Orientador: Aulus Cavalieri Carciofi / Banca: Aparecido Antonio Camacho / Banca: Ingrid Dick de Paula / Resumo: O objetivo deste trabalho foi investigar o efeito do suporte nutricional assistido sobre a taxa de alta de cães e gatos hospitalizados. Foram incluidos no estudo um grupo de 947 animais hospitalizados no período de março de 1998 a dezembro de 2000 que não receberam assistência nutricional (G1) e 522 animais, hospitalizados no período de março de 2003 a dezembro de 2005 que foram manejados nutricionalmente (G2). Para a comparação de G1 versus G2 empregou-se o teste t. Em G2 empregou-se o Qui-quadrado e a Correlação de Spearman para avaliar as associações entre ingestão calórica e alta, escore de condição corporal e alta, escore de condição corporal e ingestão calórica. Os pacientes de G2 apresentaram 83,16% de alta hospitalar e tempo médio de intemação de 9,42 dias, valores significantemente maiores (p<0.001) que os de G1, de 67,1% e 6,6 dias. Em G2, 63% dos animais apresentaram consumo voluntário com ou sem persuasão (92,93% de alta), 18,90% receberam terapia nutricional enteral (71,82% de alta), 6,19% alimentação forçada (75,0% de alta), 7,0% terapia nutricional parenteral (61,90 de alta) e 4,47% dos animais ficaram em jejum (38,46% de alta), demonstrando associação entre o tipo de suporte nutricional e alta hospitalar (p<O.01). Dentre os animais que receberam de 0% a 33% da necessidade energética de manutenção (NEM), 62,73% tiveram alta, dos que receberam entre 34% e 66% da NEM, 87,78% tiveram alta e para os que receberam mais de 67% da NEM, 93,28% tiveram alta, demonstrando menor mortalidade nas faixas de maior balanço calórico (p<0.001). Nas faixas de maior balanço calórico os animais permaneceram mais tempo internados (p<0.001). O escore de condição corporal não teve associação (p>0.05) com o consumo de calorias, porém apresentou dependência com as taxas de alta e óbito (p<0.01). / Abstract: The objective of the present study was to investigate the effect of an assisted nutritional support on the outcome in dogs and cats.The study involved a group of 947 animals hospitalized in the Veterinary Hospital of FCAV - Unesp, before the Clinical Nutrition Service was implemented and therefore did not receive assisted nutritional support (G1), which was compared to a group of 522 animals that were nutritionally managed (G2). The statistical analysis of the results included the t test (G1 vs. G2) and Chi-Square and Spearman's correlation to evaluate G2 (CI and outcome, body condition score and outcome, body condition score e CI).The outcome in G2 was 83.16% and TH 9.42 days, values higher than G1 with 63% and 6.6 days (p<0.001). In G2, 63% showed voluntary feed consumption (92.93% outcome), 18.90% received enteral support (71.82% outcome), 6.19% were forced fed (75.0% outcome), 7.0% received parenteral support (61.90% outcome) and 4.47% did not eat (38.46% outcome), demonstrating an association between the type of nutritional support and outcome (p<0.01). In G2, animals that received 0% to 33% of their MER had 62.7% outcome and those receiving more than 67% of their MER had 93.28% outcome, showing a lower mortality in the higher CI range (p<0.001). TH was higher in the ranges with higher CI (p<0.001). The body condition score (BCS) was not associated with the calories consumption (p>O.05), but showed dependence on outcome (p<0.01), the discharged percentages were 73.0% for animals with low BCS, 86.32% for with ideal SCS, and 83.18% for overweight animals. / Mestre

Magister Scientiae (Nutrition Management) - MSc(NM) / Acute lymphocytic leukemia (ALL) is the most common type of childhood cancer accounting for approximately 25% of cancers diagnosed in children less than 20 years of age. It originates in the bone marrow and prevents the normal manufacture of red blood cells, white blood cells and platelets. A poor nutritional status is frequently observed in children with ALL at the time of diagnosis and during treatment which may result in protein energy malnutrition if nutrition intervention is delayed. This retrospective study aims to assess the nutritional status of children newly diagnosed with Acute Lymphoblastic Leukemia (ALL) using 20 case studies between 1 January 2013 and 31 December 2014 from Sheikh Khalifa Medical City (Abu Dhabi, UAE), in order to develop an appropriate nutritional support protocol for pediatric ALL patients treated at this institution. Study Design: A retrospective descriptive case study design was used. The study population consisted of 20 electronic medical records of patients aged between 1-14 years who were newly diagnosed with Acute Lymphoblastic Leukemia (ALL) and admitted to Sheikh Khalifa Medical City for treatment during the period 1 January 2012 and 31 Dec 2014. Data Collection: Identification of suitable participants began through a review of each potential study participant`s electronic medical record. Data was collected and recorded on a data collection form (Appendix III) from the electronic medical record for each suitable participant for the following at admission and during the full duration of all phases of cancer treatment namely induction, consolidation, interim maintenance, delayed intensification and maintenance. The data collected comprised of the following: age, gender, date of diagnosis, symptoms on diagnosis, the cancer diagnosis (type and subtype), anthropometric measurements (weight, length/ height, head circumference), biochemical values (visceral proteins, blood glucose levels, hemoglobin, hematocrit, lymphocyte count), clinical assessment (stomatitis, anemia, mucositis), diet history (home feeding regimes; consumption of daily requirements; food preferences – types, textures; food allergies, food intolerances; food aversions; use of oral nutritional supplements; treatment-related side-effects; systemic related side-effects (nausea; vomiting; diarrhea; anorexia; appetite changes; taste changes; physical activity level; depression), dietary requirements (age and gender related nutritional requirements for energy, protein, fat and fluids) and indications for nutritional support (oral feeding; enteral feeding; parenteral feeding). Analysis of Results: The weights and length/ heights of participants recorded in the electronic medical records were converted to z-scores on the World Health Organization growth charts. The diet prescription of nutritional intervention was interpreted in comparison to the biochemical indices, anthropometric status and dietary intake of each participant. All the data involving changes in anthropometrics, biochemistry, diet history and nutritional interventions from each case study (from diagnosis and through all stages of treatment) was screened and compared with reference values in the context of the age and sex of the child. Evidence based nutritional guidelines were used to document the outcomes of the medical nutrition treatment provided in order to develop a nutrition support protocol for children with Acute Lymphoblastic Leukemia at Sheikh Khalifa Medical City. Results: The results showed that weight loss expressed as a percentage of body weight provided a more accurate estimate of the true significance of weight loss in subjects undergoing cancer treatment (chemotherapy) for ALL. A weight loss of greater than 5% of body weight over a period of one month is considered a sign of nutritional deprivation even if the subject is not classified as undernourished by anthropometric parameters. Subjects experienced the highest weight loss during the consolidation phase and interim maintenance phases of treatment. Conclusion: It can therefore be concluded that pediatric subjects on cancer treatment for ALL at SKMC and receiving nutritional support underwent changes in nutritional status as manifest by a reduction in more than 5% of their body weight during three phases of treatment namely induction, consolidation and interim maintenance. An appropriate nutrition support protocol was developed based on the results and experience obtained from this study for pediatric ALL patients treated at SKMC.

Este tesis fue publicado como artículo científico en la Revista Archivos de Medicina (DOI: http://doi.org/10.3823/1269) / Introducción. La nutrición en el Recién Nacido Pretérmino (RNPT) de Muy Bajo Peso al Nacer (MBPN) juega un rol importante en su recuperación y evolución general. Así, un soporte nutricional insuficiente puede resultar en un menor crecimiento y mayor incidencia de patologías, lo que perjudicaría la morbimortalidad de estos neonatos. Objetivo. Determinar la asociación entre el soporte nutricional y la mortalidad a los 28 días en RNPT de MBPN hospitalizados durante el año 2011 en la Unidad de Cuidados Intensivos Neonatales de un hospital público de referencia en Lima, Perú. Pacientes y método. Se realizó una cohorte retrospectiva con 60 historias clínicas de los RNPT de MBPN, nacidos y hospitalizados en la Unidad de Cuidados Intensivos Neonatales de un hospital de referencia durante el año 2011 en Lima, Perú. Se evaluó la evolución del soporte nutricional y del peso, y se asoció con la mortalidad. Resultados. 7 (11,7%) RNPT de MBPN fallecieron durante el estudio. Aquellos RNPT de MBPN que recibieron menos de 30 kcal/kg al tercer día, tuvieron 5 veces más riesgo de morir (IC 95% 1,1 – 23,5) con una diferencia estadísticamente significativa (p=0,036). Conclusiones. Recibir menores aportes nutricionales al tercer día está asociado con un mayor riesgo de mortalidad en estos neonatos. / Introduction. The nutrition in Very Low Birth Weight (VLBW) infants plays an important role in their recovery and overall development. Thus, an inadequate nutritional support can result in lower growth and higher incidence of diseases, which may affect the morbidity and mortality of these infants. Objective. Determine the association between the mortality at 28 days and the nutritional support given to VLBW infants hospitalized during 2011 in the Neonatal Intensive Care Unit of a public referral hospital in Lima, Peru. Patients and method. This retrospective cohort included 60 medical records from VLBW Infants, born and hospitalized during 2011 in the Neonatal Intensive Care Unit of a public referral hospital in Lima, Peru. The evolution of the nutritional support and weight was evaluated, and was associated with the mortality. Results. 7 (11.7%) VLBW infants died during the study. Those VLBW infants who received less than 30 kcal/kg on the third day, were 5 times more likely to die (CI 95% 1,1 – 23,5), with a statistically significant difference (p=0,036). Conclusions. Receive lower nutritional intake on the third day is associated with an increased risk of mortality in these infants. / Tesis

This diploma thesis deals with the topic of nutritional support in patients with neurological diseases (stroke, craniocerebral trauma, critical-illness-polyneuropathy. The aim of this thesis is to find out, how implemented unified system of nutritional support affects the well-being of patients at neuro-rehabilitation clinic Asklepios Schlossberg Klinikum in Bad König. There were observed 58 patients (33 men and 25 women) during 8 weeks. The theoretical part of this thesis describes basic components of nutrition, energy expenditure and needs, selected neurological diseases, dysphagia, malnutrition and nutrition in intensive neurological care. The practical part of the thesis analyses data obtained by the observation. There are observed changes of body weight, BMI and laboratory values of total protein and albumin in serum. These data are divided by sex, age and type of disease. Based on the results, it was found that although patients due to uniform tube feeding do not have sufficient protein intake, serum total protein and albumin levels increased. This can be caused by eating a uniform diet that contains good quality protein in patients, which suffered from hypoalbunemia at the outset of observation, also by reducing the effect of stress reactions with gradual improvement of the state and...

Orientador: Luiz Fernando de Oliveira e Silva Carvalho / Banca: Geraldo Camilo Alberton / Banca: Adolorata Aparecida Bianco Carvalho / Resumo: A transmissão pela via fecal-oral é considerada o mais importante meio de disseminação de Salmonella sp. entre os suínos. Foi comprovada que a transmissão de Salmonella sp. através do contato naso-nasal entre suínos pode ser viável. Porém, alguns experimentos não conseguiram demonstrar tal transmissão em determinados sorotipos de Salmonella enterica. Este ensaio teve como objetivo produzir infecção experimental de Salmonella enterica subsp. enterica sorotipo Panama e verificar a importância da via nasonasal na transmissão entre leitões desmamados. Seis leitões recém-desmamados foram adquiridos de granja previamente selecionada, livre de Salmonella sp. Análises bacteriológicas confirmaram que todos os animais estavam livres de contaminação por Salmonella sp. Utilizaram-se baias isoladoras que proporcionavam o contato naso-nasal e eliminavam a possibilidade de outras vias de transmissão e de contaminação externa. Três grupos foram formados: controle, sentinela e infectados. Os leitões do grupo controle e do grupo sentinela receberam, individualmente, por via oral, solução estéril, enquanto que leitões do grupo infectado receberam inóculo contendo 2,16 X 1010 UFC de Salmonella Panama. Foram alojados nos isoladores respectivos e retirados depois de 14 dias, período no qual amostras de fezes eram colhidas e avaliadas diariamente. Os animais foram necropsiados e amostras de tecidos colhidas. Realizaram-se testes bacteriológicos, ELISA e sorotipificação. Houve infecção sistêmica por Salmonella Panama nos animais do grupo infectado, porém os resultados revelaram não haver a transmissão pela via naso-nasal entre leitões desmamados, pois em nenhum momento o agente foi isolado dos animais sentinelas. / Abstract: The faecal-oral transmission is considering the most important route for transmission of Salmonella sp. between pigs. It has been proven that the Salmonella sp. transmission through the nose-to-nose contact among pigs can be viable. However, current data could not demonstrate such transmission in certain serovars of Salmonella enterica. This study aimed to produce experimental infection of Salmonella enterica serovars Panama and verifies the importance of the nose-to-nose contact in the transmission among weaned pigs. Six recently-weaned pigs were acquired from farm previously selected; free from Salmonella sp. Bacteriological analysis ruled out previous Salmonella sp contamination in all selected subjects. Isolations cabinets were used that provided the nose-to-nose contact and to eliminated the presence of other transmission routes and of outside contamination. Three groups were formed: control, sentinel and infected. The pigs of the control group and of the sentinel group, received, individually, orally sterile solution, while pigs of the infected group received solution containing 2,16 X 1010 CFU of Salmonella Panama. They were housed in the respective isolations cabinets and removed from it after 14 days, period in which samples of faeces were collected and submitted to daily analysis. The animals were necropsied and samples of tissues were collected. They were tested by bacteriological analysis, ELISA and serovars typification. There was systemic infection for Salmonella Panama in the animals of the infected group; however there was non transmission by nose-to-nose contact among weaned pigs, justifying the non isolation of the agent in the sentinel group at any moment. / Mestre

Displaced femoral neck fractures comprise more than a third of all hip fractures. There is controversy as to the optimal treatment. Despite attempts to improve the methods for internal fixation, complication rates have been almost unchanged: 20-40% non-union and late segmental collapse in another 10-20%. Internal fixation has been the preferred treatment in Scandinavia, whereas primary hemi- or total arthroplasty have been more prevalent in the rest of Europe and North America. In this study, patients 75 years or older, including those with mental impairment, were randomized to either internal fixation or cemented primary total hip arthroplasty (THA). A total of 146 hips in 143 patients were followed for two years. After one year 23% had died, and after two years 29%. Mortality was about the same in both groups. The accumulated mortality was pronounced among the mentally impaired patients. In the internal fixation group, 44% underwent further surgery. In the THA group, 18% dislocated. The dislocation rate was higher for the mentally impaired patients. The Harris hip scores were higher in the THA group, whereas pain was more common in the internal fixation group. The first 50 patients in each treatment group were studied concerning heterotopic ossification (HO), a well-known complication after THA. The incidence of HO in the THA group was similar to what is found after THA due to osteoarthritis. However, only 1/39 developed severe symptoms. A subgroup of 100 patients was included in a study concerning nutritional status and functional capacity using the Modified Norton scale, Katz index of ADL and a questionnaire measuring instrumental activities of daily living. The THA group fared better concerning weight change over time, locomotion and pain. The nutritional intervention did not show any measurable effects. All patients were followed until two years postoperatively and all fracturerelated hospital costs, including reoperations, were calculated. We found no difference in total costs between the treatment groups. Costs to the municipality were calculated comparing the baseline cost before surgery with the average cost per month during the first postoperative year. No difference was found between the treatment groups. On the basis of our results, we recommend arthroplasty for patients in this age group with normal mental function and high functional demands.

Syftet med denna systematiska litteraturstudie som inkluderar 18 artiklar, har varit att belysa vilka nutritionsstöd som kan förebygga och behandla malnutrition hos barn med cancer samt vilka omvårdnadsbehov som finns i samband med nutritionsbehandling. Resultatet visade att barn med cancer som behandlas med strålning och/eller cytostatika ofta drabbas av olika biverkningar som påverkar nutritionen. Cirka 46 % av barnen utvecklade malnutrition. Näringsintaget försämrades ofta på grund av biverkningarna vilket fick till följd att behandlingen försämrades samt tillväxt och utveckling påverkades negativt. Olika sätt fanns för att upprätthålla gott nutritionsstatus. Oralt intag förordades för att upprätthålla mag- tarmkanalens struktur och funktion. Alternativ för kostbehandling när barnet inte klarade att inta oral kost var nasogastrisk sond (NS), Perkutan Endoskopisk Gastrostomi (PEG) och Total Parenteral Nutrition (TPN). NS visade sig vara relativt biverkningsfritt och ett alternativ att tillgå under kortare nutritionsbehandlingar. PEG var ett gott alternativ med relativt få biverkningar då barnet behöver nutritionsstöd under längre tid. TPN var ett alternativ enbart då barnet inte kunde äta relaterat till bristande upptag i mag- tarmkanalen. Försämrat näringsintag påverkade barnets livskvalitet. Familjen påverkades genom att ätandet var en stark källa till konflikt mellan barnet och föräldrarna. Det var viktigt att barnet och familjen fick stöd i barnets förmåga att kunna äta samt att erbjudas näringsrik kost. Bedömning av nutritionsstatus och dokumentation av oralt intag, parenteralt intag och effekter av nutritionsbehandlingen var av stor vikt för att kunna ge barnet optimal omvårdnad.

Objetivos: O objetivo do presente estudo foi avaliar a dosagem da transferrina e pré-albumina séricas como marcadoras da resposta ao suporte nutricional em pacientes com câncer de esôfago. Métodos: Estudo clínico não-controlado com 45 pacientes internados com câncer de esôfago submetidos ao suporte nutricional antes de iniciar a terapia oncológica. De acordo com o estado nutricional, os pacientes receberam dieta por sonda nasoentérica, via oral ou combinada (via oral e sonda nasoentérica). O gasto energético basal foi estimado pela equação de Harris-Benedict. Pré-albumina e transferrina séricas foram dosadas antes e após o suporte nutricional. Valores de p < 0,05 foram considerados estatisticamente significativos. Resultados: A média do tempo de suporte nutricional foi de quatorze dias (±4,72). Houve aumento significativo dos níveis séricos de transferrina (p<0,001) e pré-albumina (p=0,002) após suporte nutricional. Aumento dos níveis de transferrina esteve associado com ingestão calórica (p=0,034), ao contrário dos níveis de préalbumina (p=0,864). Não houve relação estatisticamente significativa entre a ingestão de proteína com a variação dos níveis de transferrina (p=0,243) e préalbumina (p=0,913) do pré para o pós-suporte nutricional. Perda de peso na internação se correlacionou significativamente com os níveis de pré-albumina (- 0,545;p<0,001) e transferrina (r=-0,347;p=0,021). Houve associação estatisticamente significativa entre as variações da transferrina e pré-albumina do pré para o póssuporte nutricional (r=0,568; p<0,001). Conclusões: Houve um aumento significativo dos níveis séricos de préalbumina e transferrina após o suporte nutricional. Foi encontrada uma associação estatisticamente significativa entre as variações da transferrina e pré-albumina do pré para o pós-suporte nutricional. / Objectives: This study evaluated serum transferrin and prealbumin levels as markers of response to nutritional support in patients with esophageal cancer. Methods: Clinical, uncontrolled study with 45 hospitalized patients with esophageal cancer who received preoperative nutritional support. According to their nutritional status, patients received nasoenteric tube feeding, an oral diet, or a combined diet (oral and nasoenteric tube feeding. Resting energy expenditure were calculated using the Harris-Benedict equation. Serum prealbumin and transferrin levels were measured before and after nutritional support. P< 0.05 was considered statistically significant. Results: The mean nutritional support duration was 14 (±4.72) days. There was a significant increase in serum transferrin (P<0.001) and prealbumin (P=0.002) levels after nutritional support. The increase in transferrin levels (P=0.034), but not in prealbumin levels (P=0.861), was associated with calorie intake. There was no statistically significant difference between protein intake and variations in the levels of transferrin (P=0.243) and prealbumin (P=0.913) from pre- to post-nutritional support. Weight loss at admission was significantly associated with levels of prealbumin (r=- 0.545; P<0.001) and transferrin (r=-0.347; P=0.021). There was a statistically significant association between transferrin and prealbumin variations from pre- to post-nutritional support (r=0.568; P<0.001). Conclusions: There was a significant increase in serum transferrin and prealbumin levels after nutritional support. A significant association was found between serum transferrin and prealbumin variations.

Objetivos: O objetivo do presente estudo foi avaliar a dosagem da transferrina e pré-albumina séricas como marcadoras da resposta ao suporte nutricional em pacientes com câncer de esôfago. Métodos: Estudo clínico não-controlado com 45 pacientes internados com câncer de esôfago submetidos ao suporte nutricional antes de iniciar a terapia oncológica. De acordo com o estado nutricional, os pacientes receberam dieta por sonda nasoentérica, via oral ou combinada (via oral e sonda nasoentérica). O gasto energético basal foi estimado pela equação de Harris-Benedict. Pré-albumina e transferrina séricas foram dosadas antes e após o suporte nutricional. Valores de p < 0,05 foram considerados estatisticamente significativos. Resultados: A média do tempo de suporte nutricional foi de quatorze dias (±4,72). Houve aumento significativo dos níveis séricos de transferrina (p<0,001) e pré-albumina (p=0,002) após suporte nutricional. Aumento dos níveis de transferrina esteve associado com ingestão calórica (p=0,034), ao contrário dos níveis de préalbumina (p=0,864). Não houve relação estatisticamente significativa entre a ingestão de proteína com a variação dos níveis de transferrina (p=0,243) e préalbumina (p=0,913) do pré para o pós-suporte nutricional. Perda de peso na internação se correlacionou significativamente com os níveis de pré-albumina (- 0,545;p<0,001) e transferrina (r=-0,347;p=0,021). Houve associação estatisticamente significativa entre as variações da transferrina e pré-albumina do pré para o póssuporte nutricional (r=0,568; p<0,001). Conclusões: Houve um aumento significativo dos níveis séricos de préalbumina e transferrina após o suporte nutricional. Foi encontrada uma associação estatisticamente significativa entre as variações da transferrina e pré-albumina do pré para o pós-suporte nutricional. / Objectives: This study evaluated serum transferrin and prealbumin levels as markers of response to nutritional support in patients with esophageal cancer. Methods: Clinical, uncontrolled study with 45 hospitalized patients with esophageal cancer who received preoperative nutritional support. According to their nutritional status, patients received nasoenteric tube feeding, an oral diet, or a combined diet (oral and nasoenteric tube feeding. Resting energy expenditure were calculated using the Harris-Benedict equation. Serum prealbumin and transferrin levels were measured before and after nutritional support. P< 0.05 was considered statistically significant. Results: The mean nutritional support duration was 14 (±4.72) days. There was a significant increase in serum transferrin (P<0.001) and prealbumin (P=0.002) levels after nutritional support. The increase in transferrin levels (P=0.034), but not in prealbumin levels (P=0.861), was associated with calorie intake. There was no statistically significant difference between protein intake and variations in the levels of transferrin (P=0.243) and prealbumin (P=0.913) from pre- to post-nutritional support. Weight loss at admission was significantly associated with levels of prealbumin (r=- 0.545; P<0.001) and transferrin (r=-0.347; P=0.021). There was a statistically significant association between transferrin and prealbumin variations from pre- to post-nutritional support (r=0.568; P<0.001). Conclusions: There was a significant increase in serum transferrin and prealbumin levels after nutritional support. A significant association was found between serum transferrin and prealbumin variations.

Made available in DSpace on 2014-06-11T19:23:46Z (GMT). No. of bitstreams: 0 Previous issue date: 2008-02-19Bitstream added on 2014-06-13T19:50:57Z : No. of bitstreams: 1 oliveira_lg_me_jabo.pdf: 385808 bytes, checksum: 724ed5f57dfbaab664f6c58ba810c163 (MD5) / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) / A transmissão pela via fecal-oral é considerada o mais importante meio de disseminação de Salmonella sp. entre os suínos. Foi comprovada que a transmissão de Salmonella sp. através do contato naso-nasal entre suínos pode ser viável. Porém, alguns experimentos não conseguiram demonstrar tal transmissão em determinados sorotipos de Salmonella enterica. Este ensaio teve como objetivo produzir infecção experimental de Salmonella enterica subsp. enterica sorotipo Panama e verificar a importância da via nasonasal na transmissão entre leitões desmamados. Seis leitões recém-desmamados foram adquiridos de granja previamente selecionada, livre de Salmonella sp. Análises bacteriológicas confirmaram que todos os animais estavam livres de contaminação por Salmonella sp. Utilizaram-se baias isoladoras que proporcionavam o contato naso-nasal e eliminavam a possibilidade de outras vias de transmissão e de contaminação externa. Três grupos foram formados: controle, sentinela e infectados. Os leitões do grupo controle e do grupo sentinela receberam, individualmente, por via oral, solução estéril, enquanto que leitões do grupo infectado receberam inóculo contendo 2,16 X 1010 UFC de Salmonella Panama. Foram alojados nos isoladores respectivos e retirados depois de 14 dias, período no qual amostras de fezes eram colhidas e avaliadas diariamente. Os animais foram necropsiados e amostras de tecidos colhidas. Realizaram-se testes bacteriológicos, ELISA e sorotipificação. Houve infecção sistêmica por Salmonella Panama nos animais do grupo infectado, porém os resultados revelaram não haver a transmissão pela via naso-nasal entre leitões desmamados, pois em nenhum momento o agente foi isolado dos animais sentinelas. / The faecal-oral transmission is considering the most important route for transmission of Salmonella sp. between pigs. It has been proven that the Salmonella sp. transmission through the nose-to-nose contact among pigs can be viable. However, current data could not demonstrate such transmission in certain serovars of Salmonella enterica. This study aimed to produce experimental infection of Salmonella enterica serovars Panama and verifies the importance of the nose-to-nose contact in the transmission among weaned pigs. Six recently-weaned pigs were acquired from farm previously selected; free from Salmonella sp. Bacteriological analysis ruled out previous Salmonella sp contamination in all selected subjects. Isolations cabinets were used that provided the nose-to-nose contact and to eliminated the presence of other transmission routes and of outside contamination. Three groups were formed: control, sentinel and infected. The pigs of the control group and of the sentinel group, received, individually, orally sterile solution, while pigs of the infected group received solution containing 2,16 X 1010 CFU of Salmonella Panama. They were housed in the respective isolations cabinets and removed from it after 14 days, period in which samples of faeces were collected and submitted to daily analysis. The animals were necropsied and samples of tissues were collected. They were tested by bacteriological analysis, ELISA and serovars typification. There was systemic infection for Salmonella Panama in the animals of the infected group; however there was non transmission by nose-to-nose contact among weaned pigs, justifying the non isolation of the agent in the sentinel group at any moment.