La planète Mars a connu une période où l'eau liquide était durablement stable. Outre les vestiges morphologiques d'une activité hydrologique en surface, l'interaction chimique de l'eau avec la croûte basaltique s'est traduite par la formation d'argiles et de sels hydratés en surface et en profondeur. Ces minéraux hydratés ont été détectés à la surface de Mars en 2004 grâce à l'instrument OMEGA, l'imageur hyperspectral infrarouge proche embarqué sur la sonde européenne Mars Express. Leur étude permet de reconstruire l'histoire de l'activité aqueuse sur Mars et de caractériser une période ancienne où l'environnement a pu être favorable à l'apparition d'une chimie pré-biotique. Ce travail de thèse s'intéresse aux environnements aqueux de Mars en couplant les données minéralogiques des imageurs hyperspectraux embarqués OMEGA/Mars Express et CRISM/Mars Reconnaissance Orbiter avec la morphologie. De nouveaux outils de traitement et d'analyse des données sont développés et ont permis la détection et la caractérisation spectrale de plus d'un millier de dépôts de minéraux hydratés sur Mars, fournissant une vue d'ensemble de l'altération. Celle-ci a eu lieu principalement dans la première partie du Noachien et a surtout formé des phyllosilicates ferro-magnésiens de la famille des vermiculites et smectites. Une importante diversité minérale est par ailleurs constatée avec une dizaine de familles minérales différentes, traçants des conditions géo-chimiques variées. Placés dans leur contexte géologique, certaines détections permettent de proposer l'existence passée d'un système hydrologique sur l'ensemble de la planète qui a donné naissance à un cycle des argiles similaire au cycle terrestre. Il apparait par ailleurs que les cratères d'impact sont le contexte privilégié des minéraux hydratés, mais le lien entre ces derniers et les processus d'impact demeure ambigu. La découverte d'un cycle des argiles est compatible avec l'hypothèse d'une planète potentiellement habitable au Noachien mais qui devra être vérifiée par l'exploration in-situ. / The planet Mars has experienced an era during which water was stable in its liquid state. In addition to morphological evidence for aqueous activity, the chemical interaction of water with the basaltic crust has led to the formation of hydrated clays and salts both on the surface and at depth. These hydrated minerals were first detected on the surface of Mars in 2004 with the OMEGA near infrared imaging spectrometer, onboard European probe Mars Express. Their study allows us to piece together the aqueous activity on Mars and to better understand an early era when the environment may have been conducive to prebiotic chemistry. This work focuses on the aqueous environments on Mars by coupling mineralogy data from the spaceborne imaging spectrometers OMEGA/Mars Express and CRISM/Mars Reconnaissance Orbiter to the surface morphology. The development of new data processing and analysis tools have led to the detection and spectral inquiry of over a thousand hydrated mineral exposures on Mars, thus providing a broad view of the aqueous alteration. The latter mostly took place during the Noachian era and formed primarily iron-magnesium bearing phyllosilicates of the vermiculite and smectite groups. In addition, great mineral diversity is found, implying varied geo-chemical formation conditions. Placed in their geological context, these detections show the likely existence of a past hydrological cycle on Mars which sustained a clay cycle similar to Earth's. It was also found that impact craters are the most common morphological context for these minerals, although the link between them remains unclear. The discovery of a clay cycle on Mars bodes well for the past habitability potential on Mars, but will need to be verified through in-situ exploration.

Master’s thesis discusses the design and implementation of network infrastructure for computer laboratory in Department of Communications. Thesis focuses on VLAN definitions and deployment of server virtualization, including network monitoring station.

Hiponimia ni uhusiano wa kifahiwa unaodhihirika baina ya leksimu ya jumla (hipanimu) na mahususi (hiponimu). Kama vile hipanimu mzazi hujumuisha hiponimu baba na mama. Uhusiano huu wa kihiponimia ulidhukuriwa na wanaisimu wa awali kuwa unahusisha leksimu nomino pekee. Hata hivyo, tafiti za hivi punde zinadhihirisha kuwa hiponimia huweza kudhihirika pia miongoni mwa kategoria za vivumishi, vielezi na vitenzi. Ingawa kuna midhihiriko ya hiponimia za vitenzi vya Kiswahili, wataalamu kadha wameelekea kushughulikia hiponimia za nomino na kutotilia maanani vitenzi. Hivyo basi, makala hii imechanganua uhusiano wa kihiponimia unaodhihirika miongoni mwa vitenzi teule vya Kiswahili. Katika kushughulikia suala hili, hipanimu vitenzi 24 kutoka kamusi za Kiswahili zimeteuli¬wa kimakusudi na hiponimu husika kutolewa. Nadharia ya Uchanganuzi Vijenzi kwa mujibu wa Katz na Fodor imezingatiwa katika uchanganuzi wa hiponimia hizi. Katika nadharia hii, sifa bainifu za hiponimu husika huonyeshwa kwa kutumia alama maalum za [+, -]. Data kuhusu hiponimia za vitenzi ilipekuliwa kutoka kamusi za Kiswahili kwa kuzingatia mwelekeo wa kiishara au kisintaksia kwa mujibu wa Hearst, na Snow na wenzake ili kuweza kutambua hipanimu na hiponimu husika katika sentensi. Hiponimia hizi zimechanganuliwa na kuwasilishwa kwa mtindo wa nadharia ya seti. / Hyponymy is a sense relation existing between general lexemes (hypernym) and the specific ones (hyponym). For instance, a hypernym parent includes hyponyms like father and mother. The hyponymy relation was regarded by earlier linguists that it could exist only amongst nouns. However, recent studies indicate that hyponymy can also be manifested in other categories such as adjectives, adverbs and verbs. Though there is hyponymy relation existing amongst Kiswahili verbs, various scho¬lars have tended to focus on nominal hyponymy and disregard verbal hyponymy. Therefore, this article has analyzed the hyponymy relation existing amongst selected Kiswahili verbs. In this regard, 24 verbal hypernyms from Kiswahili dictionaries were purposively sampled and their specific hyponyms indicated. Componential Analysis theory by Katz and Fodor has been used in the analysis of these hyponyms. The theory focuses on distinctive features of specific hyponyms that are normally shown by the use of specific signs [+, -]. The data on verbal hyponymy was observed from the Kiswahili dictionaries by the application of symbolic or syntactic approach propounded by Hearst, and Snow et al in order to identify the hypernyms and specific hyponyms in a sentence. These hyponymy relations are analyzed and presented using the set theory style.

The importance of balance between exploration and exploitation plays a crucial role while solving combinatorial optimization problems. This balance is reached by two general techniques: by using an appropriate problem solver and by setting its proper parameters. Both problems were widely studied in the past and the research process continues up until now. The latest studies in the field of automated machine learning propose merging both problems, solving them at design time, and later strengthening the results at runtime. To the best of our knowledge, the generalized approach for solving the parameter setting problem in heuristic solvers has not yet been proposed. Therefore, the concept of merging heuristic selection and parameter control have not been introduced. In this thesis, we propose an approach for generic parameter control in meta-heuristics by means of reinforcement learning (RL). Making a step further, we suggest a technique for merging the heuristic selection and parameter control problems and solving them at runtime using RL-based hyper-heuristic. The evaluation of the proposed parameter control technique on a symmetric traveling salesman problem (TSP) revealed its applicability by reaching the performance of tuned in online and used in isolation underlying meta-heuristic. Our approach provides the results on par with the best underlying heuristics with tuned parameters.:1 Introduction 1 1.1 Motivation 1 1.2 Research objective 2 1.3 Solution overview 2 2 Background and RelatedWork Analysis 3 2.1 Optimization Problems and their Solvers 3 2.2 Heuristic Solvers for Optimization Problems 9 2.3 Setting Algorithm Parameters 19 2.4 Combined Algorithm Selection and Hyper-Parameter Tuning Problem 27 2.5 Conclusion on Background and Related Work Analysis 28 3 Online Selection Hyper-Heuristic with Generic Parameter Control 31 3.1 Combined Parameter Control and Algorithm Selection Problem 31 3.2 Search Space Structure 32 3.3 Parameter Prediction Process 34 3.4 Low-Level Heuristics 35 3.5 Conclusion of Concept 36 4 Implementation Details 37 4.2 Search Space 40 4.3 Prediction Process 43 4.4 Low Level Heuristics 48 4.5 Conclusion 52 5 Evaluation 55 5.1 Optimization Problem 55 5.2 Environment Setup 56 5.3 Meta-heuristics Tuning 56 5.4 Concept Evaluation 60 5.5 Analysis of HH-PC Settings 74 5.6 Conclusion 79 6 Conclusion 81 7 FutureWork 83 7.1 Prediction Process 83 7.2 Search Space 84 7.3 Evaluations and Benchmarks 84 Bibliography 87 A Evaluation Results 99 A.1 Results in Figures 99 A.2 Results in numbers 105

La evaluación de daños de inundaciones, sismos, huracanes entre otros fenómenos en el mundo son analizados con metodologías como las curvas de vulnerabilidad. En el Perú, los desastres originados por flujos hiperconcentrados aún son alarmantes debido al cambio climático e incremento de la intensidad de fenómenos como el niño costero (FENC). Por ello, la presente tesis desarrolla curvas de vulnerabilidad para viviendas de albañilería confinada de 1 y 2 pisos de la Urb. San Idelfonso en Ica, relacionando la variable: profundidad de flujo, asociado al evento producido por las lluvias intensas en la cabecera de la quebrada Cansas que desencadenó el FENC 2017, y el porcentaje de daño: basado en la metodología del Cuerpo de Ingenieros de Estados Unidos (USACE), cuya formulación es la relación entre el valor de reparación entre valor total de la vivienda. Los importes monetarios y partidas de la vivienda fueron obtenidos de la resolución ministerial RM 415-2017-VIVIENDA. El proceso consiste en el modelamiento hidrológico en HEC-HMS, hidráulico en FLO-2D, estimación del porcentaje de daño y generación de las curvas de vulnerabilidad. Se han contrastado las curvas de vulnerabilidad para flujos hiperconcentrados (lodos) con investigaciones de curvas generadas para inundaciones y flujo de detritos. Los resultados demuestran que el evento del 2017 tuvo una afectación económica de al menos 1.3 millones de soles. Finalmente se generaron mapas de daños para los TR de 10, 20, 50, 100, 150 y 200 años y se calcularon los importes monetarios de reparación por vivienda en la Urb. San Idelfonso. / The damage assessment from floods, earthquakes, hurricanes among other phenomena in the world are analyzed with methodologies such as vulnerability curves. In Peru, disasters caused by hyper-concentrated flows (muds) are alarming due climate change and the increased intensity of phenomena such as “El Niño Costero (FENC)”. Therefore, the present thesis develops vulnerability curves for 1 and 2 story confined masonry buildings of the Urb. San Idelfonso – Ica, relating the variable: flow depth, associated with the event produced by the heavy rains at the head of “Quebrada Cansas” caused by FENC 2017 and the percentage damage: based on the methodology of the United States Corps of Engineers (USACE), whose formulation is the repair value between total building value. The monetary amounts and items of the building are obtained from the RM 415-2017-VIVIENDA. The process consists of hydrological modeling in HEC-HMS, hydraulic modeling in FLO-2D, estimation of the percentage of damage and generation of vulnerability curves. Vulnerability curves for hyper-concentrated flows (muds) have been contrasted with investigations of curves generated for floods and debris flow. The results show that the 2017 event had an economic impact of at least 1.3 million soles. Finally, damage maps were generated for the TR of 10, 20, 50, 100, 150 and 200 years and the monetary amounts for building repair in Urb. San Idelfonso were calculated. / Tesis

Mass spectrometry has been used extensively in recent years as a valuable tool in the study of proteomics. However, the data thus produced exhibits hyper-dimensionality. Reducing the dimensionality of the data often requires the imposition of many assumptions which can be harmful to subsequent analysis. The IP algorithm is a dimension reduction algorithm, similar in purpose to latent variable analysis. It is based on the principle of maximum entropy and therefore imposes a minimum number of assumptions on the data. Partial Least Squares (PLS) is an algorithm commonly used with proteomics data from mass spectrometry in order to reduce the dimension of the data. The IP algorithm and a PLS algorithm were applied to proteomics data from mass spectrometry to reduce the dimension of the data. The data came from three groups of patients, those with no tumors, malignant or benign tumors. Reduced data sets were produced from the IP algorithm and the PLS algorithm. Logistic regression models were constructed using predictor variables extracted from these data sets. The response was threefold and indicated which tumor classifications each patient belonged. Misclassification rates were determined for the IP algorithm and the PLS algorithm. The rates correct classification associated with the IP algorithm were equal or better than those rates associated with the PLS algorithm.

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This study is based on a qualitative document analysis aimed at investigating stigma related to mental illness. Mental illness can affect individuals at different levels. This study has been conducted by a qualitative thematic analysis of virtual documents to understand how men and women understand and get affected by the stigma of mental illness. And the various outcomes that the diagnosis of mental illness entails for both men and women. The virtual documents that the study has used are personal stories from Mind. Mind is a website where people who have suffered or are suffering from mental illness write stories about their mental illness. The results of the study showed that most men and women with mental illness suffer from stigma, however there may be differences between how men and women relate to mental illness. Stigmatization and shame about mental illness can be contributing factors to the individual's propensity for help. According to the study, it turned out that there are different factors that can dictate how men and women relate to their mental state. / Denna studie är baserad på en kvalitativ fallstudie med syfte till att undersöka stigma relaterat psykisk ohälsa. Psykisk ohälsa kan påverka individer på olika nivåer. Denna studie har genomfört en kvalitativ tematisk analys av virtuella dokument där syftet är att förstå hur män och kvinnor uppfattar och påverkas av stigmatiseringen kring psykisk ohälsa, samt de olika utfallen som diagnosen psykisk ohälsa medför för män och kvinnor. De virtuella dokument som studien har använt sig av är personliga berättelser från Mind. Mind är en webbplats där personer som drabbats av eller lider av psykisk ohälsa skriver berättelser om sin psykiska ohälsa. Studiens resultat visade på de flesta män och kvinnor med psykisk ohälsa drabbas av stigmatisering, däremot kan det skilja sig mellan hur män och kvinnor förhåller sig till psykisk ohälsa. Stigmatisering och skam kring psykisk ohälsa kan vara bidragande faktorer till individens benägenhet till avsikter om hjälp. Enligt studien visade det sig att det finns olika faktorer som kan diktera hur män och kvinnor förhåller sig till det psykiska tillståndet.

Aberrant DNA methylation in stem cells is a hallmark of aging and tumor development. Recently, we have suggested that promoter DNA hyper-methylation originates in DNA repair and that even successful DNA repair might confer this kind of epigenetic long-term change. Here, we ask for interrelations between promoter DNA methylation and histone modification changes observed in the intestine weeks after irradiation and/or following Msh2 loss. We focus on H3K4me3 recruitment to the promoter of H3K27me3 target genes. By RNA- and histone ChIP-sequencing, we demonstrate that this recruitment occurs without changes of the average gene transcription and does not involve H3K9me3. Applying a mathematical model of epigenetic regulation of transcription, we show that the recruitment can be explained by stronger DNA binding of H3K4me3 and H3K27me3 histone methyl-transferases as a consequence of lower DNA methylation. This scenario implicates stable transcription despite of H3K4me3 recruitment, in agreement with our RNA-seq data. Following several kinds of stress, including moderate irradiation, stress-sensitive intestinal stem cell (ISCs) are known to become replaced by more resistant populations. Our simulation results suggest that the stress-resistant ISCs are largely protected against promoter hyper-methylation of H3K27me3 target genes.

This dissertation concerns the development of the MicroWave Radiometer (MWR) brightness temperature (Tb) algorithm and the associated algorithm validation using on-orbit MWR Tb measurements. This research is sponsored by the NASA Earth Sciences Aquarius Mission, a joint international science mission, between NASA and the Argentine Space Agency (Comision Nacional de Actividades Espaciales, CONAE). The MWR is a CONAE developed passive microwave instrument operating at 23.8 GHz (K-band) H-pol and 36.5 GHz (Ka-band) H- and V-pol designed to complement the Aquarius L-band radiometer/scatterometer, which is the prime sensor for measuring sea surface salinity (SSS). MWR measures the Earth's brightness temperature and retrieves simultaneous, spatially collocated, environmental measurements (surface wind speed, rain rate, water vapor, and sea ice concentration) to assist in the measurement of SSS. This dissertation research addressed several areas including development of: 1) a signal processing procedure for determining and correcting radiometer system non-linearity; 2) an empirical method to retrieve switch matrix loss coefficients during thermal-vacuum (T/V) radiometric calibration test; and 3) an antenna pattern correction (APC) algorithm using Inter-satellite radiometric cross-calibration of MWR with the WindSat satellite radiometer. The validation of the MWR counts-to-Tb algorithm was performed using two years of on-orbit data, which included special deep space calibration measurements and routine clear sky ocean/land measurements.