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The Global ETD Search service is a free service for researchers
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Networked Digital Library of Theses and Dissertations.
Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
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Showing 121 to 130 of 268 (0.013 seconds)| 121 |
Structure and Dynamics of AcrA, a Periplasmic Component of a Multidrug Efflux PumpIp, Hermia 18 February 2010 (has links)
AcrA is the periplasmic component of an efflux system AcrA-AcrB-TolC, which can expel different classes of antibiotics. AcrB is the inner membrane (IM) pump that utilizes proton-motive force for the active transport, TolC is the outer membrane (OM) channel, and AcrA coordinates the actions of AcrB and TolC, so that substrates are expelled across the two membranes, bypassing the periplasm. It has been proposed that AcrA either provides a static seamless link between AcrB and TolC, or acts like its analogous viral membrane fusion protein (MFP) and actively brings the IM and OM closer for substrate transfer. To better understand the role of AcrA in the efflux mechanism, site-directed spin labeling (SDSL)/EPR (electron paramagnetic resonance) spectroscopy is used to investigate the structure and dynamics of AcrA in solution. My results demonstrated that AcrA is a dynamic protein that undergoes pH-dependent and reversible conformational changes. AcrA contains an interrupted alpha-helical, coiled-coil domain flanked by a pair of beta-stranded lipoyl motifs, and my SDSL/EPR analysis revealed that the pH-induced conformation change mainly involves the coiled-coil and the lipoyl domains. In addition, I found that each AcrA monomer folds into an intra-molecular hairpin and AcrA monomers oligomerize with their coiled-coil hairpins aligned in parallel. Unlike the pH-induced conformational rearrangement of a viral MFP, change in pH alters both intra- and inter-molecular interaction along the coiled-coil of AcrA without rearranging the hairpin fold. The organization of AcrA protomers and its pH-induced conformational switching are, however, congruent with the TolC coiled-coil hairpins in the iris-like opening of the TolC channel. Together, my studies suggest that rather than being a passive structural linkage between AcrB and TolC, AcrA plays an active role mediating the drug efflux. The reported AcrA dynamics provides new insights into the AcrA-TolC interactions for the channel opening during the efflux process.
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Structure and Dynamics of AcrA, a Periplasmic Component of a Multidrug Efflux PumpIp, Hermia 18 February 2010 (has links)
AcrA is the periplasmic component of an efflux system AcrA-AcrB-TolC, which can expel different classes of antibiotics. AcrB is the inner membrane (IM) pump that utilizes proton-motive force for the active transport, TolC is the outer membrane (OM) channel, and AcrA coordinates the actions of AcrB and TolC, so that substrates are expelled across the two membranes, bypassing the periplasm. It has been proposed that AcrA either provides a static seamless link between AcrB and TolC, or acts like its analogous viral membrane fusion protein (MFP) and actively brings the IM and OM closer for substrate transfer. To better understand the role of AcrA in the efflux mechanism, site-directed spin labeling (SDSL)/EPR (electron paramagnetic resonance) spectroscopy is used to investigate the structure and dynamics of AcrA in solution. My results demonstrated that AcrA is a dynamic protein that undergoes pH-dependent and reversible conformational changes. AcrA contains an interrupted alpha-helical, coiled-coil domain flanked by a pair of beta-stranded lipoyl motifs, and my SDSL/EPR analysis revealed that the pH-induced conformation change mainly involves the coiled-coil and the lipoyl domains. In addition, I found that each AcrA monomer folds into an intra-molecular hairpin and AcrA monomers oligomerize with their coiled-coil hairpins aligned in parallel. Unlike the pH-induced conformational rearrangement of a viral MFP, change in pH alters both intra- and inter-molecular interaction along the coiled-coil of AcrA without rearranging the hairpin fold. The organization of AcrA protomers and its pH-induced conformational switching are, however, congruent with the TolC coiled-coil hairpins in the iris-like opening of the TolC channel. Together, my studies suggest that rather than being a passive structural linkage between AcrB and TolC, AcrA plays an active role mediating the drug efflux. The reported AcrA dynamics provides new insights into the AcrA-TolC interactions for the channel opening during the efflux process.
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Born Globals Internationalization and Competitive advantage - A Resource-based View perspective : The case study research of Swedish Born Globals to the roles of firm Resources in firm‟s establishment, internationalization and competitive advantageNguyen, Thi Tram Anh, Yodmunee, Sopawan January 2011 (has links)
The phenomenon of Born Globals in particular to the internationalization process has been highlighted by many scholars. The insufficient of the existing researches to the ability of Born Globals going international since their inceptions with limited resources encouraged us to study more in-depth. Resource-based View (RBV) and firm‟s competitive advantage are chosen as the theoretical framework. Three Swedish Born Globals were chosen as case studies, the data was collected by semi-structure and e-mail interviews which within-case and cross-case analysis were applied. The empirical data and analysis draws us to the conclusion that human resource especially entrepreneurs and network are the key firm resources that significantly contribute to Born Globals‟ establishment, internationalization and competitive advantage. However, the finding is highlighted that entrepreneur has a crucial role to both establishment and internationalization stages. Entrepreneur‟s personal network has high contribution when Born Globals is started up while firm‟s network plays more important role at the internationalization stage. By using network, Born Globals gain an easier way to find financial and operating resource. Moreover, entrepreneur‟s capability is the main key resource that creates competitiveness to Born Global firms. Future research suggestions and implications are discussed in the conclusion.
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Analyses of Junior High School Students' Online Gaming Experiences and its Relationship with Self-concept, Life Adaptation and Well-beingHuang, Kai-Lin 06 July 2010 (has links)
The purpose of this study was to explore the junior high school students' online gaming experiences and its relationship with self-concept, life adaptation and well-being. The data was collected by means of questionnaires, and the participants were junior high school students in Kaohsiung area. The employed instruments were to reorganize questionnaires of other people. A questionnaire including basic data, scale of online game experiences, scale of online game participation motive, scale of self-concept, scale of life adaptation, and scale of well-being was implied to the studnets of 10 junior high schools in Kaohsiung area and 887 effecitve paritcipants were obtained. Finally, the data was analyzed with the methods of Chi-square test, Independent t-test, MANOVA, Multiple Regression Analysis. The results of this study were as following:
1. At present, 68.5% of junior high students participate in online games. Among them, most students choose to play free online games at home.
2. In the online gaming participation rate, player experiences, everyday average time of playing online games and participation motive, boys are significantly higher than girls.
3. Parents don¡¦t restrict children to play online games, and then children spend longer time playing online games and the motive in playing online games is stronger.
4. Compared with the non-experience, students who have online gaming experiences have poor ¡§family self¡¨, but have better ¡§physical self¡¨.
5. Compared with students of having online gaming experiences, students who don¡¦t have online gaming experience have better ¡§life adaptation¡¨.
6. ¡§Self-assurance¡¨ dimensions, ¡§social interaction¡¨ dimensions and ¡§recreation amusement ¡§ dimensions of the online gaming participation motive toward self-concept, life adaptation and well-being are low explanation. That shows other important factors need exploring.
Finally, some practical suggestions based on the results of this study were provided to those related education organizations, teachers, parents, and researchers as the references in the future.
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The effect of Uplink and Downlink relationship within Multi-level Marketing SalesTsai, Chin-Chang 10 November 2000 (has links)
Abstract
In this research we focus on MLM companies in Taiwan area, interrelationship between each direct sales and how their own characteristics affect business. Our goal is to understand the uplink and downlink interrelationship in order to improve the their relationship in direct sales companies. This will promote the uplink to help downlink into fast development state and improve the business.
As for MLM system, every direct sale does not have legal contract with MLM Company and every marketing unit act as an independent unit. On the other hand, every direct sales requires other units for support and makeup the whole MLM system. Therefore, the relationship between uplink and downlink is the base and strength element of MLM system.
Researchers discover that direct sales joins in the MLM system is based on product requirement market more than open market or potential market. Therefore, all those direct sales need to take product requirement market into concern. If the product has large requirement market then it will be easier for the direct sales to expend their MLM system. For those people who did not join into direct sale their direct downlink will be their classmates and friends. In long term direct sales marketing, classmates and friends market are not enough, we need to walk out and open stranger market. In order to gain new market we need to continuously build up new relationship with all kind of people and only this will continuously expend the direct sales market.
After direct sales join the MLM system, during the interaction with uplink it will go through initial state, enhance state, stable state and independent state four different states. Every single state will affect the relationship between uplink and downlink on how they build up, maintain and expend. During the direct sales time period we need to think of different tactics base on each state in order to achieve successful direct sales marketing. During each state when we are the uplink then we need to think how to lead the downlink into the whole system and make them become one of the whole system. In order to build up the long term relationship between direct sales and direct sales system is based on trust and mutually beneficial.
In direct sales market the relationship between uplink and downlink makeup the base strength of the whole direct sales system. Therefore, enhance the relationship between the uplink and downlink is the key element in successful direct sales market. When direct sales are leading all the downlink they need to use admiration and inspirer as enhance elements. Let downlink learn, grow and independent and lead into road of success. Direct sales market mainly focus on ¡§duplicate¡¨. Therefore, uplinks pass all kind of successful ideas into downlinks and build up the strength base on the interaction between uplinks and downlinks. This is the truth strength behind the MLM.
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An Investigation of the Donation Willingness of the Donators of the Non-Profit Organizations: A Comparison Between Religious and Non-religious OrganizationsHsin, Jia-chen 22 June 2009 (has links)
Because of the diversity of the society,the contents of the service and production provided by the public department (Government) and the private department (Business) can not fit the present and future needs. Based on the failures of the functions of the society and the government,NPO or NGO is flourishing to make up for the insufficiency of the two departments.
There is a vigorous development of NPOs in Taiwan since 921 earthquake,and the numbers of NPOs rise steeply.As to NPOs,it is very critical to understand the donation willingness of the donators on the situation of limited society resources and private donations.
The goals of the research are to discuss the donation willingness of the donators of the NPOs including the personalities, motives, religious beliefs of the donators,the fame of NPOs,the extent of expositions of information and the usage of the donation.And then probe the causes of the donation willingness of the donators.
The goals of the rsearch are as following:
1.To probe the recognition of the NPOs managers,volunteers and donators to influence the donation willingness of the donators in Kaohsiung district.
2.To analyze the factors that influence the donators of the NPOs in Kaohsiung district.
3.To provide the suggestions to the managers of the NPOs in Kaohsiung district.
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Implicit personality and leadership in stressful and dangerous situations: a first stepSmith, Daniel R. 05 April 2012 (has links)
Leadership in stressful and dangerous situations is vitally important in terms of lives, property, and national strategic objectives. But our understanding of effective leadership in these and other contexts is limited. Part of the problem is that interactionist theoretical perspectives are not reflected in contemporary leadership thinking. In addition, the impact of individual differences on leadership is often misrepresented or hidden by linear correlations and regressions conducted on continuous scores. This study employed new, innovative, indirect conditional reasoning measures to assess the personalities of 627 leaders entering the militaryâ s most challenging and stressful combat leader development course (the US Army Ranger School). These innovative measures predicted compelling differences in leadership, attrition, and in the peer evaluations made during the training. Analyses conducted on the continuous personality scores demonstrate that these findings are misrepresented or hidden by linear correlations and regressions. As an alternative, I present a configural scoring scheme, couched in a poker analogy, to explain how these individual differences combine to predict the odds of success for each of the 18 personality types studied.
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Operation Ajax : Studie om USA:s och Storbritanniens involvering i statskuppen, Iran 1953Panahirad, Ashkan January 2008 (has links)
<p>University of Växjö, School of Social Sciences</p><p>Course: PO 5363, Political Science, G3</p><p>Title: the Role of the USA’s and Great Britain in the Coup d'Etat, Iran 1953</p><p>Author: Ashkan Panahirad</p><p>Supervisor: Lennart Bergfeldt</p><p>The purpose of this study is to examine Great Britain’s and US’ motives and action alternatives in regards to the Coup d'état against the iranian regime under Mossadegh in 1953.</p><p>The method used is motive analysis (investigates the actors motives). The theories used are Rational actors model and Governmental politics. Rational actor model allows states to choose among a set of alternatives displayed in a particular situation in order to achieve their goals. Governmental politics explains what happens in states as a result of bargaining games between important actors in the government.</p><p>Analysis from the rational actor model shows that the motives behind the Coup d'état were oil, economical reasons, Iran and communism. Coup d'état was the most rational action for them to achieve their goals. Governmental politics reveal the shifting of policies from one administration to another. While Clement Attlee’s government and Harry Truman’s administration where more moderate, Winston Churchill’s and Eisenhower’s where more eager to replace Mossadegh, which finally lead to a Coup d'état</p>
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Toward an integrated communication theory for celebrity endorsement in fund raising [electronic resource] / by Tracie M. Domino.Domino, Tracie M. January 2003 (has links)
Title from PDF of title page. / Document formatted into pages; contains 117 pages. / Thesis (M.A.)--University of South Florida, 2003. / Includes bibliographical references. / Text (Electronic thesis) in PDF format. / ABSTRACT: Throughout the history of the United States, Americans customarily have given away their money, as well as their time to serve the common good. Americans will give "to build something, to fight something, or to save something" (Fink, 1990, p. 136). They make gifts to causes, or the societal problems represented by organizational missions, that are important to them. Individuals give not only to advance a common good, but also to receive private goods, or benefits that are internal, intangible, and in some cases, tangible (Steinberg, 1989). To create this feeling of reciprocity for prospective donors who have not actually benefited from the organization, charitable organizations attempt to attract these individuals by providing them with a benefit from the organization as a result of their donation of time or money. / ABSTRACT: A benefit many individuals are now receiving as a result of their donations is the personal association, real or perceived, with a celebrity (Wheeler, 2002). Preliminary empirical evidence suggests that celebrities are more effective as endorsers when they are personally connected to a cause not only because they help raise awareness for the cause, but they also have a perceived higher level of involvement in the organization. To date, most celebrity endorsement research remains in the field of marketing, while fund raising is more effective when discussed from the public relations perspective (Kelly, 1991, p. 163). However, there currently is no discipline-specific public relations theory that merges the concept of celebrity endorsement with the concepts of symmetrical and asymmetrical fund raising. / ABSTRACT: Fortunately, the interdisciplinary nature of public relations fosters the use of theoretical constructs from other areas of the social sciences, including marketing research (Werder, 2003). The mixed motive model of public relations (Dozier, L. Grunig, & J. Grunig, 1995) provides a framework when it is adapted to guide celebrity endorser fund raising success on a continuum between marketing and public relations. This study did not find support for the integrated communication model of celebrity endorsement fund raising since no significant differences existed between the different endorsers ability to increase the active seeking of information and acting on that information, information processing, and willingness to donate money and volunteer time for a charitable organization. / System requirements: World Wide Web browser and PDF reader. / Mode of access: World Wide Web.
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Teroro akto sudėties požymiai ir jų atribojimas nuo kitų nusikalstamų veikų pagal Lietuvos Respublikos baudžiamąjį kodeksą / The features of terror act’s consist and it’s delimitation from other criminal acts according to the Penal code of Lithuanian RepublicGrybytė, Lina 22 January 2009 (has links)
Darbe norima atskleisti teroro akto sudėties požymius, nustatyti atskyrimo nuo kitų nusikalstamų veikų galimybes. Keliama hipotezė, kad Lietuvos Respublikos baudžiamajame kodekse teroro akto sudėties požymiai nėra pakankamai apibrėžti.
Akcentuojama teroro, teroro akto ir terorizmo sampratų atskyrimo problema. Autorė pastebi, kad atsiranda vis daugiau mokslinių darbų terorizmo tematika, daugeliu atvejų tai politologinio ar istorinio pobūdžio darbai, daugiau analizuojantys terorizmo padarinius, terorizmo paplitimą ar teroristinių organizacijų veiklą, mažai dėmesio skiriant teroro aktų, kurie yra priemonė teroristinei ideologijai sklisti, sudėties analizei, kurios požymiai nepakankamai reglamentuoti ir Lietuvos Respublikos baudžiamajame kodekse. Darbe siekiama terorizmą ir teroro aktus atskirti, teroro aktą apibrėžiant kaip nusikalstamą veiką, individualią, nepakartojamą, neatsiejamą nuo konkrečių asmenų – teroro aktus realizuojančių asmenų ir jų aukų. Darbe atskleidžiamas ir teroro, kaip iracionalios baimės kūrėjo, vaidmuo teroro akte.
Remiantis Lietuvos Aukščiausiojo Teismo sprendimais, tarptautinės teisės aktais, kitais moksliniais darbais, magistro darbe formuluojamos teroro akto sudėtyje minimos sąvokos. Pabrėžiama visuomenės saugumo, kaip baudžiamojo įstatymo saugomos vertybės, į kurią kėsinamasi teroro aktu, svarba. Visuomenės saugumas apibūdinamas kaip būsena be grėsmių, grėsmę suvokiant kaip realią galimybę sukelti konkrečią žalą saugomam objektui (pvz., strateginės... [toliau žr. visą tekstą] / In this work the author is trying to describe the features of terror act, identify possibilities of delimitation from other criminal acts. There is created a hypothesis, that in the Penal code of Lithuania Republic the features of terror acts’ consist are not clearly defined.
There is emphasized the problem of differentiation of terror, terror act and terrorism concepts. The author is noticing that there are more studies about terrorism, in many cases they are of political or historical character, more analyzing the issues of terrorism, its’ spread ant the activity of terrorist organizations, paying less attention for the analysis of terror acts, that are means for spreading terrorist ideology. In this work there is trying to distinguish terrorism and terror act, describing as criminal act, individual, unrepeatable, concurrent from concrete person, who realize these terror acts and its’ victims. In this work also is revealed terror’s, as creator of irrational fair, role in terror act.
Following the decisions of Lithuania High Court, international juridical acts, other research work, in this master work are formulated concepts concerning the consist of terror act. There is emphasizing the importance of society’s security as worth in penal law, which can be attempting by terror act. Society’s security is described as state without danger, in this case danger is comprehensible as real possibility to make harm for saved objects (for example, strategic objects, the destruction of... [to full text]
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