Master of Public Health - MPH / Tuberculosis (TB) continues to be a major cause of ill health and the leading cause of death from a single infectious agent worldwide. Furthermore, young children, especially those under five years old and infants, are at risk of developing more severe forms of TB. TB cases continue to cluster among disadvantaged groups such as the poor whose lives are characterised by adverse living conditions. Defaulting from treatment poses a severe threat to children’s health because untreated TB or breaks in treatment could lead to a child developing more severe forms of TB, or worse, could result in mortality. Currently, long-term hospitalisation has the most successful TB treatment outcomes. Therefore, to ensure compliance, children are taken out of their social environment and admitted to hospital. However, being separated from one’s family, especially at a crucial stage of development, could have long-terms effects on the child’s development. The study explored, factors influencing access to care that caregivers of children; who are five years and younger, who received prolonged treatment at a specialised TB hospital in the Western Cape, South Africa experienced. A qualitative approach allowed the researcher to use personal interactions as a focus for studies and was suitable when aiming to understand health behaviour in its everyday context as experienced by the participant. The study results indicated the factors that enable caregiver visitation, is largely dependent on availability of finances. Furthermore, the hospital itself was identified as being accommodating with regards to visiting hours, telephonic calls and served as important mediator between health service provider, the children, their caregivers and the rest of the staff. Visitation depended on availability of finances, and this was the main barrier that was identified by caregivers. The challenges that hampered visitation were unemployment, lack of access to private and public transport and challenges related to farm-workers. A large number of caregivers work on farms in the Cape Winelands and many of them are dependent on seasonal work which results in inconsistent income. This limited availability of finances for visitation. Furthermore, the working conditions, long shifts and lack of employment benefits which were associated with farming, prevented caregivers from visiting. This study revealed that there are a series of factors which influence access to care of caregivers; this is especially the case in children hospitalised for TB. These factors need to be considered by policy makers as well as the Specialised Tuberculosis facility when dealing with children under five as the best way to ensure that treatment is completed through hospitalisation. Therefore, the strategies to assist families of children with TB need to be explored to assist in the continuity of care as well as the child’s development.

Magister Artium (Social Work) - MA(SW) / Recovery from traumatic brain injury (TBI) can be a lengthy and challenging process for survivors, their families, and health and welfare services. Globally, South Africa has the second-highest prevalence of TBI that is due to road traffic accidents. The growing challenges for TBI survivors are the financial constraints, health implications, and the psychosocial support required by survivors of TBI and their families, which impacts family reintegration, post-hospitalisation. The aim of the study was to understand the challenges experienced by TBI survivors with regards to the psychosocial support services for family reintegration. A qualitative approach, using an exploratory-descriptive design was used. The person-centred perspective was chosen as a theoretical framework.

Contexte : Une tentative de suicide antérieure et les troubles mentaux constituent d’importants facteurs de risque de suicide. Les services de santé ont un rôle important à jouer en matière de prévention. Objectif : Analyser les patrons de recours aux services à des fins de santé mentale avant et après une hospitalisation pour tentative de suicide chez les résidents montréalais qui ont reçu un diagnostic de schizophrénie ou de dépression. Méthode : Les données proviennent de la banque médico administrative jumelée de l’Agence de Montréal. Les caractéristiques des patients et les taux de contacts avec les services trois mois avant et après l’hospitalisation index furent comparées. L’échantillon représentatif compte 525 Montréalais hospitalisés à la suite d’une tentative de suicide (avr. 2003-déc. 2004) qui ont reçu un diagnostic de schizophrénie ou de dépression. Résultats : Le recours aux services a augmenté de manière significative suivant l’hospitalisation index. Les patients déjà en contact avec les services et les hommes avec comorbidité en termes d’abus de substances semblent en contact avec les services au cours des trois mois suivant leur hospitalisation contrairement aux femmes avec comorbidité. Le profil « urgence » de recours aux services semble prédire une absence de recours aux services. Conclusions : Les services de santé répondent aux tentatives de suicide, particulièrement chez les hommes avec troubles d’abus de substances. Cependant, des interventions sont requises en vue d’améliorer la coordination des services, principalement pour les personnes qui se présentent l’urgence, les femmes avec troubles d’abus de substances et les patients en marge du système avant leur hospitalisation. / Background: Mental health disorders and suicide attempts are important risk factors for suicide. Health care services have an important role to play in preventing these deaths. Objective: To analyze patterns of service use for a mental health purpose before and after a hospitalisation following a suicide attempt among Montreal’s residents diagnosed with schizophrenia or depression. Method: Data was taken from the linked administrative database of the Montreal’s Agency. Patient’ characteristics and contacts rates with services three months before and after the index hospitalisation were compared. The representative sample includes all 525 patients living in Montreal, who were hospitalised following a suicide attempt (Apr. 2003-Dec. 2004) and who were diagnosed with schizophrenia or depression. Results: Intensity of care increased significantly after the index hospitalisation. Patients in contact with services before and comorbidity of substance abuse disorder among men predicted a contact with services for a mental health purpose three months after the index hospitalisation contrary to women with comorbidity. Besides, the emergency room profile of service use predicted a lack of service utilisation. Conclusions: Health services respond to suicide attempts, including in men with substance abuse. However, there is an opportunity for increased aftercare coordination for suicidal individuals, in particular for those presenting at the emergency room, those with no previous contact with services and for women with substance abuse.

Contexte : Une tentative de suicide antérieure et les troubles mentaux constituent d’importants facteurs de risque de suicide. Les services de santé ont un rôle important à jouer en matière de prévention. Objectif : Analyser les patrons de recours aux services à des fins de santé mentale avant et après une hospitalisation pour tentative de suicide chez les résidents montréalais qui ont reçu un diagnostic de schizophrénie ou de dépression. Méthode : Les données proviennent de la banque médico administrative jumelée de l’Agence de Montréal. Les caractéristiques des patients et les taux de contacts avec les services trois mois avant et après l’hospitalisation index furent comparées. L’échantillon représentatif compte 525 Montréalais hospitalisés à la suite d’une tentative de suicide (avr. 2003-déc. 2004) qui ont reçu un diagnostic de schizophrénie ou de dépression. Résultats : Le recours aux services a augmenté de manière significative suivant l’hospitalisation index. Les patients déjà en contact avec les services et les hommes avec comorbidité en termes d’abus de substances semblent en contact avec les services au cours des trois mois suivant leur hospitalisation contrairement aux femmes avec comorbidité. Le profil « urgence » de recours aux services semble prédire une absence de recours aux services. Conclusions : Les services de santé répondent aux tentatives de suicide, particulièrement chez les hommes avec troubles d’abus de substances. Cependant, des interventions sont requises en vue d’améliorer la coordination des services, principalement pour les personnes qui se présentent l’urgence, les femmes avec troubles d’abus de substances et les patients en marge du système avant leur hospitalisation. / Background: Mental health disorders and suicide attempts are important risk factors for suicide. Health care services have an important role to play in preventing these deaths. Objective: To analyze patterns of service use for a mental health purpose before and after a hospitalisation following a suicide attempt among Montreal’s residents diagnosed with schizophrenia or depression. Method: Data was taken from the linked administrative database of the Montreal’s Agency. Patient’ characteristics and contacts rates with services three months before and after the index hospitalisation were compared. The representative sample includes all 525 patients living in Montreal, who were hospitalised following a suicide attempt (Apr. 2003-Dec. 2004) and who were diagnosed with schizophrenia or depression. Results: Intensity of care increased significantly after the index hospitalisation. Patients in contact with services before and comorbidity of substance abuse disorder among men predicted a contact with services for a mental health purpose three months after the index hospitalisation contrary to women with comorbidity. Besides, the emergency room profile of service use predicted a lack of service utilisation. Conclusions: Health services respond to suicide attempts, including in men with substance abuse. However, there is an opportunity for increased aftercare coordination for suicidal individuals, in particular for those presenting at the emergency room, those with no previous contact with services and for women with substance abuse.

En réponse aux contraintes économiques mais aussi aux évolutions démographique et technologique, le secteur de la santé a commencé à évoluer entraînant dans sa dynamique l'ensemble des établissements de santé les incitant à innover et à se réorganiser. <br />Dans ce travail de recherche, l'intérêt est porté sur les établissements d'hospitalisation à domicile (HAD) en raison du paradoxe qui les caractérisent : bien que créés il y a une cinquantaine d'années, ces établissements se sont révélées, durant cette dernière décennie, comme moyen possible de réduction des dépenses du domaine de la santé tout en satisfaisant une bonne qualité de service. En outre, à la différence des établissements hospitaliers, les problématiques existantes dans les établissements d'HAD n'aiguisent pas suffisamment la curiosité de la communauté du génie industriel en général et celle de la recherche opérationnelle en particulier.<br />Dans cette thèse, nous nous intéressons à trois problématiques distinctes issues du domaine d'HAD. La première concerne l'activité principale des professionnels de santé à savoir la gestion des projets thérapeutiques des patients. Une extension du projet thérapeutique est présentée permettant d'intégrer l'aspect organisationnel des prestations de soins fournissant ainsi un outil d'aide à la coordination des acteurs impliqués dans la prise en charge des patients. A partir de cette étape, il nous a été possible d'avoir une vision multi-projets, et de modéliser de la sorte l'ensemble des fonctions de type gestion des opérations propres à un établissement d'HAD. Cette modélisation émane en partie d'une étude comparative entre quatre établissements d'HAD. En se basant sur les principales fonctions identifiées, une cartographie des décisions est dressée adoptant différents niveaux d'horizons temporels. Cette visibilité sur le système décisionnel nous a éclairé quant aux problématiques critiques intéressant les établissements d'HAD. La dernière problématique porte sur la production et la distribution des médicaments anticancéreux dans le cadre d'une chimiothérapie à domicile. Le problème s'apparente à un problème du voyageur de commerce couplé à un problème d'ordonnancement.

Le sujet de thèse s’intéresse à la chimiothérapie à domicile qui est l’effet combiné de l’augmentation des patients atteints du cancer et du succès de l’hospitalisation à domicile. Nous proposons à travers ce mémoire de thèse des solutions appropriées au pilotage de la chaîne de prise en charge de la chimiothérapie à domicile permettant d’évaluer et d’améliorer la performance de celle-ci. La première partie présente le contexte socio-économique de la chimiothérapie à domicile, ainsi que les contraintes réglementaires et organisationnelles pour sa mise en œuvre. La deuxième partie précise les spécificités d’une chaîne de prise en charge de la chimiothérapie à domicile et les problématiques liées à cette chaîne basée sur une revue de la littérature. La troisième partie se focalise sur la modélisation des processus de prise en charge de la chimiothérapie à domicile à partir d’un important travail de terrain. Un modèle générique de la chimiothérapie à domicile est dégagé du travail de modélisation qui constitue le fondement d’une proposition de classification des pratiques de la chimiothérapie à domicile. Un diagnostic individuel et comparatif des différentes familles d’approches sont également présentés dans cette partie. La quatrième partie présente les différentes applications développées pour évaluer et améliorer la performance de la chaîne de prise en charge de la chimiothérapie à domicile. En conclusion, cette thèse apporte une première contribution à la généralisation de la pratique de la chimiothérapie à domicile et au développement d’outils d’aide aux pilotages destinés à l’amélioration de sa réalisation / This thesis deals with chemotherapy at home which is the fruit of increasing cancer patients and successful development of home care services. We present in this thesis appropriate solutions to evaluate and improve management performance of chemotherapy at home network. The first part concerns the socioeconomic context of chemotherapy at home, as well as its legal and organizational constraints. The second part outlines specificities and related issues of chemotherapy at home based on a literature review. The third part focuses on chemotherapy at home process modeling depending on an important field work. A generic model of chemotherapy at home is abstracted, which is the basis of a chemotherapy at home practices classification that we proposed. An individual analysis and a comparative analysis of chemotherapy at home approaches are also proposed in this part. The fourth part presents different solutions that we developed to evaluate and improve the management performance of chemotherapy at home network. In conclusion, this thesis provides an initial contribution to promote chemotherapy at home practices and to develop management support tools for its implementation

Esta tese estuda o cumprimento das medidas de segurança no Brasil contemporâneo, a fim de compreender o impacto da Reforma Psiquiátrica e da Lei nacional 10.216/01 no campo dos considerados loucos criminosos. Para tanto, apresento a lógica periculosista voltada a esse grupo de sujeitos vulneráveis, examinando a maneira como ela se constitui e se mantém. Tendo como referencial teórico fundamentalmente as obras de Foucault e de Agamben, faço o mapeamento dos mecanismos atuantes no campo do considerado louco infrator que autorizam e legitimam as mais diversas violências contra os internos dos manicômios judiciários brasileiros. Esta tese, pois, centra-se nas seguintes questões: que mecanismos existem nos campos das práticas punitivas que anulam as conquistas realizadas no campo da saúde mental (Reforma Psiquiátrica)? Como as expressivas mudanças trazidas pela Lei 10.216/01 têm repercutido na forma de lidar com os loucos infratores? A partir da obra Os Anormais, de Foucault, discuto como ocorre a fusão entre as ciências jurídicas e psiquiátricas voltando-se a esse sujeito que não é nem considerado propriamente doente nem propriamente criminoso, mas um anormal. Para realizar tal objetivo, foram analisados materiais como: entrevista com Ernesto Venturini, anotações realizadas após visitas ao IPFMC de Porto Alegre, censo 2011 sobre hospitais psiquiátricos judiciários no país, Dados do Departamento Penitenciário Nacional (DEPEN), Parecer sobre Medidas de Segurança e Hospitais de Custódia e Tratamento Psiquiátrico sob a Perspectiva da Lei 10.216/01, elaborado pela Procuradoria Federal dos Direitos do Cidadão (PFDC) do Ministério Público Federal (MPF), Lei da Reforma Psiquiátrica brasileira (Lei 10.216/01) e Lei da Reforma Psiquiátrica italiana (Lei 180). Parte da investigação foi realizada na Universidade de Bologna, Itália, sob a coorientação do criminólogo Massimo Pavarini, para compreender de que maneira o país vem tratando o cumprimento das medidas de segurança e como a Reforma Psiquiátrica tem propugnado mudanças no tratamento do considerado louco infrator. Como resultado da tese aponto que a união entre ambos os campos do saber gera um terceiro discurso, algo distinto daquilo que sozinhas produzem as ciências jus e as ciências psi. Já que não há uma epistemologia própria, nas práticas voltadas a esses indivíduos não há uma limitação adequada, não há freios, porque também não há uma ciência definida, mas o entrelaçamento entre duas. E se é assim, o que ocorre é a legitimação de condutas violadoras de direitos que atuam sobre o considerado louco infrator, muitas vezes, de maneira inclusive letal. Pessoas amontoadas em manicômios judiciários, diferenciadas dos demais considerados loucos pelo fato de terem praticado um crime, e nas quais é possível incidir não porque a ciência médica ou jurídica simplesmente determine, mas porque a união desses saberes cria um discurso próprio voltado a um sujeito próprio chamado de anormal. / This thesis analyses the implementation of compulsory hospitalisation in Contemporary Brazil in order to understand the impact of the Psychiatric Reform and the National Law 10.216/01 on the considered insane offender field. Therefore, it presents the dangerous logic focusing on this group of vulnerable subjects, observing how it constitutes and maintains. Through the guidance of Foucault and Agamben’s works, it maps the mechanisms operating in the considered insane offender field, which authorize and legitimize the most diverse violence against inmates in Brazilian legal mental institutions. The central question of this thesis is, therefore, what are the existing mechanisms in the punitive practices field that nullify the achievements made in the mental health field (psychiatric reform)? How have the significant changes introduced by the Law 10.216/01 been reflecting in dealing with insane offenders? From Foucault’s Os Anormais book, I discuss how the merger between legal and psychiatric sciences occurs, focusing on this subject that is neither properly considered mentally ill nor strictly criminal, but an abnormal. To accomplish this objective, many resources were analysed, such as an interview with Ernesto Venturini; notes made after visits to IPFMC in Porto Alegre; the 2011 census on legal mental institutions in the country; data from the Departamento Penitenciário Nacional (DEPEN); researches on compulsory hospitalisation and Custody Hospitals and Psychiatric Treatment under the Law 10.216/01, carried out by the Federal Attorney for Citizens' Rights (PFDC) of the Federal Public Ministry (MPF), the Brazilian Psychiatric Law Reform (Law 10.216/01) and the Italian Psychiatric Law Reform (Act 180). Part of this research took place at the University of Bologna, Italy, under the co-direction of the criminologist Massimo Pavarini, in order to understand how the country has been dealing with the compliance of the compulsory hospitalisation and how the Psychiatric Reform has advocated changes in the considered insane offender treatment. As a result, this thesis states that the union between the two fields of knowledge generates a third stream/speech, something different from what the jus sciences and the psi sciences produce alone. Since there is not a specific epistemology, practices aimed at these individuals do not have a limitation; there are no brakes, because there is not a well-defined science, but a merge between those two. And, as consequence, what eventually occurs is the legitimation of conducts that violate rights, acting against the considered insane offender, often in lethal ways. People crowded in legal mental institutions, differed by the other so-called "crazy people" just by the fact of having committed a crime. The law is applied to them not by imposition of medical science or legal science, but because the union of these two fields creates its own discourse, which is addressed to a person considered abnormal.

La recherche opérationnelle (RO) joue un rôle important dans les systèmes de santé. Au cours des dernières années, l'hospitalisation à domicile comme les hôpitaux de réhabilitation ont émergé pour pallier aux coûts du système de santé et à la qualité de vie des patients. Dans les secteurs de la réhabilitation, la gestion des soins de santé est sous-développée et la plupart des hôpitaux de réhabilitation sont gérés uniquement par l’expérience. Dans cette thèse, nous traitons d'abord le problème de la planification des traitements dans les hôpitaux de réhabilitation afin de les optimiser. Notre travail vise à réduire le temps d’attente des patients hospitalisés et ainsi améliorer leur satisfaction. Afin de résoudre efficacement ce problème de planification de traitements complexes, nous proposons une approche basée sur un algorithme de recherche hybride de coucou qui est testée et validée dans un cas réel. Nous nous intéressons ensuite à l'hospitalisation à domicile qui constitue un autre problème réel compte tenu du vieillissement de la population. Dans la plupart des régions, un nombre croissant d’organisations à but lucratif et à but non lucratif s’associent pour offrir des soins aux patients. Elles ont tendance à atteindre un niveau hospitalier tant en quantité et qu'en qualité avec une flexibilité accrue par rapport aux services hospitaliers. Nous étudions les problèmes de planification et d'acheminement des soins à domicile en tenant compte de nombreuses contraintes liées à la fois aux patients et aux soignants. Le problème est un scénario pratique motivé et vise à minimiser les coûts d'exploitation totaux. Nous utilisons le solveur commercial Gurobi pour résoudre et valider le modèle avec des données réelles. / Operations research (OR) plays an important role in healthcare system. In recent years, rehabilitation hospitals have been emerging to meet the increasing needs for rehabilitation services due to the ageing population trend. However, the healthcare management in rehabilitation sectors is undeveloped and most of the rehabilitation hospitals (departments) are managed by experience. In this thesis, we deal with a treatment scheduling problem in rehabilitation hospitals. The objective is to facilitate the scheduling process. More importantly, our work aims at reducing the waiting time of inpatients so as to improve inpatients’ satisfactions. In order to solve the complex treatment scheduling problem efficiently, we propose an approach based on a hybrid cuckoo search algorithm which is tested and validated in a real case. Moreover, home healthcare (HHC) is another real-world issue considering the aggravating trend of ageing population. In most areas, an increasing number of social-profit & non-profit organizations are joining in providing healthcare services to patients at their homes and it has a tendency to reach the hospital-level in both quantity and quality for the added flexibility than hospital's service. We investigate home healthcare scheduling and routing problem with consideration of many real-life factors, especially lunch break requirement. The problem is practical scenario motivated and aims at minimizing the total operating cost. We use the commercial solver Gurobi to solve and validate the model with real data.

In the past decades there has been an improvement in the medical treatment of children born preterm or with reduced foetal growth. This has resulted in a much higher survival rate of these children, but also in a higher number of surviving children with chronic conditions. These changes have, in turn, increased interest in investigating the connection between birth-characteristics and outcomes in later life. The overall aim of the present thesis was to study the relations between birth-characteristics, subsequent hospitalisations, and childbearing by means of data available in Swedish population-based registries. The study population in this thesis consisted of women (and men in Paper III) born in 1973-75 according to the Medical Birth Register and the Total Population Register. Information available in other registries, such as the Hospital Discharge Register, was obtained by individual record linkage. In Paper I, 148,281 women, alive and living in Sweden at 13 years of age, were included. Of the women, 4.1% were born preterm and 5.4% were born small for gestational age, and approximately 30% of all women had given birth between 13 and 27 years of age. We found that reduced foetal growth and possibly preterm birth were related to the likelihood of giving birth during the study period. The intergenerational effects of preterm birth and reduced foetal growth were investigated in Paper II and the study population consisted of 38,720 mother-offspring pairs. An intergenerational effect of reduced foetal growth was found, and reduced foetal growth in the mother also increased the risk for preterm birth in the child. Paper III was concerned with 304,275 men and women living in Sweden at 13 years of age. Of these men and women, 30% were hospitalised during adolescence and early adulthood (i.e. between 12 and 23 years of age). We found that men and women born small for gestational age or preterm were more likely to be hospitalised, and that those born small for gestational age seemed to be more at risk compared to those born preterm. Finally, in Paper IV, the relation between hospitalisations during adolescence and the likelihood of giving birth was studied in 142,998 women living in Sweden at 20 years of age. We found that a majority of the causes of hospitalisation during adolescence were positively connected to the likelihood of giving birth between 20 and 27 years of age. The relations presented in Papers I-IV were evident although socio-economic characteristics were adjusted for.

Texte remanié de: Thèse d'université--Santé publique--Aix-Marseille 2, 2004. Titre de soutenance : La prise en charge de la fin de vie dans le cadre de l'hospitalisation à domicile : étude qualitative auprès des patients, de leur famille et des soignants. / Bibliogr. et webliogr. p. 253-258.