Orientador: Luis Fernando Barbisan / Resumo: O câncer de mama apresenta história natural diversa, histologia complexa e com incidência crescente nas últimas décadas. Atualmente, existem poucos tratamentos para o câncer de mama hormônio-dependente e as drogas comumente utilizadas estão intimamente associadas a graves efeitos colaterais que limitam sua utilização. A imunoterapia apresenta-se como uma vertente para o tratamento do câncer e cresce cada vez mais o número de pesquisas voltadas ao papel de receptores toll-like no processo de carcinogênese. O P-MAPA é considerado um imunomodulador e através de estudos experimentais e ensaios clínicos, este composto tem demonstrado exercer atividade antiviral e antitumoral, aumentando a expressão de citocinas, ativando linfócitos e receptores toll-like. Assim, os objetivos do presente estudo foram caracterizar e comparar os efeitos histopatológicos e moleculares da imunoterapia com P-MAPA associada ao Tamoxifeno no tratamento do câncer de mama induzido quimicamente em ratas Sprague-Dawley (SD). Para o desenvolvimento deste trabalho, fêmeas SD foram divididas em sete grupos experimentais: os grupos 1-4 receberam dose única do carcinógeno 7,12- dimetil-benzoantraceno (DMBA) (80 mg/kg, i.g) durante a primeira semana do experimento, enquanto os grupos 5-7 receberam dose única do veículo da DMBA. A seguir, grupos 2 e 5 receberam doses do P-MAPA (5,0 mg/kg, 3x/semana, i.p) e do veículo do Tamoxifeno (5x/semana). Os grupos 3 e 6 receberam doses do P-MAPA e do Tamoxifeno (100ug/kg, 5x/s... (Resumo completo, clicar acesso eletrônico abaixo) / Doutor

[pt] Diante das intervenções humanas relacionadas aos barramentos de rios para inúmeros fins (controle hídrico, produção de energia, entre outras) verifica-se os riscos associados às populações que vivem a jusante destas áreas. O entendimento das possíveis consequências ambientais deste tipo de ocorrência promove a emergência de se avaliar as áreas impactadas, permitindo-se desta maneira a promoção de ações (estruturais ou estruturantes) que visem minimizar o efeito no caso de acidentes. Este estudo visa avaliar e correlacionar os impactos associados às inundações provenientes das rupturas dos barramentos de rios através de um estudo de caso (Reservatório de Santa Branca/SP) a partir de dados obtidos por modelagem hidrológica e de técnicas de geoprocessamento. Como resultado, torna-se possível avaliar não apenas as áreas impactadas pelo rompimento do barramento estudado, mas também avaliar as áreas que apresentariam maiores velocidades (acarretando riscos materiais à população) e também verificar as porções territoriais mais passíveis de sofrerem algum tipo de intervenção pública. As variáveis estudadas, com o intuito de minimizar os impactos, foram: arborização, pavimentação e boca de lobo. Estas, foram comparadas par a par através do método de tomada de decisões AHP, e concluiu-se que a variável que mais ajuda a minimizar o impacto é a arborização. Devido a modelagem hidrológica foi possível encontrar uma vazão de pico de 77.8855,045 metros cúbicos/s para um tempo de ruptura de 2,5h e verificar que a mancha de inundação abrange as seguintes cidades a jusante da barragem: Santa Branca, Guararema e Jacareí, atingindo o total aproximado de 32.590 habitantes. / [en] Floods have always been a major hydrological issue. Its susceptibility is caused by many factors, such as soil sealing, deforestation, disordered densification, climatic variations, among others. Currently Floods have been occurring on a large scale around the world, Brazil included, bringing high social and economic damage to the affected cities. Even with a low probability of ocurring, its devastating effects has ignited the interest of public agenciesresponsible for security and civil protection to study and plan solutions to mitigate its effects. Knowing how to cope with floods by mitigating their adverse impacts is a measure that should be adopted by civil society and public agencies through interlinked urban and environmental planning.

O estudo buscou identificar as relações entre letramento/alfabetização e gênero, raça e condições de ocupação no Brasil e diferentes Unidades da Federação, tendo como base empírica os microdados da Pesquisa Nacional por Amostras de Domicílios (PNAD), realizada pelo Instituto Brasileiro de Geografia e Estatística (IBGE) em 2002. O modelo de análise foi elaborado com base nos níveis de letramento propostos por Ferraro (2002) a partir da variável “anos de estudo concluídos com êxito”, incluindo-se o nível 0, que corresponde a quem se declarou sem instrução ou com menos de um ano de estudo. Verificaram-se grandes desigualdades entre as regiões e as Unidades da Federação em termos de sua distribuição pelos diferentes níveis de letramento. Apenas o Distrito Federal e os estados de São Paulo e Rio de Janeiro, da Região Sudeste, e Paraná e Rio Grande do Sul, da Região sul, apresentaram, no nível mais alto de letramento, taxas superiores à do Brasil como um todo. No nível mais alto de letramento (Nível 4 - 11 anos ou mais anos de estudo), as mulheres superam os homens em todos os grupos de idade mais jovens, de 10 a 14 anos até 50 a 54 anos. Apenas nos grupos de idade mais avançada, de 55 ou mais anos, os homens continuam a superar a mulheres nesse nível de letramento Isto indica que, a partir de meados do século XX, foi verificando-se uma inversão histórica do fenômeno da desigualdade em educação, com vantagem, agora, para as mulheres no que se refere a níveis de letramento. A intersecção de raça e gênero revelou que essas duas dimensões se somam e se sobrepõem, mas mantendo cada uma dessas duas dimensões a sua especificidade. Com efeito, em todas as idades, independentemente de qual gênero leve vantagem em termos de letramento, os homens brancos sempre superam os homens negros, da mesma forma que as mulheres brancas sempre levam vantagem em relação às mulheres negras. As variáveis gênero e raça contribuíram também muito para o diagnóstico das desigualdades no estudo do letramento quando analisadas em relação à condição de ocupação das pessoas.

Diploma thesis was focused on data yield map processing, their interpretation and analysis of relations with another spatial data. Aims of the work were identification error values, statistical process yield data and with help statistical methods evaluate correlation between yield map and another spatial data. Methods were based on gathering yield data with combine harvester during two years in corn and malting barley in conditions of farm. With using GIS and predefined tolls were removed error values from yield data and created yield maps. Subsequently, yield maps were analyzed with vegetation index NDVI, digital elevation model (DEM), sensor measurements of soil electrical conductivity and historical yield maps. In results was achieved removing from 11,3 to 13,8 % yield points in average, increasing of average yield from 3,6 to 4,7 % and decreasing of variation coefficient between 7,0 and 8,6 % with comparing original yield data and depending on planting crops during data yield processing. In case of evaluation of relations between yield map and NDVI obtained from satellite remote sensing was achieved moderately correlation by corn (r = 0,44) and malting barley (r = 0,65) in average depending on times of imaging and vegetative phase of the crop. In the evaluation relations between yield maps and DEM and slope was achieved weak and very weak direct and indirect correlation. Likewise, by soil electrical conductivity and yield was achieved very weak to negligible correlation. Conversely, the highest correlation was achieved between yield map and historical yield map (r = 0,63) in average. Obtained information serve as starting point for making agronomy decisions in conditions of particular farm in case of replacement of creating yield maps by prediction of yield based on another spatial data.

This diploma thesis deals with the implementation of selected simultaneous locali-zation and mapping (SLAM) algorithm for mobile robot and testing of this algo-rithm. In theoretical part there is a research that describes various existing SLAM algorithms. One of these algorithms is selected for the implementation based on the selected criteria at the end of the research. Practical part of the thesis deals with the implementation of selected SLAM algorithm in particular programming language and with its testing on real data. Computer simulation in which model of the robot travels through the model of Q Building of Mendel University in Brno is created for the purpose of testing.

The aim of this thesis is the draft of risk management model applicable in construction companies providing the service "turnkey". The first part focuses on project management and risk management in general. The second part is the whole issue applied to construction companies providing the service "turnkey". First, the identification of bearing assets of businesses is performed, and their risks are then defined. Load-bearing assets and their risks are sought in the internal and external environment using PESTE analysis and Porter's model of competitive forces. Afterwards, the most serious-risks are selected. Selected risks are supplied with the amount of potential damage and the probability of its occurrence is determined. The significance of selected risk is captured in the risk matrix. The results of the thesis are proposals for strategies "4 T" Risk Management for management of companies.

This master thesis deals with creating a concept of performance evaluation model in scope of Balanced Scorecard methodology for selected business unit. In theoretical part of this thesis are described basic principles of this method, including its perspectives and general rules of the implementation process. In practical part was performed a strategic analysis of business unit. On its basis is compiled business strategy for selected time period and also specific key performance indicators for evaluation of reaching strategic goals.

The purpose of this thesis is design a collection of action, which will speed up distributional ways between regional grocery producers and schools cafeterias in the district of Jindrichuv Hradec and at the same time supports higher regional, fresh, seasonal and ecologist products in schools cafeterias via the website Regional Agrarian Chamber of the South Bohemian Region "Map of products" (interactive regional map of suppliers of foods and different schools cafeterias at www.produktova-mapa.cz). Not such a long distributional truck trips are much healthier for the milieu. Better quality of foods have major positive impact on health of children and teenagers and their eating habits. Regional products distribution is great way to independency. Study of documents, questionnaires of schools cafeteria employees and regional food producers, consultations with people they are interested were bedding for SWOT analysis potential "Map of products" and creating a lists of regional food producers, whom are or could by distributers for schools cafeterias. From study emerges that "Map of products" is very beneficial in shortening ways between distributers and different cafeterias in South Bohemia region. Strengths and opportunities already today outweigh the weaknesses and threats. The main opportunities emergent from results are 92% of certain school cafeterias are serving at least one time a week food from the same region. 70% certain regional producers are interested in supplying these cafeterias. There is a 1 650 000 students eating at the cafeterias. If following suggested strategies and steps we can prevent form weak parts of project and turn it in to a solid strong successful proceeding. For that we have build a list of accommodating regional producers for school cafeterias from district Jindrichuv Hradec. And also "Map of products" can be used as an example in improving in regional food production and also in other areas of the Czech Republic.

This thesis is devoted to clarifying the issue of atlas production offer and its availability within the scope of the Czech republic. An atlas is a collection of maps interconnected via their purpose, theme, scale coefficient or scale coefficient set, generalization and other system aspects. These are conceptually processed cartographically and polygraphicaly as a unified work. The opening part explains the characteristics of atlas production including the historical development of cartography which is related to this issue. The following part depicts the division of atlases according the individual typology. Another thing elucidated here is which atlases are available in the Czech republic. Only selected atlases are mentioned in this section. The main section of this thesis focuses on the specific cartographic representation and cartographic presentation at a given area. It is a modern method of presentation alternative and utilization of a cartographic digital production what is engaged here.

The subject of thesis Process management and its use in optimization is drafting process change in real company and its subsequent implementation. The work focuses on the steps important to the change process, their explanation and subsequent use in practical part. Thesis is divided into two main parts. First part is a theoretical background of the process management and a development of this sector, explanation of key concepts closely related with process management to a description of a specific methods, which play a role in the process of company management.Next part is a practical part where most of the theoretical background was used. Practical work itself is a real-world example of the banking environment, where was actually implemented. Because of a limited possibility to publish the practical part, I do not mention a particular company and the data used for the preparation example are type data - these are not real data. However, the implementation of process changes was set this way and works now, and since it was the optimization, it is therefore expected that this change will bring its savings in the future. Since the implementation of the changes has already occurred, even this assumption was fulfilled and set change of process still generates its savings.