Submitted by Juliana Mitre (julianamitre@yahoo.com.br) on 2018-09-09T22:00:06Z No. of bitstreams: 1 TESE FGV Juliana Mitre 23 06 18 LS (4).pdf: 1030135 bytes, checksum: 0415f2e33ea986fa2a52142549c9a5f9 (MD5) / Approved for entry into archive by Simone de Andrade Lopes Pires (simone.lopes@fgv.br) on 2018-09-11T19:35:19Z (GMT) No. of bitstreams: 1 TESE FGV Juliana Mitre 23 06 18 LS (4).pdf: 1030135 bytes, checksum: 0415f2e33ea986fa2a52142549c9a5f9 (MD5) / Rejected by Suzane Guimarães (suzane.guimaraes@fgv.br), reason: Prezada Juliana, O PDF submetido contém grifos no texto, erro de código na lista de tabelas e marcações de revisão, não podendo ser considerado como versão final. Submeter novamente o arquivo corrigido. Atenciosamente, on 2018-09-12T16:51:54Z (GMT) / Submitted by Juliana Mitre (julianamitre@yahoo.com.br) on 2018-09-14T18:39:26Z No. of bitstreams: 1 Arquivo 14-09-2018 3 33 28 PM.pdf: 1156648 bytes, checksum: cac5a8aafe840bcdceb4c22c733e7b63 (MD5) / Approved for entry into archive by Simone de Andrade Lopes Pires (simone.lopes@fgv.br) on 2018-09-14T20:05:05Z (GMT) No. of bitstreams: 1 Arquivo 14-09-2018 3 33 28 PM.pdf: 1156648 bytes, checksum: cac5a8aafe840bcdceb4c22c733e7b63 (MD5) / Approved for entry into archive by Suzane Guimarães (suzane.guimaraes@fgv.br) on 2018-09-17T12:17:17Z (GMT) No. of bitstreams: 1 Arquivo 14-09-2018 3 33 28 PM.pdf: 1156648 bytes, checksum: cac5a8aafe840bcdceb4c22c733e7b63 (MD5) / Made available in DSpace on 2018-09-17T12:17:17Z (GMT). No. of bitstreams: 1 Arquivo 14-09-2018 3 33 28 PM.pdf: 1156648 bytes, checksum: cac5a8aafe840bcdceb4c22c733e7b63 (MD5) / Esse trabalho busca analisar a satisfação do cliente na prestação de serviços oftalmológicos oferecidos pelo Hospital de Olhos de São Paulo (HOSP), organização que enfrentou importante crise financeira nos últimos anos que afetou a qualidade dos serviços. Para avaliar a satisfação do cliente neste contexto, foi aplicado questionário de satisfação do paciente em uma das unidades, com o objetivo de identificar aspectos a melhorar e assim redirecionar a estratégia organizacional. 184 pacientes responderam à pesquisa que incluiu a utilização do indicador Net Promoter® Score (NPS® ). 60% dos respondentes eram do sexo feminino, cerca de 70% já eram clientes e estavam retornando ao serviço. Desses, 39% retornaram pela localização e 29% pela qualidade do atendimento. 30% eram casos novos, sendo que desses, 41% vieram por indicação de amigos e 39% pelo convênio. Ao aplicar-se o NPS® , o HOSP obteve score de 63%, o que corresponde à chamada zona de qualidade, na qual a maioria dos clientes é considerada neutra, pois não difamam e nem indicam o Hospital; o que não é bom para um serviço que preza pela excelência em Oftalmologia. Com base nessa pesquisa, foram levantados os pontos falhos para posteriormente se criar um plano de melhorias para o Grupo HOSP com o objetivo de aumentar o número de clientes promotores e diminuir o de detratores, o que poderá auxiliar na busca por novos clientes e aumentar a competitividade no mercado paulista. / This study aims to analyze the satisfaction of the client in the provision of ophthalmological services offered by Hospital de Olhos de São Paulo (HOSP), an organization that faced an important financial crisis in the last years that affected the quality of the service. To assess client satisfaction in this context, a patient satisfaction questionnaire was applied in one of the units, aiming to identify aspects to improve and thus to redirect the organizational strategy. 184 patients responded to the survey that included the use of the Net Promoter® Score (NPS®) indicator. 60% of the respondents were female, some 70% returned to the service (of these, 39% returned for the location and 29% for the quality of care) and 30% were new cases (41% indicated by friends and 39% by agreement). When applying NPS®, the HOSP obtained a score of 63%, which corresponds to the so-called quality zone, in which most clients are considered neutral, since they do not slander or indicate the Hospital; which is not good for a service that values excellence in ophthalmology. Based on this research, all the flaws were raised to later create an action plan for the HOSP Group with the objective of increasing the number of promoters and reducing the number of detractors, which may help in the search for new clients. Similar surveys will be carried out periodically so that the service can improve continuously and maintain its competitiveness in the São Paulo market.

This thesis, New Psychoactive Substances in British Drug Policy Discourse addresses new psychoactive substances (NPS) in drug policy discourse in Great Britain between 2000-2014. It focuses on the identification of individual frames and aims to understand the different perspectives NPS can be framed in The theoretical framework of this thesis is based on the idea of social constructivism and Frame Theory. On this basis, the thesis identifies individual sponsors, the general characteristics of the problem, the injured party, the public policy implications and the value base. It identifies four frames which are present in the discourse. The first, called Fragmented, does not perceive NPS as a comprehensive problem, but as individually occurring substances. The second frame the Prohibitionist wishes to tackle the issue of NPS using new tools of prohibition. The third one, the Regulatory frame is strongly polarized towards the previous frame and wants to solve the NPS issue by creating a legally regulated market for psychoactive substances. The last, Wicked frame, perceives NPS as an unstructured problem, therefore it cannot be solved by one measure. This frame favors an expert debate and evidence in order to find the optimal solution. The thesis puts the issue into context and focuses on NPS...

This thesis examines the development of Wahhabism as an ideology into a rapidly expanding, transportable, contemporary Islamic political system. Serving as the territorial foundation, individuals maintain allegiance to Makkah, the center of the Islamic world, through symbolic Islamic prayer. Along with a central, globally financed economic distributive mechanism, and Wahhabi social and educational institutions emerging from the traditional mosque, Wahhabism serves the demand for an Islamic political system in a late capitalist world. Wahhabism is fluid within contemporary dynamic political systems and rapidly changing international relations. Wahhabism continues to expand at a global level, at times, providing a foundation for new forms of contemporary terrorism.

En raison de la diffusion incontrôlée sur le e-commerce, la sécurité et l’alternative légale aux stupéfiants habituels, les nouvelles substances psychoactives (NPS), d’apparition récente (2008), sont au cœur des phénomènes récents d’addiction et de décès mal expliqués. Au-delà des différents défis dans nos sociétés (prévention, législation), la capacité d’identifier les NPS dans des échantillons biologiques pour caractériser leur utilisation, présente de nombreux challenges analytiques. L’objectif principal de cette thèse a été de collecter des échantillons biologiques (sang, urine, cheveux) provenant de cas d’exposition à des NPS et d’y caractériser les substances présentes à l’aide de méthodes analytiques originales, dans le but d’enrichir les librairies de spectres de masse et d’améliorer, en conséquence, la détection de la consommation de NPS. En particulier, il s’agissait d’augmenter la fenêtre de détection de la prise de NPS en se focalisant sur les métabolites qui sont, le plus souvent, les produits majeurs d’élimination. Le développement analytique, par chromatographie liquide ultra haute performance couplée à la spectrométrie de masse en tandem (UHPLC-MS/MS), a demandé plusieurs mois d’optimisation afin d’obtenir une méthode robuste, exhaustive et sensible. Actuellement, la librairie de spectres MS comporte 114 NPS et est mise à jour régulièrement. A la suite de ce développement, ma thèse a porté sur l’étude de cas d’intoxication vus au service des urgences du CHU de Strasbourg, mais aussi en médecine légale, avec des situations de décès et d’identification de produits inconnus provenant de saisies (poudres et cristaux). Il a également été nécessaire de développer des outils analytiques complémentaires, tels que la caractérisation de métabolite(s) par étude sur microsomes hépatiques humains (HLMs), et l’utilisation de la spectroscopie par résonance magnétique nucléaire (RMN) afin d’identifier avec certitude certains composés et de déterminer leur degré de pureté. Les outils analytiques développés et la stratégie mise en place ont permis la rédaction de 18 publications, ainsi que l’agencement de nombreuses collaborations. / Due to the uncontrolled spread on the Internet and their legal alternative to usual drugs, the new psychoactive substances (NPS), recently appeared (2008), are at the center of recent phenomena of addiction and badly explained deaths. Beyond different challenges in our societies (prevention, legislation), the ability to identify NPS in biological samples, in order to characterize their use, presents many analytical challenges. The main objective of this thesis was to collect biological samples (blood, urine, hair) from cases of exposure to NPS and to characterize the substances present using original analytical methods, in order to enlarge the libraries of mass spectra and improve, as a result, the detection of NPS consumption. In particular, it was intended to increase the detection sensitivity of NPS intake by focusing on the metabolites that are often the major products of elimination. This analytical development, by ultra-high liquid chromatography coupled with tandem mass spectrometry (UHPLC-MS/MS), required several months of optimization in order to obtain a robust, exhaustive and sensitive method. At present, the mass spectra database has 114 NPS and is regularly updated. Thereafter, ma thesis focused on the study of cases of intoxication observed in the emergency department of Strasbourg, but also in legal medicine with situations of deaths and identification of unknown products collected from seizures (powders and crystals). It has also been necessary to implement complementary analytical tools, such as the characterization of metabolites by human liver microsomes (HLMs), and the use of nuclear magnetic resonance (NMR) spectroscopy to accurately identify the compounds and establish their purity degrees. The analytical tools developed, and the strategy adopted, allowed the writing of 18 publications, as well as the setting up of numerous collaborations.

No description available.

>Magister Scientiae - MSc

>Magister Scientiae - MSc / The Kuils River Catchment is an urban river catchment that forms part of the larger Kuils-Eerste River system draining the eastern half of the Cape Metropolitan Authority area and Stellenbosch Municipality. Rapid urbanisation has resulted in the encroachment of residential and industrial areas into the river system through channelization and sewage disposal. This research project intends to assess the quality of surface runoff in the Kuils River catchment and determining non-point source pollutant loading rates in the catchment using GIS-based modelling. The study results show how modelled potential sources of surface runoff and NPS pollutants using desktop GIS analysis tools in a sequential process that involved different levels of software applications could explain the characteristics of the catchment. With the help of the Expected Mean Concentration (EMC) values associated with surface runoff from land use/covers, NPS pollutant loads were assessed downstream towards the Kuils River Catchment outlet using the Nonpoint Source Pollution and Erosion Comparison Tool (N-SPECT) based in ArcGIS. The outputs from this model consist of predicted annual pollutant loading (mg/mvyear) for each Kuils-Eerste River that occurs in the catchment. The results have shown clearly the spatial distribution of sources of particular pollutants in the catchment. Further or advanced processing knowhow with this model might provide far reaching insights into the problem and it is however recommended that these results produced using N-SPECT be compared to those of other hydrologic models using the same inputs.

Les membranes biologiques sont impliquées dans divers mécanismes comme la reconnaissance moléculaire ou encore la fusion membranaire. Les lipides, principaux composants des membranes, sont inhérents à ces processus cellulaires, mais leur organisation et leur rôle fonctionnel au sein de ces systèmes sont très complexes. Dans ce travail, nous avons utilisé des modèles membranaires mimant ces systèmes biologiques pour identifier les interactions mises en jeu avec divers agents exogènes (AEs), en utilisant la microscopie à force atomique (AFM). Nous avons donc travaillé sur deux AEs différents qui interagissent potentiellement avec ces membranes. Le premier intervient directement dans le cadre de l'étude du paludisme. Le mécanisme moléculaire de cette maladie (impliquant probablement des structures lipidiques) n'étant pas clair, la compréhension de celui-ci faciliterait le développement de nouvelles molécules antipaludiques et/ou cibles thérapeutiques. Parallèlement notre étude s'est portée sur l'interaction des nanoparticules (NPs) de TiO2, notre second AE, avec les membranes. Très utilisées dans l'industrie, ces NPs de TiO2 pourraient avoir un impact sur la santé humaine, en interagissant notamment avec les membranes cellulaires. Des techniques biophysiques classiques ont tout d'abord été utilisées pour évaluer l'interaction de l'AE avec des systèmes biomimétiques. Ensuite, lorsque celle-ci est prouvée, l'AFM est utilisée pour visualiser les changements morphologiques des modèles membranaires en présence de ces AEs. Ainsi, pour chaque AE, nous avons finalement suggéré un mécanisme d'interaction afin de répondre aux problématiques soulevées.

Compte tenu du récent taux alarmant d'épuisement des réserves de combustibles fossiles et de l'augmentation drastique des niveaux de CO2 dans l'atmosphère qui a conduit au réchauffement de la planète et à des changements climatiques sévères, l'exploitation de toutes sortes d'énergies renouvelables a été la Parmi les principales priorités de la recherche Champs à travers le monde. L'une des nombreuses voies de ce genre est la réduction du CO2 aux combustibles utilisant des énergies renouvelables, plus communément appelées cellules photoélectro-catalytiques (PEC). Des essais expérimentaux sur la réduction du CO2 ont été réalisés sur différents types de catalyseurs dans les deux cellules (Conçu par un laboratoire) afin de comprendre la sélectivité, la productivité et les produits de réaction obtenus. Des essais expérimentaux ont été réalisés sur différents types de catalyseurs à la fois dans les cellules en phase gazeuse et en phase liquide pour comprendre la sélectivité, la productivité et les produits de réaction obtenus. Pour les études sur la réduction EC du CO2 en phase gazeuse, une série d'électrodes (à base de nanoparticules (NPs) de Cu, Fe, Pt et CuFe déposées sur des nanotubes de carbone ou de noir de carbone puis placées à l'interface entre une membrane Nafion et Une électrode à couche de diffusion de gaz). Les résultats démontrent le type divers de produits formés et leurs productivités. Dans des conditions sans électrolyte, la formation de produits ≥C1 tels que l'éthanol, l'acétone et l'isopropanol a été observée la plus élevée étant pour Fe et suivie de près par Pt. Pour améliorer Combustibles nets, un ensemble différent d'électrodes a été préparé sur la base de revêtements MOF de type imidazolate de type zéolitique substitué (SIM-1) (Fe-CNT, Pt-CNT et CuFe-CNT basés sur MOF) Et Pt-MOF a montré des carburants améliorés. En se reportant aux études sur la réduction EC du CO2 dans une cellule en phase liquide, un ensemble similaire d'électrodes a été prepare (NP - Cu, Fe, Pt, Ru, Co déposées sur des nanotubes de carbone ou du noir de carbone ont). Pour les conditions de phase liquide, en termes de produits C nets, les électrodes catalytiques à base de Pt sont en tête de la catégorie, suivies de près par Ru et Cu, tandis que Fe a obtenu la position la plus basse. Le mécanisme réactionnel sous-jacent probable a également été fourni. Afin d'améliorer encore les performances, on a synthétisé des NP de metal (Ru, Fe, Pt et Cu) de différentes tailles en utilisant différentes techniques de synthèse: (i) l'itinéraire d'imprégnation (ImR) pour obtenir des NP dans la plage de tailles de 10 à 50 nm; (Ii) Approche organométallique (OM) pour synthétiser des NPs uniformes et ultrafines dans la plage de tailles de 1-5 nm. Fe ont été synthétisés par une nouvelle voie de synthèse et des conditions pour atteindre des NP de 1 à 3 nm. (Iii) Approche de haut en bas de Nanowire pour obtenir des NP de cuivre ultrafin dans la plage de taille de 2-3,8 nm. Les améliorations apportées à la productivité du carburant se sont révélées être de 5 à 30 fois plus élevées pour les petites NP sur les NP plus importantes et, en outre, une charge réduite de 10 à 1-2% en poids. Un autre ensemble d'électrodes à base de nano-mousses (Cu NF et Fe NF sur Feuille de Cu, Feuille de Foie, Al Foil, Inconel foil et Al grid / mesh) préparés par électrodéposition ont également été étudiés afin d'améliorer encore la conversion de CO2 / carburant. Après, l'optimisation du dépôt et de la tension à l'aide de la voltamétrie cyclique, les carburants se sont améliorés de 2 à 10 fois par rapport aux combustibles nets les plus élevés obtenus à l'aide d'électrodes CNT dopées à base de NP / In view of the recent alarming rate of depletion of fossil fuel reserves and the drastic rise in the CO2 levels in the atmosphere leading to global warming and severe climate changes, tapping into all kinds of renewable energy sources has been among the top priorities in the research fields across the globe. One of the many such pathways is CO2 reduction to fuels using renewable energies, more commonly referred as photo-electro-catalytic (PEC) cells. Experimental tests were carried out on various types of catalysts in both the gas and liquid phase cells (lab-designed) to understand the different selectivity, productivity and the reaction products obtained. For the studies on the EC reduction of CO2 in gas phase cell, a series of electrodes (based on Cu, Fe, Pt and Cu/Fe metal nanoparticles – NPs - deposited on carbon nanotubes – CNTs - or carbon black and then placed at the interface between a Nafion membrane and a gas-diffusion-layer) were prepared. Under gas phase, the formation of ≥C1 products (such as ethanol, acetone and isopropanol) were observed, the highest being for Fe and closely followed by Pt, evidencing that also non-noble metals can be used as efficient catalysts under these conditions. To enhance the net fuels, a different set of electrodes were also prepared based on substituted Zeolitic Imidazolate (SIM-1) type MOF coatings (MOF-based Fe-CNTs, Pt-CNTs and Cu/Fe-CNTs) and Pt-MOF showed improved fuels. Moving to the studies on the EC reduction of CO2 in liquid phase cell, a similar set of electrodes were prepared (metal NPs of Cu, Fe, Pt, Ru and Co deposited on CNTs or carbon black). For liquid phase conditions, in terms of net C-products, catalytic electrodes based on Pt topped the class, closely followed by Ru and Cu, while Fe got the lowest position. The probable underlying reaction mechanism was also provided. In order to improve further the performances, varied sized metal NPs (Ru, Fe, Pt and Cu) have been synthesized using different techniques: (i) impregnation (ImR) route to achieve NPs in the size range of 10-50 nm; (ii) organometallic (OM) approach to synthesize uniform and ultrafine NPs in the size range of 1-5 nm (i.e., Fe NPs were synthesized through a novel synthesis route to attain 1-3 nm NPs); (iii) Nanowire (NW) top-down approach to obtain ultrafine copper metal NPs in the size range of 2-3.8 nm. The enhancements in the fuel productivity were found to be 5-30 times higher for the smaller metal NPs over the larger metal NPs and moreover, with reduced metal loading from 10 to 1-2 wt %. A different set of electrodes based on nano-foams (Cu NF and Fe NF on Cu foil, Fe foil, Al foil, Inconel foil and Al grid/mesh) prepared via electro-deposition were also investigated, to further improve CO2 to fuels conversion. After, optimization of deposition and voltage using cyclic voltammetry, the fuels improved by 2-10 times over the highest net fuels achieved using metal NPs doped CNT electrodes

The customer's taste is with the transition with constant time ¡A space¡A as the order pours into constantly¡A what an attitude the manufacturing plant is!¡A the flexible company quick in response turn into the existence ways of enterprises in the future¡A and under facing and producing state that must be expanded¡A how to set up production line and efficient duplicating the productive attitude fast fast¡A is it reach quantity produce quality that customer want fast ¡A must is it is it waste carry on procedure transformation to reduce to come through NPS (New Production Skill ) to come. This research is mainly to visit the arrangement which refers to the theory of relevant documents to review and study through the executive inside the company¡A to understand the company understand the themes studied from the doing in the test amount factor of expanding the factory¡A set up NPS to be flat to take production line while being accurate ¡A utilize relevant step in accordance with follow ¡A make similar industry to establish NPS production line have one procedure way in accordance with following fast future.