Coordenação de Aperfeiçoamento de Pessoal de Nível Superior / The main goal of the present study is to assess and compare the data obtained from ventilometry, espirometry and vital signs of patients who undergoing DAPE under inhalation anesthesia, and its specific goal is to verify the existence of a co-relation between anesthetic and surgical procedure lengths and pulmonary volumes measured by ventilometry and espirometry during the DAPE post-operative period. The subjects were adult patients between 43,3 ± 13,4 years of age, being 8 males and 5 females admitted at the surgery clinic of the Federal University Hospital in Aracaju, Sergipe, Brazil, with a previous diagnosis of portal hypertension. It is a prospective study, with the data collection being carried out in two phases: pre-operative and post-operative stages. Researched variables: age; gender; heart rate (HR); respiratory frequency (RF); blood pressure (BP); partial oxygen saturation (PSO2); minute volume (MV); current volume (CV); forced expiratory volume in 1 second (FEV1); forced vital capacity (FVC); tifeneau index (FEV1/ FVC); surgery length; anesthesia length. The statistical analysis was performed by the Origin 6.2. software. To compare the averages of BP, HR, PSO2, MV, CV, FEV1, FVC and FEV1/ FVC in both pre and post-operative stages the T test Dependent or Paired Student test. To analyses the variance the Fisher test was applied. For the co-relation between anesthetic and surgical procedure length and MV, CV, FEV1 and FVC in the post-operative stage the Pearson simple linear co-relation test was applied. For statistical tests, a 95% (α=0,05) significance level was utilized. Results showed that there was a significant difference between the mean values of HR, RF, BP, MV, CV, FEV1, FVC and PSO2. There was no significant difference between the mean values of FEV1/ FVC. Reversely, the co-relation between surgery length and the pulmonary values measured on day 2 of the post-operative period was significant of strong aspect when compared to FEV1 and FVC, and suggested a non-significant co-relation in regular aspect when compared to MV and CV. Anesthesia length showed a significant co-relation in a strong aspect when compared to FEV1 and FVC, and suggested a non-significant co-relation of weak aspect when compared to MV and of regular aspect when compared to CV. It has been concluded that patients who have undergone portal hypertension surgery present significant reduction in MV, CV, FEV1, FVC and PSO2, in addition to a significant rise in HR, BP and RF when compared to the preoperational and day 2 of post-operative period. Moreover, a significant co-relation of strong aspect was detected when anesthetic and surgical procedure lengths were compared to post-operative FEV1 and FVC values. / A pesquisa teve como objetivos avaliar e comparar os dados fornecidos através dos sinais vitais, ventilometria e espirometria dos pacientes submetidos à DAPE sob anestesia geral, e verificar se existe correlação entre a duração anestésica e cirúrgica com os volumes pulmonares fornecidos pelos testes de função pulmonar. Foram avaliados pacientes adultos com idade média de 43,3 ± 13,4 anos, sendo 8 homens e 5 mulheres, admitidos na clínica cirúrgica do Hospital Universitário na cidade de Aracaju-SE, com diagnóstico prévio de hipertensão portal. Foi um estudo prospectivo, sendo a coleta de dados efetuada no pré e pósoperatório. Variáveis pesquisadas: idade; gênero; FC; FR; PA; SpO2; VM; VC; VEF1; CVF; VEF1/CVF; duração de cirurgia; duração da anestesia. A análise estatística foi efetuada através do programa estatístico Origin 6.2. Para comparação entre as médias da PA, FR, FC, SpO2, VM, VC, VEF1, CVF e VEF1/CVF no pré e pós-operatório foi aplicado o teste t de Student pareado ou dependente. Para análise das variâncias foi utilizado o teste de Fisher. Para correlação entre o tempo de anestesia e o tempo de cirurgia em relação ao VM, VC, VEF1 e CVF no pós-operatório foi aplicado o teste de correlação linear simples (correlação de Pearson). Foi utilizado um nível de significância de 95% (α=0,05). Os resultados mostraram que houve diferença significativa entre as médias da FC, FR, PA, VM, VC, VEF1, CVF e SpO2. Não houve diferença significativa entre as médias do VEF1/CVF e entre as variâncias. Já a correlação entre o tempo de cirurgia e os volumes pulmonares mensurados no 2° dia pós-operatório, mostrou-se significativa de aspecto forte quando comparado com o VEF1 e com o CVF, e sugeriu correlação não significativa de aspecto regular quando comparado com o VM e com o VC. O tempo de anestesia mostrou correlação significativa de aspecto forte quando comparado ao VEF1 e com o CVF, e sugeriu correlação não significativa de aspecto fraco quando comparado ao VM e de aspecto regular quando comparado ao VC. Concluímos que pacientes submetidos à cirurgia de hipertensão portal apresentam redução significativa do VM, VC, VEF1, CVF e SpO2, além de aumento significativo da FC, PAS e FR, quando comparadas as médias do pré e 2° dia pós-operatório. Houve correlação significativa quando comparadas duração anestésica e cirúrgica com o VEF1 e a CVF mensuradas no pós-operatório. .

A desconexão ázigo-portal e esplenectomia (DAPE) é a operação mais aceita e realizada em nosso meio para a profilaxia da recidiva hemorrágica por ruptura de varizes esofágicas ou gástricas em pacientes portadores de esquistossomose hepato-esplênica. Menores índices de ressangramento são obtidos através da associação da DAPE com escleroterapia ou ligadura elástica endoscópica das varizes esofágicas realizada no pós-operatório. Faltam trabalhos mostrando a evolução, a longo prazo, dos doentes esquistossomóticos submetidos a este tratamento. Este estudo retrospectivo tem como objetivo avaliar a evolução destes pacientes com tempo mínimo de seguimento de 5 anos. Foram analisados os prontuários dos pacientes operados no Serviço de Cirurgia de Fígado e Hipertensão Portal da Disciplina de Cirurgia do Aparelho Digestivo do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, no período compreendido entre março de 1989 a março de 2001 e que foram acompanhados prospectivamente. Avaliamos dados clínicos, laboratoriais, endoscópicos e ultra-sonográficos de 97 pacientes com seguimento de 116,4 ± 46,7 meses. Nenhum paciente cursou com insuficiência hepática clínica ou laboratorial. Ocorreu, no pós-operatório tardio, correção da anemia, leucopenia e plaquetopenia, diminuição dos níveis de bilirrubinas total e indireta séricas e aumento do tempo de atividade da protrombina. Houve significativa redução do número e calibre das varizes esofágicas, assim como da presença de sinais de manchas vermelhas e de varizes gástricas. Houve aumento na freqüência de gastropatia congestiva, entretanto, sem repercussão clínica significativa. A recidiva hemorrágica xviii ocorreu em 24,7% dos pacientes, sendo em 14,6% quando considerada apenas por varizes esofágicas, gástricas ou duodenais. A probabilidade estimada de não ocorrer ressangramento em 20 anos é de 67,1%, sendo de 82,5% quando considerada recidiva por varizes. Em quatro pacientes a recidiva hemorrágica ocorreu por varizes, mesmo após o relato, em exame endoscópico prévio, de erradicação das varizes esofágicas. À avaliação ultrassonográfica observou-se redução do calibre da veia porta no pósoperatório tardio, em comparação ao pré-operatório. Concluímos que a desconexão ázigo-portal com esplenectomia, associada ao tratamento endoscópico de varizes esofágicas no pós-operatório, propicia bons resultados do ponto de vista clínico com baixa morbidade e mortalidade; permite melhora laboratorial da função hepática e correção do hiperesplenismo; determina a redução da incidência dos sinais endoscópicos preditivos de sangramento digestivo por hipertensão portal (varizes esofágicas de grosso calibre, sinais de manchas vermelhas e varizes de fundo gástrico), porém, a gastropatia congestiva é mais freqüente; permite adequada profilaxia da recidiva hemorrágica em 67% dos pacientes ao longo de 20 anos. A recidiva hemorrágica por varizes pode ocorrer mesmo após a erradicação das varizes esofágicas, tanto por recidiva de varizes como por varizes de outro sítio (gástrica ou duodenal). Ocorre redução do calibre da veia porta no pós-operatório tardio, observado em exame ultrassonográfico em comparação ao pré-operatório. / Esophagogastric devascularization and splenectomy (EGDS) is nowadays the most performed operation for esophageal varices bleeding recurrence prophylaxis in hepatosplenic schistosomiasis. Lower rebleeding rates are obtained through the association of EGDS with postoperative endoscopic sclerotherapy or elastic bandage of esophageal varices, however, there is a lack of studies showing long term results. The objectives of this study were to evaluate retrospectively EGDS results in patients with at least five years of follow-up. Clinical, laboratorial, endoscopic and ultrasonographic data of 97 patients submitted to EGDS from March 1989 to March 2001 were analyzed. The mean follow-up was 116.4 months. There was no postoperative clinical or laboratorial hepatic insufficiency. In the late follow-up we observed normalization of preexisting anemia, leucopenia, thrombocytopenia, hyperbilirubinemia, and a prothrombin activity time increase. There was a significant esophageal varices caliber and number reduction, cherry red spots signs and gastric varices decrease. Congestive gastropathy was observed more frequently but without clinical importance. Bleeding recurrence occurred in 24.7% of the patients, however, in 14.6% when esophageal varices hemorrhage was considered. Estimated probability of rebleeding prophylaxis over 20 years is 67.1% and 82.5% when variceal recurrence was considered. Bleeding recurrence occurred in four patients even after endoscopic evaluation showing esophageal varices eradication. There was a significant portal vein caliber reduction on late ultrasound assessment, compared to preoperative. We concluded that the EGDS with postoperative endoscopic treatment leads to good clinical results with low morbidity and mortality; provides laboratorial liver function improve and xx hypersplenism correction; determines endoscopic predictive signs of portal hypertension digestive bleeding decrease (large esophageal varices, cherry red spots signs and gastric varices), however congestive gastropathy is more frequent; allows appropriate bleeding prophylaxis in 67% of the patients over 20 years. Variceal hemorrhagic recurrence may occur even when esophageal varices eradication is reached suggesting the need of an endoscopic surveillance even in this group of patients.

Made available in DSpace on 2015-04-11T13:57:05Z (GMT). No. of bitstreams: 1 cristiane.pdf: 3164331 bytes, checksum: 7898e5a4d4000f6f70a9d1bb95742f74 (MD5) Previous issue date: 2013-07-30 / Cyberjournalism in the Amazonas is the central theme of this work, from which we conducted a case study of the news portal d24am, in order to observe the product, processes and challenges faced by Rede Diário de Comunicação (RDC) for cyber news elaborate. Defends the production process as a definer of cyber news, starting from the initial stage of the agenda, calculation, writing, composing, editing stages to publishing and distribution of cyber news. To analyze this process is used theoreticalmethodological authors of Information Architecture (IA) in the evaluation of the journalistic product from the perspective of Organization, Labeling, Navigation and Search Systems proposed by Morville and Rosenfeld (2006), the research on the cyber news production process, emphasizing the preparation of the agenda and at the stage of formation (Schwingel, 2012), and, finally, to assess the potential use of the Internet in each of the three cyber news accompanied during the field survey (Zamith 2011). With this, there is the vital link between the production process cyber news from the specific case of portal d24am, and its constitution. The results of this research reveal that the news published on the portal d24am have few features cyber news, translated in reduced use of hypermedia narrative elements. This is because the model adopted by the integrated newsroom RDC is facing the productions of the printing press in the mold, without regard to the specifics of the production cyber news evaluated in this study. / Ciberjornalismo no Amazonas é o tema central deste trabalho, a partir do qual é realizado um estudo de caso do portal de notícias d24am, a fim de observar o produto, os processos e os desafios enfrentados pela equipe de Redação da Rede Diário de Comunicação (RDC) para elaborar cibernotícias. Defende-se o processo de produção como definidor da cibernotícia, partindo da etapa inicial de pauta, apuração, redação, composição, edição até as fases de publicação e distribuição das cibernotícias. Para analisar esse processo são utilizados aportes teórico-metodológicos de autores da Arquitetura da Informação (AI) na avaliação do produto jornalístico sob a ótica dos Sistemas de Organização, Rotulação, Navegação e Pesquisa de Rosenfeld e Morville (2006), a pesquisas acerca do processo de produção da cibernotícia, com ênfase da elaboração da pauta e na etapa de constituição (Schwingel, 2012), e, por fim, na avaliação do uso das potencialidades da Internet em cada uma das três cibernotícias acompanhadas durante a pesquisa de campo (Zamith, 2011). Com isso, observa-se a indispensável relação entre o processo produtivo da cibernotícia, a partir do caso específico do portal d24am, e a sua constituição. Os resultados desta pesquisa revelam que as notícias publicadas no portal d24am apresentam poucas características de cibernotícias, traduzidas no uso reduzido de elementos da narrativa hipermidiática. Isso ocorre porque o modelo de redação integrada adotado pela RDC está voltado para as produções aos moldes do jornal impresso, sem atentar para as especificidades da produção de cibernotícia avaliada no presente trabalho.

Submitted by Erika Demachki (erikademachki@gmail.com) on 2017-01-02T19:51:30Z No. of bitstreams: 2 Dissertação - Lorenna Dantas Lara - 2016.pdf: 3662954 bytes, checksum: 83564e362afcf091425a1c51a03c1047 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) / Approved for entry into archive by Luciana Ferreira (lucgeral@gmail.com) on 2017-01-03T09:57:13Z (GMT) No. of bitstreams: 2 Dissertação - Lorenna Dantas Lara - 2016.pdf: 3662954 bytes, checksum: 83564e362afcf091425a1c51a03c1047 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) / Made available in DSpace on 2017-01-03T09:57:13Z (GMT). No. of bitstreams: 2 Dissertação - Lorenna Dantas Lara - 2016.pdf: 3662954 bytes, checksum: 83564e362afcf091425a1c51a03c1047 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Previous issue date: 2016-09-29 / The need for transparency in government acts has been highly requested by the population that claims for an end to corruption in Brazil. The Brazilian public administration has been adopting regulatory practices, as well as transparency measures, to encourage social control since the Constitution of 1988. Public Transparency - which now takes place mainly through electronic portals exclusively focused on content for advertising management actions to public resources has been thoroughly studied and measured by many instances. This research aimed at devising, through thorough literature review of academic publishing in the area, an assessment model which featured elements of democracy, accountability, and transparency. The model was called TLS, for it takes theoretical, legal and social aspects into account in its assessments., A checklist parting from eight original models was obtained, with 109 assessment items divided into four dimensions, namely: content and overview; active transparency; usability and functionality and passive transparency. The model created was applied on the Goiás Transparente portal - the transparency portal of the Brazilan state of Goiás - and evaluated on a five-level scale, where the website has the third level of transparency. / A necessidade da transparência dos atos de governo vem sendo altamente requerida pela população que clama pelo fim da corrupção no Brasil. Desde a Constituição Federal de 1988, a administração pública vem adotando normativas e práticas de transparência para incentivar o controle social. A transparência pública – que hoje ocorre principalmente por meio de portais eletrônicos com conteúdo exclusivamente voltado para a publicidade das ações gestoras dos recursos públicos – vem sendo estudada e mensurada por vários atores. A partir de revisão literária em trabalhos científicos, legislação e manifestações da sociedade civil, buscou-se nesta pesquisa criar um modelo de avaliação que incorporasse elementos de democracia, accountability e transparência. O modelo foi denominada TLS por trazer a síntese de aspectos teóricos, legais e sociais em sua avaliação. A partir de oito modelos originais, chegou-se a um checklist com 109 itens avaliativos divididos em quatro dimensões, a saber: conteúdo e visão geral; transparência ativa; usabilidade e funcionalidade e transparência passiva. O modelo criada foi aplicada no portal Goiás Transparente – o portal de transparência do Estado de Goiás – e avaliou-se numa escala de cinco níveis, que o site possui o terceiro nível de transparência dentre os parametrizados.

Pesquisadores da área de Ciências Humanas da Universidade de São Paulo participaram de investigação sobre o uso do portal de periódicos CAPES Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, em que são referenciados artigos consagrados pelo meio científico do mundo inteiro. O objetivo foi contribuir com a geração de novos valores e conhecimentos, indicando dificuldades no acesso e divulgação da produção científica. Foi realizada uma pesquisa descritiva-exploratória que utilizou dados quantitativos extraídos de questionários. O trabalho mostra o processo de mudança na sociedade, causado pelas novas tecnologias, e a facilidade na obtenção de informações para o enriquecimento do debate acadêmico e para o progresso da ciência. / Researchers at the Human Sciences, University of São Paulo participated in study on the use of journal portal CAPES - Coordination for the Improvement of Higher Education, which are referenced by the scientific articles on the world. The objective was to contribute to the generation of new knowledge and values, indicating difficulties in access and dissemination of scientific production. We performed a descriptive and exploratory research that used quantitative data extracted from questionnaires. The work shows the process of change in society caused by new technologies, and ease in getting information to enrich the academic debate and the progress of science.

Submitted by Geandra Rodrigues (geandrar@gmail.com) on 2018-04-04T11:52:13Z No. of bitstreams: 1 silvanedeoliveirafrazao.pdf: 1459099 bytes, checksum: 715ddffeacd0ecf27b7bd72cca76f3b1 (MD5) / Approved for entry into archive by Adriana Oliveira (adriana.oliveira@ufjf.edu.br) on 2018-04-04T14:56:10Z (GMT) No. of bitstreams: 1 silvanedeoliveirafrazao.pdf: 1459099 bytes, checksum: 715ddffeacd0ecf27b7bd72cca76f3b1 (MD5) / Made available in DSpace on 2018-04-04T14:56:10Z (GMT). No. of bitstreams: 1 silvanedeoliveirafrazao.pdf: 1459099 bytes, checksum: 715ddffeacd0ecf27b7bd72cca76f3b1 (MD5) Previous issue date: 2017-07-31 / PROQUALI (UFJF) / Analisa a contribuição do Portal de Periódicos da CAPES para a produção científica dos docentes permanentes dos Programas de Pós-Graduação em Farmácia no triênio 2010-2012. A área de saúde é um campo que vem se expandindo em termos de pesquisa e a opção de estudar a subárea de Farmácia se deu por existirem poucos estudos na área, sobretudo pesquisas sobre o Portal de Periódicos da CAPES, principalmente com foco em avaliação de coleções. A metodologia empregada foi a pesquisa documental, com análise descritiva e abordagem quantitativa, utilizando técnicas bibliométricas. A população estudada foi os docentes permanentes vinculados aos Programas de Pós-Graduação (PPGs) em Farmácia reconhecidos pela CAPES. Dos 63 PPGs na área de Farmácia identificados durante o período especificado, selecionaram-se os sete Programas com conceitos seis e sete na classificação da CAPES, por considerar que a produção científica no âmbito desses programas apresentaria tendências mais expressivas de uso dos recursos bibliográficos estrangeiros disponibilizados pelo Portal. Entre os anos de 2010 e 2012, verificou-se que esses sete Programas possuíam um quadro de docentes permanentes composto por 127 pesquisadores, os quais publicaram um total de 1387 artigos em 553 periódicos estrangeiros. Quanto à coleção oferecida pelo Portal, observou-se uma redução de vinte e um títulos entre 2015 e 2017, correspondentes a 0,17%. Com relação à contribuição do Portal para a produção científica da área, constatou-se que 84,45% dos títulos nos quais os docentes da área publicam suas pesquisas são cobertos pelo Portal. Concluiu-se que o Portal apresenta uma contribuição significativa para os pesquisadores da área de Farmácia. / It analyzes the contribution of the CAPES Journals Portal for the scientific production of the permanent faculty of the Postgraduate Programs in Pharmacy in the 2010-2012 triennium. The area of health is a field that has been expanding in terms of research and the option of studying the Pharmacy subarea was because there are few researches in the area, mainly researches about the CAPES Journals Portal, principally focusing on evaluation of collections. The methodology used was the documentary research, with descriptive analysis and quantitative approach, utilizing bibliometric techniques. The population studied were the permanent faculty linked to the Postgraduate Programs (PPGs) in Pharmacy recognized by CAPES. Of the 63 PPGs in the Pharmacy area identified during the specified period, seven Programs with concepts 6 and 7 in the CAPES classification were selected, considering that the scientific production in the ambit of those programs would present more expressive tendencies of use of the foreign bibliographic resources available in the Portal. Between 2010 and 2012, it was found that those seven Programs had a permanent faculty table composed of 127 researchers, who published a total of 1387 articles in 553 foreign journals. As for the collection offered by the Portal, it was observed a reduction of twenty one titles between 2015 and 2017, corresponding to 0.17%. Regarding to the contribution of the Portal to the scientific production of the area, it was found that 84.45% of the titles in which the faculty of the area publish their researches are covered by the Portal. It was concluded that the Portal presents a significant contribution for the researchers of the Pharmacy area.

Orientador: Gabriel Hessel / Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas / Made available in DSpace on 2018-08-20T13:44:33Z (GMT). No. of bitstreams: 1 Alcantara_RobertaVacaride_D.pdf: 665519 bytes, checksum: b1cdfc8920d36cc06cf754f99e2c24af (MD5) Previous issue date: 2012 / Resumo: Objetivo: Identificar preditores não invasivos de varizes esofágicas em crianças e adolescentes com hepatopatia crônica e obstrução extra-hepática da veia porta (OEHVP). Casuística e métodos: Estudo prospectivo que incluiu 53 crianças e adolescentes com hepatopatia crônica ou OEHVP, sem antecedente de hemorragia digestiva ou tratamento de varizes esofágicas (VE), com até 20 anos de idade. Dois grupos foram formados: grupo I (35 pacientes com hepatopatia crônica) e grupo II (18 com OEHVP). Foram realizados hemograma, RNI, albumina, bilirrubina total, ultrassonografia de abdome e endoscopia digestiva alta. O índice esplênico (IE) foi determinado dividindo a dimensão longitudinal do baço pelo limite superior dos valores de referência da literatura. As variáveis foram comparadas quanto à presença ou não de VE, varizes gástricas (VG) e gastropatia da hipertensão portal (GHP) através de análise univariada (? ², exato de Fischer e Wilcoxon) e multivariada (regressão logística). A acurácia foi determinada a partir da área sob a curva ROC. Resultados: As VE foram observadas em 48,5% dos pacientes do grupo I e em 83,3% do grupo II. Plaquetopenia (p=0,0015), esplenomegalia (p=0,0003), razão plaquetas/IE (p=0,0007), presença de shunt esplenorrenal (p=0,0329) e a espessura do ligamento venoso (p=0,0151) se mostraram indicadores preditivos de VE entre os pacientes do grupo I. Após análise multivariada, a plaquetopenia (odds=21,7) se manteve um indicador independente da presença de VE entre os pacientes com hepatopatia crônica. Entre os pacientes do grupo II observou-se diferença estatística quanto à presença de varizes na vesícula (p=0,0245) e espessura da parede da vesícula biliar (p=0,0289). O número de plaquetas (p=0,0369), o IE (p=0,0041) e a razão plaquetas/IE (p=0,0192) se mostraram indicativos de VG entre os pacientes do grupo I. A presença de plaquetopenia foi maior entre os pacientes do grupo II com VG (p=0,0216). GHP foi estatisticamente maior entre os pacientes do grupo I com plaquetopenia (p=0,0286), presença de shunt esplenorrenal (p=0,0384), menor razão plaquetas/IE (p=0,0369) e maior espessura do ligamento venoso (p=0,0226). Conclusões: O número de plaquetas, o índice esplênico, a razão plaquetas/IE, a presença de shunt esplenorrenal e a espessura do ligamento venoso foram indicativos de VE entre os pacientes com hepatopatia crônica. A presença de varizes na vesícula e maior espessura da parede da vesícula foram indicativos de VE entre os pacientes com OEHVP. Plaquetopenia, esplenomegalia e menor razão plaquetas/IE foram indicativos de VG entre os pacientes do grupo I. Plaquetopenia foi indicativa de VG entre os pacientes do grupo II. Plaquetopenia, presença de shunt esplenorrenal, RNI alargado, menor razão plaquetas/IE e maior espessura do ligamento venoso foram indicativos de GHP entre os pacientes com hepatopatia crônica / Abstract: Aim: Identify non-invasive predictors of esophageal varices in children and adolescents with chronic liver disease and extra hepatic portal venous obstruction (EHPVO). Casuistic and methods: Prospective evaluation of 53 patients younger than 20 with chronic liver disease or EHPVO and no history of bleeding or prophylactic treatment of esophageal varices (EV). They were divided in 2 groups: group I (35 with chronic liver disease) and group II (18 with EHPVO). Their blood count, INR, albumin, bilirubin, abdominal ultrasound and upper endoscopy results were taken. A splenic index (SI) was determined by dividing the patients' spleen dimension by its uppermost limit according to their age. The variables were compared to the presence of EV, gastric varices (GV) and portal hypertensive gastropathy (PHG). The univariate (?² test, Fischer's exact test and Wilcoxon rank sum test) and multivariate (logistic regression) analysis were performed. A ROC curve was constructed and the area under the ROC was calculated. Results: EV were observed in 48,5% of group I patients and in 83,3% of group II patients. Low platelet count (p=0,0015), splenomegaly (p=0,0003), SI (p=0,0007), splenorenal shunt (p=0,0329) and lesser omental thickness (p=0,0151) were statistically predictors of EV among group I patients. The multivariate analysis showed low platelet count (odds=21,7) as an independent predictor of EV in patients with chronic liver disease. Gallbladder varices (p=0,0245) and gallbladders' wall thickness (p=0,0289) statistically predicted EV among group II patients. Platelet count (p=0369), SI (p=0,0041) and platelet/SI ratio (p=0192) were significant predictors of GV among group I patients. Low platelet count predicted GV among group II patients (p=0,0216). PHG occurred more often among group I patients who had low platelet count (p=0,0286), splenorenal shunt (p=0,0384), lower platelet/SI ratio (p=0,0369) and thicker lesser omental thickness (p=0,0226). Conclusions: Platelet count, splenic index, platelet/SI ratio, splenorrenal shunt and lesser omental thickness were indicative of EV among children and adolescents with chronic liver disease. Gallbladder varices and thicker gallbladders' wall were indicative of EV among EHPVO patients. Low platelet count, splenomegaly and lesser platelet/SI ratio were indicative of GV among group I patients. Low platelet count was indicative of GV among group II patients. Low platelet count, splenorenal shunt, bigger INR, lesser platelet/SI ratio and thicker lesser omentum were indicative of PHG among chronic liver disease patients / Doutorado / Pediatria / Doutor em Saude da Criança e do Adolescente

This diploma thesis concerns enterprise portals and its objective is to map their functional support, which they can bring to the company. Especially to the access integrationarea. To achieve this goal the following proces was selected: The first step was to create theoretical background which describes the area of enterprise portals and how it can be seen. In the following part were set main functional areas whose coverage may be assured by the enterprise portal. These areas are : presentation, personalization and customization, security, administration, content management system, search, collaboration, accessibility and portlets. Another part is focused on the selection of specific portal solutions which are evaluated and compared at the conclusion. These are chosen products : IBM WebSphere Portal, Microsoft Sharepoint Server 2007, Oracle Portal 10g, BEA WebLogic Portal. Personal benefit is particularly comprehensive look into the issue of enterprise portals. Theoretical background makes possible to quickly obtain information which are presented in a logically organizace form. It will ensure continuity in the knowledge absorption. Practical part offers look into the enterprise portal market situation and shows what can offer specific product and at what level.

This diploma thesis concerns enterprise portals and its objective is to map their functional support, which they can bring to the company. Especially to the access integration area. To achieve this goal the following proces was selected: The first step was to create theoretical background which describes the area of enterprise portals and how it can be seen. In the following part were set main functional areas whose coverage may be assured by the enterprise portal. These areas are : presentation, personalization and customization, security, administration, content management system, search, collaboration, accessibility and portlets. Another part is focused on the selection of specific portal solutions which are evaluated and comared at the conclusion. These are chosen products : IBM WebSphere Portal, Microsoft Sharepoint Server 2007, Oracle Portal 10g, BEA WebLogic Portal. Personal benefit is particularly comprehensive look into the issue of enterprise portals. Theoretical background makes possible to quickly obtain information which are presented in a logically organizace form. It will ensure continuity in the knowledge absorption. Practical part offers look into the enterprise portal market situation and shows what can offer specific product and at what level.

Since the 1980’s, education had to face various challenges such as new technologies, new ways of information gathering but also a reconsideration of conventional educational approaches. As a result, more emphasis has been placed on laboratory work in school science. In many industry nations, this trend was likewise bolstered by unexpected poor results in international comparative assessments (e.g. PISA, TIMSS), as well as students’ poor perception of science and, in relation to that, negative effects on career choices. To combat this growing trend, in Germany many out-of-school science laboratories were established in the recent years to foster interest in science. However, despite their positive temporary effects, approaches to increase effects or to develop long term positive changes are in demand. This research investigates how the out-of-school laboratory effects are affected by a preparation and post enhancement based upon previous studies. Therefore, an online portal was developed which provided cognitive and affective content in order to prepare and post enhance students for their visit in an out-of-school laboratory. The research-based study was aimed at students from grade 10 of lower and upper secondary level who perform one-day experimental activities at the out-of-school laboratory located at the Helmholtz-Zentrum Dresden-Rossendorf research center. In doing so, a comparative analysis was conducted between students who used the online portal and control group members who just regularly visited the laboratory without a special preparation or post enhancement. The evaluation follows a pre, post, and follow-up approach. Based on the results of this research, it could be confirmed that the online portal, as a tool to prepare and post enhance students, had a significant impact. Moreso, students’ situational interest was positively promoted through the online portal. This also applied for related features, like students’ self-concept as well as their perceptions of the out-of-school laboratory environment and even slight effects on their individual interest. As it turned out regarding the desired situational interest, females benefitted most. However, again most results suggest that evoked effects diminish over time. Even though this likely can be traced back to the characteristics of the post enhancement of the online portal, outcomes regarding students’ interest in science and a career in physics indicate the post enhancement’s ability to ensure sustainability. Within the sample three classes were identified based on their interests. Accordingly, for all classes’ members the portal fosters their situational interest. This especially applies for less scientific interested students. Assessments on the portal’s perception by the students revealed a high degree of willingness to prepare for the laboratory visit and to spend the time required. A large majority appreciated the online portal for their laboratory work. An extended preparation, like presented in this study, is still regarded as acceptable to the students. Nevertheless, a compulsory preparation and post enhancement is highly recommended. On the whole, it can be concluded that the online portal respectively a preparation and post enhancement is beneficial for activities out-of-school. / Anfang der 1980er-Jahre ergaben sich im Bildungssektor eine Reihe von Herausforderungen, die im Zusammenhang mit neuen Technologien, neuen Wegen des Informationsaustausches, aber auch des Hinterfragens traditioneller Bildungsansätze standen. Im Ergebnis dessen kam der experimentellen Arbeit im naturwissenschaftlichen Unterricht eine stärkere Rolle zu. Unerwartet schwache Ergebnisse internationaler Vergleichsstudien (z.B. PISA, TIMSS) sowie ein schlechtes Image der Naturwissenschaften und damit einhergehende negative Auswirkungen auf die Kurs- und Berufswahl verstärkten diesen Trend in vielen Industrienationen. Vor diesem Hintergrund und mit dem Ziel, Interesse an Naturwissenschaften zu fördern, wurden in Deutschland in den vergangenen Jahren zahlreiche Schülerlabore etabliert. Trotz der Tatsache, dass die Einrichtungen positive Effekte erzielen, sind diese teilweise gering oder schwächen mit der Zeit ab. Wie bisherige Studien vermuten lassen, scheint die Vor- und Nachbereitung von Veranstaltungen im Schülerlabor eine Lösung hierfür zu bieten. Anhand der vorgestellten Studie soll dies untersucht werden. In diesem Zusammenhang wurde ein Online-Portal für Schülerinnen und Schüler entwickelt. Basierend auf kognitiven und affektiven Inhalten bietet es Teilnehmern die Möglichkeit, ihren Schülerlaborbesuch vor- und nachzubereiten. Die Studie richtete sich an Schüler ab der 10. Klasse der Sekundarstufe 1 und 2, die einen Experimentiertag im Schülerlabor DeltaX am Helmholtz-Zentrum Dresden-Rossendorf absolvierten. Dabei wurden in Form einer Vergleichsstudie Teilnehmer mit und ohne Nutzung des Online-Portals gegenübergestellt. Die entsprechenden Daten der Untersuchung wurden durch eine Fragebogenerhebung im Pre-Post-Follow-up-Design erhoben. Die Ergebnisse der Studie bestätigen den signifikanten Einfluss des Online-Portals. So zeigen sich durchaus positive Effekte hinsichtlich der Entwicklung des aktuellen Interesses der Schülerinnen und Schüler. Gleiches gilt auch im Hinblick auf verwandte Konstrukte wie das Fähigkeitsselbstkonzept, die wahrgenommenen Merkmale der Laborumgebung und auch abgeschwächt für dispositionale Interessen. Bezogen auf die angestrebte Förderung des aktuellen Interesses zeigte sich, dass vor allem Schülerinnen profitieren. Allerdings ließ sich für die meisten der hervorgerufenen Effekte ein Absinken im Verlauf der Zeit erkennen. Möglicherweise ist das auf die Umsetzung der Nachbereitung im Rahmen des Online-Portals zurückzuführen. Die Ergebnisse lassen die Vermutung zu, dass die Nachbereitung bezüglich des Interesses an Naturwissenschaften und an einem physikalischen Beruf das Potenzial besitzt, mehr Nachhaltigkeit hervorzurufen. Um Vorinteressen der Teilnehmer zu berücksichtigen, konnten drei unterschiedliche naturwissenschaftliche Interessensklassen identifiziert werden. Es stellte sich heraus, dass die Entwicklung des aktuellen Interesses aller drei Interessenklassen durch das Online-Portal gefördert wird. Dies gilt vor allem für die gering naturwissenschaftlich interessierten Schülerinnen und Schüler. Untersuchungen, die sich auf das Online-Portal selbst bezogen, offenbarten zum einen ein hohes Maß an Bereitschaft, sich auch mit dem dafür notwendigen zeitlichen Aufwand auf den Experimentiertag im Schülerlabor vorzubereiten. Zum anderen schätzt die breite Mehrheit der Teilnehmer das Online-Portal für ihre Arbeit im Schülerlabor. Selbst eine umfangreichere Vorbereitung wird von den Schülerinnen und Schülern als akzeptabel betrachtet. Es wird dennoch dazu geraten, die Vor- und Nachbereitung obligatorisch durchzuführen. Insgesamt zeigen die Ergebnisse dieser Studie den positiven Einfluss des Online-Portals bzw. der Vor- und Nachbereitung auf außerschulische Aktivitäten.