, Cochrane, Cinahl and PEDro. Fourteen articles were found and critically reviewed. These articles were scored according to the PEDro scale and the scores were translated into a scale of evidence by the Statens Beredning för medicinsk Utredning (SBU) and the level of evidence was determined based on the four different grades presented by the SBU. Results According to the GRADE-system there was a strong scientific evidence for a reduction of pain using shock wave therapy in patients with lateral epicondylitis. Contradictory results whether shock wave therapy was better than placebo, corticosteoroid injection or tenotomy have been reported in studies of similar scientific quality. This means that more research is needed in this field. According to the GRADE-system there was a strong scientific evidence for an improvement of grip strength using shock wave therapy. Furthermore, there was a strong scientific evidence for that shock wave is not better than any other therapy in terms of improving grip strength in patients with lateral epicondylitis. Conclusion Shock wave therapy reduces pain in patients with lateral epicondylitis. There is, however, no evidence for shock wave therapy to be superior to any other treatment such as placebo, corticosteoroid injection or tenotomy. Shock wave therapy improves grip strenght but is not better than placebo, corticoidsteroid injection or tenotomy in increasing grip strength in patients with lateral epicondylitis.