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681	Variable selection and structural discovery in joint models of longitudinal and survival data He, Zangdong January 2014 (has links) Indiana University-Purdue University Indianapolis (IUPUI) / Joint models of longitudinal and survival outcomes have been used with increasing frequency in clinical investigations. Correct specification of fixed and random effects, as well as their functional forms is essential for practical data analysis. However, no existing methods have been developed to meet this need in a joint model setting. In this dissertation, I describe a penalized likelihood-based method with adaptive least absolute shrinkage and selection operator (ALASSO) penalty functions for model selection. By reparameterizing variance components through a Cholesky decomposition, I introduce a penalty function of group shrinkage; the penalized likelihood is approximated by Gaussian quadrature and optimized by an EM algorithm. The functional forms of the independent effects are determined through a procedure for structural discovery. Specifically, I first construct the model by penalized cubic B-spline and then decompose the B-spline to linear and nonlinear elements by spectral decomposition. The decomposition represents the model in a mixed-effects model format, and I then use the mixed-effects variable selection method to perform structural discovery. Simulation studies show excellent performance. A clinical application is described to illustrate the use of the proposed methods, and the analytical results demonstrate the usefulness of the methods. Joint models Mixed effect selection Structural discovery Adaptive LASSO Gaussian quadrature EM algorithm Regression analysis -- Data processing Numerical analysis -- Data processing Spectral theory (Mathematics) Estimation theory -- Analysis Statistics -- Data processing Calculus of variations Structural bioinformatics Parameter estimation
682	Multivariate semiparametric regression models for longitudinal data Li, Zhuokai January 2014 (has links) Multiple-outcome longitudinal data are abundant in clinical investigations. For example, infections with different pathogenic organisms are often tested concurrently, and assessments are usually taken repeatedly over time. It is therefore natural to consider a multivariate modeling approach to accommodate the underlying interrelationship among the multiple longitudinally measured outcomes. This dissertation proposes a multivariate semiparametric modeling framework for such data. Relevant estimation and inference procedures as well as model selection tools are discussed within this modeling framework. The first part of this research focuses on the analytical issues concerning binary data. The second part extends the binary model to a more general situation for data from the exponential family of distributions. The proposed model accounts for the correlations across the outcomes as well as the temporal dependency among the repeated measures of each outcome within an individual. An important feature of the proposed model is the addition of a bivariate smooth function for the depiction of concurrent nonlinear and possibly interacting influences of two independent variables on each outcome. For model implementation, a general approach for parameter estimation is developed by using the maximum penalized likelihood method. For statistical inference, a likelihood-based resampling procedure is proposed to compare the bivariate nonlinear effect surfaces across the outcomes. The final part of the dissertation presents a variable selection tool to facilitate model development in practical data analysis. Using the adaptive least absolute shrinkage and selection operator (LASSO) penalty, the variable selection tool simultaneously identifies important fixed effects and random effects, determines the correlation structure of the outcomes, and selects the interaction effects in the bivariate smooth functions. Model selection and estimation are performed through a two-stage procedure based on an expectation-maximization (EM) algorithm. Simulation studies are conducted to evaluate the performance of the proposed methods. The utility of the methods is demonstrated through several clinical applications. Biostatistics Estimation theory -- Research Biometry -- Methodology -- Research Binary system (Mathematics) -- Research Nonparametric statistics -- Research Probabilities -- Data processing Real-time data processing -- Research Parameter estimation -- Research Latent variables -- Research Meta-analysis -- Research -- Methodology Stochastic processes -- Research Least squares -- Research
683	Revision of an artificial neural network enabling industrial sorting Malmgren, Henrik January 2019 (has links) Convolutional artificial neural networks can be applied for image-based object classification to inform automated actions, such as handling of objects on a production line. The present thesis describes theoretical background for creating a classifier and explores the effects of introducing a set of relatively recent techniques to an existing ensemble of classifiers in use for an industrial sorting system.The findings indicate that it's important to use spatial variety dropout regularization for high resolution image inputs, and use an optimizer configuration with good convergence properties. The findings also demonstrate examples of ensemble classifiers being effectively consolidated into unified models using the distillation technique. An analogue arrangement with optimization against multiple output targets, incorporating additional information, showed accuracy gains comparable to ensembling. For use of the classifier on test data with statistics different than those of the dataset, results indicate that augmentation of the input data during classifier creation helps performance, but would, in the current case, likely need to be guided by information about the distribution shift to have sufficiently positive impact to enable a practical application. I suggest, for future development, updated architectures, automated hyperparameter search and leveraging the bountiful unlabeled data potentially available from production lines. artificial neural networks machine learning deep learning connectionism pattern recognition machine learning automation image analysis information technology applied mathematics mathematical optimization information theory mathematical statistics mathematical models stochastic models probabilities chance approximations algorithms computer programs computer software signal processing high performance computing numerical methods high technology industries sustainable development artificiella neurala nätverk maskininlärning djup maskininlärning konnektionism mönsterigenkänning automatisering bildanalys informationsteknik tillämpad matematik optimering informationsteori statistisk inferens matematiska modeller stokastiska modeller sannolikhetskalkyl slumpen approximationer algoritmer datorprogram programvara signalbehandling högpresterande beräkningar numeriska metoder teknikutveckling maskinindustri högteknologisk industri maskinhandel skrothandel bärkraftig utveckling Robotics Robotteknik och automation Probability Theory and Statistics Sannolikhetsteori och statistik Other Computer and Information Science Annan data- och informationsvetenskap Signal Processing Signalbehandling

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