The objective of this study was to explore a possible association between infant mortality rate (IMR) and Medicaid dental benefit payouts per state, as well as propose an expansion of the dental benefits provided through Medicaid. Data was obtained from the Vital Statistics report 2012 and the Center for Medicare & Medicaid Services (CMS) Medicaid coverage database for fiscal year 2011. Population and demographic data was also collected for further comparison. The states observed were Alabama, Georgia, Kentucky, Louisiana, North Carolina, South Carolina, and Tennessee. The IMR data was ranked in ascending order and then the dental payments were compared between the seven southern states. There did not appear to be an association between the two variables. It was hypothesized that the state with the highest IMR would have the least amount of Medicaid dental payments; possibly indicating limited benefits and a need for expansion. The data did not support the hypothesis. Although Mississippi had the highest IMR at 9.9 per 1,000 live births, the amount dental benefits paid through Medicaid was not the lowest. Kentucky had the lowest IMR at 6.9 per 1,000 live births, and North Carolina had the highest amount of dental payments with $352,602 being paid by the state. However, the comparing variable in each state did not reflect an association. Limitations of the study were addressed and suggested improvements were made for future studies that would possibly yield significant findings. In conclusion, the data collected and observed did not provide evidence that the expansion of Medicaid dental benefits would combat infant mortality rates across the country.

Introduction: Many medications have an unproven safety profile for use during pregnancy, leading to issues when chronic diseases, such as hypertension and depression, present during pregnancy. The focus of this research programme is to determine whether in utero exposure to antihypertensive and antidepressant medication is associated with increased risk of adverse events at birth, and up to 27 months of age in the child. Methods: Two systematic reviews were performed to identify current published literature and knowledge gaps. Following this, using Scottish healthcare data, a cohort of 268,711 children born 2010-2014 were identified. Following cleaning of the data, multiple imputation was used to account for missing values. Poisson, linear and multinomial regressions were performed to identify the relationship between in utero medication exposure and child outcomes. Results: In utero antihypertensive exposure was associated with preterm birth, low birth weight, small for gestational age, but not developmental issues. However, untreated hypertension was associated with low birth weight, preterm birth, and small for gestational age. In utero antidepressant exposure was associated with preterm birth, low birth weight, small for gestational age, preeclampsia, having a special needs indicator at 10 days and 6-8 weeks post-birth, developmental issues at 27 months Conclusions: This research programme identified several adverse outcomes following in utero exposure to antihypertensive and antidepressant medication.

Objetivo: Investigar a associação entre ingestão materna de cafeína durante o período gestacional e as medidas antropométricas de crianças aos três e seis meses de vida. Métodos: Estudo observacional longitudinal, utilizando uma amostra de conveniência de duplas mãe-filho divididos em cinco grupos: gestantes diabéticas (DM), hipertensas (HAS), tabagistas (TAB), que tiveram filhos pequenos para idade gestacional (PIG) e um grupo controle (CTL). A amostra foi selecionada em três hospitais de Porto Alegre, capital do Rio Grande do Sul, no período de 2011 a 2015. Avaliou-se a ingestão materna de cafeína na gestação por Questionário de Frequência Alimentar (QFA) realizado no sétimo dia pós-parto. Os recém-nascidos foram avaliados ao nascimento, aos três e seis meses. As medidas antropométricas utilizadas foram peso, comprimento e dobras cutâneas (DC). As análises foram realizadas por regressão linear. Resultados: A amostra foi composta por 272 duplas mãe-filho: 41 DM, 26 HAS, 68 TAB, 25 PIG e 112 CTL. Não houve diferença em peso e comprimento dos filhos de consumidoras e não consumidoras de cafeína (p>0,05). As crianças do grupo DM tiveram a maior média ajustada para DC aos três meses de idade. Houve interação entre o consumo de cafeína na gestação e a soma das DC das crianças aos três meses de idade para os grupos DM e CTL (p<0,05). A diferença da média ajustada das DC e a interação delas com o consumo de cafeína não foram observadas aos seis meses. Conclusões: O consumo materno de cafeína influenciou nos valores de DC aos três meses de idade, diminuindo-as para as crianças do grupo DM e aumentando-as no grupo CTL. / Objective: To investigate the association between maternal caffeine intake during pregnancy and anthropometric measures of infant at three and six months. Methods: A longitudinal observational study using the mother-child pairs in convenience sample divided into five groups of pregnant women: diabetic (DM), hypertensive (HYP), smokers (SMO), who had small children for gestational age (SGA) and a control group (CTL). Researchers selected the sample in three public hospitals in Porto Alegre, South of Brazil, in the period from 2011 to 2015. Food Frequency Questionnaire (FFQ) evaluated the maternal caffeine intake during pregnancy on the seventh day postpartum. Anthropometric measures used were weight, length, and skinfold thickness (SK). They assessed at birth, at three and six months of child. Linear regression was used to analyze the interaction between caffeine intake and SK. Results: We investigated 272 mother-child pairs: 41 DM, 26 HYP, 68 SMO 25 SGA and 112 CTL. There were no differences in children’s anthropometric measures of mothers consuming and not consuming caffeine (P >0.05). Children of DM group had the highest adjusted average for skinfolds at 3 months. There was interaction between caffeine consumption during pregnancy and the sum of SK of children at 3 months for DM and CTL groups (P <0.05). The difference between adjusted means for SKs infant and caffeine consumption by pregnant women were not observed at six months. Conclusions: Maternal caffeine intake influenced values of SKs at 3 months of age, reducing to the children of the DM group and increasing in the CTL group.

Introdução: O conhecimento sobre nevos na gestação é escasso. Existem relatos de crescimento e mudança no padrão dermatoscópico, com formação de novas estruturas e alterações de pigmentação e da arquitetura da rede pigmentar. A maioria dos estudos nesta área são relatos de caso e estudos prospectivos em que foram avaliados poucos nevos por gestante. Objetivo: Analisar mudanças no mapeamento corporal de gestantes e nas estruturas dermatoscópicas dos nevos melanocíticos destas pacientes. Método: Foram avaliados um total de 703 nevos melanocíticos provenientes de 18 gestantes, no primeiro e terceiro trimestres. Foi realizado exame de mapeamento corporal total e dermatoscopia digital e as imagens foram comparadas em relação à formação de novas lesões; mudanças nas estruturas dermatoscópicas (crescimento, mudanças pigmentares, padrão pigmentar, mudanças de rede pigmentar, glóbulos e pontos, novas áreas estruturas vasculares, novas estrias, novas áreas sem estruturas); associação de crescimento de nevos com relação à localização, ao fototipo, ao risco de melanoma, às estruturas dermatoscópicas e à faixa etária; e associação de fototipo e risco de melanoma com estruturas dermatoscópicas. Resultados: Na comparação das imagens do mapeamento corporal, tiveram 44% de pacientes com novas lesões, variando de 1 a 5 lesões por paciente. Todas as pacientes com novas lesões tiveram pelo menos uma das lesões localizada nos membros superiores. Com relação à avaliação dos 703 nevos melanocíticos, 10.4% tiveram hiperpigmentação e 5.8% tiveram hipopigmentação. As mudanças nas estrtuturas dermatoscópicas foram: 23% de mudanças de rede pigmentar, 3.2% de formação de novos vasos, 1.7% de novas estrias, 1% de novas áreas sem estruturas e 55% de crescimento de nevos. Os nevos que cresceram se localizavam com maior frequencia no abdômen (87.1%; p < 0.001), foram mais frequentes nas pacientes que tinham maior risco de melanoma (45% ; p = 0.019), tiveram mais mudanças de rede pigmentar (27.1% ; p = 0.014) e maior formação de glóbulos/pontos (16% ; p < 0.001). Houve uma associação entre formação de estrias e fototipo (p = 0.012), sendo mais frequente nos fototipos II (2.7%), se comparados com fototipos III (1.3%) e IV (0%). Conclusão: Novos nevos melanocíticos podem aparecer na gestante, especialmente nos membros. Um parcela dos nevos pré-existentes se altera na gestação. Crescimento dos nevos parecem ocorrer mais frequentemente em pacientes de alto risco para desenvolver melanoma. O aparecimento de novas estrias é mais frequente em fototipos mais baixos. / Background: Melanocytic nevi might vary in size and number in pregnant women and the differential diagnosis with melanoma may be challenging. Dermoscopy improves the accuracy of pigmented lesions evaluation. Little is known about the dermoscopic changes in melanocytic nevi during pregnancy. Objectives: This study aims to describe changes in total body photography of pregnant women and dermoscopy aspects of their melanocytic nevi. Methods: A total of 703 melanocytic nevi were evaluated from 18 pregnant women, in the first and in the third trimester of gestation. Total body photography and digital dermoscopy were made and the images obtained from the first and third trimesters were compared for new lesions formation; changes in dermoscopic aspects (enlargement, pigmentation changes, pigmentation pattern, network changes, globules and dots, new vascular structures, new streaks, new structureless area); association of nevi enlargement with body location, skin type, risk melanoma, dermoscopy structures and age group; and association of skin type and risk of melanoma with dermoscopy structures. Results: When comparing the total body photography, there were 44% of patients with new lesions, ranging from 1 to 5 new lesions per patient. All patients with new lesions presented at least one of them on the upper limbs. Regarding dermoscopic evaluation of the 703 melanocytic nevi, 10.4% had hyperpigmentation and 5.8% had hypopigmentation. Regarding the dermoscopic structures, there were 23% of network changes, 12.4% new globules/dots, 3.2% of new vessels formation, 1.7% of new streaks, 1.0% of new structureless area, and 55.0% nevi increased in size when comparing the first and third trimesters. These lesions that increased in size were more likely to be seen in the abdomen (87.1%; p<0.001), were more frequent in patients with high risk of melanoma (45.0% ; p=0.019), had more network changes (27.1% ; p=0.014) and new globules and dots formation (16.0% ; p<0.001). An association between streaks formation and skin type was significant (p=0.012) and was more frequent in skin type II (2.7%), when compared to skin type III (1.3%) and IV (0%). Conclusions: New melanocytic nevi may occur in pregnant women, especially on the limbs. A portion of the pre-existing melanocytic nevi changes in pregnancy. Nevi enlargement seem to occur more frequently in high risk melanoma patients. Appearance of new streaks are more frequent in fair skin types.

Orientador: Maria Terezinha Serrão Peraçoli / Banca: José Carlos Peraçoli / Banca: Joélcio Francisco Abbade / Banca: Nilton Hideto Takiuti / Resumo: Silibinina é um flavonóide quimicamente definido e o principal componente ativo da silimarina, um complexo polifenólico obtido de frutos e sementes de Silybum marianum, que possui propriedades anti-inflamatória, hepatoprotetora e anti-carcinogênica. Objetivo: O objetivo deste trabalho foi avaliar os efeitos da silibinina sobre a performance reprodutiva de ratas prenhes Wistar e as anomalias e/ou malformações de seus fetos. Métodos: Foram utilizadas ratas Wistar prenhes estratificadas em quatro grupos experimentais: controle (n = 6), ratas tratadas com 50mg/kg/dia de silibinina (Grupo I, n = 6), ratas tratadas com 100mg/kg/dia de silibinina (Grupo II, n = 6) e ratas tratadas com 200mg/kg/dia de silibinina (Grupo III, n = 6). Os animais receberam tratamento por via oral (gavage). Durante toda a prenhez, o consumo de ração e a ingestão de água, bem como o ganho de peso corporal foram avaliados. No dia 21 de prenhez as ratas foram anestesiadas A cesárea foi realizada no 21º dia, quando os recém-nascidos foram mortos e processados para análise das variações e/ou malformações. Resultados: os grupos controle e tratados não apresentaram diferenças significativas em relação aos parâmetros fetais, não se observando sinais de toxicidade materna com as diferentes concentrações de silibinina empregadas. Conclusão: O tratamento com silibinina não determinou efeitos deletérios na performance reprodutiva das ratas, mesmo quando utilizada em altas doses (200 mg/Kg/dia). / Abstract: Silibinin is a chemically defined flavonoid and the main active component of silymarin, a polyphenolic complex from fruits and seeds of Silybum marianum, which has anti-inflammatory, hepatoprotective and anticarcinogenic properties. Objective: The aim of the present study was to evaluate the dose-dependent effect of silibinin treatment on maternal reproductive performance and on abnormalities and/or fetal malformations. Methods: Pregnant Wistar rats were distributed in four experimental groups: control, not treated with silibinin (n=6), rats treated with silibinin 50mg/kg/day (Group I, n = 6), rats treated with silibinin 100mg/kg/day (Group II, n = 6) and rats treated with silibinin 200mg/kg/day (Group III, n = 6). Silibinin was administrated by gavage from day 0 to 20 of pregnancy. During the period of pregnancy food and water intake, as well as weight gain were evaluated. On day 21 of pregnancy, the rats were anesthetized and submitted to cesarean section to analyse maternal reproductive performance and fetal malformations. Results: The control and silibinin-treated groups did not show significant differences in relation to the fetal parameters evaluated and no maternal toxicity effects of silibinin were detected in the concentrations employed. Conclusion: Silibinin treatment did not determined deleterious effect on the maternal reproductive performance and fetal outcome even when employed in high dose (200 mg/Kg). / Mestre

Forty years ago, when an American woman wanted to know if she was pregnant, she made an appointment with a medical professional who would conduct a pregnancy test and tell her the result. Propelled by the medical establishment’s control, surveillance, and neglect of women’s health, the women’s health movement of the 1970s sought to put women’s health “into their own hands.” Encouraged in part by the rhetoric of the women’s health movement, pregnancy tests became available for purchase over-the-counter, without a prescription, and outside of the control of the medical establishment. This dissertation examines this passage of the pregnancy test from the hands of medical professionals to the hands of lay people and asks, has the pregnancy test really delivered on its promise to give women information, choice, and control? We think of women’s reproductive health tools in the hands of doctors as oppressive and in the hands of women as liberating; the central argument of this dissertation is that this view is naïve. Putting the informational power about women’s bodies into a mobile diagnostic technology did not change the nature of the beast. Through this examination of the pregnancy test in American life, we can trace the flow of reproductive power through various people, places, and things to better understand the character of women’s subordination.

This dissertation examines associations between unintended pregnancy and future maternal mental health and parenting behaviors. Put simply, I examine whether a mother who self-reports her pregnancy as being unintended at her child’s birth will have longstanding differences in mental health and parenting behaviors as her child ages. Drawing on two separate sources of data, I examine these associations taking into account three different ways of measuring unintended pregnancy. Drawing on the Fragile Families and Child Wellbeing Study (FFCWS), unintended pregnancy is measured as such when mothers report, “yes,” to a question asking them whether they considered an abortion prior to their child’s birth. In many respects, consideration of an abortion is the most definitive measure of unintended pregnancy, since it could result in termination of the pregnancy altogether; yet, it is the least utilized in the research literature. More commonly, researchers adopt measures of unintendedness by asking mothers whether or not their pregnancies were “mistimed” or “unwanted.” Drawing on the Building Strong Families (BSF) Project, unintended pregnancy is measured by two questions regarding whether the mother wanted a child with the biological father and whether the pregnancy came sooner, at about the right time, or later than she wanted (mistimed pregnancy). Appreciating the potential influence that the biological father may have on the experience of an unintended pregnancy and later parenting and mental health, all analytic models are conducted separately by family structure at the child’s birth (single mothers and mothers cohabiting with the child’s biological father). Results across the FFCW and BSF Project show that both considering an abortion and having an unwanted pregnancy were associated with considerable longstanding risk for maternal mental health and parenting behaviors, especially for mothers who report cohabiting with their child’s biological father at baseline. Within both sources of data, unintended pregnancy was associated with increased parenting stress, less engagement in parenting activities, and increased likelihood of spanking for cohabiting mothers. Notably, these identified associations remained relatively unchanged when utilizing propensity score pair matching techniques. Results from moderation analyses with the FFCWS reveal that maternal education moderates the association between considering an abortion and maternal mental health and parenting behaviors. Results from moderation analyses with the BSF Project reveal that assignment to a BSF Program altered associations between unwanted pregnancy and engagement in parenting and spanking behaviors. There was no negative link between cohabiting mother’s unwanted pregnancy and engagement in parenting for those mothers assigned to the BSF program, whereas there was a negative link in the control group. Similarly, if single mothers were assigned to the BSF treatment and reported that their pregnancy was unwanted, they were less likely to spank their three-year-old children. These findings suggest the possibility that an organized program could alter longitudinal associations between unintended pregnancy and parenting behaviors, even if the program is not targeting experiences of unintended pregnancy specifically.

A promoção da saúde da gestante, que pode ser feita mediante o fornecimento de orientações sobre o processo gestacional, as mudanças físicas e emocionais próprias da gravidez, o trabalho de parto, parto e puerpério, é preconizada como uma das atividades essenciais da assistência pré-natal. Uma cartilha educativa, com orientações fidedignas e significativas na perspectiva das gestantes, representa um subsídio importante para o desenvolvimento das atividades educativas do pré-natal. O objetivo geral desta pesquisa foi elaborar uma cartilha destinada à promoção da saúde da gestante e os específicos foram sistematizar o conteúdo da cartilha, selecionar as ilustrações da cartilha, compor a cartilha, validar o conteúdo da cartilha com a colaboração de peritos e validar a adequação da linguagem e das ilustrações da cartilha com a colaboração de gestantes. As etapas da elaboração da cartilha consistiram na sistematização de seu conteúdo, com base na identificação das demandas dos participantes de um grupo de gestantes mediante abordagem participativa, em momento anterior ao início da presente pesquisa. O conteúdo da cartilha foi elaborado em bases científicas, mediante revisão da literatura. A composição da cartilha, quanto à seqüência das informações, formatação das ilustrações, escolha das cores, diagramação, organização estrutural e formato final, foi realizada mediante assessoria de profissionais de comunicação. A versão preliminar da cartilha foi submetida ao processo de validação, que foi realizado com a colaboração de peritos e gestantes. Um grupo composto por oito peritos, que representavam as categorias de médico obstetra, enfermeiro obstetra, enfermeiro promotor da saúde, educador físico e auxiliar de enfermagem, fizeram a validação das informações, da linguagem, das ilustrações, da apresentação da cartilha e deram sugestões para aperfeiçoar a cartilha. A versão aperfeiçoada da cartilha foi entregue às gestantes em acompanhamento pré-natal em um serviço público de saúde. Elas foram solicitadas a ler a cartilha, indicar palavras, expressões, frases ou ilustrações incompreensíveis e dar sugestões para substituí-las. Este processo foi realizado até a fase em que não foram identificadas dúvidas a respeito do conteúdo da cartilha e isto demandou a inclusão de nove gestantes. Concluída esta etapa, foram realizadas a última edição, a diagramação e a impressão da versão final da cartilha. O processo de construção da cartilha, desenvolvida mediante estratégia participativa, dialógica e coletiva, como preconizada nas práticas de promoção à saúde, foi construtivo e enriquecedor e seu emprego é recomendado para a elaboração de novas cartilhas educativas visando à promoção da saúde / The promotion of health among pregnant women, which can be accomplished by furnishing information about the gestational process, physical and emotional changes specific to pregnancy, labor, delivery and postpartum, is essential to prenatal care. An educational booklet with trustworthy and significant advice could represent an important contribution to prenatal awareness training. The general objective of this study, therefore, was to produce such a booklet: systematizing its content, selecting illustrations, organizing its composition, verifying information with experts, and testing the adequacy of its language and illustrations in collaboration with the target audience. The content systematization was based on the suggestions raised by a group of expectant mothers prior to the beginning of the present project. The content of the booklet was developed through a review of scientific literature. The composition of the booklet, i.e., the formatting of illustrations, color, design, organizational structure and the sequence of information, was accomplished with the help of communications professionals. A preliminary version of the booklet was submitted to a process of validation by both experts and pregnant women. One group of eight professionals, including obstetricians, nurses midwives, a health promotional nurse, a physical education professor and nursing auxiliaries, evaluated the information, language, illustrations, and the general format of the booklet, giving helpful suggestions. The revised version was delivered to nine expectant mothers participating in prenatal care at a public health service center, who were asked to read through the booklet and point out any difficult words, phrases, expressions or illustrations and give suggestions for substitutes. This step continued until no new objections to content could be found, and this final version was reformatted and printed. The process of developing this booklet by means of a collective, participatory dialog, a process widely recommended for health promotion strategies, was both constructive and enriching, and the authors suggest its use in similar enterprises

Kwan Pui-Chun. / Thesis (M.Phil.)--Chinese University of Hong Kong, 2003. / Includes bibliographical references (leaves 140-155). / Abstracts in English and Chinese. / Chapter Chapter 1 --- Introduction / Chapter 1.1 --- Overview --- p.1 / Chapter 1.2 --- Iron homeostasis --- p.5 / Chapter 1.3 --- Natural Resistance Associated Marcophage Protein (Nramp) Family --- p.15 / Chapter 1.4 --- Divalent Metal Transporter 1 (DMT1) --- p.18 / Chapter 1.5 --- Iron Responsive Element (IRE) and Iron Regulatory Protein (IRP) --- p.23 / Chapter 1.6 --- Expression and localization of DMT-1 in human --- p.27 / Chapter 1.7 --- Iron and the developing feus --- p.31 / Chapter 1.8 --- Objectives of the study --- p.36 / Chapter Chapter 2 --- Materials and Method / Chapter 2.1 --- Study population --- p.37 / Chapter 2.2 --- Procedure of surgical termination of pregnancy --- p.38 / Chapter 2.3 --- Tissues collection and preparation --- p.39 / Chapter 2.4 --- Semi-quantitative Reverse Transcription-Polymerase Chain Reaction --- p.44 / Chapter 2.5 --- Immunohistochemistry --- p.49 / Chapter 2.6 --- Statistical analysis --- p.55 / Chapter Chapter 3 --- Results / Chapter 3.1 --- Description of subjects --- p.56 / Chapter 3.2 --- Existence of human DMT-1 isoforms at early pregnancy --- p.58 / Chapter 3.3 --- Relative expression of DMT-1 isoforms to β -actin mRNA expression at different week gestation --- p.67 / Chapter 3.4 --- Cellular localization of DMT-1 isoforms at early pregnancy --- p.91 / Chapter 3.5 --- Relative expression of DMT-1 proteins at early pregnancy --- p.101 / Chapter Chapter 4 --- Discussion / Chapter 4.1 --- Existence of DMT-1 at early pregnancy --- p.116 / Chapter 4.2 --- Expression of DMT-1 isoforms at early pregnancy at gene level --- p.118 / Chapter 4.3 --- Expression of DMT-1 isoforms at early pregnancy at protein level --- p.120 / Chapter 4.4 --- "Comparison expression of DMT-1 between human fetus, human adult and animal studies" --- p.121 / Chapter 4.5 --- Functional importance of DMT-1 at developing fetus at early pregnancy --- p.130 / Chapter 4.6 --- Conclusion --- p.138 / Chapter 4.7 --- Further study --- p.139 / Chapter Chapter 5 --- Reference --- p.140 / Appendix I: Calculation of EM --- p.156

Orientador: Renato Passini Júnior / Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas / Made available in DSpace on 2018-11-27T12:03:46Z (GMT). No. of bitstreams: 1 Dias_TabataReginaZumpano_M.pdf: 2287469 bytes, checksum: 960058f223b535a82e398b29d32d89ff (MD5) Previous issue date: 2012 / Resumo: Introdução: A interrupção voluntária da gravidez, proibida no Brasil, pode levar a situações de abortamento inseguro, que é reconhecidamente um grave problema de saúde pública. É necessário conhecer as circunstâncias envolvidas nesta situação para que seja possível compreender melhor o contexto em que as mulheres recorrem a um abortamento, bem como identificar subgrupos com necessidades especiais de atendimento pelos serviços de saúde. Objetivo: Avaliar alguns fatores sociodemográficos e epidemiológicos associados à interrupção voluntária da gestação. Sujeitos e métodos: Estudo descritivo analítico de corte transversal envolvendo o envio de um questionário estruturado e pré-testado a 15.800 funcionários de uma entidade pública do Estado de São Paulo. Os questionários preenchidos pelos participantes foram enviados de volta em envelope resposta pré-selado. Foram preenchidos 1660 questionários (11% de taxa de resposta), nos quais houve 296 gestações indesejadas e, destas, 165 terminaram em aborto induzido voluntário. Foram realizadas análises bivariada e multivariada por regressão de Poisson para estudar a associação entre a ocorrência de um aborto quando diante de uma gravidez indesejada com algumas características sociodemográficas selecionadas. Resultados: Um quinto dos participantes relatou vivenciar uma gravidez indesejada anterior, e 55,7% deles recorreram ao abortamento naquela ocasião. As maiores proporções de decisão e realização do abortamento foram encontradas entre os participantes do sexo masculino (62,1%), que tinham de 18 a 24 anos por ocasião da gravidez de sua parceira (62,3%), sem filhos (58,9%), não unidos (61,7%) e entre os respondentes com escolaridade superior (70,3%). A maioria das interrupções foi realizada por um médico e pouco mais de 10% dos participantes relataram ter feito uso do misoprostol. A maioria dos abortos (45%) realizou-se entre 1980 e 1989. Dentre os respondentes que referiram aborto realizado por médico, mais da metade (54%) ocorreram na mesma década (entre 1980 e 1989). Dentre aqueles que fizeram uso de misoprostol, 58% o fizeram entre 1990 e 1999. Os participantes relataram que 22,9% das mulheres que abortaram necessitaram de atendimento médico após o aborto e 16,6% foram internadas após recorrerem ao aborto. Conclusão: Na amostra estudada foi possível verificar que um de cada dois dos respondentes por ocasião de uma gravidez indesejada optou pelo abortamento. Chama atenção que as pessoas tiveram acesso a condições menos inseguras para interromper uma gestação indesejada, ainda que num contexto de ilegalidade dessa prática / Abstract: Introduction: Unsafe abortion is a serious public health problem in Brazil and other countries where it is considered a crime. It's necessary to understand the context of these abortions to approach the issue . Objective: To evaluate some sociodemographic and epidemiological factors associated with induced abortion. Method: Cross-sectional study. A self-responded questionnaire was sent to 15.800 employees of a public organization. 1660 questionnaires were completed. There were 296 unintended pregnancies and 165 induced abortions. Bivariate and multivariate Poisson regression analyses were performed to explore the association between the occurrence of abortion when faced an unintended pregnancy with some sociodemographic characteristics. Findings: One fifth of respondents reported an unintended pregnancy and 55.7% of those respondents resorted to abortion. The highest rates of abortion were found among male participants (62.1%) who were between 18 and 24-years-old at the time of pregnancy (62.3%), childless (58.9%), not united (61.7%) and with a college education (70.3%). Most of the respondent's abortions were performed by a doctor, and 17.8% of participants reported misoprostol use. Medical attention was necessary for 22.9% of these women after abortion and 16.6% were hospitalized. Most abortions (45%) took place between 1980 and 1989, and 54% of respondents who had abortions in this decade resorted to a doctor. Those who used misoprostol, 58% did between 1990 and 1999. Conclusion: In this sample we observed that half of respondents opted for abortion during an unintended pregnancy. It is noteworthy that people had access to fewer unsafe conditions for stopping an unintended pregnancy, even in the context of illegal practice / Mestrado / Saúde Materna e Perinatal / Mestra em Ciências da Saúde