Thèse de doctorat : Médecine : Nancy 1 : 2006. / Titre provenant de l'écran-titre.

Reproduction de : Thèse d'exercice : Médecine. Médecine générale : Paris 12 : 2008. / Titre provenant de l'écran-titre. Bibliogr. f. 61-66.

Le sujet de thèse s'intéresse à la chimiothérapie à domicile qui est l'effet combiné de l'augmentation des patients atteints du cancer et du succès de l'hospitalisation à domicile. Nous proposons à travers ce mémoire de thèse des solutions appropriées au pilotage de la chaîne de prise en charge de la chimiothérapie à domicile permettant d'évaluer et d'améliorer la performance de celle-ci. La première partie présente le contexte socio-économique de la chimiothérapie à domicile, ainsi que les contraintes réglementaires et organisationnelles pour sa mise en œuvre. La deuxième partie précise les spécificités d'une chaîne de prise en charge de la chimiothérapie à domicile et les problématiques liées à cette chaîne basée sur une revue de la littérature. La troisième partie se focalise sur la modélisation des processus de prise en charge de la chimiothérapie à domicile à partir d'un important travail de terrain. Un modèle générique de la chimiothérapie à domicile est dégagé du travail de modélisation qui constitue le fondement d'une proposition de classification des pratiques de la chimiothérapie à domicile. Un diagnostic individuel et comparatif des différentes familles d'approches sont également présentés dans cette partie. La quatrième partie présente les différentes applications développées pour évaluer et améliorer la performance de la chaîne de prise en charge de la chimiothérapie à domicile. En conclusion, cette thèse apporte une première contribution à la généralisation de la pratique de la chimiothérapie à domicile et au développement d'outils d'aide aux pilotages destinés à l'amélioration de sa réalisation

No description available.

Esta tese estuda o cumprimento das medidas de segurança no Brasil contemporâneo, a fim de compreender o impacto da Reforma Psiquiátrica e da Lei nacional 10.216/01 no campo dos considerados loucos criminosos. Para tanto, apresento a lógica periculosista voltada a esse grupo de sujeitos vulneráveis, examinando a maneira como ela se constitui e se mantém. Tendo como referencial teórico fundamentalmente as obras de Foucault e de Agamben, faço o mapeamento dos mecanismos atuantes no campo do considerado louco infrator que autorizam e legitimam as mais diversas violências contra os internos dos manicômios judiciários brasileiros. Esta tese, pois, centra-se nas seguintes questões: que mecanismos existem nos campos das práticas punitivas que anulam as conquistas realizadas no campo da saúde mental (Reforma Psiquiátrica)? Como as expressivas mudanças trazidas pela Lei 10.216/01 têm repercutido na forma de lidar com os loucos infratores? A partir da obra Os Anormais, de Foucault, discuto como ocorre a fusão entre as ciências jurídicas e psiquiátricas voltando-se a esse sujeito que não é nem considerado propriamente doente nem propriamente criminoso, mas um anormal. Para realizar tal objetivo, foram analisados materiais como: entrevista com Ernesto Venturini, anotações realizadas após visitas ao IPFMC de Porto Alegre, censo 2011 sobre hospitais psiquiátricos judiciários no país, Dados do Departamento Penitenciário Nacional (DEPEN), Parecer sobre Medidas de Segurança e Hospitais de Custódia e Tratamento Psiquiátrico sob a Perspectiva da Lei 10.216/01, elaborado pela Procuradoria Federal dos Direitos do Cidadão (PFDC) do Ministério Público Federal (MPF), Lei da Reforma Psiquiátrica brasileira (Lei 10.216/01) e Lei da Reforma Psiquiátrica italiana (Lei 180). Parte da investigação foi realizada na Universidade de Bologna, Itália, sob a coorientação do criminólogo Massimo Pavarini, para compreender de que maneira o país vem tratando o cumprimento das medidas de segurança e como a Reforma Psiquiátrica tem propugnado mudanças no tratamento do considerado louco infrator. Como resultado da tese aponto que a união entre ambos os campos do saber gera um terceiro discurso, algo distinto daquilo que sozinhas produzem as ciências jus e as ciências psi. Já que não há uma epistemologia própria, nas práticas voltadas a esses indivíduos não há uma limitação adequada, não há freios, porque também não há uma ciência definida, mas o entrelaçamento entre duas. E se é assim, o que ocorre é a legitimação de condutas violadoras de direitos que atuam sobre o considerado louco infrator, muitas vezes, de maneira inclusive letal. Pessoas amontoadas em manicômios judiciários, diferenciadas dos demais considerados loucos pelo fato de terem praticado um crime, e nas quais é possível incidir não porque a ciência médica ou jurídica simplesmente determine, mas porque a união desses saberes cria um discurso próprio voltado a um sujeito próprio chamado de anormal. / This thesis analyses the implementation of compulsory hospitalisation in Contemporary Brazil in order to understand the impact of the Psychiatric Reform and the National Law 10.216/01 on the considered insane offender field. Therefore, it presents the dangerous logic focusing on this group of vulnerable subjects, observing how it constitutes and maintains. Through the guidance of Foucault and Agamben’s works, it maps the mechanisms operating in the considered insane offender field, which authorize and legitimize the most diverse violence against inmates in Brazilian legal mental institutions. The central question of this thesis is, therefore, what are the existing mechanisms in the punitive practices field that nullify the achievements made in the mental health field (psychiatric reform)? How have the significant changes introduced by the Law 10.216/01 been reflecting in dealing with insane offenders? From Foucault’s Os Anormais book, I discuss how the merger between legal and psychiatric sciences occurs, focusing on this subject that is neither properly considered mentally ill nor strictly criminal, but an abnormal. To accomplish this objective, many resources were analysed, such as an interview with Ernesto Venturini; notes made after visits to IPFMC in Porto Alegre; the 2011 census on legal mental institutions in the country; data from the Departamento Penitenciário Nacional (DEPEN); researches on compulsory hospitalisation and Custody Hospitals and Psychiatric Treatment under the Law 10.216/01, carried out by the Federal Attorney for Citizens' Rights (PFDC) of the Federal Public Ministry (MPF), the Brazilian Psychiatric Law Reform (Law 10.216/01) and the Italian Psychiatric Law Reform (Act 180). Part of this research took place at the University of Bologna, Italy, under the co-direction of the criminologist Massimo Pavarini, in order to understand how the country has been dealing with the compliance of the compulsory hospitalisation and how the Psychiatric Reform has advocated changes in the considered insane offender treatment. As a result, this thesis states that the union between the two fields of knowledge generates a third stream/speech, something different from what the jus sciences and the psi sciences produce alone. Since there is not a specific epistemology, practices aimed at these individuals do not have a limitation; there are no brakes, because there is not a well-defined science, but a merge between those two. And, as consequence, what eventually occurs is the legitimation of conducts that violate rights, acting against the considered insane offender, often in lethal ways. People crowded in legal mental institutions, differed by the other so-called "crazy people" just by the fact of having committed a crime. The law is applied to them not by imposition of medical science or legal science, but because the union of these two fields creates its own discourse, which is addressed to a person considered abnormal.

No description available.

Esta tese estuda o cumprimento das medidas de segurança no Brasil contemporâneo, a fim de compreender o impacto da Reforma Psiquiátrica e da Lei nacional 10.216/01 no campo dos considerados loucos criminosos. Para tanto, apresento a lógica periculosista voltada a esse grupo de sujeitos vulneráveis, examinando a maneira como ela se constitui e se mantém. Tendo como referencial teórico fundamentalmente as obras de Foucault e de Agamben, faço o mapeamento dos mecanismos atuantes no campo do considerado louco infrator que autorizam e legitimam as mais diversas violências contra os internos dos manicômios judiciários brasileiros. Esta tese, pois, centra-se nas seguintes questões: que mecanismos existem nos campos das práticas punitivas que anulam as conquistas realizadas no campo da saúde mental (Reforma Psiquiátrica)? Como as expressivas mudanças trazidas pela Lei 10.216/01 têm repercutido na forma de lidar com os loucos infratores? A partir da obra Os Anormais, de Foucault, discuto como ocorre a fusão entre as ciências jurídicas e psiquiátricas voltando-se a esse sujeito que não é nem considerado propriamente doente nem propriamente criminoso, mas um anormal. Para realizar tal objetivo, foram analisados materiais como: entrevista com Ernesto Venturini, anotações realizadas após visitas ao IPFMC de Porto Alegre, censo 2011 sobre hospitais psiquiátricos judiciários no país, Dados do Departamento Penitenciário Nacional (DEPEN), Parecer sobre Medidas de Segurança e Hospitais de Custódia e Tratamento Psiquiátrico sob a Perspectiva da Lei 10.216/01, elaborado pela Procuradoria Federal dos Direitos do Cidadão (PFDC) do Ministério Público Federal (MPF), Lei da Reforma Psiquiátrica brasileira (Lei 10.216/01) e Lei da Reforma Psiquiátrica italiana (Lei 180). Parte da investigação foi realizada na Universidade de Bologna, Itália, sob a coorientação do criminólogo Massimo Pavarini, para compreender de que maneira o país vem tratando o cumprimento das medidas de segurança e como a Reforma Psiquiátrica tem propugnado mudanças no tratamento do considerado louco infrator. Como resultado da tese aponto que a união entre ambos os campos do saber gera um terceiro discurso, algo distinto daquilo que sozinhas produzem as ciências jus e as ciências psi. Já que não há uma epistemologia própria, nas práticas voltadas a esses indivíduos não há uma limitação adequada, não há freios, porque também não há uma ciência definida, mas o entrelaçamento entre duas. E se é assim, o que ocorre é a legitimação de condutas violadoras de direitos que atuam sobre o considerado louco infrator, muitas vezes, de maneira inclusive letal. Pessoas amontoadas em manicômios judiciários, diferenciadas dos demais considerados loucos pelo fato de terem praticado um crime, e nas quais é possível incidir não porque a ciência médica ou jurídica simplesmente determine, mas porque a união desses saberes cria um discurso próprio voltado a um sujeito próprio chamado de anormal. / This thesis analyses the implementation of compulsory hospitalisation in Contemporary Brazil in order to understand the impact of the Psychiatric Reform and the National Law 10.216/01 on the considered insane offender field. Therefore, it presents the dangerous logic focusing on this group of vulnerable subjects, observing how it constitutes and maintains. Through the guidance of Foucault and Agamben’s works, it maps the mechanisms operating in the considered insane offender field, which authorize and legitimize the most diverse violence against inmates in Brazilian legal mental institutions. The central question of this thesis is, therefore, what are the existing mechanisms in the punitive practices field that nullify the achievements made in the mental health field (psychiatric reform)? How have the significant changes introduced by the Law 10.216/01 been reflecting in dealing with insane offenders? From Foucault’s Os Anormais book, I discuss how the merger between legal and psychiatric sciences occurs, focusing on this subject that is neither properly considered mentally ill nor strictly criminal, but an abnormal. To accomplish this objective, many resources were analysed, such as an interview with Ernesto Venturini; notes made after visits to IPFMC in Porto Alegre; the 2011 census on legal mental institutions in the country; data from the Departamento Penitenciário Nacional (DEPEN); researches on compulsory hospitalisation and Custody Hospitals and Psychiatric Treatment under the Law 10.216/01, carried out by the Federal Attorney for Citizens' Rights (PFDC) of the Federal Public Ministry (MPF), the Brazilian Psychiatric Law Reform (Law 10.216/01) and the Italian Psychiatric Law Reform (Act 180). Part of this research took place at the University of Bologna, Italy, under the co-direction of the criminologist Massimo Pavarini, in order to understand how the country has been dealing with the compliance of the compulsory hospitalisation and how the Psychiatric Reform has advocated changes in the considered insane offender treatment. As a result, this thesis states that the union between the two fields of knowledge generates a third stream/speech, something different from what the jus sciences and the psi sciences produce alone. Since there is not a specific epistemology, practices aimed at these individuals do not have a limitation; there are no brakes, because there is not a well-defined science, but a merge between those two. And, as consequence, what eventually occurs is the legitimation of conducts that violate rights, acting against the considered insane offender, often in lethal ways. People crowded in legal mental institutions, differed by the other so-called "crazy people" just by the fact of having committed a crime. The law is applied to them not by imposition of medical science or legal science, but because the union of these two fields creates its own discourse, which is addressed to a person considered abnormal.

En réponse aux contraintes économiques, au problème du vieillissement de la population et aussi à la volonté des patients de se faire soigner dans le milieu familial, l’Hospitalisation À Domicile (HAD) prend de plus en plus d’ampleur. Dans ce travail de recherche, nous nous intéressons aux établissements d’hospitalisation à domicile, parmi les différentes problématiques qui existent dans ce domaine, nous étudions le problème de routage et de planification des personnels.Nous développons tout d’abord un modèle de programmation linéaire en nombres entiers qui permet de formuler clairement les contraintes du problème.Nous présentons par la suite, une matheuristique permettant de résoudre le problème défini sur une journée de planification. Nous développons également une variante de notre matheuristique sur un horizon de 14 jours. Cette dernière prend en considération plusieurs contraintes en plus de celles considérées pour la planification sur une journée. Enfin, nous introduisons un problème de réoptimisation de routage et de la planification des personnels pour l’hospitalisation à domicile et présentons quelques approches de résolutions. Ces différentes méthodes combinent des heuristiques, la programmation dynamique et la programmation mathématique. / Home health care (HHC), i.e., visiting and nursing patients athome, is a growing sector in the medical care system. There fore, the optimal scheduling of the health care staffs arises. The objective of this problem consists in constructing routes and rosters for the staffs while optimizing costs. We propose an integer linear programming formulation (ILP) that clearly formulate the constraints of the problem. We present a matheuristic to solve the daily routing and rostering problem. We also develop a variant of our matheuristic defined for a period of 14 days. It takes into account several constraints in addition to those considered in the daily planning. Finally, we introduce the problem of reoptimizing the routing and rostering staffs and we give some ideas to solve this problem. These methods combine heuristic algorithms, dynamic programming and mathematical programming.

Philosophiae Doctor - PhD / The current study was, in part, prompted by the high case fatality rates for severe acute malnutrition in two district hospitals in the Eastern Cape Province in South Africa. These case fatality rates were being attributed to Human Immunodeficiency Virus infection rather than to mismanagement by nurses involved in the hospital management of SAM cases. There were also some anecdotes from clinicians in the same hospitals that, depending on the clinical stage of HIV infection, the World Health Organisation's ten-step protocol may show no effect. This left some uncertainties as to whether these guidelines are suitably designed for use during the management of HIV positive children who are severely malnourished and at different HIV clinical stages. This study sought to reinforce the design of a longstanding facility-based intervention originally developed to improve the management of severe acute malnutrition in two district hospitals in South Africa. The aim was to design an improved intervention which was implemented and evaluated to determine its potential effect on treatment outcomes, specifically in the context of high HIV comorbidity. The study also sought to provide the context for the effectiveness of this intervention, in terms of its implementation fidelity and associated moderating factors. Lastly, the study evaluated the sustainability of the intervention after it was discontinued. Methods The current study reports on the development, implementation and evaluation of an intervention to improve the management of severe acute malnutrition in two district hospitals in the Eastern Cape Province. A Sequential Explanatory Mixed Method Design was used. During the study, the effect of HIV infection, disease stage and other clinical characteristics on the survival of children with severe acute malnutrition was assessed. The relationship between the rate of weight gain and duration of hospitalisation based on HIV status and disease stage were also examined. The data were collected prospectively during the study using retrospective record review of a total of 450 severely malnourished children who were admitted and treated at the two facilities from 2009 to 2013.A pre-tested 76- item patient evaluation form was used to collect data on patient characteristics on admission, treatment processes and outcomes. Data analysis was performed using STATA13.0 and involved simple descriptive computation of quantitative variables as well as non-parametric tests to compare groups between and within hospitals. Kaplan-Meier curves and Cox proportional hazard modelling were used to analyse time to event data. The study also assessed the impact of the intervention at time intervals on outcomes of interest. The analysis focused on modelling and plotting monthly mortality statistics collected over a period of 69 months. This was done to detect related trend and level changes before, immediately (after the first two months) and after (following the two months) the removal of the intervention. Lastly ethnographic and focus group enquiries were used to explain the quantitative results. Two focus group discussions were held in each hospital with clinicians and the management staff. This was done at the end of phase three. The focus group data were analysed using the framework analysis approach.

Hund, bakterieller/ zytologischer Konjunktivalstatus, Konjunktivitis, Klinikaufenthalt