This work focuses on importance of pension motive for havin children in developed countries. It starts with discussion of conditions, under which old age security hypothesis is likely to hold. It continues with overview of demographic trends in selected developed countries and stresses the negative impact of long term fertility decline on pension systems sustainability and performance. In the next part of this thesis we use cluster analysis to compare pension systems in developed countries and the way developed countries deal with lack of human capital. Special attention is paid to comparison of Scandinavian social welfare state model with Southern European welfare state model and with group of three Asian Tigers. Keywords: fertility, pension systems, family economics

Die vorliegende Arbeit wurde im Rahmen einer kooperativen Promotion zwischen der TU Dresden und der Hochschule Mittweida angefertigt. In dieser werden neuartige, computerorientierte Ansätze für die Analyse von Membranproteinen vorgestellt. Membranproteine sind von essentieller Bedeutung für eine Vielzahl biologischer Prozesse innerhalb eines Organismus und stellen wichtige Zielmoleküle für eine breite Palette von Pharmazeutika dar. Ihre Sequenzen liefern wertvolle und teilweise noch nicht entschlüsselte Informationen über die dreidimensionale Struktur und funktionale Eigenschaften. Innerhalb der Proteomik und Genomik stellen Analysen an Membranproteinstrukturen einen wichtigen Teil für das Verständnis komplexer biologischer Prozesse dar. Im Zuge von Untersuchungen an Membranproteinen konnte eine Vielzahl kurzer wiederkehrender Muster, sogenannte Motive, in den Sequenzen von Membranproteinen beobachtet werden. Diese Motive unterstützen das Verständnis, wie sich Membranproteine in der Zellmembran falten. Im Fokus dieser Arbeit stehen derartige Sequenzmotive. Innerhalb von drei Projekten bilden ausschließlich sequenzmotivbasierte Ansätze die Grundlage für nähere Untersuchungen an Membranproteinstrukturen. Letztendlich liefern die in dieser Arbeit postulierten Methoden wertvolle Erkenntnisse über die strukturelle und funktionelle Rolle von Sequenzmotiven, auf deren Grundlage dazu beigetragen wird, den komplexen Aufbau von Membranproteinen besser verstehen zu können. Generell wird die Zusammenführung proteomischer und mutagener Informationen intensiviert. Nicht zuletzt wird dazu beigetragen, die in dieser Arbeit zusammengetragenen Ergebnisse, für die Planung von in vitro Experimenten sowie weiterführenden Arbeiten auf dem Gebiet der Membranproteinanalyse, der Wissenschaft zur Verfügung zu stellen. / The present work was written as part of a cooperative doctorate between the TU Dresden and the University of Applied Sciences Mittweida. In the doctoral thesis, novel, computer-oriented approaches for the analysis of membrane proteins are presented. Membrane proteins are essential for many cellular processes and are important targets for a wide range of pharmaceuticals. Their sequences provide valuable and partly not yet decoded information about their three-dimensional structure and functional characteristics. The analysis of membrane proteins is an important part for the understanding of complex biological processes in the context of proteomics and genomics. Research of membrane proteins revealed a large number of short, distinct sequence motifs. The motifs found so far support the understanding of the folded protein in the Membrane environment. In this dissertation, in three different approaches it is shown how the output of sequence motif-based methods can support the understanding of structural and functional properties of membrane proteins. In general, the junction of proteomic and mutagenic information is intensified. Last but not least, the results of this work are made available for the planning of in vitro experiments as well as for further works in the field of membrane Protein analysis.

Cells require adenosine triphosphate (ATP) to drive the myriad processes associated with growth, replication, and homeostasis. Eukaryotic cells rely on mitochondria to produce the vast majority of their ATP. Mitochondria consist of a relatively smooth outer mitochondrial membrane (OMM) and a highly complex inner mitochondrial membrane (IMM), containing numerous invaginations, called cristae, which house the molecular machinery of oxidative phosphorylation (OXPHOS). Although mitochondrial form and function are intimately connected, limitations in the resolution of live-cell imaging have hindered the ability to directly visualize the relationship between the architecture of the IMM and its associated bioenergetic properties. Using advanced imaging technologies, including Airyscan, stimulated emission depletion (STED), and structured illumination microscopy (SIM), we developed an approach to image the IMM in living cells. Staining mitochondria with various ΔΨm-dependent dyes, we found that the fluorescence pattern along the IMM was heterogeneous, with cristae possessing a significantly greater fluorescence intensity than the contiguous inner boundary membrane (IBM). Applying the Nernst equation, we determined that the ΔΨm of cristae is approximately 12 mV stronger than that of IBM, indicating that the electrochemical gradient that drives ATP synthesis is compartmentalized in cristae membranes. Notably, deletion of key components of the mitochondrial contact site and cristae organizing system (MICOS), as well as OPA1, which regulate crista junctions (CJs), decreased ΔΨm heterogeneity. Complementing our super-resolution imaging of cristae in living cells, we also developed a machine-learning protocol to quantify IMM architecture. Tracking real-time changes in cristae density, size, and shape, we determined that cristae dynamically remodel on a scale of seconds. Furthermore, we found that cristae move away from sites of mitochondrial fission, and, prior to mitochondrial fusion, the IMM forms finger-like protrusions bridging the membranes of the fusing organelles. Lastly, we investigated the role of the motor adaptor protein, Milton1/TRAK1, in mitochondrial dynamics. Patient-derived Milton1-null fibroblasts not only had impaired mitochondrial motility but exhibited fragmentation corresponding to a roughly 40% decrease in mitochondrial aspect ratio and a 17% increase in circularity, associated with increased DRP1 activity. Conversely, we found that overexpression of Milton1 led to mitochondrial hyperfusion, decreased DRP1 activity, and aberrant clustering of mtDNA. Overall, our studies directly demonstrate that maintaining mitochondrial architecture is essential for preserving the functionality of mitochondria, the hubs of eukaryotic metabolism.

This master thesis in Economic History explores the human capital transfer embodied in Swedish emigrants migrating to North America, during the period 1860-1923. Previous research on this topic has mainly focused on the second and third generation of Swedish-Americans, but the focus of this paper is on the first generation. The results indicates a high level of human capital transfer for the whole period, but increasing sharply after 1900. The thesis evaluates two different models for signaling human capital transfer, one based on social mobility, and the other on emigration motive. By considering migration motive it has been possible to use source material collected at a single point in time, before emigration taking place, but still knowing that these migrants were moving. The concept of informal human capital extends the analysis and makes it possible to use more source material compared to a situation with only formal human capital.

The dual motive model posits that self-control is the prioritization of distal motives over proximal motives when the two compete. A logical extension of this view is that any factor that increases the incentive value of a distal motive or decreases the incentive value of a proximal motive will make self-control more likely. Here it is proposed that time perspective, or an individual's tendency to attend to thoughts of the past, present, or future, is one factor that influences the incentive value of competing motives. Three studies were conducted to show that time perspective influences the incentive value of competing motives, and thus influences self-control. Study 1 probes correlations and indirect effects between time perspective, incentive value, and self-control. Study 2 replicates and extends study 1 by examining additional dimensions of the future time perspective. Study 3 shows that manipulating time perspective produces changes in self-control, establishing causality. The results suggest that time perspective influences the incentive value of individuals' motives and thus self-control. The results also add support to the dual motive model of self-control, since only the dual motive model predicted these relationships.

京都大学 / 新制・課程博士 / 博士(理学) / 甲第23048号 / 理博第4725号 / 新制||理||1677(附属図書館) / 京都大学大学院理学研究科生物科学専攻 / (主査)教授 鹿内 利治, 准教授 竹中 瑞樹, 教授 長谷 あきら / 学位規則第4条第1項該当 / Doctor of Science / Kyoto University / DFAM

Indiana University-Purdue University Indianapolis (IUPUI) / The purpose of this study was to examine the relationships among motives for health-related YouTube use, cognitive involvement with health information on YouTube, post-exposure online activity, and sense of empowerment regarding health and health care. As a result of the analysis of data from 263 participants, social utility, convenient information-seeking, habit-passing time, and exciting entertainment motives were identified as four motives for health-related YouTube use. Social utility and convenient information-seeking motives were positively related to cognitive involvement and cognitive involvement was positively related to perceived control. Social utility motive was negatively related to perceived competence, whereas convenient information-seeking motive was positively related to perceived competence. Habit-passing time motive was negatively related to goal internalization, whereas convenient information-seeking and exciting entertainment motives were positively related to goal internalization. The findings from this study imply that YouTube could be a useful health communication media for health professionals and organizations to use for empowering users in coping with health-related concerns.

Chapter 1: “Role of cyclic electron transport around photosystem I in the regulation of proton motive force” is based on the following paper. Caijuan Wang, Hiroshi Yamamoto, Toshiharu Shikanai, Role of cyclic electron transport around photosystem I in regulating proton motive force, Biochimica et Biophysica Acta (BBA) - Bioenergetics, Volume 1847, Issue 9, September 2015, Pages 931-938, ISSN 0005-2728, http://dx.doi.org/10.1016/j.bbabio.2014.11.013.(http://www.sciencedirect.com/science/article/pii/S0005272814006586) / 京都大学 / 0048 / 新制・課程博士 / 博士(理学) / 甲第19535号 / 理博第4195号 / 新制||理||1602(附属図書館) / 32571 / 京都大学大学院理学研究科生物科学専攻 / (主査)教授 鹿内 利治, 教授 西村 いくこ, 教授 長谷 あきら / 学位規則第4条第1項該当 / Doctor of Science / Kyoto University / DGAM

In dieser Seminararbeit skizziere ich den widersprüchlichen und ambigen Weg Hans Scholls beginnend mit seiner Jugend, dem Eintritt in die HJ bis zur inneren Abkehr und der Gründung der Weißen Rose. Dabei versuche ich nachzuweisen, dass die Entfremdung von der HJ durch die Struktur und innere Ideologie des Nationalsozialismus zustande kommt.:Für Führer und Vaterland - gegen Führer und Vaterland? Hans Scholls Weg von der HJ in den Widerstand. 1. Einleitung 3 2. Kurzbiographie Hans Scholl 4 3. Hans Scholls Weg in die HJ 5 4. Hans Scholl und die Entfremdung vom Nationalsozialismus 10 5. Konklusion 14 6. Literaturverzeichnis 16 Selbstständigkeitserklärung 17

本研究は差別や偏見についての日常会話に出てくる動機の語彙をアナライズし、本来のレイシズム研究にあるギャップ（エブリデイレイシズム）を特定して埋めることを目的としています。CWミルズの動機の語彙とポストコロニアル・スタディーズの濫喩の概念を利用し、伊賀上野市民が町での反外国人差別について話し合う時の発言とアメリカのネット社会で起こるウェブ論争を調査対象にしている。 / This project aims to identify and fill gaps in the current literature on conversational manifestations of discrimination, bias, and racism. Utilizing C. Wright Mills's concept of vocabulary of motive bolstered by the postcolonial concept of catachresis, the paper examines utterances by which individuals in society navigate talk surrounding exclusionism, discrimination, and racism. Other researchers have identified this hole in the literature, but their work focuses more on narratives driven by media and political figures. Subjects here are citizens of Iga Ueno, Japan, as they discuss anti- foreign discrimination in their town and American netizens commenting on the Colin Kaepernick controversy. / 博士(現代アジア研究) / Doctor of Philosophy in Contemporary Asian Studies / 同志社大学 / Doshisha University